THE REGENTS OF THE UNIVERSITY OF MICHIGAN Patent applications |
Patent application number | Title | Published |
20160141431 | INTEGRATED SOLAR COLLECTORS USING EPITAXIAL LIFT OFF AND COLD WELD BONDED SEMICONDUCTOR SOLAR CELLS - There is disclosed ultrahigh-efficiency single- and multi-junction thin-film solar cells. This disclosure is also directed to a substrate-damage-free epitaxial lift-off (“ELO”) process that employs adhesive-free, reliable and lightweight cold-weld bonding to a substrate, such as bonding to plastic or metal foils shaped into compound parabolic metal foil concentrators. By combining low-cost solar cell production and ultrahigh-efficiency of solar intensity-concentrated thin-film solar cells on foil substrates shaped into an integrated collector, as described herein, both lower cost of the module as well as significant cost reductions in the infrastructure is achieved. | 05-19-2016 |
20160140316 | SYSTEMS AND METHODS FOR AUTOMATICALLY EVALUATING MEDICAL PATIENT SYMPTOMS AND PROVIDING TAILORED PRESCRIPTIONS - The present disclosure is generally related to automatically evaluating medical patient symptoms and, more specifically, to systems and methods for providing tailored prescriptions, multi-dimensional patient matching and symptom monitoring. In particular, a medical patient completes a questionnaire, responses to the questionnaire are correlated with information obtained from a medical knowledge resource and an integrated symptoms summary is generated based on the responses to the questionnaire and the information obtained from the medical knowledge resource. A tailored prescription is provided to the patient based on the integrated symptoms summary and physician consultation (if applicable), patients are compared to other patients according to questionnaire responses so that they can connect with each other if they chose, and patients are able to monitor symptoms over time so that they can gain insight into whether treatments are working. | 05-19-2016 |
20160129400 | SUPERHYDROPHILIC AND OLEOPHOBIC POROUS MATERIALS AND METHODS FOR MAKING AND USING THE SAME - The present disclosure provides a porous material having a surface that is concurrently both superhydrophilic (having a first apparent advancing dynamic contact angle of less than or equal to about 5° for water) and oleophobic (having a second apparent advancing dynamic contact angle of greater than or equal to about 90°) or superoleophobic (a second apparent advancing dynamic contact angle of greater than or equal to about 150° for oil). Such materials can be used in a separator device to separate a liquid-liquid mixture of immiscible components (e.g., oil and water) or miscible components (e.g., alcohols). Separation apparatus incorporating such materials and methods of making and using these materials are also provided. | 05-12-2016 |
20160108732 | SWITCH GAIN SCHEDULED EXPLICIT MODEL PREDICTIVE CONTROL OF DIESEL ENGINES - A method for controlling an internal combustion engine using a controller that controls an air flow path by adjusting at least one of a variable geometry turbine (VGT) and an exhaust gas recirculation (EGR) flow rate during engine operation. The method determines inputs, such as engine speed and fuel rate from the sensor data, and employs a switch based gain-scheduled explicit model predictive controller (MPC) responsive to the inputs to determine the air flow path. | 04-21-2016 |
20160060271 | DEUTERATED AMLEXANOX - Provided herein is technology relating to deuterated amiexanox and particularly, but not exclusively, to compositions comprising deuterated amiexanox, methods of producing deuterated amiexanox, and uses of deuterated amiexanox. Provided herein are deuteratecl amiexanox compounds for the treatment of obesity, insulin resistance, diabetes, and steatosis. In addition, the deuterated compounds are anti-inflammatory antiallergic immunomodulators. e.g., for the treatment of diseases associated with inflammation. The deuterium kinetic isotope effect associated with placing deuterium at the site of metabolic derivatization slows metabolic derivatization and thus increases the lifetime of the active drug in vivo. | 03-03-2016 |
20160051385 | Porous Bidirectional Bellowed Tracheal Reconstruction Device - Implantable splinting devices for supporting a passageway defect in a patient that is formed from one or more support structures including a polymer or a polymer and acellularized tissue matrix that define a structural component that substantially conforms to a defective passageway of the patient. The structural component also has a plurality of pores. The implantable splinting device is capable of being placed around a trachea, a bronchi, an esophagus and a blood vessel of a patient. The implantable splinting device may also be configured for placement between the trachea, and the esophagus of a patient. | 02-25-2016 |
20160031973 | TREATMENT OF STAPHYLOCOCCAL DISORDERS - Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation. | 02-04-2016 |
20160020418 | STABLE ORGANIC PHOTOSENSITIVE DEVICES WITH EXCITON-BLOCKING CHARGE CARRIER FILTERS UTILIZING HIGH GLASS TRANSITION TEMPERATURE MATERIALS - Disclosed herein are stable organic photosensitive devices including at least one exciton-blocking charge carrier filter. The filters comprise a mixture of at least one wide energy gap material having a sufficiently high glass transition temperature, e.g., higher than the temperature or temperature range at which the device typically operates, higher than a highest operating temperature of the device, higher than a threshold temperature value, etc. and at least one electron or hole conducting material. As described herein, the novel filters simultaneously block excitons and conduct the desired charge carrier (electrons or holes). | 01-21-2016 |
20160006002 | ORGANIC ELECTRONIC DEVICES WITH MULTIPLE SOLUTION-PROCESSED LAYERS - A method for fabricating an organic light emitting device stack involves depositing a first conductive electrode layer over a substrate; depositing a first set of one or more organic layers, wherein at least one of the first set of organic layers is a first emissive layer and one of the first set of organic layers is deposited by a solution-based process that utilizes a first solvent; depositing a first conductive interlayer by a dry deposition process; and depositing a second set of one or more organic layers, wherein at least one of the second set of organic layers is a second emissive layer and one of the second set of organic layers is deposited by a solution-based process that utilizes a second solvent, wherein all layers that precede the layer deposited using the second solvent are insoluble in the second solvent. | 01-07-2016 |
20160005983 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME - There is disclosed squaraine compounds of formula I: | 01-07-2016 |
20160000865 | COMPOSITIONS AND METHODS RELATING TO INDUCTION OF INTESTINAL STEM CELL HOMEOGENESIS AND/OR REGENERATION - The present invention relates to compositions and methods for inducing intestinal stem cell homeogenesis and/or regeneration within intestinal tissue expressing Robo1 through administration of a Rspo1 agent and a Slit2 agent. Administration of such agents results in, for example, binding of the Rspo1 agent and Slit2 agent with Robo1, resulting in, for example, binding of the CC3 motif of Robo1 with LRP6, resulting in phosphorylation of LRP6, and ultimately, induction of intestinal stem cell homeogenesis and/or regeneration. In certain embodiments, such administration of a Rspo1 agent and a Slit2 agent is used to protect and/or prevent intestinal tissue damage resulting from exposure to an intestinal tissue damaging event (e.g., radiation). The agents and related compositions additionally find use in diagnostic and research settings. | 01-07-2016 |
20150369771 | CO-ELECTRODEPOSITED HYDROGEL-CONDUCTING POLYMER ELECTRODES FOR BIOMEDICAL APPLICATIONS - Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer. | 12-24-2015 |
20150367005 | METHOD OF SYNTHESIZING FLUORINE-18 LABELED RADIOPHARMACEUTICALS IN ETHANOL AND WATER - A method of preparing fluorine-18 labeled radiopharmaceuticals ( | 12-24-2015 |
20150366831 | THROMBORESISTANT/BACTERICIDAL S-NITROSO-N-ACETYLPENICILLAMINE (SNAP)-DOPED NITRIC OXIDE RELEASE POLYMERS WITH ENHANCED STABILITY - A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct. | 12-24-2015 |
20150364753 | CONTROLLED POROSITY IN ELECTRODES - Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries, and can include low tortuosity in the primary direction of ion transport during charge and discharge of the battery. In some embodiments, the electrodes can have a high volume fraction of electrode active material (i.e., low porosity). The attributes outlined above can allow the electrodes to be fabricated with a higher energy density, higher capacity per unit area of electrode (mAh/cm | 12-17-2015 |
20150357366 | NON-PLANAR INORGANIC OPTOELECTRONIC DEVICES - A device includes a three-dimensionally curved substrate, a patterned metal layer disposed on the curved substrate, and an array of optoelectronic devices, each optoelectronic device including an optoelectronic structure supported by the curved substrate. Each optoelectronic structure includes an inorganic semiconductor stack. The device further includes a set of contact stripes extending across the curved substrate, each optoelectronic structure being coupled to a respective contact stripe of the set of contact stripes. The array of optoelectronic devices is secured to the curved substrate via a bond between the patterned metal layer and the set of contact stripes. | 12-10-2015 |
20150349283 | HYBRID PLANAR-MIXED HETEROJUNCTION FOR ORGANIC PHOTOVOLTAICS - Disclosed herein are organic photosensitive optoelectronic devices comprising two electrodes in superposed relation; a mixed photoactive layer located between the two electrodes, wherein the mixed photoactive layer comprises at least one donor material having a HOMO energy and at least one acceptor material having a LUMO energy, wherein the at least one donor material and the at least one acceptor material form a mixed donor-acceptor heterojunction; a photoactive layer adjacent to and interfacing with the mixed photoactive layer, wherein the photoactive layer comprises a material having a LUMO energy within 0.3 eV of the LUMO energy of the at least one acceptor material or a HOMO energy within 0.3 eV of the HOMO energy of the at least one donor material; and a buffer layer adjacent to and interfacing with the mixed photoactive layer. | 12-03-2015 |
20150344036 | VEHICLE SPEED PROFILE PREDICTION USING NEURAL NETWORKS - A vehicle includes a powertrain having an electric machine and an engine. The vehicle also includes a controller programmed to operate the powertrain according to a predicted vehicle speed profile for a predetermined route segmented according to a group of driving zone types, wherein each driving zone type is associated with a different characteristic speed profile shape and vehicle location. The controller is further programmed to update the predicted speed profile for a those segments showing deviation in response to deviation between the predicted speed profile and a measured speed profile. | 12-03-2015 |
20150340634 | HYBRID PLANAR-GRADED HETEROJUNCTION FOR ORGANIC PHOTOVOLTAICS - Disclosed herein are organic photosensitive optoelectronic devices comprising at least one hybrid planar-graded heterojunction. In particular, organic photosensitive optoelectronic devices are disclosed having two electrodes ( | 11-26-2015 |
20150336994 | BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed. | 11-26-2015 |
20150328315 | SYSTEMS AND METHODS FOR TARGETED IMAGING AND ABLATION OF CARDIAC CELLS - The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent. | 11-19-2015 |
20150318505 | USE OF INVERSE QUASI-EPITAXY TO MODIFY ORDER DURING POST-DEPOSITION PROCESSING OR ORGANIC PHOTOVOLTAICS - Disclosed herein are methods for fabricating an organic photovoltaic device comprising depositing an amorphous organic layer and a crystalline organic layer over a first electrode, wherein the amorphous organic layer and the crystalline organic layer contact one another at an interface; annealing the amorphous organic layer and the crystalline organic layer for a time sufficient to induce at least partial crystallinity in the amorphous organic layer; and depositing a second electrode over the amorphous organic layer and the crystalline organic layer. In the methods and devices herein, the amorphous organic layer may comprise at least one material that undergoes inverse-quasi epitaxial (IQE) alignment to a material of the crystalline organic layer as a result of the annealing. | 11-05-2015 |
20150316511 | REAL-TIME DETECTION AND IMAGING OF TERAHERTZ PULSE RADIATION BY USING PHOTOACOUSTIC CONVERSION - Methods and devices for high speed detection of terahertz radiation are provided. A photoacoustic transducer receives a pulse of terahertz (THz) radiation. The transducer may comprise a solid, liquid, or semi-solid material. For example, the transducer may be a composite material having a polymer and radiation absorbing particles. The photoacoustic transducer produces an acoustic wave (e.g., an ultrasound wave) in response to receiving the pulse of THz radiation. An acoustic sensor receives the acoustic wave produced by the photoacoustic transducer and thus provides detection of the THz wave. | 11-05-2015 |
20150309133 | METHOD OF MRI IMAGING USING A SPECTRALLY DESIGNED PULSE - A system and method for acquiring image data from an object that includes a plurality of spins is described. A magnetic field is applied to the object to align the spins along a longitudinal axis. A first pulse is applied to the spins for rotating the spins from the longitudinal axis toward a transverse plane. Image data is acquired from the spins during a free precession interval in which the spins precess in the transverse plane. A second pulse is applied to the spins for rotating the spins from the transverse plane to at least substantially along the longitudinal axis. At least one of the first and second pulses is spectrally or spectrally-spatially designed. | 10-29-2015 |
20150302844 | PROCESSING A STREAM OF ORDERED INPUT DATA - A data processing system is provided for performing processing operations upon an ordered stream of input data values to form an ordered stream of output data values. A select circuit ( | 10-22-2015 |
20150301195 | PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS AND METHOD FOR IMPROVING TOPOLOGICAL UNIFORMITY OF THE PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS BASED ON THIN-FILM ELECTRONICS - A radiation sensor including a scintillation layer configured to emit photons upon interaction with ionizing radiation and a photodetector including in order a first electrode, a photosensitive layer, and a photon-transmissive second electrode disposed in proximity to the scintillation layer. The photosensitive layer is configured to generate electron-hole pairs upon interaction with a part of the photons. The radiation sensor includes pixel circuitry electrically connected to the first electrode and configured to measure an imaging signal indicative of the electron-hole pairs generated in the photosensitive layer and a planarization layer disposed on the pixel circuitry between the first electrode and the pixel circuitry such that the first electrode is above a plane including the pixel circuitry. A surface of at least one of the first electrode and the second electrode at least partially overlaps the pixel circuitry and has a surface inflection above features of the pixel circuitry. The surface inflection has a radius of curvature greater than one half micron. | 10-22-2015 |
20150299881 | DEVICES AND METHODS FOR SPATIALLY AND TEMPORALLY RECONFIGURABLE ASSEMBLY OF COLLOIDAL CRYSTALS - The disclosure provides devices and methods for controlled assembly of colloidal particles. A medium with colloidal particles having a charged surface is placed in physical contact with an electrically conductive material (e.g., an ITO coating). An external light source directs light towards the electrically conductive material, thus driving the colloidal particles from a first non-assembled state to a second assembled state, which may thus create organized colloidal crystals or alternatively predetermined void regions. Assembly of the colloids can be achieved with no external electric fields or external magnetic fields. Moreover, the colloidal assembly is three-dimensional, occurs rapidly, and is entirely reversible and reconfigurable based on controlling the light applied to the electrically conductive material. | 10-22-2015 |
20150299211 | MDM2 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of MDM2 and MDM2-related proteins and compositions containing the same are disclosed. Methods of using the MDM2 inhibitors in the treatment of diseases and conditions wherein inhibition of an interaction between p53 and MDM2 provides a benefit, like cancers, also are disclosed. | 10-22-2015 |
20150287950 | Stacked White OLED Having Separate Red, Green and Blue Sub-Elements - The present invention relates to efficient organic light emitting devices (OLEDs). More specifically, the present invention relates to white-emitting OLEDs, or WOLEDs. The devices of the present invention employ three emissive sub-elements, typically emitting red, green and blue, to sufficiently cover the visible spectrum. The sub-elements are separated by charge generating layers. | 10-08-2015 |
20150284802 | ncRNA AND USES THEREOF - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer. | 10-08-2015 |
20150280149 | FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS - A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process. By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,β fashion is achieved resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins. | 10-01-2015 |
20150277925 | DATA PROCESSING APPARATUS AND METHOD FOR EXECUTING A STREAM OF INSTRUCTIONS OUT OF ORDER WITH RESPECT TO ORIGINAL PROGRAM ORDER - A data processing apparatus and method are provided for executing a stream of instructions out-of-order with respect to original program order. At least some of the instructions in the stream identify one or more architectural registers from a set of architectural registers. The apparatus comprises a plurality of out-of-order components configured to manage execution of a first subset of instructions out-of-order, the plurality of out-of-order components being configured to remove false dependencies between instructions in the first subset. The plurality of out-of-order components include a first issue queue into which the instructions in the first subset are buffered prior to execution. A second issue queue is used to buffer a second subset of instructions prior to execution, the second subset of instructions being constrained to execute in order. Issue control circuitry is configured to reference both issue queues in order to determine an order of execution of instructions, and is configured to constrain the order of execution of the first subset of instructions by true dependencies between the instructions in both the first and second issue queues, and to constrain the order of execution of the second subset of instructions by both the true dependencies and the false dependencies between the instructions in both the first and second issue queues. This approach provides improved performance and/or reduced energy consumption. | 10-01-2015 |
20150268293 | System and Method for Statistical Post-Silicon Validation - The system and method described herein relate to a bug positioning system for post-silicon validation of a prototype integrated circuit using statistical analysis. Specifically, the bug positioning system samples output and intermediate signals from a prototype chip to generate signatures. Signatures are grouped into passing and failing groups, modeled, and compared to identify patterns of acceptable behavior and unacceptable behavior and locate bugs in space and time. | 09-24-2015 |
20150268232 | Functionalized Polydiacetylene Sensors - A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence. | 09-24-2015 |
20150265848 | CANCER STEM CELL VACCINATION AND TREATMENT - The present invention relates to methods, systems, and compositions for treating and preventing cancer in a subject with the combination of radiation therapy and antigen presenting cells that have been exposed cancer stem cells or a portion thereof. In certain embodiments, the antigen presenting cells are dendritic cells that have been pulsed with ALDH | 09-24-2015 |
20150260170 | SYSTEM WITH DAMPER-CONTROLLED SWITCH FOR SHAPE MEMORY ALLOY ACTUATOR MOTION CONTROL - A system for controlling motion of a shape memory alloy (SMA) actuator includes a damper operatively connectable to the SMA actuator and having a movable portion that moves with the SMA actuator when the SMA actuator contracts during electrical activation. An electronic switch is operatively connectable to the SMA actuator and to the damper. The electronic switch has an open position preventing electrical power flow to the SMA actuator, and a closed position permitting electrical power flow to the SMA actuator. A biasing element applies a biasing force that urges the electronic switch to the closed position. The damper overcomes the biasing element to move the switch to the open position only when velocity of the movable portion equals or exceeds a predetermined threshold velocity, and to return to the closed position when the velocity of the movable portion falls below the predetermined threshold velocity. | 09-17-2015 |
20150258052 | METHODS OF USING FEXARAMINE AND AGENTS THAT INCREASE SYMPATHETIC NERVOUS SYSTEM ACTIVITY TO PROMOTE BROWNING OF WHITE ADIPOSE TISSUE - Provided are methods of promoting browning of white adipose tissue (WAT) in a subject. Such methods can include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of fexaramine in combination with a therapeutically effective amount of a compound that mimics or increases sympathetic nervous system activity (e.g., one or more beta-adrenergic agonists and/or compounds that increase epinephrine secretion). | 09-17-2015 |
20150253169 | FLUID FLOW SENSOR - A fluid flow sensor that utilizes hot-wire anemometry and is a small, light weight, cost effective, easily manufactureable, and low power consuming device. The fluid flow sensor operates by exposing a hot wire loop to a fluid stream such that the amount of heat lost to fluid convection is a function of one or more fluid-related parameters (e.g., fluid speed, fluid type, fluid density, etc.). The heat loss affects the resistance in the wire loop, which can then be used to estimate the fluid speed or other fluid-related parameter. According to an exemplary embodiment, the fluid flow sensor includes one or more wire loops that are made from pre-formed wires and are wire bonded, micro-welded or otherwise non-monolithically attached to a substrate that may or may not include embedded sensor circuitry. | 09-10-2015 |
20150252350 | SPONTANEOUSLY FORMED TERMINAL SUPRAPARTICLES HAVING NANOPARTICLES FOR PROTEIN STABILIZATION - Supraparticle nanoassemblies are provided that comprise nanoparticle species and protein species, as well as methods for making such assemblies. A supraparticle may comprise a nanoparticle species with a first charge and an average particle size diameter of ≧about 1 nm to ≦about 100 nm. The supraparticle also comprises a protein species. The nanoparticle species and the protein species have the same charge and are assembled together without any intramolecular chemical bonding to form the supraparticle. The supraparticle may be a substantially round particle. In certain other aspects, a photoreactive supraparticle is provided, where the nanoparticle is reactive to energy or electromagnetic radiation, which in the presence of such energy or radiation enhances reactivity of the protein species in the supraparticle. | 09-10-2015 |
20150246923 | 9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS - The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: | 09-03-2015 |
20150246815 | PURIFICATION OF CARBON NANOTUBES USING AGAROSE COLUMN AND DENSITY GRADIENT ULTRACENTRIFUGATION - A method of processing bundles of carbon nanotubes (CNTs). Bundles of CNTs are put into a solution and unbundled using sonication and one or more surfactants that break apart and disperse at least some of the bundles into the solution such that it contains individual semiconducting CNTs, individual metallic CNTs, and remaining CNT bundles. The individual CNTs are separated from each other using agarose bead column separation using sodium dodecyl sulfate as a surfactant. Remaining CNT bundles are then separated out by performing density-gradient ultracentrifugation. | 09-03-2015 |
20150231394 | COCHLEAR IMPLANT - A device for implantation into a scalia tympani of a cochlea is disclosed. The device comprises blocks and compliant elements interconnecting the blocks with one of the compliant elements disposed between each pair of adjacent blocks. The compliant elements impart flexibility to the device in a plane of curvature of the cochlea and impart stiffness to the device out of the plane of curvature of the cochlea. The device further comprises piezoelectric elements with at least one of the elements disposed the blocks. Each piezoelectric element comprises at least one piezoelectric sensing unit and at least one electrode for transmitting the electrical signal to the auditory nerve. The device further comprises communication lines for transmitting an electrical signal through the device with one of the communication lines disposed between each pair of blocks and parallel to the compliant element. | 08-20-2015 |
20150226800 | MEASUREMENT CIRCUITRY AND METHOD FOR MEASURING A CLOCK NODE TO OUTPUT NODE DELAY OF A FLIP-FLOP - A measurement circuit and method are provided for measuring a clock node to output node delay of a flip-flop. A main ring oscillator has a plurality of main unit cells arranged in a ring, with each main unit cell comprising a flip-flop and pulse generation circuitry connected to the output node of the flip-flop. The flip-flop is responsive to receipt of an input clock pulse at the clock node to output a data value transition from the output node, and the pulse generation circuitry then generates from the data value transition an input clock pulse for a next main unit cell in the main ring, whereby the main ring oscillator generates a first output signal having a first oscillation period. A reference ring oscillator has a plurality of reference unit cells arranged to form a reference ring, and generates a second output signal having a second oscillation period, each reference unit cell comprising components configured such that the second oscillation period provides an indication of a propagation delay through the pulse generation circuitry of the main unit cells of the main ring during the first oscillation period. Calculation circuitry then determines the clock node to output node delay of the flip-flop from the first oscillation period and the second oscillation period. This provides a particularly simple and accurate mechanism for calculating the clock node to output node delay of a flip-flop. | 08-13-2015 |
20150223753 | BALL JOINT CENTER LOCATING METHOD USING DATA FROM ATTACHED INERTIAL MEASUREMENT UNIT - A method for calculating the location of the center-of-rotation of a joint with an attached member. The method employs an inertial measurement unit (IMU) having an angular rate gyro and an accelerometer and coupling the inertial measurement unit to the member for detection of movement of the member. The inertial measurement unit outputs data representative of angular velocity and acceleration of the member mounted IMU in response to movement of the joint. The method further comprising analyzing the angular rate and acceleration data to determine the center-of-rotation of the joint. | 08-13-2015 |
20150220440 | ORDERING CONSTRAINT MANAGEMENT WITHIN COHERENT MEMORY SYSTEMS - A data processing system including multiple processors | 08-06-2015 |
20150207508 | LEVEL CONVERSION CIRCUIT - A level conversion circuit has a keeper circuit for retaining an intermediate output node at a high output level to avoid it floating due to leakage through a pullup transistor in a shifting circuit. Thin oxide and thick oxide versions of the level conversion circuit can be provided. The level conversion circuit enables higher performance, reduced power consumption and reduced susceptibility to process variation compared to previous level conversion designs. | 07-23-2015 |
20150155395 | SCHOTTKY DIODE AND METHOD OF FABRICATING THE SAME - Provided is a Schottky diode. The Schottky diode includes: a substrate; a core on the substrate; a metallic layer on the core; and a shell surrounding the core between the metallic layer and the substrate and adjusting a Fermi energy level of the core to form a Schottky junction between the core and the metallic layer. | 06-04-2015 |
20150155014 | MEMORY CIRCUITRY INCLUDING READ VOLTAGE BOOST - Memory circuitry | 06-04-2015 |
20150154106 | DATA PROCESSING APPARATUS WITH MEMORY RENAME TABLE FOR MAPPING MEMORY ADDRESSES TO REGISTERS - A data processing apparatus has a memory rename table for storing memory rename entries each identifying a mapping between a memory address of a location in memory and a mapped register of a plurality of registers. The mapped register is identified by a register number. In response to a store instruction, the store target memory address of the store instruction is mapped to a store destination register and so the data value is stored to the store destination register instead of memory. A memory rename entry is provided in the table to identify the mapping between the store target memory address and store destination target register. In response to a load instruction, if there is a hit in the memory rename table for the load target memory address then the loaded value can be read from the mapped register instead of memory. | 06-04-2015 |
20150154096 | VERIFICATION OF COMPLEX SYSTEMS THAT CAN BE DESCRIBED BY A FINITE STATE TRANSITION SYSTEM - A method including the steps of: generating a system model, the model comprising an initial state, a transition between consecutive states and a property function defining a property that should be met for an allowable state, the initial state, transition function and property function each comprising at least one of data, operations and predicates; generating an abstracted model by approximating at least some of the data, operations and predicates with uninterpreted terms, functions and predicates respectively, to generate at least one abstracted initial state, abstracted transition function and abstracted property function within the abstracted model; performing a complete reachability analysis on the abstracted model to determine whether the system can reach an unallowable abstracted state by following the abstracted transition function; and if not, the system is verified as correct; and if so, unabstracting a trace of the transitions from the abstracted initial state to the unallowable abstracted state. | 06-04-2015 |
20150154021 | CONTROL OF SWITCHING BETWEEN EXECUTION MECHANISMS - An apparatus | 06-04-2015 |
20150154006 | TRUE RANDOM NUMBER GENERATOR - A true random number generator comprises a ring oscillator which is triggered to start oscillating in a first mode of oscillation at an oscillation start time. The first mode of oscillation will eventually collapse to a second mode of oscillation dependent on thermal noise. A collapse time from the oscillation start time to the time at which the oscillator collapses to the second mode is measured, and this can be used to determine a random number. The TRNG can be synthesized entirely using standard digital techniques and is able to provide high randomness, good throughput and energy efficiency. | 06-04-2015 |
20150146475 | MEMORY SENSE AMPLIFIER WITH MULTIPLE MODES OF OPERATION - Memory circuitry comprising an array of 6T bit cells | 05-28-2015 |
20150140214 | NOZZLE GEOMETRY FOR ORGANIC VAPOR JET PRINTING - A first device is provided. The device includes a print head. The print head further includes a first nozzle hermetically sealed to a first source of gas. The first nozzle has an aperture having a smallest dimension of 0.5 to 500 microns in a direction perpendicular to a flow direction of the first nozzle. At a distance from the aperture into the first nozzle that is 5 times the smallest dimension of the aperture of the first nozzle, the smallest dimension perpendicular to the flow direction is at least twice the smallest dimension of the aperture of the first nozzle. | 05-21-2015 |
20150139935 | SLEEP APNEA TREATMENT - Provided herein is technology relating to treating sleep apnea and particularly, but not exclusively, to treating sleep apnea with immunotherapeutics and/or anti-inflammatory drugs such as beta-interferons and glatiramer acetate. | 05-21-2015 |
20150121048 | HETEROGENEITY WITHIN A PROCESSOR CORE - A processor core includes a front end, and first and second back ends, the front end including a fetch engine configured to retrieve the sequence of data processing instructions for both the first back end and the second back end from a memory, and the first and second back ends are each configured to execute the sequence of program instructions. The core operates in a first mode in which the first back end is active and receives the sequence of data processing instructions from the fetch engine and the second back end is inactive, and a second mode in which the first back end is inactive and the second back end is active and receives the sequence of data processing instructions from the fetch engine, where the cycles-per-instruction rate is lower and energy consumption is higher for the first mode than the second mode. | 04-30-2015 |
20150120093 | ICE AND WATER DETECTION SYSTEM - A system for detecting ice or water within an area of interest having a detection system measuring radiance or reflectance of the area of interest when exposed to shortwave infrared radiation having a wavelength in the range containing a crossover point between the curves representing the absorption of electromagnetic radiation by ice and water. The detection system measures the radiance or reflectance in a first band having a wavelength in a spectral band on a first side of the crossover point and outputting a first band signal, and further measures the radiance or reflectance in a second band having a wavelength in a spectral band on a second opposing side of the same crossover point and outputting a second band signal. A processing unit determines a ratio of the first band signal and the second band signal and compares the ratio to a predetermined critical ratio and outputs a determination signal indicating presence of ice or water. | 04-30-2015 |
20150120092 | ICE AND SUPERCOOLED WATER DETECTION SYSTEM - A system for detecting ice or supercooled large droplets within an area of interest having a detection system measuring radiance or reflectance of the area of interest when exposed to shortwave infrared radiation having a wavelength in the range of about 2.05 μm to about 2.30 μm. The detection system measures the radiance or reflectance in a first band having a wavelength in the range of about 2.05 μm to about 2.15 μm and outputting a first band signal, and further measures the radiance or reflectance in a second band having a wavelength in the range of about 2.15 μm to about 2.30 μm and outputting a second band signal. A processing unit determines a ratio of the first band signal and the second band signal and compares the ratio to a predetermined critical ratio and outputs a determination signal indicating presence of ice or supercooled water droplets. | 04-30-2015 |
20150118516 | Composite Metal Alloy Material - An alloy composite material comprising an aluminum alloy layer and a thermal spray alloy layer of 20 to 40% Mn and 47 to 76% Fe by weight in overlaying contact with the aluminum alloy layer. An alloy composite material comprising an aluminum alloy layer or base layer and a thermal spray alloy layer of 20 to 40% Mn and 47 to 76% Fe by weight in overlaying contact with the aluminum alloy layer or base layer. The aluminum alloy layer or base layer and the thermal spray alloy layer have a mechanical compatibility to each other of 20-60 MPa as determined using tests specified by ASTM-C633 test. A process of thermal spraying comprising providing a base layer and a feed stock alloy of 20 to 40% Mn and 47 to 76% Fe and thermally spraying the feed stock alloy onto the base layer to form an alloy composite material. | 04-30-2015 |
20150094189 | REGENERATIVE DIFFERENTIAL POWERTRAIN WITH VIBRATION ABSORPTION AND ISOLATION - A vehicular system includes a crankshaft, a drive shaft, a plurality of electromagnetic machines mechanically coupling the crankshaft to the drive shaft, a power controller electrically coupled to the plurality of electromagnetic machines and configured to control current and/or voltage provided to, or received from, each electromagnetic machine of the plurality of electromagnetic machines, a supervisory controller communicatively coupled with the power controller and configured to establish an operational mode for the power controller, and a storage device electrically coupled to the power controller to store energy captured by the power controller. | 04-02-2015 |
20150065530 | BIOMARKER ASSOCIATED WITH IRRITABLE BOWEL SYNDROME AND CROHN'S DISEASE - The present invention provides compositions and methods for characterizing irritable bowel syndrome. In particular, the present invention provides compositions and methods for determining polymorphisms associated with IBS-D and Crohn's disease. The present invention further provides compositions and methods for determining a treatment course of action in subjects with IBS-D and Crohn's disease. | 03-05-2015 |
20150064628 | METHODS FOR MAKING MICRO- AND NANO-SCALE CONDUCTIVE GRIDS FOR TRANSPARENT ELECTRODES AND POLARIZERS BY ROLL TO ROLL OPTICAL LITHOGRAPHY - Methods of micro- and nano-patterning substrates to form transparent conductive electrode structures or polarizers by continuous near-field optical nanolithography methods using a roll-type photomask or phase-shift mask are provided. In such methods, a near-field optical nanolithography technique uses a phase-shift or photo-mask roller that comprises a rigid patterned externally exposed surface that transfers a pattern to an underlying substrate. The roller device may have an internally disposed radiation source that generates radiation that passes through the rigid patterned surface to the substrate during the patterning process. Sub-wavelength resolution is achieved using near-field exposure of photoresist material through the cylindrical rigid phase-mask, allowing dynamic and high throughput continuous patterning. | 03-05-2015 |
20150048314 | PHOTOACTIVE DEVICES INCLUDING PORPHYRINOIDS WITH COORDINATING ADDITIVES - Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both. | 02-19-2015 |
20150045357 | SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF - This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases. | 02-12-2015 |
20150025045 | CBP AND p300-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS - The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating p300 and/or CBP-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant p300 and/or CBP-mediated transcription with p300 and/or CBP-mediated transcription modulators (e.g., p300 and/or CBP-mediated transcription inhibitors). | 01-22-2015 |
20150017156 | ESX-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS - The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating ESX-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant EGFR expression with ESX-mediated transcription modulators (e.g., ESX-mediated transcription inhibitors). | 01-15-2015 |
20140379219 | TRAILER BACKUP ASSIST CURVATURE CONTROL - A vehicle has a trailer backup steering input apparatus, a trailer backup assist control module coupled to the a trailer backup steering input apparatus, and an electric power assist steering system coupled to the trailer backup assist control module and. The trailer backup steering input apparatus is configured for outputting a trailer path curvature signal approximating a desired curvature for a path of travel of a trailer towably coupled to the vehicle. The trailer backup assist control module is configured for determining vehicle steering information as a function of the trailer path curvature signal. The electric power assist steering system is configured for controlling steering of steered wheels of the vehicle as a function of the vehicle steering information. | 12-25-2014 |
20140364679 | Multi-Coil Transcranial Magnetic Stimulation - An improved apparatus is provided for transcranial magnetic stimulation in a brain of a subject. The apparatus is comprised of: a plurality of coils electrically connected in series to each other; and a single source of current electrically coupled to one of the plurality of coils. Each coil may include one or more windings of similar dimensions although the size of the windings varies between coils. Each of the coils is further dimensioned to stimulate brain tissue at a given distance while minimizing volume of the brain tissue excited by the magnetic field. During operation, the current source injects time varying current into the coils to create a magnetic field which in turn induces electric fields and eddy-currents inside the brain tissue of the subject. | 12-11-2014 |
20140364481 | RNA CHIMERAS IN HUMAN LEUKEMIA AND LYMPHOMA - Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent RNA fusions as diagnostic markers and clinical targets for leukemia. | 12-11-2014 |
20140361271 | Stacked White OLED Having Separate Red, Green and Blue Sub-Elements - The present invention relates to efficient organic light emitting devices (OLEDs). More specifically, the present invention relates to white-emitting OLEDs, or WOLEDs. The devices of the present invention employ three emissive sub-elements, typically emitting red, green and blue, to sufficiently cover the visible spectrum. The sub-elements are separated by charge generating layers. | 12-11-2014 |
20140348813 | THERMOSTABILIZATION OF PROTEINS - Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition. | 11-27-2014 |
20140343321 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels. | 11-20-2014 |
20140336503 | RADIOLABELED BIOMARKERS FOR OSTEOCLAST ACTIVATION AND RELATED METHODS THEREOF - The present invention provides biomarkers that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging). In particular, the present invention provides methods for identifying and characterizing osteoclast activation within subjects with radiolabeled cathepsin K inhibitors. | 11-13-2014 |
20140329848 | DEUTERATED AMLEXANOX - Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox. | 11-06-2014 |
20140326972 | PHOSPHORESCENT ORGANIC LIGHT EMITTING DIODES WITH HIGH EFFICIENCY AND BRIGHTNESS - An organic light emitting device including a) an anode; b) a cathode; and c) an emissive layer disposed between the anode and the cathode, the emissive layer comprising an organic host compound and a phosphorescent compound exhibiting a Stokes Shift overlap greater than 0.3 eV. The organic light emitting device may further include a hole transport layer disposed between the emissive layer and the anode; and an electron transport layer disposed between the emissive layer and the cathode. In some embodiments, the phosphorescent compound exhibits a phosphorescent lifetime of less than 10 μs. In some embodiments, the concentration of the phosphorescent compound ranges from 0.5 wt. % to 10 wt. %. | 11-06-2014 |
20140322729 | SERS, FLUORESCENCE, ABSORPTION, AND LUMINESCENCE DETECTION WITH FLOW-THROUGH MULTI-HOLE CAPILLARIES - 3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved. | 10-30-2014 |
20140322712 | DIAGNOSIS AND TREATMENT OF MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the biomarkers and related compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 10-30-2014 |
20140316266 | LUNG VENTILLATION MEASUREMENTS USING ULTRASOUND - An ultrasound-based system determines dynamic strain measurements over a surface using ultrasound speckle analysis that allows for accurate measurement of surface area displacement. The system additionally determines an approximate displacement along a third axis, the z-axis. From these, an estimation of a local volume change is determined. In this way, a volume change can be determined for the lung or any other region of interest. | 10-23-2014 |
20140313795 | SINGLE PHASE BI-DIRECTIONAL AC-DC CONVERTER WITH REDUCED PASSIVE COMPONENTS SIZE AND COMMON MODE ELECTRO-MAGNETIC INTERFERENCE - A bidirectional AC-DC converter is presented with reduced passive component size and common mode electro-magnetic interference. The converter includes an improved input stage formed by two coupled differential inductors, two coupled common and differential inductors, one differential capacitor and two common mode capacitors. With this input structure, the volume, weight and cost of the input stage can be reduced greatly. Additionally, the input current ripple and common mode electro-magnetic interference can be greatly attenuated, so lower switching frequency can be adopted to achieve higher efficiency. | 10-23-2014 |
20140306199 | CONCAVE-HEMISPHERE-PATTERNED ORGANIC TOP-LIGHT EMITTING DEVICE - A first device is provided. The first device includes an organic light emitting device, which further comprises a first electrode, a second electrode, and an organic emissive layer disposed between the first and second electrode. Preferably, the second electrode is more transparent than the first electrode. The organic emissive layer has a first portion shaped to form an indentation in the direction of the first electrode, and a second portion shaped to form a protrusion in the direction of the second electrode. The first device may include a plurality of organic light emitting devices. The indentation may have a shape that is formed from a partial sphere, a partial cylinder, a pyramid, or a pyramid with a mesa, among others. The protrusions may be formed between adjoining indentations or between an indentation and a surface parallel to the substrate. | 10-16-2014 |
20140298990 | DEVICES AND METHODS FOR ADAPTIVE MICRO-GAS CHROMATOGRAPHY - The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings. | 10-09-2014 |
20140297008 | ATHLETE SPEED PREDICTION METHOD USING DATA FROM ATTACHED INERTIAL MEASUREMENT UNIT - An apparatus and method for calculating athlete speed non-invasively, on the field/court of play using data from a torso-mounted inertial measurement unit. The method complements existing, GPS-based methods for calculating athlete speed by enabling use in environments where GPS signal is unavailable (i.e. indoors). | 10-02-2014 |
20140296551 | CONJUGATED GOLD NANOPARTICLES - The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic) | 10-02-2014 |
20140294672 | NITRIC OXIDE DELIVERY DEVICES - An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood. | 10-02-2014 |
20140288458 | INSERTABLE NEURAL PROBE WITH FLEXIBLE STRUCTURE - A neural probe ( | 09-25-2014 |
20140283604 | THREE-DIMENSIONAL MICROELECTROMECHANICAL SYSTEMS STRUCTURE - A three-dimensional microelectromechanical systems (MEMS) structure includes a substrate and having a height extending outwardly from the substrate and a largest lateral dimension orthogonal to the height. The largest lateral dimension is smaller than the height. A transducing element is operatively connected to the hair-like core and embedded within, formed on an outer surface of, or disposed at a root of the hair-like core. The transducing element is to receive an electrical core signal or a non-electrical core signal conveyed by the hair-like core. The transducing element is to convert the non-electrical core signal to an electrical output signal, convert the electrical core signal to an electrical output signal in a different format, convert the non-electrical core signal to a different non-electrical output signal, or convert the electrical core signal to a non-electrical output signal. | 09-25-2014 |
20140275737 | PERSONALIZED AUDITORY-SOMATOSENSORY STIMULATION TO TREAT TINNITUS - Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus. | 09-18-2014 |
20140275169 | Combination Therapies for Enhancing Protein Degradation - Disclosed herein are combination therapies for enhancing protein degradation. One component is an inhibitor of USP14, while the second component is an inhibitor of Hsp70. In certain embodiments, the invention relates to methods of treating or preventing a tauopathy, such as Alzheimer's disease. | 09-18-2014 |
20140275070 | COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF - The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1 and MLL2 or menin). | 09-18-2014 |
20140268332 | DYE AND PIGMENT-FREE STRUCTURAL COLORS AND ANGLE-INSENSITIVE SPECTRUM FILTERS - Optical spectrum filtering devices displaying minimal angle dependence or angle insensitivity are provided. The filter comprises a localized plasmonic nanoresonator assembly having a metal material layer defining at least one nanogroove and a dielectric material disposed adjacent to the metal material layer. The dielectric material is disposed within the nanogroove(s). The localized plasmonic nanoresonator assembly is configured to funnel and absorb a portion of an electromagnetic spectrum in the at least one nanogroove via localized plasmonic resonance to generate a filtered output having a predetermined range of wavelengths that displays angle insensitivity. Thus, flexible, high efficiency angle independent color filters having very small diffraction limits are provided that are particularly suitable for use as pixels for various display devices or for use in anti-counterfeiting and cryptography applications. The structures can also be used for colored print applications and the elements can be rendered as pigment-like particles. | 09-18-2014 |
20140268319 | COMPACT LENS SYSTEM AND ARRAY - A compact lens system for imaging a sample comprising a substrate having a well formed therein. Index matching material is disposed in the well and a lens member is further disposed in the well in optical contact with the index matching material disposed in the well. A spacer member extends from at least one of the substrate and the lower transparent member to define a spacing from a focal point of the lens member, wherein the lens member and index matching material cooperate to image a sample disposed below the lower transparent member. | 09-18-2014 |
20140266975 | Antenna Fabrication with Three-Dimensional Contoured Substrates - An antenna includes a dielectric substrate having a three-dimensional contour, and a set of antenna traces on the dielectric substrate. Each antenna trace spirals around the three-dimensional contour in a helical pattern. Each antenna trace includes a plated metallic layer. | 09-18-2014 |
20140266053 | MULTI-DIMENSIONAL BATTERY NETWORKS FOR LARGE SCALE ENERGY STORAGE AND ELECTRICAL VEHICLE APPLICATIONS - Multi-dimensional battery networks are presented that are intrinsically superior to the standard battery networks that are currently being used in electric vehicle applications. The higher dimensional battery networks are more stable against failures in individual batteries. The networks can be implemented using Li-ion batteries and enhance the lifetime of battery networks, which is critically important, for example in automotive applications. | 09-18-2014 |
20140262830 | METHOD FOR DETERMINING TEAR GLUCOSE CONCENTRATION WITH BLOOD GLUCOSE TEST STRIPS - A method for determining glucose concentration in tear fluid includes providing a blood glucose test strip having glucose dehydrogenase as an active enzyme provided therein, receiving a tear fluid sample via fluid communication of the blood glucose test strip with an eye region of a subject, and processing the tear fluid sample to determine a tear glucose concentration. The method may further include correlating the determined tear glucose concentration with a blood glucose concentration. | 09-18-2014 |
20140256706 | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed. | 09-11-2014 |
20140255985 | TWO-PHOTON ENDOSCOPIC SCANNING ASSEMBLY FOR INFLAMMATORY DISEASE DETECTION - An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue. | 09-11-2014 |
20140255861 | METHODS AND COMPOSITIONS FOR GROWTH OF CELLS AND EMBRYONIC TISSUE ON A SYNTHETIC POLYMER MATRIX - The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix. | 09-11-2014 |
20140255397 | METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER - Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist. | 09-11-2014 |
20140249645 | HYBRID BIOELECTRICAL INTERFACE DEVICE - A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip). | 09-04-2014 |
20140248632 | Magnetically Induced Microspinning for Super-Detection and Super-Characterization of Biomarkers and Live Cells - Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker. | 09-04-2014 |
20140246596 | PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS AND METHOD FOR IMPROVING TOPOLOGICAL UNIFORMITY OF THE PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS BASED ON THIN-FILM ELECTRONICS - A radiation sensor including a scintillation layer configured to emit photons upon interaction with ionizing radiation and a photodetector including in order a first electrode, a photosensitive layer, and a photon-transmissive second electrode disposed in proximity to the scintillation layer. The photosensitive layer is configured to generate electron-hole pairs upon interaction with a part of the photons. The radiation sensor includes pixel circuitry electrically connected to the first electrode and configured to measure an imaging signal indicative of the electron-hole pairs generated in the photosensitive layer and a planarization layer disposed on the pixel circuitry between the first electrode and the pixel circuitry such that the first electrode is above a plane including the pixel circuitry. A surface of at least one of the first electrode and the second electrode at least partially overlaps the pixel circuitry and has a surface inflection above features of the pixel circuitry. The surface inflection has a radius of curvature greater than one half micron. | 09-04-2014 |
20140244130 | ON-BOARD REAL-TIME SPEED CONTROL SETPOINT VARIATION USING STOCHASTIC OPTIMIZATION - Vehicle apparatus adjusts a vehicle powertrain of the vehicle in response to a speed setpoint. An optimizer selects a control policy to periodically generate speed adjustments for applying to the speed setpoint to operate at increased efficiency. The control policy is based on a value function providing an optimized solution for a cost model and a transition probability model. The transition probability model corresponds to a driving state defined according to a plurality of dimensions including a time-of-day dimension and a geographic region dimension. The transition probability model and the control policy have inputs based on road grade and speed. The optimizer collects road grade data during routine driving of the vehicle to construct a observed transition probability model and uses divergence between the observed transition probability model and a set of predetermined transition probability models to identify a control policy for use during the routine driving. | 08-28-2014 |
20140243979 | System and Method for Forming Bone, Ligament, and Bone-Ligament Constructs - A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided. | 08-28-2014 |
20140241988 | METHODS AND COMPOSITIONS FOR TREATING ATRIAL FIBRILLATION - The present invention relates to compositions and methods for the prevention and treatment of atrial fibrillation. In particular, the present invention provides therapeutic agents for the treatment and prevention of persistent and permanent atrial fibrillation and prevention of progression of atrial fibrillation to permanent atrial fibrillation. | 08-28-2014 |
20140234624 | MICROPOROUS COORDINATION COMPLEX AND METHOD OF MAKING THE SAME - Disclosed herein is a three-dimensional coordination complex that includes a plurality of inorganic centers; a plurality of a first bis(bidentate) linker; and a plurality of a second bis(bidentate) linker, where the first and the second bis(bidentate) linkers are have different lengths, and the bidentate binding sites on each linker face in opposite directions on an axis. | 08-21-2014 |
20140212444 | COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE - The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 07-31-2014 |
20140212437 | METHODS AND COMPOSITIONS FOR TREATING ATRIAL FIBRILLATION - The present invention relates to compositions and methods for the prevention and treatment of atrial fibrillation. In particular, the present invention provides therapeutic agents for the treatment and prevention of persistent and permanent atrial fibrillation and prevention of progression of atrial fibrillation to permanent atrial fibrillation. | 07-31-2014 |
20140205586 | CONTROL OF BIOFILM FORMATION - The invention relates to control of biofilm development. Specifically, some embodiments of the present invention relate to control of bacterial biofilm formation through addition or breakdown of signal(s) that induce biofilm formation. More specifically, some embodiments of the present invention relate to control (e.g., promotion, prevention) of biofilm development by application or hydrolysis of adenosine triphospate (ATP), deoxyadenosine triphosphate (dATP), or derivatives or analogs thereof (e.g., through application or administration of an agent that hydrolyzes ATP, dATP, or derivatives or analogs thereof (e.g., apyrase)). | 07-24-2014 |
20140203066 | METHOD AND SYSTEM FOR ONLINE QUALITY MONITORING AND CONTROL OF A VIBRATION WELDING PROCESS - A method for monitoring and controlling a vibration welding system includes collecting sensory data during formation of a welded joint using sensors positioned with respect to welding interfaces of a work piece. A host machine extracts a feature set from a welding signature collectively defined by the sensory data, compares and correlates the feature set with validated information in a library, and executes a control action(s) when the present feature set insufficiently matches the information. A welding system includes a sonotrode, sensors, and the host machine. The host machine is configured to execute the method noted above. | 07-24-2014 |
20140199234 | BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed. | 07-17-2014 |
20140193858 | PRODUCTION OF VIRAL VECTORS - The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In some embodiments, the present invention provides gutted and helper viruses with identical or similar termini. In other embodiments, the present invention provides terminal protein linked adenoviral DNA. In certain embodiments, the present invention provides template extended adenoviral DNA. | 07-10-2014 |
20140193461 | STREPTOCOCCUS VACCINE COMPOSITIONS AND METHODS OF USING THE SAME - The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus | 07-10-2014 |
20140190837 | ELECTROCHEMICAL LIQUID-LIQUID-SOLID DEPOSITION PROCESSES FOR PRODUCTION OF GROUP IV SEMICONDUCTOR MATERIALS - An electrochemical liquid-liquid-solid (LLS) process that produces unlimited amounts of crystalline semiconductor, such as Ge or Si, from aqueous or polar solutions with tunable nanostructured shapes without any physical or chemical templating agent is presented. Dissolution into, saturation within, and precipitation of the semiconductor from a liquid electrode (e.g., Hg pool) or near an electrode comprising metallic nanoparticles (e.g., In nanoparticles) yields a polycrystalline semiconductor material, as deposited. Such a process can be conducted at conditions, in a single step, and under electrochemical control, while affording control over formation of a variety of material morphologies. Materials formed by such processes are also provided. | 07-10-2014 |
20140186369 | METHOD OF MODULATING NEOVASCULARIZATION - The invention provides a method of inhibiting neovascularization in a subject. The method comprises administering to the subject an agent that interferes with fibronectin (Fn) matrix assembly in an amount effective to inhibit neovascularization. The invention also provides a method of identifying an agent that inhibits neovascularization. The method comprises detecting fibronectin (Fn) matrix assembly by stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A decrease in Fn matrix assembly in the presence of the agent compared to Fn matrix assembly in the absence of the agent is indicative of an agent that inhibits neovascularization. Alternatively, the method of identifying an agent that inhibits neovascularization comprises detecting changes in nuclear architecture in stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A reduction in nuclear architecture organization identifies an agent that inhibits neovascularization. | 07-03-2014 |
20140181581 | ERROR RECOVERY WITHIN INTEGRATED CIRCUIT - An integrated circuit includes one or more portions having error detection and error correction circuits and which is operated with operating parameters giving finite non-zero error rate as well as one or more portions formed and operated to provide a zero error rate. | 06-26-2014 |
20140179561 | HANGING DROP DEVICES, SYSTEMS AND/OR METHODS - The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening. | 06-26-2014 |
20140174414 | RATE-BASED CONTRACTIVE MODEL PREDICTIVE CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE AIR PATH CONTROL - A rate based model predictive controller and method for air path control for a diesel engine regulates intake manifold pressure (MAP) and EGR valve flow rate to specified set points by coordinated control of a variable geometry turbine (VGT) and EGR valve position. A decay and a flexible Lyapunov function is enforced on the rate based model predictive controller for a single step prediction and control arisen. | 06-26-2014 |
20140174413 | RATE-BASED MODEL PREDICTIVE CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE AIR PATH CONTROL - A rate based model predictive controller for air path control for a diesel engine regulates turbine lift and EGR valve flow rate to specified set points by coordinated control of intake manifold air pressure and EGR valve flow rate. The controller utilizes a rate-based reduced order linear model for model predictive control. | 06-26-2014 |
20140162989 | MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT - The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to binary phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions. | 06-12-2014 |
20140148494 | SPIRO-OXINDOLE MDM2 ANTAGONISTS - Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. | 05-29-2014 |
20140148382 | PEPTIDE COMPOSITIONS AND METHODS FOR TREATING PATIENTS - The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome. | 05-29-2014 |
20140147510 | MULTIPHASIC POLYMERIC PARTICLES CAPABLE OF SHAPE-SHIFTING VIA ENVIRONMENTAL STIMULATION - Provided herein are methods of making and controlling multiphasic polymeric micro-components capable of shape-shifting. Such a multiphasic micro-component comprises a first phase (that can include a first polymer) and at least one additional phase distinct from said first phase (that can include a second polymer). One or more of the first phase and additional phase comprises a component that is responsive to an external stimulus. Thus, the micro-component exhibits a substantial physical deformation in response to: (i) the presence of the external stimulus or (ii) a change in the external stimulus. Exemplary external stimuli include temperature, pressure, light, pH, ionic strength, hydrophobicity/hydrophilicity, solvent, concentration, a stimulator chemical, sonic energy, electric energy, pressure, magnetic fields, and combinations thereof. | 05-29-2014 |
20140143522 | PREFETCHING BASED UPON RETURN ADDRESSES - An apparatus for processing data includes signature generation circuitry | 05-22-2014 |
20140142595 | MINIMAL ACCESS TOOL - A minimal access tool includes a frame arranged to be attached to an arm of a user, a tool shaft having a proximal end and a distal end, where the tool shaft proximal end is connected to the frame. The tool further includes an input joint having a first end connected to the frame and a second end arranged to receive user input, the input joint including a virtual center-of-rotation (VC) mechanism which provides a center of rotation that generally coincides with a wrist joint of the user. An output joint is connected to the tool shaft distal end, where the output joint is coupled to the input joint via a mechanical transmission connected therebetween to correlate motion of the input joint to motion of the output joint. | 05-22-2014 |
20140141459 | PENTRAXIN 3 ASSOCIATION WITH ASTHMA - The present invention relates to methods of utilizing pentraxin 3 as a marker for therapeutic efficacy in preclinical models of asthma. | 05-22-2014 |
20140140599 | ORDERED SUBSETS WITH MOMENTUM FOR X-RAY CT IMAGE RECONSTRUCTION - Methods, systems, and non-transitory computer readable media for image reconstruction are presented. Measured data corresponding to a subject is received. A preliminary image update in a particular iteration is determined based on one or more image variables computed using at least a subset of the measured data in the particular iteration. Additionally, at least one momentum term is determined based on the one or more image variables computed in the particular iteration and/or one or more further image variables computed in one or more iterations preceding the particular iteration. Further, a subsequent image update is determined using the preliminary image update and the momentum term. The preliminary image update and/or the subsequent image update are iteratively computed for a plurality of iterations until one or more termination criteria are satisfied. | 05-22-2014 |
20140138629 | OPTOELECTRONIC DEVICE FORMED WITH CONTROLLED VAPOR FLOW - An organic optoelectronic device (OED) includes a plurality of OED cells separated by a vapor flow barrier that extends away from a substrate surface. The vapor flow barrier partially defines an OED cell area and helps prevent stray organic material deflected away from the substrate surface during deposition from being deposited outside the cell area. An organic vapor jet (OVJ) print head can be used to deposit organic material along the vapor flow barrier and may include one or more features configured to capture some of the stray organic material. A method that includes use of vapor flow barriers and/or capturing stray organic material can facilitate high-density printing of OED cells such as OLEDs with sharply defined edges and without cross-contamination among adjacent cells. | 05-22-2014 |
20140134738 | METHODS FOR REGULATING NEURAL DIFFERENTIATION - Methods of producing populations of predominantly astrocytes, neurons or oligodendrocytes are provided. In addition, methods of treating mammals having astroglial tumors, oligodendrocyte tumors, or neuronal tumors are provided. | 05-15-2014 |
20140128327 | DENDRIMER CONJUGATES - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. | 05-08-2014 |
20140123976 | INTUBATION DEVICE - An intubation device having a main body portion defining a first longitudinal axis, a distal tip portion coupled to the main body portion and defining a second longitudinal axis, and a deflection system having a single drive member extending within at least the distal tip portion and coupled thereto. The deflection system is operable to exert a tensile force upon the distal tip portion to articulate the distal tip portion relative to the main body portion between a resting position and a positive incline position and a negative incline position. | 05-08-2014 |
20140118592 | CMOS IMAGE SENSORS WITH FEATURE EXTRACTION - A CMOS imaging sensor with ernbedded feature extraction capability operatable in different modes by a method that includes the steps of: (a) operating the CMOS imaging sensor in a motion-detecting mode at a first power level using circuitry on the imaging sensor that generates motion data based on received images detected by pixels in the pixel array; (b) switching the imaging sensor from the motion-detecting mode to a feature extraction mode in response to detecting motion; and (c) operating the imaging sensor in the feature extraction mode at a second power level that is higher than the first power level. | 05-01-2014 |
20140116331 | ORGANIC VAPOR JET PRINT HEAD WITH SOLDER JOINT - A solder joint may be used to attach components of an organic vapor jet printing device together with a fluid-tight seal that is capable of performance at high temperatures. The solder joint includes one or more metals that are deposited over opposing component surfaces, such as an inlet side of a nozzle plate and/or an outlet side of a mounting plate. The components are pressed together to form the solder joint. Two or more of the deposited metals may be capable of together forming a eutectic alloy, and the solder joint may be formed by heating the deposited metals to a temperature above the melting point of the eutectic alloy. A diffusion barrier layer and an adhesion layer may be included between the solder joint and each of the components. | 05-01-2014 |
20140112891 | AUTOLOGOUS HUMAN ADULT PLURIPOTENT VERY SMALL EMBRYONIC-LIKE (hVSEL) STEM CELL REGENERATION OF BONE AND CARTILAGE - The invention provides methods and compositions for the repair or regeneration of osteochondral tissue. The methods and compositions provide an effective amount of isolated differentiable human Very Small Embryonic Like Stem Cells (hVSELs) sufficient for regeneration or repair of an osteochondral tissue. The compositions can be administered directly to the tissue or administered systemically. | 04-24-2014 |
20140107510 | AUTOMATED ANALYSIS OF MULTI-LEAD ELECTROCARDIOGRAM DATA TO IDENTIFY THE EXIT SITES OF PHYSIOLOGICAL CONDITIONS - Techniques identify origins of ventricular arrhythmias (e.g., ventricular tachycardia or premature ventricular complexes) including exit sites or other sites using a single or multi-lead electrocardiogram (ECG) assembly. The ECG assembly is used to map an organ into a series of different three-dimensional (3D) regions. Pace maps or ventricular arrhythmia signals are used in form of ECG signals along with a supervised learning methods to pinpoint the potential origin of VT, i.e., exit sites, in the various regions. | 04-17-2014 |
20140106062 | METHOD OF MONITORING PHOTOACTIVE ORGANIC MOLECULES IN-SITU DURING GAS-PHASE DEPOSITION OF THE PHOTOACTIVE ORGANIC MOLECULES - A method for in-situ monitoring of gas-phase photoactive organic molecules in real time while depositing a film of the photoactive organic molecules on a substrate in a processing chamber for depositing the film includes irradiating the gas-phase photoactive organic molecules in the processing chamber with a radiation from a radiation source in-situ while depositing the film of the one or more organic materials and measuring the intensity of the resulting photoluminescence emission from the organic material. One or more processing parameters associated with the deposition process can be determined from the photoluminescence intensity data in real time providing useful feedback on the deposition process. | 04-17-2014 |
20140103581 | SYSTEMS AND METHODS FOR FABRICATING THREE-DIMENSIONAL OBJECTS - Systems and methods for fabricating three-dimensional objects are disclosed. The system includes an optical imaging system providing a light source; a photosensitive medium adapted to change states upon exposure to a portion of the light source from the optical imaging system; a control system for controlling movement of the optical imaging system, wherein the optical imaging system moves continuously above the photosensitive medium. The method includes moving a maskless optical imaging system providing the light beam in a continuous sequence; presenting the light beam on a portion of the photosensitive medium; lowering a plate upon which the photosensitive medium resides; and applying a new layer of the photosensitive medium. | 04-17-2014 |
20140102371 | COMPACT ORGANIC VAPOR JET PRINTING PRINT HEAD - A first device is provided. The first device includes a print head, and a first gas source hermetically sealed to the print head. The print head further includes a first layer further comprising a plurality of apertures, each aperture having a smallest dimension of 0.5 to 500 microns. A second layer is bonded to the first layer. The second layer includes a first via in fluid communication with the first gas source and at least one of the apertures. The second layer is made of an insulating material. | 04-17-2014 |
20140094702 | METHODS AND APPARATUSES FOR MEASURING TISSUE STIFFNESS CHANGES USING ULTRASOUND ELASTICITY IMAGING - A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area. | 04-03-2014 |
20140093962 | NON-ADHERENT CELL SUPPORT AND MANUFACTURING METHOD - A non-adherent cell support for use as a substrate in fluidic chambers used for cell culturing and assays. The non-adherent cell support allows for the formation of sphere cultures from single cells, which can better mimic primary tumor-like behavior in the study of cancer stem cells. The non-adherent cell support can allow for adhesive culturing and may include a hydrophobic substrate having a lower body and a raised support structure extending upwardly from an upper surface of the body. The support structure comprises one or more vertically extending support members that extend from a proximal portion at the upper surface of the body to a distal end spaced from the upper surface of the body. The support structure may be formed from a biocompatible material such as poly-2-hydroxyethyl methacrylate, polydimethylsiloxane, polymethyl methacrylate, polystyrene, or a polyethylene glycol diacrylate-based hydrogel. | 04-03-2014 |
20140093953 | NON-ADHERENT CELL SUPPORT AND MANUFACTURING METHOD - A non-adherent cell support for use as a substrate in fluidic chambers used for cell culturing and assays. The non-adherent cell support allows for the formation of sphere cultures from single cells, which can better mimic primary tumor-like behavior in the study of cancer stem cells. The non-adherent cell support can allow for adhesive culturing and may include a hydrophobic substrate having a lower body and a raised support structure extending upwardly from an upper surface of the body. The support structure comprises one or more vertically extending support members that extend from a proximal portion at the upper surface of the body to a distal end spaced from the upper surface of the body. The support structure may be formed from a biocompatible material such as poly-2-hydroxyethyl methacrylate, polydimethylsiloxane, polymethyl methacrylate, polystyrene, or a polyethylene glycol diacrylate-based hydrogel. | 04-03-2014 |
20140093537 | IMMUNOGENIC COMPOSITIONS COMPRISING NANOEMULSION AND METHODS OF ADMINISTERING THE SAME - The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of administering the same (e.g., via a heterologous prime/boost protocol (e.g., utilizing the same nanoemulsion in each the prime and boost administrations)) to induce immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. | 04-03-2014 |
20140081127 | Advanced Intraoperative Neural Targeting System and Method - A neural targeting system and method for deep brain stimulation procedures, or other types of brain surgeries requiring targeting, provides high spatial resolution and real-time targeting analysis to identify structural boundaries resulting in increased spatial accuracy. The system and method uses quantitative electrophysiology to update static brain images with an actual microelectrode location and trajectory in the brain to ensure correct placement of a later implanted stimulation probe. | 03-20-2014 |
20140076403 | DIPYRIN BASED MATERIALS FOR PHOTOVOLTAICS, COMPOUNDS CAPABLE OF UNDERGOING SYMMETRY BREAKING INTRAMOLECULAR CHARGE TRANSFER IN A POLARIZING MEDIUM AND ORGANIC PHOTOVOLTAIC DEVICES COMPRISING THE SAME - The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of making organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. The present disclosure also generally relates to chromophoric compounds that combine strong absorption of light at visible wavelengths with the ability to undergo symmetry-breaking intramolecular charge transfer (ICT), and their use for the generation of free carriers in organic photovoltaic cells (OPVs) and electric-field-stabilized geminate polaron pairs. The present disclosure also relates to the synthesis of such compounds, methods of manufacture, and applications in photovoltaic systems and organic lasers. | 03-20-2014 |
20140071180 | METHOD AND APPARATUS FOR SUPPRESSING BACKGROUND LIGHT IN TIME OF FLIGHT SENSOR - A background light suppression apparatus and method capable of suppressing influences of background light in a depth sensor includes measuring output signals of sub pixels for a sub integration time shorter than a frame integration time; and integrating differences between the output signals after the sub integration time. | 03-13-2014 |
20140070905 | WIDE RANGE CONTINUOUSLY TUNABLE CAPACITOR BANK - A wide range tunable capacitor bank is provided. The capacitor bank comprises a variable capacitor, the capacitance value of which is adjustable within a predetermined capacitance range defined by a minimum capacitance value and a maximum capacitance value. The capacitor bank further comprises one or more switched capacitors each electrically connected in circuit to the variable capacitor. The variable capacitor is configured to allow the capacitance value thereof to be adjusted within the predetermined capacitance range and the one or more switched capacitors are configured to be selectively actuated to permit continuous tuning of the capacitor bank over a second capacitance range that is greater than the predetermined capacitance range. Applications in which the capacitor bank may be implemented, and a method of fabricating an integrated system comprising a plurality of passive components, such as, for example, those of the capacitor bank and high quality factor inductors, are also provided. | 03-13-2014 |
20140064583 | Analytic Morphomics: High Speed Medical Image Automated Analysis Method - A computer-implemented method is provided for anatomically indexing a subject. The method includes: receiving image scan data representing a volume of a subject, where the image scan data is comprised of a plurality of image slices of the subject and includes at least a portion of a vertebral column of the subject; identifying the vertebral canal of the vertebral column of the subject in the image scan data; determining a plurality of markers for the vertebral column, where each marker is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a coordinate system, such that the plurality of markers define a vertebral level coordinate system; and storing each marker along with its location in a database. The markers can subsequently be used to reference other anatomical components of the subject across different image scans. | 03-06-2014 |
20140061594 | HIGH EFFICIENCY AND BRIGHTNESS FLUORESCENT ORGANIC LIGHT EMITTING DIODE BY TRIPLET-TRIPLET FUSION - A first device is provided. The first device further comprises an organic light emitting device. The organic light emitting device further comprises an anode, a cathode, and an emissive layer disposed between the anode and the cathode. The emissive layer may include an organic host compound and at least one organic emitting compound capable of fluorescent emission at room temperature. Various configurations are described for providing a range of current densities in which T-T fusion dominates over S-T annihilation, leading to very high efficiency fluorescent OLEDs. | 03-06-2014 |
20140057924 | BIVALENT INHIBITORS OF IAP PROTEINS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed. | 02-27-2014 |
20140057794 | LUNG CANCER SIGNATURE - The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to cancer markers as diagnostic markers and clinical targets for lung cancer. | 02-27-2014 |
20140056949 | Controlled Release Mucoadhesive Systems - Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described. | 02-27-2014 |
20140051601 | METABOLOMIC PROFILING OF CANCER - The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer. | 02-20-2014 |
20140039589 | METHOD FOR MANUFACTURING AN IMPLANTABLE ELECTRONIC DEVICE - A method of manufacturing an implantable electronic device, including: providing a silicon wafer; building a plurality of layers coupled to the wafer including an oxide layer coupled to the silicon wafer; a first reactive parylene layer coupled to the oxide layer, an electrode layer coupled to the first reactive parylene layer, and a second reactive parylene layer, coupled to the electrode layer, that chemically bonds to the first reactive polymer layer, and a second polymer layer coupled to the second reactive parylene layer; coating the plurality of layers with an encapsulation, and modifying the encapsulation and at least one of the plurality of layers to expose an electrode site in the electrode layer. | 02-06-2014 |
20140038947 | THERAPEUTIC APPLICATIONS OF PRO-APOPTOTIC BENZODIAZEPINES - Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of structures: | 02-06-2014 |
20140037644 | Prospective Identification and Characterization of Breast Cancer Stem Cells - The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(Dll4) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells. | 02-06-2014 |
20140034141 | RECONFIGURABLE MICROACTUATOR AND METHOD OF CONFIGURING SAME - A microactuator may be configured by activating a source of electromagnetic radiation to heat and melt a selected set of phase-change plugs embedded in a substrate of the microactuator, pressurizing a common pressure chamber adjacent to each of the plugs to deform the melted plugs, and deactivating the source of electromagnetic radiation to cool and solidify the melted plugs. | 02-06-2014 |
20140032431 | System and Method for Resolving Warrants - Systems and methods automatically resolve outstanding arrest warrants. Users may login to an automated system and answer a series of questions from an adaptive questionnaire module. Based on the user's answers, a bargained for deal may be selected from a payout matrix module and presented to the user. The user may have the option of accepting or rejecting the proposed deal, and if the user accepts the proposed deal, the deal and other relevant information may be sent to a government official for further processing if necessary. | 01-30-2014 |
20140030786 | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER - The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells. | 01-30-2014 |
20140030711 | METHODS AND BIOMARKERS FOR DETECTION OF LYMPHOMA - The present invention relates to methods and biomarkers for detection and characterization of lymphoma (e.g., splenic marginal zone lymphoma) in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples). | 01-30-2014 |
20140029104 | DISPLAY DEVICE HAVING PLASMONIC COLOR FILTERS AND PHOTOVOLTAIC CAPABILITIES - A plasmonic optical spectrum filtering device is provided that filters electromagnetic waves by optical resonance, for example, by selective conversion between the free-space waves and spatially confined modes in plasmonic nano-resonators. Frequency-selective transmission and reflection spectra are engineered and can be used as spectrum filters for display and imaging applications. A thin film stack color filter is further disclosed, which can be designed to either function as a transmission color filter with efficiency twice that of conventional colorant based color filter; or as a reflective color filter for display devices (e.g., used in an energy harvesting reflective display). In other variations, a novel reflective colored display is viewable under direct sunlight, and can simultaneously harvest both incident light and generate electrical power. Methods of making such plasmonic optical spectrum filtering devices are also provided. | 01-30-2014 |
20140017700 | SENSITIVE INTRACAVITY BIOSENSING PLATFORM AND METHODS FOR DETECTION THEREWITH - The present disclosure provides a method of detecting a target analyte, by binding the target analyte and a probe with at least one fluorophore to form a fluid composition. The fluid composition is excited within a laser cavity. The method comprises measuring a laser emission from the fluid composition based on an interaction between the target analyte and the probe. In certain aspects, the method provides hybridizing the target analyte and the probe, prior to the exciting. In certain variations, the methods comprise detecting a target analyte by measuring a laser emission from the fluid composition based on an interaction between the target analyte, where the interaction is probe energy transfer, intercalation, hybridization of the target analyte and the probe, or combinations thereof. The energy transfer can include fluorescence resonance energy transfer (FRET), FRET with a molecular-beacon, or cavity-assisted radiative energy transfer, by way of non-limiting example. | 01-16-2014 |
20140013178 | ERROR RECOVERY WITHIN INTEGRATED CIRCUIT - An integrated circuit includes one or more portions having error detection and error correction circuits and which is operated with operating parameters giving finite non-zero error rate as well as one or more portions formed and operated to provide a zero error rate. | 01-09-2014 |
20140011274 | ISOLATION AND USE OF SOLID TUMOR STEM CELLS - A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. | 01-09-2014 |
20140004539 | SYSTEMS AND METHODS FOR MULTIPLEX SOLUTION ASSAYS | 01-02-2014 |
20130345566 | LINEAR MAGNETIC DRIVE TRANSDUCER FOR ULTRASOUND IMAGING - An ultrasound imaging system uses a magnetic linear motor driven ultrasound scanner, with accurate track and hold operation and/or other motion feedback, to scan a two dimensional or three dimensional area of a sample. The scanner is implemented in a low-power and low-bandwidth handheld device and is connected with a remote image processing system that receives raw data and performs full ultrasound image analysis and creation, allowing the handheld to be used for scanning, pre-processing, and display. | 12-26-2013 |
20130338457 | METHOD AND APPARATUS FOR DETECTING DISEASES ASSOCIATED WITH THE EYE - Disease may be detected, monitored, etc. by detecting metabolic dysfunction in a patient's eyes. In one embodiment of an apparatus, an excitation light is generated by an excitation light source to induce autofluorescence in an ocular tissue (e.g., retinal tissue), wherein the excitation light excites flavoprotein autofluorescence (FA) and minimizes the excitation of non-flavoprotein autofluorescence. At least a single image representing the induced ocular tissue autofluorescence is captured. The at least single image is intensified to increase the signal strength of the ocular tissue autofluorescence. The at least single image is analyzed to generate an indicator of whether a patient has one or more of eye damage, a disease that causes eye damage, or to generate an indicator of the progression of a disease, an indicator of the effectiveness of a treatment, a personalized treatment for a subject, etc. | 12-19-2013 |
20130330389 | ULTRASOUND-TRIGGERABLE AGENTS FOR TISSUE ENGINEERING - The present invention is directed to compositions and methods for delivering a tissue scaffold comprising ultrasound-triggerable agents to an individual. | 12-12-2013 |
20130329920 | PIEZOELECTRIC MEMS MICROPHONE - A piezoelectric MEMS microphone comprising a multi-layer sensor that includes at least one piezoelectric layer between two electrode layers, with the sensor being dimensioned such that it provides a near maximized ratio of output energy to sensor area, as determined by an optimization parameter that accounts for input pressure, bandwidth, and characteristics of the piezoelectric and electrode materials. The sensor can be formed from single or stacked cantilevered beams separated from each other by a small gap, or can be a stress-relieved diaphragm that is formed by deposition onto a silicon substrate, with the diaphragm then being stress relieved by substantial detachment of the diaphragm from the substrate, and then followed by reattachment of the now stress relieved diaphragm. | 12-12-2013 |
20130329275 | OPTICAL DEVICES WITH SWITCHABLE PARTICLES - Optical display devices and methods of operating such devices are provided. The optical device includes a display component having a plurality of anisotropic multiphasic particles with at least two optically distinct phases. The plurality of anisotropic multiphasic particles is disposed in one or more regions of the display component that define an optic feature. Further, at least one of the phases of the anisotropic multiphasic particle comprises a material receptive to a force field, such as a magnetic material is receptive to an applied magnetic field. In this manner, the display component can reversibly exhibit a first optical state in the presence of the force field and thus is optionally switchable. | 12-12-2013 |
20130326646 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING NEUROLOGICAL CONDITIONS - The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NIPA-1 proteins. | 12-05-2013 |
20130319122 | LASER-BASED EDGE DETECTION - A system to detect an edge of an object includes an optical instrument configured to direct a laser beam toward the object, configured to receive a reflection of the laser beam based on whether the laser beam impacts the object, and configured to generate an intensity output indicative of an intensity of the reflection, a positioning system configured to position the object in a location relative to the optical instrument, the positioning system including a position sensor to provide a position output indicative of the location, and a processor configured to determine a position of the edge of the object based on the intensity output and the position output. | 12-05-2013 |
20130305990 | Apparatus and Method for Deposition for Organic Films - The invention provides apparatus and methods for organic continuum vapor deposition of organic materials on large area substrates. | 11-21-2013 |
20130305922 | GAS DEHUMIDIFICATION BY MICROPOROUS COORDINATION POLYMERS - A gas-dehumidification method can include passing a humid gas stream through a water-sorbing sorbent comprising a microporous coordination polymer or derivative thereof, wherein the sorbent sorbs water from the passing humid gas stream to produce a water-sorbed sorbent and a dehumidified gas stream. The method can further include passing a drying gas through the water-sorbed sorbent under conditions sufficient to desorb the water and to regenerate the water-sorbing sorbent. | 11-21-2013 |
20130293082 | THERMAL MANAGEMENT OF OLED DEVICES - An electrically powered light source can be constructed with an electroluminescent element operating essentially at room temperature while providing a useful amount of light. A thermal junction located between an OLED and a cover layer of an OLED device is configured to advantageously manage the steady-state temperature of the OLED. The thermal junction may be formed with a thermal resistance of 0.2 m | 11-07-2013 |
20130292573 | PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS AND METHOD FOR IMPROVING TOPOLOGICAL UNIFORMITY OF THE PHOTODIODE AND OTHER SENSOR STRUCTURES IN FLAT-PANEL X-RAY IMAGERS BASED ON THIN-FILM ELECTRONICS - A radiation sensor including a scintillation layer configured to emit photons upon interaction with ionizing radiation and a photodetector including in order a first electrode, a photosensitive layer, and a photon-transmissive second electrode disposed in proximity to the scintillation layer. The photosensitive layer is configured to generate electron-hole pairs upon interaction with a part of the photons. The radiation sensor includes pixel circuitry electrically connected to the first electrode and configured to measure an imaging signal indicative of the electron-hole pairs generated in the photosensitive layer and a planarization layer disposed on the pixel circuitry between the first electrode and the pixel circuitry such that the first electrode is above a plane including the pixel circuitry. A surface of at least one of the first electrode and the second electrode at least partially overlaps the pixel circuitry and has a surface inflection above features of the pixel circuitry. The surface inflection has a radius of curvature greater than one half micron. | 11-07-2013 |
20130292546 | OPTICALLY-INDUCED CHARGE SEPARATION AND INDUCED MAGNESTISM IN DIELECTRICS FOR OPTICAL ENERGY CONVERSION AND INTENSE MAGNETIC FIELD GENERATION - Schemes are described to produce quasi-static charge separation, Terahertz radiation, and programmable magnetic field generation using linearly-polarized light in unbiased, transparent insulators. The methods exploit a recently-observed magneto-electric optical nonlinearity that produces intense magnetization in undoped, homogeneous dielectrics. Analysis reveals that strong magnetic effects can be induced at modest optical intensities even with incoherent light. Consequently, efficient solar power conversion is feasible without the semiconductor processing or electron-hole pair generation that is required in conventional photovoltaic cells. Additionally, conditions and techniques are described to generate intense THz radiation in unbiased substrates and large magnetic fields orientated transverse to the direction of propagation of light, without the need for any external permanent magnetic or electromagnetic apparatus. | 11-07-2013 |
20130290679 | NEXT BRANCH TABLE FOR USE WITH A BRANCH PREDICTOR - A data processing system | 10-31-2013 |
20130283884 | HIGH RESOLUTION PIPETTE - A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device. | 10-31-2013 |
20130283404 | EPIGENETICS IN AUTOIMMUNITY - Provided herein are compositions and methods for the diagnosis, monitoring, treatment, and/or prevention of autoimmune disease (e.g., lupus) based on a causal connection with various epigenetic markers (e.g., chromosome demethylation, overexpression of lupus markers, nitration of PKCδ in response to oxidative stress, etc.). | 10-24-2013 |
20130283101 | Trace-Driven Verification of Multithreaded Programs Using SMT-Based Analysis - The method of testing for presence of a bug a multithreaded computer program under verification combines the efficiency of testing with the reasoning power of satisfiability modulo theory (SMT) solvers for the verification of multithreaded programs under a user specified test vector. The method performs dynamic executions to obtain both under- and over-approximations of the program, represented as quantifier-free first order logic formulas. The formulas are then analyzed by an SMT solver which implicitly considers all possible thread interleavings. The symbolic analysis may return the following results: (1) it reports a real bug, (2) it proves that the program has no bug under the given input, or (3) it remains inconclusive because the analysis is based on abstractions. In the last case, a refinement procedure is presented that uses symbolic analysis to guide further executions. | 10-24-2013 |
20130276543 | VIRTUAL NONCONTACT EXCITATION - An excitation system includes a pair of piezoelectric elements configured to apply respective excitation forces to a test structure, a clamp including an adjustable arm, the adjustable arm being configured to capture the test structure between the pair of piezoelectric elements, a controller coupled to the pair of piezoelectric elements and configured to generate a respective excitation control signal for each piezoelectric element, each excitation control signal being configured such that the respective excitation forces are matched to one another, and a pair of sensor film structures to generate respective output signals indicative of the excitation forces applied to the test structure, each sensor film structure being disposed between a respective one of the pair of piezoelectric elements and the test structure. | 10-24-2013 |
20130273113 | IMMUNOGENIC APOPTOSIS INDUCING COMPOSITIONS AND METHODS OF USE THEREOF - The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., immunologic cell death/apoptosis (e.g., for the induction of innate and/or adaptive immune responses)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., for infectious disease, cancer, autoimmunity, and/or tissue injury (e.g., via alteration of host immune responses))) and research applications. | 10-17-2013 |
20130267443 | ncRNA AND USES THEREOF - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer. | 10-10-2013 |
20130266937 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 10-10-2013 |
20130261537 | NITRIC OXIDE DELIVERY DEVICES - A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode. | 10-03-2013 |
20130261110 | NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like. | 10-03-2013 |
20130261026 | LINKERS AND CO-COUPLING AGENTS FOR OPTIMIZATION OF OLIGONUCLEOTIDE SYNTHESIS AND PURIFICATION ON SOLID SUPPORTS - A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications. | 10-03-2013 |
20130261022 | METABOLOMIC PROFILING OF PROSTATE CANCER - The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer). | 10-03-2013 |
20130260113 | HYBRID NANOSTRUCTURE ARRAY - A hybrid nanostructure array having a substrate and two types of nanostructures, including a set of first nanostructures extending from the substrate and a set of second nanostructures interspersed among the first nanostructures. The first and second nanostructures comprise structures having nanoscale proportions in two dimensions and being elongate in the third dimension. For example, the nanostructures can be nanotubes, nanowires, nanorods, nanocolumns, and/or nanofibers. Also disclosed is a hybrid nanoparticle array using two different types of nanoparticles that have all three dimensions in the nanoscale. The two types of nanostructures or nanoparticles can vary in composition, shape, or size. | 10-03-2013 |
20130259079 | GaN-Based Quantum Dot Visible Laser - A III-nitride based quantum dot (QD) laser is formed of InGaN/GaN quantum dots and capable emitting at a single wavelength within the visible region, including the violet wavelength region (400-440 nm), the blue wavelength region (440-490 nm), the green wavelength region (490-570 nm), the yellow wavelength region (570-590 nm), the orange wavelength region (590-620 nm), and the red wavelength region (620-700 nm), with varying composition as described. | 10-03-2013 |
20130253348 | REAL TIME CLINICAL DECISION SUPPORT SYSTEM HAVING LINKED REFERENCES - A clinical decision support system for patient treatment having a monitoring device operably coupled to a patient. The monitoring device outputs a monitoring signal in response to a measured parameter of the patient. A controller receives the monitoring signal and outputs a display signal. The controller further compiles clinical documentation relating to the patient based on the monitoring signal and outputs a documentation signal related thereto. A display device then receives the display signal and the documentation signal and displays the same in connection with various indicia thereby displaying both the monitored signal and associated clinical documentation. | 09-26-2013 |
20130245485 | SYSTEM AND METHOD TO ASSESS CAUSAL SIGNALING IN THE BRAIN DURING STATES OF CONSCIOUSNESS - A system and method for assessing causal signaling in the brain during states of consciousness are described. More specifically, a system and method for determining a directed functional connectivity in the brain wherein neurophysiologic correlates are analyzed with respect to feedback and/or feedforward activities to determine a directional feedback connectivity and/or a directional feedforward connectivity associated with a level of consciousness in the brain. | 09-19-2013 |
20130245481 | REAL TIME CLINICAL DECISION SUPPORT SYSTEM HAVING MEDICAL SYSTEMS AS DISPLAY ELEMENTS - A clinical decision support system for patient treatment that incorporates patient data to display information in readily identifiable icons for vital organs and medical systems, and in a useable, real-time, updated fashion that extracts data from the medical history, the current medical management, the current physiologic monitors, and associated medical systems to produce warnings and alerts to enable caregivers to be made aware of physiologic systems at risk. These data are not only presented, but also use real-time queries and calculations to enable caregivers to have the types of data that would traditionally assist them in patient care but only be available by reviewing the medical literature and/or doing retrospective individual calculations while providing patient care. | 09-19-2013 |
20130243874 | NANOPARTICLES COATED WITH AMPHIPHILIC BLOCK COPOLYMERS - The present provides amphiphilic block copolymer coated surfaces (e.g., nanoparticles, medical devices, etc.) and methods of preparing such surfaces. In certain embodiments, the present invention provides amphiphilic block copolymer coated single dispersed nanoparticles, which are stable in buffer (e.g., PBS) and have neutral but functionable surfaces, and methods of preparing the same. | 09-19-2013 |
20130240850 | ULTRA-HIGH EFFICIENCY (125%) PHOSPHORESCENT ORGANIC LIGHT EMITTING DIODES USING SINGLET FISSION - An organic light emitting device (OLED) is provided. The OLED includes, an anode; a cathode; and an emissive layer disposed between the anode and the cathode. The emissive layer includes a singlet fission sensitizer and a triplet emitter. The singlet energy of the singlet fission sensitizer is equal to or greater than twice the triplet energy of the singlet fission sensitizer. The triplet energy of the triplet emitter is less than the triplet energy of the singlet fission sensitizer. | 09-19-2013 |
20130240840 | METAL OXIDE CHARGE TRANSPORT MATERIAL DOPED WITH ORGANIC MOLECULES - Doping metal oxide charge transport material with an organic molecule lowers electrical resistance while maintaining transparency and thus is optimal for use as charge transport materials in various organic optoelectronic devices such as organic photovoltaic devices and organic light emitting devices. | 09-19-2013 |
20130237411 | Novel Strategies, Linkers and Coordination Polymers for High-Performance Sorbents - A linking ligand compound includes three bidentate chemical moieties distributed about a central chemical moiety. Another linking ligand compound includes a bidentate linking ligand and a monodentate chemical moiety. Coordination polymers include a plurality of metal clusters linked together by residues of the linking ligand compounds. | 09-12-2013 |
20130237001 | METHODS OF PREPARING FLEXIBLE PHOTOVOLTAIC DEVICES USING EPITAXIAL LIFTOFF, AND PRESERVING THE INTEGRITY OF GROWTH SUBSTRATES USED IN EPITAXIAL GROWTH - There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse. | 09-12-2013 |
20130233244 | COMPACT ORGANIC VAPOR JET PRINTING PRINT HEAD - A first device is provided. The first device includes a print head, and a first gas source hermetically sealed to the print head. The print head further includes a first layer further comprising a plurality of apertures, each aperture having a smallest dimension of 0.5 to 500 microns. A second layer is bonded to the first layer. The second layer includes a first via in fluid communication with the first gas source and at least one of the apertures. The second layer is made of an insulating material. | 09-12-2013 |
20130225438 | SOLUTION MICROARRAYS AND USES THEREOF - The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention further relates to systems and methods for performing assays within the solution microarrays (e.g., diagnostic assays). | 08-29-2013 |
20130213811 | MICROSCALE WESTERN BLOT - Systems and methods are provided for integrating the electrophoresis and blotting of samples. A capillary electrophoresis and blotting system allows concomitant electrophoretic separation and blotting to provide a rapid and simplified process. A microfluidic electrophoresis and blotting system provides electrophoretic separation in a microfluidic channel followed by electroblotting from the microfluidic channel to also provide a rapid and simplified process. These systems and methods can be used to assay smaller amounts of sample in less time than conventional processes, including conventional Western blotting techniques. | 08-22-2013 |