THE UNIVERSITY OF QUEENSLAND Patent applications |
Patent application number | Title | Published |
20160038545 | A METHOD OF ISOLATING CELLS FOR THERAPY AND PROPHYLAXIS - Disclosed are methods for isolating endothelial progenitor cells (EPC). More particularly, the present invention discloses methods for isolating endothelial progenitor cells that exhibit self-renewal and differentiation capacity. The isolated cellular population of the present invention is useful in a wide range of clinical and research setting including inter alia, the in vitro or in vivo generation of endothelial cells and the therapeutic or prophylactic treatment of a range of conditions via the administration of these cells. Also facilitated is the isolation of endothelial progenitor cells for research purposes such as in vitro based screening systems for testing the therapeutic impact and/or toxicity of potential treatment or culture regimes to which these cells may be exposed to. The present invention also discloses methods for isolating mesenchymal stem cells, in particular mesenchymal stem cells of fetal and/or maternal origin. These cells are also useful in a range of in vitro and in vivo therapeutic, prophylactic and research applications. | 02-11-2016 |
20150377880 | CELL-FREE BIOFRAGMENT COMPOSITIONS AND RELATED SYSTEMS, DEVICES, AND METHODS - The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies. | 12-31-2015 |
20150344535 | NEUROTROPHIN-TYROSINE KINASE RECEPTOR SIGNALING - The invention relates to a method of regulating neurotrophin-tyrosine kinase receptor signaling in a cell comprising modulating the interaction between the juxtamembrane region of the intracellular domain of the neurotrophin receptor p75 and Trk. The invention also relates to compositions comprising compounds which modulate the interaction between the juxtamembrane region of the intracellular domain of the neurotrophin receptor p75 and Trk, and use of the compounds and compositions for the treatment of neurotrophin-Trk signaling related diseases and disorders. | 12-03-2015 |
20150293105 | METHODS FOR CLASSIFYING TUMORS AND USES THEREFOR - Disclosed are methods for classifying tumors into EGFR antagonist sensitive or resistant subtypes. Additionally, the present invention discloses methods for stratifying subjects with cancer into treatment subgroups based on whether their tumors fall into one of these subtypes and to methods for treating subjects so stratified. | 10-15-2015 |
20150274562 | Wastewater Refinery - A wastewater refinery comprising one or more electrodialytic cells with mono-, di-, or multi-valent selective membranes interspersed with one or more concentrate compartments to selectively recovery ions from wastewater. The wastewater refinery may harvest ions by utilising techniques including ion selective resins and pervaporation. The refinery finds particular application for recovery of potassium, phosphate and ammonium: | 10-01-2015 |
20150150788 | METHOD AND COMPOSITION FOR DELIVERING A COMPOUND THROUGH A BIOLOGICAL BARRIER - A method for delivering a compound through a biological barrier including applying a force to a plurality of microparticles on a surface of the barrier so that at least some of the microparticles penetrate the biological barrier to facilitate delivery of the compound therethrough. | 06-04-2015 |
20150031600 | DESIGNED BIOSURFACTANTS, THEIR MANUFACTURE, PURIFICATION AND USE - The present invention relates to designed polypeptide biosurfactants that may be prepared by recombinant technology in commercially useful amounts and purified by simple non-chromatographic methods. The designed polypeptide biosurfactants comprise at least one stimuli-responsive amino acid residue or at least one glutamine or asparagine residue and may be useful in modulating the stability of a foam, alone or in combination with an α-helical peptide. The designed polypeptide biosurfactant may be useful in the formation and collapse of foams in foods, beverages, pharmaceuticals, personal care products, cosmetics, cleaning products, mineral recovery, bioremediation, oil recovery and laundry products. The designed biosurfactants may also be useful in recombinant production and purification of peptides, polypeptides and proteins. | 01-29-2015 |
20140329761 | PREVENTION AND TREATMENT OF ACUTE INFLAMMATORY CONDITIONS - The present invention relates generally to methods for the prevention and treatment of acute inflammatory conditions in individuals using an agonist of the complement C3a receptor. | 11-06-2014 |
20140322771 | Lipid Production - The invention relates to methods for producing lipids and in particular methods for producing glycerolipids suitable for use in generating biofuels. The glycerolipids are produced through the modification of a cell so as to increase phosphatidic acid via the inhibition of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. The invention further relates to genetically modified plants and microorganisms in which the production of glycerolipids/oil is increased. | 10-30-2014 |
20140315796 | MODULATORS OF PROTEASE ACTIVATED RECEPTORS - The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities. | 10-23-2014 |
20140302076 | IMMUNOGENIC COMPOSITIONS AND METHODS THEREFOR - The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunise an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere. | 10-09-2014 |
20140259204 | SMALL VIRAL RNA MOLECULES AND USES THEREOF - The present invention discloses small plant virus RNA molecules involved in modulating a plant defence response, particularly non-translated, plant viral microRNA molecules. The present invention also provides methods of their production and uses of these microRNA molecules for reducing a susceptibility of a plant to a pathogen. | 09-11-2014 |
20140202956 | PRE-TREATMENT OF SLUDGE - A method for treating a sludge to be fed to a bioreactor for treating wastewater, or an anaerobic or aerobic sludge digester, the method comprising contacting the sludge with free nitrous acid. | 07-24-2014 |
20140127117 | PREPARATION OF SUSPENSIONS - A method for preparing a suspension of LDH particles comprises the steps of preparing LDH precipitates by coprecipitation to form a mixture of LDH precipitates and solution; separating the LDH precipitates from the solution; washing the LDH precipitates to remove residual ions; mixing the LDH precipitates with water; and subjecting the mixture of LDH particles and water from step (d) to a hydrothermal treatment step by heating to a temperature of from greater than 80° C. to 150° C. for a period of about 1 hour to about 48 hours to form a well dispersed suspension of LDH particles in water. | 05-08-2014 |
20140053294 | Pongamia Genetic Markers and Method of Use - Primers suitable for nucleic acid sequence amplification of | 02-20-2014 |
20140038895 | Single Chain Relaxin Polypeptides - The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor. | 02-06-2014 |
20140038218 | PROTEOLYSIS DETECTION - Disclosed are electrochemical methods, apparatus, systems and kits for the detection or monitoring of proteolysis of proteinaceous matrices such as fibrin clots. The methods, apparatus, systems and kits generally include the use of voltammetric techniques to measure the changes in current that result from diffusion of an electroactive species towards an electrode on proteolysis of a proteinaceous matrix. | 02-06-2014 |
20140030140 | SOLDER ALLOY - A solder alloy may include a Sn—Cu hypereutectic area having Cu in the amount of up to 7.6 weight percent, from 0.006 to 0.5 weight percent of Al, Al | 01-30-2014 |
20140023572 | METHOD OF ORE PROCESSING - A method of selectively leaching a metal such as nickel from an ore or ore processing intermediate comprising the metal and cobalt. The ore or ore processing intermediate is contacted with an acidic leach solution comprising an amount of an oxidising agent sufficient to oxidise a major portion of the cobalt to thereby cause it to be stabilised in the solid phase while a major portion of the metal is dissolved for subsequent recovery. | 01-23-2014 |
20140014506 | ANALYTE TRANSPORT - Apparatus for sensing an analyte, the analyte being bound to at least one magnetic particle to form a labelled analyte, and wherein the apparatus includes a cavity having a sensor therein, wherein in use the cavity contains a fluid and at least one labelled analyte and a magnet system for generating a magnetic field having a field direction substantially orthogonal to at least part of the cavity to orientate the at least one labelled analyte in the cavity and a field gradient along at least part of the cavity to thereby urge the at least one labelled analyte along the cavity towards the sensor. | 01-16-2014 |
20130273584 | SERUM PREPARATION - This invention relates to the use of clotting compositions containing prothrombin activators to produce high quality blood serum samples for pathology and other biological assays, and to containers containing such clotting compositions, and related methods of use. | 10-17-2013 |
20130252838 | TARGET FOR BREAST CANCER THEREAPY AND/OR DIAGNOSIS - The present invention relates to breast cancer and methods for identifying therapeutics and diagnosis. In general, methods for identifying therapeutic agents directed to calcium flow are disclosed. Also provided are methods for diagnosis of breast cancer and/or a predisposition to breast cancer and methods of treatment of breast cancer. The methods include identifying therapeutic agents which modulate a CRAC channel and/or a glycoprotein activator of a CRAC channel. Also provided are diagnostic methods that utilise a CRAC channel and/or a glycoprotein activator of a CRAC channel. | 09-26-2013 |
20130190794 | PATCH APPLYING APPARATUS - Apparatus for applying a patch to a subject, the patch having a number of projections thereon, the apparatus including opposable jaws movable between open and engaging positions, wherein in the open position the jaws can receive at least part of the subject, and in the engaging position the jaws can engage the at least part of the subject and a patch support for supporting a patch, and wherein the patch support is for urging the patch against the at least part of the subject. | 07-25-2013 |
20130184226 | MODULATIONS OF PROTEASE ACTIVATED RECEPTORS - The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity. | 07-18-2013 |
20130174630 | Method and Apparatus for Forming the Profile of Deformable Materials and Deformable Tubular Sections - An apparatus for forming the profile of deformable materials including tubular sections. The apparatus ( | 07-11-2013 |
20130168329 | CONTROL OF BACTERIAL ACTIVITY, SUCH AS IN SEWERS AND WASTEWATER TREATMENT SYSTEMS - A method for controlling the activity of sulfate reducing bacteria or methanogenic archaea (or both) in environments containing such organisms comprising treating the environment with free nitrous acid (HNO | 07-04-2013 |
20130158986 | COMMUNICATIONS ANALYSIS SYSTEM AND PROCESS - A communications analysis process, including: accessing communications data representing communications of processing the communications data to determine similarity data representing similarities between concepts expressed by the one or more persons at different times during said communications; and processing the similarity data to determine one or more metrics of said communications. | 06-20-2013 |
20130137684 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS - The present invention generally relates to compounds that inhibit haematopoietic-prostaglandin D | 05-30-2013 |
20130136762 | MODIFIED SURFACE ANTIGEN - Novel proteins that constitute modified forms of a | 05-30-2013 |
20130097725 | SOYBEAN NODULATION FACTOR RECEPTOR PROTEINS, ENCODING NUCLEIC ACIDS AND USES THEREFOR - The invention provides GmNFR1α, GmNFR1β, GmNFR5α, and GmNFR5β soybean nodulation factor receptor proteins, a receptor complex, and encoding nucleic acids. Also provided are GmNFR1α, GmNFR1β, GmNFR5α, and GmNFR5β promoters, which may be useful for expressing autologous or heterologous sequences in plants, such as soybean. Variant proteins and nucleic acids including RNA splice variants, mis-sense mutants, and non-sense mutants are also described. Also provided are genetically-modified plants and methods of producing genetically-modified plants. Over-expression of soybean nodulation factor receptor proteins by genetically-modified plants may lead to enhanced and/or otherwise facilitated nodulation and/or nitrogen fixation. Genetically-modified plants with down-regulated nodulation factor receptor expression, such as by RNAi or antisense constructs, may exhibit inhibited, diminished, or otherwise reduced nodulation and/or nitrogen fixation. | 04-18-2013 |
20130085262 | NOVEL SURFACE ANTIGEN - The invention provides a novel surface polypeptide from | 04-04-2013 |
20130085188 | PEPTIDE NETWORKS - Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed. | 04-04-2013 |
20130084267 | METHOD FOR STEM CELL DIFFERENTIATION - The present invention relates generally to a method for generating mesenchymal stem cells from pluripotent cells, the method comprising (i) differentiating a population of pluripotent stem cells in the presence of an inhibitor of endogenous activin and TGF-β signalling and (ii) passaging the cells differentiated in step (i) in the presence of a mesenchymal stem cell medium for a time and under conditions sufficient to produce mesenchymal stem cells. The present invention also relates to mesenchymal stem cells produced by the methods of the present invention and uses thereof. | 04-04-2013 |
20130074218 | METHOD FOR OPTIMISING GENE EXPRESSION USING SYNONYMOUS CODON OPTIMISATION - The present invention discloses a method for modulating the quality of a selected phenotype that is displayed by an organism or part thereof and that results from the expression of a polypeptide-encoding polynucleotide by replacing at least one codon of that polynucleotide with a synonymous codon that has a higher or lower preference of usage by the organism or part thereof to produce the selected phenotype than the codon it replaces. The present invention is also directed to the use of a codon-modified polynucleotide so constructed for modulating the quality of a selected phenotype displayed by an organism or part thereof. | 03-21-2013 |
20130059150 | METHOD OF MANUFACTURE FOR HOLLOW FIBRE CERAMIC MEMBRANE - A process for producing a ceramic membrane in the form of a hollow fibre, which process comprises: forming a suspension by mixing inorganic oxide precursor particles with a solution of a polymer binder dissolved in a solvent for the binder; feeding the suspension through a spinneret to form hollow fibres; passing the fibres through an air gap and into a coagulant to solidify the fibres; heating the fibres to remove the polymer binder; and sintering the fibres to render them gas tight, wherein the polymer binder is selected so that it may be removed from the fibres by heating without leaving any residual species within the ceramic that will impair the oxygen permeability of the fibres. | 03-07-2013 |
20130025011 | Ptilotus plant named 'B123' - A new and distinct | 01-24-2013 |
20130005749 | NOVEL FORMULATION AND TREATMENT METHODS - The invention relates to extended release compositions and formulations comprising 6-thioguanine (6-TG), and methods for treating diseases or conditions responsive to 6-TG. | 01-03-2013 |
20130004984 | NEURONAL STIMULATION - A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a β3 adrenergic receptor agonist. | 01-03-2013 |
20120310075 | MEDICAL MEASUREMENT SYSTEM AND METHOD - A method of measuring a range of movement of a joint of a patient including the steps of: capturing an image including at least part of the patient; processing measurement points positioned on the image; determining a measurement axis that connects the measurement points; determining a reference axis; and measuring an angle at an intersection of the measurement axis and the reference axis according to the range of movement of the joint of the patient. The invention also resides in a method of measuring a distance or displacement in an image including the steps of: providing a scale for the image; capturing the image including at least part of a patient and the scale; positioning a marker on the image that defines a distance to be measured; and measuring the distance using the marker and the scale. | 12-06-2012 |
20120294886 | PEPTIDE CONJUGATES FOR SUPPRESSING AN IMMUNE RESPONSE, METHODS OF MAKING AND USES THEREFOR - This application relates to peptide conjugates comprising peptides that suppress or otherwise inhibit an unwanted or undesirable immune response attached to lipid moieties, and methods for suppressing immune responses, including preventing, inhibiting, treating or decreasing unwanted or undesirable immune responses including autoimmune or allergic immune responses using these peptide conjugates. | 11-22-2012 |
20120238507 | ALPHA HELICAL MIMICS, THEIR USES AND METHODS FOR THEIR PRODUCTION - Disclosed are short chain peptides that are constrained to adopt an alpha helicial conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides. Also disclosed is the use of these peptides for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. The peptides find use in mimicking naturally occurring peptides or proteins or in preparing new materials. | 09-20-2012 |
20120178668 | PROTEINACEOUS COMPOUNDS AND USES THEREFOR - The present invention discloses proteinaceous compounds that comprise at least a biologically active portion of a taipan natriuretic peptide (TNP) or a variant or derivative thereof. The invention also relates to the use of these compounds in methods for stimulating vasodilation, natriuresis, diuresis, renin-suppression, bactericidal activity, weight-loss or bone growth in a mammalian host. In specific embodiments, the compounds are useful in the treatment of congestive heart failure. | 07-12-2012 |
20120148574 | Diagnostic Markers for Ankylosing Spondylitis - The present invention discloses methods and agents for diagnosing the presence or risk of development of ankylosing spondylitis (AS) in mammals, which are based on the detection of polymorphisms within any one or more of the ARTS-1 gene, the IL-23R gene, the TNFR1 gene locus, the TRADD gene locus, the IL-1R1 gene locus, the IL-1R2 gene locus, the CD74 gene locus and the chromosome loci 2P15, 2Q31.3 and 4Q13.1. The present invention also features methods for the treatment or prevention of AS based on the diagnostic methods. | 06-14-2012 |
20120123093 | NOVEL SURFACE ANTIGEN - The invention provides a novel surface polypeptide from | 05-17-2012 |
20120065713 | THERMO-ELECTRIC DEVICE - A portable handheld thermo-electric device ( | 03-15-2012 |
20120059173 | DENDRITIC MOLECULES - The invention relates to novel dendritic molecules and methods of making them. The dendritic molecules comprise arms, each of which arms is a polymer. The dendritic molecules can be synthesised by way of a reasonably small number of versatile and reliable step-wise reactions, especially click chemistry reactions. Chemical and structural heterogeneity is possible in the dendritic molecule. The invention also provides for surface and interior functionalisation of the molecule. | 03-08-2012 |
20120046444 | PEPTIDE NETWORKS - Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed. | 02-23-2012 |
20120040367 | CONSTRUCT SYSTEM AND USES THEREFOR - The present invention discloses construct systems and methods for comparing different iso-accepting codons according to their preference for translating RNA transcripts into proteins in cell or tissues of interest or for producing a selected phenotype in an organism of interest or part thereof. The codon preference comparisons thus obtained are particularly useful for modifying the translational efficiency of protein-encoding polynucleotides in cells or tissues of interest or for modulating the quality of a selected phenotype conferred by a phenotype-associated polypeptide upon an organism of interest or part thereof. | 02-16-2012 |
20120032679 | GRADIENT COIL ARRANGEMENT - A gradient coil arrangement for use in a magnetic imaging system, the imaging system being for generating a magnetic imaging field in an imaging region provided in a bore. The coil arrangement includes a first portion having a substantially cylindrical shape for positioning in the bore, a second portion extending outwardly from an end of the first portion, the second portion being for positioning outside the bore and at least one coil for generating a gradient magnetic field in the imaging region, the at least one coil having a first part provided on the first portion and a second part provided on the second portion. | 02-09-2012 |
20120027810 | PATCH PRODUCTION - A method for use in producing a patch having a number of projections thereon. The method includes providing a distribution member and filling material on a mold surface, the mold including a number of cavities extending from the mold surface for defining the patch projections, filling the cavities with filling material, at least in part by urging filling material from the distribution member into the cavities, causing the filling material to solidify and separating the solidified filling material and the mold to thereby form the patch. | 02-02-2012 |
20120004749 | MULTI-PARAMETRIC ANALYSIS OF SNORE SOUNDS FOR THE COMMUNITY SCREENING OF SLEEP APNEA WITH NON-GAUSSIANITY INDEX - An apparatus for diagnosing sleep disorders such as OASHS from snore sounds includes a segmentation module ( | 01-05-2012 |
20110318610 | PRODUCTION OF HYDROGEN PEROXIDE - A process for producing hydrogen peroxide comprising the steps of providing a bioelectrochemical system having an anode and a cathode, feeding a feed solution containing organic or inorganic (or both) material to the anode, oxidising the organic or inorganic material at the anode, providing an aqueous stream to the cathode of the bioelectrochemical system, reducing oxygen to hydrogen peroxide at the cathode, and recovering a hydrogen peroxide containing stream from the cathode. | 12-29-2011 |
20110315561 | TREATMENT OF SOLUTIONS OR WASTEWATER - A method for treating a wastewater stream containing organic material or inorganic material comprising passing the wastewater stream to an anode or a cathode of a bioelectrochemical system to thereby alter the pH of the wastewater stream to: a) reduce the pH of the stream passed to the anode to minimise or suppress precipitation of dissolved cations; or b) increase the pH of the stream passed to the cathode to produce an alkaline stream; or c) reduce the pH of the stream passed to the anode to produce an acid containing stream. In one embodiment, a caustic soda solution is produced at the cathode and recovered for storage and subsequent use. | 12-29-2011 |
20110315560 | PROCESS FOR THE PRODUCTION OF CHEMICALS - A process for producing one or more chemical compounds comprising the steps of providing a bioelectrochemical system having an anode and a cathode separated by a membrane, the anode and the cathode being electrically connected to each other, causing oxidation to occur at the anode and causing reduction to occur at the cathode to thereby produce reducing equivalents at the cathode, providing the reducing equivalents to a culture of microorganisms, and providing carbon dioxide to the culture of microorganisms, whereby the microorganisms produce the one or more chemical compounds, and recovering the one or chemical compounds. | 12-29-2011 |
20110301487 | METHOD AND APPARATUS FOR DETERMINING SLEEP STATES - An apparatus is provided for detecting Macro Sleep Architecture states of a subject such as WAKE, NREM and REM sleep from a subject's EEG. The apparatus includes an EEG digital signal assembly of modules arranged to convert analogue EEG signals into digital EEG signals. A bispectrum assembly is responsive to the EEG digital signal assembly and converts the digital EEG signals into signals representing corresponding bispectrum values. A bispectrum time series assembly, in electrical communication with an output side of the bispectrum assembly, generates at least one bispectrum time series for a predetermined frequency. A macro-sleep architecture (MSA) assembly is responsive to the bispectrum time series assembly and is arranged to produce classification signals indicating classification of segments of the EEG signals into macro-sleep states of the subject. | 12-08-2011 |
20110287039 | EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE - The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces. | 11-24-2011 |
20110281817 | PRODUCTION OF HYALURONIC ACID - Methods for producing hyaluronic acid are described, including altering the activity in | 11-17-2011 |
20110274713 | ANTIGEN-PRESENTING SCAFFOLDS - The invention relates to compounds having formula (I): Scaffold-[L-(Antigen) | 11-10-2011 |
20110263687 | RNA MOLECULES AND USES THEREOF - The present invention relates to substantially single-stranded isolated RNA molecules comprising 18 to 19 contiguous nucleotides that corresponds to a non-protein-coding genomic DNA sequence located between −60 and +120 nucleotides from a transcription start site in a mammalian genome. Specifically, the isolated RNA molecules have a high GC content (>60%), are nuclear specific, and may be associated with aberrant gene regulation and/or transcription in various mammalian diseases and conditions. The isolated RNA molecules, modified RNA molecules and fragments thereof may be particularly useful for the diagnosis, prognosis and treatment of diseases such as Crohn's disease, Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, myocardial infarction, diabetes, congenital developmental disorders, coronary heart disease and cancer such as breast cancer, lymphoma, leukemia, aggressive metastatic brain cancers, colorectal cancer, gastric cancer, ovarian cancer and pituitary tumors. | 10-27-2011 |
20110252507 | TRANSGENIC PLANTS USED AS A BIOREACTOR SYSTEM - The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins, pharmaceuticals and nutraceuticals. More particularly, the present invention contemplates the use of grasses, and even more particularly C4 grasses, such as sugarcane, for the production of a range of compounds such as, for example, polyhydroxyalkanoates, pHBA, vanillin, indigo, adipic acid, 2-phenylethanol, 1,3-propanediol, sorbitol, fructan polymers and lactic acid as well as other products including, inter alia, other plastics, silks, carbohydrates, therapeutic and nutraceutic proteins and antibodies. The present invention further extends to transgenic plants and, in particular, transgenic C4 grass plants, capable of producing the compounds noted above and other products, and to methods for generating such plants. The ability to utilize the high growth rate and efficient carbon fixation of C4 grasses is advantageous, in that it obviates the significant growth penalties observed in other plants, and results in high yields of desired product without necessarily causing concomitant deleterious effects on individual plants. In addition, the C4 grass, sugarcane, is particularly advantageous, as in addition to the features common to all C4 grasses, this plant accumulates sucrose. This sucrose store provides a ready supply of carbon based compounds and energy which may further obviate any deleterious effects on the growth of the plant associated with the production of the product. The present invention provides, therefore, a bioreactor system comprising a genetically modified plant designed to produce particular metabolic or biosynthetic products of interest. | 10-13-2011 |
20110244564 | CYSTINE KNOT MOLECULES - The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in defined orientations with respect to each other. The cyclic proteins of the present invention provide a molecular framework for the introduction of particular amino acids or heterologous amino acid sequences to facilitate the presentation of biological activities associated with these heterologous amino acid sequences. The molecular framework of the present invention may be naturally cyclic or may be a cyclized derivative of a linear molecular or may be a linear derivative of a cyclized molecule. The present invention contemplates the use of the molecular framework with or without particular ammo acids inserted or substituted thereon for the treatment of or prophylaxis of disease conditions in animals, mammals (including humans) and plants. | 10-06-2011 |
20110223542 | PATCH PRODUCTION - A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen. | 09-15-2011 |
20110217665 | SURFACE STRUCTURE MODIFICATION - A method of forming an optical fibre tip, the method including, roughening at least part of an end portion of the optical fibre; and, etching the roughed end portion to thereby form an optical fibre tip. | 09-08-2011 |
20110210735 | MRI APPARATUS AND METHOD WITH MOVING FIELD COMPONENT - Apparatus for use in a magnetic resonance imaging system, the imaging system generating a magnetic imaging field in an imaging region ( | 09-01-2011 |
20110182670 | SOIL REMEDIATION PROCESS - The invention provides a process for remediation of sites contaminated with metals such as former industrial sites and mines. In particular the invention provides a process for site remediation comprising the steps of: (a) adding metal-binding particles to a site containing one or more metal contaminants such that at least some of the one or metal contaminants are sequestered by the particles, and (b) populating the site with plants. The use of the particles of the present invention in association with plants, and microbiota associated with the plant roots can achieve sustainable phytostabilisation of contaminated sites. | 07-28-2011 |
20110160069 | ANALYTE DETECTION USING A NEEDLE PROJECTION PATCH - Apparatus for use in detecting analytes in a subject, wherein the apparatus includes a number of projections provided on a patch, such that applying the patch to the subject causes at least some of the projections to be inserted into the subject and target one or more analytes and a reagent for detecting the presence or absence of analytes. | 06-30-2011 |
20110145939 | MODIFIED ARTHROPOD AND METHOD OF USE - A modified arthropod, an arthropod-modifying bacterium, and use thereof as an agent for control of diseases transmitted by arthropods, particularly mosquitoes, is provided. More specifically, an isolated arthropod-adapted | 06-16-2011 |
20110129485 | Modified Galectin-2 and Uses Thereof - An isolated modified galectin-2 protein comprising a mutation and/or modification which improves one or more properties of said isolated modified galectin-2 are provided. More particularly, the mutation of galectin-2 is substitution of cysteine 57, preferably with a methionine residue. Modification of an isolated galectin-2 includes a modification of cysteine 75. Modification includes chemical modification by PEGylation or alkylation. Also provided are isolated nucleic acid, genetic constructs comprising said isolated nucleic acids, antibodies, compositions and methods of modulating an immune response that may be useful in therapeutic and/or prophylactic treatment of disease, disorders or considers which involve an immune response is mediated by one or more cytokines or other soluble immunomodulators and/or the immune response is mediated by one or more cells of the immune system. | 06-02-2011 |
20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
20110060072 | POLYMER COMPOSITES HAVING PARTICLES WITH MIXED ORGANIC MODIFICATIONS - The present invention relates to polymer composites prepared from a host polymer and particles. Specifically, this invention is concerned with the organic modification of the particles. More specifically, the particles are organically modified with at least two organic modifiers that are different and have specific chemical and physical properties. | 03-10-2011 |
20110053851 | HAEMOSTASIS-MODULATING COMPOSITIONS AND USES THEREFOR - This invention discloses the use of snake venom FV polypeptides in methods and compositions for preventing or reducing blood loss or bleeding during bleeding episodes. | 03-03-2011 |
20110020374 | EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE - The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces. | 01-27-2011 |
20110008293 | DEVICE AND METHOD FOR PREPARING MICROPARTICLES - The invention provides a method for preparing microparticles comprising mixing a first cross-linkable reagent in aerosol form with a second cross-linking reagent in aerosol form to thereby to form microparticles. | 01-13-2011 |
20100331537 | NOVEL SURFACE ANTIGEN - The invention provides a novel surface polypeptide from | 12-30-2010 |
20100330116 | LIVE ATTENUATED SALMONELLA FOR USE AS VACCINE - The present invention relates to live attenuated | 12-30-2010 |
20100304226 | MICROBIAL FUEL CELL - A microbial fuel cell having a pathway for passage of effluent from the anode to the cathode is provided, in addition to an ion exchange membrane between the chambers. Effluent may also pass from cathode to anode forming a continuous loop. Oxidation of effluent at the anode creates ammonium ions and produces electrons for an external circuit. The ammonium ions undergo nitrification at the cathode. Alternatively a nitrification reactor may be provided in the effluent pathway. Electrons are received by the cathode from the external circuit to reduce nitrate ions created by the nitrification process. | 12-02-2010 |
20100298528 | Cystine knot molecules - The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in defined orientations with respect to each other. The cyclic proteins of the present invention provide a molecular framework for the introduction of particular amino acids or heterologous amino acid sequences to facilitate the presentation of biological activities associated with these heterologous amino acid sequences. The molecular framework of the present invention may be naturally cyclic or may be a cyclized derivative of a linear molecular or may be a linear derivative of a cyclized molecule. The present invention contemplates the use of the molecular framework with or without particular amino acids inserted or substituted thereon for the treatment of or prophylaxis of disease conditions in animals, mammals (including humans) and plants. | 11-25-2010 |
20100276955 | TREATMENT OF RAILWAY WHEELS - A method of treating a steel railway wheels to form a required distribution of compressive residual stress in the rim. In general terms the wheel heated and then quenched from the plate towards the rim. The wheel is first heated to form austenite throughout the plate and rim portions. The wheel is then cooled to form bainite/martensite in the plate portion. The wheel is cooled to form bainite/martensite in an inner portion of the rim. The wheel is cooled to form bainite/martensite in an outer portion of the rim. | 11-04-2010 |
20100273983 | METHOD OF PURIFYING PEPTIDES BY SELECTIVE PRECIPITATION - A method is provided for purifying peptides by selective precipitation of contaminating proteins, such as host cell proteins and cleaved fusion partners. Also provided is a method of cleaving fusion proteins in cell lysates. | 10-28-2010 |
20100267846 | MOLECULAR DELIVERY VEHICLE - An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol is disclosed. Also disclosed is a method of making an isolated caveolin containing vesicle, an isolated caveolin containing vesicle comprising a recombinant caveolin protein, an isolated caveolin containing delivery vesicle, a method of making an isolated caveolin containing delivery vesicle and a method of treatment of a disease or condition by delivery of a molecule using the isolated caveolin containing delivery vesicle. | 10-21-2010 |
20100233286 | PREPARATIONS OF SUSPENSIONS - A method for preparing a suspension of LDH particles comprises the steps of preparing LDH precipitates by coprecipitation to form a mixture of LDH precipitates and solution; separating the LDH precipitates from the solution; washing the LDH precipitates to remove residual ions; mixing the LDH precipitates with water; and subjecting the mixture of LDH particles and water from step (d) to a hydrothermal treatment step by heating to a temperature of from greater than 80° C. to 150° C. for a period of about 1 hour to about 144 hours to form a well dispersed suspension of LDH particles in water. | 09-16-2010 |
20100215684 | STREPTOCOCCUS M PROTEIN, IMMUNOGENIC FRAGMENTS, NUCLEIC ACIDS AND METHODS OF USE - Isolated M proteins, or M-like proteins, of | 08-26-2010 |
20100207018 | METHOD AND APPARATUS FOR THE CHARACTERISATION OF GEOLOGICAL MATERIALS - The invention provides a method and apparatus for the identification of a constituent of or within a rock. The method included: applying low level electromagnetic energy to the rock thereby inducing a thermal response from the constituent; imaging the thermal response from the constituent to obtain thermal image within a plurality of distinctive bands of IR spectra; interpreting the thermal images to identify the constituent. The apparatus includes: a low level electromagnetic energy generator/applicator for inducing a thermal response from the constituent; an infra-red imaging device for imaging the thermal responses induced within a plurality of distinctive bands of IR spectra; and a computing device for interpreting the thermal images produced by the imaging device to identify the constituent within the rock. | 08-19-2010 |
20100204825 | ROCK ANALYSIS APPARATUS AND METHOD - The invention provides a method and apparatus for the analysis of rocks and rock fragments. A method for the analysis of a rock fragment including: feeding the rock fragment to a microwave irradiation zone of microwave energy generated by a microwave source; gauging energy absorbed by the rock fragment; and correlating rate of change of the gauged energy absorbed by the rock fragment with compositional characteristics of the rock fragment. The rock fragment analysis assembly including: a microwave energy source that generates a microwave irradiation zone; a rock fragment feed that facilitates the feeding of rock fragments into the microwave irradiation zone; at least one primary sensor located on a microwave energy source side of the microwave irradiation zone for gauging microwave energy absorbed by the rock fragments in the microwave irradiation zone; and a processing unit for correlating rate of change of the gauged energy | 08-12-2010 |
20100203051 | DIAGNOSTIC MARKERS FOR ANKYLOSING SPONDYLITIS AND USES THEREOF - Disclosed are methods and agents for detecting the presence or diagnosing the risk of ankylosing spondylitis (AS) in mammals. These methods are based on the detection of polymorphisms within any one or more of the ARTS-1 gene, the IL-23R gene, the TNFR1 gene locus, the TRADD gene locus and the chromosome loci 2P15 and 21Q22. The present invention also features methods for the treatment or prevention of AS based on the diagnosis. | 08-12-2010 |
20100183471 | METAL INJECTION MOULDING METHOD - A method for forming an article by metal injection moudling of aluminium or an aluminium alloy. The method comprises the steps of forming a mixture containing an aluminium powder or an aluminum alloy powder or both and optionally ceramic particles, a binder, and a sintering aid comprising a low melting point metal. The mixture is injection moulded and the binder is removed to form a green body. The green body is sintered. The sintering is conducted in an atmosphere containing nitrogen and in the presence of an oxygen getter. | 07-22-2010 |
20100182009 | COIL DECOUPLING - A Magnetic Resonance Imaging (MRI) phased array head coil ( | 07-22-2010 |
20100170315 | Assembly and Method for Press Forming a Deformable Material - An assembly for press forming a deformable material including: a first die array including a plurality of dies, the first die array defining a first die profile; a second die array that is complementary with the first die array and including a plurality of dies, the second die array defining a second die profile that is complementary with the first die profile; and a drive for driving at least one of the first die array and the second die array; wherein in use the plurality of dies of the first die array and the plurality of dies of the second die array sequentially engage the deformable material along a processing length to deform the deformable material to a predetermined profile. | 07-08-2010 |
20100152420 | PEPTIDE NETWORKS - Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed. | 06-17-2010 |
20100151569 | METHOD OF PRODUCING A POPULATION OF CELLS - A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising neutrophil progenitor cells; and (b) culturing the population of cells in an animal cell culture medium comprising (i) one or more early acting cytokines and (ii) one or more cytokines that differentiate said progenitor cells into a neutrophil specific lineage, under conditions of low oxidative stress, the culture medium being agitated when the cells are at a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and the progeny thereof under static conditions, to produce a population of post-mitotic cells of the neutrophil lineage. The resulting population of cells can be used to increase the number of neutrophils in a patient. | 06-17-2010 |
20100151000 | COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES - This invention discloses methods and compositions for modulating immune responses, which involve particulate delivery of agents to immune cells, wherein the agents comprise an inhibitor of the NF-κB signaling pathway and an antigen that corresponds to a target antigen. The methods and compositions of the present invention are particularly useful in the treatment or prophylaxis of an undesirable immune response associated with the target antigen, including autoimmune diseases, allergies and transplantation associated diseases. | 06-17-2010 |
20100120670 | CYCLISED ALPHA-CONOTOXIN PEPTIDES - This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration. | 05-13-2010 |
20100068762 | NOVEL NUCLEIC ACID MOLECULES - The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as acyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation. | 03-18-2010 |
20100065734 | PARTICLE SORTING APPARATUS AND METHOD - A particle sorting apparatus for sorting particles following a free flight trajectory including: a detector for detecting a characteristic of the particles before or after they enter the free flight trajectory; an ionization source that emits a stream of ions for selectively applying charge to particles following the free flight trajectory; a static electric field for deflecting particles that have been charged by the ionization source; and means for deflecting the stream of ions emitted from the ionization source between a first orientation in which the stream of ions does not intersect the free flight trajectory and a second orientation in which the stream of ions does intersect the free flight trajectory depending on whether a particle following the free flight trajectory is detected as having the characteristic or not. | 03-18-2010 |
20100042383 | Method of Predicting Breakage Properties of a Particulate Material when Subjected to Impact - A method of predicting breakage properties of a particulate material when subjected to impact, the method including: calculating a breakage index for the particulate material using the following equation: Breakage Index=M{I−exp[−f | 02-18-2010 |
20100030096 | METHOD OF ACQUIRING A PHYSIOLOGICAL RESPONSE - A method for acquiring a physiological response from a test subject, particularly an auditory brainstem response, by presenting a plurality of stimuli, such as a Maximum Length Sequence, detecting electrophysiological signals in response to the stimuli, generating a recover signal based on the stimuli and determining the physiological response from the electrophysiological signals and the recovery signal. | 02-04-2010 |
20100028375 | VLP BASED VACCINE DELIVERY SYSTEM - An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus. | 02-04-2010 |
20100015321 | SCAFFOLD TREATMENT - DEVICE AND METHOD - An apparatus for treating porous polymeric scaffolds including an enclosure; a support for at least one porous polymeric scaffold, and at least one application outlets within the enclosure for applying a liquid agent onto the top surface of the at least one porous polymeric scaffold; each porous polymeric scaffold being supported on a drained platform above a liquid catchment area within the enclosure and having at least one application outlet directed at its top surface | 01-21-2010 |
20090327259 | AUTOMATIC CONCEPT CLUSTERING - A method of identifying thematic groups of nodes by analysis of a corpus of documents. The method uses a distance metric based on connectedness of nodes, which is derived from a co-occurrence measure. The invention is also embodied as a computer-implemented visualization tool that generates a display of nodes and thematic groupings. The invention is useful for ‘data mining’ a large corpus of documents, particularly textual documents, to extract relevant information. | 12-31-2009 |
20090326017 | PAIN-RELIEVING COMPOSITIONS AND USES THEREFOR - This invention discloses compositions and methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention discloses the use of sub-normovasodilatory doses of nitric oxide donors in the therapeutic management of vertebrate animals including humans, for the prevention or alleviation of pain, especially neuropathic pain. According to some embodiments of the present invention, nitric oxide donors are administered by any suitable route so as to provide concentrations of NO that are about ½ to 10 | 12-31-2009 |
20090275498 | NOVEL PEPTIDES - The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them. | 11-05-2009 |
20090252761 | Papilloma virus vaccine - A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papilloma virus L1 protein or a combination of papilloma virus L1 protein and papilloma virus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs. | 10-08-2009 |
20090220537 | VACCINE DELIVERY SYSTEM - An isolated protein comprising a hepatitis B surface antigen (HBsAg) amino acid sequence, and encoding nucleic acid, are provided wherein one or more immunogenic T cell epitopes of the HBsAg are respectively substituted with one of more immunogenic T cell epitopes of a protein other than HBsAg. Typically, the T cell epitopes are of a pathogen or tumour protein. The isolated protein may have endogenous HBsAg epitopes substituted with multiple copies of the same epitope or with different HBsAg epitopes. B cell epitopes may also be present. Also provided are expression constructs, VLPs, compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of diseases including human papillomavirus, respiratory syncytial virus, human immunodeficiency virus (HIV), cytomegalovirus (CMV), Epstein Barr virus (EBV), rotavirus, hepatitis B virus, parainfluenza virus, hepatitis C virus, | 09-03-2009 |
20090203760 | CYCLIC AGONISTS AND ANTAGONISTS OF C5a RECEPTORS AND G PROTEIN-COUPLED RECEPTORS - The present invention relates to novel cyclic or constrained acyclic compounds which modulate the activity of G protein-coupled receptors and are useful in the treatment of conditions mediated by G protein-coupled receptors, for example, inflammatory conditions. | 08-13-2009 |
20090199625 | Apparatus for Determining Breakage Properties of Particulate Material - An apparatus for determining the breakage properties of a particulate material, the apparatus including: a support; a rotor mounted relative to the support and including at least one guide channel through which a particle of the particulate material is guided in use, the guide channel having an inlet and an outlet; a drive associated with the rotor; a feed channel for feeding particles of the particulate material to the inlet of the guide channel; a stator associated with the rotor and including an impact surface that is radially spaced from a circumferential edge of the rotor; and a collector for collecting pieces of the particulate material following impact; wherein the apparatus is provided with a control system for accurate control and adjustment of impact velocity of the particulate material with the impact surface. | 08-13-2009 |
20090149769 | PLAID MOTION RIVALRY FOR DIAGNOSIS OF PSYCHIATRIC DISORDERS - A method and apparatus for diagnosing a psychiatric disorder or, a predisposition thereto, in a test subject is provided, wherein perceptual rivalry is measured in the test subject during exposure to a moving plaid stimulus. The method may include the step of determining an interhemispheric switch rate of the test subject, and comparing the switch rate with a corresponding reference switch rate to diagnose presence or absence of the psychiatric disorder. Particular psychiatric disorder s include mood disorders and schizophrenia. Also provided is use of the diagnostic method in genetic linkage studies for the identification of the molecular defect(s) underlying a psychiatric disorder, and for the identification of compounds which may alleviate the disorder. | 06-11-2009 |
20090143417 | METHODS OF TREATING PAIN - The present invention is directed to methods and compositions for inducing, promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management of vertebrate animals including humans, for the prevention or alleviation of pain, particularly moderate to severe pain. In particular, the nitric oxide donor is a slow-release nitric oxide donor or is formulated to provide a sustained release of a low dose of nitric oxide. | 06-04-2009 |
20090136546 | IMMUNOMODULATING COMPOSITIONS AND USES THEREFOR - The present invention discloses the use of an inhibitor of IL-10 function and an immune stimulator that stimulates the priming of an immune response to a target antigen, in methods and compositions for stimulating and prolonging host immune responses to the target antigen. The methods and compositions of the present invention are particularly useful in the treatment or prophylaxis of a range of conditions including pathogenic infections and cancers. | 05-28-2009 |
20090130070 | METHOD OF TREATMENT - The present invention discloses the use of fetuin and fetuin producing agents in methods and compositions for treating burn injuries in animals. | 05-21-2009 |
20090123325 | Magnesium Alloys For Hydrogen Storage - A method of producing a hydrogen storage material including the steps of: forming a magnesium-nickel melt having up to 50 wt % nickel; adding up to 2 wt % of a refining element to the melt under a non-oxidising atmosphere, the refining element having an atomic radius within the range of 1-1.65 times the atomic radius of magnesium, such as at least one element selected from the group consisting of Zr, Na, K, Ba, Ca, Sr, La, Y, Yb, Rb and Cs; and solidifying the melt to produce the hydrogen storage material. | 05-14-2009 |
20090076742 | ESTIMATION OF WHEEL RAIL INTERACTION FORCES - A method of estimating contact forces between the wheels of a railway wagon and a rail track, for use in determining information such as the likelihood of derailment. Accelerations of the body of the wagon are measured using motion sensors located at suitable points on the body. Forces on the side frames of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. Forces on the wheels of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. The contact forces between the wheels and the rails are then calculated based on the forces calculated for the side frames and the wheels. The calculations are carried out using an inverse model of the wagon system. Equipment which implements the method is also described. | 03-19-2009 |
20090068229 | MODIFIED SURFACE ANTIGEN - Novel proteins that constitute modified forms of a | 03-12-2009 |
20090068216 | MODIFIED SURFACE ANTIGEN - Novel proteins that constitute modified forms of a | 03-12-2009 |
20090004264 | METHODS FOR TREATING AND AMELIORATING THE SYMPTONS OF INFLAMMATORY BOWEL DISEASES - This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed. | 01-01-2009 |
20080274156 | Composition forstimulating bone growth and differentiation and method for isolating same - This invention relates to isolated heparan sulphate and use thereof to stimulate bone cell growth and differentiation. The invention also relates to use of heparan sulphate with implants, prosthesis and bioscaffolds to repair and regenerate bone. Such use may be for repair of damaged tissue including bone tissue, for example damage resulting from injury or defect. | 11-06-2008 |
20080269633 | Sonification of Level of Consciousness of a Patient - The level of consciousness of a patient (i.e. the hypnotic state and/or the level of anaesthesia) is represented aurally. A measure of the patient's level of consciousness, such as the BIS index value, is obtained, and an audio signal is synthesized from that measure, and then output through a speaker. Both the volume and pitch of the audio signal may vary according to the BIS value being represented, so that a clinician can obtain an indication of the level of consciousness of the patient simply by listening to the sonification of the BIS value. The audio signal may comprise first and second audio components, with the first component representing the previous measure and the second component representing the current measure. The amplitude or pitch of the audio signal may be modulated to represent analgesia or paralysis of the patient. | 10-30-2008 |
20080254023 | Treating Gliosis, Glial Scarring, Inflammation or Inhibition of Axonal Growth in the Nervous System by Modulating Eph Receptor - The present invention relates to a method of treating disorders of the nervous system and more particularly disorders associated with a gliotic response and/or an inflammatory response within the central nervous system and to therapeutic agents useful for same. More particularly, the present invention involves a method of preventing or reducing the amount of Eph receptor-mediated gliosis and/or glial scarring and/or inflammation and/or Eph receptor-mediated inhibition of axonal growth which occurs during and/or after disease or injury to the nervous system. The present invention also facilitates the identification of therapeutic agents which modulate Eph receptor-mediated signaling. The method and therapeutic agents of the present invention are useful for treating a range of nervous system diseases, conditions and injuries including, inter alia, paralysis induced by physiological-, pathological- or trauma-induced injury to the brain or spinal cord. | 10-16-2008 |
20080248067 | Immunomodulating Compositions and Uses Therefor - The present invention discloses the use of an inhibitor of IL-10 function and an immune stimulator that stimulates the priming of an immune response to a target antigen, in methods and compositions for stimulating and prolonging host immune responses to the target antigen. The methods and compositions of the present invention are particularly useful in the treatment or prophylaxis of a range of conditions including pathogenic infections and cancers. | 10-09-2008 |
20080242598 | Alpha Helical Mimics, Their Uses and Methods For Their Production - This invention discloses short chain peptides that have been constrained to adopt an alpha helical conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides and for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. More particularly the invention discloses alpha helical cyclic pentapeptides and their use as alpha helical scaffolds or macrocyclic alpha helical modules, either alone, or within longer chain peptides or attached to other macrocyclic peptides or attached to non-peptidic structures, for the purpose of mimicking naturally occurring peptides or proteins, and as agonists or antagonists of the biological activity of naturally-occurring peptides or proteins or for the preparation of new materials. | 10-02-2008 |
20080229455 | Altered metabolism - The present invention relates to methods for increasing the yield of a compound produced by an organism. More particularly, the present invention relates to methods for increasing the total or soluble carbohydrate content or sweetness or increasing the content of an endogenous carbohydrate of a plant tissue by producing a sugar-metabolizing enzyme that catalyzes the conversion of an endogenous sugar (one that is normally produced in the plant) to an alien sugar (one that is not normally produced in the plant at the same developmental stage). The invention also relates to plants and plant parts that produce a sugar-metabolizing enzyme to yield an alien sugar, with the consequence of higher total fermentable carbohydrate content, and to fermentable carbohydrates and other products derived therefrom. | 09-18-2008 |