NORTHWESTERN UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160102356 | ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4 - The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C). | 04-14-2016 |
20160089354 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Cancer Cell Growth - Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia. | 03-31-2016 |
20160083688 | IMPROVED METHODS FOR MAKING RIBOSOMES - A platform for preparing a sequence defined biopolymer in vitro is disclosed. The platform includes a ribosome-depleted cellular extract ribosomal RNAs prepared by in vitro transcription and purified ribosomal proteins depleted of ribosomal RNAs. A method of synthesizing and assembling ribosomes in vitro for use in the platform is provided, as well as a method for preparing a sequence defined biopolymer in vitro using assembling ribosomes and the platform. | 03-24-2016 |
20160076102 | MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS - Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia. | 03-17-2016 |
20160061825 | Kits for Fecal Neopterin Concentration Measurement as an Indicator of Disease Activity in Inflammatory Bowel Disease - Disclosed are methods for determining disease activity in a patient having or at risk for developing inflammatory bowel disease (IBD) which include measuring neopterin concentration in a fecal sample from the patient. | 03-03-2016 |
20160060702 | METHODS, KITS, AND DEVICES FOR DIAGNOSING, PROGNOSING, AND TREATING PSYCHIATRIC DISORDERS IN A PATIENT - Disclosed are methods, kits, and devices for diagnosing and treating psychiatric, disorders and the symptoms thereof. The methods, kits, and devices relate to identifying genetic markers that may be utilized to diagnose and/or prognose a patient and treat the diagnosed and/or prognosed patient by administering a drug the patient based on the genetic marker having been identified. Genetic markers identified in the methods may include HTR2C polymorphisms such as a polymorphism resulting in a Cys23Ser amino acid substitution, an rs3813929 (−759C/T) polymorphism, and an rs518147 (−697G/C) polymorphism). | 03-03-2016 |
20160060301 | METHODS FOR IMPROVED IN VITRO PROTEIN SYNTHESIS WITH PROTEINS CONTAINING NON STANDARD AMINO ACIDS - The invention relates to genomically recoded organisms, platforms for preparing sequence defined biopolymers in vitro comprising a cellular extract from a genomically recorded organism, and methods for preparing sequence defined biopolymers in vitro are described. In particular, the invention relates to genomically recoded organisms comprising a strain deficient in release factor 1 (RF-1) or a genetic homolog thereof and at least one of at least one additional genetic knock-out mutation, at least one additional upregulated gene product, or both at least one additional knock-out mutation and at least one additional upregulated gene product. | 03-03-2016 |
20160052870 | 3-AMIDOBENZAMIDES AND USES THEREOF FOR INCREASING CELLULAR LEVELS OF A3G AND OTHER A3 FAMILY MEMBERS - Disclosed are novel benzamide compounds and the uses thereof for treating diseases and disorders in a patient in need thereof by increasing cellular levels of A3G and/or other members of the A3 family of proteins in the patient. The disclosed compounds include | 02-25-2016 |
20160046815 | Surface-Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof - The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality. | 02-18-2016 |
20160040127 | USE OF LIGANDS FOR THE PROGRAMMED CELL DEATH RECEPTOR CONJUGATED TO SOLID SUPPORTS FOR THE EXPANSION OF HUMAN REGULATORY T CELLS - Disclosed are methods for isolating, cultivating, and/or cells including regulatory T cells (Tregs). The methods typically include cultivating cells including Tregs in a culture media comprising a ligand for programmed cell death receptor (PD-1) conjugated to a solid support. Suitable ligands may include PD-L1 and suitable solid supports may include magnetic or paramagnetic beads where the methods further include removing the PD-L1/bead conjugates after the Tregs have been isolated, cultured, and/or expanded. | 02-11-2016 |
20160030531 | BACTERIAL TOXINS AND USES THEREOF AS RAS SPECIFIC PROTEASES - Disclosed are bacterial toxins and uses thereof as specific proteases for Ras sarcoma oncoproteins (Ras proteins). The bacterial toxins may be modified for use as pharmaceutical agents for treating Ras-dependent diseases and disorders including cell proliferation diseases and disorders such as cancer. | 02-04-2016 |
20160016893 | SCREENING METHODS FOR THE BINDING AFFINITY OF CHEMICAL ENTITIES TO BIOLOGICAL MOLECULES AND NEDD4-1 INHIBITORS IDENTIFIED BY THE SCREENING METHODS - Disclosed are methods for screening for the binding affinity of chemical entities to other bioactive molecules. The screened chemical entities may be utilized in pharmaceutical composition or therapeutic methods for treating disease or disorders associated with the bioactive molecules including NEDD4-1. | 01-21-2016 |
20160002252 | SUBSTITUTED PYRROLO[2,3-d]PYRIMIDINES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS - Disclosed are substituted pyrrolo[2,3-d]pyrimidine compounds. The disclosed compounds are shown to be useful in inhibiting the growth of cancer cell lines and treating cancer and cell proliferative disorders. | 01-07-2016 |
20150366662 | Medical Devices, Systems, and Kits for the Medialization of a Vocal Cord - Medical devices, systems, methods, and kits for the medialization of a vocal cord are described. An embodiment of a medical device comprises a proximal portion, a distal portion, and an elongate body extending from the proximal portion to the distal portion. The elongate body defines a thread extending from the proximal portion and the distal portion. | 12-24-2015 |
20150315237 | NMDA Receptor Modulators and Uses Thereof - Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. | 11-05-2015 |
20150309073 | MULTIFUNCTIONAL GRAPHENE COATED SCANNING TIPS - A coat micro tip can include a tip having a base and an oppositely disposed tip end having a radius of curvature of less than 1 μm and a graphene film conformally coated on the tip. A method of making a graphene coated tip can include immersing a tip in a fluid comprising a graphene film floating on a surface of the fluid over the tip, disposing the immersed tip at an angle relative to the graphene film floating on the surface of the fluid as measured from a plane parallel to the base of the tip, and coating the tip with the graphene film by gradually bringing the graphene film into contact with the tip while maintaining the relative angle between the floating portion of the film and the tip during coating | 10-29-2015 |
20150292036 | CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS - The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject. | 10-15-2015 |
20150265436 | VACUUM PUMP SYSTEMS FOR PROSTHETIC LIMBS AND METHODS OF USING THE SAME - Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a mechanically activated pump having a first compression member coupled to a second compression member, a compressible bladder disposed between the first and second compression members, and coupling elements that engage and couple together the first and second compression members. The mechanically activated pump may be connected with an electrically activated pump within a fluid circuit of a hybrid pump system to provide vacuum engagement between a prosthetic device and a residual limb. | 09-24-2015 |
20150265435 | VACUUM PUMP SYSTEMS FOR PROSTHETIC LIMBS AND METHODS OF USING THE SAME - Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a mechanically activated pump having a first compression member coupled to a second compression member, a compressible bladder disposed between the first and second compression members, and coupling elements that engage and couple together the first and second compression members. The mechanically activated pump may be connected with an electrically activated pump within a fluid circuit of a hybrid pump system to provide vacuum engagement between a prosthetic device and a residual limb. | 09-24-2015 |
20150210679 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION - Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors which may be administered in methods of treating diseases or disorders associated with elevated SOD expression or activity, including neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS). | 07-30-2015 |
20150191470 | CRYSTALLINE BIPYRIDINIUM RADICAL COMPLEXES AND USES THEREOF - Described herein are methods of generating 4,4′-bipyridinium radical cations (BIPY | 07-09-2015 |
20150175555 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS - The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. | 06-25-2015 |
20150175503 | FORMING ETHYLENE - A method that includes forming ethylene from methane including contacting supported-palladium with hydrogen sulfide to form a palladium sulfide catalyst and contacting the palladium sulfide catalyst with methane to form ethylene. | 06-25-2015 |
20150150996 | COMPOSITIONS AND METHODS FOR ANTIGEN-SPECIFIC TOLERANCE - The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject. | 06-04-2015 |
20150139883 | CERIA-SUPPORTED METAL CATALYSTS FOR THE SELECTIVE REDUCTION OF NOX - A composition and method for producing the same are provided. The composition includes transition metal oxides adhered to a surface of a cerium oxide support, and can additionally include alkali metal or alkaline earth metal promotors. The method includes incipient wetness impregnation of the support with metal salt in solution, and can include impregnation with a metal chelator salt. The composition can be useful as a catalyst for the reduction of noxious gases in combustion exhaust streams. The composition can be of particular use as a component of an automobile catalytic converter, for the specific catalytic reduction of nitrogen oxides to nitrogen gas. | 05-21-2015 |
20150137403 | Deformation-based micro surface texturing system - A compact deformation-based micro-texturing apparatus and method employ flexure bearing houses for rotatably supporting opposite ends of each of a first (e.g. upper) roll and a second (e.g. lower) roll to provide a working roll gap between the rolls, wherein at least one of the rolls has one or more micro surface features to plastically deform a surface of a workpiece deformed by rolling action in the roll gap. An electrical current may be passed through the workpiece to assist micro deformation. A roll gap adjusting device is operably associated with the first and second flexure bearing houses for adjusting the roll gap dimension to the final depth of the micro surface features to be imparted to the surface of the workpiece by the rolling action. A sheet material or antifriction element (e.g. journal bearing or bushing) is produced having at least one surface that includes rolled-in micro surface depressions wherein depressions have a lateral dimension of about 1 μm to about 10 mm and a depth of about 1 μm to about 10 mm, typically a lateral dimension of about 1 μm to about 100 μm and a depth of about 1μm to about 100 μm. | 05-21-2015 |
20150105364 | NMDA Receptor Modulators and Uses Thereof - Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. | 04-16-2015 |
20150099741 | DIAGNOSING AND TREATING PATIENTS HAVING PSYCHIATRIC DISORDERS - Disclosed are methods and kits for diagnosing, prognosing, and treating patients having psychiatric disorders. The methods may include assessing whether a patient has a treatment resistant psychiatric disorder or assessing whether the patient is likely to develop a treatment resistant psychiatric disorder. The methods may include detecting genetic markers such as the single nucleotide polymorphism (SNP) in genes present in a genomic nucleic acid sample from the patient, and/or receiving, as a caregiver, the results of tests indicating whether the genetic markers are present in the genomic nucleic acid sample from the patient. The methods may include administering treatment to the patient, for example, based on the detected genetic markers, and administering treatment may include administering new antipsychotic drugs (APDs) that are trace amine-associated receptor 1 (TAAR1) agonists. | 04-09-2015 |
20150093433 | TARGETED AND MODULAR EXOSOME LOADING SYSTEM - Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes an RNA-binding domain and an exosome-targeting domain. The cargo RNA includes an RNA-motif that the RNA-binding domain of the fusion protein binds specifically such that the cargo RNA is packaged in the lumen of the exosomes. | 04-02-2015 |
20150065703 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS - Disclosed are a new method for synthesizing 7-membered fused heterocycles and compounds synthesized by the new method. The method involves a dual activation strategy using an N-heterocyclic carbene catalyst as a first Lewis base and another second Lewis base. Compounds synthesized by the disclosed method may include new benzoxopinone compounds, as well as benzoxepane compounds and benzoazepinone compounds that optionally may be derived from the disclosed benzoxopinone compounds. | 03-05-2015 |
20150064255 | NANOSTRUCTURES FOR TREATING CANCERS AND OTHER CONDITIONS - Nanostructures, compositions and methods for treating cancers and other conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers or other diseases or conditions at least in part by controlling cholesterol metabolism in cells. The nanostructures and compositions may be used, for example, to control cholesterol influx and/or efflux in cells. In some cases, the nanostructures or compositions may be used to kill the cells. Examples of cancer cells that may be affected by the nanostructures and compositions described herein include those having scavenger receptor type B-I (SR-B1), B-cell lymphoma cells, non-Hodgkin's lymphoma cells, melanoma cells and/or others. In some embodiments, the nanostructures may be mimics of natural high-density lipoprotein (HDL). | 03-05-2015 |
20150051262 | NMDA RECEPTOR MODULATORS AND USES THEREOF - Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. | 02-19-2015 |
20150037833 | CONTAINER AND SYSTEM FOR SAMPLE COLLECTION AND PREPARATION - The present invention relates to a system for collecting and preparing a body fluid sample, the system comprising a sample container ( | 02-05-2015 |
20150031745 | NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER - The present disclosure is directed to nanoconjugates that cross the blood-brain barrier and methods of their therapeutic use. | 01-29-2015 |
20150031127 | SELF-ASSEMBLED NANOSTRUCTURES - The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures. | 01-29-2015 |
20150027309 | SELECTIVE ADSORBENT - Embodiments include selective adsorbents having a structure of Formula (I) where a connection to X represents a connection to a structure of Formula (II), and a connection to Y represents a connection to a structure of Formula (III), where each R | 01-29-2015 |
20140364391 | Immobilization Of An Active Agent On A Substrate Using Compounds Including Trihydroxyphenyl Groups - The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof. | 12-11-2014 |
20140355798 | Hearing Assistance Device Control - A hearing assistance device may be a hearing aid worn on a person or a mobile device. The hearing assistance device may perform a hearing assistance algorithm based on signal processing parameters. A set of audiological values for a population may be identified. The set of audiological values has a first number of dimensions. The set of audiological values is converted to a reduced data set. The reduced data has set has a second number of dimensions less than the first number of dimensions. A processor calculates a trajectory for the reduced data set. The trajectory provides signal processing parameters for the hearing assistance device. | 12-04-2014 |
20140349405 | RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS - Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from | 11-27-2014 |
20140349191 | ELECTRODE MATERIAL COMPRISING GRAPHENE-COMPOSITE MATERIALS IN A GRAPHITE NETWORK - A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, wherein the electrically active material is dispersed between, and supported by, the graphene sheets. | 11-27-2014 |
20140348895 | PARA-XYLENE FILMS AND THERAPEUTIC USES THEREOF - The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place. | 11-27-2014 |
20140345351 | APPARATUS FOR ELECTRICAL-ASSISTED INCREMENTAL FORMING AND PROCESS THEREOF - A process and apparatus for forming a sheet metal component using an electric current passing through the component. The process can include providing an incremental forming machine, the machine having at least one arcuate tipped tool and at least electrode spaced a predetermined distance from the arcuate tipped tool. The machine is operable to perform a plurality of incremental deformations on the sheet metal component using the arcuate tipped tool. The machine is also operable to apply an electric direct current through the electrode into the sheet metal component at the predetermined distance from the arcuate tipped tool while the machine is forming the sheet metal component. | 11-27-2014 |
20140335623 | METHODS AND COMPOSITIONS FOR GENERATING SPORULATION DEFICIENT BACTERIA - The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class Clostridia. In particular, the present invention relates to the generation of sporulation deficient bacteria for the generation of industrial superior phenotypes. | 11-13-2014 |
20140330148 | CYCLE LENGTH ITERATION FOR THE DETECTION OF ATRIAL ACTIVATIONS FROM ELECTROGRAM RECORDINGS OF ATRIAL FIBRILLATION - A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram. | 11-06-2014 |
20140329967 | Substrate-Independent Layer-By-Layer Assembly Using Catechol-Functionalized Polymers - The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surface-independent fashion is also provided. | 11-06-2014 |
20140329217 | SURGICAL SIMULATORS AND METHODS ASSOCIATED WITH THE SAME - Surgical simulators and methods associated with the same are provided. In one aspect, a surgical simulator includes a rib cage including a plurality of ribs, internal tissue positionable within the rib cage, and external tissue adapted to cover at least a portion of the rib cage. In another aspect, a method of manufacturing a surgical simulator includes forming a rib cage including a plurality of ribs, positioning internal tissue within the rib cage, and at least partially covering the rib cage with external tissue. In a further aspect, a method of modifying biologic tissue for use with a surgical simulator is provided. | 11-06-2014 |
20140322731 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 10-30-2014 |
20140322190 | Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques - Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator. | 10-30-2014 |
20140311297 | COMPOUNDS AND METHODS TO ISOLATE GOLD - Methods for recovering gold from gold-bearing materials are provided. The methods rely upon on the self-assembly of KAuBr | 10-23-2014 |
20140311271 | TRANSLATIONAL PARALLEL MANIPULATORS AND METHODS OF OPERATING THE SAME - In one aspect, a translational parallel manipulator is provided and includes a fixed platform including three guide members. The three guide members include first ends and second ends, and the first ends of the three guide members are all coupled to each other and the second ends of the three guide members are all spaced-apart from each other. The manipulator also includes a movable platform spaced-apart from the fixed platform and three serial subchains coupled between the three guide members and the movable platform. In one aspect, a translational parallel manipulator is provided and includes a fixed platform, a movable platform spaced-apart from the fixed platform, and a plurality of subchains coupled between the fixed platform and the movable platform. At least one of the plurality of subchains includes no more than four one degree-of-freedom joints. | 10-23-2014 |
20140309260 | TREATMENT FOR DOPAMINERGIC DISORDERS - The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type Ca | 10-16-2014 |
20140303279 | ENHANCED DEGRADATION OF POLYMERIC MATERIALS VIA SOLID-STATE SHEAR PULVERIZATION - Solid-state shear pulverization, as can be used to disperse a pro-oxidant component in a polymer component and affect subsequent polymer biodegradation. | 10-09-2014 |
20140302514 | CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS - The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject. | 10-09-2014 |
20140296578 | ALKANE OXIDATION - Embodiments include an alkane oxidation catalyst having a support modified with a carboxylate group. The carboxylate group is functionalized with a manganese complex selected from the group consisting of [(C | 10-02-2014 |
20140295492 | Methods for Cell-Free Protein Synthesis - Cell-free protein synthesis systems and methods of using the same for producing in vitro protein materials in high yield are disclosed. The cell-free protein synthesis platform includes (a) a | 10-02-2014 |
20140294927 | SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES - Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent. | 10-02-2014 |
20140287016 | IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE - The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof. | 09-25-2014 |
20140273066 | AUTOMATED CELL COLLECTION AND SMEARING - The present invention provides systems, devices, and methods for cell collection and/or cell smearing (e.g., on a slide). In particular, provided herein is an cell collection device, a translating slide holder, systems comprising such devices, and methods of use thereof. | 09-18-2014 |
20140272883 | SYSTEMS, METHODS, AND APPARATUS FOR EQUALIZATION PREFERENCE LEARNING - Systems, methods, and apparatus for equalization preference learning are provided. An example method includes receiving a first label for a first audio concept for a media object and applying active learning to select a first example not yet rated by a first current user. The example method includes collecting a first user rating, by the first current user, of the first example compared to the first audio concept and applying transfer learning to combine the first user rating with ratings from prior users of examples not yet rated by the first current user to build a model of the first audio concept. The example method includes creating a tool operable by the first user to generate examples close to and far from the first label to modify the media object. | 09-18-2014 |
20140271889 | MULTIFUNCTIONAL METAL NANOPARTICLES HAVING A POLYDOPAMINE-BASED SURFACE AND METHODS OF MAKING AND USING THE SAME - The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging. | 09-18-2014 |
20140271490 | BACTERIA-TARGETED MAGNETIC RESONANCE CONTRAST AGENTS - The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups. | 09-18-2014 |
20140268371 | Apparatuses and Methods to Image Surfaces with Small Spot-Size and Large Field of View - Apparatuses and methods to image a flat surface with a spot-size that is about less than or equal to the wavelength of an incident planar electromagnetic wave, and with large field of view, are disclosed herein. More specifically, the apparatuses and methods disclosed herein utilize two hemispheres comprised of one or more dielectric materials to produce the Fourier transform of an incident planar electromagnetic wave onto a flat surface located in a projection plane. | 09-18-2014 |
20140256635 | ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF - The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis. | 09-11-2014 |
20140256016 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors - Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity. | 09-11-2014 |
20140249088 | METHODS OF TREATING NEUROPATHIC PAIN - The disclosure relates, at least in part, to methods of treating neuropathic pain in a patient in need thereof by administering an effective amount of a disclosed compound, e.g. a peptide NMDA receptor partial agonist. | 09-04-2014 |
20140234939 | Benzamide Compounds and Related Methods of Use - Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease. | 08-21-2014 |
20140234851 | MODULAR EXTRACELLULAR SENSOR ARCHITECTURE FOR CELL-BASED BIOSENSORS - The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting extracellular ligands. In certain embodiments, the extracellular sensors comprise a ligand binding domain, a transmembrane domain, a protease domain, a protease cleavage site, and a transcription factor. In other embodiments, a pair of extracellular receptors is provided where both receptors contain a ligand binding domain and transmembrane domain, and one receptor contains a protease cleavage site and a transcription factor and the other receptor contains a protease domain. | 08-21-2014 |
20140234369 | LIVE-ATTENUATED COMPOSITIONS FOR BACTERIAL INFECTIONS - The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity. | 08-21-2014 |
20140222808 | METHODS AND APPARATUS FOR FACILITATING DELIVERY OF A SERVICE ASSOCIATED WITH A PRODUCT - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system determines the relevance of a word to the context by utilizing an adaptive weighting system. The information retrieval system assigns varying weights to different attributes of a word and calculates an accumulated weight of the word by accumulating all weights assigned to the word. The attributes may include word size, style, location of the word, etc. The system then ranks the importance of words based on their respective accumulated weight, and chooses words that rank within a predetermined number from the top to form search terms to conduct an information search using various data sources. | 08-07-2014 |
20140222796 | METHODS AND APPARATUS FOR FACILITATING DELIVERY OF A SERVICE ASSOCIATED WITH A PRODUCT - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system determines the relevance of a word to the context by utilizing an adaptive weighting system. The information retrieval system assigns varying weights to different attributes of a word and calculates an accumulated weight of the word by accumulating all weights assigned to the word. The attributes may include word size, style, location of the word, etc. The system then ranks the importance of words based on their respective accumulated weight, and chooses words that rank within a predetermined number from the top to form search terms to conduct an information search using various data sources. | 08-07-2014 |
20140222795 | METHODS AND APPARATUS FOR FACILITATING DELIVERY OF A SERVICE ASSOCIATED WITH A PRODUCT - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system determines the relevance of a word to the context by utilizing an adaptive weighting system. The information retrieval system assigns varying weights to different attributes of a word and calculates an accumulated weight of the word by accumulating all weights assigned to the word. The attributes may include word size, style, location of the word, etc. The system then ranks the importance of words based on their respective accumulated weight, and chooses words that rank within a predetermined number from the top to form search terms to conduct an information search using various data sources. | 08-07-2014 |
20140222794 | METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system determines the relevance of a word to the context by utilizing an adaptive weighting system. The information retrieval system assigns varying weights to different attributes of a word and calculates an accumulated weight of the word by accumulating all weights assigned to the word. The attributes may include word size, style, location of the word, etc. The system then ranks the importance of words based on their respective accumulated weight, and chooses words that rank within a predetermined number from the top to form search terms to conduct an information search using various data sources. | 08-07-2014 |
20140221861 | CONTRIBUTION OF OXIDATIVE STRESS TO AF ELECTROGRAMS - The invention relates generally to methods of detecting reactive oxygen species (ROS) in cardiac tissue and treatment modalities for ablating ROS-associated tissue in cardiac disease. The methods rely upon targeting ROS-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded atrial EGMs for a tissue to assess ROS content and underlying AF organization as a function of ROS blockade conditions. | 08-07-2014 |
20140220115 | NANOPARTICLE ARSENIC-PLATINUM COMPOSITIONS - The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer. | 08-07-2014 |
20140206886 | Enantioselective N-heterocyclic carbene-catalyzed annulation reactions with imidazolidinones - Enantiomeric bicyclic lactone compounds as can be prepared via an N-heterocyclic carbene-catalyzed annulation reaction. | 07-24-2014 |
20140206531 | Activation of Porous MOF Materials - A method for the treatment of solvent-containing MOF material to increase its internal surface area involves introducing a liquid into the MOF in which liquid the solvent is miscible, subjecting the MOF to supercritical conditions for a time to form supercritical fluid, and releasing the supercritical conditions to remove the supercritcal fluid from the MOF. Prior to introducing the liquid into the MOF, occluded reaction solvent, such as DEF or DMF, in the MOF can be exchanged for the miscible solvent. | 07-24-2014 |
20140179637 | METHODS AND COMPOUNDS TO INHIBIT ENVELOPED VIRUS RELEASE - A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus. | 06-26-2014 |
20140163390 | Implantable Biomedical Devices on Bioresorbable Substrates - Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. | 06-12-2014 |
20140162288 | BIOMARKER FOR REPLICATIVE SENESCENCE - The present invention provides biomarkers for replicative senescence. In particular, Lamin B1 is provided as a biomarker for replicative senescence. | 06-12-2014 |
20140155516 | POLY (DIOL CO-CITRATE) HYDROXYAPATITE COMPOSITE FOR TISSUE ENGINEERING AND ORTHOPAEDIC FIXATION DEVICES - The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material. | 06-05-2014 |
20140150510 | SYSTEM AND METHOD FOR INCREMENTAL FORMING - A system includes a frame configured to hold a workpiece and first and second tool positioning assemblies configured to be opposed to each other on opposite sides of the workpiece. The first and second tool positioning assemblies each include a toolholder configured to secure a tool to the tool positioning assembly, a first axis assembly, a second axis assembly, and a third axis assembly. The first, second, and third axis assemblies are each configured to articulate the toolholder along a respective axis. Each axis assembly includes first and second guides extending generally parallel to the corresponding axis and disposed on opposing sides of the toolholder with respect to the corresponding axis. Each axis assembly includes first and second carriages articulable along the first and second guides of the axis assembly, respectively, in the direction of the corresponding axis. | 06-05-2014 |
20140147920 | Specific nNOS Inhibitors for the Therapy and Prevention of Human Melanoma - Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies. | 05-29-2014 |
20140142319 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS - An efficient and highly Markovnikov selective organoactinide-, organolanthanide-, and organozirconium-catalyzed addition of aryl, benzyl, and aliphatic thiols to terminal alkynes is described. The corresponding vinyl sulfides are produced with little or no side-products. | 05-22-2014 |
20140142056 | METHODS OF TREATING CANCER WITH GLUT INHIBITORS AND OXIDATIVE PHOSPHORYLATION INHIBITORS - Disclosed herein are methods of treating, diagnosing, and prognosing GLUT-dependent cancers and OXPHOS-dependent cancers. In some embodiments, the methods comprise administering to a patient in need thereof a GLUT inhibitor and/or an OXPHOS inhibitor. The inhibitors may be administered before, concurrently, or after one another. Suitable GLUT-dependent cancers may include a GLUT4-dependent cancer, a GLUT8-dependent cancer, and a GLUT11-dependent cancer. Suitable GLUT inhibitors may include a GLUT4 inhibitor, a GLUT8 inhibitor, and a GLUT11 inhibitor. Suitable OXPHOS-dependent cancers may include mitochondrial OXPHOS-dependent cancers, including cancers that have developed resistance to treatment with a GLUT-inhibitor. | 05-22-2014 |
20140141516 | METHODS AND COMPOSITIONS FOR GENETICALLY ENGINEERING CLOSTRIDIA SPECIES - The present invention relates to methods and compositions for engineering | 05-22-2014 |
20140134665 | COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC - The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena. | 05-15-2014 |
20140134139 | CD34+ CELLS AND METHODS OF USE - Disclosed herein is a reprogrammed endothelial progenitor cell, said cell comprises a bone marrow-derived cell expressing the CD34+ marker and at least one cardiomyocyte-specific gene, as well as methods for preparing and using the same for cardiac regenerative medicine. | 05-15-2014 |
20140120152 | Scaffold Delivery of Immune Suppressors and Transplant Material for Control of Transplant Rejection - The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular embodiments, immune suppression cells (e.g., regulatory T cells) and transplant material (e.g., cells, tissue, etc.) are provided within a delivery scaffold for transplant into a subject. | 05-01-2014 |
20140113989 | NEGATIVE-SWELLING AND EXCEPTIONALLY ROBUST ADHESIVE HYDROGELS - The present invention provides adhesive hydrogels that negatively swell at physiological temperature. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials were designed that are suitable as medical sealants and adhesives. | 04-24-2014 |
20140107037 | METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, OR OTHER DISORDERS - The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist. | 04-17-2014 |
20140088243 | Solid-State Shear Pulverization/Melt-Mixing Methods and Related Polymer-Carbon Nanotube Composites - Methods using solid-state shear pulverization and melt mixing and related polymer-carbon nanotube composites, as can be used to affect various mechanical and/or physical material properties. | 03-27-2014 |
20140079718 | MAST CELL MARKERS AND PREVENTION, DIAGNOSIS, AND THERAPY FOR CHRONIC PELVIC PAIN SYNDROME - The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e.g. inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome. | 03-20-2014 |
20140074255 | ARTIFICIAL ANKLE, ARTIFICIAL FOOT AND ARTIFICIAL LEG - The present invention relates in the field of orthopedics to an artificial ankle which imitates the natural human gait in a proper way, thereby enabling its user to walk not only in a plane environment but also uphill and downhill without any unpleasant effects. The present invention further relates to an artificial foot and an artificial leg containing said artificial ankle. | 03-13-2014 |
20140074109 | SYSTEM AND METHOD FOR REMOVING AN OBJECT FROM WITHIN A MAMMAL - An object-removal system for removing an object from within a mammal includes a first tubular sheath, a second tubular sheath, a beveled cutting-blade, and a snare. The second tubular sheath is disposed coaxially inside the first tubular sheath. The beveled cutting-blade is attached to a distal end of the second tubular sheath. The snare is disposed within the second tubular sheath for attaching to an object. | 03-13-2014 |
20140066635 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors - Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability. | 03-06-2014 |
20140066587 | Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the Same - The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using citric acid copolymers. | 03-06-2014 |
20140066324 | GENE EXPRESSION SIGNATURE IN SKIN PREDICTS RESPONSE TO MYCOPHENOLATE MOFETIL - Described herein are methods and compositions for identifying patients with SSc or scleroderma who are responders to MMF treatment. | 03-06-2014 |
20140061135 | Water Detoxification by a Substrate-Bound Catecholamine Adsorbent - A bio-inspired method for detoxifying contaminated water is disclosed. In the method, polydopamine, a mussel-inspired adhesive catecholamine was used as an adsorbent to effectively remove from contaminated water three major classes of toxic agents: heavy metal ions (e.g., Cr, Hg, Pb, Cu, and Cd), toxic organic species (e.g., 4-aminopyridine), and radioisotopes (e.g., Lutetium-177). Furthermore, the polydopamine adsorbent was regenerated by treatment with acid or hydrogen peroxide. | 03-06-2014 |
20140058049 | BIODEGRADABLE NITRIC OXIDE GENERATING POLYMERS AND RELATED BIOMEDICAL DEVICES - Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N | 02-27-2014 |
20140057271 | DEVICE WITH CONTROLLED FLUID DYNAMICS, FOR ISOLATION OF AN ANALYTE FROM A SAMPLE - Devices for use in extracting an analyte of interest from a sample are described. In one embodiment, a device is comprised of a first plurality of chambers, where one or more chambers in the plurality of chambers has a deep end and a shallow end with a depth d | 02-27-2014 |
20140045938 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth - Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia. | 02-13-2014 |
20140038849 | METHOD OF ANALYZING AN ANALYTE USING COMBINATORIAL ARRAYS AND UNIFORM PATTERNS - The disclosure relates to a method of analyzing an analyte that includes forming a combinatorial pattern comprising pattern elements with a plurality of sizes and/or structures on a substrate surface with a tilted pen array, applying an analyte to the combinatorial pattern, and identifying a pattern element size and/or structure having a desired effect on an analyte parameter using the combinatorial pattern. The method further includes forming a uniform pattern comprising pattern elements each having substantially the same size and/or structure corresponding to the identified pattern element size and/or structure, and analyzing the effect of pattern element size and/or structure on the analyte parameter using the uniform pattern. | 02-06-2014 |
20140037749 | Delivery Scaffolds and Related Methods of Use - The present invention relates to delivery systems. In particular, the present invention provides microporous scaffolds having thereon agents (e.g., extracellular matrix proteins, exendin-4) and biological material (e.g., pancreatic islet cells). In some embodiments, the scaffolds are used for transplanting biological material into a subject. In some embodiments, the scaffolds are used in the treatment of diseases (e.g., type 1 diabetes), and related methods (e.g., diagnostic methods, research methods, drug screening). | 02-06-2014 |
20140037594 | COMPOSITIONS AND METHODS FOR TREATING BONE FORMATION DISORDERS - The present invention relates to compositions and methods for the detecting, treating, and empirically investigating disorders associated with bone formation (e.g., osteoporosis). In particular, the present invention provides compositions and methods for using maspin and targets of maspin in the diagnosis, treatment, and empirical investigation of disorders associated with bone formation (e.g., osteoporosis). | 02-06-2014 |
20140037588 | INJECTABLE THERMORESPONSIVE POLYELECTROLYTES - Provided herein are compositions, devices and systems comprising thermoresponsive, biodegradable elastomeric materials, and methods of use and manufacture thereof. | 02-06-2014 |
20140037545 | INHIBITION OF FIBROSIS AND AF BY TGF-BETA INHIBITION IN THE POSTERIOR LEFT ATRIUM (PLA) - The disclosed methods pertain to diagnosing whether a non-ablative, gene therapy is needed for reducing AF fibrosis in a subject, and if so, methods of reducing AF fibrosis in a subject using gene therapy with a dominant negative TGF-β R2 cDNA expression vector. Kits and computer program products are also described, wherein the kits provide materials for diagnosing and treating AF fibrosis, and the computer program products include a computer readable medium having computer readable program code for monitoring the efficacy of therapeutic ablation of fibrosis in a subject using a gene therapy method. | 02-06-2014 |
20140031508 | Enhancing the Physical Properties of Semi-Crystalline Polymers via Solid-State Shear Pulverization - Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties. | 01-30-2014 |
20140024922 | Curved Passive Acoustic Driver for Magnetic Resonance Elastography - An acoustic driver system includes an active acoustic driver and a passive acoustic driver. The active acoustic driver is configured to produce oscillating acoustic energy. The passive acoustic driver is acoustically connected to the active acoustic driver and is configured to receive the oscillating acoustic energy and to convert it into shear waves. The passive acoustic driver includes a housing member and a vibrating member. The housing member includes a housing member cavity. The vibrating member is disposed at least partially within the housing member cavity. The vibrating member permanently retains a curved shape while disposed within the housing member cavity. | 01-23-2014 |
20140023831 | Mesoscale pyramids, arrays and methods of preparation - Ordered, two-dimensional arrays of pyramidal particulates and related methods of preparation. | 01-23-2014 |
20140020745 | METAL OXIDE-ENCAPSULATED DYE-SENSITIZED PHOTOANODES FOR DYE-SENSITIZED SOLAR CELLS - Dye-sensitized semiconducting metal oxide films for photoanodes, photoanodes incorporating the films and DSCs incorporating the photoanodes are provided. Also provided are methods for making the dye sensitized semiconducting metal oxide films. The methods of making the films are based on the deposition of an encapsulating layer of a semiconducting metal oxide around the molecular anchoring groups of photosensitizing dye molecules adsorbed to a porous film of the semiconducting metal oxide. The encapsulating layer of semiconducting metal oxide is formed in such a way that it is not coated over the chromophores of the adsorbed dye molecules and, therefore, allows the dye molecules to remain electrochemically addressable. | 01-23-2014 |
20140015160 | Graphene Materials Having Randomly Distributed Two-Dimensional Structural Defects - Graphene-based storage materials for high-power battery applications are provided. The storage materials are composed of vertical stacks of graphene sheets and have reduced resistance for Li ion transport. This reduced resistance is achieved by incorporating a random distribution of structural defects into the stacked graphene sheets, whereby the structural defects facilitate the diffusion of Li ions into the interior of the storage materials. | 01-16-2014 |
20140013943 | Metal-Organic Frameworks for Xe/Kr Separation - Metal-organic framework (MOF) materials are provided and are selectively adsorbent to xenon (Xe) over another noble gas such as krypton (Kr) and/or argon (Ar) as a result of having framework voids (pores) sized to this end. MOF materials having pores that are capable of accommodating a Xe atom but have a small enough pore size to receive no more than one Xe atom are desired to preferentially adsorb Xe over Kr in a multi-component (Xe—Kr mixture) adsorption method. The MOF material has 20% or more, preferably 40% or more, of the total pore volume in a pore size range of 0.45-0.75 nm which can selectively adsorb Xe over Kr in a multi-component Xe—Kr mixture over a pressure range of 0.01 to 1.0 MPa. | 01-16-2014 |
20140011956 | Substrate-Independent Layer-By-Layer Assembly Using Catechol-Functionalized Polymers - The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surface-independent fashion is also provided. | 01-09-2014 |
20140011900 | Method for Producing Silyl-Functionalized Polyolefins and Silyl-Functionalized Polyolefins with Silyl Monomer Incorporation - Methods for producing a silyl-functionalized polyolefin with silyl monomer incorporation are provided. The method includes reacting a silicon-containing olefin with an α-olefin, in the presence of a catalytic amount of a group IV catalyst for a time sufficient to produce a silyl-functionalized polyolefin. | 01-09-2014 |
20140005428 | METAL-ORGANIC FRAMEWORK MATERIALS WITH ULTRAHIGH SURFACE AREAS | 01-02-2014 |
20140005258 | Delivery of Therapeutic Agents Using Oligonucleotide-Modified Nanoparticles as Carriers | 01-02-2014 |
20130345230 | METHODS AND COMPOSITIONS FOR MODULATING CALCIUM CHANNELS - The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions). | 12-26-2013 |
20130344392 | CRUMPLED GRAPHENE-ENCAPSULATED NANOSTRUCTURES AND LITHIUM ION BATTERY ANODES MADE THEREFROM - Capsules comprising crumpled graphene sheets that form a crumpled graphene shell encapsulating an internal cargo comprising nanostructures of a second component are provided. Also provided are anode materials for lithium ion batteries comprising the capsules, wherein the nanostructures are composed of an electrochemically active material, such as silicon. | 12-26-2013 |
20130344229 | SURFACE-INDEPENDENT, SURFACE-MODIFYING, MULTIFUNCTIONAL COATINGS AND APPLICATIONS THEREOF - The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality. | 12-26-2013 |
20130330837 | MONOCLONAL ANTIBODIES THAT TARGET PATHOLOGICAL ASSEMBLIES OF AMYLOID BETA (ABETA) - Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods utilizing such antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution. | 12-12-2013 |
20130330815 | Compositions, Devices And Methods For SERS And LSPR - The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax). | 12-12-2013 |
20130324869 | USING INTRACARDIAC ELECTROGRAMS TO PREDICT LOCATION OF FIBROSIS AND AUTONOMIC NERVES IN THE HEART - A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is described. The method includes at least the following steps. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue. | 12-05-2013 |
20130320971 | BIPOLAR MAGNETIC JUNCTION TRANSISTOR WITH MAGNETOAMPLIFICATION AND APPLICATIONS OF SAME - In one aspect of the present invention, the semiconductor device is a bipolar magnetic junction transistor (MJT), and includes a first non-magnetic semiconductor layer, a second non-magnetic semiconductor layer, and a magnetic semiconductor layer. The first non-magnetic semiconductor layer has majority charge carriers of a first polarity. The second non-magnetic semiconductor layer is disposed adjacent to the first non-magnetic semiconductor layer such that a first junction is formed at a first interface region between the first non-magnetic semiconductor layer and the second non-magnetic semiconductor layer. The magnetic semiconductor layer has majority charge carriers of the first polarity, and is disposed adjacent to the second non-magnetic semiconductor layer such that a second junction is formed at a second interface region between the second non-magnetic semiconductor layer and the magnetic semiconductor layer. | 12-05-2013 |
20130316954 | Methods of Treating Depression and Other Related Diseases - The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist. | 11-28-2013 |
20130310439 | METHOD OF REDUCING PROTEINS MISFOLDING AND/OR AGGREGATION - The present invention is directed to methods of reducing protein misfolding and/or aggregation in a subject and to method of treating a condition mediated by a dysfunction in protein homeostasis comprising modulating cholinergic signaling activity. | 11-21-2013 |
20130310323 | Methods of Treating Depression and Other Related Diseases - The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist. | 11-21-2013 |
20130303737 | TARGETED SCHIFF BASE COMPLEXES - The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof. | 11-14-2013 |
20130303530 | METHODS FOR TREATING CHRONIC PELVIC PAIN SYNDROME WITH ANTIBODIES THAT BINDS MCP-1 OR MIP-1A - The present invention provides methods and compositions for treating chronic pelvic pain syndrome. In particular, the present invention provides methods and compositions for treating chronic pelvic pain syndrome with an agent that targets MCP-1, MIP-1α, or the CCR-2 receptor. | 11-14-2013 |
20130302791 | DEVICE FOR ISOLATING AN ANALYTE FROM A SAMPLE, AND METHODS OF USE - A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described. | 11-14-2013 |
20130302787 | CARTRIDGE FOR USE IN AN AUTOMATED SYSTEM FOR ISOLATING AN ANALYTE FROM A SAMPLE, AND METHODS OF USE - A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample, is described. Methods of using the device are also described. Further processes, such as amplification of the isolated analyte, may also be carried out within the device. | 11-14-2013 |
20130302258 | MRI CONTRAST AGENTS - The present invention relates to MRI based imaging. In particular, the present invention provides MRI contrast agents targeted to a HaloTag protein with tunable relaxation properties thereby providing optimal relaxivity for low field strength imaging and the other optimal relaxivity for high field strength imaging. Moreover, the MRI contrast agents are used to detect gene expression (of a gene of interest) in real time in vivo, to detect changes in gene expression (of a gene of interest) over time in, for example, an individual organism, to detect gene expression changes (of a gene of interest) in response to therapeutics, in cell labeling for MR imaging, in clinical diagnostics, and in theranostics. | 11-14-2013 |
20130295367 | Composite polymer film with graphene nanosheets as highly effective barrier property enhancers - Composite polymer films or layers have graphene-based nanosheets dispersed in the polymer for the reduction of gas permeability and light transmittance. | 11-07-2013 |
20130287810 | VACCINE COMPOSITIONS AND USES THEREOF - The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendritic cells, resulting in a high level of humoral and acquired immunity, including both mucosal and systemic immunity. Such delivery systems find use in the specific delivery of a wide variety of oral vaccines to subjects. | 10-31-2013 |
20130252332 | SYNTHETIC PEPTIDE AND PEPTIDE CONJUGATES AND RELATED TISSUE COUPLING METHODS VIA TRANSGLUTAMINASE ENZYME - Peptides and conjugates thereof comprising one or more bioactive agents which can be coupled to a tissue via a transglutaminase and related methods. | 09-26-2013 |
20130237412 | Activation of Porous MOF Materials - A method for the treatment of solvent-containing MOF material to increase its internal surface area involves introducing a liquid into the MOF in which liquid the solvent is miscible, subjecting the MOF to supercritical conditions for a time to form supercritical fluid, and releasing the supercritical conditions to remove the supercritcal fluid from the MOF. Prior to introducing the liquid into the MOF, occluded reaction solvent, such as DEF or DMF, in the MOF can be exchanged for the miscible solvent. | 09-12-2013 |
20130236466 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-SURROGATES, ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 09-12-2013 |
20130233377 | LIQUID ELECTROLYTE-FREE, SOLID-STATE SOLAR CELLS WITH INORGANIC HOLE TRANSPORT MATERIALS - Photovoltaic cells incorporating the compounds A/M/X compounds as hole transport materials are provide. The A/M/X compounds comprise one or more A moieties, one or more M atoms and one or more X atoms. The A moieties are selected from organic cations and elements from Group 1 of the periodic table, the M atoms are selected from elements from at least one of Groups 3, 4, 5, 13, 14 or 15 of the periodic table, and the X atoms are selected from elements from Group 17 of the periodic table. | 09-12-2013 |
20130226232 | IMPROVED SUTURE - A medical device includes a surgical needle attached to a hollow tubular suture. The suture is constructed of macroporous hollow tubular wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility. | 08-29-2013 |
20130225634 | ANTI-CANCER COMPOUNDS - The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation. | 08-29-2013 |
20130224771 | ANTI-MULLERIAN HORMONE DETECTION IN WHOLE BLOOD - The present invention provides methods, kits, compositions, and devices for detecting Anti-Mullerian hormone (AMH) in whole blood samples. In certain embodiments, the methods, kits, compositions, and devices employ immunoassays that generate a colorimetric or fluorescent signal (e.g., using antibodies conjugated to gold nanoparticles or fluorescent particles) where the signal generated is proportional to the approximate concentration of AMH in a whole blood sample. In particular embodiments, the present invention provides quantitative or semi-quantitative lateral flow immunoassay devices and kits for detecting AMH at home (e.g., in order for women to estimate their ovarian age or diagnose polycystic ovarian syndrome). | 08-29-2013 |
20130224747 | Pathogenecity Islands of Pseudomonas Aeruginosa - Disclosed are | 08-29-2013 |
20130224633 | NANOSTRUCTURED CARBON ELECTRODE, METHODS OF FABRICATING AND APPLICATIONS OF THE SAME - Nanostructured carbon electrode usable for electrochemical devices and methods of fabricating the same. The method of fabricating a nanostructured carbon electrode includes providing a carbon material of large-effective-surface-area polyaromatic hydrocarbon (LPAH), mixing the carbon material of LPAH with a surfactant in a solution to form a suspension thereof; depositing the suspension onto a substrate to form a layered structure; and sintering the layered structure at a temperature for a period of time to form a nanostructured carbon electrode having a film of LPAH. | 08-29-2013 |
20130224153 | RECOMBINANT LACTOBACILLUS WITH DECREASED LIPOTEICHOIC ACID TO REDUCE INFLAMMATORY RESPONSES - Methods and compositions for treating or preventing inflammatory disorders are provided. The compositions of the invention comprise a recombinant bacterium genetically modified to decrease the display of lipoteichoic acid on the cell surface. Methods of the invention comprise administering to a subject a recombinant bacterium modified to decrease the display of lipoteichoic acid on the cell surface. Administration of the recombinant bacterium promotes a desired therapeutic response. The recombinant bacterium may be administered in a single dose or series of doses. Methods of the invention find use in treating or preventing a variety of inflammatory disorders including, for example, treating or preventing inflammatory bowel disease, colitis, or Crohn's disease. | 08-29-2013 |
20130222303 | HAPTIC DEVICE WITH INDIRECT HAPTIC FEEDBACK - A haptic device provides indirect haptic feedback and includes a substrate having a touch surface, a position sensor and a friction modulator associated with the substrate, wherein a coefficient of friction of the touch surface is modulated in response to a sensed position of relative to the touch surface and/or a derivative thereof. | 08-29-2013 |
20130217180 | Low-Temperature Fabrication of Metal Oxide Thin Films and Nanomaterial-Derived Metal Composite Thin Films - Disclosed are new methods of fabricating metal oxide thin films and nanomaterial-derived metal composite thin films via solution processes at low temperatures (<400° C.). The present thin films are useful as thin film semiconductors, thin film dielectrics, or thin film conductors, and can be implemented into semiconductor devices such as thin film transistors and thin film photovoltaic devices. | 08-22-2013 |
20130217124 | MODIFIED SILICA SHELL PARTICLES, AND METHODS OF MAKING AND USING THE SAME - Provided herein are silica shell particles modified on their surface with biomolecules, methods of making these particles, and methods of using these particles, e.g., in transfection methods, methods of inhibiting gene expression, and methods of delivering a therapeutic. | 08-22-2013 |
20130211500 | Liquid Cast Biodegradable Arterial Stent - Disclosed are liquid cast biodegradable arterial stents and methods for preparing liquid cast biodegradable arterial stents. The typically includes a biodegradable polymer and may include an agent for treating neointimal hyperplasia. | 08-15-2013 |
20130210050 | PROTEASE FOR PROTEOMICS - Provided herein is technology relating to proteases and proteomics and particularly, but not exclusively, to compositions comprising OmpT, methods of using OmpT, and methods of manufacturing OmpT for proteomics. | 08-15-2013 |
20130209999 | SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS - Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms of SQSTM1. | 08-15-2013 |
20130199605 | COMPOSITE OF GRAPHENE OXIDE AND NANOSTRUCTURES, METHODS OF MAKING AND APPLICATIONS OF SAME - A method of forming a graphene oxide based layer includes preparing a dispersion of graphene oxide and nanostructures, and spin coating the dispersion on a surface of a substrate to form a spin coated film thereon; and thermally annealing the spin coated film to form the graphene oxide based layer, where the mass ratio of the graphene oxide and the nanostructures in the graphene oxide based layer is in a range of about 1:0.01 w/w to 1:0.8 w/w. The nanostructures are functionalized with carboxylic acid. The nanostructures include carbon nanotubes, or nanofibers. The carbon nanotubes include single walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs). | 08-08-2013 |
20130196469 | Low-Temperature Fabrication of Metal Oxide Thin Films and Nanomaterial-Derived Metal Composite Thin Films - Disclosed are new methods of fabricating metal oxide thin films and nanomaterial-derived metal composite thin films via solution processes at low temperatures (<400° C.). The present thin films are useful as thin film semiconductors, thin film dielectrics, or thin film conductors, and can be implemented into semiconductor devices such as thin film transistors and thin film photovoltaic devices. | 08-01-2013 |
20130195828 | Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques - Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator. | 08-01-2013 |
20130195759 | NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL AND OTHER MOLECULES - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 08-01-2013 |
20130184144 | METHODS OF MAKING NON-COVALENTLY BONDED CARBON-TITANIA NANOCOMPOSITE THIN FILMS AND APPLICATIONS OF THE SAME - In one aspect, a method of making non-covalently bonded carbon-titania nanocomposite thin films includes: forming a carbon-based ink; forming a titania (TiO | 07-18-2013 |
20130183671 | ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4 - The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C). | 07-18-2013 |
20130174884 | ANISOTROPIC AMBIPOLAR TRANSVERSE THERMOELECTRICS AND METHODS FOR MANUFACTURING THE SAME - A transverse thermoelectric device includes a superlattice body, electrically conductive first and second contacts, and first and second thermal contacts. The superlattice body extends between opposite first and second ends along a first direction and between opposite first and second sides along a different, second direction. The superlattice body includes alternating first and second layers of crystalline materials oriented at an oblique angle relative to the first direction. The electrically conductive first contact is coupled with the first end of the superlattice and the electrically conductive second contact is coupled with the second end of the superlattice. The first thermal contact is thermally coupled to the first side of the superlattice and the second thermal contact is thermally coupled to the second side of the superlattice. A Seebeck tensor of the superlattice body is ambipolar. | 07-11-2013 |
20130172404 | Delivery of Oligonucleotide Functionalized Nanoparticles - The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle. | 07-04-2013 |
20130150560 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-SURROGATES, ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 06-13-2013 |
20130145242 | System and Method for Using Data and Angles to Automatically Generate a Narrative Story - A system and method for automatically generating a narrative story receives data and information pertaining to a domain event. The received data and information and/or one or more derived features are then used to identify a plurality of angles for the narrative story. The plurality of angles is then filtered, for example through use of parameters that specify a focus for the narrative story, length of the narrative story, etc. Points associated with the filtered plurality of angles are then assembled and the narrative story is rendered using the filtered plurality of angles and the assembled points. | 06-06-2013 |
20130144606 | System and Method for Using Data and Derived Features to Automatically Generate a Narrative Story - A system and method for automatically generating a narrative story receives data and information pertaining to a domain event. The received data and information and/or one or more derived features are then used to identify a plurality of angles for the narrative story. The plurality of angles is then filtered, for example through use of parameters that specify a focus for the narrative story, length of the narrative story, etc. Points associated with the filtered plurality of angles are then assembled and the narrative story is rendered using the filtered plurality of angles and the assembled points. | 06-06-2013 |
20130143768 | SYSTEM AND METHOD FOR GENERATING AND/OR SCREENING POTENTIAL METAL-ORGANIC FRAMEWORKS - A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage. | 06-06-2013 |
20130139686 | SYSTEM AND METHOD FOR GENERATING AND/OR SCREENING POTENTIAL METAL-ORGANIC FRAMEWORKS - A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage. | 06-06-2013 |
20130123333 | Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications - Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided. | 05-16-2013 |
20130123003 | AUTOMATIC DETECTION OF DEVIANT PLAYERS IN MASSIVELY MULTIPLAYER ONLINE ROLE PLAYING GAMES (MMOGS) - Gold farming refers to the illicit practice of gathering and selling virtual goods in online games for real money. Although around one million gold farmers engage in gold farming related activities, to date a systematic study of identifying gold farmers has not been done. Here data is used from the Massively Multiplayer Online Role Playing Game (MMOG) EverQuest II to identify gold farmers. This is posed as a binary classification problem and a set of features is identified for classification purposes. Given the cost associated with investigating gold farmers, criteria are also given for evaluating gold farming detection techniques, and suggestions provided for future testing and evaluation techniques. | 05-16-2013 |
20130122297 | MOLECULAR GAUGE BLOCKS FOR BUILDING ON THE NANOSCALE - Disclosed herein is a way to produce a series of discrete sized slender, rigid oligoparaxylene molecules ranging from 1-5 nm in length. Molecules, based on 1-7, 9-11 paraxylene rings, have been synthesized as part of a homologous series of oligoparaxylenes (OPXs) with a view to providing a molecular tool box for the construction of nano architectures—such as spheres, cages, capsules, metal-organic frameworks (MOFs), metal-organic polyhedrons (MOPs) and covalent-organic frameworks (COFs), to name but a few—of well-defined sizes and shapes. Twisting between the planes of contiguous paraxylene rings is generated by the steric hindrance associated with the methyl groups and leads to the existence of soluble molecular gauge blocks without the need—at least in the case of the lower homologues—to introduce long aliphatic side chains onto the phenylene rings in the molecules. | 05-16-2013 |
20130118958 | Purification of metal-organic framework materials - A method of purification of a solid mixture of a metal-organic framework (MOF) material and an unwanted second material by disposing the solid mixture in a liquid separation medium having a density that lies between those of the wanted MOF material and the unwanted material, whereby the solid mixture separates by density differences into a fraction of wanted MOF material and another fraction of unwanted material. | 05-16-2013 |
20130115254 | APTAMER-LOADED, BIOCOMPATIBLE NANOCONSTRUCTS FOR NUCLEAR-TARGETED CANCER THERAPY - Disclosed herein is a nanoconstruct comprising an aptamer and a gold nanostar. The nanoconstruct can be used in a method of inducing changes to a nuclear phenotype of a cell comprising transporting the nanoconstruct to a nucleus of a cell, and releasing the aptamer from a surface of the gold nanostar into the nucleus of the cell to afford deformations or invaginations in the nuclear membrane, thereby inducing changes to the nuclear phenotype. The method can be used to treat certain hyperproliferative disorders such as cancer. | 05-09-2013 |
20130109627 | ALKYLATED SP-C PEPTOID COMPOUNDS AND RELATED SURFACTANT COMPOSITIONS | 05-02-2013 |
20130108554 | CONTRAST AGENTS | 05-02-2013 |
20130103177 | SYSTEM AND METHOD FOR ACCUMULATIVE DOUBLE SIDED INCREMENTAL FORMING - A forming system includes first and second tools, moving assemblies, and a control unit. The moving assemblies move the first tool and the second tool relative to the sheet. The control unit is configured to control movement of the first tool and the second tool by the one or more moving assemblies by moving at least one of the first tool or the second tool in a first deformation direction to deform the sheet, then moving the first and second tools laterally relative to the sheet to a subsequent location while engaging the sheet, then moving at least one of the first tool or the second tool in the first deformation direction or an opposite second deformation direction to deform the sheet, and then continue moving the first and second tools to deform the sheet in order to create a three-dimensional component from the sheet. | 04-25-2013 |
20130101628 | NOVEL VEGF MIMETIC PEPTIDE-BASED SCAFFOLDS FOR THERAPEUTIC ANGIOGENESIS AND METHODS FOR THEIR USE - Disclosed herein is a completely synthetic cell-free therapy based on peptide amphiphile nanostructures designed to mimic the activity of vascular endothelial growth factor (VEGF), one of the most potent angiogenic signaling proteins. The VEGF-mimetic filaments disclosed herein were found to induce phosphorylation of VEGF receptors and induce pro-angiogenic behavior in endothelial cells, indicated by an enhancement in proliferation, survival and migration in vitro. | 04-25-2013 |
20130096694 | VACUUM PUMP SYSTEMS FOR PROSTHETIC LIMBS AND METHODS OF USING THE SAME - Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a mechanically activated pump having a first compression member coupled to a second compression member, a compressible bladder disposed between the first and second compression members, and coupling elements that engage and couple together the first and second compression members. The mechanically activated pump may be connected with an electrically activated pump within a fluid circuit of a hybrid pump system to provide vacuum engagement between a prosthetic device and a residual limb. | 04-18-2013 |
20130095519 | BIOLOGICAL TISSUE ANALYSIS BY INVERSE SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY - A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μ | 04-18-2013 |
20130078269 | AMYLOID BETA PEPTIDES, ASSEMBLIES THEREOF, AND RELATED METHODS - The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid β peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid β peptide subunits. | 03-28-2013 |
20130072496 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS - The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula I wherein R1, R4, R5, R6, R7, R8, R9, R12, R13 ET R14 are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioallyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfonyl, sulfinyl, sulfonyl, sultanate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, =0, ═S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications. | 03-21-2013 |
20130069010 | MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS - Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (α-complement), (ii) a molecular design of the second compound (β-complement), and (iii) a solvent system that promotes co-crystallization. | 03-21-2013 |
20130065833 | ALKYLATED SP-B PEPTOID COMPOUNDS AND RELATED LUNG SURFACTANT COMPOSITIONS - SP-B peptoid compounds, lung surfactant compositions and related surfactant replacement therapies. Such SP-B peptoids can mimic lung surfactant protein B, and can be used in conjunction with biomimetic SP-C compounds over a range of lung surfactant compositions. | 03-14-2013 |
20130064379 | AUDIO SEPARATION SYSTEM AND METHOD - A method includes determining a first spectrogram of the audio signal, defining a similarity matrix of the audio signal based on the first spectrogram and a transposed version of the first spectrogram, identifying two or more similar frames in the similarity matrix that are more similar to a designated frame than to one or more other frames in the similarity matrix, creating a repeating spectrogram model based on the two or more similar frames that are identified in the similarity matrix, and deriving a mask based on the repeating spectrogram model and the first spectrogram of the audio signal. The mask is representative of similarities between the repeating spectrogram model and the first spectrogram of the audio signal. The method also includes extracting a repeating structure from the audio signal by applying the mask to the audio signal. | 03-14-2013 |
20130063178 | LOGIC CELLS BASED ON SPIN DIODE AND APPLICATIONS OF SAME - In one aspect, the invention relates to logic cells that utilize one or more of spin diodes. By placing one or two control wires on the side of the spin diodes to generate magnetic fields in the spin diodes due to input currents, the logic cell can be changed from one logic gate to another logic gate. The unique feature leads to field logic devices in which simple instructions can be used to construct a whole new set of logic gates. | 03-14-2013 |
20130061752 | Tetratopic Phenyl Compounds, Related Metal-Organic Framework Materials and Post-Assembly Elaboration - Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation. | 03-14-2013 |
20130053758 | Triple Balloon Occlusion and Infusion Catheter - Disclosed are balloon catheters for forming liquid cast biodegradable arterial stents, typically, the balloon catheters include multiple balloons and multiple ports and include an element for promoting or initiating curing of a polymer solution via polymerization or cross-linking. | 02-28-2013 |
20130041290 | MEDICAL EVALUATION SYSTEM AND METHOD USING SENSORS IN MOBILE DEVICES - A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device carried by a patient at least when the patient is in a non-clinical environment. The processing module extracts medically relevant data from the sensory data received from the sensor in the mobile device. The relevant data includes one or more features of interest in the sensory data. The analysis module derives one or more surrogate biomarkers from the relevant data. The surrogate biomarkers represent at least one of a state or a progression of a medical condition of the patient. The mobile device may be a mobile phone carried by the patient and the sensor may include at least one of an accelerometer or a gyroscope that generates the sensory data to represent movements of the patient. | 02-14-2013 |
20130041169 | Neutral Bimetallic Transition Metal Phenoxyiminato Catalysts and Related Polymerization Methods - A catalyst composition comprising a neutral bimetallic diphenoxydiiminate complex of group 10 metals or Ni, Pd or Pt is disclosed. The compositions can be used for the preparation of homo- and co-polymers of olefinic monomer compounds. | 02-14-2013 |
20130041028 | METHODS OF USING (1S,3S)-3-AMINO-4-DIFLUOROMETHYLENYL-1-CYCLOPENTANOIC ACID - (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril). | 02-14-2013 |
20130040798 | Separation of single-walled carbon nanotubes by self-forming density gradient ultracentrifugation - The separation of single-walled carbon nanotubes (SWCNTs), by electronic type, using centrifugation of compositions of SWCNTs and surface active block copolymers in self-forming density gradient media. | 02-14-2013 |
20130040359 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition - Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition. | 02-14-2013 |
20130034845 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 02-07-2013 |
20130034599 | SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES - Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent. | 02-07-2013 |
20130029999 | MYOSIN LIGHT CHAIN KINASE INHIBITOR COMPOUNDS, COMPOSITIONS AND RELATED METHODS OF USE - Pyridazinyl compounds, compositions and related methods of use. | 01-31-2013 |
20130017332 | SUBSTRATE-INDEPENDENT LAYER-BY-LAYER ASSEMBLY USING CATECHOL-FUNCTIONALIZED POLYMERS - The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surface-independent fashion is also provided. | 01-17-2013 |
20130011340 | COMPOSITIONS AND METHODS COMPRISING MAGNETIC RESONANCE CONTRAST AGENTS - The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging. | 01-10-2013 |
20130004798 | CRUMPLED PARTICLES, METHODS OF SYNTHESIZING SAME AND APPLICATIONS USING SAME - In one aspect of the present invention, a method of for synthesizing compression- and aggregation-resistant particles includes forming a graphene dispersion solution with micron-sized graphene-based material sheets, nebulizing the graphene dispersion solution to form aerosol droplets, passing the aerosol droplets through a horizontal tube furnace pre-heated at a predetermined temperature by a carrier gas, and drying the aerosol droplets to concentrate and compress the micron-sized graphene-based material sheets into crumpled particles of sub-micron scale. | 01-03-2013 |
20120329882 | pH Responsive Self-Heating Hydrogels Formed By Boronate-Catechol Complexation - Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications. | 12-27-2012 |
20120326999 | TOUCH INTERFACE DEVICE AND METHOD FOR APPLYING LATERAL FORCES ON A HUMAN APPENDAGE - A touch interface device includes a touch surface configured to be engaged by an object, first and second actuator assemblies operably connected to the touch surface, and a controller operably connected with the first and second actuator assemblies. The first actuator assembly displaces the touch surface in one or more lateral directions along the touch surface at a first frequency. The second actuator assembly displaces the touch surface in an angled direction that is one of at least obliquely or perpendicularly angled to the touch surface at a second frequency. The controller operates the first and second actuator assemblies so that the touch surface varies in engagement with the object to impart a force on the object that is along the touch surface. | 12-27-2012 |
20120323270 | LEFT ATRIAL APPENDAGE OCCLUDER - Systems and methods for occluding a left atrial appendage are disclosed. A left atrial appendage may be covered with a first occluder device to obstruct the passage of blood out of the left atrial appendage. The first occluder device may include an expandable member, a cover attached to and covering an end of the expandable member, and a one-way valve disposed in the cover. The cover may form a flexible pocket between the cover and the expandable member. The cover may be made of bioprosthetic material. A second occluder device may also be disposed within the left atrial appendage by inserting the second occluder device through the one-way valve in the cover of the first occluder device. The second occluder device may be used to stretch the left atrial appendage to obliterate the left atrial appendage. | 12-20-2012 |
20120322155 | Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the Same - The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using a citric acid copolymers. | 12-20-2012 |
20120320368 | OPTICAL COHERENCE PHOTOACOUSTIC MICROSCOPY - A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the scanned light. The image processing module receives output from the detector and the transducer and generates a photoacoustic microscopy (PAM) image and an optical coherence tomography (OCT) image based on the received output from the detector and the transducer. The PAM and OCT image data may be fused to form a single, OC-PAM image. Additionally, a series of PAM images and OCT images, respectively, may be combined to generate three-dimensional PAM and OCT images, respectively. | 12-20-2012 |
20120319058 | SUPRAMOLECULAR NETWORKS WITH ELECTRON TRANSFER IN TWO DIMENSIONS - Organic charge-transfer (CT) co-crystals in a crossed stack system are disclosed. The co-crystals exhibit bidirectional charge transfer interactions where one donor molecule shares electrons with two different acceptors, one acceptor face-to-face and the other edge-to-face. The assembly and charge transfer interaction results in a pleochroic material whereby the optical absorption continuously changes depending on the polarization angle of incident light. | 12-20-2012 |
20120316115 | METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS - The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease. | 12-13-2012 |
20120309017 | PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 12-06-2012 |