NATIONAL UNIVERSITY OF SINGAPORE Patent applications |
Patent application number | Title | Published |
20160097063 | Production Of Enantiopure alpha-Hydroxy Carboxylic Acids From Alkenes By Cascade Biocatalysis - The invention provides compositions comprising an alkene epoxidase and a selective epoxide hydrolase, such as a recombinant microorganism comprising a first heterologous nucleic acid encoding an alkene epoxidase and a second heterologous nucleic acid encoding a selective epoxide hydrolase. Exemplary alkene epoxidases include StyAB, while exemplary selective epoxide hydrolases include epoxide hydrolases from | 04-07-2016 |
20160069874 | ASSAY DEVICE - The disclosure relates to a method and device for detecting and quantifying biological molecules such as cell surface or intracellular ligands/receptors in a dynamic system with high sensitivity and specificity; the method of using such platform optionally in combination with an optical detection system and kits comprising the optical platform. | 03-10-2016 |
20160056011 | ABERRATION CORRECTION APPARATUS, DEVICE HAVING THE SAME, AND METHOD FOR CORRECTING ABERRATION OF CHARGED PARTICLES - According to embodiments of the present invention, an aberration correction apparatus is provided. The aberration correction apparatus includes an aberration correction unit including a first conductive element, and a second conductive element arranged rotationally symmetrical about the first conductive element, wherein the aberration correction unit is arranged to propagate an annular beam having charged particles in between the first conductive element and the second conductive element such that propagation of the annular beam through the aberration correction unit is rotationally symmetrical about the first conductive element, and wherein the aberration correction unit is configured to generate, between the first conductive element and the second conductive element, a magnetic field force and an electric field force directed in opposite directions and superimposed on each other to act on the charged particles to change a trajectory of the charged particles, and an annular aperture optically coupled to the aberration correction unit. | 02-25-2016 |
20160030403 | Novel Dosing Regimens of Celgosivir for the Treatment of Dengue - Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV1-4 viral infections. | 02-04-2016 |
20160016116 | FORWARD OSMOSIS SYSTEM USING COORDINATION COMPLEXES - A forward osmosis system. The system contains a forward osmosis membrane, a draw solution, and a feed solution. The draw solution includes a coordination complex formed of a metal ion and an organic ligand coordinated to the metal ion. Also disclosed are a method of separating a liquid using such a forward osmosis system and a coordination complex used in this system. | 01-21-2016 |
20160002297 | THERAPEUTIC AGENTS - This disclosure relates to therapeutic agents comprising polypeptides and peptides that include the amino acid sequence motif arginine-lysine-aspartic acid [RKD] and their use in the treatment of conditions associated with abnormal angiogenesis. | 01-07-2016 |
20160000828 | A CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR USE IN CELL THERAPY AGAINST CANCER AND INFECTIOUS DISEASE - The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompasses methods for the use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases. | 01-07-2016 |
20150372541 | RECTENNA CIRCUIT ELEMENTS, CIRCUITS, AND TECHNIQUES FOR ENHANCED EFFICIENCY WIRELESS POWER TRANSMISSION OR AMBIENT RF ENERGY HARVESTING - A rectenna includes (a) a multi-band multi-channel (MBMC) matching network, and/or (b) an adaptively reconfigurable rectifier or a breakdown-protected rectifier. An MBMC matching network includes a plurality of T-shaped transmission line matching structures coupled in series. An adaptively reconfigurable rectifier circuit includes a low input power rectifying portion, a high high input power rectifying portion, and a set of transistors configured for selectively and automatically transitioning the adaptively reconfigurable rectifier between a low input power operating configuration and a high input RF power operating configuration, in a manner correlated with input RF power level. A breakdown-protected rectifier includes a transistor-protected diode structure having a diode coupled to a transistor in a manner that protects the diode from direct exposure to negative voltages that would ordinarily cause the diode to break down in the absence of the transistor. | 12-24-2015 |
20150368331 | ANGIOPOIETIN-RELATED PROTEIN 4 (CANGPTL4) AS A DIAGNOSTIC BIOMARKER FOR ACUTE LUNG DAMAGE - The invention relates to the C-terminal fragment of angiopoietin-related protein 4 [cAngptl4] as a diagnostic marker for viral and bacterial pneumonia; anti-angiopoietin-related protein 4 therapeutic antibodies, and the use of anti-angiopoietin-related protein 4 antibodies in the treatment of viral and bacterial pneumonia. | 12-24-2015 |
20150362413 | MICRODEVICES FOR SEPARATION OF NON-SPHERICAL PARTICLES AND APPLICATIONS THEREOF - The invention concerns at least one pillar in, or for use in, a microfluidic device wherein said pillar comprises, in cross-section, at least one particle abutment surface and an adjacent space that indents said pillar, or an adjacent groove that indents said pillar, to accommodate said particle; a plurality of such pillars arranged in an array; a method for separating particles in a fluid using said pillar, array or said device; and a diagnostic method involving the separation of particles from a fluid using said pillar, array or said device. | 12-17-2015 |
20150353821 | AN UPCONVERSION FLUORESCENT NANOPARTICLE - The present disclosure provides upconversion fluorescent nanoparticles comprising: a first nanocrystal layer, a second nanocrystal layer, and an energy absorbing layer disposed between the first nanocrystal layer and the second nanocrystal layer. There is also provided an article of manufacture comprising the upconversion fluorescent nanoparticles, as well as a bio-imaging and/or bio-detection apparatus comprising the upconversion fluorescent nanoparticles. The bio-imaging and/or bio-detection apparatus may further comprise a biomolecule and a source of excitation. | 12-10-2015 |
20150351967 | Bio-Absorbable Medicament-Eluting Ventilation Tube - The present disclosure relates to ventilation tubes used in the treatment of aural maladies such as, for example, otitis media. A bio-absorbable ventilation tube, optionally containing a medicament, is described for use in a land mammal. The bio-absorbable ventilation tube can be customized for both specific treatment and specific degradation rate based in part on the quantity and type of medicament added to a polymer forming the bio-absorbable ventilation tube. A method of preparing the bio-absorbable ventilation tube of the present disclosure is also provided. | 12-10-2015 |
20150351957 | PREVENTION & TREATMENT OF NEUROPATHY - The invention relates to the use of hypothermia to prevent or treat peripheral nerve neuropathy and including a system to induce optimized cooling of one or more body parts, typically the limbs. | 12-10-2015 |
20150335248 | METHODS RELATED TO REAL-TIME CANCER DIAGNOSTICS AT ENDOSCOPY UTILIZING FIBER-OPTIC RAMAN SPECTROSCOPY - A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods. | 11-26-2015 |
20150298102 | CATALYTIC HOLLOW FIBERS - A hollow fiber for use in production of hydrogen gas. The hollow fiber contains a porous support layer having an outer surface and an inner surface, a catalyst layer coated on the outer surface, and a selection layer coated on the inner surface. Also disclosed is a method of preparing such a hollow fiber. | 10-22-2015 |
20150291664 | BIOTINYLATED PROTEIN - The present invention relates to a fused protein. In particular, it relates to biotinylated protein comprising a protein selected from a group consisting of flavivirus structural and non-structural (NS) proteins. | 10-15-2015 |
20150290333 | PROCESS AND MATERIALS FOR MEDICAL APPLICATIONS - This disclosure relates to a fully or partially biodegradable carrier for the delivery of biologically active agents which are associated, either directly or indirectly, with the carrier via a biodegradable linking agent and the use of the carrier in the delivery of bioactive molecules for therapy and imaging, in particular the delivery of agents to mitochondria. | 10-15-2015 |
20150238363 | DEVICE FOR INSERTING AN IMPLANT AND METHOD OF USING THE SAME - In various embodiments, a device for inserting an implant on a human or animal body may be provided. The device may include an operable portion configured to make an incision on the human or animal body and configured to hold the implant for insertion on the human or animal body. The device may further include an actuator mechanism coupled to the operable portion, the actuator mechanism configured to move the operable portion along a first axis and configured to vibrate the operable portion along a second axis substantially perpendicular to the first axis. | 08-27-2015 |
20150234744 | FUSIBLE AND RECONFIGURABLE CACHE ARCHITECTURE - A reconfigurable cache architecture is provided. In processor design, as the density of on-chip components increases, a quantity and complexity of processing cores will increase as well. In order to take advantage of increased processing capabilities, many applications will take advantage of instruction level parallelism. The reconfigurable cache architecture provides a cache memory that in capable of being configured in a private mode and a fused mode for an associated multi-core processor. In the fused mode, individual cores of the multi-core processor can write and read data from certain cache banks of the cache memory with greater control over address routing. The cache architecture further includes control and configurability of the memory size and associativity of the cache memory itself. | 08-20-2015 |
20150229910 | METHOD AND APPARATUS FOR STEREOSCOPIC IMAGING - A device is disclosed that utilizes color or polarization to generate two separate images of the same object taken from the two perspectives that correspond to the left and right eyes of an observer. The two separate images are captured through a single camera objective (e.g., a single shutter camera), resulting in a single image with 3D information encoded in the color or polarization. Advantageously, the images are captured simultaneously, permitting obtaining stereoscopic images of both static and moving subjects, allowing 3D video capture. Examples include stereoscopic image acquisition devices that employ two or more image sensors, allowing for an acquisition of a high-definition image. For example, the device can include a trichroic prism and six image sensors, thus capturing left-eye and right-eye sets of color component images. | 08-13-2015 |
20150208103 | System and Method for Enabling User Control of Live Video Stream(s) - There is provided a system for enabling user control of a live video stream, the system including: a processing module for obtaining offset data for each of a plurality of encoded video segments having a number of different resolutions of the live video stream, the offset data indicative of offsets of video elements in the encoded video segment; a storage medium for storing the encoded video segments and the corresponding offset data; a segment management module for receiving messages from the processing module relating to the availability of the encoded video segments and facilitating streaming of the encoded video segments to the user based on said offset data; and a user interface module for receiving a user request from a user with respect to the live video stream and communicating with the segment management module for streaming the encoded video segments to the user based on the user request. There is also provided a corresponding method and a computer program product comprising instructions executable by a computing processor to perform the method. | 07-23-2015 |
20150203809 | CELL CULTURE - The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells. | 07-23-2015 |
20150155681 | Gate-Tunable Graphene-Ferroelectric Hybrid Structure for Photonics and Plasmonics - The invention relates to a novel type of gate-tunable photonics and plasmonics which utilizes doped large-scale graphene coupled with ferroelectric material. The graphene-ferroelectric hybrid structure paves the way for the realization of ultra-fast, low power consumption and multi-wavelength operation saturable absorbers for applications in ultra-fast laser systems and novel types of plasmonics for applications in infrared detection, single-photon quantum devices and ultrasensitive detectors. | 06-04-2015 |
20150148262 | MICROPARTICLE ASSEMBLY - A bead construct includes a bead, a fluorophore molecule, first and second linker molecules and a ligand molecule. The fluorophore molecule comprises at least two subunits connected to each other by at least one internal linker that provides conformational freedom to the at least two subunits. An optical signal emitted by the fluorophore molecule changes when reducing the conformational freedom of the at least two subunits to each other. The first linker molecule is connected to the bead and to one of the subunits of the flurophore molecule. The second linker molecule is connected to another one of the subunits of the fluorophore molecule. The ligand molecule is connected to the second linker molecule. | 05-28-2015 |
20150139943 | CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNE THERAPY - Disclosed herein are chimeric receptors comprising an extracellular domain with affinity and specific for the Fc portion of an immunoglobulin molecule (Ig) (e.g., an extracellular ligand-binding domain of F158 FCGR3A or V158 FCGR3A variant); a transmembrane domain (e.g., a transmembrane domain of CD8α); at least one co-stimulatory signaling domain (e.g., a co-stimulatory signaling domain of 4-1BB); and a cytoplasmic signaling domain comprising an immunoreceptor tyrosine-based activation motif (ITAM) (e.g., a cytoplasmic signaling domain of CD3ζ). Also provided herein are nucleic acids encoding such chimeric receptors and immune cells expressing the chimeric receptors. Such immune cells can be used to enhance antibody-dependent cell-mediated cytotoxicity and/or to enhance antibody-based immunotherapy, such as cancer immunotherapy. | 05-21-2015 |
20150105863 | FIBER-REINFORCED HYDROGEL COMPOSITES AND METHODS OF FORMING FIBER-REINFORCED HYDROGEL COMPOSITES - A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 μm. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, (ii) thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method (iii) using the fiber-reinforced composite are also provided. | 04-16-2015 |
20150085424 | SYNTHESIS OF THREE-DIMENSIONAL GRAPHENE FOAM: USE AS SUPERCAPACITORS - The invention relates to three-dimensional crystalline foams with high surface areas, high lithium capacity, and high conductivity for use as electrode materials and methods for their fabrication. In additional embodiments, the invention also relates to the use of three-dimensional crystalline foams as supercapacitors for improved charge and energy storage. | 03-26-2015 |
20150080802 | Novel Method To Fabricate Polymeric Microneedles - The present disclosure relates generally to microneedle devices and methods for fabricating microneedles from a biocompatible polymer using photolithography. More particularly, aspects of the present disclosure are directed to the fabrication of microneedle devices using a biocompatible polymer (biopolymer) by way of biocompatible, essentially biocompatible, or substantially biocompatible fabrication techniques. | 03-19-2015 |
20150050360 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CANCER - The present invention relates to a pharmaceutical composition comprising an anti-cancer drug and an inhibitor of bone morphogenetic protein 4 (BMP-4) or its gene expression. The present invention also relates to methods of treating cancer and prognostic methods. | 02-19-2015 |
20150044812 | NON-ACIDIC ISOTROPIC ETCH-BACK FOR SILICON WAFER SOLAR CELLS - A method for solar cell fabrication is provided. The method includes etching a doped surface of a silicon wafer solar cell using a solution including potassium hydroxide (KOH) and sodium hypochlorite (NaOCl). Alternatively the solution could include sodium hydroxide (NaOH) and NaOCl. In one aspect, the step of back-etching an emitter of the solar cell using the KOH:NaOCl solution is simultaneously performed with porous silicon removal. In another aspect, the step of back-etching the emitter of the solar cell using the KOH:NaOCl solution also includes PSG removal. And in yet another aspect, the step of back-etching the emitter of the solar cell using the KOH:NaOCl solution is performed simultaneously with polishing. | 02-12-2015 |
20150030662 | Generation of Brown Adipose Tissue (BAT) from Mesenchymal Cells - Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human brown adipocytes generated by the methods, and uses for the populations. Methods of generating functional human brown adipocytes in an individual, such as by administering a pharmaceutical composition comprising an differentiation cocktail, are also described. | 01-29-2015 |
20140357529 | Microarray and Method for Forming the Same - There is provided a microarray comprising a plurality of active agents immobilized onto an array of porous nanostructures, wherein each nanostructure has a network of pores that extends throughout the thickness of said nano structure. | 12-04-2014 |
20140346368 | GUN CONFIGURED TO GENERATE CHARGED PARTICLES - A gun configured to generate charged particles, comprising a ring-cathode ( | 11-27-2014 |
20140339168 | CERAMIC MEMBRANE CONTAINING CARBON NANOTUBES - A ceramic membrane for separating oil from water. The membrane contains a ceramic substrate having pore channels, and carbon nanotubes extending from surfaces of the ceramic substrate, wherein the ceramic substrate has a thickness of 0.1 to 50 mm and a porosity of 5 to 95%, the pore channels have a diameter of 0.001 to 20 μm, and the carbon nanotubes constitute 0.01 to 40% by weight. Also disclosed are a method of preparing this membrane and a method of using it. | 11-20-2014 |
20140335185 | NOVEL MICROCARRIER BEADS - The invention relates to a novel microcarrier bead; a method for producing same; a therapeutic comprising said microcarrier bead and attached thereto or grown thereon at least one selected cell or tissue type; a method for making said therapeutic; and a method of treatment involving the use of said microcarrier bead or said therapeutic. | 11-13-2014 |
20140328764 | Biocompatible Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes and Methods of Using the Same for In Vitro and In Vivo Imaging - The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging. | 11-06-2014 |
20140314723 | ENDOTHELIAL CELL CULTURE - The disclosure relates to cell culture vessels comprising fabricated cell culture surfaces providing means for efficient corneal endothelial cell growth and the use of the cultured cells in the repair of corneal tissue damage. | 10-23-2014 |
20140313470 | Thin-surface liquid crystal based voltage sensor - A method for fabricating a liquid crystal (LC) device and large area LC devices is provided. The method includes forming a LC layer and forming a coated silicon wafer on at least one surface of the LC layer. The coated silicon wafer includes a sacrificial layer for providing structural strength during fabrication of the LC device and a thin coating layer serving as an external light transmissive layer, and the coated silicon wafer is formed such that the thin coating layer is formed on the LC layer and the sacrificial layer is formed on the thin coating layer. The method also includes fabricating the LC device and selectively removing at least a portion of the sacrificial layer of the coated silicon wafer to expose at least a portion of the thin coating layer to serve as an external layer of the LC device. | 10-23-2014 |
20140305225 | APPARATUS AND METHOD FOR VISIOMETRIC DISINTEGRATION - In one version of the invention, an apparatus intended for determining the disintegration time of rapidly disintegrating tablets is designed with a disintegration cell having two liquid inlets and outflow from the top. Visualization of tablet inside the disintegration cell is conducted using a camera aided by a base light source and images captured using a computer or any other recording system. Disintegration medium is introduced into the disintegration cell through both inlets to produce a swirling motion and images of the tablet disintegration process are captured. The captured images are analyzed in real-time or off-line, to determine the tablet disintegration time. A visual non-recording method using projected image may also be used. | 10-16-2014 |
20140285632 | IMAGING DEVICE AND METHOD - An imaging system comprising an image capture apparatus, arranged to capture a stereoscopic image of an operator work site, in communication with a display system; the display system arranged to receive and display said stereoscopic image on a display screen to said operator; wherein said display system is arranged such that the display screen is placed intermediate the operator's eyes and the work site. | 09-25-2014 |
20140271563 | EFFECT OF AN ATTENUATED BORDETELLA STRAIN AGAINST ALLERGIC DISEASE - Described herein are compositions, vaccines, and methods that include use of a mutated | 09-18-2014 |
20140269177 | WING FOR WIDE TOW OF GEOPHYSICAL SURVEY SOURCES - Techniques are disclosed relating to wide towing of marine survey signal sources. In one embodiment, an apparatus includes a signal source and a wing coupled to the signal source. In this embodiment, the wing is configured to impart a force to the signal source when towed through a body of water by a survey vessel. In this embodiment, the force includes a lateral component and a vertical component. The wing may be configured to impart the force based on a shape of the wing and an orientation of the wing. The wing may extend over at least a third of a length of a keel of the apparatus. At least a majority of a top surface of the wing may be oriented within 20 degrees of parallel to a surface of the body of water. The wing may include a plurality of wing sections. | 09-18-2014 |
20140255430 | METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA - The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus. | 09-11-2014 |
20140244228 | CODON OPTIMIZATION OF A SYNTHETIC GENE(S) FOR PROTEIN EXPRESSION - The present disclosure is related to a method of optimization of a nucleotide coding sequence coding for an amino acid sequence, wherein the nucleotide coding sequence is optimized for expression in a host cell. The present disclosure also relates to system for optimizing a nucleotide coding sequence coding for an amino acid sequence, wherein the nucleotide coding sequence is optimized for expression in a host cell. | 08-28-2014 |
20140232582 | ANALOG-TO-DIGITAL CONVERTER FOR A MULTI-CHANNEL SIGNAL ACQUISITION SYSTEM - An analog-to-digital converter (ADC) for a multi-channel signal acquisition system, a signal acquisition system, a method of generating a digital output code from an analog input signal, and a method of converting a plurality of analog signals to a digital signal are provided. The ADC comprises a sample-and-hold (S/H) circuit operable to receive an analog input signal for each input channel; a digital-to-analog converter (DAC) common to all input channels; a comparator for each input channel configured to receive an output signal from the S/H circuit of the respective input channel, and an output signal from the DAC, for generating a comparison result of the two signals at each conversion cycle of the comparator; and a successive approximation register (SAR) common to all input channels and configured to generate, for each input channel, a digital output code based on the comparison results received from the respective comparator. | 08-21-2014 |
20140231270 | METHODS OF NONDESTRUCTIVELY DELAMINATING GRAPHENE FROM A METAL SUBSTRATE - Methods of delaminating a graphene film ( | 08-21-2014 |
20140220448 | PRODUCTION OF NANOSTRUCTURED LI4TI5O12 WITH SUPERIOR HIGH RATE PERFORMANCE - A process of preparing nanostructured lithium titanate particles. The process contains the steps of providing a solvent containing a soft-template compound, a lithium ion-containing compound, and a titanium ion-containing compound; removing the solvent to obtain a lithium titanate precursor; and calcining the precursor followed by milling and annealing. Also disclosed is a nanostructured lithium titanate particle prepared by this process. | 08-07-2014 |
20140218478 | METHOD AND APPARATUS FOR STEREOSCOPIC IMAGING - A device is disclosed that utilizes color or polarization to generate two separate images of the same object taken from the two perspectives that correspond to the left and right eyes of an observer. The two separate images are captured through a single camera objective (e.g., a single shutter camera), resulting in a single image with 3D information encoded in the color or polarization. Advantageously, the images are captured simultaneously, permitting obtaining stereoscopic images of both static and moving subjects, allowing 3D video capture. The device can be an attachment to a conventional, single shutter, image capturing device, such as a camera, a smart phone with a camera feature, computer with a camera feature, and so on. | 08-07-2014 |
20140199330 | PROTEIN INVOLVED IN DETECTION OF CANCER METASTASIS AND A TREATMENT THEREOF - Using phosphoproteomics, we profiled the phosphorylation levels of hundreds of proteins concurrently across an isogenic model of breast cancer metastasis. Among them is TRPV4, a calcium channel that we found to be overexpressed in invasive breast tumors compared to ductal carcinoma in situ, a pre-neoplastic lesion and normal tissues. TRPV4 was also found to be elevated mostly in invasive breast cancer cell lines and less so in non-invasive breast cancer cell lines. These data led us to hypothesize that TRPV4 confer early traits of metastatic cancer cells. Functional studies revealed that silencing of TRPV4 expression diminished breast cancer cell migration and invasion significantly but not proliferation. Silencing expression of TRPV4 in metastatic breast cancer cells also reduced the number and size of metastatic colonies in mice. This supports the notion that TRPV4 is an attractive drug target to curb metastasis. Further experimentations suggested that the functional effect of TRPV4 on breast cancer cellular processes was associated with regulation of intracellular Ca2+, cell plasticity and expression of cell-cell adhesion proteins such as beta-catenin and E-cadherin. The latter two events have obvious implications in cancer invasion and intravasation/extravasation. We have also made novel observations that activation of TRPV4 by PDD led to activation of AKT and FAK pathways, both shown to be important to cell migration. In particular, downregulation of E-cadherin and b-catenin following TRPV4 activation has been shown to be mediated by the AKT pathway. Collectively, our data suggest that activation of Ca2+ dependent cascades and pathways associated with cell migration mediate TRPV4 function in breast cancer metastasis. | 07-17-2014 |
20140193626 | TRANSPARENT CONDUCTOR - A transparent conductor comprising: a graphene layer and a permanent dipole layer on the graphene layer configured to electrostatically dope the graphene layer. | 07-10-2014 |
20140190550 | TANDEM SOLAR CELL WITH GRAPHENE INTERLAYER AND METHOD OF MAKING - A tandem solar cell with graphene interlayer and method of making are disclosed. The graphene interlayer can serve as a recombination contact to a pair of photoactive subcells electrically connected in series or as a common electrode to a pair of photoactive subcells electrically connected in parallel. The highly conducting, transparent nature, and easily modifiable chemical and electrical properties of a graphene interlayer enable tunable energy matching to the photoactive subcells. Using different photoactive subcells that can harvest light across the solar spectrum results in a tandem solar cell that can achieve high power conversion efficiency. | 07-10-2014 |
20140188135 | Bio-Absorbable Micro-Clip And Applicator For Minimal Access Wound Closure - The present disclosure includes a bio-absorbable wound closure clip for wound closure without crushing of the tissue being closed. The bio-absorbable wound closure clip can be used in minimal access surgery as well as on tissue, such as mucosal tissue, where tactile feedback is reduced. Representative surgical instruments for applying the bio-absorbable wound closure clip and methods of using the same are also provided herein. | 07-03-2014 |
20140178735 | REDOX FLOW BATTERY SYSTEM - A redox flow battery system having an electrochemical cell and an energy reservoir. The system includes a cathodic compartment, an anodic compartment, a separator that divides the two compartments, and an energy reservoir which contains an electro-active material, electro-active ions, an electrolyte, and a redox mediator. The reservoir is connected to either the cathodic compartment or the anodic compartment via an inlet-outlet pair for circulating the electrolyte from the energy reservoir to the cathodic compartment or the anodic compartment. | 06-26-2014 |
20140175381 | TUNNELING TRANSISTOR - Devices and methods for forming a device are presented. The device includes a substrate and a fin type transistor disposed on the substrate. The transistor includes a fin structure which serves as a body of the transistor. The fin structure includes first and second end regions and an intermediate region in between the first and second end regions. A source region is disposed on the first end region, a drain region disposed in the second end region and a gate disposed on the intermediate region of the fin structure. The device includes a channel region disposed adjacent to the source region and a gate dielectric of the gate. A source tunneling junction is aligned to the gate with a controlled channel thickness T | 06-26-2014 |
20140163963 | Methods and Systems for Automated Text Correction - The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. In a particular embodiment, the single text correction model may be generated through analysis of both a corpus of learner text and a corpus of non-learner text. | 06-12-2014 |
20140163641 | MUSCLE STIMULATION SYSTEM - According to one aspect of the invention, there is provided a muscle stimulation system for effecting appendage movement, the muscle stimulation system comprising: first transceiver circuitry; at least one first implantable stimulation device for implantation adjacent to one or more first muscles responsible for the appendage movement, the first implantable stimulation device configured to be wirelessly activated by the first transceiver circuitry; second transceiver circuitry; at least one second implantable stimulation device for implantation adjacent to one or more second muscles responsible for the appendage movement, the second implantable stimulation device configured to be wirelessly activated by the second transceiver circuitry; and a base station configured to wirelessly communicate with both the first transceiver circuitry and the second transceiver circuitry to receive and transmit signals that causes coordinated activation of the first implantable stimulation device and/or the second implantable stimulation device to coordinate stimulation of the first muscles and/or the second muscles that are responsible for the appendage movement. | 06-12-2014 |
20140154303 | TREATING CANCER BY INHIBITING EXPRESSION OF OLFM4, SP5, TOB1, ARID1A, FBN1 OR HAT1 - The present invention in one aspect relates to a method for treating cancer or enhancing a cancer treatment, the method comprising inhibiting the expression of an oligonucleotide encoding for a protein selected from the group consisting of OLFM4, SP5, TOB1, ARID1A, FBN1 and HAT1, by administering to a mammal in need of cancer treatment an effective amount of at least one silencing oligonucleotide comprising a binding motif for binding to the oligonucleotide encoding for a protein. | 06-05-2014 |
20140148358 | SYSTEM AND METHOD FOR DETECTING ONE OR MORE ANALYTES IN A FLUID - Various embodiments provide a system for detecting one or more analytes in a fluid. The system comprises: a controller adapted to obtain one or more sample streams of the fluid. The controller is configured in use to form a plurality of output streams. Each output stream comprises at least part of one of the one or more sample streams. The system further comprises: a detector adapted to receive from the controller the plurality of output streams and comprising a plurality of sensors. Each sensor is operable to detect an interaction between a corresponding detecting agent and a corresponding analyte. The detector is configured in use to detect one or more said interactions using the plurality of output streams to determine if the fluid contains one or more said analytes. A corresponding method is also provided. | 05-29-2014 |
20140147377 | PHOTOCATALYST FOR WATER SPLITTING - A nanocrystalline photocatalyst for water splitting and a method for fabricating a nanocrystalline photocatalyst for water splitting. The photocatalyst comprises a structure having a specific surface area and a volume fraction of atoms located both on the surface and at the grain boundaries adapted for enhancement of a photocatalytic reaction. | 05-29-2014 |
20140141997 | FOETAL NUCLEATED RED BLOOD CELL DETECTION - In one aspect, the invention is directed to methods of separating foetal nucleated red blood cells (FNRBCs) from a sample comprising contacting the sample with an agent that specifically recognizes CD147, thereby producing a mixture; maintaining the mixture under conditions in which a complex forms between the agent and the CD147 in the sample; and separating the complex from the mixture; thereby separating the FNRBCs from the sample. In other embodiments, the invention is directed to methods of detecting FNRBCs in a sample comprising contacting the sample with an antibody or antigen binding fragment thereof that specifically binds CD147, thereby producing a combination; maintaining the combination under conditions in which an immune complex forms between the antibody and FNRBCs present in the sample; and detecting whether the immune complex forms in the combination; wherein if the immune complex is detected then FNRBCs are present in the sample. In still other aspects, the invention further comprises methods of separating FNRBCs from anucleated RBCs, detecting prenatal disorders and/or the gender of a foetus. | 05-22-2014 |
20140134490 | APPROACH FOR MANUFACTURING EFFICIENT MESOPOROUS NANO-COMPOSITE POSITIVE ELECTRODE LiMn1-xFexPO4 MATERIALS - A process of preparing mesoporous nano-composite LiMn | 05-15-2014 |
20140128743 | HIGH SENSITIVITY TEMPORAL FOCUSING WIDEFIELD MULTIPHOTON ENDOSCOPE CAPABLE OF DEEP IMAGING - An imaging system is provided that includes a pulsed light source providing pulsed light and is applicable to both microscopes and endoscopes. One or more optical elements with certain dispersive properties are positioned to receive the pulsed light and apply selective dispersive properties to shift the focal plane according to the user and to produce two photon (2p) wide field uniform illumination and 2p wide field structured illumination for the purpose of improving the optical axial resolution and rejection of background signal. An imaging element receives the signal arising from the 2p wide field uniform illumination and 2p wide field structured illumination and produces a respective 3D resolved image of a sample. | 05-08-2014 |
20140121129 | Alkylamino BODIPY Dyes As Selective Fluorescent Probes For Proteins And Mouse Embryonic Stem Cells - The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line. | 05-01-2014 |
20140120615 | Methods of Freezing Stem Cells - The invention is directed to a method of freezing stem cells comprising introducing the HSCs into a cell culture medium that has been conditioned with Wharton's Jelly mesenchymal stem cells (WJSCs), thereby producing a stem cell culture, and slowly freezing the stem cell culture. In other aspects, the invention is directed to compositions comprising stem cells produced by the methods provided herein. In yet other aspects, the invention is directed to pharmaceutical compositions comprising the stem cells produced by the methods provided herein. | 05-01-2014 |
20140113196 | SYNTHESIS OF MESOPOROUS TRANSITION METAL OXIDES AS ANODE MATERIALS - A method of preparing mesoporous nanostructured particles of a transition metal oxide. The method contains the steps of dissolving a soft-template compound in a solvent, dispersing a first or second row transition metal ion-containing compound, adjusting the pH value if necessary, and removing the solvent to obtain mesoporous nanostructured transition metal oxide powders, calcining the powders optionally to afford mesoporous nanostructured particles of the transition metal oxide. Also disclosed is particle prepared by the above-described method. | 04-24-2014 |
20140097841 | SPINWAVE BASED NONDESTRUCTIVE MATERIAL, STRUCTURE, COMPONENT, OR DEVICE TESTING TOOLS - Systems and methods for spinwave-based metrology in accordance with embodiments of the disclosure involve generating and detecting spinwaves in a sample having a ferromagnetic material; and determining a material thickness, a material integrity measure, a presence of a manufacturing defect, a categorical type of manufacturing defect, and/or a manufacturing process statistic corresponding to spinwave behavior in the sample. In an embodiment, spinwaves are generated by way of concurrent exposure of a target measurement site of the sample to each of a bias magnetic field and radiation (e.g., microwave or radio frequency radiation) produced by a first set of integrated waveguides. A response signal corresponding to a behavior of spinwaves within the target measurement site can be generated by way of a second set of integrated waveguides. Various embodiments of systems and methods for generating spinwaves, detecting spinwaves, and calculating, analyzing, or monitoring one or more sample properties can be automated. | 04-10-2014 |
20140087456 | Isolating Target Cells From A Biological Fluid - A micro-fluidic device operable to isolate target cells from a biological fluid comprises: an inlet operable to receive the biological fluid, the biological fluid comprising target cells and other components; a waste outlet operable to receive at least the other components of the biological fluid; a plurality of parallel arrays of cell isolation wells coupling the inlet with the waste outlet, each parallel array of cell isolation wells supporting a flow of the biological fluid from the inlet to the waste outlet in response to a pressure differential thereacross, each array of cell isolation wells comprising a plurality isolation wells, each isolation well being dimensioned to mechanically trap the target cells therein whilst permitting flow of other components of the biological fluid; and at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of the plurality of parallel arrays of cell isolation wells. | 03-27-2014 |
20140087191 | Method of Transferring Thin Films - The present invention discloses a method for transferring a thin film from a first substrate to a second substrate comprising the steps of: providing a transfer structure and a thin film provided on a surface of a first substrate, the transfer structure comprising a support layer and a film contact layer, wherein the transfer structure contacts the thin film; removing the first substrate to obtain the transfer structure with the thin film in contact with the film contact layer; contacting the transfer structure obtained with a surface of a second substrate; and removing the film contact layer, thereby transferring the thin film onto the surface of the second substrate. | 03-27-2014 |
20140077134 | IMPLANTATION OF NI NANO DOMAINS IN REFRACTORY METAL OXIDE SUPPORT BY MEANS OF SOL-GEL ENCAPSULATION - AN EFFECTIVE SOLUTION TO COKE FORMATION IN THE PARTIAL OXIDATION OF NATURAL GAS - A metal oxide-supported nickel catalyst includes a matrix containing a metal oxide and catalytic sites distributed throughout the matrix and having an intricate interface with the matrix, in which the catalytic sites are selected from the group consisting of nano-nickel(0) domains and nano-nickel(0)-A(0) alloy domains. Also disclosed are a method for preparing this catalyst and a method for using it to produce carbon monoxide and hydrogen by partial oxidation of a C | 03-20-2014 |
20140072610 | BIOABSORBABLE TRACHEAL STENT, AND METHOD OF MANUFACTURING THEREOF - A bioabsorbable tracheal stent is provided. The bioabsorbable stent comprises a biodegradable polymer, wherein the “ biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. A drug is dispersed within or dissolved in the biodegradable polymer. In a second and third aspect, the invention relates to methods of manufacturing a bioabsorbable tracheal stent. The first method includes forming a solution comprising a biodegradable polymer and a drug, the biodegradable polymer comprising about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. The method further comprises casting the solution to form the bioabsorbable tracheal stent. The second method includes forming a polymeric stent, and dip casting the polymeric stent in a solution comprising a biodegradable polymer and a drug to form a coating on the polymeric stent, wherein the biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. | 03-13-2014 |
20140045721 | Microarray System and a Process for Producing Microarrays - A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on differences between each image. Also disclosed in a system for using the microarray. | 02-13-2014 |
20140042317 | PARALLEL RADIAL MIRROR ANALYSER FOR SCANNING MICROSCOPES - A parallel radial mirror analyser (PRMA) ( | 02-13-2014 |
20140030724 | METHOD OF IDENTIFYING, ISOLATING AND/OR CULTURING FOETAL ERYTHROBLASTS - There is provided a method of identifying at least one foetal erythroblast in a sample, the method comprising analysing the morphology of at least one cell in the sample; wherein at least one analysed cell that is nucleated, is CD45 negative and comprises a relatively high cytoplasmic to nuclear ratio is identified as the foetal erythroblast. | 01-30-2014 |
20140029801 | In-Video Product Annotation with Web Information Mining - A system provides product annotation in a video to one or more users. The system receives a video from a user, where the video includes multiple video frames. The system extracts multiple key frames from the video and generates a visual representation of the key frame. The system compares the visual representation of the key frame with a plurality of product visual signatures, where each visual signature identifies a product. Based on the comparison of the visual representation of the key frame and a product visual signature, the system determines whether the key frame contains the product identified by the visual signature of the product. To generate the plurality of product visual signatures, the system collects multiple training images comprising multiple of expert product images obtained from an expert product repository, each of which is associated with multiple product images obtained from multiple web resources. | 01-30-2014 |
20140007265 | CHIMERIC GENE CONSTRUCTS FOR GENERATION OF FLUORESCENT TRANSGENIC ORNAMENTAL FISH | 01-02-2014 |
20140004046 | Pericyte Progenitors From Peripheral Blood | 01-02-2014 |
20130341177 | REGENERATIVE ADSORPTION DISTILLATION SYSTEM - There is provided a regenerative adsorption distillation system comprising a train of distillation effects in fluid communication with each other. The train of distillation effects comprises at least one intermediate effect between the first and last distillation effects of the train, each effect comprising a vessel and a condensing tube for flow of a fluid therein. The system further comprises a pair of adsorption-desorption beds in vapour communication with the last effect and at least one intermediate effect, wherein the beds contain an adsorbent that adsorbs vapour from the last effect and transmits desorbed vapour into at least one of the intermediate effect. | 12-26-2013 |
20130337500 | SYSTEM AND METHOD FOR ISOLATION OF CELLS - In accordance with an embodiment of the invention, there is provided a microfluidic device for isolating cells from a biological fluid. The device comprises an inlet receiving the biological fluid flowed into the device, and at least one array of a plurality of isolation wells receiving the biological fluid from the inlet. At least one isolation well of the plurality of isolation wells comprises a cell trap of a size and shape suitable to mechanically isolate a cell within the cell trap. The cell trap comprises at least one gap of a size and shape suitable to prevent passage of the cells to be isolated but to permit passage of other components of the biological fluid through the cell trap. | 12-19-2013 |
20130331360 | MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT - The invention is directed to a method of administering hydrogen sulfide (H | 12-12-2013 |
20130330055 | Apparatus, System, and Method for Annotation of Media Files with Sensor Data - Embodiments of methods for multimedia annotation with sensor data (referred to herein as Sensor-rich video) includes acquisition, management, storage, indexing, transmission, search, and display of video, images, or sound, that has been recorded in conjunction with additional sensor information (such as, but not limited to, global positioning system information (latitude, longitude, altitude), compass directions, WiFi fingerprints, ambient lighting conditions, etc.). The collection of sensor information is acquired on a continuous basis during recording. For example, the GPS information may be continuously acquired from a corresponding sensor at every second during the recording of a video. Therefore, the acquisition apparatus generates a continuous stream of video frames and a continuous stream of sensor meta-data values. The two streams are correlated in that every video frame is associated with a set of sensor values. Note that the sampling frequency (i.e., the frequency at which sensor values can be measured) is dependent on the type of sensor. For example, a GPS sensor may be sampled at 1-second intervals while a compass sensor may be sampled at 50 millisecond intervals. Video is also sampled at a specific rate, such as 25 or 30 frames per second. Sensor data are associated with each frame. If sensor data has not changed from the previous frame (due to a low sampling rate) then the previously measured data values are used. The resulting combination of a video and a sensor stream is called a sensor-rich video. | 12-12-2013 |
20130329281 | INVERSE OPAL STRUCTURES AND METHODS FOR THEIR PREPARATION AND USE - Light-reflective structures comprising a binding material configured as an inverse opal having reflections of at least two wavelengths and methods of producing the light-reflective structures are described herein. The wavelengths reflected by the light-reflective structures may be tuned by external stimuli. In an example, silk-fibroin inverse opals have two reflection wavelengths that may be shifted based on changes in humidity. | 12-12-2013 |
20130325442 | Methods and Systems for Automated Text Correction - The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. In a particular embodiment, the single text correction model may be generated through analysis of both a corpus of learner text and a corpus of non-learner text. | 12-05-2013 |
20130324533 | METHOD OF DETECTING RESISTANCE TO CANCER THERAPY - We describe a polymorphic variant of a BIM {BCL2L11) gene which comprises, in 5′ to 3′ order, the nucleotide sequence set out in SEQ ID NO: 5 followed immediately by the nucleotide sequence set out in SEQ ID NO: 7. The BIM polymorphic variant may be characterised by lacking the nucleotide sequence set out in SEQ ID NO: 6. It may be used to detect BCR-ABL-independent TKI-resistance (resistance to treatment with tyrosine kinase inhibitors) for chronic myelogenous leukaemia, c-KIT/PDGFR-independent TKI-resistance for gastrointestinal stromal tumours (GIST), EGFR-independent TKI-resistance for non-small cell lung cancer (NSCLC) or JAK2-independent TKI-resistance for a myeloproliferative disorder, in an individual comprising such a polymorphism. | 12-05-2013 |
20130320254 | METHOD OF FABRICATING GRADED MEDIA - A magnetic data storage medium comprising: an ion doped magnetic recording layer having a continuous grading of coercivity or anisotropy, wherein the coercivity or anisotropy is at a minimum substantially at one side of the magnetic recording layer, and having substantial portion of maximum coercivity or anisotropy at the other side of the magnetic recording layer. Also, a method of fabricating a magnetic data storage medium is included. | 12-05-2013 |
20130309237 | Pathogenic Mycobacteria-Derived Mannose-Capped Lipoarabinomannan Antigen Binding Proteins - Described herein are antigen binding proteins that bind to pathogenic mycobacteria-derived Mannose-Capped Lipoarabinomannan (ManLAM) and methods and kits for using and making the antigen binding proteins. Also described herein are antigen binding proteins that bind to the alpha 1-2 linkage mannose caps of ManLAM, antigen binding proteins that bind to a mannose cap with up to three alpha 1-2 linked mannose residues, and antigen binding proteins that bind to LAM with a mannose sugar capping motif. | 11-21-2013 |
20130307935 | IMAGING SYSTEM AND METHOD - There is provided an imaging system comprising image capture apparatus and display apparatus. The image capture apparatus is for capturing an image of an operator work site, the image including depth information. The display apparatus is in communication with the image capture apparatus, and comprises at least one display screen. The display apparatus is arranged to receive the image captured by the image capture apparatus, including the depth information, and display to the operator the image captured by the image capture apparatus, including the depth information, on the display screen. The display screen is located between the operator's eyes and the position of the work site. There is also provided a method for capturing and displaying an image of an operator work site. | 11-21-2013 |
20130306551 | HIGH PERFORMANCE POSITIVELY CHARGED COMPOSITE MEMBRANES AND THEIR USE IN NANOFILTRATION PROCESSES - The present invention is directed to positively charged nanofiltration (NF) membranes comprising a substrate layer (S) based on a sulfonated polymer and a positively charged film layer (F) on top of said substrate, and to a method for their preparation. Furthermore, the present invention is directed to nanofiltration processes making use of said composite membrane. | 11-21-2013 |
20130305920 | Preparation of Zeolitic Imidazolate Frameworks (ZIFs) - Polybenzimidazole Mixed-Matrix Composite and Application for Gas and Vapor Separation - The present invention presents a mixed-matrix composite material comprising a continuous phase and zeolitic imidazolate framework (ZIF) particles dispersed in the continuous phase, wherein the continuous phase is polybenzimidazole (PBI), methods for making the mixed-matrix composite material, and methods for separating gas or vapor from a mixture of gases or vapors using the mixed-matrix composite material. | 11-21-2013 |
20130302285 | Wharton's Jelly Mesenchymal Stem Cells and Uses Thereof - In one aspect, the invention is directed to methods of expanding hematopoietic stem cells (HSCs) comprising culturing the HSCs with Wharton's Jelly mesenchymal stem cells (WJSCs), a cell culture medium that has been conditioned with WJSCs, or a combination thereof, thereby producing a HSC culture; and maintaining the HSC culture under conditions in which the HSCs expand in the culture, thereby expanding the HSCs. In another aspect, the invention is directed to a method of transplanting the expanded HSCs in an individual in need thereof. In yet another aspect, the invention is directed to compositions comprising HSCs and Wharton's Jelly mesenchymal stem cells (WJSCs). The composition can further comprise a cell culture medium that has been conditioned with WJSCs. | 11-14-2013 |
20130277318 | ULTRAFILTRATION MEMBRANES FABRICATED FROM SULFONATED POLYPHENYLENESULFONES - The present invention is directed to ultrafiltration membranes comprising a membrane substrate layer (S) based on a sulfonated polyaryleneethersulfone polymer and to a method for their preparation. Furthermore, the present invention is directed to ultrafiltration processes making use of said membrane. | 10-24-2013 |
20130273345 | Non-linear Optical Response Materials - An optical-limiter is disclosed herein. In an embodiment, the optical limiter comprises chemically functionalized graphene substantially spaced apart as single sheets in a substantially transparent liquid cell or solid thin film. A method of fabricating an optical response material is also disclosed. | 10-17-2013 |
20130273056 | TYROSINE-PHOSPHORYLATED WBP2, A NOVEL CANCER TARGET AND BIOMARKER - WW-binding protein 2 (WBP2) has been demonstrated in different studies to be a tyrosine kinase substrate, to activate ERα/PR transcription and to play a role in breast cancer. However, the role of WBP2 tyrosine phosphorylation in regulating ER function and breast cancer biology is unknown. Here, we established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk. Using dominant negative, constitutively active mutants, RNAi and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases. We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity putatively by blocking nuclear entry of WBP2 and its interaction with ERα. Compared to vector control, overexpression of WBP2 and its phospho-mimic mutant in MCF7 resulted in larger tumors in mice, induced loss of cell-cell adhesion, enhanced cell proliferation, anchorage-independent growth, migration and invasion in both estrogen-dependent and-independent manner, events of which could be substantially abolished by overexpression of phosphorylation-defective mutant. Wnt/β-catenin inhibitor FH535 blocked phospho-WBP2-mediated cancer cell growth more pronouncedly than tamoxifen and fulvestrant, in part by reducing the expression of ERα. | 10-17-2013 |
20130259871 | Human Monoclonal Antibody with Specificity for Dengue Virus Serotype 1 E Protein and Uses Thereof - Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate, or prevent relapse from infection. | 10-03-2013 |
20130252294 | PRODUCTION OF INDUSTRIALLY RELEVANT COMPOUNDS IN PROKARYOTIC ORGANISMS - Disclosed herein are methods for producing compounds (such as 3,4-dihydroxybenzoate, catechol, cis,cis-muconate, or β-carboxy-cis,cis-muconic acid) utilizing biosynthetic pathways in prokaryotic organisms expressing one or more heterologous genes. In some embodiments, the method includes expressing a heterologous asbF gene (for example, a gene having dehydroshikimate dehydratase activity) in a prokaryotic cell under conditions sufficient to produce the one or more compounds and purifying the compound. In additional embodiments, the method further includes expressing one or more of a heterologous 3,4-DHB decarboxylase gene, a heterologous catechol 1,2-dioxygenase gene, and a heterologous 3,4-DHB dioxygenase gene in the prokaryotic cell and purifying the compound. | 09-26-2013 |
20130249094 | METHOD OF PREPARING TRANSPARENT CONDUCTING OXIDE FILMS - The present invention discloses a method of preparing a transparent conducting oxide (TCO) film comprising the steps of: applying surface modified TCO nanoparticles onto a surface of a substrate; and cross-linking the surface modified TCO nanoparticles. The present invention also provides a transparent conducting oxide film prepared according to the method. | 09-26-2013 |
20130247756 | UV-REARRANGED PIM-1 POLYMERIC MEMBRANES AND A PROCESS OF PREPARING THEREOF - The present invention relates to UV-rearranged PIM-1 polymeric membranes that can be used for advanced hydrogen purification and production. The present invention also relates to a process of preparing UV-rearranged PIM-1 polymeric membranes. The present invention further relates to a method of separating gas mixtures using the UV-rearranged PIM-1 polymeric membranes of the present invention. | 09-26-2013 |
20130224790 | Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe - The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. | 08-29-2013 |
20130224710 | ROBOTIC DEVICE FOR USE IN IMAGE-GUIDED ROBOT ASSISTED SURGICAL TRAINING - A robotic device for use in image-guided robot assisted surgical training, the robotic device comprising a manual interface structure configured to simulate handling of a surgical tool; a translational mechanism for translational motion of the manual interface structure; a rotational mechanism for rotational motion of the manual interface structure; and a spherical mechanism configured to decouple the orientation of the manual interface structure into spatial coordinates, wherein a linkage between the rotational mechanism, the rotational mechanism and the spherical mechanism, and the manual interface structure are disposed on opposing sides of an intersection of a pitch axis and a yaw axis of the spherical mechanism. | 08-29-2013 |
20130217889 | NOVEL PHASE TRANSFER CATALYSTS - Compounds of formula (I): wherein R | 08-22-2013 |
20130215406 | LITHOGRAPHY METHOD AND APPARATUS - A lithography method and apparatus is disclosed herein. In a described embodiment, the method comprises (i) providing a first mask having an exposure pattern for forming a three dimensional structure; (ii) exposing the first mask to radiation to form the exposure pattern on a radiation-sensitive resist; the exposure pattern defined by irradiated areas and non-irradiated areas of the resist; (ii) providing a second mask; and (iii) during exposure, changing relative positions between the first mask and the second mask to shield selected portions of the irradiated areas from radiation to enable varying depth profiles to be created in the three dimensional structure. | 08-22-2013 |
20130204392 | METHOD FOR PROMOTING STEM CELL CHONDROGENESIS - There is provided a method for promoting stem cell chondrogenesis, comprising the step of culturing a population of stem cells on a plurality of imprints disposed on a substrate, the imprints being configured to selectively promote chondrogenesis of the stem cells. | 08-08-2013 |
20130197038 | Compositions And Methods For Neovascularization - The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1α (HIF-1α). In another aspect, the invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1α (HIF-1α) and one or more lysophospholipids. In addition, the invention is directed to methods of generating prevascularized tissue, methods of generating a vascular network in a device and compositions thereof. | 08-01-2013 |
20130196300 | ROBOT ASSISTED SURGICAL TRAINING - A surgical training system and method. The system comprises means for recording reference data representing a reference manipulation of a computer generated model of an object by a master user; means for physically guiding a trainee user based on the recorded reference data during a training manipulation of the model of the object by the trainee user; and means for recording assessment data representing an assessment manipulation of the model of the object by the trainee user without guidance. | 08-01-2013 |
20130195904 | HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) HIGHLY CONSERVED AND LOW VARIANT SEQUENCES AS TARGETS FOR VACCINE AND DIAGNOSTIC APPLICATIONS - We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV-1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation. | 08-01-2013 |
20130189727 | Methods And Compositions For Cellular Imaging And Cancer Cell Detection Using Light Harvesting Conjugated Polymer-Biomolecular Conjugates - The invention is a compound represented by any one of Structural Formulas (I)-(IV), or a salt thereof, wherein the values and alternative values for the variables are as defined in the Detailed Description of the Invention. Methods using a compound of Structural Formula (I)-(IV), or a salt thereof, are also presented. | 07-25-2013 |
20130183237 | THROMBIN INHIBITOR - The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites. | 07-18-2013 |
20130180336 | VIBRATION DETECTOR AND METHOD - A vibration detector ( | 07-18-2013 |
20130177915 | MODIFIED STEM-LOOP OLIGONUCLEOTIDE MEDIATED REVERSE TRANSCRIPTION AND BASE-SPACING CONSTRAINED QUANTITATIVE PCR - There is provided a method for detecting a target RNA molecule in a sample. The method comprises reverse transcribing the target RNA contained in the sample using an RT oligonucleotide, the RT oligonucleotide comprising a stem-loop portion containing one or more nucleotides modified or modifiable to block DNA polymerase extension and a target annealing portion that is complementary to a downstream portion of the target RNA, the target annealing portion located 3′ to the stem-loop portion, to produce a reverse transcription product that comprises the RT oligonucleotide and a 3′ extended region; amplifying the reverse transcription product using (i) a first amplification primer that anneals to a downstream portion of the 3′ extended region of the reverse transcription product and (ii) a second amplification primer that anneals to an interface portion of a DNA strand complementary to the reverse transcription product, the interface portion comprising a region that is complementary to a 3′ portion of the RT oligonucleotide and a 5′ portion of the 3′ extended region in the reverse transcription product, to produce an amplification product; and detecting the amplification product; wherein the stem-loop portion adopts a stem-loop structure under conditions used for said reverse transcribing but does not adopt the stem-loop structure under conditions used for said amplifying and wherein when the stem-loop portion contains one or more nucleotides that are modifiable to block DNA polymerase extension, the method further comprises modifying the modifiable nucleotide prior to said amplifying. | 07-11-2013 |
20130163119 | Head-Media Interface in a Hard Disk Drive - A hard disk drive comprising a mixed layer is provided to reduce the head-media spacing in the hard disk drive by embedding a surface of a magnetic recording medium or head of the hard disk drive with energetic ions. The mixed layer provides sufficient protection against corrosion and wear of the magnetic layer of the magnetic recording medium without requiring any DLC and/or lubricant overcoat. | 06-27-2013 |
20130163117 | Surface Treatment Method to Develope a Durable Wear Resistant Overcoat for Magnetic Recording Systems - A durable wear-resistant coating consists of an atomically mixed layer on the surface of the head or media which is developed by bombardment of the surface with energetic C ions with optimized parameters. This mixed layer is covered with a hard DLC overcoat. This mixed interlayer is able to strongly bond the overcoat to the head or media substrate and improve the tribological properties of the overcoat. In this method a very thin layer of a carbide former material can be used as an interlayer before bombarding the surface with C ions which provides a composite interlayer containing C and species from interlayer and substrate. This composite interlayer strongly bonds the DLC overact to the ceramic substrate of the head or the metallic substrate of the media. This interlayer by itself is protective enough to protect the head media of the hard drives against wear and corrosion. | 06-27-2013 |
20130143123 | MESOPOROUS METAL PHOSPHATE MATERIALS FOR ENERGY STORAGE APPLICATION - Mesoporous particles each including LiFePO | 06-06-2013 |
20130130951 | SU-8 NANO-COMPOSITES WITH IMPROVED TRIBOLOGICAL AND MECHANICAL PROPERTIES - Substantially homogenous compositions in accordance with the present disclosure can exist in various forms, such as bulk materials, coatings, films, laminates, inserts, or overlays, and include at least one polymer such as SU-8, at least one liquid lubricant, and optionally at least one nanomaterial that serves as an inorganic filler material. Such compositions exhibit enhanced tribological and mechanical properties compared to the at least one polymer in isolation, for instance, a 50% or greater coefficient of friction reduction, a 100% or greater wear life increase, a 10% or greater elastic modulus increase, and/or a 10% or greater hardness increase. The at least one nanomaterial can include a first nanomaterial providing increased hardness, and a second nanomaterial providing increased elastic modulus. Compositions in accordance with the present disclosure are suitable for biological and non-biological applications. | 05-23-2013 |
20130126730 | SEQUENTIAL RADIAL MIRROR ANALYSER - A sequential radial mirror analyser (RMA) ( | 05-23-2013 |
20130118775 | METAL NANOWIRES, NANOMESH, AND A METHOD OF FABRICATION - The present invention relates to a method of forming copper nanowires with a metallic coating. In a preferred embodiment, the metallic coating is copper. Due to the metal coating, the nanowires become magnetically guidable and chemically stable. As such, the nanowires can be used to form nanomesh. Further, the nanowire and nanomesh of the present invention can be used as transparent electrodes that are used in TV, PC, touch-control, and solar industries. | 05-16-2013 |
20130109029 | Methods And Compositions For Cellular Imaging And Cancer Cell Detection Using Light Harvesting Conjugated Polymer-Biomolecular Conjugates | 05-02-2013 |
20130105384 | THIN FILM COMPOSITE OSMOSIS MEMBRANES | 05-02-2013 |
20130102805 | POROUS CERAMIC MATRIX - A porous ceramic matrix contains a plurality of ceramic particles adhered to each other, and a plurality of channels defined by surfaces of neighbouring ceramic particles, the channels each having an average diameter of 0.5-2.5 μm. Preferred ceramics also have a porosity of 25.0-40.0%, a Darcy's Permeability of 1.57-34.8×10 | 04-25-2013 |
20130101578 | BIOMARKER FOR RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES - The invention provides kits and methods for the diagnosis, prognosis, and treatment of reduced kidney function in patients, such as diabetic patients. The methods include a step of detecting one or more nephrin degradation products in a sample from the subject, such as a urine sample. | 04-25-2013 |
20130101517 | DEVELOPMENT OF PHOTOSTABLE NEAR-IR CYANINE DYES FOR IN VIVO IMAGING - A compound of structural formula (I): | 04-25-2013 |
20130095083 | Method For Controlling And Accelerating Differentiation Of Stem Cells Using Graphene Substrates - The invention relates to methods for directing differentiation of stem cells comprising graphene. In additional embodiments, the invention relates to methods for repairing and improving bone tissue functions comprising accelerating differentiation in stem cell growth by exposing stem cells to graphene and transplanting the graphene with the exposed stem cells in the tissue at the site of repair. | 04-18-2013 |
20130085497 | Articulating Ablation And Division Device With Blood Flow Sensing Capability - A laparoscopic liver resection device is described. The device combines the Radiofrequency Ablation (RFA) technology with a cutting mechanism, a blood-flow sensor and a flexible actuation mechanism to simultaneously coagulate and cut the liver tissue and detect the presence of blood flow to confirm avascularity. The present invention eliminates the risk of excess bleeding due to cutting too deep and reduces recovery time and the time spent on re-coagulation of coagulated areas, thereby shortening duration of surgery. Also embodiments prevent excess ablation by stopping ablation activity on the target tissue as soon as insufficient or no blood flow in the target tissue is detected. Thus a closed loop control for a bloodless tissue/organ division method is provided. | 04-04-2013 |
20130071629 | METHOD OF APPLYING A LUBRICANT TO A MICROMECHANICAL DEVICE - According to an embodiment of the present invention, a method of applying a lubricant to a micromechanical device is provided. The method includes: positioning a dispensing portion of a lubricant liquid dispenser over a surface portion of a micromechanical device; and controlling the dispenser such that a single lubricant liquid droplet of a predefined volume is forced out of the dispensing portion and impinges onto the surface portion. | 03-21-2013 |
20130065751 | IMPLANTATION OF NI NANO DOMAINS IN REFRACTORY METAL OXIDE SUPPORT BY MEANS OF SOL-GEL ENCAPSULATION - AN EFFECTIVE SOLUTION TO COKE FORMATION IN THE PARTIAL OXIDATION OF NATURAL GAS - A metal oxide-supported nickel catalyst includes a matrix containing a metal oxide and catalytic sites distributed throughout the matrix and having an intricate interface with the matrix, in which the catalytic sites are selected from the group consisting of nano-nickel(0) domains and nano-nickel(0)-A(0) alloy domains. Also disclosed are a method for preparing this catalyst and a method for using it to produce carbon monoxide and hydrogen by partial oxidation of a C | 03-14-2013 |
20130053730 | Miniature Sensor Tip for Medical Devices and Method of Forming the Same - According to embodiments of the present invention, a micro-sensory tip for use in blood vessels is provided. The micro-sensory tip includes: a force transmission element; at least three force detecting sensors coupled to the force transmission element, each of the at least three force detecting sensors responsive to force applied on the force transmission element, wherein each of the at least three force detecting sensors produces an output representing at least one force component of a three-dimensional Cartesian co-ordinate system, of the force experienced by the force transmission element, such that the outputs of the at least three force detecting sensors can cover the space of the three-dimensional Cartesian co-ordinate system; and an active element arrangement coupled to the at least three force detecting sensors, the active element arrangement configured to process the output from the at least three force detecting sensors. | 02-28-2013 |
20130048952 | HOLE DOPING OF GRAPHENE - An article includes a layer of graphene having a first work function; and a metal oxide film disposed on the layer of graphene, the metal oxide film having a second work function greater than the first work function. Electrons are transferred from the layer of graphene to the metal oxide film, forming a hole accumulation layer in the layer of graphene. | 02-28-2013 |
20130046057 | POLYIMIDE MEMBRANES AND THEIR PREPARATION - Disclosed are (1) a method of preparing a polyimide membrane, including cross-linking polyimides via thermal labile side chains and decomposition of the thermal labile side chains; and (2) polyimide membranes thus prepared. | 02-21-2013 |
20130042670 | DETERMINATION OF PORE SIZE IN POROUS MATERIALS BY EVAPORATIVE MASS LOSS - A method for determination of pore-size distribution in a porous material called evapo porometry (EP) is capable of determining pore sizes from approximately the nanometer scale up to the micron scale. EP determines the pore size based on the evaporative mass loss at constant temperature from porous materials that have been pre-saturated with either a wetting or non-wetting volatile liquid. The saturated porous material is placed in an appropriate test cell on a conventional microbalance to measure liquid mass loss at a constant temperature as a function of time. The mass-loss rate is then related to the pore-size distribution. The microbalance permits measuring the mass as a function of time. The slope of the mass versus time curve is the evaporation rate. The evaporation rate is related to the vapor pressure at the interface between the liquid in the porous material and the ambient gas phase. The vapor pressure in turn is related to the pore diameter. | 02-21-2013 |
20130003258 | SUPERHYDROPHILIC AND WATER-CAPTURING SURFACES - A coated substrate includes a substrate and a coating containing a water insoluble polymer and a water soluble polymer, the two polymers, due to different water affinity, forming a nanosegregant on the substrate. Also disclosed are a method of preparing the above-described coated substrate and the use of this coated substrate in a solid-state supercapacitor. | 01-03-2013 |
20120323016 | METHOD OF PREPARING DERIVATIVES/OLIGOMERS OF EPICATECHIN AND APPLICATIONS THEREOF - The present invention relates to the preparation of a class of novel, optically active compounds derived from oligomeric proanthocyanidins (OPCs), more particularly to oligomers of epicatechin. These compounds include multidentate ligands and their metal complexes for use in catalysis. Methods of depolymerising proanthocyanidins to form catechins, and particularly depolymerising proanthocyanidins derived from plant sources to form novel epicatechins having application in catalysis are disclosed. | 12-20-2012 |
20120308580 | HEPATITUS B VIRUS SPECIFIC ANTIBODY AND USESE THEREOF - There is provided at least one isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one HBV derived peptide. | 12-06-2012 |
20120301423 | FUNCTIONALISED ANTIFOULING COMPOUNDS AND USE THEREOF - The present invention relates to derivatives of α,α-disubstituted amide compounds which comprise a substituted aryl at the α carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, es ters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalised so as to include or be formed from the substituted compound can be used to reduce settlement. | 11-29-2012 |
20120294879 | CONSENSUS SEQUENCE FOR INFLUENZA A VIRUS - Pandemic A(H1N1) continues its global spread, and vaccine production is a serious problem. Protection by current vaccines is limited by the mutational differences that rapidly accumulate in the circulating strains, especially in the virus surface proteins. New vaccine strategies are focusing at conserved regions of the viral internal proteins to produce T cell epitope-based vaccines. T cell responses have been shown to reduce morbidity and promote recovery in mouse models of influenza challenge. We previously reported 54 highly conserved sequences of NP, M1 and the polymerases of all human H1N1, H3N2, H1N2, and H5N1, and avian subtypes over the past 30 years. Sixty-three T cell epitopes elicited responses in HLA transgenic mice (A2, A24, B7, DR2, DR3 and DR4). These epitopes were compared to the 2007-2009 human H1N1 sequences to identify conserved and variant residues. Seventeen T cell epitopes of PB1, PB2, and M1 were selected as vaccine targets by analysis of sequence conservation and variability, functional avidity, non-identity to human peptides, clustered localization, and promiscuity to multiple HLA alleles. The vaccines composed of these epitopes, being highly conserved and temporally stable, would be useful for any avian or human influenza A virus. | 11-22-2012 |
20120273423 | COMPOSITE MEMBRANES COMPRISING A SULFONATED POLYARYLETHER AND THEIR USE IN FORWARD OSMOSIS PROCESSES - The present invention is directed to thin film composite membrane (TFC membrane) comprising a substrate layer (S) based on a sulfonated polymer, e.g. a sulfonated polyarylether, and a polyamide film layer (F) and further to a method for their preparation. Furthermore, the present invention is directed to osmosis processes, in particular to forward osmosis (FO) processes, using said membrane. | 11-01-2012 |
20120264125 | SCREENING METHOD FOR TRINUCLEOTIDE REPEAT SEQUENCES - A method for screening for a trinucleotide repeat sequence in a biological sample is provided. The method comprises the step of contacting a nucleic acid sequence obtained or derived from the biological sample under amplification conditions with i) a first primer having a target sequence in a region 3′ or 5′ of a trinucleotide repeat sequence; ii) a second primer having a target sequence within the trinucleotide repeat sequence and a unique 5′ tail sequence; and iii) a third primer, having a target within the unique 5′ tail sequence of the second primer to generate an amplified product comprising a trinucleotide repeat sequence. Primers, kits of primers together with the use of the primers in methods of screening are also provided. | 10-18-2012 |
20120243180 | ENHANCED HEAT SINK - A heat sink device for dissipating heat from an electronic component mounted thereto, the device comprising: an inlet for receiving a fluid; an outlet for venting said fluid; a heat dissipation zone intermediate the inlet and outlet; said zone including a plurality of transverse channels and a plurality of oblique channels extending between adjacent transverse channels; wherein said oblique and transverse channels define a fluid path for said fluid from the inlet to the outlet. | 09-27-2012 |
20120226145 | TRANSCUTANEOUS ROBOT-ASSISTED ABLATION-DEVICE INSERTION NAVIGATION SYSTEM - A robotic system for overlapping radiofrequency ablation (RFA) in tumor treatment is disclosed. The robot assisted navigation system is formed of a robotic manipulator and a control system designed to execute preoperatively planned needle trajectories. Preoperative imaging and planning is followed by interoperative robot execution of the ablation treatment plan. The navigation system combines mechanical linkage sensory units with an optical registration system. There is no requirement for bulky hardware installation or computationally demanding software modules. Final position of the first needle placement is confirmed for validity with the plan and then is used as a reference for the subsequent needle insertions and ablations. | 09-06-2012 |
20120219531 | Microcarriers for Stem Cell Culture - The present application discloses a method of generating bone tissue in vivo comprising implanting cells into a human or animal at a location where bone growth is required, wherein the cells have been obtained by the in vitro suspension culture of mesenchymal stem cells attached to microcarriers. | 08-30-2012 |
20120218653 | LIGHT-REFLECTIVE STRUCTURES AND METHODS FOR THEIR MANUFACTURE AND USE - Light-reflective materials and methods for their preparation and use are described. The materials can have multiple particles or voids arranged in a crystal structure. The materials can reflect various types of light such as visible light, ultraviolet light, or infrared light. | 08-30-2012 |
20120190125 | WATER-SOLUBLE SILSESQUIOXANES AS ORGANIC QUANTUM DOTS FOR SENSING AND IMAGING - This invention includes a compound represented by the following structural formula (I) or an acceptable salt thereof. | 07-26-2012 |
20120190050 | CANCER BIOMARKER AND THE USE THEREOF - Gastric cancer is one of the leading causes of cancer-related death worldwide. To date no specific marker is available for gastric cancer screening. The expression profile of 37 proteins was identified to be consistently different between the plasma of normal and gastric cancer subjects. The expression of complement component C9 protein was validated to be significantly higher in the plasma of gastric cancer compared to normal subjects. This was independent of the gastritis and | 07-26-2012 |
20120167241 | CHIMERIC GENE CONSTRUCTS FOR GENERATION OF FLUORESCENT TRANSGENIC ORNAMENTAL FISH - Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5′ end of the EGFP gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used. Thus, new varieties of ornamental fish of different fluorescence patterns, e.g., skin fluorescence, muscle fluorescence, skeletal muscle-specific and/or ubiquitous fluorescence, are developed. | 06-28-2012 |
20120121647 | INFLUENZA VACCINE, COMPOSITION, AND METHODS OF USE - The invention relates to compositions and vaccines that include a mutated | 05-17-2012 |
20120089117 | APPARATUS THAT INCLUDES NANO-SIZED PROJECTIONS AND A METHOD FOR MANUFACTURE THEREOF - An apparatus that includes a nano-projection array and an application unit configured to displace the nano-projection array to thereby deliver a composition (e.g., vaccine) to a controlled depth within the skin. The nano-projection array includes nano-projections carried by a carrier substrate. The application unit includes a peripheral structure and a displaceable carrier. The nano-projection array can be disposed within the peripheral structure. Displacement of the displaceable carrier causes a corresponding displacement to the nano-projection array. The displacement of the displaceable carrier can be controlled. For instance the distance of displacement of the displaceable carrier can be controlled. A method or process for manufacturing the apparatus is also provided. | 04-12-2012 |
20120077792 | LANTHANIDE METAL COMPLEXES USEFUL IN TREATING CANCER - The present invention relates to a compound of formula (I). Provided is also a method of killing a cell that comprises administering the compound of formula (I). Provided is also a method of treating cancer or diabetes in a mammal that comprises administering the compound of formula I and respective pharmaceutical compositions thereof. | 03-29-2012 |
20120028269 | Methods For Detection Of Gastric Cancer - The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the individual and comparing the expression level to a control, wherein an increase in the expression level of ITIH3 in the individual compared to the control is indicative of gastric cancer in the individual. | 02-02-2012 |
20120018699 | METHOD OF ZINC OXIDE FILM GROWN ON THE EPITAXIAL LATERAL OVERGROWTH GALLIUM NITRIDE TEMPLATE - A growth method is proposed for high quality zinc oxide comprising the following steps: (1) growing a gallium nitride layer on a sapphire substrate around a temperature of 1000° C.; (2) patterning a SiO | 01-26-2012 |
20120015923 | USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS - We describe for the first time that andrographolide derivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-?B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma. | 01-19-2012 |
20120015922 | USE OF ARTEMISININ DERIVATIVES FOR THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) - Artesunate is a derivative of artemisinin isolated from a Chinese herb | 01-19-2012 |
20120003259 | MOLECULE - We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed. | 01-05-2012 |
20110311745 | CHEMICALLY-MODIFIED POLYBENZIMIDAZOLE MEMBRANOUS TUBES - This invention relates to a chemically-modified polybenzimidazole porous tube. The tube has an outer diameter of 100-1000 microns, a wall thickness of 20-100 microns, and a pore size of 0.1-0.5 nm. | 12-22-2011 |
20110291953 | ROBOT DEVICE AND PLATFORM FOR SOCIAL NETWORKING - A small microcontroller based robotic toy includes various rich features on its small footprint. User input sensing includes a smooth scrolling enabled resistive or capacitive touch sensing pad primarily for child-friendly menu navigation. Pressure activated squeeze areas of the robot surface facilitate exchange of special gifts and emoticons through a network. Additionally, the robotic toy allows a user to experience a multimodal engagement visually via a miniature OLED graphics display, audibly by an embedded audio system for producing sounds and through haptics using a vibrotactile effects generator. | 12-01-2011 |
20110277631 | METHOD FOR MODIFYING A POLYIMIDE MEMBRANE - There is provided a method for modifying a polyimide membrane comprising the step of exposing the polyimide membrane to a surface modification compound in a vapour phase, said surface modification compound having at least one amine group, to thereby modify the polyimide membrane. | 11-17-2011 |
20110269812 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES - The present invention relates generally to organic chemistry, biochemistry, pharmacology and medicine. More particularly, it relates to 3-benzylidene-indolin-2-one derivatives and their physiologically acceptable salts and prodrugs which modulate the activity of protein kinases (“PKs”), especially protein tyrosine kinase, and, therefore, are expected to exhibit a salutary effect against disorders related to abnormal PK activity. The present invention is further directed to methods of using of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of protein kinase-mediated diseases and disorders, such as cancer. | 11-03-2011 |
20110234488 | PORTABLE ENGINE FOR ENTERTAINMENT, EDUCATION, OR COMMUNICATION - To simplify human-machine interaction, a portable interaction module includes multiple channels through which input is received. Different types of input mechanisms or sensors allow use of multiple techniques for capturing input, such as motion sensing, audio sensing, image tracking, image sensing, or physiological sensing. A fusion module included in the portable input device receives data from the input mechanisms or sensors and generates an input description identifying which input mechanisms or sensors receive data. The input description is communicated to a target device, which determines an output corresponding to the input description. Using multiple input capture techniques simplifies interaction with the target device by providing a variety of methods for obtaining input. | 09-29-2011 |
20110215277 | METHOD OF SYNTHESIZING COLLOIDAL NANOPARTICLES - There is provided a method for synthesizing colloidal nanoparticles comprising the step of creating a reactive three-phase foam containing reactants therein for synthesizing the colloidal nanoparticles. | 09-08-2011 |
20110200986 | BIO-ASSAY USING LIQUID CRYSTALS - There is provided a method, an in vitro method and a detection system for detecting the presence of at least one biological molecule in at least one sample. The method can include, for example, providing a sample and/or a binding agent to a contact portion of a surface by way of at least one microfluidic channel; disposing a liquid crystal at the contact portion; determining whether the orientation of the liquid crystal changes after the sample contacts the binding agent, indicating the presence of the biological molecule; and determining length of bright region of the liquid crystal and/or change in interference color of said liquid crystal, and consequently indicating the quantity of said biological molecule. Also disclosed are methods of detecting biological molecules using at least one 4′-pentyl-biphenyl-4-R, where R may be at least one functional group selected from carboxylic acid, amine, aldehyde, and oligopeptide. | 08-18-2011 |
20110192281 | POLYMER BLENDS AND CARBONIZED POLYMER BLENDS - A composition includes a first polymer having monomers each containing an imidazole group, and a second polymer, the first and second polymers being a polymer blend. The first polymer, the second polymer, or both may be cross-linked. The carbonized composition, polymeric and carbon membranes (either in the form of a flat sheet or a hollow fiber) made from the composition are also described. The polymeric and carbon membranes can be used to separate and purify gases or liquids | 08-11-2011 |
20110170330 | Graphene Memory Cell and Fabrication Methods Thereof - The disclosed memory cell ( | 07-14-2011 |
20110136935 | BONE AND/OR DENTAL CEMENT COMPOSITION AND USES THEREOF - The present invention provides a composition comprising: at least one viscosity-enhancing agent; and at least one macromonomer. In particular, the composition may be a bone cement composition and/or a dental cement composition. The composition may be used in medicine. The composition may be used in orthopedic and/or periodontal applications. The present invention also provides uses of the composition. | 06-09-2011 |
20110136021 | CATHODE DESIGN - A cathode for a fuel cell comprising a catalyst layer; a backing layer mounted to an aperture in a fuel chamber of said fuel cell; 1) wherein said catalyst layer is mounted to the backing layer on a face opposed to the aperture, so as to be in fluid communication with atmospheric oxygen in the case of microbial fuel cell; and 2) wherein said catalyst layer is mounted to the backing layer on a face opposed to the aperture, so as to be in fluid communication with water in the case of microbial electrolysis cell. | 06-09-2011 |
20110127445 | UPCONVERSION FLUORESCENT NANO-STRUCTURED MATERIAL AND USES THEREOF - Upconversion fluorescent nano-structured material(s) comprising at least one compound of formula (M | 06-02-2011 |
20110107192 | Authoring Tool and Method for Creating an Electrical Document - An authoring tool for creating an electronic document, a method for creating the electronic document, a data storage medium for instructing a computer to execute the method for creating the electronic document and a data storage medium for instructing a computer to display the electronic document. The authoring tool comprises; a template module for selecting a template for the electronic document, the template comprising one or more display pages; a content management module for arranging one or more media files on each display page with selected interrelationships between the media files; a generating module for creating an electronic page file for each display page, wherein the media files are embedded in the respective electronic page files based on the selected interrelationships and in a manner such that each electronic page file includes interrelationship data defining the interrelationships of the embedded media files in said each electronic page file with other media files in said each electronic page file and with other media files in other electronic page files of the electronic document; and a binding module for electronically binding the respective electronic page files so as to create the electronic document. | 05-05-2011 |
20110092518 | Antifouling Compounds And Use Thereof - The present invention relates to the use of compounds which have the following general formula (I), wherein R | 04-21-2011 |
20110027384 | PHOTOSENSITISING COMPOSITION AND ITS USES - The present invention provides a photosensitising composition comprising a mixture of at least one oxygen carrier, at least one oxidising agent and at least one surfactant, and its uses. The ratio of the at least one oxygen carrier to the at least one oxidising agent to the at least one surfactant may be in the range of 50:40:10 to 80:19.8:0.2. The photosensitising composition may be used for treating and/or preventing conditions caused by microorganisms. | 02-03-2011 |
20110026789 | RETINAL IMAGE ANALYSIS SYSTEMS AND METHODS - A platform is proposed for automated analysis of retinal images, for obtaining from them information characterizing retinal blood vessels which may be useful in forming a diagnosis of a medical condition. A first aspect of the invention proposes that a plurality of characteristics of the retina are extracted, in order to provide data which is useful for enabling an evaluation of cardiovascular risk prediction, or even diagnosis of a cardiovascular condition. A second aspect uses fractal analysis of retinal images to provide vascular disease risk prediction, such as, but not limited to, diabetes and hypertension. | 02-03-2011 |
20110023187 | Putative Cytokinin Receptor and Methods for Use Thereof - A method of modulating the expression of at least one trait in a plant, the method comprising the step of modulating the expression of at least one polypeptide by the plant, wherein the polypeptide is selected from the group consisting of: i) a polypeptide which comprises the amino acid sequence according to SEQ ID NO:1; ii) a polypeptide which comprises an amino acid sequence which is selected from the group consisting of any one or more of from amino acid 1 to amino acid 7, from amino acid 9 to amino acid 230, from amino acid 1 to amino acid 58, from amino acid 77 to amino acid 485, from amino acid 59 to amino acid 76, from amino acid 150 to amino acid 191, from amino acid 231 to amino acid 405, and from amino acid 406 to amino acid 438 of SEQ ID NO: 1, or at equivalent positions in a homologue thereof, and which is capable of modulating cytokinin signaling in the plant; iii) a polypeptide which comprises an amino acid sequence with at least 70% sequence identity to the amino acid sequence according to SEQ ID NO:1 and which is capable of modulating cytokinin signaling in the plant; and iv) a polypeptide which consists of an amino acid sequence according to SEQ ID NO:1, wherein the modulation of the expression of the polypeptide modulates the expression of at least one trait in the plant. | 01-27-2011 |
20110021451 | LIPID TUMOUR PROFILE - We describe a method of generating a classification model capable of distinguishing between two biological states, the method comprising the steps of: (a) providing a training dataset, X, comprising concentrations of a plurality of lipids in a biological sample in a first state and a biological sample in a second state; (b) subjecting the training dataset X to Principal Components Analysis (PCA), in which the PCA analysis generates a transformation matrix, C, and a transformed dataset, Y | 01-27-2011 |
20100329974 | HYDROGEN STORAGE MATERIAL AND A PROCESS FOR RELEASE OF HYDROGEN - There is disclosed a hydrogen storage material which may comprise an optionally substituted M-amino-borane complex or a composite comprising: (i) at least one of a M-nitrogen compound; and (ii) a compound comprising (Y—Z)—R bonds. M is a metal or metalloid; Y is an element selected from Group 13 of the Periodic Table of Elements; Z is an element selected from Group 15 of the Periodic Table of Elements; and R is hydrogen (H) or a hydrocarbyl. | 12-30-2010 |
20100297616 | SITU HYBRIDISATION METHOD - There is provided an improved method of in situ hybridisation. In particular, a method of in situ hybridisation of biopolymer(s) in a sample of cells, with the proviso that the digestion of polypeptides is not performed. The method may be applicable to detection of different types of biopolymers, including detection of nucleic acids and polypeptides in the same sample. In particular, the method is for the detection of chromosomal abnormalities in uncultured amniotic cells. | 11-25-2010 |
20100290703 | Enhancing Photograph Visual Quality Using Texture and Contrast Data From Near Infra-red Images - Near infra-red images of natural scenes usually have better contrast and contain rich texture details that may not be perceived in visible light photographs. The contrast and rich texture details form a NIR image corresponding to a visible light image are useful for enhancing the visual quality of the visible light image. To enhance the visual quality of a visible light image using its corresponding near infra-red image, a computer-implemented method computes a weight region mask from the visible light image, transfers contrast data and texture data from the near infra-red image to the visible light image guided by the weighted region mask. The contrast data is computed from the low frequency subbands of the visible light image and corresponding infra-red image after a wavelet transform by matching the histogram of gradient magnitude. The texture data is computed from the high frequency subbands of both images after wavelet transform. | 11-18-2010 |
20100273743 | MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT - The invention is directed to a method of administering hydrogen sulfide (H | 10-28-2010 |
20100258426 | APPARATUS AND METHOD FOR DESALINATION - A water desalination system includes an evaporator for evaporating saline water to produce water vapor and an adsorption means in selective vapor communication with the evaporator for reversibly adsorbing the water vapor from the evaporator. The adsorption means is in selective vapor communication with a condenser, and desorbing means for desorbing the adsorbed water vapor from the adsorption means for collection by the condenser. The condenser is adapted to condense the water vapor to desalinated water. | 10-14-2010 |
20100206811 | POLYMERIC MEMBRANES INCORPORATING NANOTUBES - The present invention relates to semipermeable membranes with nanotubes dispersed therein, and the methods of preparing the same. | 08-19-2010 |
20100158916 | DIAGNOSTIC BIOMOLECULE(S) - The present invention relates to methods for the identification and/or quantification of biomolecule(s). There is also provided a novel method of identifying and/or quantitating biomolecule(s) in a proliferative cell disorder by providing at least one cyst fluid sample and determining the expression of haptoglobin protein, derivative, mutant and/or fragment thereof. | 06-24-2010 |
20100121603 | METHOD AND SYSTEM FOR FALL-ONSET DETECTION - A method and system for fall-onset detection is provided. The method includes the steps of monitoring acceleration at the thigh of a person; monitoring acceleration at the waist of the person; monitoring orientation of the thigh of the person; and detecting the fall-onset if the orientation of the thigh exceeds a first threshold value and a correlation between variation in acceleration of the thigh and variation in acceleration of the waist exceeds a second threshold value and a correlation between variation in the orientation of the thigh and a fall-template variation exceeds a third threshold value. | 05-13-2010 |
20100113857 | FIBERS FOR DECONTAMINATION OF CHEMICAL AND BIOLOGICAL AGENTS - A nano-sized or micro-sized fiber comprising particles capable of at least partially detoxifying a toxic agent. | 05-06-2010 |
20100112563 | MULTIPLEX ANALYSIS OF NUCLEIC ACIDS - A method for identifying target nucleic acids includes the steps of contacting a sample containing a plurality of target nucleic acids with at least one series of nucleotide primers under conditions that allow binding of said primers to at least one of said target nucleic acids and labeling of said bound primers with a detectable signal, wherein one member within each series has a lower level of specificity than other members of the series; and measuring said detectable signal of each labeled primer to determine the identity of said target nucleic acids. | 05-06-2010 |
20100103247 | AN IMAGING DEVICE AND METHOD - An imaging system comprising an image capture apparatus, arranged to capture a stereoscopic image of an operator work site, in communication with a display system; the display system arranged to receive and display said stereoscopic image on a display screen to said operator; wherein said display system is arranged such that the display screen is placed intermediate the operator's eyes and the work site. | 04-29-2010 |
20100075865 | MICROARRAY SYSTEM AND A PROCESS FOR PRODUCING MICROARRAYS - A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on differences between each image. Also disclosed in a system for using the microarray. | 03-25-2010 |
20100068517 | ENHANCED SILK PROTEIN MATERIAL HAVING IMPROVED MECHANICAL PERFORMANCE AND METHOD OF FORMING THE SAME - The invention provides an enhanced silk fiber rivaling spider silk in mechanical performance, in combination with a very low-cost method for producing it from the usual silkworms. The method provides for the simple application of an electric field which results in an enhancement of over (?) 40% in the strength, and of 200% in the breaking energy with respect to ordinary silkworm silk. The critical elasticity is enhanced to the level of the dragline spider silk. The provided enhanced silk protein material has the same protein primary structure, fiber diameter and length of the customary silk. The method of formation offers the following advantages in comparison to other methods available in the prior art. Industrial scale production can be readily and cost-effectively achieved, given the wide-range availability of silkworms. The provided method relies largely on the present standard production processes of silkworm silk, and hence a low level of investment is required. Since no additional chemicals are required, the provided method is environmentally friendly. | 03-18-2010 |
20100062980 | THERAPEUTIC USES OF BETA-ANTAGONISTS - Polypeptides derived from | 03-11-2010 |
20090321634 | Multi-beam ion/electron spectra-microscope - This invention is a multi-beam charged particle instrument that can simultaneously focus electrons and a variety of positive and negative ions, such as Gallium, Oxygen and Cesium ions, onto the same material target. In addition, the instrument has provision to simultaneously capture the spectrum of both secondary electrons and ions. The highly dispersive, high resolution mass spectrometer portion of the instrument is expected to detect and identify secondary ion species across the entire range of the periodic table, and also record a portion of their emitted energy spectrum. The electron energy spectrometer part of the instrument is designed to acquire the entire range of scattered electrons, from the low energy secondary electrons through to the elastic backscattered electrons. | 12-31-2009 |
20090319503 | MATCHING QUERIES IN A NETWORK - A method of matching queries in a hybrid infrastructure/infrastructure-less network, the network comprising pluralities of first and second type communication devices respectively, the method comprising placing a first query by a user on one of the first type devices and forwarding the query via infrastructure based communication to one of the second type devices; forwarding, depending on a category of the first query, the first query from the one second type device to one or more first type devices via infrastructure based communication; and relaying the first query from each of one or more first type devices to one or more neighbouring first type devices via infrastructure-less communication. | 12-24-2009 |
20090298120 | METHOD FOR EXPRESSING SIALYLATED GLYCOPROTEINS IN MAMMALIAN CELLS AND CELLS THEREOF - Methods and systems for producing glycoproteins having sialylated oligosaccharides are provided. The invention comprises the genetic engineered cells with a CMP-sialic acid transporter (CMP-SAT) gene so that the cells express the CMP-SAT protein or fragment thereof at an above endogenous levels. The increase in CMP-SAT expression allows for the increased transport of the CMP-sialic acid into the Golgi apparatus so as to obtain sialylation of glycoproteins at above endogenous levels. In particular, the methods and systems of the invention are useful for producing complex sialylated glycoproteins in mammalian cells of interest, for example Chinese Hamster Ovary (CHO) cells. | 12-03-2009 |
20090291311 | METHOD OF FORMING A NANOSTRUCTURE - A method of forming a discrete nanostructured element at one or more predetermined locations on a substrate is presented. The method includes forming a mask member over the substrate. A window is formed in the mask member at each of one or more locations at which it is required to form the nanostructured element thereby to expose a portion of a surface of the substrate. A portion of the substrate exposed by the window at the one or more locations is removed to form one or more recesses in the substrate. The method further includes forming a layer of a nanostructure medium over a surface of the recess and annealing the structure thereby to form the nanostructured element in each of the one or more recesses. The nanostructured element includes a portion of the nanostructure medium and has an external dimension along at least two substantially orthogonal directions of less than substantially 100 nm. | 11-26-2009 |
20090286373 | METHOD FOR FABRICATING SEMICONDUCTOR DEVICES WITH SHALLOW DIFFUSION REGIONS - A method for fabricating a semiconductor device is presented. The method includes providing a substrate and forming a gate stack over the substrate. A first laser processing to form vacancy rich regions within the substrate on opposing sides of the gate stack is performed. The vacancy rich regions have a first depth from a surface of the substrate. A first implant causing end of range defect regions to be formed on opposing sides of the gate stack at a second depth from the surface of the substrate is also carried out, wherein the first depth is proximate to the second depth. | 11-19-2009 |
20090286278 | MULTI-LAYER CELL ENCAPSULATION FOR TISSUE ENGINEERING - A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection. | 11-19-2009 |
20090285825 | NOVEL SNAKE TOXIN - This invention is in the field of snake venom and the invention provides a novel snake toxin protein and nucleic acids encoding the same. Also, provided are various uses and compositions based on the discovery of the novel snake toxin. | 11-19-2009 |
20090285766 | Photosensitising Composition and Uses Thereof - The present invention provides a photosensitising composition comprising a mixture of: at least one surfactant; at least one alcohol; and/or water, with the proviso that when the at least one surfactant is an alcohol, it is different from the at least one alcohol. In particular, the composition may comprise a mixture of glycerol, ethanol and water. Alternatively, the composition may comprise a mixture of polyethylene glycol, ethanol and water. The photosensitising composition may further comprise at least one photosensitising compound. The present invention also provides a method of treating and/or preventing conditions caused by microorganisms in a subject. | 11-19-2009 |
20090269144 | Extraction System For Removable Marine Footing - The present invention describes an extraction system ( | 10-29-2009 |
20090217855 | PONTOON-TYPE FLOATING STRUCTURE - A pontoon-type floating structure comprising an upper deck that is to be maintained above water level and that is to receive and support a load by the load resting thereon; and a horizontal array of chambers disposed underneath the upper deck, with the chambers providing a first set of chambers that provide the structure with buoyancy, and a second set of chambers with water having access thereto so that the second set of chambers, under steady state conditions, do not provide buoyancy. | 09-03-2009 |
20090214984 | METHODS FOR ENHANCING PHOTOLITHOGRAPHY PATTERNING - A method for fabricating a a semiconductor device that includes: providing a substrate prepared with a photoresist layer; providing a photomask comprising a first and a second pattern having a respective first and second pitch range; providing a composite aperture comprising a first and a second off-axis illumination aperture pattern, the first off-axis aperture pattern having a configuration that improves the process window of the first pitch range and the second off-axis aperture pattern having a configuration that improves the process window for a second pitch range; exposing the photoresist layer on the substrate with radiation from an exposure source through the composite aperture and the photomask; and developing the photoresist layer to pattern the photoresist layer. | 08-27-2009 |
20090202616 | Composite, Method of Producing the Composite and Uses of the Same - The invention relates to a composite comprising a semi-permeable barrier layer that is permeable to oxygen and impermeable to moisture; and a scaffold fiber layer formed by electrospinning fibers on one side of the barrier layer. | 08-13-2009 |
20090202386 | Alloys, Bulk Metallic Glass, And Methods Of Forming The Same - An alloy having a formula: (Zr1Ti) | 08-13-2009 |
20090189215 | NONVOLATILE FLASH MEMORY DEVICE AND METHOD FOR PRODUCING THE SAME - A method of producing metallic nanocrystals ( | 07-30-2009 |
20090169582 | RECOMBINANT LACTOBACILLUS AND USE OF THE SAME - The invention relates to recombinant | 07-02-2009 |
20090167587 | ANALOG-TO-DIGITAL CONVERTER - An analog-to-digital converter (ADC) and a battery operated electronic device comprising the ADC. The ADC comprising an input switch; an array of binary-weighted capacitors, the array of capacitors receiving the input voltage signal via the input switch in an on state of the input switch; a plurality of switches, each switch connected in series with a respective one of the capacitors at an opposite side compared to the input switch, wherein a VDD signal is applied to each switch in one switching state and ground in another switching state; a comparator having as one input a voltage from the input switch side of the array of capacitors and as another input a voltage of VDD/2; and a switch control unit coupled to an output of the comparator for controlling the switches based on the output from the comparator. | 07-02-2009 |
20090153468 | Virtual Interface System - The invention relates to a virtual interface system, to a method of providing a virtual interface, and to a data storage medium having stored thereon computer code means for instructing a computer system to execute a method of providing a virtual interface. A virtual interface system comprises a camera; a processor coupled to the camera for receiving and processing video data representing a video feed captured by the camera; a display coupled to the processor and the camera for displaying first and second interface elements superimposed with the video feed from the camera in response to display data from the processor, the second interface element being displayed at a fixed location on the display; wherein the processor tracks a motion action of a user based on the video data received from the camera, controls a display location of the first interface element on the display based on the tracked motion action; and determines a user input based on a relative position of the first and second interface elements on the display. | 06-18-2009 |
20090137484 | Neuronal Network-Interacting Peptide - The invention provides a method for treating a neuronal-associated condition comprising administering a composition comprising a therapeutically effective amount of a polypeptide or a biologically active fragment thereof, the polypeptide or the fragment thereof capable of modulating the interaction between Nogo-ephrinB and/or Nogo-Grb4 third SH3 domain. There are also provided isolated polypeptide or fragment thereof. The invention further provides a method of screening a compound for effectiveness as an agonist or as an antagonist of the polypeptide or fragment thereof according to the invention. | 05-28-2009 |
20090130130 | MUTANT ALLERGEN(S) - There is provided an isolated polypeptide, derivative, isoform and/or fragment thereof, wherein the polypeptide is a mutant of a Group 5 allergen. There are also provided pharmaceutical compositions(s) and vaccine(s) for the treatment of subjects allergic to at least one Group 5 allergen. | 05-21-2009 |