SAPPORO MEDICAL UNIVERSITY Patent applications |
Patent application number | Title | Published |
20150031033 | METHOD AND KIT FOR DETECTION OF CANCER, AND THERAPEUTIC AGENT FOR CANCER - The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c. | 01-29-2015 |
20140234335 | METHOD AND REAGENT FOR DIAGNOSIS AND/OR EVAULATION OF PROGRESSION OF GRAFT-VERSUS-HOST DISEASE - Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody. | 08-21-2014 |
20140057845 | COMPOSITION FOR TREATING, IMPROVING, OR PREVENTING PAIN - In order to provide a composition for treating, improving, or preventing pain, it has been found out that a metallothionein protein is expressed in a normal peripheral nerve, and that the expression is not observed in a peripheral nerve producing pain. Moreover, it has been found out that administering metallothionein to rats having neuropathic pain suppresses the pain in the rats. | 02-27-2014 |
20140044686 | MOLECULAR MARKER FOR CANCER STEM CELL - A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker. | 02-13-2014 |
20130323763 | METHOD FOR DIAGNOSING ACUTE LUNG INJURY - The present invention provides a useful examination method and diagnostic reagent, which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. Specifically, the present invention provides a method of determining whether or not a test subject is affected with acute lung injury, which comprises quantifying heat shock protein 47 in a biological sample derived from the test subject. | 12-05-2013 |
20130302838 | BIOMARKER FOR AMYLOID-B-RELATED NEUROLOGICAL DISORDERS - A novel biomarker for diagnosing amyloid β-related neuropathy such as Alzheimer's disease is provided. Disclosed is a method for diagnosing Alzheimer's disease comprising measuring the level of a MFG-E8 protein in a blood, serum or plasma sample obtained from a human or animal subject, wherein the measured value is used as a marker for diagnosis of Alzheimer's disease. The MFG-E8 protein is found to bind to phosphatidylserine in a Ca | 11-14-2013 |
20130267965 | LIGATOR AND LIGATION METHOD - A ligator for ligating body duct(s), said ligator enabling quick, easy and damage-free repetition of ligation and release of one or more body ducts in a body cavity through an operation outside the body cavity, and having an excellent performance of blocking the flow of a body fluid such as blood or lymph in a body duct. In an abdominal surgery, the ligator can be provided at such a position as not disturbing the surgery per se or hindering the vision during the surgery, while leaving the back-end thereof outside the body cavity, and can be operated outside the body cavity. In an endoscopic surgery, the ligator can be inserted from an opening that is a surgical wound while leaving the back-end thereof outside the body cavity, and can be operated outside the body cavity. | 10-10-2013 |
20130267430 | METHOD AND REAGENT FOR DIAGNOSIS AND/OR EVALUATION OF PROGRESSION OF GRAFT-VERSUS-HOST DISEASE - Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody. | 10-10-2013 |
20130243736 | REPLACEMENT OF BONE MARROW NICHE CELLS FOR TREATMENT OF VARIOUS DISEASES - In vitro 2-dimensional co-culture systems of LT-HSCs and osteoblastic niche cells and methods of establishing them are provided. For example, in certain aspects methods of screening people suffering from a disorder caused by dysfunction of osteoblastic niche cells, using said co-culture systems are described. In further aspects, methods for screening a candidate substance for treatment of a disorder caused by dysfunction of osteoblastic niche cells are provided. The present invention also concerns methods and therapeutic compositions of treating a patient suffering from a disorder caused by dysfunction of osteoblastic niche cells. | 09-19-2013 |
20130130382 | AUTOSERUM-CONTAINING BONE MARROW CELL CULTURE SYSTEM, AUTOSERUM-CONTAINING BONE MARROW CELL CULTURE METHOD, AND METHOD FOR PRODUCING MEDICINAL COMPOSITION COMPRISING AUTOSERUM-CONTAINING CULTURED BONE MARROW CELLS AS ACTIVE INGREDIENT - To provide an autoserum-containing bone marrow cell culture system, whereby bone marrow cells, which are collected from a subject without using an anticoagulant, are subjected to an anticoagulation treatment using a medium in a liquid-tight state, cultured and then further cultured using the serum of said subject which is prepared in a liquid-tight state; an autoserum-containing bone marrow cell culture method; and a method for producing a medicinal composition which comprises, as the active ingredient, autoserum-containing cultured bone marrow cells. [Solution] An autoserum-containing bone marrow cell culture system for culturing bone marrow cells, which are collected from a subject without using an anticoagulant, using the serum of said subject, said system comprising a bone marrow cell suspension-storing device, a collected blood-storing device, an autoserum-acquiring device, and a bone marrow cell-culturing device. | 05-23-2013 |
20120264120 | SPECIMEN FOR DETECTING INFILTRATIVE LARGE INTESTINE TUMORS - An object of the present invention is to provide a method for non-invasively diagnosing invasiveness or degree of invasion of colorectal tumors. | 10-18-2012 |
20120255853 | Method for Producing Superoxide, Method for Evaluating Superoxide Scavenging Ability, Device for Producing Superoxide, and Device for Evaluating Superoxide Scavenging Ability - A method for easily and stably producing a superoxide by selectively generating the superoxide or a radical containing the superoxide at a high purity; a method for easily evaluating the superoxide scavenging ability of a subject sample; a device for easily and stably producing a superoxide by selectively generating the superoxide or a radical containing the superoxide at a high purity; and a device for easily evaluating the superoxide scavenging ability of a subject sample are provided. The method for producing a superoxide includes: a step (a) for preparing a solution for determination; a step (b) for forming a spin adduct/radical for determination; a step (c) for acquiring a spectrum for determination; a step (d) for determining similarity; a step (e) for acquiring flavin concentration; a step (f) for preparing a starting material solution; and a step (g) for generation. | 10-11-2012 |
20120237518 | ANTI-TROP-2 ANTIBODY - The present invention relates to a monoclonal antibody or an antibody fragment thereof, which binds to the extracellular region of human Trop-2 with high affinity and exhibits high ADCC activity and high antitumor activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent or a diagnostic agent using the antibody fragment thereof. | 09-20-2012 |
20120021063 | CROSSLINKED MATERIAL COMPRISING ELASTIN AND COLLAGEN, AND USE THEREOF - To provide a collagen/elastin crosslinked material capable of satisfactorily corresponding to various uses such as medical materials including an artificial dermis and scaffolding materials for cell culture. The collagen/elastin crosslinked material is obtained by crosslinking a fish-derived collagen and a fish-derived elastin, and is fully capable of corresponding to various uses such as medical materials including an artificial dermis and scaffold material for cell culture. | 01-26-2012 |
20110262358 | MOLECULAR MARKER FOR CANCER STEM CELL - A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker. | 10-27-2011 |
20110158908 | CYCLOSPORIN A-BINDING PROTEIN - Disclosed are: a composition and a method for the diagnosis and/or the treatment of a CSABP-related disease, the regulation of the proliferation of an RNA virus and the regulation of an RNA-metabolizing system, which targets a cyclosporin A-binding protein (CSABP); a method for the screening of a component that targets a CSABP; a composition and a method for the detection/inhibition of CsA, NS5B or cyclosphilin B by utilizing a CSABP; a promoter for a CSABP; a method for the screening of a substance capable of regulating the expression of a CSABP by utilizing the promoter; and a method for the determination of the occurrence or clinical stage of a CSABP-related disease. | 06-30-2011 |
20110130341 | METHOD AND KIT FOR DETECTION OF CANCER, AND THERAPEUTIC AGENT FOR CANCER - The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c. | 06-02-2011 |
20110105589 | APOPTOSIS INDUCER - This invention relates to an agent, a composition and a product comprising at least one apoptosis-inducing substance, and at least one substance which inhibits expression and/or activity of an apoptosis-inhibiting substance; a method for inducing apoptosis or for treating a proliferative disease using one or more of them; a nucleic acid construct comprising a nucleic acid molecule encoding a protein to be expressed and a nucleic acid molecule which inhibits expression of an undesired protein; and a method for expressing a desired protein in a cell while inhibiting the expression of an undesired protein. | 05-05-2011 |
20100254953 | CELL GROWTH METHOD AND PHARMACEUTICAL PREPARATION FOR TISSUE REPAIR AND REGENERATION - The present invention relates to a method for growing, rapidly and massively ex vivo, cells collected from a living subject to provide a safe and effective pharmaceutical preparation for biological tissue repair/regeneration. Specifically, the present invention relates to a method for growing cells in a sample collected from a living subject by culturing the cells in a medium containing allogeneic (including autogenic) serum. Preferably the allogeneic serum has been determined as being negative for a serum tumor marker and/or an infectious factors, and the amount of the anticoagulant (e.g., heparin, a heparin derivative, or a salt thereof) added to the collected sample is less than 5 U/mL with respect to the volume of the sample or the amount of the anticoagulant in the medium at the start of culture is less than 0.5 U/mL. The present invention further relates to use of the method. | 10-07-2010 |
20100249902 | STENT AND TREATMENT DEVICE FOR TUBULAR ORGAN - The present invention provides a stent and tubular organ treatment device that can flexibly deform according to a curved portion of a tubular organ, contracts less in the longitudinal direction during insertion, and is easy to handle. A stent ( | 09-30-2010 |
20100174354 | STENT PLACEMENT DEVICE AND STENT PLACEMENT METHOD - A stent placement device and a stent placement method, despite a simple structure thereof, can surely and readily deploy a stent by placing a distal end thereof prior to a proximal end thereof, having favorably low invasiveness, and smoothly insert and arrange the stent into a desired position, without damaging an internal lumen inner wall. A placement device | 07-08-2010 |
20100068702 | Method for Detecting Disease-Related Marker Using Gastric Mucosal Lavage Fluid - The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less invasively, highly sensitively and highly accurately. | 03-18-2010 |
20100016730 | EXAMINATION SYSTEM, REHABILITATION SYSTEM, AND VISUAL INFORMATION DISPLAY SYSTEM - In an examination system including a head mounted display having image pickup devices such as CCDs provided therein and a computer, coordinates of an image to be displayed in the head mounted display can be set object- or body-centered. An image captured by the image pickup device is supplied to the computer where it will be processed in a predetermined manner for display in the head mounted display. | 01-21-2010 |
20090281184 | PHARMACEUTICAL FOR PREVENTION AND TREATMENT OF OPHTHALMIC DISEASE INDUCED BY IN-CREASE IN VASOPERMEABILITY - A medicament for preventive and/or therapeutic treatment of an ocular disease resulting from vascular hyperpermeability, for example diabetic retinopathy or age-related macular degeneration, which comprises as an active ingredient a retinoid such as all trans retinoic acid or 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. | 11-12-2009 |
20090141979 | IMAGE PROCESSING DEVICE AND RECORDING MEDIUM STORING IMAGE PROCESSING PROGRAM - An inspection apparatus includes an imaging device and an image processing device. The imaging device photographs a specimen and outputs a color image of the specimen to the image processing device. The image processing device subjects the color image of the specimen to negative-positive reversal. After detecting a mode value of the hue the color image having been subjected to negative-positive reversal, the image processing device changes the hue of the color image in accordance with a difference between a boundary value of two predefined hues and the detected mode value. In accordance with the change of the hue, a plurality of target pixels different in the saturation is extracted and the saturation and the intensity of each pixel are changed, or the gradation of each pixel is converted so that the plurality of target pixels becomes most distant from one another in a color space. | 06-04-2009 |
20090110273 | Image Processing Device and Image Processing Program - An inspection apparatus includes an imaging device and an image processing device. The imaging device photographs a specimen and outputs a color image of the specimen to the image processing device. The image processing device subjects the color image of the specimen to negative-positive reversal. After detecting a mode value of the hue of the color image having been subjected to negative-positive reversal, the image processing device changes the hue of the color image in accordance with a difference between a boundary value of two predefined hues and the detected mode value. In accordance with the change of the hue, a plurality of target pixels different in the saturation is extracted and the saturation and the intensity of each pixel are changed, or the gradation of each pixel is converted so that the plurality of target pixels becomes most distant from one another in a color space. | 04-30-2009 |