OHIO UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160137585 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION - Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research. | 05-19-2016 |
20160035247 | VISUAL FEEDBACK GENERATION IN TRACING A PATTERN - Systems and methods include generating visual feedback from a traced pattern that is completed by an individual using a multi-touch device. Embodiments of the present disclosure relate to displaying a previously generated pattern by a user interface of the multi-touch device to the individual for the individual to trace. The traced pattern generated from continuously tracing the previously generated pattern by the individual from an initial point on the previously generated pattern to an end point on the previously generated pattern is received via the user interface of the multi-touch device. Visual feedback is generated via the user interface that translates motion-based behavior data associated with the traced pattern to a visible depiction of the motion-based behavior data. | 02-04-2016 |
20150351608 | METHOD AND DEVICE FOR EVALUATING A COLONOSCOPY PROCEDURE - A method and device for evaluating a colonoscopy procedure includes an endoscope ( | 12-10-2015 |
20150293116 | Ionization of Chemicals in Mixture at Low pH by Ambient Ionization/Mass Spectrometry - A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent ( | 10-15-2015 |
20150125604 | Method of Producing Graphene - Graphene can be produced from the byproducts formed during electrolysis of coal. These byproducts may be electrolyzed coal particles, gelatinous film formed on the electrolyzed coal particles, or the electrolyzed coal particles together with the gelatinous film. The electrolyzed coal byproduct is deposited as a thin layer onto a surface, or carrier substrate | 05-07-2015 |
20140349266 | ACTIVE COLONOSCOPY TRAINING MODEL AND METHOD OF USING THE SAME - An active colonoscopy training model ( | 11-27-2014 |
20140333524 | MOTION-BASED IDENTITY AUTHENTICATION OF AN INDIVIDUAL WITH A COMMUNICATIONS DEVICE - Systems, methods and computer storage mediums securely authenticate an identity of an individual based on a pattern that is traced by the individual. Embodiments of the present disclosure relate to prompting an individual with a pattern to trace when attempting to authenticate the identity of the individual during an identity authentication session. Motion-based behavior data that is generated by motions executed by the individual as the individual traces the pattern is captured via a motion-capturing sensor. The motion-based behavior data is unique to the individual and has a low likelihood of being duplicated by an unauthorized individual attempting to fraudulently pose as the individual. The captured motion-based behavior data is compared to previously captured motion-based behavior data from previous traces of the pattern completed by the individual. The identity of the individual is authenticated when the motion-based behavior data is within a threshold of the previously captured motion-based behavior data. | 11-13-2014 |
20140286374 | TEST SYSTEM AND METHOD FOR DETERMINING THERMAL EFFECTS OF TISSUE ABLATION ON AN EX VIVO TISSUE - A test system and method for determining thermal effects of tissue ablation on an ex vivo tissue includes a power generator, a grounding patch, and a material block configured to emulate an electrical property of a patient. The power generator electrically connects to an electrode to generate an electrical current in the electrode. The grounding patch electrically connects to the power generator, and the material block electrically connects to the grounding patch. Furthermore, the material block includes an ex vivo tissue patch configured to emulate an in vivo tissue of the patient. As such, selectively engaging the electrode to the ex vivo tissue patch electrically connects the electrode to the grounding patch through the material block for electrocauterizing the ex vivo tissue patch. | 09-25-2014 |
20140257036 | Method And Device For Detecting Thermal Effects Of Tissue Ablation On A Tissue Of A Patient - A method and device for detecting thermal effects of tissue ablation on a tissue of a patient includes an endoscope, a biopsy forceps, and an electrical measurement circuit. The method includes measuring a first value of an electrical property of the tissue and removing at least a portion of the tissue with the hot biopsy forceps. The method also includes measuring a second value of the electrical property of the remaining tissue. Accordingly, the electrical measurement circuit is configured to correlate the difference between the first and second values to a depth of ablation. | 09-11-2014 |
20140194335 | COMPOSITIONS AND METHODS FOR TREATING BIOFILMS - Compositions and methods for treating biofilm formation and growth on a substrate are provided. The composition comprises 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The method comprises contacting the substrate with 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The compositions and methods are effective for preventing, reducing or eliminating biofilm formation or biofilm growth or both, as well as eradicating established, recalcitrant biofilms, particularly biofilms comprising sulfate reducing bacteria that are known to cause microbiologically influenced corrosion, biofouling, or both. | 07-10-2014 |
20140190289 | MOTORIZED DRIVE SYSTEM AND METHOD FOR ARTICULATING A JOINT - A motorized drive system and method for articulating an articulated joint having a motor and an elastic cable. The elastic cable is operatively connected to both the motor and the articulated joint such that the motor articulates the joint via the elastic cable. In addition, the elastic cable is adapted to be sufficiently elastic such that the motorized drive system is configured to use one motor for each degree of freedom through which the articulated joint moves. | 07-10-2014 |
20140186824 | DYNAMIC BIOCHEMICAL TISSUE ANALYSIS ASSAYS AND COMPOSITIONS - Described herein is a method, and compositions useful with the method, of analyzing a tissue from a subject. The method includes contacting a probe conjugate ( | 07-03-2014 |
20140186806 | PUPILLOMETRIC ASSESSMENT OF LANGUAGE COMPREHENSION - The present invention is a method for assessing a patient's linguistic comprehension using a pupil response system comprising at least one pupillometer configured to measure the patient's pupil responses. The method includes (a) providing the patient with a list of verbal stimuli comprising at least two sets of verbal stimuli, each set of verbal stimuli comprising one or more verbal stimuli; wherein the two sets of the verbal stimuli differ substantially from each other in terms of the difficulty level; (b) presenting to the patient one verbal stimulus at a time from the list of verbal stimuli; (c) measuring and recording the patient's pupil response data for a period of time ranging from 200 milliseconds to 10 seconds during the presentation of each stimulus; and (d) analyzing the pupil response data to assess the patient's linguistic comprehension. | 07-03-2014 |
20140175002 | EXFILTRATION APPARATUS - An exfiltration apparatus for removing contaminants from a fluid includes a housing, a filter portion positioned within the housing, and a particulate collecting member. The housing defines a fluid flow path extending from a fluid inlet disposed on a first side of the housing to a fluid outlet disposed on a second side of the housing. The particulate collecting member is disposed within the housing between the fluid inlet and the filter portion. The particulate collecting member includes a recessed particulate collecting portion proximate the filter portion and a raised apertured portion proximate the fluid inlet. Fluid flowing along the fluid flow path passes through the particulate collecting member and through the filter portion before exiting through the fluid outlet. | 06-26-2014 |
20140158548 | ELECTROLYTIC CELLS AND METHODS FOR THE PRODUCTION OF AMMONIA AND HYDROGEN - A method using an electrolytic cell to electrolyze urea to produce at least one of H | 06-12-2014 |
20140147921 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 05-29-2014 |
20140136110 | WAKE TURBULENCE ANALYZER FOR REAL-TIME VISUALIZATION, DETECTION, AND AVOIDANCE - A computer method for determining potential wake turbulence by a first aircraft from wake generated by a second aircraft. The computer method includes receiving a signal generated by the second aircraft at the first aircraft and transforming the signal to a first wake turbulence boundary that represents the wake generated by the second aircraft. An intersection volume, which is representative of a zone of dangerous turbulence interactions, is selected for the first aircraft. Based on a determination of intersection between the first wake turbulence boundary and the intersection volume, issuing a warning flag if an intersection exists or continue generating the first wake turbulence boundary and determining whether interactions exist. | 05-15-2014 |
20140116138 | DEVICE AND METHOD FOR MONITORING INTERACTION BETWEEN A FLUID AND A WALL - A sensor device and method for monitoring interaction between a fluid and a wall includes includes a mechanical oscillator, a housing, and mechanical response sensing system. The mechanical oscillator includes a floating member formed from a first material configured to be susceptible to the fluid and a support member formed from a second material resistant to the fluid. The mechanical oscillator is affixed within the housing that is adaptably fastened to the structural component such that the floating member contacts the fluid. The mechanical response sensing system is configured to measure a mechanical characteristic of the combined floating member and the support member. The mechanical characteristic is configured to be indicative of the interaction between the fluid and the wall. | 05-01-2014 |
20140091809 | SECURITY SYSTEM FOR UNDERGROUND CONDUIT - In a method for detecting disruptions proximate to an underground conduit, at least one signal carrying cable is positioned along a length of the conduit and between the conduit and a ground surface. At least one cable engaging member is connected to spaced apart locations on the at least one signal carrying cable to extend laterally outward of the at least one signal carrying cable. Each of the at least one cable engaging members is configured to transmit a force to the at least one signal carrying cable when impacted by an external force. A monitoring signal is provided to the at least one signal carrying cable, and a reflected monitoring signal is received in response to the supplied monitoring signal. One or more properties of the reflected monitoring signal are compared to one or more corresponding properties of a predicted reflected monitoring signal. An alert is initiated when the one or more properties of the reflected monitoring signal differ from the one or more properties of the predicted reflected monitoring signal by a predetermined amount. | 04-03-2014 |
20140048424 | METHODS AND DEVICES FOR THE DETECTION OF BIOFILMS - Methods and devices for the detection of corrosive biofilms and microbiologically influenced (MIC) corrosion rates are based upon the electrogenicity of the biofilms. The device may comprise a passive sensor having at least one first electrode, at least one second electrode, and an external circuit for electrically connecting the first electrode to the second electrode. At least one of the first electrode and the second electrode is capable of being at least partially coated by a biofilm. A sustainable electrical characteristic, such as voltage and current, generated when the first electrode and the second electrode are electrically connected and exposed to at least one medium indicates that the biofilm partially coating at least one of the first electrode and the second electrode is electrogenic, and thus corrosive. Special electrode and sensor designs are needed for the implementation of online and offline biofilm sensors. | 02-20-2014 |
20140027301 | SELECTIVE REDUCTIVE ELECTROWINNING APPARATUS AND METHOD - A method and electrochemical cell for recovery of metals is provided, where the electrochemical cell includes an anode disposed in an anodic chamber, a cathode disposed in a cathodic chamber, an ion-conducting separator disposed between the anode and the cathode to physically separate the anodic and cathodic chambers, a basic pH anolyte containing a sacrificial reductant disposed within the anodic chamber, an acidic pH catholyte containing metal ions disposed within the cathodic chamber, and an electrical connection between the anode and the cathode. The method includes applying a voltage or an electrical current to an electrolytic cell across the cathode and the anode and is sufficient to reduce the metal ions to form an elemental metal species at the cathode, and to oxidize the sacrificial reductant at the anode. | 01-30-2014 |
20140024806 | Glycoproteins Produced in Plants and Methods of Their Use - Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed. | 01-23-2014 |
20130293421 | TERRESTRIAL POSITION AND TIMING SYSTEM - A terrestrial positioning and timing system (TPTS) comprising a ground segment and user segment is disclosed that is comprised of a spread-spectrum based range and bearing reference signal, with respect to a reference time, transmitted by an antenna over a broad region of space; and a spread-spectrum based bearing variable signal with bearing specific modulation referenced to a reference time, transmitted using a scanning antenna over a spatial region of space that is more narrow than the spread-spectrum based range and bearing reference signal transmission spatial area. Various embodiments enable the TPTS station and user to support various position, velocity or time services. Most notably, an embodiment with a single TPTS station, active interrogation/transponder reply, and data delivery subsystem can provide a position, velocity, and time solution for the user. Additional embodiments disclosed provide varying levels of user solutions to include bearing, position, velocity, or time. | 11-07-2013 |
20130237503 | PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN - The present invention provides pharmaceutical compositions comprising phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV). In some embodiments, such compositions may be useful for treating cancers, including cisplatin- and carboplatin-resistant cancers. The provided phosphaplatin complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum agents that have a different molecular target than those in the art. | 09-12-2013 |
20130236568 | PHOSPHAPLATINS HAVING ANTI-ANGIOGENIC, ANTI-METASTATIC, AND PRO-APOPTOTIC PROPERTIES AND USES THEREOF - Provided are compositions and uses thereof in methods of inhibiting angiogenesis, metastasis, or both, wherein said compositions comprise phosphaplatins such as pyrodach-4. In some embodiments, provided are compositions and uses thereof in methods of treating sensitive and resistant cancers. | 09-12-2013 |
20130180166 | HYBRID SYSTEM FOR ENHANCING ALGAL GROWTH USING VERTICAL MEMBRANES - A method for enhancing gas-to-liquid transfer rate and algal growth using vertical membranes suspended over a pond, wherein the membranes are formed of fibers. An aqueous solution is applied to the top edges of the membranes through a series of headers. The membranes are exposed to a stream of gas containing soluble gas species as the aqueous solution migrates downwardly through the membranes by virtue of gravity-assisted capillary action. The aqueous solution collects the soluble gases from the gas stream, thus promoting the growth of photosynthetic organisms on the membranes and in the pond. The membranes facilitate a gradual introduction of the aqueous solution into the pond at a preferred rate of about 1.3 gallons per minute per linear foot of membrane for optimizing the transfer soluble species from gaseous phase to aqueous phase without rapidly acidifying the pond and harming the phototrophic organisms. | 07-18-2013 |
20130131815 | MECHANICAL CAPSTAN AMPLIFIER - A mechanical capstan amplifier. The mechanical capstan amplifier ( | 05-23-2013 |
20130112804 | Multi-Modal Vehicle - A multi-modal vehicle (“MMV”) | 05-09-2013 |
20130104073 | IMMERSIVE VIDEO INTELLIGENCE NETWORK - A method of providing a navigable environment of an indoor space. The indoor space includes a plurality of rooms | 04-25-2013 |
20130064902 | PHOSPHAPLATINS AND THEIR USE FOR TREATMENT OF CANCERS - Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed. | 03-14-2013 |
20130040822 | Engineering of an Ultra-Thin Molecular Superconductor by Charge Transfer - A method of forming a superconductive device of a single layer of (BETS) | 02-14-2013 |
20130037424 | ELECTROLYTIC CELLS AND METHODS FOR THE PRODUCTION OF AMMONIA AND HYDROGEN - A method using an electrolytic cell to electrolyze urea to produce at least one of H | 02-14-2013 |
20120325682 | LAYERED ELECTROCATALYST FOR OXIDATION OF AMMONIA AND ETHANOL - A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst. | 12-27-2012 |
20120312695 | COMPOSITE MEMBRANE FOR POLYMER ELECTROLYTE MEMBRANE FUEL CELL - The present invention relates generally to conducting polymer composites for use in electrochemical applications and electrolysis applications, and methods of making the same. A composite material is provided that includes a conducting polymer; and a silsesquioxane compound. The composite material is used to prepare ion conducting membranes and membrane electrode assemblies (MEA). | 12-13-2012 |
20120296266 | Systems and Methods For Promoting Wound Healing - In various embodiments, provided are topical gas delivery systems and methods for promoting wound healing. A provided gas delivery system comprises a gas reservoir comprising at least one chamber adapted to contain one or more therapeutic gases selected from NO, CO, O | 11-22-2012 |
20120283332 | TRANSDERMAL DELIVERY OF METFORMIN - Provided is a transdermal metformin that is an effective alternative treatment modality in patients with insulin resistance. Transdermal metformin can be used in conditions where oral metformin is indicated such as Type 2 diabetes mellitus, pre-diabetes, polycystic ovarian syndrome, and other known diabetes associated disorders. One advantage of using transdermal metformin is its ability to bypass the gastrointestinal system. This allows the drug to not have the gastrointestinal side-effects associated with oral metformin. A surprising advantage of using transdermal metformin in accordance with this disclosure is a 90% decrease in dosage from the oral preparation. | 11-08-2012 |
20120227588 | CARBON FIBER COMPOSITE DISCHARGE ELECTRODE - A discharge electrode using carbon fibers, nanofibers and/or nanotubes to generate the corona discharge. The invention contemplates carbon fiber electrodes with or without a polymer matrix to form a composite, and a supporting configuration in which the fibers are wrapped helically around a supporting rod that extends along the length of the electrode. Another supporting configuration includes the fibers stretched across the gas flow path. Yet another supporting configuration includes mounting the fibers along the length of the support rod substantially parallel to the rod. | 09-13-2012 |
20120127030 | TIGHT OPTICAL INTEGRATION (TOI) OF IMAGES WITH GPS RANGE MEASUREMENTS - A method of determining the position of a user in 3D space is disclosed. In one example, the method comprises utilizing range measurements from one or more GPS satellite vehicles, angular information of a camera located at the user position, and a camera image associated with one or more known markers. The method further comprises determining the angular information of the camera by determining a direction cosine matrix between a camera frame of reference and an earth frame of reference, and designating unit vectors that individually extend from a position within the camera image associated with one of the known markers through the camera focal point to the respective known marker The method also includes integrating into an ordinary least squares matrix, the GPS range measurements, the angular information of the camera, and the unit vectors, and calculating the user position by solving the ordinary least squares matrix. | 05-24-2012 |
20120121536 | COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION - Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research. | 05-17-2012 |
20120095621 | TRAJECTORY TRACKING FLIGHT CONTROLLER - A six degree-of-freedom trajectory linearization controller (TLC) architecture ( | 04-19-2012 |
20120070889 | HYBRID BIOREACTOR FOR REDUCTION OF CAPITAL COSTS - A bioreactor with first and second containers has translucent sidewalls housing a plurality of planar membranes over which a slurry of water and photosynthetic microorganisms flows. A light collector is mounted adjacent a gap between the first and second containers for receiving incident light and conveying the light through optical waveguides, such as fibers, to distributors. The distributors are mounted in the first and second containers near a lower end of the substrates so that photons incident on the optical waveguides are conveyed through the optical waveguides to the light distributors and then to the lower ends of the substrates where light passing through the translucent sidewalls is less intense. | 03-22-2012 |
20120024719 | REMOVAL OF METALS FROM WATER - A method of purifying water is provided that includes applying a voltage to an electrolytic cell | 02-02-2012 |
20120016601 | METHOD AND SYSTEM FOR DETERMINING PROPERTIES OF AN ASPHALT MATERIAL - A method for determining properties of an asphalt material include measuring respective current deformations of a plurality of samples of the asphalt material, repeating the measuring step over a plurality of temperatures that change at a predetermined rate, calculating a plurality of measured total strain values as a function of the deformations and the temperatures, calculating respective creep strains, at different ones of the plurality of temperatures, based on the total strains as a function of applied stresses, calculating respective creep stiffnesses as a function of the temperatures, determining a combined creep curve based on the respective creep stiffnesses, deriving a theoretical creep curve, and fitting the theoretical creep curve with the combined creep curve to determine a master creep curve function and a time-temperature shift function. | 01-19-2012 |
20110313182 | PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN - The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art. | 12-22-2011 |
20110302909 | Selective Catalytic Reduction Via Electrolysis of Urea - A method for producing ammonia suitable for use as a reductant in a combustion exhaust gas treatment system is provided that includes the electrolytic hydrolysis of urea under mild conditions. The ammonia generator, which includes an electrolysis apparatus including an electrolytic flow cell, an alkaline electrolyte composition, and a recirculation system, may be operatively coupled to an exhaust gas treatment system to provide an apparatus for reducing nitrogen oxides (NO | 12-15-2011 |
20110300641 | PROTEIN ISOFORMS FOR DIAGNOSIS - Several aspects of this invention relate to diagnosis of diabetic states in a mammal using protein isoforms. In some aspects, it relates to a method for determining the diabetic state of a mammal. This method can include, for example, (a) measuring the serum concentration of one or more protein isoforms, (b) analyzing the serum concentration of the one or more protein isoforms, and (c) determining the diabetic state of the mammal. Other aspects include kits used to perform the method. Further aspects are the isolated protein isoforms themselves, and their methods of isolation. | 12-08-2011 |
20110247973 | EXFILTRATION APPARATUS - An exfiltration apparatus for removing contaminants from a fluid includes a housing, a filter portion positioned within the housing, and a particulate collecting member. The housing defines a fluid flow path extending from a fluid inlet disposed on a first side of the housing to a fluid outlet disposed on a second side of the housing. The particulate collecting member is disposed within the housing between the fluid inlet and the filter portion. The particulate collecting member includes a recessed particulate collecting portion proximate the filter portion and a raised apertured portion proximate the fluid inlet. Fluid flowing along the fluid flow path passes through the particulate collecting member and through the filter portion before exiting through the fluid outlet. | 10-13-2011 |
20110243823 | Selective Catalytic Reduction Via Electrolysis of Urea - A method and apparatus for producing ammonia suitable for use as a reductant in a selective catalytic reduction (SCR), a selective non-catalytic reduction (SNCR), or a flue gas conditioning system is provided. A method for treating combustion exhaust gas with ammonia is provided that includes the electrolytic hydrolysis of urea under mild conditions. The electrolysis apparatus includes an electrolytic cell, which may be operatively coupled to an exhaust gas treatment system to provide an apparatus for reducing nitrogen oxides (NO | 10-06-2011 |
20110230404 | Glycoproteins Produced in Plants and Methods of Their Use - Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed. | 09-22-2011 |
20110217766 | Methods of Producing Peptides in Plants and Peptides Produced Thereby - Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion are present. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are also present. | 09-08-2011 |
20110191646 | Fault-and Variation-Tolerant Energy - and Area-Efficient Links for Network-on-Chips - The present invention provides methods for detecting and correcting transmission errors in inter-router links of Network-on-Chip (NoC) architectures. A NoC has repeaters along its bus lines. The output of a main repeater is compared and multiplexed with the output of a shadow repeater. If these outputs are the same the multiplexer outputs the output of the main repeater, otherwise an error is detected and the multiplexer outputs the output of the shadow repeater. | 08-04-2011 |
20110186725 | METHOD FOR SEQUENCING PEPTIDES AND PROTEINS USING METASTABLE-ACTIVATED DISSOCIATION MASS SPECTROMETRY - Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas. | 08-04-2011 |
20110146853 | Titanium Alloy Microstructural Refinement Method and High Temperature, High Strain Rate Superplastic Forming of Titanium Alloys - A method for refining the microstructure of titanium alloys in a single thermomechanical processing step, wherein the titanium alloy comprises boron. In some embodiments, the method comprises the steps of first adding boron to the titanium alloy then subjecting the boron-containing titanium alloy to a thermomechanical processing step. Also provided is a method for achieving superplasticity in titanium alloys comprising the steps of selecting a boron-containing titanium alloy, determining the temperature and strain rate necessary to achieve beta superplasticity, and applying sufficient temperature and strain rate to the boron-containing titanium alloy to deform the alloy to the desired shape. Also provided methods of forming titanium alloy parts and the parts prepared by these methods. | 06-23-2011 |
20110056376 | LOW COST COMPOSITE DISCHARGE ELECTRODE - A the discharge electrode made of at least two parts. One part is the mast, which is made from substantially non-electrically conductive material, such as a CPVC pipe. The second part is a spike-carrying elongated member, such as a wire, made of substantially electrically conductive material, with sharpened spikes extending from the wire. The spike-carrying elongated member is attached to the mast, such as by winding around the mast in a helical pattern, and connected to an electrical device. The spikes extend away from the mast. | 03-10-2011 |
20100279255 | Vehicle simulator system - A vehicle simulation system may include: a platform positioned within a three-dimensional workspace, at least six upper support members positioned outside the three-dimensional workspace, at least six upper adjustable cables routed from corresponding upper support members and secured to the platform to apply at least a portion of upward tension to the platform, and a vehicle secured to the platform. The vehicle may provide one or more occupants with a simulated experience within a three-dimensional virtual environment as the upper adjustable cables are adjustably extended and retracted in a coordinated fashion to maneuver the platform. | 11-04-2010 |
20100261874 | SYNTHETIC GENES FOR PLANT GUMS AND OTHER HYDROXYPROLINE RICH GLYCOPROTEINS - A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAUP), is taught in host cells, including plant host cells. | 10-14-2010 |
20100258717 | ON-LINE AND OFF-LINE COUPLING OF ELECTROCHEMISTRY (EC) WITH LIQUID SAMPLE DESORPTION ELECTROSPRAY-MASS SPECTROMETRY (DESI-MS) - An apparatus for direct analysis of the redox products, or intermediates, of an electrochemical reaction by coupling an electrochemical cell to desorption electrospray ionization mass spectrometry. | 10-14-2010 |
20100252422 | CARBON FIBER-ELECTROCATALYSTS FOR THE OXIDATION OF AMMONIA AND ETHANOL IN ALKALINE MEDIA AND THEIR APPLICATION TO HYDROGEN PRODUCTION, FUEL CELLS, AND PURIFICATION PROCESSES - Electrocatalysts useful for the oxidation of ammonia and ethanol in alkaline media. The electrocatalysts include a carbon support, a first plating layer having a strong affinity for OH, and a second plating layer having a strong affinity for oxidation of ammonia or ethanol. The carbon support may be selected from such materials as carbon fibers, carbon tubes, carbon microtubes, and carbon microspheres. The first plating layer is selected from rhodium, ruthenium, nickel and palladium and combinations thereof. The second plating layer is selected from platinum, indium, and combinations thereof. Also provided are electrolytic cells for the production of hydrogen including one or more electrocatalysts described herein, a basic electrolyte, and ammonia or ethanol. Also provided are ammonia fuel cells and ethanol fuel cells utilizing the electrocatalysts described herein. | 10-07-2010 |
20100248330 | Flow-Controlling Header - An apparatus and method for holding a membrane, screen or other flexible planar body in tension, while providing a conduit for water or other liquid to flow to the membrane being held. The membrane extends from inside a manifold body that carries the liquid, and the manifold body supports the membrane at one edge while the membrane is pulled in tension. Liquid pressure builds up inside the manifold body, preferably by entering a pressure chamber at the top of the manifold body. At a feeding pressure in the pressure chamber the liquid is distributed to the membrane for microbe growth. The liquid can be elevated to a higher, microbe-harvesting pressure by increasing the pressure in the pressure chamber, thereby deflecting a shim separating the pressure chamber from the membrane. The change in pressure is carried out by manually or automatically opening and closing a conventional water valve. | 09-30-2010 |
20100233293 | PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN - The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art. | 09-16-2010 |
20100092929 | Cognitive and Linguistic Assessment Using Eye Tracking - Methods for assessing cognitive and linguistic abilities by tracking and recording the eye movements of a patient in response to predetermined verbal and visual stimuli. The methods incorporate conventional eye-tracking technology to acquire eye-fixation location and duration measures for testing linguistic comprehension, working memory, attention allocation, and the effect of semantic associative priming. Visual stimuli presented in the methods are carefully designed to reduce visually distracting features. Verbal stimuli are carefully designed to control for numerous linguistic features. | 04-15-2010 |
20100072358 | PORTABLE LOEB-EIBER MASS SPECTROMETER - A portable mass spectrometer including an ion source, an ion detector, and a Loeb-Eiber style high-pass ion separator comprising an array of wires. The array can have first and second sets of wires where the distance between adjacent wires is less than the diameter of each of the wires. An electrical generator can be configured to create an electrical current and supply the electrical current to the first set of wires while the second set of wires remains grounded. | 03-25-2010 |
20100064756 | MICRO-CHANNEL TUBES AND APPARATUS AND METHOD FOR FORMING MICRO-CHANNEL TUBES - An apparatus and method are provided for extruding a micro-channel tube ( | 03-18-2010 |
20100059674 | METHOD AND APPARATUS OF LIQUID SAMPLE-DESORPTION ELECTROSPRAY IONIZATION-MASS SPECROMETRY (LS-DESI-MS) - An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage. | 03-11-2010 |
20100056779 | SYNTHESIS OF METHYL NONACTATE DERIVATIVES - Methyl nonactate is converted into a variety of different triazoloamide antibacterial agents by a reaction scheme involving (1) inversion of the secondary alcohol of the methyl nonactate to produce the corresponding azidoester, (2) converting the azido ester to the corresponding azidoamide, and (3) converting the azido group of the azidoamide to a triazole to produce the corresponding triazoloamide. | 03-04-2010 |
20100056483 | METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF BONE LOSS - Disclosed herein are methods and compositions for the treatment and prevention of bone loss. The methods comprise providing a therapeutically effective amount of at least one chelating agent to a subject. The methods further comprise providing a therapeutically effective amount of estrogen or at least one estrogen analogue to a subject. Compositions disclosed herein for the treatment and prevention of bone loss comprise a chelator and estrogen or at least one estrogen analogue. The compositions further comprise at least one of a bisphosphonate, a selective estrogen receptor modulator, or a hormone. | 03-04-2010 |
20100032320 | ELECTROCHEMICAL TECHNIQUE TO MEASURE CONCENTRATION OF MULTIVALENT CATIONS SIMULTANEOUSLY - Methods and systems for simultaneously measuring concentration of two or more different cations in solution. The methods include the steps of applying a steady state polarization technique to a solution comprising two or more different cations; measuring the limiting currents of the solution; and correlating the limiting currents with the concentration of the different cations. The system includes a working electrode; a potentiostat; a counter electrode; a reference electrode; a solution comprising different cations to be analyzed; and a model for correlating the limiting currents with the concentration of the pair cations. The working electrode may be any electrode compatible with the media, including noble metals, carbon, or combinations thereof. In some embodiments, the working electrode is a rotating disk electrode (RDE). | 02-11-2010 |
20100029548 | GLYCOPROTEINS PRODUCED IN PLANTS AND METHODS OF THEIR USE - Methods of increasing the yield in plant expression of recombinant proteins comprising: engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed. | 02-04-2010 |
20100028993 | METHODS OF PRODUCING PEPTIDES IN PLANTS AND PEPTIDES PRODUCED THEREBY - Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion are present. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are also present. | 02-04-2010 |
20100028326 | DIAGNOSIS OF HYPERINSULINEMIA AND TYPE II DIABETES AND PROTECTION AGAINST SAME BASED ON PROTEINS DIFFERENTIALLY EXPRESSED IN SERUM - Mouse proteins differentially expressed in serum, in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic white adipose tissue have been identified, as have corresponding human proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequalae. | 02-04-2010 |
20090252999 | Solid Oxide Fuel Cell Process and Apparatus - Conveying gas containing sulfur through a sulfur tolerant planar solid oxide fuel cell (PSOFC) stack for sulfur scrubbing, followed by conveying the gas through a non-sulfur tolerant PSOFC stack. The sulfur tolerant PSOFC stack utilizes anode materials, such as LSV, that selectively convert H | 10-08-2009 |
20090203150 | METHODS AND SYSTEMS FOR IDENTIFYING INSULIN MIMETICS - Methods are provided for identifying and selecting candidate molecules that activate glucose transport through binding of the insulin receptor at a site other than the insulin binding site. The methods include analyzing the properties of one or more candidate molecules in terms of the ability to bind the insulin receptor and activate glucose transport. Optionally the methods include, competitive assays in the presence of the glucose receptor, a candidate molecule, and one or more of insulin, alpha PGG and beta PGG. | 08-13-2009 |
20090127094 | ELECTRO-CATALYSTS FOR THE OXIDATION OF AMMONIA IN ALKALINE MEDIA - An electro-catalyst for the oxidation of ammonia in alkaline media; the electrocatalyst being a noble metal co-deposited on a support with one or more other metals that are active to ammonia oxidation. In some embodiments, the support is platinum, gold, tantalum, or iridium. In some embodiments, the support has a layer of Raney metal deposited thereon prior to the deposition of the catalyst. Also provided are electrodes having the electro-catalyst deposited thereon, ammonia electrolytic cells, ammonia fuel cells, ammonia sensors, and a method for removing ammonia contaminants from a contaminated effluent. | 05-21-2009 |
20090117002 | NANOPARTICLE ASSEMBLIES WITH MOLECULAR SPRINGS - A nanoscale sensing device from different types of nanoparticles (NPs) and nanowires (NWs) connected by molecular springs. The distance between the nanoscale colloids reversibly changes depending on conditions or analyte concentration and can be evaluated by fluorescence measurements. | 05-07-2009 |
20090095636 | Electrolytic Cells and Methods for the Production of Ammonia and Hydrogen - A method using an electrolytic cell to electrolyze urea to produce at least one of H | 04-16-2009 |
20090081500 | FUEL CELL UTILIZING AMMONIA, ETHANOL OR COMBINATIONS THEREOF - An fuel cell utilizing ammonia, ethanol, or combinations thereof, comprising: a housing; an anode disposed within the housing, the anode comprising at least one layered electrocatalyst, wherein the at least one layered electrocatalyst comprises at least one active metal layer and at least one second metal layer deposited on a carbon support; a basic electrolyte disposed adjacent the anode; a cathode disposed adjacent the basic electrolyte, wherein the cathode comprises a conductor; and an oxidant in communication with the cathode for connecting with a power conditioner, a load, or combinations thereof, wherein the power conditioner, the load, or combinations thereof is in communication with the anode, which oxidizes the ammonia, ethanol, or combinations thereof, causing the fuel cell to form an electric current. | 03-26-2009 |
20090050798 | Method for Sequencing Peptides and Proteins Using Metastable-Activated Dissociation Mass Spectrometry - Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas. | 02-26-2009 |
20090050489 | ELECTROCHEMICAL METHOD FOR PROVIDING HYDROGEN USING AMMONIA AND ETHANOL - An electrochemical method for providing hydrogen using ammonia, ethanol, or combinations thereof, comprising: forming an anode comprising a layered electrocatalyst, the layered electrocatalyst comprising at least one active metal layer deposited on a carbon support; providing a cathode comprising a conductor; disposing a basic electrolyte between the anode and the cathode; disposing a fuel within the basic electrolyte; and applying a current to the anode causing the oxidation of the fuel, forming hydrogen at the cathode. | 02-26-2009 |
20090042838 | PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN - The present invention provides phosphaplatins, stable isolated monomeric phosphate complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes-unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents-do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art. | 02-12-2009 |
20090030185 | SYNTHETIC GENES FOR PLANT GUMS AND OTHER HYDROXYPROLINE-RICH GLYCOPROTEINS - A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells. | 01-29-2009 |
20080319185 | Efficient Method To Synthesize Benzyl Group-Protected Alpha-Pentagalloylglucose (Alpha-Pgg) And Its Analogues - A method to synthesize benzyl group protected alpha-pentagalloylglucose (α-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding α-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent. | 12-25-2008 |
20080318097 | ELECTROCHEMICAL CELL FOR OXIDATION OF AMMONIA AND ETHANOL - An electrochemical cell for causing a reaction that produces hydrogen, the electrochemical cell comprising: a first electrode comprising: at least one layered electrocatalyst formed of at least one active metal layer deposited on a carbon support, wherein the at least one active metal layer is active to a target species; a second electrode comprising a conductor; a basic electrolyte; ammonia, ethanol, or combinations thereof; and electrical current in communication with the first electrode. | 12-25-2008 |
20080314755 | LAYERED ELECTROCATALYST FOR OXIDATION OF AMMONIA AND ETHANOL - A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst. | 12-25-2008 |
20080262198 | Cross-Linkable Glycoproteins and Methods of Making the Same - Non-naturally occurring peptides/polypeptides/proteins comprising the crosslinking motif, Tyr-X-Tyr, wherein X is any amino acid, and methods of preparing the same. | 10-23-2008 |
20080249299 | Pgg Separation and Purification - A simple, inexpensive, and efficient method for,separation and purification of the α- and β-FORMS OF penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separating α-PGG or β-PGG from a mixture that contains α-PGG and β-PGG and other chemicals. The method for separation of α-PGG from a mixture of α-PGG and β-PGG comprises the steps of adding water to a sample containing 50% or morec α-PGG and 50% or less β-PGG; mixing the PGG and watcr to dissolve thc, PGG; filtering out any undissolvcd particles; and allowing the filtercd solution to stand undisturbcd until crystals form. | 10-09-2008 |
20080245710 | EXFILTRATION APPARATUS - An exfiltration apparatus for removing contaminants from a fluid, the exfiltration apparatus including a housing defining a fluid flow path and having a first filter/sorptive layer positioned within a first portion of the housing and a second filter/sorptive layer positioned within a second portion of the housing. The first portion of the housing and the first filter/sorptive layer are removable as a unit from the second portion of the housing. The exfiltration apparatus may also include a container positioned within the second filter/sorptive layer and a third filter/sorptive layer disposed within the container. The exfiltration apparatus may also include a container defining a fluid retaining chamber. The chamber may be generally positioned between the first filter/sorptive layer and the second filter/sorptive layer. | 10-09-2008 |
20080242834 | Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products - Proteins with Hyp-glycosylation are more likely to be secreted in plant cells at high levels than those without. Methods are disclosed for the prediction of Pro-hydroxylation and Hyp-glycosylationsites in proteins. Such methods can be used to identify (1) proteins which, without modification, are predisposed to develop Hyp-glycosylation, if expressed in plant cells, and (2) modifications (especially substitution mutations) which increase the propensity of a protein to develop Hyp-glycosylation, with a view to high level or increased secretion. It is also possible to determine empirically whether a particular protein will undergo Hyp-glycosylation suitable for the desired level of secretion in plant cells. Both modified proteins, and methods for the expression and secretion of predisposed and modified proteins, are claimed. | 10-02-2008 |
20080238772 | METHOD AND APPARATUS FOR USING MULTIPATH SIGNAL IN GPS ARCHITECTURE - A method and apparatus for constructive use of a multipath signal in GPS signal processing is provided. In one embodiment, the method includes: a) receiving a GPS signal at a mobile object from a satellite vehicle, b) determining a distance characteristic relating a reflecting object to the mobile object, c) determining at least one inertial characteristic associated with the mobile object, d) predicting at least one multipath signal characteristic associated with reflection of the GPS signal by the reflecting object toward the mobile object, and e) determining the GPS signal received in a) includes a multipath signal associated with reflection of the GPS signal by the reflecting object toward the mobile object. In one embodiment, the apparatus includes: a GPS receiver, a storage device, an inertial measurement device, and a controller. In another embodiment, the apparatus also includes a distance measurement device. | 10-02-2008 |
20080234951 | Gravity Flowmeter for Materials Analysis - Properties of asphalt are determined by determining an expansion of a plurality of samples of the asphalt as a function of current dimensions of the respective samples, determining a creep of the samples as a function of the current dimensions of the respective samples, repeating the determining steps over a plurality of temperatures, and determining a master creep modulus and a temperature coefficient of the asphalt as a function of the plurality of expansions and the plurality of creeps. | 09-25-2008 |
20080220403 | SYSTEM AND METHOD FOR MANAGING DIABETES - A system and method are provided for automatically analyzing data for a patient with type 1 diabetes on insulin pump therapy and recommending appropriate therapeutic adjustments to the patient. In the system and the method, case-based reasoning is used as a primary reasoning modality in determining the therapeutic adjustments. | 09-11-2008 |