MOLOGIC LTD Patent applications |
Patent application number | Title | Published |
20140051095 | ENZYME DETECTION DEVICE - An enzyme detection device ( | 02-20-2014 |
20130053543 | PEPTIDE CLEARING AGENTS - A peptide clearing agent is provided for clearance of a conjugate of an enzyme and a binding molecule which binds specifically at a target location from a non-target location in a subject. The peptide clearing agent binds the active site of the enzyme. The peptide also binds to the asialoglycoprotein receptor expressed by hepatic cells to facilitate clearance through the liver. The peptide may be glycosylated to facilitate clearance through the liver by binding to hepatic cells expressing an asialoglyco-protein receptor. Typically, the peptide prevents or inhibits enzyme activity upon binding to the enzyme and is not substantially modified by the enzyme activity. The peptide may be based upon the dipeptide amino-naphthoic acid (ANA)-glutamate (GIu) and may comprise the amino acid sequence serine (Ser)-Alanine (Ala)-amino-naphthoic acid (ANA)-glutamate (GIu). In such cases, the enzyme of interest is typically CPG2. | 02-28-2013 |
20120149032 | ENZYME DETECTION DEVICE - An enzyme detection device ( | 06-14-2012 |
20110086370 | Protease Detection - A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with a conjugated aldehyde. The polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid. | 04-14-2011 |
20090203059 | PROTEASE DETECTION PRODUCT - A protease detection product ( | 08-13-2009 |
20090191582 | ENZYME DETECTION - An enzyme detection product ( | 07-30-2009 |
20090098020 | Binding Assay - A binding assay product ( | 04-16-2009 |
20090092975 | SELECTABLE MARKER - A nucleic acid sequence encoding a decarboxylation enzyme E.G. PAD1 is used as a selectable marker in a recombinant organism. A weak acid is used as the selecting agent. | 04-09-2009 |
20090053738 | PROTEASE DETECTION - A method of detecting a protease in a sample. The method comprises providing an analyte degradable by the protease. The analyte is contacted with the sample. The degradation products of the analyte or the residual undegraded analyte is detected in a binding assay. | 02-26-2009 |