McGill University Patent applications |
Patent application number | Title | Published |
20150236345 | LAYERED AND SPINEL LITHIUM TITANATES AND PROCESSES FOR PREPARING THE SAME - A process for producing lithium titanate which includes the steps of synthesizing a lithium titanate hydrate intermediate via aqueous chemical processing, and thermally treating the lithium titanate hydrate intermediate to produce the lithium titanate. The lithium titanate hydrate is preferably (Li | 08-20-2015 |
20140213802 | (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome - A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula: | 07-31-2014 |
20140086874 | BIOMATERIAL, METHOD FOR MAKING THE BIOMATERIAL AND USES OF THE SAME - A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated. | 03-27-2014 |
20140057971 | LaFORA'S DISEASE GENE - A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EPM2A have been found that co-segregate with Lafora's disease. | 02-27-2014 |
20140011742 | Bioactive Peptides and Proteins Containing Bioactive Peptides, their Uses and Processes for Making the Same - A process for treating a protein before hydrolytic digestion, the process comprising exposing the protein to at least one cycle of microwave irradiation to produce a microwave treated protein containing one or more bioactive peptides. Further hydrolyzing the microwave treated protein to release at least one of the one or more bioactive peptides. A pharmaceutical composition, supplement and food product including the microwave treated protein or the one or more released bioactive peptides. | 01-09-2014 |
20130203977 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF - The invention relates to oligonucleotides having alternating segments of sugar-modified nucleosides and 2′-deoxynucleosides, and uses thereof. The invention further related to oligonucleotides having alternating segments of sugar-modified nucleotides and 2′-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, and oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as component of compositions and commercial packages corresponding to such methods and uses. | 08-08-2013 |
20130172242 | GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention provides novel peptides that can modulate the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and sub-types, isoforms and variants thereof). These peptides are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperproliferative disorders. | 07-04-2013 |
20130121956 | Composition for Enhancing Bone Formation - Disclosed herein is a matrix for inducing or enhancing osteoclast differentiation. The matrix comprises a material having an osteoclastogenic agent associated therewith, the agent being releasable from the material in an amount which is sufficient to induce or enhance osteoclast differentiation. | 05-16-2013 |
20120312370 | HYBRID DYE-SENSITIZED SOLAR CELL PHOTOANODES BASED ON AQUEOUS SYNTHESIZED TITANIUM DIOXIDE - The invention describes a novel process for the aqueous synthesis of rutile and anatase nanocrystallites, their blending for preparation of a hybrid paste for single-layer (bi-functional) film deposition and the formulation of new water-based TiO | 12-13-2012 |
20120232135 | (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome - A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula: | 09-13-2012 |
20120173154 | OXIDATIVE STRESS MEASUREMENT DEVICE AND RELATED METHODS - For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more oxidative stress component in the form of a redox signature for the patient. Probability data of the presence of an oxidative stress dependent disease can be calculated. By observing at least one additional clinical condition of the disease, a diagnosis using said at least one additional condition and said redox signature can be obtained. | 07-05-2012 |
20120172356 | SERUM BIOMARKERS FOR CHAGAS DISEASE - The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry. | 07-05-2012 |
20120135918 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF - The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A | 05-31-2012 |
20120029067 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use - The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers. | 02-02-2012 |
20110217001 | HIGHLY NONLINEAR OPTICAL WAVEGUIDE STRUCTURE WITH ENHANCED NONLINEARITY AND MECHANICAL ROBUSTNESS - There is described an optical waveguide structure exhibiting nonlinear properties, a method of fabricating such, and an optical coupling device made of two of such optical waveguide structures. The optical waveguide structure comprises an optical waveguide portion made of a light transmitting material for supporting a light mode traveling therein. The light transmitting material has an intrinsic nonlinearity parameter suitable for inducing a nonlinearity on the light mode, and the optical waveguide portion having a diameter sized to securely confine the light mode therein and to increase the nonlinearity on the light mode. The optical waveguide structure also has a coating surrounding the optical waveguide portion to mechanically support or to protect the optical waveguide portion from surface damage. | 09-08-2011 |
20110189663 | ASSESSMENT OF RISK FOR COLORECTAL CANCER - Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP). | 08-04-2011 |
20110178402 | ULTRASONIC MEASUREMENT OF pH IN FLUIDS - The present invention pertains to new methods and apparatuses for the determination of pH of a fluid. Applicants have discovered that ultrasonic spectrophonometry (the study and measurement of acoustic spectra) can be used to distinguish conformational changes of albumin and red blood cells in response to pH. In accordance with the present invention, there is provided a method of determining the pH of a fluid based on a pH-dependent conformation of at least one fluid constituent comprising subjecting the fluid to an ultrasonic pulse; detecting ultrasonic spectral data of the fluid constituent resulting from the ultrasonic pulse; wherein the spectral data varies with pH; and then calculating pH from the spectral data. | 07-21-2011 |
20100283969 | BINOCULAR VISION ASSESSMENT AND/OR THERAPY - This invention is a game platform for the assessment and/or treatment of disorders of binocular vision, such as amblyopia. The game content is devised to maximize the possible therapeutic effects by leveraging advanced research in opthalmology, as well as advanced display technology to render images independently to each eye. In particular, the game content engages both eyes at different levels of difficulty, forcing an amblyopic eye to work harder to regain its performance in the visual system. The invention herein described provides a mobile device, capable of interaction with an eye care specialist, for the assessment/treatment of binocular vision using innovative mechanisms for ensuring proper use thereof. | 11-11-2010 |
20100273274 | POLYNUCLEOTIDES ENCODING ACETYLCHOLINE-GATED CHLORIDE CHANNEL SUBUNITS OF CAENORHABDITIS ELEGANS - The invention relates to novel polynucleotides which encode novel polypeptides that are acetylcholine-gated chloride channel subunits and immunogenic or acetylcholine-binding fragments thereof. The novel polypeptides may be used for identifying compounds that modulate the acetylcholine-gated chloride channels, e.g. for use as pesticides and antiparasitic agents. Methods for identifying compounds that modulate the acetylcholine-gated chloride channels are provided. | 10-28-2010 |
20100267836 | NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES - Novel melatonin ligands of Formula I: | 10-21-2010 |
20100240066 | COMPOUNDS AND METHODS FOR MODULATING CADHERIN-MEDIATED PROCESSES - Peptides comprising a cadherin cell adhesion recognition (CAR) sequence, and compositions comprising such peptides, are provided. Methods of using such peptides for modulating cadherin-mediated processes in a variety of therapeutic contexts are also provided. Methods are also provided for identifying compounds that are capable of modulating cadherin-mediated processes. | 09-23-2010 |
20100201942 | BINOCULAR VISION ASSESSMENT AND/OR THERAPY - An information content difference between a left eye image and a right eye image is adjustable to achieve binocular vision in a patient having a deficiency of binocular vision. A source of image pairs is used along with a dichoptic display system to present a selected one of the images pairs as a right eye image to a patient's right eye and a left eye image to a patient's left eye. The difference at which a patient achieves binocular vision is a measure of a level binocular vision health or function, and continued exposure to the image pairs is therapeutic. The difference can be adjusted during therapy, and restoration of regular binocular vision is possible. | 08-12-2010 |
20100173985 | Polyphenol proteasome inhibitors, synthesis, and methods of use - The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers. | 07-08-2010 |
20100105564 | Stroma Derived Predictor of Breast Cancer - The invention provides methods and compositions for use in the diagnosis and management of cancer, particularly breast cancer. The invention utilizes differential gene expression profiles in tumor associated stroma and normal stroma to compile a stroma derived prognostic predictor that classifies breast cancer patients according to clinical outcome. The application provides nucleic acids, antibodies, microarray chips and kits for use with the methods described in the application. | 04-29-2010 |
20100101670 | ELECTRICAL MICROVALVE AND METHOD OF MANUFACTURING THEREOF - The present invention relates to a microvalve for controlling a fluid flow in a microchannel, to a microfluidic circuit using the microvalve, and to a manufacturing method thereof. The microvalve has a first electrode located on a portion of the microchannel, a second electrode over the microchannel and substantially aligned with the first electrode forming a membrane with substantially no resilience. In function, upon application of an electric force on the first and second electrodes, the second electrode draws nearer the first electrode, thus obstructing the microchannel. The microfluidic circuit comprises multiple microchannels and at least one microvalve affixed to one of the multiple microchannels, wherein the at least one microvalve is adapted to indirectly actuate a flexible valve adapted to regulate a flow of fluid in another one of a multiplicity of microchannels. | 04-29-2010 |
20100047782 | ASSESSMENT OF RISK FOR COLORECTAL CANCER - Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP). | 02-25-2010 |
20100041869 | IONIC LIQUID SUPPORTED SYNTHESIS - The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides. | 02-18-2010 |
20100016435 | HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES - Novel chemical agents are described. More specifically, hybrid molecules comprising a vitamin D receptor agonist moiety and an HDAC inhibitor moiety are described herein. | 01-21-2010 |
20100009346 | Lafora's disease gene - A novel gene (EPMZA) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EMP2A have been found that co-segregate with Lafora's disease. | 01-14-2010 |
20100003672 | CDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF - The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects. | 01-07-2010 |
20090221476 | Peptide Capable of Altering Tubulin Polymerization and use Thereof for Inhibiting Cell Proliferation - The invention concerns a peptide derived from intermediate filaments and an intermediate filament fragment capable of altering tubulin polymerization and used for inhibiting cell proliferation, and more particularly for obtaining medicines designed to prevent or treat diseases involving cell proliferation, such as cancers for example. | 09-03-2009 |
20090197943 | Flavonoid Dimers and Methods of Making and Using Such - Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases. | 08-06-2009 |
20090186839 | Model for studying the role of genes in chemoresistance - The invention provides novel inhibitors of protein translation initiation and inhibitors of eIF4F activity that can increase chemosensitivity or diminish or reverse chemoresistance in growth transformed cells and thereby reduce hyperproliferative conditions, such as cancer progression, in select patient populations having particular tumor genotypes. The invention also provides methods which target translation initiation controls in growth-transformed cells, such as tumor subtypes with altered expression of a gene activity, including the human akt, bcl-2, eIF4E, eIF4A or PTEN activities, to restore drug sensitivity in vivo in a genotype selective manner. In one aspect, the inhibitors of translation initiation of the invention are rocaglates, i.e., cyclopenta[b]benzofurons, which increases chemosensitivity or diminishes or reverses chemoresistance either alone or in combination, additively or synergistically, with other agents that alter growth or death. Preferably, the rocaglate is silvestrol, which is used alone or in combination with doxorubicin to reverses chemoresistance in PTEN-deficient lymphomas or eIF4E-over-expressing lymphomas and to promote cancer remission. | 07-23-2009 |
20090175903 | MEASLES SUBUNIT VACCINE - Compositions and methods for making and using therapeutic formulations of measles virus antigens with a Proteosome-based adjuvant are provided. The measles virus antigens may be derived from a variety of sources, such as from recombinant production or from a split antigen preparation. The measles vaccine formulations may be used, for example, in methods for treating or preventing a measles virus infection and eliciting a protective immune response. | 07-09-2009 |
20090149334 | METHODS AND APPARATUS FOR DETECTING LIQUID INSIDE INDIVIDUAL CHANNELS IN A MULTI-CHANNEL PLATE - There is provided a method of measuring properties of a liquid contained in individual wells inside a multi-well array, the method comprising steps of providing capacitor electrodes in the multi-well array, the electrodes adapted to detect a capacitance value of each one of the individual wells without interference of neighboring wells, measuring a capacitance inside each one of the individual wells, and using the capacitance measurements to calculate at least one property of the liquid contained in each one of the individual wells. There is further provided an apparatus for measuring properties of a liquid contained in individual wells inside a multi-well array, and a method of controlling quality of liquid handling task that is repeated across a set of individual wells inside a multi-well array. | 06-11-2009 |
20090142834 | Multipotent stem cells from peripheral tissues and uses thereof - This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues. | 06-04-2009 |
20090130665 | POLYMER COMPOSITIONS AND USES THEREOF - Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1. | 05-21-2009 |
20090121749 | Generation of an Analog Gaussian Noise Signal Having Predetermined Characteristics - The present invention relates to a method and system for providing an analog Gaussian noise signal having the predetermined probability distribution function, bandwidth and center frequency. A band-limited digital noise signal indicative of a Gaussian noise signal having a predetermined Gaussian probability distribution function is ΣΔ modulated generating a pulse-density modulated 1-bit sequence representing a Gaussian noise signal having a predetermined probability distribution function, bandwidth and center frequency. Using an analog low-pass filter the pulse-density modulated 1-bit sequence is then converted into a respective analog Gaussian noise signal having the predetermined probability distribution function, bandwidth and center frequency. The method and system are successfully employed in numerous applications such as in histogram testing and probabilistic digitization. | 05-14-2009 |
20090105467 | Antisense oligonucleotide constructs based on beta-arabinofuranose and its analogues - The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention relates to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues. More particularly this invention relates to the use of antisense oligonucleotides having arabinose sugars to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc. | 04-23-2009 |
20090103568 | Method and System for Non-Gaussian Code-Division-Multiple-Access Signal Transmission and Reception - The present invention relates to a method and system for non-Gaussian code-division-multiple-access signal transmission and reception. Input probability data indicative of a non-equiprobable channel input probability mass function are determined based on received channel data indicative of characteristics of a CDMA transmission channel. The input probability data are determined such that a transmission signal received after transmission has a non-Gaussian distribution. Upon receipt of input user data, a CDMA signal is generated by modulating the received user input data in dependence upon the input probability data and provided for transmission. After transmission a received transmission signal is first processed for determining second channel data and then for determining an estimate indicative of the user input data based on the second channel data. | 04-23-2009 |
20090053802 | Multipotent stem cells from peripheral tissues and uses thereof - This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues. | 02-26-2009 |
20080312549 | Method and Apparatus for Determining Spasticity - There is provided a system and a method for quantitative measurement of spasticity in a patient. It has been found that stretch reflex measurements, that are quantitatively indicative of spasticity, can be obtained by recording an EMG signal while the limb is being moved at a variety of angular velocities. The method advantageously allows the clinician to perform the test at the bedside by eliminating the need for cumbersome mechanical components for moving the limb while providing quantitative measurements. | 12-18-2008 |
20080298540 | DEFORMABLE PHANTOM APPARATUS - A deformable phantom apparatus for simulating motion of a patient's anatomy in 3D during breathing, the apparatus comprising a chamber fillable with a first fluid, a deformable member comprising tissue equivalent material of the anatomy being simulated, the deformable member being positionable within the chamber in the first fluid and having an open end in fluid communication with a second fluid outside the chamber in use; and a mechanism for causing the second fluid to flow through the open end to deform the deformable member between a normal state and a deformed state to simulate motion during breathing. | 12-04-2008 |