THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Patent applications |
Patent application number | Title | Published |
20160142039 | CONTOUR-MODE PIEZOELECTRIC MICROMECHANICAL RESONATORS - A contour mode micromechanical piezoelectric resonator. The resonator has a bottom electrode; a top electrode; and a piezoelectric layer disposed between the bottom electrode and the top electrode. The piezoelectric resonator has a planar surface with a cantilevered periphery, dimensioned to undergo in-plane lateral displacement at the periphery. The resonator also includes means for applying an alternating electric field across the thickness of the piezoelectric resonator. The electric field is configured to cause the resonator to have a contour mode in-plane lateral displacement that is substantially in the plane of the planar surface of the resonator, wherein the fundamental frequency for the displacement of the piezoelectric resonator is set in part lithographically by the planar dimension of the bottom electrode, the top electrode or the piezoelectric layer. | 05-19-2016 |
20160140729 | VISUAL-INERTIAL SENSOR FUSION FOR NAVIGATION, LOCALIZATION, MAPPING, AND 3D RECONSTRUCTION - A new method for improving the robustness of visual-inertial integration systems (VINS) based on derivation of optimal discriminants for outlier rejection, and the consequent approximations, that are both conceptually and empirically superior to other outlier detection schemes used in this context. It should be appreciated that VINS is central to a number of application areas including augmented reality (AR), virtual reality (VR), robotics, autonomous vehicles, autonomous flying robots, and so forth and their related hardware including mobile phones, such as for use in indoor localization (in GPS-denied areas), and the like. | 05-19-2016 |
20160140316 | SYSTEMS AND METHODS FOR AUTOMATICALLY EVALUATING MEDICAL PATIENT SYMPTOMS AND PROVIDING TAILORED PRESCRIPTIONS - The present disclosure is generally related to automatically evaluating medical patient symptoms and, more specifically, to systems and methods for providing tailored prescriptions, multi-dimensional patient matching and symptom monitoring. In particular, a medical patient completes a questionnaire, responses to the questionnaire are correlated with information obtained from a medical knowledge resource and an integrated symptoms summary is generated based on the responses to the questionnaire and the information obtained from the medical knowledge resource. A tailored prescription is provided to the patient based on the integrated symptoms summary and physician consultation (if applicable), patients are compared to other patients according to questionnaire responses so that they can connect with each other if they chose, and patients are able to monitor symptoms over time so that they can gain insight into whether treatments are working. | 05-19-2016 |
20160140303 | VALUE-BASED HEALTH CARE MANAGEMENT SYSTEMS AND METHODS - A system and method are disclosed for management of patient care and research using a combination of value-based methodology and translational research methodology. The system includes software to generate a single outcome measurement, or “Value-Quotient (VQ)” expressing a delivered health value and the associated costs. The software may also include a user interface to generate and manage coordinated care pathways (i.e. tight control scenarios) aimed at complication prevention and disease control. The software also may include functionality for direct task differentiation for provider teams, shifting work load from physicians to trained nurses and administration. | 05-19-2016 |
20160139015 | METHOD AND DEVICE FOR ISOLATING CELLS FROM HETEROGENEOUS SOLUTION USING MICROFLUIDIC TRAPPING VORTICES - A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region. | 05-19-2016 |
20160138114 | Biomarkers of Response to Inhibition of Poly-ADP Ribose Polymerase (PARP) in Cancer - Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor. | 05-19-2016 |
20160138051 | ACETOLACTATE SYNTHASE HAVING 2-KETOISOVALERATE DECARBOXYLASE ACTIVITY AND USES THEREOF - Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol, and 2-phenylethanol from a suitable substrate and a recombinant acetolactate synthase having both synthase and decarboxylase activity. | 05-19-2016 |
20160136310 | SYSTEMS, COMPOSITIONS, AND METHODS FOR LOCAL IMAGING AND TREATMENT OF PAIN - Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor. | 05-19-2016 |
20160134460 | DIFFERENTIAL CURRENT MODE LOW LATENCY MODULATION AND DEMODULATION FOR CHIP-TO-CHIP CONNECTION - A chip-to-chip communications circuit which is particularly well-suited for short range communication (less than a few inches) from one integrated circuit (chip) to another is presented. The circuits preferably utilize multi-frequency quadrature amplitude modulation (QAM) mechanisms for converting digital data bits from a parallel form into a serial analog stream for communication over a chip I/O connection. Differential current mode modulation in the transmitter, and demodulation in the receiver, are utilized which reduce latency and power-consumption while increasing manufacturing yields and resilience to process variations. | 05-12-2016 |
20160133790 | Textured phosphor conversion layer light emitting diode - This invention is related to LED Light Extraction for optoelectronic applications. More particularly the invention relates to (Al, Ga, In)N combined with optimized optics and phosphor layer for highly efficient (Al, Ga, In)N based light emitting diodes applications, and its fabrication method. A further extension is the general combination of a shaped high refractive index light extraction material combined with a shaped optical element. | 05-12-2016 |
20160132714 | FIRE URGENCY ESTIMATOR IN GEOSYNCHRONOUS ORBIT (FUEGO) - A fire detector is disclosed that successively images a particular area from geosynchronous Earth orbit satellite to attain very good signal-to-noise ratios against Poisson fluctuations within one second. Differences between such images allow for the automatic detection of small fires greater than 12 square meters. Imaging typically takes place in transparent bands of the infrared spectrum, thereby rendering smoke from the fire and light clouds somewhat transparent. Several algorithms are disclosed that can help reduce false fire alarms, and their efficiencies are shown. Early fire detection and response would be of great value in the United States and other nations, as wild land fires destroy property and lives and contribute around five percent of the US global carbon dioxide contribution. Such apparatus would incorporate modern imaging detectors, software, and algorithms able to detect heat from early and small fires, and yield detection times on a scale of minutes. | 05-12-2016 |
20160131391 | ELECTROACTIVE SMART HVAC VENT REGISTER - An electroactive register is shown configured to modulate the incoming airflow in an HVAC duct to form two localized airflows: a first a high-speed airflow to form a conical air curtain surrounding an occupant and limiting air exchange between inside air and air outside of the air curtain, and a second a low-speed airflow (also referred to as center air) inside the air curtain to cool or heat the occupant comfortably. The temperature gradient between inside and outside of the air curtain enables expansion of set points of HVAC. The electroactive register is also able to improve personal comfort as the center air F | 05-12-2016 |
20160130295 | MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM - A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module. | 05-12-2016 |
20160129415 | MULTIPLEX CHEMOTYPING MICROARRAY (MCM) SYSTEM AND METHODS - A Multiplex Chemotyping Microarray (MCM) system and methods are herein described. The MCM system and methods enable rapid chemical analyses of heterogeneous mixtures, by combining high-throughput micro-contact printing technology with high-fidelity (mass) vibrational spectroscopy. The MCM enables an error-free deposition and detection of multiple chemicals in a heterogeneous liquid sample at a throughput of more than two orders of magnitude beyond existing methods. | 05-12-2016 |
20160126535 | MITIGATING THERMAL RUNAWAY IN LITHIUM ION BATTERIES USING DAMAGE-INITIATING MATERIALS OR DEVICES - A method of manufacturing a battery includes introducing a first material to the battery, providing an anode, a cathode and a separator of the battery; and assembling the anode, the separator and the cathode. The first material is configured and arranged to increase the internal impedance of the battery upon mechanical or thermal loading. | 05-05-2016 |
20160123964 | METHODS FOR STRATIFYING NON-RESPONDERS TO THERAPIES THAT BLOCK PD1/PDL1 AXIS - A method of analyzing a biological sample from a subject that has a tumor or cancer, comprising: determining, for target cells having a phenotype of interest spatial resolution of the target cells, density of the spatially resolved target cells in the sample; and proximity between spatially resolved target cells of interest in the sample; and determining an overall score based at least in part on the preceding parameters. A method for identifying a patient as a responder to single agent anti-PD-1 or anti-PD-L1 therapy is provided. Similar methods are provided for detecting adaptive immune resistance, the presence of cancer in a patient sample, determining efficacy of cancer therapy, and determining response to and monitoring the efficacy of cancer therapy. | 05-05-2016 |
20160116357 | DROPLET-BASED CAPACITIVE PRESSURE SENSOR - A pressure sensing apparatus which utilizes an electrolytic droplet retained between a first and second sensing electrode within a housing. Contact between the electrolyte droplet and the electrodes form electric double layers (EDL) having interfacial EDL capacitance proportional to interface contact area which varies in response to mechanical pressure applied to deform exterior portions of the housing. The electrolyte contains a sufficient percentage of glycerol to prevent evaporative effects. Preferably, the sensing electrodes are modified with depressions, hydrophilic and/or hydrophobic portions to increase central anchoring of the electrolyte droplet within the housing. The inventive pressure sensor provides high sensitivity and resolution which is beneficial to numerous applications, and is particularly well-suited for medical sensing applications. | 04-28-2016 |
20160115500 | MODIFIED PYR/PYL RECEPTORS ACTIVATED BY LIGANDS - Modified PYR/PYL receptors activated by orthogonal ligands are provided. | 04-28-2016 |
20160115436 | DIGITAL MICROFLUIDIC PLATFORM FOR CREATING, MAINTAINING AND ANALYZING 3-DIMENSIONAL CELL SPHEROIDS - The invention provides a microfluidic system for forming and/or analyzing multi-cellular spheroids in a hanging drop cell culture. Embodiments of the invention include microfluidic (DμF) systems capable of creating and supporting hanging droplets of cell culture media for the purpose of initiating and maintaining the growth of three-dimensional, multi-cellular spheroids. The microfluidic systems disclosed herein are compatible with numerous analysis modalities including microscopy, mass spectrometry, and fluorescence spectroscopy. | 04-28-2016 |
20160115143 | METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS - The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to produce the fuels, gasoline additives, and/or lubricants, and precursors thereof may be derived from biomass. The fuels, gasoline additives, and/or lubricants, and precursors thereof may be produced by a combination of intermolecular and/or intramolecular aldol condensation reactions, Guerbet reactions, hydrogenation reactions, and/or oligomerization reactions. | 04-28-2016 |
20160114189 | SYSTEM AND METHOD FOR DOSE VERIFICATION AND GAMMA RAY IMAGING IN ION BEAM THERAPY - This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive detector configured to detect gamma rays generated by an ion beam interacting with a target. The collimator is positioned between the target and the position sensitive detector. The collimator includes a plurality of knife-edge slits, with a first knife-edge slit intersecting with a second knife-edge slit. | 04-28-2016 |
20160113941 | METHODS AND SYSTEMS OF TREATING WOUNDS - The invention generally relates to methods for treating and/or reducing the severity of a wound in a subject. Provided are wound therapies combining low level light therapy (LLLT) and a nitric oxide (NO) donor to treat and/or reduce the severity of the wound. The LLLT and NO donor may be administered concurrently or sequentially. Also provided are wound treatment systems and kits including a light source and a NO donor, which are administered to a wounded subject. Further provided are pharmaceutical compositions that comprise a NO donor and are formulated to be administered in conjunction with LLLT. | 04-28-2016 |
20160113887 | HALOGENATED ETHER COMPOUNDS AND METHODS OF INDUCING ANESTHESIA - A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers. | 04-28-2016 |
20160111721 | VOLTAGE-RESPONSIVE COATING FOR LITHIUM-SULFUR BATTERY - A sulfur-containing electrode with a surface layer comprising voltage responsive material. The electrode is used in a lithium-sulfur or silicon-sulfur battery. | 04-21-2016 |
20160111072 | MULTIFERROIC TRANSDUCER FOR AUDIO APPLICATIONS - A multiferroic transducer for an electrical stringed-instrument pickup comprising an upper layer and lower layer of magnetostrictive material and a middle layer of piezoelectric or ferroelectric material disposed between the upper layer and lower layer. | 04-21-2016 |
20160109258 | CONTINUOUS MODE REVERSAL FOR REJECTING DRIFT IN GYROSCOPES - A vibratory gyroscope system is described which utilizes a mechanical resonator having a first mode of vibration and an associated first natural frequency, and a second mode of vibration having an associated second natural frequency. The angular rate of motion input couples energy between the first and second modes of vibration. The gyroscope has driver circuits, sensors and actuators for the first and second modes. The invention utilizes a bias error shifting method which provides for shifting the bias error away from DC to a higher frequency, where it can be removed by low pass filtering. As a result of the inventive method, gyroscope systems can be produced with significantly lower bias error. | 04-21-2016 |
20160108883 | CARPET OF WAVE ENERGY CONVERSION (CWEC) - A carpet of wave energy conversion (CWEC) device mechanically couples an absorber carpet to one or more energy converters, thereby allowing for wave energy extraction from passing waves. The absorber carpet may be flexible material of a composite material that has a low elastic modulus in a longitudinal direction (to allow for stretching), and a relatively higher elastic modulus in a transverse direction (to better couple energy from wave to converters). Such designs have minimal wave reflections and high efficiencies within a relatively short extent of deployment. The resultant converted useful energy is available as either: 1) mechanical power including direct desalinization or electrical production; or 2) hydraulic power for a number of applications (including hydraulically powered motors supplying power to powered devices including generators), or pumping of the wave medium under pressure to an alternate location for irrigation or energy storage. | 04-21-2016 |
20160108364 | PLURIPOTENT HUMAN ADIPOSE ADULT STEM CELLS: ISOLATION, CHARACTERIZATION AND CLINICAL IMPLICATIONS - Methods for the efficient isolation and use of pluripotent adipose-derived stem cells (PASCs) are provided. In certain embodiments the methods involve providing an adipose tissue sample from which the stromal vascular fraction is co-cultured with the adipocyte fraction. PASCs can be isolated with a high degree of purification without requiring an additional cell enrichment process (e.g. cell sorting). PASCs and their conditioned media can be used for tissue regeneration within hours of harvesting the adipose tissue, and without requiring cell expansion. PASCs can grow as floating individual cells, as clusters of cells, or attached to surface(s) of the culture vessel. PASCs do not produce teratomas in vivo, nor do they induce immunorejection upon transplantation, and they achieve a high efficiency in grafting. The cells and compositions can be used for cell therapy and to screen new drugs. | 04-21-2016 |
20160108007 | SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS - The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs. | 04-21-2016 |
20160107951 | DIGITAL MICROFLUIDIC PLATFORM FOR RADIOCHEMISTRY - Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing | 04-21-2016 |
20160107934 | INORGANIC ADMIXTURES FOR MITIGATING AGAINST CONVERSION PHENOMENA IN HIGH-ALUMINA CEMENTS - A manufacturing process of a cement product includes: (1) incorporating at least one additive into a high-alumina cement composition, wherein the at least one additive is selected from nitrate-containing salts, nitrite-containing salts, carbonate-containing salts, sulfate-containing salts, chloride-containing salts, and hydroxide-containing salts; and (2) curing the high-alumina cement composition to form the cement product. | 04-21-2016 |
20160106331 | FRACTAL INDEX ANALYSIS OF HUMAN ELECTROENCEPHALOGRAM SIGNALS - A system and method for Multifractal-Detrended Fluctuation Analysis (MF-DFA) on digitized Human EEG signals is presented. A list of Hurst exponents, or Hurst exponent spectrum (“h” values) are generated, and multifractal singularity spectrum indices (“D(h)” values) produce a graph that approximates an inverted parabola. The output multifractal DFA spectrum is able to represent key features of the internal neuronal dynamics for the cortical neurons underlying the scalp-placed electrode which records the signals. | 04-21-2016 |
20160105213 | METHODS FOR CANCELLATION OF RADIO INTERFERENCE IN WIRELESS COMMUNICATION SYSTEMS - A full duplex radio includes self-interference cancellation circuitry for reducing self-interference. The self-interference cancellation circuitry may receive analog radio frequency signals that are to be transmitted by an antenna, and downconvert and digitize the signals to provide a digital baseband signal for processing, for example by an adaptive filter. The filtered signal may be Cconverted to an analog signal and applied in an analog portion of a receive chain of a receiver of the full duplex radio. Preferably the analog signal is applied in the receive chain after low noise amplification of received signals of interest. | 04-14-2016 |
20160102361 | NEUROTENSIN-INDUCED TUMOR FORMATION IS REGULATED BY MICRO RNA 133A-AFTIPHILIN-DEPENDENT RECEPTOR RECYCLING - This application discloses methods of treating, preventing, and diagnosing colorectal cancer and IBD in a subject comprising administering an effective dose of antisense miR-133α or AFTPH to the subject or detecting expression levels of miR-133α and AFTPH. | 04-14-2016 |
20160101418 | METHOD AND SYSTEM FOR ULTRA-HIGH DYNAMIC RANGE NUCLEIC ACID QUANTIFICATION - A method of quantifying nucleic acids in a sample includes generating a plurality of droplets in oil within a microfluidic device, wherein at least some of the droplets comprise a nucleic acid, amplification reagents, and a fluorescent probe or dyes contained therein. The droplets are delivered to a collection chamber to form an array of droplets. The droplets are subject to thermal cycling within the collection chamber a plurality of times to perform nucleic acid amplification within the droplets. The array of droplets is imaged during the plurality of thermal cycles as well as at a thermal cycle endpoint. An initial concentration of nucleic acid in the sample is calculated based on at least one of: a ratio of aqueous phase droplets exhibiting fluorescence within the array at the thermal cycle endpoint or a cycle threshold (Ct) of one or more aqueous phase droplets within the array. | 04-14-2016 |
20160101098 | SMALL MOLECULE ACTIVATORS OF NRF2 PATHWAY - This disclosure relates to compounds that act as activators of the NRF2/KEAP1/ARE pathway. Specifically, the compounds provided herein can act as high affinity reversible bindings for the NRF2 inhibitor, KEAP1. In some cases, NRF2/KEAP1/ARE pathway activation compounds are capable of repressing expression of inflammatory markers and/or reducing levels of TNFa to provide neuroprotective anti-inflammatory effects in the CNS. Such compounds are useful in the treatment of a variety of diseases including Huntington's disease, Parkinson's disease, Alzheimer's disease, inflammation, and cancer. | 04-14-2016 |
20160099035 | VOLTAGE-CONTROLLED MAGNETIC ANISOTROPY (VCMA) SWITCH AND MAGNETO-ELECTRIC MEMORY (MERAM) - Voltage controlled magnetic tunnel junctions and memory devices are described which provide efficient high speed switching of non-volatile magnetic devices at high cell densities. Implementations are described which provide a wide range of voltage control alternatives with in-plane and perpendicular magnetization, bidirectionally switched magnetization, and control of domain wall dynamics. | 04-07-2016 |
20160098630 | NEUROMORPHIC CIRCUIT THAT FACILITATES INFORMATION ROUTING AND PROCESSING - The disclosed embodiments relate to a system that selectively propagates information through a neuromorphic circuit comprising a set of interconnected neurons. During operation, a neuron in the set of neurons receives information-carrying current pulses from one or more upstream information-carrying neurons, wherein the information-carrying current pulses are insufficient to cause the neuron to generate output current pulses. The neuron also receives selectively generated gating current pulses from one or more gating neurons, wherein the gating current pulses cause a neural voltage of the neuron to approach a firing threshold. In this way, concurrently received information-carrying current pulses combine with the gating current pulses to cause the neural voltage to exceed the firing threshold, which causes the neuron to generate output current pulses that propagate to downstream neurons. | 04-07-2016 |
20160097235 | Insulated Window Frame System - The present invention provides for a window frame comprising a rigid framework cross-section comprising a truss structure. | 04-07-2016 |
20160087823 | NON-RECIPROCAL COMPONENTS WITH BALANCED DISTRIBUTEDLY MODULATED CAPACITORS (DMC) - A non-reciprocal radio frequency transceiver front end utilizing multiple time-varying transmission lines (TVTLs) implemented using distributed modulated capacitors (DMC) to exploit time-varying properties of transmission line structures to isolate the transmit and receive signals. The TVTLs are coupled at an input side to an antenna and ground through a first 90 degree coupler, and the outputs of the TVTLs are coupled through a second 90 degree coupler for connection to a receiver and transmit circuit, respectively. The apparatus allows simultaneously operating a transmitter and receiver sharing a single antenna (or single antenna array). | 03-24-2016 |
20160085854 | Dynamic Natural Language Conversation - Technologies are described herein for providing dynamic natural language interactions between a user and a computing device. In one aspect, a computing device managing a conversation with a user is enhanced with the identification and management of one or more topics. Using techniques described herein, the computing device can focus on one or more topics, shift between topics and/or introduce new topics. Techniques disclosed herein may also manage and process interruptions that may be introduced during a conversation. Dynamic access of contextual information may assist in the generation of contextually-relevant statements, and the contextual information may be used to balance priorities between various topics. Each topic may also have an associated decay rate so that the lifespan of individual topics may track realistic scenarios. In addition, the priorities of individual topics may be dynamically adjusted so topics may track events created by a user and a computing device. | 03-24-2016 |
20160085025 | WAVEGUIDE ARRANGEMENTS BASED ON ADIABATIC ELIMINATION - This disclosure provides systems, methods, and apparatus related to nanophotonics. In one aspect, an arrangement of waveguides includes a substrate and three waveguides. Each of the three waveguides may be a linear waveguide. A second waveguide is positioned between a first waveguide and a third waveguide. The dimensions and positions of the first, the second, and the third waveguides are specified to substantially eliminate coupling between the first waveguide and the third waveguide over a distance of about 1 millimeter to 2 millimeters along lengths of the first waveguide, the second waveguide, and the third waveguide. | 03-24-2016 |
20160084889 | SYSTEM AND METHOD FOR STABILITY MONITORING, ANALYSIS AND CONTROL OF ELECTRIC POWER SYSTEMS - A system and method for stability monitoring, analysis, and control of energy systems, such as electric power systems, is provided. Specifically, the system and method described herein use a Koopman mode analysis to represent the operation of individual components in an energy system and/or to determine and rank a level of stability of the individual components in the energy system. The system and method described herein also use a Koopman mode analysis to determine optimal and/or safe times to release energy stored in storage systems. | 03-24-2016 |
20160083751 | METHOD FOR PRODUCING ALDEHYDE FROM CO2 - The invention provides recombinant microorganisms capable of producing isobutyraldehyde using CO | 03-24-2016 |
20160081956 | GABA AGONISTS IN THE TREATMENT OF DISORDERS ASSOCIATED WITH METABOLIC SYNDROME AND GABA COMBINATIONS IN TREATMENT OR PROPHYLAXIS OF TYPE I DIABETES - In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the methods involve administering to a subject in need thereof, a GABA receptor agonist, in an amount sufficient to ameliorate said one or more symptoms. In certain embodiments methods are provided for the prophylaxis or treatment of type I diabetes and related pathologies that involve the use of GABA or GABA agonists in combination with certain other compounds (e.g., one more antigens (e.g., GAD) that have a therapeutic effect in type I diabetes and/or an anti-CD3 antibody, an anti-CD20 antibody, exendin-4, and/or or a pro-insulin therapeutic). | 03-24-2016 |
20160079499 | OPTICAL DESIGNS FOR HIGH-EFFICACY WHITE-LIGHT EMITTING DIODES - A method for increasing the luminous efficacy of a white light emitting diode (WLED), comprising introducing optically functional interfaces between an LED die and a phosphor, and between the phosphor and an outer medium, wherein at least one of the interfaces between the phosphor and the LED die provides a reflectance for light emitted by the phosphor away from the outer medium and a transmittance for light emitted by the LED die. Thus, a WLED may comprise a first material which surrounds an LED die, a phosphor layer, and at least one additional layer or material which is transparent for direct LED emission and reflective for the phosphor emission, placed between the phosphor layer and the first material which surrounds the LED die. | 03-17-2016 |
20160077225 | ACTIVE MICROPHONIC NOISE CANCELLATION IN RADIATION DETECTORS - A new adaptive filtering technique to reduce microphonic noise in radiation detectors is presented. The technique is based on system identification that actively cancels the microphonic noise. A sensor is used to measures mechanical disturbances that cause vibration on the detector assembly, and the digital adaptive filtering estimates the impact of these disturbances on the microphonic noise. The noise then can be subtracted from the actual detector measurement. In this paper the technique is presented and simulations are used to support this approach. | 03-17-2016 |
20160077074 | INTERCONNECTED CORRUGATED CARBON-BASED NETWORK - An interconnected corrugated carbon-based network comprising a plurality of expanded and interconnected carbon layers is disclosed. In one embodiment, each of the expanded and interconnected carbon layers is made up of at least one corrugated carbon sheet that is one atom thick. In another embodiment, each of the expanded and interconnected carbon layers is made up of a plurality of corrugated carbon sheets that are each one atom thick. The interconnected corrugated carbon-based network is characterized by a high surface area with highly tunable electrical conductivity and electrochemical properties. | 03-17-2016 |
20160077070 | COLORIMETRIC SENSORS FOR ALKYLATING AGENTS - Methods and kits for detection of alkylating agents are described. The present invention discloses methods and kits comprising sensors for the rapid detection of chemical agents (e.g., alkylating agents) at low concentrations. | 03-17-2016 |
20160075984 | METHODS AND APPARATUS FOR CELL CULTURE ARRAY - Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays. | 03-17-2016 |
20160075878 | Bay-Annulated Indigo (BAI) As An Excellent Electron Accepting Building Block for High Performance Organic Semiconductors - A novel electron acceptor based on bay-annulated indigo (BAI) was synthesized and used for the preparation of a series of high performance donor-acceptor small molecules and polymers. The resulting materials possess low-lying LUMO energy level and small HOMO-LUMO gaps, while their films exhibited high crystallinity upon thermal treatment, commensurate with high field effect mobilities and ambipolar transfer characteristics. | 03-17-2016 |
20160072482 | LOW JITTER TUNABLE VOLTAGE CONTROL OSCILLATOR WITH SELF CALIBRATION CIRCUITS TO REDUCE CHIP FABRICATION PROCESS VARIATION - A voltage controlled oscillator (VCO) which can be configured with a smaller tuning range than is ordinarily required is presented. Ordinarily, the tuning range is selected much broader than the application warrants so that sufficient range is still provided despite VCO process variations. The inventive VCO is able to substantially eliminate the effects of process variation by utilizing a calibration circuit and process, so that variation in VCO device operation is minimized despite substantial process variation. Accordingly, the inventive VCO device is subject to reduced levels of jitter as its range need not be utilized for overcoming process variation arising during device fabrication. | 03-10-2016 |
20160070092 | METHOD AND DEVICE FOR FLUORESCENT IMAGING OF SINGLE NANO-PARTICLES AND VIRUSES - A field-portable fluorescence imaging platform is disclosed that is installed on mobile communications device for imaging of individual nanoparticles or microparticles such as viruses, bacterial, and the like using a light-weight and compact opto-mechanical attachment or housing configured to be removably secured to the mobile communication device. The housing includes a sample holder configured to hold a sample along with a light source and a lens or lens system that is positioned generally opposite the lens in the mobile communication device. An optical filter is disposed in the housing and is interposed between the lens of the housing and the lens of the mobile communication device. A z-adjust stage is disposed in the housing and coupled to the sample holder, the z-adjust stage is configured to adjust the position of the sample holder in a z direction along an optical path passing through the lenses and onto an image sensor contained in the mobile communication device. | 03-10-2016 |
20160068569 | STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS - This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described. | 03-10-2016 |
20160064795 | HOLLOW PLASTIC WAVEGUIDE FOR DATA CENTER COMMUNICATIONS - A wave cable transceiver system is disclosed incorporating an air-core or noble gas filled hollow plastic waveguide. The system may include a transmitter receiver, in-antennas and a tubular plastic waveguide with the inner air-core. The hollow plastic waveguide is a low loss and low dispersion guiding channel for the electromagnetic radiation. | 03-03-2016 |
20160064249 | LOCAL DOPING OF TWO-DIMENSIONAL MATERIALS - This disclosure provides systems, methods, and apparatus related to locally doping two-dimensional (2D) materials. In one aspect, an assembly including a substrate, a first insulator disposed on the substrate, a second insulator disposed on the first insulator, and a 2D material disposed on the second insulator is formed. A first voltage is applied between the 2D material and the substrate. With the first voltage applied between the 2D material and the substrate, a second voltage is applied between the 2D material and a probe positioned proximate the 2D material. The second voltage between the 2D material and the probe is removed. The first voltage between the 2D material and the substrate is removed. A portion of the 2D material proximate the probe when the second voltage was applied has a different electron density compared to a remainder of the 2D material. | 03-03-2016 |
20160061538 | Active Cryogenic Electronic Envelope - A data acquisition module is disclosed for use with electronic components such as superconductive magnets wherein the electronic components and the data acquisition module may reside inside a cryostat. The data acquisition module allows conventional electronic technologies to work inside cryostats at cryogenic temperatures as low as 4° K. This is achieved by management of heat inside the module to keep the module operating at a temperature above the cryogenic temperature. This approach avoids the difficulties that arise from changes in carrier mobility in semiconductors operating at deep cryogenic temperatures. A cryogenic system comprises a cryostat containing a cryogenic fluid and at least one sensor, and a data acquisition module located within the cryostat, the module in communication with the at least one sensor to acquire data, wherein the module comprises a thermal package, a conditioning and digitizing electronic module, a controller module, a power module, and a thermal management module. | 03-03-2016 |
20160054555 | HIGH NUMERICAL APERTURE TELEMICROSCOPY APPARATUS - An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants. | 02-25-2016 |
20160053392 | SYNTHESIS OF NANOPEAPODS BY GALVANIC DISPLACEMENT OF SEGMENTED NANOWIRES - A method for fabricating nanostructures and nanostructures are disclosed, which can include forming a multi-segmented nanowire; and performing a galvanic displacement reaction on the multi-segmented nanowire. The method utilizes template directed electrodeposition to fabricate nanowires with alternating layers of sacrificial/noble metal, enabling a new level of control over particle spacing, aspect ratio, and composition. Moreover, by exploiting the redox potential dependent reaction of galvanic displacement, nanopeapod materials can be extended (semiconductor/metal, p-type/n-type, metal/metal, ferromagnetic/nonmagnetic, etc.) beyond the fundamental metal/metal-oxide nanopeapods synthesized by high temperature techniques. Co/Au and Ni/Au multisegmented nanowires are disclosed, which can be create Te/Au nanopeapods by galvanic displacement, producing Te nanotubes and nanowires with embedded Au particles, respectively. | 02-25-2016 |
20160053344 | SULFONAMIDE-BASED SEPARATION MEDIA FOR RARE EARTH ELEMENT SEPARATIONS - A sulfonamide based rare earth element ion separation media and method of synthesis and use are provided. A bed or column of sulfonamide resin for separations can be prepared by exposing a sulfonate resin to chlorosulfonic acid to form a sulfonyl chloride resin; exposing the sulfonyl chloride resin to aqueous ammonia to form a sulfonamide resin; and then packing the sulfonamide resin into a separation column. Mixtures of lanthanide and other rare earth ions with very similar atomic radii and characteristics can be separated by flowing a mixture of lanthanide ions through a bed of sulfonamide resin followed by a mobile phase of an organic acid such as lactic acid to elute the separated rare earth element ions separated by the sulfonamide resin. Collected fractions of eluate can also be recycled through the sulfonamide media. | 02-25-2016 |
20160053236 | COMPOSITION AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE - Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds. | 02-25-2016 |
20160047653 | ENVIRONMENTALLY ROBUST MICRO-WINEGLASS GYROSCOPE - A method for fabricating an environmentally robust micro-wineglass gyroscope includes the steps of stacking and bonding of at least an inner glass layer and an outer glass layer to a substrate wafer; plastically deforming the inner glass layer into a mushroom-shaped structure and deforming the outer glass layer into a shield capable of extending over the inner glass layer, while leaving the inner and outer glass layers connectable at a central post location; removing the substrate layer and a portion of the inner glass layer so that a perimeter of the inner glass layer is free; and bonding the deformed inner and outer glass layers to a handle wafer. The resulting structure is an environmentally robust micro-wineglass gyroscope which has a double ended supported central post location for the mushroom-shaped structure of the inner glass layer. | 02-18-2016 |
20160045743 | ELECTRICAL CHARGE BALANCING METHOD FOR FUNCTIONAL STIMULATION USING PRECISION PULSE WIDTH COMPENSATION - An apparatus and method for electrical charge balancing when generating a stimulus during functional neural stimulation is presented. A stimulus pulse is generated (cathodic or anodic), and after a selected delay a charge compensating pulse is generated of an opposite polarity. The electrode circuit discontinuously examines electrode voltage after termination of the stimulus pulse, and utilizes this voltage to determine how long to extend the width of the charge compensating pulse. The electrode circuit thus performs accurate electrical charge cancellation to remove residual charges from the electrode by precisely controlling pulse width for an opposing polarity compensating pulse that need not have the same current level as the stimulus pulse. | 02-18-2016 |
20160043278 | NON-POLAR (Al,B,In,Ga)N QUANTUM WELLS - A method of fabricating non-polar a-plane GaN/(Al,B,In,Ga)N multiple quantum wells (MQWs). The a-plane MQWs are grown on the appropriate GaN/sapphire template layers via metalorganic chemical vapor deposition (MOCVD) with well widths ranging from 20 Å to 70 Å. The room temperature photoluminescence (PL) emission energy from the a-plane MQWs followed a square well trend modeled using self-consistent Poisson-Schrodinger (SCPS) calculations. Optimal PL emission intensity is obtained at a quantum well width of 52 Å for the a-plane MQWs. | 02-11-2016 |
20160042912 | LIQUID FLOW CELLS HAVING GRAPHENE ON NITRIDE FOR MICROSCOPY - This disclosure provides systems, methods, and apparatus related to liquid flow cells for microscopy. In one aspect, a device includes a substrate having a first and a second oxide layer disposed on surfaces of the substrate. A first and a second nitride layer are disposed on the first and second oxide layers, respectively. A cavity is defined in the first oxide layer, the first nitride layer, and the substrate, with the cavity including a third nitride layer disposed on walls of the substrate and the second oxide layer that define the cavity. A channel is defined in the second oxide layer. An inlet port and an outlet port are defined in the second nitride layer and in fluid communication with the channel. A plurality of viewports is defined in the second nitride layer. A first graphene sheet is disposed on the second nitride layer covering the plurality of viewports. | 02-11-2016 |
20160039859 | Novel NNA-DNA Adducts as Biomarkers for Detecting Exposure to Thirdhand Smoke - NNA-derived specific adducts represent an integrated biomarker of exposure to thirdhand smoke (THS) as NNA is unique to THS. The NNA-dG covalent binding adduct could serve as such a biomarker, and play a role in identifying individuals exposed to THS, thus providing critical information for early detection and prevention. | 02-11-2016 |
20160039857 | ANTIBACTERIAL COMPOUNDS TARGETING ISOPRENOID BIOSYNTHESIS - With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by interacting with binding pockets, thereby preventing enzyme function. Compounds described herein are also active against | 02-11-2016 |
20160038739 | CIRCUIT ARCHITECTURE FOR HIGH CHANNEL COUNT HIGH-VOLTAGE NEURAL STIMULATOR - A high channel count high-voltage neural stimulator provides an external circuit which communicates power and data to a neural stimulator implant circuit. Data from the external device, such as image data from a camera in an epiretinal application, are communicated to the implant. Multiple pixels circuits, within each implant demultiplex the digital signals, then output separate nerve stimulator outputs from multiple outputs, each configured for connection to a nerve, by sharing a single level conversion driver circuit. In at least one example, the implant circuits can be clustered in a master-slave configuration to increase the number of available neural stimulation outputs. | 02-11-2016 |
20160037806 | METHOD FOR DEBITTERING OLIVES - A method for debittering olives is described. The method includes contacting olive flesh with a granular polymeric resin under conditions sufficient to remove one or more bittering compounds from the olive flesh, thereby debittering olives. | 02-11-2016 |
20160034625 | Network Architectures for Boundary-Less Hierarchical Interconnects - Systems and methods for implementing boundary-less hierarchical networks including methods of generating such networks in accordance with embodiments of the invention are disclosed. In one embodiment, a hierarchical network in an integrated circuit that includes a plurality of computing elements, where the plurality of computing elements have M outputs and N inputs, and a plurality of switches arranged into stages of switches wherein the plurality of computing elements are connected to switches in a first stage, the switches in the first stage are connected to the plurality of computing elements and switches in a second stage, where the switches in the second stage are connected to the switches in the first stage, at least M+1 adjacent computing elements can connect to at least two nearest neighboring computing elements via a stage 1 switch, and every computing element can connect with every other computing element within the hierarchical network. | 02-04-2016 |
20160033528 | Methods for Selecting Peptides that Bind to Disease Specific Antibodies, Disease Specific Peptides and Uses Thereof - Provided herein is a method for selecting and expanding polypeptide epitopes against disease-specific antibodies present in blood across a wide variety of antibody-mediated infectious and autoimmune diseases. In particular, high-throughput selection methods are provided for selecting and expanding disease-relevant polypeptide epitopes against disease-specific antibodies present in a sample from a subject using polypeptide epitope libraries. Also provided are polypeptide epitope sequences, which accurately discriminate subjects with active and remitting Celiac Disease compared to non-Celiac subjects for diagnostic or therapeutic purposes. These peptide epitopes can be employed in methods for diagnosing a subject with Celiac disease. Kits useful in the disclosed methods are also provided. | 02-04-2016 |
20160033476 | SYSTEM AND METHOD FOR UTILIZING EXHALED BREATH FOR MONITORING INFLAMMATORY STATES - A system for monitoring an exhaled breath of a subject is described. A breath collector can be configured to receive exhaled breath from a subject. One or more sensors can be configured to output a concentration of a first gas compound in the received exhaled breath, and to output a concentration of a second gas compound in the received exhaled breath. The second gas compound is used to normalize the concentration of the first gas based on different physiological states of the subject. A processor operably coupled to the one or more sensors is configured to calculate a ratio of the first gas compound to the second gas compound based on the determined concentrations, and to determine a normalized concentration of the first gas compound. This ratio may be monitored to evaluate an inflammatory state of the subject. | 02-04-2016 |
20160033415 | DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS - Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. | 02-04-2016 |
20160032236 | NANOPORE SENSOR FOR ENZYME-MEDIATED PROTEIN TRANSLOCATION - Described herein is a device and method for translocating a protein through a nanopore and monitoring electronic changes caused by different amino acids in the protein. The device comprises a nanopore in a membrane, an amplifier for providing a voltage between the cis side and trans side of the membrane, and an NTP driven unfoldase which processed the protein to be translocated. The exemplified unfoldase is the ClpX unfoldase from | 02-04-2016 |
20160030009 | METHODS AND DEVICES FOR DIAGNOSIS OF BLOOD VESSEL BLOCKAGE OR HEMORRHAGE - A method of diagnosing the occurrence or non-occurrence of a blood vessel blockage or hemorrhage comprises non-invasively applying ultrasound to a location on a patient's body, where the ultrasound is applied in an alternating and pulsed fashion, administering acoustic amplifiers to the patient, monitoring a feedback acoustic response signal of the acoustic amplifiers triggered by the ultrasound, and determining a diagnosis based at least in part on a relationship between an acoustic response signature of the acoustic response signal and a baseline acoustic response signature. | 02-04-2016 |
20160029805 | HEATED AND COOLED CHAIR APPARATUS - Articles of furniture with a system of heating and cooling that can be integrated into a building environmental control network are provided. The heating/cooling system of the article has surfaces of a porous or non-porous, moisture-permeable material allowing convective and evaporative heat exchange from the body surface to the environment. The material covers a plenum that has reflective surfaces to reduce radiant losses and low-wattage fans to circulate air that convectively cools the occupant. Resistance heating may be incorporated at key occupant contact areas in the seat and backrest. Temperature, occupancy and other sensors can be incorporated. A control interface controls the actions of the heating/cooling system of the article and can interact with a network server to transmit measurements of environmental temperatures and occupant selection of control settings that are useful for control of the building's indoor environment. | 02-04-2016 |
20160027842 | SYSTEMS AND METHODS FOR IMPLEMENTING MAGNETOELECTRIC JUNCTIONS - Embodiments of the technology implement DIOMEJ cells. In one embodiment, a DIOMEJ cell includes: an MEJ that includes, a ferromagnetic fixed layer, a ferromagnetic free layer, and a dielectric layer interposed between the fixed and free layers, where the fixed layer is magnetically polarized in a first direction, where the free layer has a first easy axis that is aligned with the first direction, and where the MEJ is configured such that when a potential difference is applied across it, the magnetic anisotropy of the free layer is altered such that the relative strength of the magnetic anisotropy along a second easy axis that is orthogonal to the first easy axis, as compared to the strength of the magnetic anisotropy along the first easy axis, is magnified for the duration of the application of the potential difference; and a diode, where the diode and the MEJ are arranged in series. | 01-28-2016 |
20160027545 | DRIFT-CORRECTED, HIGH-RESOLUTION OPTICAL TRAP AND HIGH-SENSITIVITY ANGULAR INTERFEROMETER - A drift-adjusted interferometer and optical trap are disclosed that employ two reference beams with an optical property that allows them to be separated from the two trapping beams. The reference and trapping beams are combined collinearly and optically inverted so that each reference beam overlays with the opposite trapping beam. Each pair of beams is then focused on a microsphere and the resulting four back-focal plane interferometry signals are monitored such that the relative motion between a given trapping beam with its overlaid reference beam provides a direct measurement of the physical drift occurring due to mechanical drift of the differential path components. | 01-28-2016 |
20160026830 | METHOD AND APPARATUS FOR SOLVING AN OPTIMIZATION PROBLEM USING AN ANALOG CIRCUIT - An analog circuit design is described that solves Linear Programming (LP) or Quadratic Programming (QP) problems. | 01-28-2016 |
20160026767 | NON-INVASIVE NUTRITION MONITOR - An apparatus includes a sensor configured to detect a variable characteristic, the variation of the characteristic including variation indicative of an individual swallowing when the sensor is positioned in a neck area of the individual. The apparatus includes a wireless data communication interface configured to receive information related to the characteristic and transmit the information externally. The sensor may be, for example, an acoustic sensor, a piezoelectric sensor, a capacitive sensor, or a pressure sensor. The apparatus may include a sensor interface to sample a signal from the sensor and provide data related to the signal for transmission externally. A system may use the information related to the characteristic to identify eating habits and type of food eaten. Feedback may be provided to the individual to help the individual change their dietary intake and habits. | 01-28-2016 |
20160024575 | CIRCULATING SMALL NONCODING RNA MARKERS - This application describes small noncoding RNA markers that can be found in a biological sample taken from an individual. The level of such markers are useful for determining the individual's health status, especially in comparison with others. Methods and kits for the use of these markers are provided as well. | 01-28-2016 |
20160024533 | ELECTRO-AUTOTROPHIC SYNTHESIS OF HIGHER ALCOHOLS - The disclosure provides a process that converts CO | 01-28-2016 |
20160023913 | INTERZEOLITE TRANSFORMATION AND METAL ENCAPSULATION IN THE ABSENCE OF AN SDA - Provided is a method of encapsulating a metal in a zeolite. The method comprises inserting a metal precursor into a parent zeolite, and then converting the parent zeolite to a zeolite having a higher framework density than the parent zeolite. The conversion is achieved without the need of an organic structure directing agent. | 01-28-2016 |
20160023912 | SYNTHESIS OF HIGH SILICA ZEOLITE VIA INTERZEOLITE TRANSFORMATION WITHOUT OSDAs - Provided is a method for preparing a zeolite having a Si/Al ratio of at least 10 by interzeolite transformation in the absence of an organic structure directing agent. The method is more cost effective and less equipment intensive as it eliminates the costly organic structure directing agent and the waste treatment at the plant. | 01-28-2016 |
20160022794 | SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA - The present invention provides novel enterobactin-carrier protein conjugates and salmochelin-carrier protein conjugates, such as compounds of Formula (I), and salts thereof. The present invention also provides compositions, kits, and methods that involve the compounds of Formula (I) and are useful in inducing an immune response, treating a bacterial infection and/or inflammatory bowel disease in a subject, preventing a bacterial infection and/or inflammatory bowel disease in a subject, or inhibiting the growth of or killing a bacterium. | 01-28-2016 |
20160021885 | MITIGATION OF ALTERNATE BEARING - Described are compositions and methods to mitigate alternate bearing of perennial crops by use of a natural metabolite. In particular, the present disclosure provides a natural metabolite in the presence or absence of an auxin transport inhibitor to increase floral intensity (flower number) of the return bloom in the spring following the setting of a heavy on-crop to increase the yield of the putative off-crop year and, thus, increase cumulative crop yield. Additionally the present disclosure provides a natural metabolite in combination with one or both of a growth promoting type of plant growth regulator, and a hormone biosynthesis, transport or function inhibiting type of plant growth regulator. | 01-28-2016 |
20160017348 | METHODS AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS TO SPECIFIC LOCI - The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants. | 01-21-2016 |
20160017340 | HIGH-THROUGHPUT CARGO DELIVERY INTO LIVE CELLS USING PHOTOTHERMAL PLATFORMS - Methods, devices, and systems are provided for the delivery of agents (e.g., nucleic acids, proteins, organic molecules, organelles, antibodies or other ligands, 5 etc.) into live cells and/or the extraction of the same from said cells. In various embodiments the photothermal platforms and systems incorporating such photothermal platforms are provided that permit efficient, high-throughput cargo delivery into live cells. | 01-21-2016 |
20160017208 | MICROBIAL CONCRETION AS A METHOD FOR CONTROLLING WORMHOLE EVENTS DURING OIL RECOVERY FROM UNCONSOLIDATED MATRICES - The present disclosure relates to methods of controlling wormhole formation in a borewell environment of reservoir systems, such as oil reservoirs, by inducing authigenic mineral-precipitating bacteria to precipitate authigenic rock minerals that consolidate unconsolidated rock matrices. | 01-21-2016 |
20160017206 | METHODS FOR IMMEDIATE SOURING CONTROL IN GASES OR FLUIDS PRODUCED FROM SULFIDOGENIC RESERVOIR SYSTEMS - The present disclosure relates to methods of controlling the sulfide (S | 01-21-2016 |
20160016322 | BLADE WITH A VARYING CUTTING ANGLE - A blade is described. This blade includes a substrate having two surfaces that meet at a cutting edge of the blade. At a given location along a length of the cutting edge, the two surfaces are at an angle with respect to one another. Moreover, angles between the two surfaces are different at at least two locations along the length of the blade. In particular, the angles between the two surfaces may vary along the length of the blade. Furthermore, the blade may include islands having top surfaces positioned at other locations along the length of the blade. These islands may protrude above the cutting edge to protect skin of a user when the blade is used to cut hair. In addition, the islands may include fluidic channels that provide a fluid (such as air or a lubricant) at the top surfaces of the islands when the blade is used. | 01-21-2016 |
20160015995 | PORTABLE TRANSCUTANEOUS MAGNETIC STIMULATOR AND SYSTEMS AND METHODS OF USE THEREOF - A device and method are provided for treatment of peripheral nerve pain using a tMS stimulator for directing a low frequency, focused magnetic flux to a treatment area. A control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module receive, generate and transmit feedback and control settings relating to a treatment parameters. The tMS stimulator may be configured in different sizes and shapes to provide varying pulse and magnetic field strengths. Guidance tools and measurement sensors may be provided to aid in positioning and directing the magnetic flux. | 01-21-2016 |
20160015319 | SYSTEM FOR HEALTH MONITORING ON PROSTHETIC AND FIXATION DEVICES - A monitoring apparatus for a human body includes a node network with at least one motion sensor and at least one acoustic sensor. A processor is coupled to the node network, and receives motion information and acoustic information from the node network. The processor determines from the motion information and the acoustic information a source of acoustic emissions within the human body by analyzing the acoustic information in the time domain to identify an event envelope representing an acoustic event, determining a feature vector related to the event envelope, calculating a distance between the feature vector and each of a set of predetermined event silhouettes, and identifying one of the predetermined event silhouettes for which the distance is a minimum. | 01-21-2016 |
20160006453 | METHOD FOR DATA COMPRESSION AND TIME-BANDWIDTH PRODUCT ENGINEERING - A method and apparatus for compression of digital and analog data utilizing an anamorphic spectrum transformation to warp an analog or digital signal to provide time-bandwidth compression after sampling is performed on the warped signal. The anamorphic spectrum transformation performs reallocating samples to assign more samples to fine features with high frequency waveform portions and fewer samples to coarse features with low frequency portions of the analog temporal signal, resulting in shorter record length and fewer number of samples. | 01-07-2016 |
20160005949 | DEVICES AND METHODS FOR CONTROLLlNG MAGNETIC ANISTROPY WITH LOCALIZED BIAXIAL STRAIN IN A PIEZOELECTRIC SUBSTRATE - Devices and methods for controlling magnetic anisotropy and orientation of magnetic single domain structures between stable states are provided based on piezoelectric thin films and patterned electrodes. By using patterned electrodes, piezoelectric strain is manipulated to achieve a highly localized biaxial strain in a piezoelectric substrate and rotate the magnetic anisotropy of magnetic materials. Reorientation of a magnetic single domain between different stable states is accomplished by pulsing voltage across pairs of electrodes. Since only a small region surrounding the electrodes is strained, the methods can be applied to arrays of indexed magnetic elements and to piezoelectric thin films clamped to silicon base substrates. | 01-07-2016 |
20160003805 | METHODS FOR IDENTIFYING ARTHROPOD REPELLENTS AND ATTRACTANTS, AND COMPOUNDS AND COMPOSITIONS IDENTIFIED BY SUCH METHODS - Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided herein are also screening methods for identifying compounds for use as an arthropod attractant based on activation of the cpA neuron. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds. | 01-07-2016 |
20160003741 | APPARATUS AND METHODS FOR FLUORESCENCE IMAGING USING RADIOFREQUENCY-MULTIPLEXED EXCITATION - Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques. | 01-07-2016 |
20160003618 | FREQUENCY READOUT GYROSCOPE - A frequency readout gyroscope is provided, having 2 or 3 axes, in which the frequency of the carrier associated with the oscillation of the proof mass changes while the amplitude stays constant. The invention departs from conventional gyroscopes which rely on measuring transducer sense axis displacement (amplitude modulation) to determine angular input rate. The invention utilizes what could be termed a form of frequency modulation, such as evaluating frequency phase difference between the axes of modulation. Examples include gyroscopes having either a quadrature or Lissajous FM mode of operation, in which angle random walk contribution from the electronics is reduced by approximately two orders of magnitude. | 01-07-2016 |
20160002272 | SURFACE FUNCTIONALIZED POROUS SILICON MATERIAL AND METHOD OF MAKING THEREOF - The present invention relates generally to a surface functionalized porous containing material and method of making thereof. | 01-07-2016 |
20160000752 | METHOD FOR INCREASING MUSCLE GROWTH BY BLOCKING SIRTUIN ACTIVITY - Systems and methods are described providing therapeutic preparations of sirtuin inhibitors, such as SIRT1 inhibitors, for stimulating load-induced skeletal muscle growth in the body of a patient. The natural stimulation of SIRT1 activity can be suppressed through increased caloric intake and loading in conjunction with the inhibition of sirtuin activity to improve the inhibitory effect. In addition, known muscle growth promoting agents such as amino acids and hormones can be administered at the same time as the sirtuin inhibitor. The size of the tissue structure to be treated or the body size may be used to determine the therapeutic dose of sirtuin inhibitor. The sirtuin inhibitor and muscle stimulating agents are either locally or systemically delivered at therapeutic doses for the desired effect. The SIRT1 inhibitor Splitomycin is particularly effective. | 01-07-2016 |
20160000079 | Novel small molecule inhibitors of biofilm formation and the novel use of previously identified compounds for inhibition of biofilm formation and applications for drug therapy and medical device coating - Novel compounds and the novel use a class of previously identified small molecules for the inhibition of biofilm formation. Inhibition of biofilm formation can play a very important role in contributing to pathogenicity. Bacteria in the biofilm state have been shown to be 10-10,000-fold less susceptible to antibiotic treatment. Estimations made by the Centers for Disease Control (CDC) and the National Institutes of Health (NIH) attribute 65% to 80% of human infections as biofilm mediated. Consequently, biofilm formation is often responsible for chronic infections due to bacterial persistence despite antibiotic treatment. | 01-07-2016 |
20150382416 | SWITCHABLE LUMINANCE LED LIGHT BULB - A switchable luminance LED light bulb, including embodiments that may be used with any common commercial fitting. | 12-31-2015 |
20150377906 | BIOMARKERS FOR RADIATION EXPOSURE - Panels of 1-, 2-, 3-, and 4 protein-biomarker for diagnostic and prognostic methods to determine a subject's radiation exposure and discriminates between persons who have been exposed to various levels of radiation, 1-5 days after exposure. | 12-31-2015 |
20150377897 | METHODS FOR IDENTIFYING ARTHROPOD REPELLENTS BASED ON MODULATION OF SPECIFIC IONOTROPIC RECEPTORS, AND COMPOUNDS AND COMPOSITIONS IDENTIFIED BY SUCH METHODS - Provided herein are screening methods for identifying arthropod repellent compounds based on modulation of ionotropic receptors, including an Ir40a receptor, an Ir93a receptor and an Ir25a receptor. Further provided are screening systems related to these methods. Such systems may include a sample that has one or more of the ionotropic receptors; and one or more compounds that each is a repellent for at least one arthropod species, wherein the one or more compound each modulates the activity of such ionotropic receptor(s). Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds. | 12-31-2015 |
20150377856 | COMPENSATED PATCH-CLAMP AMPLIFIER FOR NANOPORE POLYNUCLEOTIDE SEQUENCING AND OTHER APPLICATIONS - A compensated patch-clamp system for polynucleotide sequencing and other applications. | 12-31-2015 |
20150376656 | BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS - Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate. | 12-31-2015 |
20150376455 | COMPOSITIONS FOR CONTROLLED ASSEMBLY AND IMPROVED ORDERING OF SILICON-CONTAINING BLOCK COPOLYMERS - The invention provides compositions and methods for inducing and enhancing order and nanostructures in organosilicon block copolymers compositions by including certain organic additives in such compositions that include one or more moieties comprising a hydrogen bond acceptor or a hydrogen bond donor. Such block copolymer compositions may be used, for example, as a mask for lithographic patterning as is used, for example, during various stages of semiconductor device fabrication. | 12-31-2015 |
20150376277 | ANTI-CD83 ANTIBODIES AND USE THEREOF - The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis. | 12-31-2015 |
20150376153 | METHODS FOR PREPARING ALKYLFURANS - Provided herein are methods for preparing alkylfurans, such as 2,5-dialkylfurans and 2-alkylfurans. Furfural or 5-alkylfurfural can be reacted with aniline or diaminobenzene, or derivatives thereof, to form the corresponding imine, which can be reduced to form alkylfurans and to regenerate the aniline or diaminobenzene, or derivatives thereof. The alkylfuran may be, for example, 2,5-dimethylfuran or 2-methylfuran. | 12-31-2015 |
20150375262 | METHOD OF FORMING ORIENTED BLOCK COPOLYMER LINE PATTERNS, BLOCK COPOLYMER LINE PATTERNS FORMED THEREBY, AND THEIR USE TO FORM PATTERNED ARTICLES - A block copolymer film having a line pattern with a high degree of long-range order is formed by a method that includes forming a block copolymer film on a substrate surface with parallel facets, and annealing the block copolymer film to form an annealed block copolymer film having linear microdomains parallel to the substrate surface and orthogonal to the parallel facets of the substrate. The line-patterned block copolymer films are useful for the fabrication of magnetic storage media, polarizing devices, and arrays of nanowires. | 12-31-2015 |
20150373369 | ANAMORPHIC STRETCH IMAGE COMPRESSION - A feature-selective compression method and system are described which uses a transformation causing feature-selective stretching of the image being compressed. As a result, additional samples are allocated to sharp features where they are needed, and less to coarse features where they are redundant. The method can be applied to still and video images, whether they are monochrome or color images or 3D images, and operates in open-loop fashion and does not require prior knowledge of the image. The method can be applied by itself or combined with other types of compression (i.e., JPEG, WebP) to further compress the image. | 12-24-2015 |
20150372456 | HIGH POWER BLUE-VIOLET III-NITRIDE SEMIPOLAR LASER DIODES - A high power blue-violet Ill-nitride semi-polar laser diode (LD) with an output power in excess of 1 W, a slope efficiency of more than 1 W/A, and an external quantum efficiency (EQE) in excess of 25% and more preferably, in excess of 35%. These operating characteristics make these laser diodes suitable for use in solid state lighting systems. | 12-24-2015 |
20150371849 | METHOD FOR THE REUSE OF GALLIUM NITRIDE EPITAXIAL SUBSTRATES - A method for the reuse of gallium nitride (GaN) epitaxial substrates uses band-gap-selective photoelectrochemical (PEC) etching to remove one or more epitaxial layers from bulk or free-standing GaN substrates without damaging the substrate, allowing the substrate to be reused for further growth of additional epitaxial layers. The method facilitates a significant cost reduction in device production by permitting the reuse of expensive bulk or free-standing GaN substrates. | 12-24-2015 |
20150371151 | ENERGY INFRASTRUCTURE SENSOR DATA RECTIFICATION USING REGRESSION MODELS - A system and method are provided for physical data rectification using regression models. For example, the physical data may be energy infrastructure sensor data. The system may perform an estimation of sensor data during periods of data dropout using a regression model. The system may assess the accuracy of regression models through the comparison of probability distribution functions of physical data estimated using the regression model and actual physical data. | 12-24-2015 |
20150369800 | HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS - The disclosure provides method and composition utilizing fluorescent amino acids and fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors. | 12-24-2015 |
20150367149 | COBINAMIDE-BASED MATERIALS FOR OPTICAL SENSING AND GAS REMOVAL - This disclosure concerns materials for detecting and removing gaseous chemical agents (e.g., cyanide, cyanogen, sulfide, nitrite, nitric oxide, and combinations thereof), devices including the materials, and methods of making and using the disclosed materials. Embodiments of the disclosed materials include a support material impregnated with cobinamide and/or a cobinamide derivative. | 12-24-2015 |
20150366943 | MOBILIZATION OF HEMATOPOIETIC STEM CELLS FROM BONE MARROW TO BLOOD USING A COMBINATION OF A ROBO4 RECEPTOR ANTAGONIST AND A CXCR4 ANTAGONIST OR hrVEGF-165 AND A CXCR4 ANTAGONIST - The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used in clinical treatment using hematopoietic transplantation, particularly to those relating to treatment of cancer and metastasis. The compositions regulate mobilization of hematopoietic stem cells (HSCs) between bone marrow (BM) and the peripheral blood (PB). | 12-24-2015 |
20150366686 | APPARATUS AND METHODS FOR BIDIRECTIONAL HYPERELASTIC STENT COVERS - An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented. | 12-24-2015 |
20150366499 | SEM SCANNER SENSING APPARATUS, SYSTEM AND METHODOLOGY FOR EARLY DETECTION OF ULCERS - A handheld, conforming capacitive sensing apparatus configured to measure Sub-Epidermal Moisture (SEM) as a mean to detect and monitor the formation of pressure ulcers. The device incorporates an array of electrodes which are excited to measure and scan SEM in a programmable and multiplexed manner by a battery-less RF-powered chip. The scanning operation is initiated by an interrogator which excites a coil embedded in the apparatus and provides the needed energy burst to support the scanning/reading operation. Each electrode measures the equivalent sub-epidermal capacitance corresponding and representing the moisture content. | 12-24-2015 |
20150366482 | SYSTEM AND METHOD FOR MODELING BRAIN DYNAMICS IN NORMAL AND DISEASED STATES - A system and method is provided for modeling brain dynamics in normal and diseased states. | 12-24-2015 |
20150366193 | COMPOSITION WITH HIGH ANTIMICROBIAL ACTIVITY AND LOW TOXICITY - Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections. | 12-24-2015 |
20150364755 | Silicon Oxide (SiO) Anode Enabled by a Conductive Polymer Binder and Performance Enhancement by Stabilized Lithium Metal Power (SLMP) - Silicon alloys have the highest specific capacity when used as anode material for lithium-ion batteries, however, the drastic volume change inherent in their use causes formidable challenges toward achieving stable cycling performance. Large quantities of binders and conductive additives are typically necessary to maintain good cell performance. In one embodiment of the invention, only 2% (by weight) functional conductive polymer binder without any conductive additives was successfully used with a micron-size silicon monoxide (SiO) anode material, demonstrating stable and high gravimetric capacity (>1000 mAh/g) for ˜500 cycles and more than 90% capacity retention. Prelithiation of this anode using stabilized lithium metal powder (SLMP®) improves the first cycle Coulombic efficiency of a SiO/NMC full cell from ˜48% to ˜90%. This combination enables good capacity retention of more than 80% after 100 cycles at C/3 in a lithium-ion full cell. | 12-17-2015 |
20150364753 | CONTROLLED POROSITY IN ELECTRODES - Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries, and can include low tortuosity in the primary direction of ion transport during charge and discharge of the battery. In some embodiments, the electrodes can have a high volume fraction of electrode active material (i.e., low porosity). The attributes outlined above can allow the electrodes to be fabricated with a higher energy density, higher capacity per unit area of electrode (mAh/cm | 12-17-2015 |
20150363550 | METHODS FOR GENOME ASSEMBLY AND HAPLOTYPE PHASING - The disclosure provides methods to assemble genomes of eukaryotic or prokaryotic organisms. The disclosure further provides methods for haplotype phasing and meta-genomics assemblies. | 12-17-2015 |
20150361060 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides nucleophilic hydroxyimino-acetamido alkylamine antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). The hydroxyimino-acetamido alkylamines of the invention are designed to fit within AChE active center gorge dimensions, bind with reasonable affinity, and react with the conjugated phosphate atom in the gorge. The hydroxyimino-acetamido alkylamines of the invention are also designed to possess ionization states that govern affinity and reactivity for the two linked hAChE re-activation steps. In alternative embodiments, the invention provides pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound of the invention. | 12-17-2015 |
20150360236 | METHODS AND DEVICES FOR SORTING CELLS AND OTHER BIOLOGICAL PARTICULATES - An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The preferred OET-DEP devices generally comprise a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a localized virtual electrode with a DEP electric field gradient of selected intensity along with input and a plurality of output fluidic channels. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes. | 12-17-2015 |
20150359150 | Strawberry cultivars - The invention relates to new strawberry cultivars ( | 12-10-2015 |
20150357075 | METHODS AND DEVICES FOR IN SITU SYNTHESIS OF METAL OXIDES IN CARBON NANOTUBE ARRAYS - A method for controlling microstructural and nanostructural arrangement of nominally-aligned arrays of carbon nanotubes (CNTs) is disclosed. The method comprises synthesizing metal oxide particles in situ in nominally-aligned arrays of carbon nanotubes (CNTs) after synthesis of CNTs. The particles can be SnO | 12-10-2015 |
20150355760 | MULTI-MODAL SYSTEM AND METHOD TO IMPROVE HUMAN MEMORY USING A VIDEO GAME - A multi-modal system to improve human memory using a video game comprises a multi-modal criteria having a task object for the video game and stimulus sets. There is also provided a multi-modal method to improve human memory using a video game by providing a video game comprising multi-modal criteria, having a task object for the video game, and having stimulus sets. | 12-10-2015 |
20150355073 | SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES - A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet. The fluidic pathway includes a delivery region configured to receive the plurality of particles from the inlet and focus the plurality of particles from a random distribution to a focused state, a deformation region defining an intersection located downstream of the delivery region and coupled to the outlet, and wherein the deformation region is configured to receive the plurality of particles from the delivery region and to transmit each particle in the plurality of particles into the intersection from a single direction, a first branch fluidly coupled to the deformation region and configured to transmit a first flow into the intersection, and a second branch fluidly coupled to the deformation region and configured to transmit a second flow, substantially opposing the first flow, into the intersection, wherein the first flow and the second flow are configured to induce extension of one or more particles in the plurality of particles. | 12-10-2015 |
20150355060 | METHOD AND DEVICE FOR ISOLATING CELLS FROM HETEROGENEOUS SOLUTION USING MICROFLUIDIC TRAPPING VORTICES - A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region. | 12-10-2015 |
20150353939 | Growth Arrested Cells Useful for Producing Compounds - The present invention provides for a genetically modified host cell in a growth-arrested state producing an antibiotic. | 12-10-2015 |
20150353693 | Rapid Fabrication of Hierarchically Structured Supramolecular Nanocomposite Thin Films in One Minute - Functional nanocomposites containing nanoparticles of different chemical compositions may exhibit new properties to meet demands for advanced technology. It is imperative to simultaneously achieve hierarchical structural control and to develop rapid, scalable fabrication to minimize degradation of nanoparticle properties and for compatibility with nanomanufacturing. The assembly kinetics of supramolecular nanocomposite in thin films is governed by the energetic cost arising from defects, the chain mobility, and the activation energy for inter-domain diffusion. By optimizing only one parameter, the solvent fraction in the film, the assembly kinetics can be precisely tailored to produce hierarchically structured thin films of supramolecular nanocomposites in approximately one minute. Moreover, the strong wavelength dependent optical anisotropy in the nanocomposite highlights their potential applications for light manipulation and information transmission. The present invention opens a new avenue in designing manufacture-friendly continuous processing for the fabrication of functional nanocomposite thin films. | 12-10-2015 |
20150353614 | Synthetic Transcription Factor and Uses Thereof - The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P). | 12-10-2015 |
20150351722 | Integrated Multimodality Intravascular Imaging System that Combines Optical Coherence Tomography, Ultrasound Imaging, and Acoustic Radiation Force Optical Coherence Elastography - A method of using an integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PR-ARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT method, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies to distinguish tissues with varying stiffness, to identify tissues with different biomechanical properties and to measure structural and mechanical properties simultaneously. | 12-10-2015 |
20150348716 | ASYMMETRIC HYBRID SUPERCAPACITORS BASED ON NANOTUBE NANOWIRE COMPOSITES - An asymmetric supercapacitor includes a first structure and a second structure spaced apart from said second structure. One of the structures comprises an anode, and the other of the first and second structures comprises a cathode, wherein the first structure comprises an activated carbon electrode, and the second structure comprises a nanocomposite electrode. The nanocomposite electrode comprises a first network of nanowires that are interpenetrating with a second network of carbon nanotubes. | 12-03-2015 |
20150346303 | HIGH SPATIAL AND TEMPORAL RESOLUTION DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING - A method for high spatial and temporal resolution dynamic contrast enhanced magnetic resonance imaging using a random subsampled Cartesian k-space using a Poisson-disk random pattern acquisition strategy and a compressed sensing reconstruction algorithm incorporating magnitude image subtraction is presented. One reconstruction uses a split-Bregman minimization of the sum of the L1 norm of the pixel-wise magnitude difference between two successive temporal frames, a fidelity term and a total variation (TV) sparsity term. | 12-03-2015 |
20150344924 | POLYMER ENHANCEMENT OF ENZYMATIC ACTIVITY - Provided herein are methods for enhancing enzymatic activity using certain polymers that may be optionally attached to an enzyme. The polymers may be thermally-responsive polymers, including poly N-isopropylacrylamide or poly N-isopropylmethacrylamide. The polymer may also be a copolymer with at least two different monomer residues. The monomer residues may have a structure of formula (I): | 12-03-2015 |
20150344472 | SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION - Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation. | 12-03-2015 |
20150342699 | VIDEO-GUIDED CHEST TUBE INSERTION SYSTEM - A chest tube placement apparatus is provided that has an elongate body with a rigid tip that is disposed within the interior of a flexible chest tube and an inflatable member mounted to the body is inflated and the apparatus is then inserted in a prepared location in the chest wall of a patient. The body of the apparatus has at least one axial material transfer channel with a tip port that permits the injection of anesthetic or the aspiration of gases or liquids at the tip. The body also has a light and video camera and display to allow the visualization of the internal structures of the patient during chest tube placement. Once placed and the fluids and gases aspirated, the inflatable member is deflated and the apparatus is removed from the interior of the placed chest tube. | 12-03-2015 |
20150338419 | Method for the Determination of Biomolecule Turnover Rates - Disclosed is a method for determining the turnover rate of biomolecules in a subject, which include administering to the subject, 2H20 in an amount sufficient to label biomolecules in the subject with 2H. Samples are collected from the subject at one or more time points and isotopomers are detected for the labeled biomolecules in the samples. The fractional abundance is determined for the isotopomers of the biomolecules in the samples and the biomolecule turnover rates of the one or more labeled biomolecules is determined based on the fractional abundance of the isotopomers. A computer-implemented method is also disclosed for determining the turnover rate of one or more biomolecules in subject. In certain other embodiments, a system for determining protein turnover rates in a subject is also provided. Also provided in certain embodiments is a computer program product for determining protein turnover rates in a subject. | 11-26-2015 |
20150336659 | HYPERSONIC LAMINAR FLOW CONTROL - A novel passive control technique for laminar flow over air transportation vehicles and space reentry vehicles flying at high supersonic and hypersonic speeds is disclosed. The control of laminar flow can be achieved by applying an array of surface roughness elements in the region before the laminar-turbulent transition. For example, an array of two-dimensional rings, stripes, or closely packed three-dimensional isolated roughness elements may be used to stabilize the instability waves and delay transition. The roughness elements may have a height between 40% and 60% of the local boundary-layer thickness. The exact location, height, and spacing of surface roughness elements may be determined by a numerical simulation strategy based on the most unstable second mode, e.g. using known e | 11-26-2015 |
20150334567 | SENSOR-ASSISTED BIOMETRIC AUTHENTICATION FOR SMARTPHONES - During a technique for authenticating a user using a portable electronic device (such as a smartphone) while preventing successful 2D media attacks and virtual-camera attacks, the portable electronic device provides an instruction to a user to move the portable electronic device relative to the user's face. Then, using an imaging sensor in the portable electronic device, the portable electronic device acquires, a series of images while the portable electronic device is at different positions or orientations relative to the user's face, where the series of images include at least two images relative to a symmetry axis of the user's face (such as the midline). Moreover, the portable electronic device determines a change in a sign of a nose angle in at least the two images. Next, the portable electronic device authenticates the user based on at least one of the series of images using a facial-recognition technique. | 11-19-2015 |
20150332749 | VOLTAGE-CONTROLLED MAGNETIC ANISOTROPY (VCMA) SWITCH AND MAGNETO-ELECTRIC MEMORY (MERAM) - Voltage controlled magnetic tunnel junctions and memory devices are described which provide efficient high speed switching of non-volatile magnetic devices at high cell densities. Implementations are described which provide a wide range of voltage control alternatives with in-plane and perpendicular magnetization, bidirectionally switched magnetization, and control of domain wall dynamics. | 11-19-2015 |
20150330992 | RAPID DISCOVERY AND SCREENING OF ENZYME ACTIVITY USING MASS SPECTROMETRY - Described herein are methods, systems, and compositions for detecting enzyme activity. In some embodiments, the reaction product(s) are coupled with a mass tag, and the enzyme activity is determiner by analyzing the reaction product(s). The enzyme assays can be performed using mass spectrometry, for example nanostructure-initiator mass spectrometry (NIMS). Also described are methods, systems, and compositions for monitoring enzymatic degradation process of a substrate sample, for example a biomass. | 11-19-2015 |
20150330964 | NOVEL APPROACH TO ASTHMA INHALER COMPLIANCE USING BREATH MEASUREMENT OF TETRAFLUOROETHANE - The invention relates to measuring the effectiveness and an compliance of inhaler medication, such as for asthma treatment. In one embodiment, the invention provides a method of determining the effectiveness of an inhaler medication, comprising taking a measurement of HFA-134(a) from an exhaled breath of an individual after the individual has inhaled a medication, and determining an effective administration of the medication based on the presence of a high level of HFA-134(a). | 11-19-2015 |
20150329984 | THIN FILM DEPOSITION APPARATUS AND THIN FILM DEPOSITION METHOD USING ELECTRIC FIELD - A thin film deposition apparatus and a thin film deposition method using an electric field are provided. The thin film deposition apparatus includes: a first substrate; a plurality of electrodes in a 2D arrangement on the first substrate; and a solution provided on the plurality of electrodes and in which charged nanoparticles are distributed, wherein the charged nanoparticles are selectively deposited on at least a part of the plurality of electrodes by independently applying a voltage to each of the plurality of electrodes. | 11-19-2015 |
20150329599 | PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES - The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the | 11-19-2015 |
20150327783 | NONINVASIVE 4-D TIME-RESOLVED DYNAMIC MAGNETIC RESONANCE ANGIOGRAPHY - A method for non-contrast enhanced 4D time resolved dynamic magnetic resonance angiography using arterial spin labeling of blood water as an endogenous tracer and a multiphase balanced steady state free precession readout is presented. Imaging can be accelerated with dynamic golden angle radial acquisitions and k-space weighted imaging contrast (KWIC) image reconstruction and it can be used with parallel imaging techniques. Quantitative tracer kinetic models can be formed allowing cerebral blood volume, cerebral blood flow and mean transit time to be estimated. Vascular compliance can also be assessed using 4D dMRA by synchronizing dMRA acquisitions with the systolic and diastolic phases of the cardiac cycle. | 11-19-2015 |
20150324982 | AUTOMATED IMAGE SYSTEM FOR SCORING CHANGES IN QUANTITATIVE INTERSTITIAL LUNG DISEASE - Automated image analysis systems and methods are disclosed to quantify change in fibrosis and interstitial lung disease. The system generates scoring changes in Quantitative Interstitial Lung Disease (QILD) by filtering the uploaded images to minimize cross-site variability within images, sampling from a grid of pixels or voxels within the CT images, classifying individual pixels or voxels within downloaded images based on one or more selected texture features, generating a QILD score for each image based on selected features within the image, and calculating a transition between QILD scores within the plurality of CT images. | 11-12-2015 |
20150323539 | BLOOD MARKERS FOR LUNG CANCER PREDISPOSITION - The invention provides a method for detection of lung cancer, or predisposition to lung cancer, in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of lung cancer, or predisposition to lung cancer. The method can be adapted for quantitatively monitoring the efficacy of treatment of lung cancer in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitrotyrosine oxidative activity (protein nitrosylation in leukocytes). This unexpected discovery of markers of systemic genotoxicity that can be tested using circulating leukocytes enables detection of lung cancer, or predisposition to lung cancer, with a relatively simple and minimally invasive assay using peripheral blood. | 11-12-2015 |
20150323500 | A SPATIALLY ALTERNATING ASYMMETRIC FIELD ION MOBILITY SPECTROMETRY - One embodiment of the present disclosure provides an ion mobility spectrometry (IMS) device for performing chemical analysis. The IMS device includes a first set of electrodes arranged linearly in a first direction and separated by a first set of gaps. The IMS device includes a second set of electrodes positioned directly opposing the first set of electrodes to match the first set of electrodes on a one-to-one basis, wherein the second set of electrodes are separated by a second set of gaps. The IMS device includes a drift region between the first set of electrodes and the second set of electrodes, wherein charged particles enter at a first end of the drift region and traverse the drift region along the first direction. The IMS device additionally includes a detector positioned at a second end of the drift region and configured to receive charged particles exiting the drift region. | 11-12-2015 |
20150322286 | Polymerized Metal-Organic Material for Printable Photonic Devices - To manufacture a nanophotonic device, a metal oxide precursor is mixed with an organic acid, an organic polymer and a photoinitiator in a solvent to form a dispersion comprising a hybrid organic-inorganic phase. A film is formed on a substrate form the dispersion, the film including the hybrid organic-inorganic phase. The film is annealed to transform the hybrid organic-inorganic phase into an inorganic phase. | 11-12-2015 |
20150320693 | VIRAL VECTOR NANOCAPSULE FOR TARGETING GENE THERAPY AND ITS PREPARATION - The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies. | 11-12-2015 |
20150320575 | INTUITIVE PROSTHETIC INTERFACE - A prosthetic device is controlled based on measured electrical signals corresponding to muscle activity in a lower-extremity anatomical analog to a dysfunctional or absent portion of an upper extremity of an individual. In particular, an activity monitoring device measures electrical signals corresponding to muscle activity in the lower-extremity anatomical analog. Then, a communication device communicates information specifying the electrical signals to a pattern-recognition device. The pattern-recognition device identifies a natural mode of movement of the lower-extremity anatomical analog based on the information. For example, the natural mode of movement may be identified using a pattern-recognition technique. Next, the pattern-recognition device provides a control signal to a prosthetic device associated with the dysfunctional or absent portion of the upper extremity, where the control signal specifies a natural mode of movement of the prosthetic device that is an analog to the natural mode of movement of the lower-extremity anatomical analog. | 11-12-2015 |
20150320020 | FIBROTIC NON-HUMAN ANIMAL, AND USE THEREOF - The present invention provides a non-human animal IKKβ which shows fibrosis of tissue, since it lacks IKKβ gene in a myofibroblast- and/or smooth muscle cell-specific manner. Since the non-human animal shows pathology highly similar to scleroderma, it is extremely useful as an animal model of scleroderma. | 11-12-2015 |
20150318856 | GRAPHENE-BASED NON-BOOLEAN LOGIC CIRCUITS - A dual-gate transistor having a negative differential resistance (NDR) region is disclosed. The dual-gate transistor includes a back-gate, a zero-bandgap graphene layer disposed on the back-gate, a top-gate disposed on a portion of the zero-bandgap graphene layer adjacent to the top-gate, and a drain disposed on a portion of the zero-bandgap graphene layer adjacent to the top-gate and displaced from the source. Also included is a dynamic bias controller configured to simultaneously sweep a source-drain voltage and a top-gate voltage across a Dirac point to provide operation within the NDR region. Operation within the NDR region is employed to realize non-Boolean logic functions. Graphene-based non-Boolean logic circuits are constructed from pluralities of the disclosed dual-gate transistor. Pattern recognition circuitry for operation between 100 GHz and 500 GHz is also disclosed via the graphene-based non-Boolean logic circuits. | 11-05-2015 |
20150316547 | Electrophoretic Separation Devices and Methods for Using the Same - Electrophoretic separation devices and methods for using the same are provided. Aspects of the devices include a polymeric separation medium that includes a plurality of microwells. Also provided are methods, systems and kits in which the subject devices find use. The devices and methods find use in a variety of different electrophoretic separation applications. | 11-05-2015 |
20150315775 | ARCHIMEDEAN CAGES, POLYHEDRA, AND NANOTUBE STRUCTURES AND METHODS - A method for designing a structure includes selecting an initial cage, defining a secondary cage by positioning a plurality of tiles, reduced tiles, or larger patches obtained or derived from a selected one of the uniform Archimedean tilings over the faces of the initial cage, resizing edges of the secondary cage such the cage is equilateral, and planarizing the cage faces. In an embodiment the patch comprising a network of edges and vertices from a uniform tiling decorates the faces of a polyhedron to define a non-polyhedral cage that is transformed by planarizing the faces. In an embodiment the secondary cage comprises tiles derived from an Archimedean tiling that decorate faces of the initial cage comprising a polyhedron. In an embodiment the secondary cages resemble a nanotube. | 11-05-2015 |
20150315645 | METHODS OF IDENTIFYING BIOMARKERS ASSOCIATED WITH OR CAUSATIVE OF THE PROGRESSION OF DISEASE - Provided are methods of identifying biomarkers that cause or promote progression of disease. The successful application of the methods is demonstrated by the identification of biomarkers associated with and/or causative of the onset and/or progression and/or severity and/or recurrence of glaucoma and POAG. Many of these biomarkers were not previously associated with glaucoma or POAG. Predictive methods are also described, as well as applications in prognosis, diagnosis, and therapy. Testing for onset, progression, severity, and/or recurrence can be carried out. A key advantage in at least some embodiments is that a patient can receive earlier treatment for the disease such as POAG by use of the methods, screenings, and predictions described herein. Another key advantage in at least some embodiments is that a patient can receive more personalized or particular treatment for the disease such as POAG by use of the methods, screenings, and predictions described herein. | 11-05-2015 |
20150315621 | ONE-POT FERMENTATION PROCESS FOR SIMVASTATIN PRODUCTION - Simvastatin is a drug used in treatment of hypercholesterolemia because of its inhibitory activities towards cholesterol biosynthesis. The technology described herein is a novel method of biosynthesizing Simvastatin directly from an engineered microbial host (such as | 11-05-2015 |
20150313915 | ANTICONVULSANT ACTIVITY OF STEROIDS - The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone. | 11-05-2015 |
20150313497 | Real-time Cortical Mapping - Methods of cortical mapping in real-time are provided. Aspects of the methods include performing real-time processing of signals indicative of a subject's brain activity by applying one filter or more to the signals, wherein the processing is in the absence of averaging based on time. Systems for cortical mapping in real-time are also provided. The methods and systems are useful in research, diagnostic, and therapeutic applications. | 11-05-2015 |
20150312083 | SELF TRACK SCHEME FOR MULTI FREQUENCY BAND SERIALIZER DE-SERIALIZER I/O CIRCUITS - A serializer and de-serializer circuit having self tracking circuitry which is particularly well-suited for use in communicating digital data from one integrated circuit (chip) to another for implementing chip-to-chip communications is presented. The circuits are scalable and utilize a multi-frequency modulation mechanism (e.g., QAM) for converting digital data bits into a serial analog stream at multiple frequencies for communication over a chip I/O connection. The track pulse generated on the transmitter side is serialized through the same path as the data, and demodulated through the same path in the de-serializer to provide synchronization with the data, without the need for complicated base band processing. | 10-29-2015 |
20150312070 | SCALABLE SERIAL/DE-SERIAL I/O FOR CHIP-TO-CHIP CONNECTION BASED ON MULTI-FREQUENCY QAM SCHEME - A serializer and de-serializer circuit which is particularly well-suited for use in communicating digital data from one integrated circuit (chip) to another for implementing chip-to-chip communications is presented. The circuits are scalable and utilize a multi-frequency quadrature amplitude modulation (QAM) mechanism for converting digital data bits from a parallel form into a serial analog stream for communication over a chip I/O connection. The serializer has multiple digital-to-analog converters (DACs) whose outputs are directed to QAM mixer inputs, within QAMs at multiple frequencies, whose outputs are summed into a single analog signal for communication over an I/O connection. The de-serializer amplifies the analog signal which is received by QAM mixers at different frequencies, whose outputs are low pass filtered and converted back to parallel digital data bits. | 10-29-2015 |
20150311529 | ELECTRONICALLY CONDUCTIVE POLYMER BINDER FOR LITHIUM-ION BATTERY ELECTRODE - A family of carboxylic acid groups containing fluorene/fluorenon copolymers is disclosed as binders of silicon particles in the fabrication of negative electrodes for use with lithium ion batteries. Triethyleneoxide side chains provide improved adhesion to materials such as, graphite, silicon, silicon alloy, tin, tin alloy. These binders enable the use of silicon as an electrode material as they significantly improve the cycle-ability of silicon by preventing electrode degradation over time. In particular, these polymers, which become conductive on first charge, bind to the silicon particles of the electrode, are flexible so as to better accommodate the expansion and contraction of the electrode during charge/discharge, and being conductive promote the flow battery current. | 10-29-2015 |
20150309253 | REDUCTION OF THERMO-OPTIC EFFECTS IN SILICON PHOTONICS - A method and system are described for reducing a thermo-optic effect in silicon photonics. In described embodiments, the system comprises a silicon photonic device with a silicon core that includes a cladding layer comprising titanium adjacent to the silicon core. In described embodiments, the method comprises providing a silicon core and depositing a cladding layer adjacent to the silicon photonic core, wherein the cladding layer comprises titanium. | 10-29-2015 |
20150309137 | MRI-BASED FAT DOUBLE BOND MAPPING - Techniques, apparatus and systems are described for using parameters including chain length, number of double bonds and number of double-double bonds of a complex, magnetic resonance imaging (MRI)-generated fat spectrum to determine the composition and properties of fat and to perform various diagnostic functions. In one aspect, a method using MRI to characterize fat includes acquiring a magnetic resonance (MR) image that includes MR data from a target, determining fat characterization parameters based on the acquired MR data, and using the determined fat characterization parameters to produce a relationship between regions of fat and/or water in the MR image. | 10-29-2015 |
20150308941 | SYSTEMS AND METHODS FOR PARTICLE CLASSIFICATION AND SORTING - A particle analysis system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet; and a particle analyzer configured to measure a size and a position of particles in the microchannel. A particle sorting system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; and a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet. | 10-29-2015 |
20150307855 | Producing 3-Hydroxycarboxylic Acid and Ketone Using Polyketide Synthases - The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone. | 10-29-2015 |
20150307519 | SMALL MOLECULES FOR RESTORING FUNCTION TO P53 CANCER MUTANTS - Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds. | 10-29-2015 |
20150307419 | METAL-ORGANIC FRAMEWORK FOR THE SEPARATION OF ALKANE ISOMERS - A metal organic framework Fe | 10-29-2015 |
20150306314 | Model-Based Personalization Scheme of an Artificial Pancreas for Type I Diabetes Applications - A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications. | 10-29-2015 |
20150306213 | HMGB1-DERIVED PEPTIDES ENHANCE IMMUNE RESPONSE TO ANTIGENS - The invention provides an immunostimulatory peptide containing the amino acid sequence SAFFLFCSE and uses thereof. | 10-29-2015 |
20150305914 | MULTI-LAYER CAST SYSTEMS AND METHODS - A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking. | 10-29-2015 |
20150304363 | HIDDEN IDENTIFIERS FOR DEMULTIPLEXING AND RESOLUTION ARCHITECTURE - A new and useful approach to binding network socket API using hidden identifiers, referred to by the acronym HIDRA (Hidden Identifiers for De-multiplexing and Resolution Architecture). HIDRA is the first solution that takes advantage of “hidden” identifiers to be used in hosts. HIDRA has three main components that integrate together: a protocol-agnostic API and stack; upgraded name-resolution and service-discovery functions; and transport-layer modifications. The hidden identifiers are de-multiplexed into open identifiers in lower protocol layers and open identifiers are resolved back into hidden identifiers in lower protocol layers for use by the application. | 10-22-2015 |
20150303382 | Bay-Annulated Indigo (BAI) As An Excellent Electron Accepting Building Block for High Performance Organic Semiconductors - A novel electron acceptor based on bay-annulated indigo (BAI) was synthesized and used for the preparation of a series of high performance donor-acceptor small molecules and polymers. The resulting materials possess low-lying LUMO energy level and small HOMO-LUMO gaps, while their films exhibited high crystallinity upon thermal treatment, commensurate with high field effect mobilities and ambipolar transfer characteristics. | 10-22-2015 |
20150299852 | GRAPHENE BASED ELECTRODES AND APPLICATIONS - Methods of fabricating a graphene film are disclosed. An example method can include providing a substrate, heating the substrate between about 600° C. and about 1100° C. in a chamber, and introducing a carbon source into the chamber at a temperature between about 600° C. and about 1100° C. for about 10 seconds to about 1 minute. The method can further include cooling the substrate to about room temperature to form the graphene film Methods of fabricating pillared graphene nano structures and graphene based devices are also provided. | 10-22-2015 |
20150299343 | POLYMER PLASTICIZING AGENTS THAT PRODUCE POLYMERS THAT DO NOT RELEASE ENDOCRINE DISRUPTING COMPOUNDS - Disclosed are novel phthalate compounds and a simple and economical route to covalently attach a phthalate ester mimic to PVC is described, allowing plasticization of PVC without the danger of Endocrine Disruption Chemicals leaching from the polymer matrix. An azide-alkyne Husigen cycloaddition (in the absences of copper catalyst) using dialkyl acetylenedicarboxylates allows this cycloaddition to occur under very mild thermal conditions. | 10-22-2015 |
20150297106 | METHODS OF DECODING SPEECH FROM BRAIN ACTIVITY DATA AND DEVICES FOR PRACTICING THE SAME - The present disclosure provides methods of decoding speech from brain activity data. Aspects of the methods include receiving brain speech activity data from a subject, and processing the brain speech activity data to output speech feature data. Also provided are devices and systems for practicing the subject methods. | 10-22-2015 |
20150295226 | LOW-TEMPERATURE CONTINUOUS PROCESS TO DERIVE SIZE-CONTROLLED LITHIUM ION ANODES AND CATHODES - The disclosure relates to a process to synthesize nanostructures of a uniform size distribution and/or morphology, nanostructures resulting therefrom, and the use of the nanostructures in energy storage devices. | 10-15-2015 |
20150294960 | INTERDIGITATED MULTIPLE PIXEL ARRAYS OF LIGHT-EMITTING DEVICES - The present invention discloses a plurality of interdigitated pixels arranged in an array, having a very low series-resistance with improved current spreading and improved heat-sinking Each pixel is a square with sides of dimension l. The series resistance is minimized by increasing the perimeter of an active region for the pixels. The series resistance is also minimized by shrinking the space between a mesa and n-contact for each pixel. | 10-15-2015 |
20150290209 | FIRMOCIDIN, AN ANTIMICROBIAL MOLECULE PRODUCED BY STAPHYLOCOCCUS EPIDERMIDIS - The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof. | 10-15-2015 |
20150290150 | ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF - The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. | 10-15-2015 |
20150290149 | ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF - The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. | 10-15-2015 |
20150289804 | NETWORKED SENSOR SYSTEMS FOR REMOTE PATIENT MONITORING - A remote patient monitoring system which is particularly well-suited for clinical out of center sleep testing (clinical OCST). Sensor nodes are grouped for wearing on the head, chest, and lower body of the patient. Sensor nodes wirelessly communicate sensor data to a nearby gateway, which communicates this data over a network (e.g., Internet) to one or more servers. The server(s) analyzes the sensor data for usage assurance, and to discern patient sleep patterns and characteristics. Guidance messages are generated by the system based on the analysis. Interfaces are provided to allow the patient to access their own information, and healthcare providers to access information collected regarding their patients. | 10-15-2015 |
20150288146 | VERTICAL CAVITY SURFACE EMITTING LASERS WITH SILICON-ON-INSULATOR HIGH CONTRAST GRATING - A surface emitting laser apparatus is formed using a patterned silicon-on-insulator (SOI)-like substrate which is patterned with a buried sub-wavelength high contrast grating and adapted for bonding of a half-VCSEL device containing at least an active region and an upper mirror, to create a VCSEL. The wavelength of the VCSEL, or any individual VCSEL within an array of VCSEL devices, can be set in response to changing HCG characteristics of the lower mirror in the SOI-like substrate, or in the region above the lower mirror within the half-VCSEL. The inventive VCSEL device and fabrication method are beneficial for a number of application and devices. | 10-08-2015 |
20150286006 | HIGH EFFICIENCY VERTICAL OPTICAL COUPLER USING SUB-WAVELENGTH HIGH CONTRAST GRATING - A vertical optical coupler which redirects light transmission in response to the interaction between a sub-wavelength high contrast grating (HCG) having a plurality of spaced apart segments of grating material which is optically coupled to a waveguide. For a selected set of material, grating geometry, gaps and spacing, the light directed at a normal incidence into the optical coupler is angularly displaced in traveling in the optical waveguide, while light directed along the optical waveguide is angularly displaced in being output at normal incidence from the optical coupler. The coupler is integrated into a number of device embodiments, including: a coupler between angularly displaced waveguides, lasers, light emitting diodes (LEDs) and solar cells. | 10-08-2015 |
20150285717 | SYSTEMS, METHODS AND COMPONENTS FOR ISOLATING CELLS FROM A FLUID SAMPLE - A system for isolating preselected cell types from a fluid sample that includes a plurality of cell types includes a cell-capture fluidic chip, and a chip holder configured to receive the cell-capture fluidic chip and to maintain the cell-capture fluidic chip with a substantially fluid-tight seal while in operation. The chip holder is further configured to release the cell-capture fluidic chip to be removed from the chip holder for further processing. The cell-capture fluidic chip includes a substrate, a laser micro-dissection membrane disposed on the substrate, and a channel-defining layer disposed on the laser micro-dissection membrane. The laser micro-dissection membrane has a surface adapted to capture preselected cell types preferentially over other cell types of the plurality of cell types. The channel-defining layer is removable from the laser micro-dissection membrane for further processing of the cell-capture fluidic chip. | 10-08-2015 |
20150283100 | ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF - The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. | 10-08-2015 |
20150280034 | SEMICONDUCTOR INFRARED PHOTODETECTORS - A semiconductor device capable of enhanced sub-bandgap photon absorption and detection is described. This semiconductor device includes a p-n junction structure formed of a semiconductor material, wherein the p-n junction structure is configured such that at least one side of the p-n junction (p-side or n-side) is spatially confined in at least one dimension of the device (e.g., the direction perpendicular to the p-n junction interface). Moreover, at least one side of the p-n junction (p-side or n-side) is heavily doped. The semiconductor device also includes electrical contacts formed on a semiconductor substrate to apply an electrical bias to the p-n junction to activate the optical response at target optical wavelength corresponds to an energy substantially equal to or less than the energy band-gap of the first semiconductor material. In particular embodiments, the semiconductor material is silicon. | 10-01-2015 |
20150276712 | GFP MUTAGENESIS AMPLIFICATION: USE OF A FLUORESCENCE-ANTIBIOTIC RESISTANCE FUSION DUAL REPORTER CONSTRUCT TO PROVIDE QUANTITATIVE AND HIGHLY SENSITIVE DETECTION OF MUTATIONS - A reversion mutation assay that is unique in providing a quantitative readout for mutagenesis. This assay is based on the creation of a functional GFP-β-lactamase fusion protein as a reporter providing both antibiotic resistance and fluorescence. | 10-01-2015 |
20150276610 | REAL-TIME, SINGLE-STEP BIOASSAY USING NANOPLASMONIC RESONATOR WITH ULTRA-HIGH SENSITIVITY - A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes. | 10-01-2015 |
20150276548 | CONDITION MONITORING AND ANALYTICS FOR MACHINES - A method for monitoring a condition of an actuator for a machine using a closed loop Hammerstein model structure is disclosed. The method includes receiving measured data for the machine and determining an actuator command associated with the measured data. The method also includes identifying a current static nonlinearity using one or more linear regression techniques, where the static nonlinearity is modeled between a known actuator and a linear plant of the machine. The method further includes determining whether the condition of the actuator has changed by comparing a resultant from identifying the current static nonlinearity with information of the known actuator. | 10-01-2015 |
20150275279 | RNA-BASED, AMPLIFICATION-FREE, ORGANISM IDENTIFICATION USING NANO-ENABLED ELECTRONIC DETECTION - A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system. | 10-01-2015 |
20150275077 | Novel Compositions for Cooling Materials Exposed to the Sun - The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. | 10-01-2015 |
20150273755 | BACTERICIDAL SURFACE PATTERNS - The invention relates to imparting surfaces with nanometer sized structures that provide bactericidal properties to the surface and devices. In one embodiment, the present invention provides a bactericidal surface with nanometer sized pillars created by imprinting a softened polymer surface with a mold. In another embodiment, the nanometer sized pillars are part of a medical device with antibacterial properties. | 10-01-2015 |
20150273404 | Polyaniline Membranes, Uses, and Methods Thereto - Disclosed herein are methods of increasing the hydrophilicity of a membrane. Membranes comprising polyaniline or co-polymer thereof and one or more gel inhibiting agents are treated with one or more hydrophilicity restoration agents, thereby increasing the hydrophilicity of a membrane. Also disclosed are membranes produced by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-01-2015 |
20150271964 | Almond tree named 'Kester' - A new almond variety ( | 09-24-2015 |
20150268359 | Novel Lanthanide Doped Barium Mixed Halide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising an optionally lanthanide-doped barium mixed halide, useful for detecting nuclear material. | 09-24-2015 |