Brigham Young University Patent applications |
Patent application number | Title | Published |
20160097748 | AUTONOMOUS AMBIENT AIR SAMPLING SYSTEM FOR MONITORING SEMI-VOLATILE/NON-VOLATILE ORGANIC COMPOUNDS - An automated ambient air sampling system and method for monitoring organic compounds that may provide continuous data, the system including a thermal desorption system, an injection port, a pre-concentration system, a gas chromatograph and an ion trap mass spectrometer, wherein an air sampling chamber may also function as a thermal desorption chamber. | 04-07-2016 |
20160096864 | CATIONIC STEROIDAL ANTIMICROBIAL PRODRUG COMPOSITIONS AND USES THEREOF - Prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, or polymorphs thereof include a pharmaceutically and/or diagnostically active cationic steroidal antimicrobial (hereinafter “CSA”) compound or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof, and one or more cleavable groups (C.G.). Some embodiments include a CSA compound prepared in an inactive or less active form and that is capable of conversion to a fully active form upon administration to a subject, upon preparation of a pharmaceutical formulation containing the CSA composition, and/or upon exposure to physiological conditions. Pharmaceutical compositions include the prodrug or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof and one or more pharmaceutically acceptable excipients. Methods of treatment of bacterial infections in a patient in need utilize prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs thereof and/or the pharmaceutical compositions described herein. | 04-07-2016 |
20160052959 | RADIOLABELED CATIONIC STEROID ANTIMICROBIALS AND DIAGNOSTIC METHODS - The disclosure provides compounds, methods, and kits for diagnosis, detection, screening, and imaging of a disease condition (e.g., infection, cancer, tumor, neoplasia), in vitro, ex vivo, and/or in vivo. Certain embodiments include administering a cationic steroid antimicrobial “CSA” or “ceragenin”), the CSA including a steroidal backbone and a heterocyclic ring separated from the steroidal backbone by at least 4 atoms (and up to 24 atoms or more), to a subject having or at risk of having a disease condition in an amount effective to diagnose, detect, screen for or image the disease condition in the subject. | 02-25-2016 |
20160045421 | ORAL CARE COMPOSITIONS AND METHODS OF USE - Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same. | 02-18-2016 |
20150374720 | METHODS AND PRODUCTS FOR INCREASING THE RATE OF HEALING OF TISSUE WOUNDS - Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of a tissue wound. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 12-31-2015 |
20150374719 | METHODS FOR TREATING FUNGAL INFECTIONS - Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 12-31-2015 |
20150366880 | COMPOSITIONS AND METHODS FOR TREATING BONE DISEASES AND BROKEN BONES - Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 12-24-2015 |
20150330955 | LOW-POWER MINIATURE LED-BASED UV ABSORPTION DETECTOR WITH LOW DETECTION LIMITS FOR CAPILLARY LIQUID CHROMATOGRAPHY - A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits. | 11-19-2015 |
20150314342 | METHODS AND APPARATUS FOR CLEANING OR DISINFECTING A WATER DELIVERY SYSTEM - Methods for cleaning or disinfecting water delivery systems, self-cleaning or self-disinfecting water delivery systems, and inserts for use in cleaning or disinfecting water delivery systems utilize cationic steroidal antimicrobial (CSA) molecules to kill microbes and/or break up biofilms within water delivery systems. The methods and systems involve adding CSA molecules to water to form an aqueous CSA composition and passing the aqueous CSA composition through the water delivery system, such as a water storage vessel and/or water delivery line to clean or disinfect the water delivery system. CSA molecules can be added to a water storage vessel, water delivery line, or well, such as by a solid or liquid CSA composition. A CSA-eluting composition may provide CSA molecules to water to form an aqueous CSA composition that passes through or is stored within the water delivery system. CSA molecules provided to agricultural animals in drinking water may improve animal health. | 11-05-2015 |
20150258123 | ANTI-INFECTIVE AND OSTEOGENIC COMPOSITIONS AND METHODS OF USE - Cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making and using the same. Particularly advantageous uses include treating infections in patient and sub-patient populations, especially those having a bone disease, a broken bone, a bone infection, or a bone implant. | 09-17-2015 |
20150258122 | LAVAGE AND/OR INFUSION USING CSA COMPOUNDS FOR INCREASING FERTILITY IN A MAMMAL - Increasing fertility in a mammal utilizes cationic steroidal antimicrobial (CSA) compounds and CSA-containing compositions. Such treatment in a mammal includes administering a formulation (e.g., lavage and/or infusion) including at least one CSA compound, or pharmaceutically acceptable salt thereof, to the reproductive structure(s) of the mammal (e.g., horse, dairy cow, human, etc.). The formulation may be applied topically as lavage and/or infusion to desired reproductive structures, such as the vagina, cervix, uterus, penis, or combinations thereof. The formulation may kill both planktonic and biofilm forms of sperm killing microbes, and may at least partially break up a microbial plaque or film located within any of the reproductive structures (e.g., the uterus). The CSA or pharmaceutically acceptable salt thereof may be selective or preferential in its action, so as to preferentially kill sperm killing microbes without causing harm to beneficial microbes also residing within the reproductive structure of the mammal. | 09-17-2015 |
20150258121 | COMPOSITIONS AND METHODS FOR FORMING STABILIZED COMPOSITIONS WITH REDUCED CSA AGGLOMERATION - Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 μm in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections. | 09-17-2015 |
20150239928 | CATIONIC STEROIDAL ANTIMICROBIAL COMPOUNDS - Disclosed herein are cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSAs. CSAs may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering CSAs. | 08-27-2015 |
20150203527 | CATIONIC STEROIDAL ANTIMICROBIALS - Disclosed herein are cationic steroidal antimicrobials (“CSA compounds” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSA compounds. CSA compounds may be formulated for treating subjects with ailments responsive to CSA compounds, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering CSA compounds. | 07-23-2015 |
20150140063 | HYDROPHOBIC CERAGENIN COMPOUNDS AND DEVICES INCORPORATING SAME - A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10. | 05-21-2015 |
20150110767 | METHODS FOR TREATING LUNG INFECTIONS AND INFLAMMATION - Methods of treating, reducing, or preventing lung infections or lung inflammation include identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described. | 04-23-2015 |
20150093423 | CERAGENIN PARTICULATE MATERIALS AND METHODS FOR MAKING SAME - Particulate ceragenin materials may be manufactured by (i) providing a ceragenin feed material comprised of ceragenin molecules, each having a sterol backbone and a plurality cationic groups attached thereto; (ii) fracturing the ceragenin feed material in a milling apparatus to produce a ceragenin particulate material having a particle size distribution with a median particle size in a range from 5 nm to 20 μm; and (iii) during fracturing, maintaining the ceragenin feed with a moisture content of less than or equal to 10% by weight. | 04-02-2015 |
20150039636 | SYSTEMS AND METHODS FOR INTELLIGENTLY LINKING AND FORMATTING GENEALOGICAL STRUCTURES - Modeling genealogical trees that span multiple pages can include the creation and use of navigable links between related nodes. When it is determined that a display layout of a genealogical tree will span a plurality of viewable pages by a document viewer, a descendent node is identified that genealogical links directly to a related ancestor node on another page. A selectable ancestor page link is then created and displayed proximate the descendent relative node which, when selected, causes the viewer to render the page containing the ancestor relative node. A selectable descendent page link is also created and displayed proximate the ancestor relative node which, when selected, causes the viewer to render the particular page containing the descendent relative node. Intelligent formatting can also be used to identify and remove or refrain from displaying duplicate branches of the genealogical tree. | 02-05-2015 |
20140369941 | Oral Care Compositions - Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same. | 12-18-2014 |
20140363780 | ORAL CARE COMPOSITIONS - Described herein are aqueous and substantially non-aqueous oral compositions comprising a cationic steroidal compound and methods of making and using the same. | 12-11-2014 |
20140362888 | APPARATUS AND METHOD FOR DETERMINING DENATURATION THERMOGRAMS OF BLOOD PLASMA OR SERUM - An apparatus for determining thermograms of blood plasma or serum includes two or more reaction vessels that each comprise a temperature sensing coil and a heating coil that is coaxial with and exterior to, or interleaved with, the temperature sensing coil. The apparatus also includes a heat conductive body having two or more cavities formed therein for receiving the reaction vessels. A corresponding method includes activating the heating coils of the reaction vessels and collecting temperature data for the reaction vessels with the temperature sensing coils. | 12-11-2014 |
20140336131 | METHODS FOR TREATING INFLAMMATION, AUTOIMMUNE DISORDERS AND PAIN - Disclosed herein are methods of treating, reducing, or preventing a disease such as oral mucositis, gastric mucositis, or inflammatory fibrosis, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 11-13-2014 |
20140329208 | COMPUTER-IMPLEMENTED COMMUNICATION ASSISTANT FOR THE HEARING-IMPAIRED - Computing systems are provided for facilitating communication to the hearing-impaired. The computing systems obtain and modify a video that includes a signer performing sign language about a topic. The video is then modified and presented to a viewer in such a way that the viewer can simultaneously view the sign language and the one or more objects corresponding to the topic. In some instances, the modified video is blended with another video corresponding to the same topic so as to enable a user to view the sign language at the same time as the corresponding video presentation. This can be done in real-time or with a time delay. In other instances, the modified video is rendered on a display through which the user is also viewing the one or more related items associated with the sign language. | 11-06-2014 |
20140324212 | METHOD AND APPARATUS FOR CONCURRENT MULTI-USER TOOLPATH CREATION - A method for generating a toolpath includes providing a plurality of machining target models based on a model of an engineering object, assigning the machining target models to CAM clients operated by users, receiving a machining instruction sequence from each CAM client, and machining a part by executing each of the machining instruction sequences on one or more machine tools. The machining instruction sequences may be merged into a single machining instruction sequence before being executed by a machine tool. The machining target models may be created manually or automatically generated. In certain embodiments, the machining target models are generated by spatially partitioning the model of the engineering object. In one embodiment, features that are allocated to a separate machining process are removed from the machining target models. A corresponding apparatus is also disclosed herein. | 10-30-2014 |
20140318964 | Two-Chamber Dual-Pore Device - Provided is a device comprising a channel through and defined by a plurality of layers surrounding the channel, the channel connecting a first and a second chambers separated by the plurality of layers, wherein the plurality of layers comprise a first layer, a second layer; and a conductive middle layer disposed between the first and second layers, wherein the channel comprises (a) a first region defined by the first layer, denoted as an inlet, that is about 0.5 nm to about 100 nm in diameter and (b) a second region defined by the second layer, denoted as an outlet, wherein the inlet and the outlet are about 10 nm to about 1000 nm apart from each other, and wherein the first and second chambers and the middle layer are connected to a power supply. Also provided are methods of preparing and using the device, in particular for nucleic acid sequencing. | 10-30-2014 |
20140317589 | SYSTEM AND METHOD FOR CONCURRENT MULTI-USER CAX WORKFLOW - A system for concurrent CAx workflow includes a collaborative server that manages a model of an engineering object, the model comprising at least design data and analysis data corresponding to the design data, a design client for editing of the design data by a design user, an analysis client for editing of the analysis data by an analysis user concurrent with editing of the design data by the design user; and wherein the collaborative server and the analysis client are collectively configured (i.e., one or both are configured) to enable the analysis user to edit the analysis data, view a plurality of geometric elements within the design data, and create a reference within the analysis data to a selected geometric element of the plurality of geometric elements within the design data. A corresponding apparatus, method, and computer-readable medium are also disclosed herein. | 10-23-2014 |
20140317531 | SYSTEM, METHOD, AND APPARATUS FOR COLLABORATIVE CAX EDITING - A method for collaborative CAx editing may include storing a model of an engineering object comprising a plurality of features and encoded in a vendor-neutral format within a collaborative data store, detecting updates to the model of the engineering object stored on a first CAx client and encoded in a first proprietary format, converting the updates to feature changes, and updating the model of the engineering object encoded in the vendor-neutral format with the feature changes. The method may also include detecting feature changes for the model of the engineering object encoded in the vendor-neutral format, converting the feature changes to updates for the model of the engineering object encoded in a second proprietary format, and executing the updates for the model of the engineering object encoded in the second proprietary format. A corresponding apparatus, system, and computer-readable medium are also disclosed herein. | 10-23-2014 |
20140315873 | ANIMAL FEED INCLUDING CATIONIC CHOLESTEROL ADDITIVE AND RELATED METHODS - Methods and feed compositions for increasing health of agricultural animals include administering a cationic cholesterol additive through the diet of the animal, such as through solid feed or drinking water of the animals. The method includes feeding an animal a diet comprised of a cationic cholesterol additive, such as a compound with a sterol backbone and a plurality of cationic groups attached thereto. The feed composition may include a solid or liquid feed component and a cationic cholesterol additive. The methods and compositions are useful for animals raised in confined feed operations, such as cattle, swine, horses, sheep, or poultry, and can reduce harmful bacteria in the digestive tract, increase beneficial bacteria flora, improve feed conversion efficiency, reduce morbity and/or mortality, and/or yield harvested meat having reduced content of harmful bacteria. | 10-23-2014 |
20140314998 | POROUS MATERIAL FOR THERMAL AND/OR ELECTRICAL ISOLATION AND METHODS OF MANUFACTURE - In a general aspect, an apparatus can include a substrate and a porous layer disposed on the substrate, the porous layer including a plurality of silica nanotubes. The silica nanotubes of the porous layer can be solid, partially hollow and/or hollow elongate silica structures. | 10-23-2014 |
20140313510 | MULTIPLEX FLUORESCENT PARTICLE DETECTION USING SPATIALLY DISTRIBUTED EXCITATION - A chip-scale optical approach to performing multi-target detection is based on molecular biosensing using fiber-optic based fluorescence or light scattering detection in liquid-core waveguides. Multiplexing methods are capable of registering individual nucleic acids and other optically responsive particles, and are ideal for amplification-free detection in combination with the single molecule sensitivity of optofluidic chips. This approach overcomes a critical barrier to introducing a new integrated technology for amplification-free molecular diagnostic detection. Specific examples of liquid-core optical waveguides and multi-mode interferometers are described; however, they can be implemented in a number of different ways as long as a series of excitation spots is created whose spacing varies with the excitation wavelength. | 10-23-2014 |
20140308754 | FLOW-VALVE DIAGNOSTIC MICROFLUIDIC SYSTEM - A system for detecting concentration of a target in a solution where sample fluid is passed into a microchannel with wall coated with the receptor that reacts and crosslinks with the target to constrict the channel and slow or stop sample flow through the microchannel. Concentration of the target is determined by measuring length of the sample filled channel. | 10-16-2014 |
20140303916 | FOUR-LINE ELECTRICAL IMPEDANCE PROBE - A probe is configured for measuring an electrical impedance of a workpiece using external testing equipment. The probe includes a non-conducting base and an array of at least four spaced-apart line conductors. The at least four spaced-apart line conductors are disposed generally in parallel to each other along their lengths on a surface of the non-conducting base and are electrically connected to a corresponding array of at least four terminals on the non-conducting base. The non-conducting base is configured to be placed over a surface of the workpiece so that the at least four spaced-apart line conductors contact the surface of the workpiece and the at least four terminals are configured to be connected the external testing equipment. | 10-09-2014 |
20140278269 | SCALABLE MULTI-USER CAD SYSTEM AND APPARATUS - A system for scalable multi-user CAD may include a traffic consolidation server consolidating feature edits from CAD workstations editing one or more proximate regions of an engineering object. The traffic consolidation servers may transmit feature changes to other workstations editing the proximate regions of the engineering object while forwarding the feature changes to a CAD model server. CAD model servers may be configured to receive consolidated feature changes pertaining to an assigned region of the engineering object. An assignment server may balance processing loads on traffic consolidation servers. Methods and apparatus corresponding to the above system are also disclosed herein. | 09-18-2014 |
20140274913 | METHODS FOR TREATING INFLAMMATION, AUTOIMMUNE DISORDERS AND PAIN - Compositions and methods for treating, reducing, or preventing a disease or symptom such as gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, or pain. The method includes identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 09-18-2014 |
20140271761 | INCORPORATION OF PARTICULATE CERAGENINS IN POLYMERS - A method and kit for manufacturing a composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 μm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time. | 09-18-2014 |
20140267026 | HANDHELD DOCUMENT READING DEVICE WITH AUXILIARY DISPLAY - A method to display an electronic document includes receiving an electronic document, displaying a current page of the electronic document on a screen of a handheld device operated by a user, and displaying one or more adjacent pages of the electronic document on an external display. The method may also include changing the current page on the screen of the handheld device and the adjacent pages on the external display in response to user input. In some embodiments, the method includes pinning or unpinning one or more selected page(s) on the external display in response to user input. A corresponding apparatus, system, and computer readable medium are also disclosed herein. | 09-18-2014 |
20140260653 | COMPOSITE MATERIAL USED AS A STRAIN GAUGE - In one general aspect, an apparatus comprises a material including a non-layered mixture of an elastomeric polymer with a plurality of voids; and a plurality of conductive fillers disposed in the elastomeric polymer. The apparatus may produce an electrical response to deformation and, thus, function as a strain gauge. The conductive fillers may include conductive nanoparticles and/or conductive stabilizers. In another general aspect, a method of measuring compression strain includes detecting, along a first axis, an electrical response generated in response to an impact to a uniform composite material that includes conductive fillers and voids disposed throughout an elastomeric polymer, and determining a deformation of the impact based on the electrical response. The impact may be along a second axis different from the first axis. | 09-18-2014 |
20140260527 | METHOD AND SYSTEM FOR STRUCTURAL INTEGRITY ASSESSMENT - The method includes dispensing an object at a portion of concrete, determining an impact time of the object on the portion of concrete, detecting at least one acoustic wave reflected from the portion of concrete, filtering the at least one acoustic wave, and identifying a defect in the portion of concrete based on the filtering. | 09-18-2014 |
20140256543 | METHOD OF MAKING HIGHLY POROUS, STABLE ALUMINUM OXIDES DOPED WITH SILICON - The present invention relates to a method for making high surface area and large pore volume thermally stable silica-doped alumina (aluminum oxide) catalyst support and ceramic materials. The ability of the silica-alumina to withstand high temperatures in presence or absence of water and prevent sintering allows it to maintain good activity over a long period of time in catalytic reactions. The method of preparing such materials includes adding organic silicon reagents to an organic aluminum salt such as an alkoxide in a controlled quantity as a doping agent in a solid state, solvent deficient reaction followed by calcination. Alternatively, the organic silicon compound may be added after calcination of the alumina, followed by another calcination step. This method is inexpensive and simple. The alumina catalyst support material prepared by the subject method maintains high pore volumes, pore diameters and surface areas at very high temperatures and in the presence of steam. | 09-11-2014 |
20140236550 | SYSTEM AND METHODS FOR MULTI-USER CAX EDITING DATA CONSISTENCY - A multi-user CAx editing system may comprise a plurality of editing clients. The editing clients may be configured to maintain data consistency for geometric elements created within each local instance of a model of an engineering object. For example, each of the plurality of editing clients may include a synchronization module configured to identify one or more distinguishing parameters for each locally created geometric element and generate a unique persistent label for the geometric element, and communicate the unique persistent label and the distinguishing parameters to other editing clients. The communication may occur via a collaborative editing server. The other editing clients may find a geometric element within their local instance of the model that matches the distinguishing parameters and associate the unique persistent label with that geometric element. Subsequent references to the geometric element may be made by referring to the unique persistent label. | 08-21-2014 |
20140222919 | SYSTEM AND METHODS FOR MULTI-USER CAX EDITING CONFLICT MANAGEMENT - A multi-user CAx editing system may comprise a plurality of editing clients and a collaborative editing server. The server and editing clients may be collectively configured to: a) assign a feature to a first user, detect an attempt to edit the feature by a second user, and reassign the feature to the second user if the first user indicates that the feature may be reassigned, and/or b) detect an editing conflict between a first and second user for a feature and send a reversion request for the feature to one or more clients and/or c) initiate changes for a feature within a remote instance of the electronic model edited by another user and initiate reversion of the changes for the feature within a local instance of the electronic model in response to determining that the changes to the feature within the remote instance of the electronic model generated an error. | 08-07-2014 |
20140222387 | PARALLEL WORKFLOW FINITE ELEMENT PRE-PROCESSING METHOD - A method for collaborative analysis pre-processing of electronic models of engineering objects includes assigning a first user to de-feature a model of an engineering object during a first session to provide a de-featured model of an engineering object, assigning a second user to conduct other FEA pre-processing operations on the model of the engineering object during a second session, and applying the other FEA pre-processing operations for the model of the engineering object to the de-featured model of the engineering object. Example of other FEA pre-processing operations include applying a material definition to a geometry, pre-meshing a geometry, initiating automated meshing of a geometry, validating automated meshing of a geometry, editing a mesh for a geometry, manually meshing a geometry, and defining one or more boundary conditions for a geometry. The second session and the first session may be conducted concurrently. A corresponding system and apparatus are also disclosed herein. | 08-07-2014 |
20140222386 | PARALLEL WORKFLOW FINITE ELEMENT PRE-PROCESSING APPARATUS AND SYSTEM - A method for collaborative analysis pre-processing of electronic models of engineering objects includes assigning a first user to de-feature a model of an engineering object during a first session to provide a de-featured model of an engineering object, assigning a second user to conduct other FEA pre-processing operations on the model of the engineering object during a second session, and applying the other FEA pre-processing operations for the model of the engineering object to the de-featured model of the engineering object. Example of other FEA pre-processing operations include applying a material definition to a geometry, pre-meshing a geometry, initiating automated meshing of a geometry, validating automated meshing of a geometry, editing a mesh for a geometry, manually meshing a geometry, and defining one or more boundary conditions for a geometry. The second session and the first session may be conducted concurrently. A corresponding system and apparatus are also disclosed herein. | 08-07-2014 |
20140207274 | EFFORT MODULATION FOR PROCESS CONTROL OF FRICTION STIR OPERATIONS - A system and method for making adjustments to output effort from a spindle driver using a multi-stage nested control loop of an active controller to provide constant power to a friction stir zone during a friction stir operation. Providing constant power facilitates temperature control within the friction stir zone and thereby improves the result of the operation such as a weld. | 07-24-2014 |
20140199765 | LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A CELL - Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell. | 07-17-2014 |
20140194401 | METHODS FOR REDUCING CELLULAR PROLIFERATION AND TREATING CERTAIN DISEASES - Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 07-10-2014 |
20140188437 | MULTI-USER FINITE ANALYSIS SYSTEMS APPARATUSES AND METHODS - A method for collaborative finite analysis may include obtaining an electronic model of an engineering object, assigning users one or more geometries for pre-analysis editing to provide assigned geometries for each user, and enabling each user to conduct pre-analysis editing of their assigned geometries concurrent with other users. The method may also include conducting finite analysis on the assigned geometries of a first user concurrent with conducting finite analysis on the assigned geometries of a second user. Examples of pre-analysis editing include removing features that are secondary to analysis, applying a material definition to a geometry, pre-meshing a geometry, initiating automated meshing of a geometry, validating automated meshing of a geometry, editing a mesh for a geometry, manually meshing a geometry, defining one or more loads associated with a geometry, and defining one or more boundary conditions for a geometry. A corresponding system and apparatus are also disclosed herein. | 07-03-2014 |
20140170311 | THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS OF MANUFACTURE INCLUDING PRIMING PRIOR TO INFILTRATION WITH STATIONARY PHASE AND/OR PRECURSOR THEREOF - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the TLC plate. Embodiments for TLC plates and related methods are also disclosed. | 06-19-2014 |
20140149882 | SYSTEM, METHOD, AND APPARATUS FOR COLLABORATIVE CAX EDITING - A method for collaborative CAx editing may include (1) enabling editing of a proprietary representation of an engineering object by a user, where the proprietary representation includes one or more features of the engineering object, (2) storing an operations log of the engineering object on a collaborative CAx server, (3) detecting creation of a feature of the engineering object within the proprietary CAx application, and (4) inserting a feature identifier corresponding to the feature within the proprietary representation of the engineering object. A system, apparatus, and computer-readable medium corresponding to the above method are also disclosed herein. | 05-29-2014 |
20140140487 | AMORPHOUS CARBON AND ALUMINUM X-RAY WINDOW - An x-ray window including at least one aluminum layer and at least one amorphous carbon layer. At least one polymer layer may also be included. Aluminum layer(s) can provide improved gas impermeability to the window. Amorphous carbon layer(s) can provide corrosion resistance. Polymer layer(s) can provide improved structural strength. | 05-22-2014 |
20140135387 | USE OF EQUOL OF TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 05-15-2014 |
20140133767 | SCANNED TEXT WORD RECOGNITION METHOD AND APPARATUS - A method for converting digital images to words includes receiving a digital image comprising text, generating a binary image from the digital image for each of N binarization threshold values to provide N binary images, converting each of the N binary images to text, and aligning the text from the N binary images to provide a word lattice for the digital image. Aligning the text may include prioritizing the text from the N binary images according to error rates on a training set. The training set may be a synthetic training set. An apparatus corresponding to the above method is also disclosed herein. | 05-15-2014 |
20140127813 | CYTOPLASMA TO ORGANELLE DELIVERY SYSTEM AND ASSOCIATED METHODS - Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into proximity outside of a cell a lance and a preselected biological material, charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance, and penetrating an outer portion of the cell with the lance and directing and inserting the lance into the cell but outside of the organelle. The method can further include discharging the lance to release at least a portion of the biological material, charging the lance with an opposite polarity and charge sufficient to electrophoretically drive at least a portion of the biological material into the organelle, and withdrawing the lance from the cell. | 05-08-2014 |
20140127446 | AMORPHOUS CARBON AND ALUMINUM MEMBRANE - A membrane including at least one aluminum layer and at least one amorphous carbon layer. At least one polymer layer may also be included. Aluminum layer(s) can provide improved gas impermeability to the membrane. Amorphous carbon layer(s) can provide corrosion resistance. Polymer layer(s) can provide improved structural strength. | 05-08-2014 |
20140118223 | GRAPHICAL VIEW SELECTION SYSTEM, METHOD, AND APPARATUS - A method for selecting a view of a graphical rendering of an object may include (1) rendering an object according to a first view on a first display corresponding to a first user, (2) receiving information regarding a second view of the object on a second display corresponding to a second user, (3) displaying an interface element corresponding to the second view on the first display, (4) rendering the second view of the object on the first display in response to selection of the interface element corresponding to the second view. Various other systems, apparatus, and computer-readable media corresponding to the above method are also disclosed herein. | 05-01-2014 |
20140111800 | HYBRID, PLANAR OPTOFLUIDIC INTEGRATION - An optofluidic platform is constructed to comprise a vertical integration of optical and fluidic layers. The optical layer enables interaction of light with a fluid for a variety of purposes, including particle detection, manipulation, and analysis. The vertical integration allows layers to be permanently or temporarily attached to each other. Temporary attachments provide the advantage of reusing the same optical layer with different fluidic layers. Most preferably, the optical layer comprises antiresonant reflecting optical waveguide. Further, a fluidic layer can be configured to act as an interface between the optical layer and other fluidic layers attached thereon. Moreover, the fluidic layers can be configured to perform fluidic functions. The optofluidic platform can also comprise a protective layer. As such, a liquid solution can be introduced in the optofluidic platform and single particles contained therein can be optically detected with extremely high sensitivity and without the need for advanced microscopy equipment. | 04-24-2014 |
20140107090 | TREATMENT AND PREVENTION OF MASTITIS - Treating and Preventing mastitis employing cationic steroidal antimicrobials (CSAs). Treating or preventing clinical mastitis in a mammal includes administering a cationic steroidal anti-microbial compound (CSA) formulation to the intra-mammary organ of a mammal (e.g., a dairy cow), such as by injection into the mammary organ (e.g., through the teat of the mammary organ), and/or topical application. The dairy cow can be lactating and have a somatic cell count (SCC) less than or equal to 500,000 cells/mL at the time of administering the CSA formulation. Alternatively, the dairy cow can be lactating and have a somatic cell count (SCC) greater than 500,000 cells/mL at the time of administering the CSA formulation. The dairy cow can be taken out of production during the administration of the CSA formulation for a period of time of about 3 days or less, 2 days or less, or 1 day or less. | 04-17-2014 |
20140101602 | METHODS AND APPARATUS RELATED TO EXPANDING OR CONTRACTING REPRESENTATIONS OF DATA - In one general aspect, a non-transitory computer-readable storage medium can be configured to store instructions that when executed cause a processor to perform a process. The process can include receiving an indicator configured to trigger movement of a representation of a first portion of data and a representation of a second portion of data in a direction toward a boundary where the boundary is oriented with respect to a display area. The process can also include modifying a position of the representation of the first portion of data with respect to a position of the representation of second portion of data in response to the indicator. | 04-10-2014 |
20140094900 | COMPLIANT BIOCOMPATIBLE DEVICE AND METHOD OF MANUFACTURE - As detailed herein, a biocompatible apparatus comprises a porous material comprising ceramic nanotubes bound together with a filler material. The proportion of the filler material may be selected to provide porosity for the porous material that is biocompatible, and the porous material may be shaped to provide a compliant biomedical device. In one embodiment, the compliant biomedical device is a stent such as intravascular stent. A method for fabricating a biocompatible device is also described herein. The method may include growing ceramic nanotubes on a substrate, infiltrating the ceramic nanotubes with a filler material to provide a porous material having a porosity that is biocompatible, and removing the porous material from the substrate to provide a biocompatible ceramic device. The method may also include coating the biocompatible ceramic device with a drug-eluting material. | 04-03-2014 |
20140093964 | DELIVERY OF BIOLOGICAL MATERIALS INTO CELLULAR ORGANELLES - Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell. | 04-03-2014 |
20140037693 | 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES - This invention relates to galactosylceramide compounds. | 02-06-2014 |
20140034710 | FRICTION STIR WELDING USING A SUPERABRASIVE TOOL - A probe for friction stir welding MMCs, ferrous alloys, non-ferrous alloys, and superalloys, as well as non-ferrous alloys, the probe including a shank, a shoulder, and a pin disposed through the shoulder and into the shank, wherein the pin and the shoulder at least include a coating comprised of a superabrasive material, the pin and shoulder being designed to reduce stress risers, disposing a collar around a portion of the shoulder and the shank to thereby prevent movement of the shoulder relative to the shank, and incorporating thermal management by providing a thermal flow barrier between the shoulder and the shank, and between the collar and the tool. | 02-06-2014 |
20140008490 | AERIAL RECOVERY OF SMALL AND MICRO AIR VEHICLES - A method, apparatus, system, and computer system to facilitate aerial recovery of an air vehicle are disclosed. In various embodiments, a drogue is established in a drogue recovery orbit and an air vehicle is recovered with the drogue. Establishment of the drogue in a drogue recovery orbit may include establishment of a mothership in a mothership recovery orbit or actuating control surfaces on the drogue. Recovering the air vehicle may include maneuvering the drogue and the air vehicle in a cooperative manner to facilitate recovery of the air vehicle or utilizing a homing device on the drogue to guide the air vehicle. The various techniques disclosed may be modified to compensate for wind. | 01-09-2014 |
20130285160 | Microscale Metallic CNT Templated Devices and Related Methods - A microscale device comprises a patterned forest of vertically grown and aligned carbon nanotubes defining a carbon nanotube forest with the nanotubes having a height defining a thickness of the forest, the patterned forest defining a patterned frame that defines one or more components of a microscale device. A conformal coating of substantially uniform thickness at least partially coats the nanotubes, defining coated nanotubes and connecting adjacent nanotubes together, without substantially filling interstices between individual coated nanotubes. A metallic interstitial material infiltrates the carbon nanotube forest and at least partially fills interstices between individual coated nanotubes. | 10-31-2013 |
20130280391 | ANTI-MICROBIAL WASH COMPOSITIONS INCLUDING CERAGENIN COMPOUNDS AND METHODS OF USE FOR TREATING NON-MEAT FOOD PRODUCTS - Disclosed herein are anti-microbial wash compositions and methods for using such compositions in controlling microbe growth on a non-meat food product (e.g., fruits, vegetables, grains, eggs, etc.) by applying or contacting the anti-microbial wash composition with a surface of the food product to kill microbes (e.g., bacteria) on a surface of the food product. The anti-microbial wash compositions include a ceragenin compound dispersed in a fluid carrier. The ceragenin compound includes a sterol backbone and a number of cationic groups attached to the sterol backbone. The cationic groups may be attached to the sterol backbone by a hydrolysable linkage so that the ceragenin compound has a relatively short half life (e.g., less than about 40 days), and the wash composition may be applied prior to shipping and washed off after shipping to minimize any ceragenin compound residue. | 10-24-2013 |
20130267411 | SINGLE REACTION SYNTHESIS OF TEXTURIZED CATALYSTS - Methods are described for making a texturized catalyst. The textural promoter may be a high-surface area, high-porosity, stable metal oxide support. The catalyst is manufactured by reacting catalyst precursor materials and support materials in a single, solvent deficient reaction to form a catalyst. The catalyst may be particles or a coating or partial coating of a support surface. | 10-10-2013 |
20130266211 | STEREO VISION APPARATUS AND METHOD - A method for stereo vision may include filtering a row or column in a stereo image to obtain intensity profiles, identifying peaks in the intensity profiles, pairing peaks within a maximum disparity distance, determining a shape interval for peak pairs, selecting a peak pair with a maximum shape interval, determining a disparity offset for the peak pairs, extending shape intervals to include all pixels in the intensity profiles, computing depths or distances from disparity offsets, and smoothing the stereo image disparity map along a perpendicular dimension. Another method for stereo vision includes filtering stereo images to intensity profiles, identifying peaks in the intensity profiles, pairing peaks within a maximum disparity distance, determining shape intervals for peak pairs, and selecting peak pairs with the maximum shape interval. Apparatus corresponding to the above methods are also disclosed herein. | 10-10-2013 |
20130244227 | METHOD FOR AMPLIFICATION-FREE NUCLEIC ACID DETECTION ON OPTOFLUIDIC CHIPS - An optofluidic platform is constructed so as to comprise a planar, liquid-core integrated optical waveguides for specific detection of nucleic acids. Most preferably, the optical waveguides comprises antiresonant reflecting optical waveguide (ARROWs). A liquid solution can be prepared and introduced into the optofluidic platform for optical excitation. The resulting optical signal can be collected at the edges of the optofluidic platform and can be analyzed to determine the existence of a single and/or a specific nucleic acid. | 09-19-2013 |
20130243842 | COMPOSITIONS AND METHODS FOR TREATING BONE DISEASES AND BROKEN BONES - Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 09-19-2013 |
20130243823 | METHODS AND PRODUCTS FOR INCREASING THE RATE OF HEALING OF TISSUE WOUNDS - Disclosed are methods for increasing the rate of healing of a tissue wound by administering a composition including a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting wound healing in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of a tissue wound. Kits comprising such compositions and instructions on such methods are also contemplated herein. | 09-19-2013 |
20130239011 | Multi-User Decomposition of Design Space Models - A method for collaborative CAx editing may include enabling a user to define a partitioning constraint for a design space and partitioning the design space into editing regions according to the partitioning constraint and assigning users to specific editing regions. The method may also include displaying a feature tree, enabling a user to select and lock a selected feature for editing by a specified user, enabling the specified user to edit the selected feature and blocking access from other users to the selected feature. An apparatus corresponding to the above method is also disclosed herein. | 09-12-2013 |
20130236619 | ANTI-MICROBIAL FOOD PROCESSING COMPOSITIONS INCLUDING CERAGENIN COMPOUNDS AND METHODS OF USE - Disclosed herein are anti-microbial wash compositions and methods for using such compositions in controlling microbe growth on a meat food product (e.g., a slaughtered meat carcass) by applying or contacting the anti-microbial wash composition with a surface of the food product to kill microbes (e.g., bacteria) on a surface of the food product. The anti-microbial wash compositions include a ceragenin compound dispersed in a fluid carrier. The ceragenin compound includes a sterol backbone and a number of cationic groups attached to the sterol backbone. | 09-12-2013 |
20130224377 | SURFACE FUNCTIONALIZATION OF CARBON NANOTUBES VIA OXIDATION FOR SUBSEQUENT COATING - In an embodiment, a method for manufacturing a chromatography apparatus such as a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), oxidizing the elongated nanostructures to form a surface enriched in oxygen moieties, and at least partially coating the oxidized elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the chromatography apparatus. Embodiments for TLC plates and related methods are also disclosed. | 08-29-2013 |
20130211279 | APPARATUS METHOD AND SYSTEM FOR MEASURING STRAIN IN BIOLOGICAL TISSUE - An apparatus for in-situ sensing of longitudinal and transverse strain in biological tissue (e.g. tendons and ligaments) includes a set of sensing electrodes that contact biological tissue and enable measurement of an electrical property of the biological tissue along two or more directions. The apparatus may also include a sensing module that senses the electrical property of the biological tissue along the two or more directions to provide multi-directional measurements that are captured by a logging module. The apparatus may also include a transmission module that transmits the captured measurements to a data analysis workstation or the like. The data analysis workstation may include a strain estimation module that receives the multi-directional measurement and estimates a longitudinal strain and a transverse strain therefrom. A corresponding system and method for in-situ sensing of longitudinal and transverse strain in biological tissue is also presented. | 08-15-2013 |
20130201747 | PERMANENT SOLID STATE MEMORY USING CARBON-BASED OR METALLIC FUSES - A permanent solid state memory device is disclosed. Recording data in the permanent solid state memory device forms voids in a data layer between a first wire array and a second wire array. Wires of the first wire array extend transversely to wires in the second wire array. The material is made of a carbon allotrope such that when current is passed through the carbon allotrope, the carbon is quickly oxidized (burned) leaving a complete gap (void) where the fuse once was. One of the advantages of this method is that the fuse material is fully oxidized in the particular “neck region of the bowtie”, such that there is no material left over from which dendrites can grow. In other embodiments, the data layer is a metal or metal oxide selected from the following metals: Tungsten (W), Rhenium (Rh), Osmium (Os), Iridium (Ir), Molybdenum (Mo), Ruthenium (Ru), Rhodium (Rh), Chromium (Cr), and Manganese (Mn). | 08-08-2013 |
20130199701 | Integrated Optical Vapor Cell Apparatus for Precision Spectroscopy - An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate. | 08-08-2013 |
20130199262 | SELF CALIBRATING FUEL DISPENSING METHOD AND SYSTEM - Fluid level measurements for the shared tank and outflow information provided by calibrated flow meters corresponding to dispensing stations connected to the shared tank may be used to derive a filled volume model for the tank as a function of fluid level. Subsequently, a filled volume change for a shared tank over a selected time interval may be determined from pre-change and post-change fluid level measurements. The change in filled volume may be compared with the total fluid flow over the selected time interval as indicated by the flow meters of active dispensing stations. If the filled volume change for the tank is substantially different than the total fluid flow indicated by the flow meters, the flow meters may be collectively adjusted to provide a more accurate indication of the filled volume change in the shared tank. | 08-08-2013 |
20130187830 | PLANAR ARRAY FEED FOR SATELLITE COMMUNICATIONS - An apparatus, system, and method are disclosed for wireless communications. A planar antenna element is disposed on a surface of a substrate. The planar antenna element comprises an electrically conductive material and has a circular polarization. The substrate comprises a dielectric material. The planar antenna element may be arranged in a planar antenna array as a feed for a reflector antenna or as an aperture array. The planar antenna element may comprise a slot patch antenna element with a slot in the electrically conductive material of the planar antenna element circumscribing the planar antenna element. The slot exposes the dielectric material of the substrate. A ground plane may be disposed on the surface of the substrate. The ground plane comprises an electrically conductive material. The slot may be disposed between the ground plane and the patch antenna element. | 07-25-2013 |
20130177988 | CYTOPLASM TO ORGANELLE DELIVERY SYSTEM AND ASSOCIATED METHODS - Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into proximity outside of a cell a lance and a preselected biological material, charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance, and penetrating an outer portion of the cell with the lance and directing and inserting the lance into the cell but outside of the organelle. The method can further include discharging the lance to release at least a portion of the biological material, charging the lance with an opposite polarity and charge sufficient to electrophoretically drive at least a portion of the biological material into the organelle, and withdrawing the lance from the cell. | 07-11-2013 |
20130177977 | Systems and Devices for Restraining a Cell and Associated Methods - Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure. | 07-11-2013 |
20130158035 | ANTIMETASTATIC COMPOUNDS - Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor. | 06-20-2013 |
20130130346 | Human Waste Treatment System and Method - A human waste treatment system is disclosed that includes at least one waste receptacle such as an airline-style toilet, an anaerobic digester such as an induced bed reactor, and a gas conditioner. Human waste may be moved by a macerator pump. Inside the digester, bacteria digests organic solids to form biogas. The anaerobic digester may be operated at thermophilic temperatures to kill pathogenic bacteria in the waste and produce treated water. The gas conditioner purifies the biogas which may be used to power an electric generator. Treated water may be used to flush the system. The system may be mounted on a semi-truck trailer and transported. The system may be self-contained. | 05-23-2013 |
20130123357 | Methods for Providing Enhanced Resveratrol Activity Using 4-Acetoxy-Resveratrol - The present invention relates to a method of providing enhanced resveratrol activity comprising: administering a therapeutically effective amount of 4-acetoxy-resveratrol for the treatment of and preventing physiological and pathophysiological conditions mediated by (1) sirtuins, (2) estrogen and anti-estrogen hormone actions and (3) chemical interventions important for male and female health, aging, anti-aging and age-related disorders. | 05-16-2013 |
20130064355 | VARIABLE RADIUS TAPER X-RAY WINDOW SUPPORT STRUCTURE - A support structure for an x-ray window comprising a support frame defining a perimeter and an aperture, a plurality of ribs extending across the aperture of the support frame and carried by the support frame, and openings between the plurality of ribs. A rib taper region can extend from a central portion of the ribs to the support frame. The taper region can include a non-circular, arcuate pair of fillets on opposing sides of the ribs and an increasing of rib width from the central portion to the support frame. | 03-14-2013 |
20130062395 | FRICTION STIR WELDING USING A SUPERABRASIVE TOOL - A probe for friction stir welding MMCs, ferrous alloys, non-ferrous alloys, and superalloys, as well as non-ferrous alloys, the probe including a shank, a shoulder, and a pin disposed through the shoulder and into the shank, wherein the pin and the shoulder at least include a coating comprised of a superabrasive material, the pin and shoulder being designed to reduce stress risers, disposing a collar around a portion of the shoulder and the shank to thereby prevent movement of the shoulder relative to the shank, and incorporating thermal management by providing a thermal flow barrier between the shoulder and the shank, and between the collar and the tool. | 03-14-2013 |
20130035348 | ANTIMETASTATIC COMPOUNDS - Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor. | 02-07-2013 |
20130016914 | WORD WARPING FOR OFFLINE HANDWRITING RECOGNITION - Performing word recognition operations to determine what an image of a word represents. The method includes accessing a first image. The first image represents an image version of a word. The method further includes accessing a second image. The second image also represents an image version of a word. Using a warp mesh, the method includes warping the second image to cause the second image to approximately match the first image by applying a mesh to the second image and moving vertices of the mesh to warp the second image. The difference between the warped second image and the unwarped first image are determined. | 01-17-2013 |
20120306698 | PLANAR ARRAY FEED FOR SATELLITE COMMUNICATIONS - An apparatus, system, and method are disclosed for wireless communications. A planar antenna element is disposed on a surface of a substrate. The planar antenna element comprises an electrically conductive material. The substrate comprises a dielectric material. The planar antenna element may be arranged in a planar antenna array as a feed for a reflector antenna or as an aperture array. The planar antenna element may comprise a slot patch antenna element with a slot in the electrically conductive material of the planar antenna element circumscribing the planar antenna element. The slot exposes the dielectric material of the substrate. A ground plane may be disposed on the surface of the substrate. The ground plane comprises an electrically conductive material. The slot may be disposed between the ground plane and the patch antenna element. The substrate may include electronic components for beam steering, upconversion, downconversion, amplification, or other functions. | 12-06-2012 |
20120301960 | Lance Device and Associated Methods for Delivering a Biological Material Into a Cell - Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell. | 11-29-2012 |
20120297821 | SYSTEMS AND METHODS FOR SEPARATING CONDENSABLE VAPORS FROM LIGHT GASES OR LIQUIDS BY RECRUPERATIVE CRYOGENIC PROCESSES - Methods and systems of the current invention separate condensable vapors such as carbon dioxide from light gases or liquids in a mixed process stream. The separation is carried out in a cryogenic process using one or more external cooling loops (ECLs) that first cool down a mixed process stream containing condensable vapors and light gases or liquids, causing the condensable vapors to desublimate and form solids. Next, the solids are separated from the light gases or liquids, forming a solid stream and a light gas or liquid stream. Then the refrigerants of the ECL are cooled by warming the separated solid stream and light gas or liquid stream, efficiently recovering energy used in cooling and desublimating the condensable vapors. | 11-29-2012 |
20120270815 | MODIFIED-GALACTOSYL CERAMIDES FOR STAINING AND STIMULATING NATURAL KILLER T CELLS - Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells. | 10-25-2012 |
20120264821 | USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 10-18-2012 |
20120200309 | CELL FOR BROADBAND DIELECTRIC SPECTROSCOPY - In one general aspect, an apparatus can include a block defining a temperature control channel therethrough and a defining a sample chamber. The apparatus can also include an electrode disposed inside of the block such that the sample chamber is fluidically isolated from the temperature control channel by the electrode. The electrode can be configured to receive a signal from an impedance analyzer during a dielectric spectroscopy experiment related to a sample included in the sample chamber. | 08-09-2012 |
20120153514 | SYSTEMS AND METHODS FOR SEPARATING CONDENSABLE VAPORS FROM GASES BY DIRECT-CONTACT HEAT EXCHANGE - Condensable vapors such as carbon dioxide are separated from light gases in a process stream. The systems and methods employ a direct exchange heat exchanger to desublimate the condensable vapors from the process stream. The condensable vapors are condensed by directly contacting a heat exchange liquid in the direct contact heat exchanger while the uncondensed light gases from the process stream form a separated light-gas stream. The separated light-gas stream can be used in a recuperative heat exchanger to cool the process stream. | 06-21-2012 |
20120149041 | IDENTIFICATION AND QUANTIFICATION OF BIOMARKERS FOR EVALUATING THE RISK OF PRETERM BIRTH - Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying a first biomarker and a second biomarker associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth. | 06-14-2012 |
20120132072 | METHODS AND SYSTEMS FOR SEPARATING CONDENSABLE VAPORS FROM GASES - Condensable vapors such as carbon dioxide are separated from light gases in a process stream. The systems and methods employ a particle bed cooled by an in-bed heat exchanger to desublimate the condensable vapors from the process stream. The condensable vapors are condensed on the bed particles while the light gases from the process stream, which are not condensed, form a separated light-gas stream. The separated light-gas stream can be used in a recuperative heat exchanger to cool the process stream. | 05-31-2012 |
20120108561 | STORAGE-STABLE, ANTI-MICROBIAL COMPOSITIONS INCLUDING CERAGENIN COMPOUNDS AND METHODS OF USE - Storage-stable, anti-microbial compositions and products include a carrier and a ceragenin compound suspended in the carrier. Ceragenin compounds suspended in the carrier include a sterol backbone and a number of cationic groups attached to the sterol backbone via hydrolysable linkages. The carrier has a pH of 5.5 or less, which acts to stabilize the hydrolysable linkages and increase the shelf-life of the anti-microbial compositions and anti-microbial products. Nevertheless, the ceragenin compounds described herein are designed to break down relatively quickly (e.g., within about 5 days) if the pH environment of the ceragenin compounds is raised to about pH 6.5 or greater. | 05-03-2012 |
20120107382 | ARTICLES INCORPORATING ABSORBENT POLYMER AND CERAGENIN COMPOUND - An absorbent article includes an absorbent polymer and a ceragenin compound. The ceragenin compound has a sterol group and a plurality of cationic groups that mimic naturally occurring antimicrobial peptides. The ceragenin compound is associated with the absorbent polymer such that upon absorption of a fluid, the ceragenin compound is incorporated or maintained in the absorbent article. | 05-03-2012 |
20120028915 | 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES - This invention relates to galactosylceramide compounds. | 02-02-2012 |
20120020879 | PROCESS, COMPOSITION AND METHOD FOR ANION DEPOSITION INTO FERRITIN FOR THERAPEUTIC AND OTHER USE - Provided herein is a process for production of a metal nanoparticle, the process comprising providing a first solution containing a protein nanocage complex comprising a hydrophobic metal core and an ion-transport mechanism, providing a second solution containing a preselected anionic agent, combining the first and second solutions into a third combined solution, and applying an external method to the third combined solution to manipulate the metal core's redox state, in which reduction of the metal core causes the preselected anionic agent to be imported and incorporated into the metal core. Also provided herein is a composition from the process and a method of use. | 01-26-2012 |
20120012470 | METHODS AND APPARATUS FOR ANALYSIS OF CONCRETE COVER IN REINFORCED CONCRETE STRUCTURES SUBJECT TO REINFORCEMENT CORROSION - In one general aspect, a system can include a probe configured to be coupled to a concrete surface of a portion of concrete. The system can include a waveform generator configured to trigger flow of a current to the portion of concrete via the probe and configured to reference a potential of a reinforcing bar embedded within the concrete. The system can also include a current detector configured to detect a magnitude of the current. | 01-19-2012 |
20110257008 | METHOD FOR MAKING HIGHLY POROUS, STABLE METAL OXIDES WITH A CONTROLLED PORE STRUCTURE - Methods for making high-surface area, high-porosity, stable metal oxides, such as, but not limited to materials used as adsorbents and catalyst supports include (i) forming a solvent deficient precursor mixture from a metal salt and a base and reacting the metal ions and base ions in the solvent deficient precursor mixture to form an intermediate hydroxide product (e.g., metal hydroxide or metal oxide hydroxide), (ii) causing the intermediate hydroxide to form nanoparticles (e.g., by heating), and (iii) calcining the intermediate nanoparticles to sinter the nanoparticles together and yield a highly porous, stable metal oxide aggregate having a pore structure. | 10-20-2011 |
20110253295 | Integrated Optical Vapor Cell Apparatus for Precision Spectroscopy - An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate. | 10-20-2011 |
20110247404 | IDENTIFYING AND QUANTIFYING BIOMARKERS ASSOCIATED WITH PREECLAMPSIA - Described herein are methods for testing pregnant subjects for preeclampsia by detecting and quantifying at least one biomarker associated with preeclampsia in a biological sample from the subject. | 10-13-2011 |
20110228971 | ROBUST WATERMARKING FOR DIGITAL MEDIA - Embedding a watermark includes organizing variation locations in a data stream, partitioning the data stream into small blocks, determining the variation of small blocks based on the variation, categorizing small blocks into big blocks, identifying those big blocks that have a threshold level of variation, and embedding into those identified big blocks a watermark value. | 09-22-2011 |
20110226010 | CARBON DIOXIDE CAPTURE FROM FLUE GAS - A method for capturing carbon dioxide from a flue gas includes (i) removing moisture from a flue gas to yield a dried flue gas; (ii) compressing the dried flue gas to yield a compressed gas stream; (iii) reducing the temperature of the compressed gas stream to a temperature T | 09-22-2011 |
20110210056 | GAS PHASE APPROACH TO IN-SITU/EX-SITU FUNCTIONALIZATION OF POROUS GRAPHITIC CARBON VIA RADICAL-GENERATED MOLECULES - Embodiments disclosed herein include graphitic stationary phase materials functionalized through a gas-phase functionalization reaction, as well as and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be prepared from high surface area porous graphitic carbon and a radical forming volatilized functionalizing agent. The radical forming volatilized functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon. | 09-01-2011 |
20110192779 | THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to acidified water vapor or immersion in a concentrated acid bath (e.g., HCl and methanol). At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed. | 08-11-2011 |
20110183206 | APPARATUS, SYSTEM, AND METHOD FOR CARBON NANOTUBE TEMPLATED BATTERY ELECTRODES - An apparatus, system, and method are disclosed for a carbon nanotube templated battery electrode. The apparatus includes a substrate, and a plurality of catalyst areas extending upward from the substrate, the plurality of catalyst areas forming a patterned frame. The apparatus also includes a carbon nanotube forest grown on each of the plurality of catalyst areas and extending upward therefrom such that a shape of the patterned frame is maintained, and a coating attached to each carbon nanotube in the carbon nanotube forest, the coating formed of an electrochemically active material. The system includes the apparatus, and a particulate cathode material distributed evenly across the apparatus such that the particulate cathode material fills the passages, a current collector film formed on top of the particulate cathode material, and a porous spacer disposed between the apparatus and the cathode. | 07-28-2011 |
20110176996 | COMPOSITIONS AND METHODS FOR CANCER MANAGEMENT USING ANTIBODIES BINDING TO NUCLEOTIDE SALVAGE PATHWAY ENZYMES AND COMPLEXES THEREOF - Compositions and methods are provided for the diagnosis, treatment, and medical management of cancers. The methods include the use of antibodies and other binding molecules that specifically bind to one or more nucleotide salvage pathway enzymes (SPEs) selected from the group consisting of adenine phosphoribosyltransferase (APRT), hypoxanthine-guanine phosphoribosyltransferase (HGPRT), deoxycytidine kinase (dCK); and thymidine kinase 1 (TK1) and complexes comprising SPEs, for detection of the SPE(s) on or in cancer cells and/or on or in body fluids and tissues of cancer patients. Binding of SPEs is useful in the methods provided herein for diagnosing cancer, determining prognosis of cancer and assessing the effectiveness of cancer treatments. Immunoassay systems for use in the methods are also provided, including sandwich immunoassays. In addition, an amino acid sequence comprising a novel TK1 binding site is provided, as well as nucleotide sequences encoding it. | 07-21-2011 |
20110158076 | DIGITAL INFORMATION MEDIA HAVING ADHESION PROMOTION LAYER ON A SUBSTRATE - Disclosed is a digital information media having an adhesion promotion layer supported on a dummy (L1) substrate that enables secure bonding of the L1 layer, directly or indirectly, to the rest of the stack of layers in the digital information media. Certain materials including metals, metal alloys, or metalloids enhance adhesion between the adhesive layer and the L1. By applying an adhesion promotion layer of such materials on an inner surface of the L1, the bond between the adhesive and the adhesion promotion layer improves bonding and reduces a tendency for the L1 to delaminate from the rest of the stack. The tendency for breakage of the media at the juncture between the adhesion promotion layer and the adhesive is reduced, and incursion of moisture or oxygen through the interface between the adhesion promotion layer and the adhesive is inhibited. | 06-30-2011 |
20110117619 | Method for Pretreatment of Cellulosic and Lignocellulosic Materials for Conversion into Bioenergy - A process for converting organic waste materials into usable products and products thereof is disclosed. According to the process, organic waste materials are contacted with an oxidant to form a product and then an amount of the oxidant is removed from the product to form a reactor-ready feedstock. The oxidant is removed by various means, including washing, photolysis, catalytic means, oxidation of the oxidant, reduction of the oxidant, and heat. The reactor-ready feedstock may then be introduced into a reactor, such as a digester or incubator, and the reactor-ready feedstock is converted by microorganisms into biofuel or other products. | 05-19-2011 |
20110104258 | TECHNIQUE FOR DRUG AND GENE DELIVERY TO THE CELL CYTOSOL - Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the group consisting of endocytosis, pinocytosis or phagocytosis, the liposome comprising a phase transforming liquid with vapor pressure capable of forming a gas at low pressure, said liquid being associated with the liposome, and the liposome further comprising at least one functional molecule selected from the group consisting of a therapeutic molecule, a detectable label, and a targeting molecule. | 05-05-2011 |
20110091376 | CATATONIC STEROID ANTIMICROBIAL DIAGNOSTIC, DETECTION, SCREENING AND IMAGING METHODS - The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging include administering a cationic steroid antimicrobial or CSA to a subject having or at risk of having an infection or a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in an amount effective to diagnose or detect the infection or the hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject. In a particular aspect, a detectable CSA, namely CSA-13 labeled with | 04-21-2011 |
20110089096 | THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed. | 04-21-2011 |
20110082106 | METHODS OF ACTIVATING NKT CELLS - Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided. | 04-07-2011 |
20110073634 | THREE-BODY JOINING USING FRICTION STIR PROCESSING TECHNIQUES - A friction stir tool is provided to perform friction stir riveting using a partially consumable pin, wherein the pin includes a cutting edge on a bottom surface thereof, wherein the tool is rotated at a first speed to enable cutting by the pin into a first material that is overlapping a second material, wherein after the pin has cut to a sufficient depth, the rotational speed of the tool is increased to thereby enable plasticization of the consumable pin, the first material, and the second material, wherein the tool is then rapidly decelerated until stopped, enabling diffusion bonding between the pin, the first material and the second material. | 03-31-2011 |
20110061385 | METHODS AND SYSTEMS FOR GENERATING POWER FROM A TURBINE USING PRESSURIZED NITROGEN - An air separation unit is integrated with a power generating plant to improve the efficiency of power generation. The methods and systems improve the efficiency of power generation by utilizing liquid nitrogen from the air separation unit as the working fluid in a turbine. The liquid nitrogen is pressurized while in the liquid state. After warming the pressurized nitrogen stream by cooling the air for the air separator unit, the compressed nitrogen is expanded in a turbine to perform work. After expansion, the nitrogen is vented to ambient air. The nitrogen in its pressurized state can be used for energy storage and/or for smoothing out power demand on a power grid. | 03-17-2011 |
20110056373 | METHODS FOR STABLE SEQUESTRATION OF CARBON DIOXIDE IN AN AQUIFER - The methods disclosed herein relate to sequestering carbon dioxide in an aquifer by trapping the CO | 03-10-2011 |
20110054573 | SYSTEM AND METHOD FOR TREATING SYMPTOMS OF RESTLESS LEGS SYNDROME - Disclosed herein are systems and methods for reducing effects of restless legs syndrome (RLS) in a subject. The method includes identifying, on the subject, a body region affected by RLS, placing an emitter unit in direct contact with skin of the body region, wherein the emitter unit includes at least one emitter that emits near-infrared light, and activating the emitter to emit an effective amount of near-infrared light for inducing release of nitric oxide from hemoglobin or generation in the endothelium. Also disclosed is an emitter unit that is placed in direct contact with a subject's skin associated with RLS to reduce the effects of RLS. The emitter unit emits an effective amount of near-infrared light directed to the subject's skin to induce release of nitric oxide from hemoglobin or generation in the endothelium, and a module configured to toggle the emitter unit between a transmitting and a nontransmitting mode. | 03-03-2011 |
20110041689 | OFF GAS PURIFICATION - Heat-exchangers and biogas conditioners including a heat exchange member disposed between upper and lower flanges of the apparatus in which at least the heat exchange member is formed of a highly thermally conductive material (e.g., at least 50 W/m−K) such as aluminum or aluminum alloy. A bed of zeolite is loaded within the apparatus so as to be in contact with the heat exchange member. The heat exchange member is shaped and configured so that any given location of the zeolite bed is no more than about 3 inches from the heat exchange member comprising the highly thermally conductive material. | 02-24-2011 |
20110027323 | ADJUVANTS AND METHODS OF USE - Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds. | 02-03-2011 |
20110000852 | THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. Embodiments for TLC plates and related methods are also disclosed. | 01-06-2011 |
20100325577 | WINDOW BROKER ARCHITECTURE - Retrieving information from a display server. Information about all visible windows displayed on a display by the display server is retrieved. Descriptive information about visible windows displayed on the display, and windows on a shelf is retrieved from the display server or window broker. Notifications of changes to windows are received. Based on information retrieved from the display server or window broker and received notifications, a user interface displays windows displayed on the display and windows on the shelf. A user request is received at the user interface for a change to what is displayed by the display server. The user request is sent, directly or indirectly to the window broker. The window broker approves, denies or makes arbitrary changes to windows to accommodate the user request and sends a window broker request to the display server. The window broker notifies window managers of changes that have been made. | 12-23-2010 |
20100325576 | DISTRIBUTING MULTIPLE CLIENT WINDOWS USING A DISPLAY SERVER - Displaying overlapping windows from a client device. Windows are displayed at a client device with a first window overlapping a second window on a single display. The first window is a current window. The current window is based on front to back ordering of windows displayed at the client device. Pixels in a region of the first window are captured and sent to a display server. At the display server, the first window is displayed on a first display region. The second window becomes the current window, resulting in capturing and sending pixels in a region of the second window to the display server. At the display server, the second window is displayed on a second display region. At the display server, the first and second windows are displayed in a non-overlapping fashion by displaying the first window and the second window on separate display regions | 12-23-2010 |
20100325574 | PRESENTATION SCRATCH SPACES - Implementing scratch spaces to display one or more windows or slides previously streamed while displaying a currently streamed window or slide. A method includes using at least one of a plurality of screens, displaying a source window or slide. A first scratch space location is identified. The first scratch space location is a special window intended to contain a copy of pixels taken from a source window. The method further includes determining that the source window or slide should be copied to the first scratch space location either by detecting user input selecting an accelerator or by identifying a trigger image. As a result of determining that the source window or slide should be copied to the first scratch space location, pixels of the source window or slide are copied to the first scratch space location. | 12-23-2010 |
20100266495 | Anti-Cancer Activity of an Anti-Thymidine Kinase Monoclonal Antibody - Methods of diagnosing and treating cancers that overexpress thymidine kinase 1 on their cell surfaces are provided. These methods utilize monoclonal antibodies that bind specifically to thymidine kinase 1 to inhibit or prevent proliferation of the cancer cells. | 10-21-2010 |
20100241847 | ENCRYPTED EMAIL BASED UPON TRUSTED OVERLAYS - Sending and receiving encrypted emails. At a web browser, user input is received requesting a compose email page user interface for a web-based email system. The compose email page user interface is requested from a server for the web-based mail system. Web page code is received from the server for the compose email page user interface. The web page code for the compose email page user interface is parsed to determine screen locations of one or more user input interface elements. The compose email page user interface is rendered in the browser. One or more browser-based interface elements implemented integral to the browser are overlaid onto the compose email page user interface. User input is received in the browser user interface elements. The user input received is encrypted. The encrypted user input is transferred into one or more elements of the compose email page user interface. | 09-23-2010 |
20100228770 | GENEALOGY CONTEXT PRESERVATION - Preserving context and providing suggestions for genealogy searching. A method includes storing in a storage medium previous user interaction with a genealogical research system from a previous genealogical research session. Initiation of a new genealogical research session is detected. In response to the new research session and based on the previous user interaction with the research system, the system provides suggestions for continuing genealogical research. | 09-09-2010 |
20100221481 | OPTICAL DATA STORAGE MEDIA CONTAINING SUBSTANTIALLY INERT LOW MELTING TEMPERATURE DATA LAYER - Optical information media that contain a data layer material that is substantially inert to oxidation and has a defined melting point range are disclosed. The inertness to oxidation and melting point range make the media particularly attractive for long-term information storage. | 09-02-2010 |
20100213131 | POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES - In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction. | 08-26-2010 |
20100195468 | OPTICAL DATA STORAGE MEDIA CONTAINING METAL AND METAL OXIDE DARK LAYER STRUCTURE - Optical data storage media containing a “dark” layer structure are disclosed. Layered metals and metal oxides provide a dark background that enhances detection of changes in the data layer of the storage media. Combinations such as chromium metal and chromium oxide, and molybdenum metal and molybdenum oxide are offered as examples of suitable materials. | 08-05-2010 |
20100185006 | NOVEL SIRTUIN ACTIVATING COMPOUNDS AND PROCESSES FOR MAKING THE SAME - The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from P | 07-22-2010 |
20100182894 | OPTICAL DATA STORAGE MEDIA CONTAINING AN ENCAPSULATED DATA LAYER - Optical information media containing encapsulated data layers are disclosed. Selective layering of materials in inner radial, middle radial, and outer radial zones allows for the faces and edges of at least the data layers to be encapsulated by other materials, resulting in increased resistance to harmful environmental agents such as oxygen and moisture. | 07-22-2010 |
20100163721 | SERUM PROTEOMICS SYSTEM AND ASSOCIATED METHODS - Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum. | 07-01-2010 |
20100151356 | FUEL CELL AND METHOD FOR GENERATING ELECTRIC POWER - A non-microbial fuel cell utilizing an organic fuel containing a hydroxyl group and a non-metallic catalyst is disclosed. Compositions for use in and methods for generating electric energy from chemical energy using fuel cells are also disclosed. Compositions for use in and methods of storing energy using fuel cells are also disclosed. | 06-17-2010 |
20100137231 | 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES - This invention relates to galactosylceramide compounds. | 06-03-2010 |
20100135147 | HIGH POWER OPTICAL DISC DRIVES - High power optical disc drives are disclosed. The drives are configured to deliver laser energy having a power of at least about 25 mW as measured at DVD 1X write speed upon first contact with the surface of an optical disc. | 06-03-2010 |
20100115436 | FORM-BASED ONTOLOGY CREATION AND INFORMATION HARVESTING - Extracting data from web pages. User input is received defining a tabular form. User input is received correlating portions of the form with user selected data items contained in one or more first web pages. The user input is correlated to create an ontology defining relationships between the user selected data items based on the definition of the tabular form. One or more other web pages are accessed, and based on a context of the one or more data items in the first web page being similar to a context of the selected data items in the one or more first web pages, one or more similar data items are extracted from the one or more other web pages. The extracted data items are correlated to each other in accordance with the ontology defining relationships between the user selected data items and are output as a user searchable data structure. | 05-06-2010 |
20100114902 | HIDDEN-WEB TABLE INTERPRETATION, CONCEPTULIZATION AND SEMANTIC ANNOTATION - Indexing hidden web information. First and second web pages are accessed, which include data organized in table format. The tables from the first and second web page are compared. Based on the comparison, a determination is made as to which table cells contain category labels and which contain instance data. The category labels from the first web page are compared to the category labels from the second web page. A general structure of individual tables is inferred based on the act of comparing the category labels. The general structure is chosen from among standard table templates. Data in two or more web pages organized according to the selected table templates is identified. Data from the two or more web pages is stored by associating the table data from two or more web pages to one or more of the selected table templates. | 05-06-2010 |
20100110860 | DATA STORAGE MEDIA CONTAINING MAGNESIUM METAL LAYER - Optical information media containing a magnesium metal layer and a reactive material layer are disclosed. The magnesium metal can react directly with the reactive material layer, or with a chemical evolved from the reactive material layer after application of energy from a source such as a laser. | 05-06-2010 |
20100103795 | DATA STORAGE MEDIA CONTAINING INORGANIC NANOMATERIAL DATA LAYER - Optical information media having a support substrate and an inorganic nanomaterial data layer are disclosed. The data layer provides enhanced stability and optical performance as compared to conventional data layers. | 04-29-2010 |
20100087519 | USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 04-08-2010 |
20100072137 | FUNCTIONALIZED GRAPHITIC STATIONARY PHASE AND METHODS FOR MAKING AND USING SAME - Embodiments disclosed herein include functionalized graphitic stationary phase materials and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be manufactured from high surface area porous graphitic carbon and a radical forming functionalizing agent. The radical forming functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon. | 03-25-2010 |
20100068445 | Optical Data Media Containing An Ultraviolet Protection Layer - Optical information media containing an ultraviolet protection layer are described. The protection layer will reduce or eliminate damage to the media's data layer and substrate. | 03-18-2010 |
20100056740 | ADSORPTION-RESISTANT ACRYLIC COPOLYMER FOR FLUIDIC DEVICES - A copolymer is used for fluidic devices that require surfaces nonreactive with biomolecules. The copolymer is the reaction product of Compound A having the formula: | 03-04-2010 |
20090277839 | POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES - In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography, and solid phase extraction. | 11-12-2009 |
20090231978 | LONG-TERM DIGITAL DATA STORAGE - Embodiments are directed to recording digital data on an optically ablatable digital storage media. In one embodiment, a device configured to ablate portions of ablatable material on an optically ablatable digital storage media receives digital data that is to be recorded on a recording layer of an optically ablatable digital storage media. The recording layer is formed on a substrate with zero or more intervening layers between the recording layer and the substrate. The recording layer includes ablatable material capable of storing digital data. The device ablates the ablatable material in the recording layer according to a sequence defined by the received digital data such that the ablated portions correspond to data points of the received digital data. | 09-17-2009 |
20090221773 | METHODS FOR DIRECT ATTACHMENT OF POLYMERS TO DIAMOND SURFACES AND DIAMOND ARTICLES - A method for forming a polymer on a substrate is disclosed. The method may include providing a substrate having a substrate surface, the substrate surface being at least partially hydrogen-terminated and reacting the substrate surface in a solution comprising at least one radical initiator and at least one monomer to form a polymer on the substrate surface. The monomer may comprise at least one of a monofunctional monomer and a polyfunctional monomer. A stationary phase for use in separation applications such as chromatography and solid-phase extraction is also disclosed. The stationary phase may include a plurality of diamond bodies and a polymeric compound covalently bonded to at least a surface portion of the plurality of diamond particles. | 09-03-2009 |
20090218276 | FUNCTIONALIZED DIAMOND PARTICLES AND METHODS FOR PREPARING THE SAME - A functionalized particle is disclosed. The functionalized particle may include a diamond-particle substrate and a coating comprising at least one polymeric compound on at least a surface portion of the diamond-particle substrate, the at least one polymeric compound having at least one amine group. Additionally, the at least one polymeric compound may be at least partially reacted. The at least one polymeric compound may also be at least partially cured. The diamond substrate may be porous. In addition, a second coating coupled to at least a surface portion of the first coating. A separation apparatus may have a stationary phase including a plurality of diamond particles and a coating comprising at least one polymeric compound on at least a surface portion of the plurality of diamond particles is also disclosed. A method for forming a functionalized particle is also disclosed. | 09-03-2009 |
20080320205 | LONG-TERM DIGITAL DATA STORAGE - Embodiments are directed to recording digital data on an optically ablatable digital storage media. In one embodiment, a device configured to ablate portions of ablatable material on an optically ablatable digital storage media receives digital data that is to be recorded on a recording layer of an optically ablatable digital storage media. The recording layer is formed on a substrate with zero or more intervening layers between the recording layer and the substrate. The recording layer includes ablatable material capable of storing digital data. The device ablates the ablatable material in the recording layer according to a sequence defined by the received digital data such that the ablated portions correspond to data points of the received digital data. | 12-25-2008 |
20080279894 | Bacterial Glycolipid Activation of Cd1d-Restricted Nkt Cells - Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria. | 11-13-2008 |
20080278710 | Integrated Optical Vapor Cell Apparatus for Precision Spectroscopy - An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate. | 11-13-2008 |
20080207891 | Methods For Selective N-9 Glycosylation of Purines - A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs. | 08-28-2008 |