UNIVERSITAETSKLINIKUM FREIBURG Patent applications |
Patent application number | Title | Published |
20150335663 | Pharmaceutical Composition Having Synergistic Action Of Direct Catalase Inhibitors And Modulators Of NO Metabolism Or Of Extracellular Superoxide Anion Production Which Lead To Catalase Destruction - The present patent application relates to a pharmaceutical composition, characterized in that it comprises at least one active ingredient which can bring about a singlet oxygen-independent direct catalase inactivation and that the composition further comprises at least one active ingredient that leads to inactivation of catalase as a result of modulation of the nitrogen oxide or superoxide anion metabolism of the cells and subsequent singlet oxygen formation. | 11-26-2015 |
20150296757 | ANIMAL MODEL FOR TYPE 2 DIABETES AND OBESITY - The present invention relates to the use of a genetically modified non-human animal as an animal model for obesity or obesity-related disorders, wherein the amount of Lysine-specific Demethylase 1 (LSD1) in at least one tissue or at least one cell type of said animal is reduced. | 10-22-2015 |
20150093763 | METHOD FOR DIAGNOSIS OF PULMONARY INVOLVEMENT IN SYSTEMIC SCLEROSIS - A method for the diagnosis and/or therapy control of systemic sclerosis is disclosed wherein soluble CD90 is detected in body fluids. By measuring the concentration of soluble CD90 certain forms of diseases can be differentiated by applying the ex vivo method. | 04-02-2015 |
20150061673 | CONTROL UNIT AND METHOD TO MONITOR A DATA ACQUISITION OF MAGNETIC RESONANCE IMAGE DATA - In a control method and control unit to monitor a data acquisition of magnetic resonance image data of an imaging area located in a measurement volume of a magnetic resonance apparatus, an RF excitation pulse is radiated by an RF transmission/reception device of the magnetic resonance apparatus, raw data are acquired after a time after the radiated excitation pulse, by means of the RF transmission/reception device, and store the raw data, the raw data are transmitted to a monitoring unit and (a) through (c) are repeated while switching different gradients for spatial coding by readout of k-space corresponding to the imaging area along trajectories that are predetermined by the switched gradients, up to a termination criterion that is predetermined by the monitoring unit. | 03-05-2015 |
20150017642 | METHOD FOR THE DIAGNOSIS OF MYELOID NEOPLASIAS AND SOLID TUMORS AND DIAGNOSTIC KITS - The present application relates to an ex vivo or in vitro method to determine the presence or absence of a mutation or a variation in the NF-E2 gene in a sample from a patient suffering from a myeloid neoplasm or solid tumor whereby said method comprises: | 01-15-2015 |
20140323427 | URIDINE AND URIDINE ANALOGUES FOR TREATMENT OF SPECIFIC LUNG DISEASES, NAMELY COPD AND PULMONARY FIBROSIS - The present invention relates to the new indications of chronic obstructive pulmonary disease (COPD) and idiophathic lung fibrosis (IPF) for uridine and uridine analogues. | 10-30-2014 |
20140206770 | ANDROGEN RECEPTOR-DEPENDENT GENE EXPRESSION CONTROL - Disclosed is the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one amine oxidase inhibitor suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. | 07-24-2014 |
20140112973 | BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT - The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same. | 04-24-2014 |
20140099648 | MITOCHONDRIAL NUCLEIC ACID AS A MARKER FOR AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES - The present invention relates to a method for increasing the diagnostic likelihood of the presence or absence of, or monitoring the progression or activity of an inflammatory autoimmune disease (AID), comprising detecting mitochondrial NA (e.g. mtDNA) in a sample from an individual suffering from the AID or suspected of suffering from the AID. | 04-10-2014 |
20140099327 | PHARMACEUTICAL COMPOSITION COMPRISING ANTIBODIES AGAINST CATALASE AND SUPEROXIDE DISMUTASE FOR TUMOR THERAPY - The present invention is based on the unexpected finding that, in addition to catalase, SOD is also involved in protecting tumor cells, wherein the inhibition effects of the two protective enzymes support one another in a complementary manner. The invention thus relates to pharmaceutical compositions containing at least two antibodies or the biologically active fragments thereof, wherein the one antibody is directed against the catalase and the other antibody is directed against the superoxide dismutase, as well as their use for treating a tumor disease. | 04-10-2014 |
20130338326 | COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS - The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol | 12-19-2013 |
20130315996 | BIO-FUNCTIONALIZED STIMULUS-RESPONSIVE DISSOLVABLE PEG-HYDROGELS - The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components. | 11-28-2013 |
20130280821 | METHOD FOR DETECTING AN INFECTION BY HEPATITIS B VIRUS - An immunological confirmation method is disclosed for the detection of hepatitis B virus infection wherein the testing of certain samples showing unclear reactivity is repeated once without and once in the presence of recombinantly produced HBcAg particles. If the sample is truly hepatitis B virus core antibody positive, the rHBcAg will trap the anti-HBcAg antibodies and influence the readout accordingly. | 10-24-2013 |
20130171104 | SYNERGISTIC ACTIVITY OF MODULATORS OF THE NO METABOLISM AND OF NADPH OXIDASE IN THE SENSITIZATION OF TUMOR CELLS - What is disclosed is pharmaceutical compositions which contain a pharmaceutically active amount of at least one active substance which increases the available NO concentration in the cell, together with at least one active substance which stimulates the NADPH oxidase. | 07-04-2013 |
20130102884 | NMR measurement of contrast medium concentrations - A method for measuring the cerebral perfusion of a living organism ( | 04-25-2013 |
20130102879 | Method For Correcting Susceptibility-Induced Image Artifacts In MRI After Prospective Motion Correction - A method of magnetic resonance imaging (MRI) is characterized by the following steps: a) forming a susceptibility model ( | 04-25-2013 |
20120074937 | Increasing spoil efficiency - A method for operating a nuclear magnetic resonance imaging device, wherein a continuous sequence of radio-frequency (=RF) pulses are radiated onto a sample, Ψ being the constant phase value for all magnetization vectors, and all magnetization vectors undergo a phase progression F | 03-29-2012 |
20110275929 | Device and method for measuring contrast agent - A tomography device ( | 11-10-2011 |
20110241678 | Method for homogenizing resolution in magnet resonance tomography measurements using non-linear encoding fields - A method for magnetic resonance (=MR) imaging, wherein non-linear gradient fields are applied for the purpose of spatial encoding to acquire images of an object to be imaged and wherein the magnet resonance signal radiated from the object to be imaged is sampled on grids in time, to thereby obtain sampling points, is characterized in that the object to be imaged is mapped completely in regions of stronger gradient fields by increasing the density of the sampling points in the center of k-space, and additional sampling points are specifically acquired in the outer regions of k-space according to a k-space sampling pattern depending on the desired distribution of the resolution in the measurement, wherein the MR measurement is calculated with the additional sampling points. An MR imaging method is thereby provided by means of which homogenized resolution is achieved in the MR measurements using non-linear gradient fields for spatial encoding. | 10-06-2011 |
20110148410 | Method for data acquisition acceleration in magnetic resonance imaging (MRI) using receiver coil arrays and non-linear phase distributions - A method for accelerating data acquisition in MRI with N-dimensional spatial encoding has a first method step in which a transverse magnetization within an imaged object volume is prepared having a non-linear phase distribution. Primary spatial encoding is thereby effected through application of switched magnetic fields. Two or more RF receivers are used to simultaneously record MR signals originating from the imaged object volume, wherein, for each RF receiver, an N-dimensional data matrix is recorded which is undersampled by a factor R | 06-23-2011 |
20110110976 | RIFT VALLEY FEVER VIRUS-LIKE PARTICLES AND THEIR USE FOR IMMUNIZATION AND AS TEST SYSTEM - Disclosed is a method for producing virus-like particles (VLP) that comprises the steps of (a) transfecting a mammalian cell line with several independent vectors, including (1) a vector containing at least a substantial part of the M gene from Rift Valley Fever Virus, (2) a vector containing at least a substantial part of the L gene from Rift Valley Fever Virus, (3) a vector containing at least a substantial part of the N gene from Rift Valley Fever Virus and (4) a vector containing a multicloning site flanked by the non-coding 5′- and 3′-ends of the L-, M- or S-segment of Rift Valley Fever Virus, and (b) culturing the transfected mammalian cell line under suitable conditions and obtaining the VLPs from the supernatant of the transfected cultured cell lines. The so-obtained VLPs can be used for vaccination and in methods for testing the antiviral activity of compounds. | 05-12-2011 |
20100285026 | PHOSPHORYLATION OF HISTONE H3 AT THREONINE 11 - A NOVEL EPIGENETIC MARK FOR TRANSCRIPTIONAL REGULATION - The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells. | 11-11-2010 |
20100259260 | Simultaneous excitation and acquisition of signal from multiple slices in the RARE sequence (multiplex RARE) - A method for RARE magnetic resonance imaging comprising slice selective excitation of two or more slices and of one or more nuclei, followed by refocusing of these slices and application of gradient pulses which cause a diversion of the signal into spin echoes and stimulated echoes, is characterized by application of refocusing slice selective RF pulses, which are placed to fulfill the echo-spacing CPMG condition for each slice and by arrangement of gradient pulses which cause the phase accumulated by spins in each slice between two consecutive refocusing RF pulses corresponding to that slice to be equal, thus fulfilling the CPMG phase accumulation condition. Thereby, the obtainable signal can be increased and stabilized. | 10-14-2010 |
20090302838 | MR method for selective excitation - A magnetic resonance method for using radio frequency pulses for spatially selective and frequency selective or multidimensionally spatially selective excitation of an ensemble of nuclear spins with an initial distribution of magnetization in a main magnetic field aligned along a z-axis, wherein a spin magnetization with a given target distribution of magnetization is generated, and for refocusing the spin magnetization, is characterized in that the radio frequency pulse is used as a sequence of sub-pulses of independent duration, courses of gradients and spatial and/or spectral resolution, comprising one or more large angle RF pulses with tip angles greater than or approximately equal to 15°, which generate a gross distribution of magnetization approximating the target distribution of magnetization or a desired modification of the distribution of magnetization with a mean deviation less than or approximately equal to 15°, wherein the actual effect of the LAPs on the distribution of spin magnetization before the radio frequency pulse is used is calculated by integration of the Bloch equations without small angle approximation, and one or more small angle RF pulses=SAPs with tip angles less than or approximately equal to 15° reducing the difference between the target distribution of magnetization and the gross distribution of magnetization caused by the LAPs. | 12-10-2009 |
20090233317 | REPRESSOR OF SKELETAL MUSCLE DIFFERENTIATION, NUCLEIC ACIDS CODING THEREFOR AND THE USE THEREOF IN DIAGNOSIS AND THERAPY - Polypeptide sequences which play a part in the regulation of skeletal muscle differentiation, and nucleic acids coding therefor, and the use thereof in diagnosis and therapy are disclosed. Possible uses are also indicated for antibodies which are directed against corresponding epitopes of the GRIM1 polypeptide. | 09-17-2009 |