ALCON RESEARCH, LTD. Patent applications |
Patent application number | Title | Published |
20150313755 | OPHTHALMIC SURGICAL INSTRUMENT WITH INTERNAL FRAME AND EXTERNAL COATING - A method of manufacturing a surgical device can include generating a first internal frame defining an internal structure of an instrument tip; covering at least a portion of the first internal frame with a first coating to define an exterior surface of the instrument tip; and generating an instrument body such that a proximal end of the instrument tip is positioned at a distal end of the instrument body. An ophthalmic surgical instrument can include an instrument body; and an instrument tip disposed at a distal end of the instrument body, the instrument tip including a first section linearly extending along a longitudinal axis of the instrument body and a second section extending obliquely from the first section, the second section being arcuately shaped; and wherein the instrument tip comprises a first internal frame and a first coating covering the first internal frame. | 11-05-2015 |
20150257931 | Remote Magnetic Driven Flow System - A system for implantation in an eye of a patient includes a flow device sized for implantation into the eye of the patient. The flow device includes a fluid flow passageway and a flow system. The flow system may include a regulator having a magnetic element, and may be displaceable in the fluid flow passageway to affect flow through the fluid flow passageway. The system may also include a control device physically separate from the flow device and configured to be disposed outside the eye, the control device comprising an actuator magnetic field generator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the flow device in response to changes in intraocular pressure. | 09-17-2015 |
20150257930 | Debris Clearance System for an Ocular Implant - An IOP control system for treatment of an ocular condition includes a drainage device sized for implantation into the eye of the patient, the drainage device including a fluid flow pathway to allow the flow of fluid from an inlet port to an outlet port. The drainage device also includes a flow system disposed within the drainage device and including a displaceable portion forming a part of the fluid flow pathway, the displaceable portion being displaceable via a magnetic field. An actuation system may be physically separate from the drainage device and may be configured to cooperate with the displaceable portion to displace the displaceable portion via the magnetic field to set free buildup or debris in the flow pathway. | 09-17-2015 |
20150209466 | Phospholipid Compositions for Contact Lens Care and Preservation of Pharmaceutical Compositions - The use of certain synthetic phospholipids to preserve pharmaceutical compositions from microbial contamination is described. The synthetic phospholipids have unique molecular arrangements wherein a phosphate group is linked to a quaternary ammonium functionality via a substituted-propenyl group, and the quaternary ammonium functionality is further linked to at least one long hydrocarbon chain. Such molecular arrangements are what make the phospholipids of formula (I) highly water soluble, e.g., the length of the hydrocarbon chain assists to maintain solubility and efficacy of the molecules for the uses described herein. The synthetic phospholipids described herein have been found to be particularly useful as antimicrobial preservatives for ophthalmic, otic and nasal pharmaceutical compositions, especially ophthalmic compositions. These compounds may also be utilized to disinfect contact lenses. The invention is based in-part upon a finding that the antimicrobial activity of the synthetic phospholipids is affected by the ionic strength of the compositions in which the compounds are contained. The provision of compounds having limited ionic strengths is therefore preferred. | 07-30-2015 |
20150173644 | Marker-Based Tool Tracking - An ophthalmic surgical tool has a marker positioned at a distal portion of the ophthalmic surgical tool. The distal portion of the ophthalmic surgical tool is inserted into an eye along with the marker to perform surgeries in the eye. An imaging device captures images of the fundus of the eye including the distal portion of the ophthalmic surgical tool. An image processor processes the captured images to identify and extract the marker from the captured images. The marker has a high-contrast feature in a visible light or infrared light range or other spectral ranges. Thus, the image processor may identify and extract the marker from the captured images. Indicators may be generated based on the marker and be overlaid with the captured or processed images of the fundus and displayed to a user to indicate surgical information to the user. | 06-25-2015 |
20150157502 | Forward-Flow Impeding Infusion Sleeve and Associated Systems and Methods - An infusion sleeve for use in partially covering a phacoemulsification tip during a surgical operation is disclosed herein. The infusion sleeve includes a flexible elongate portion having a lumen extending therethrough with the phacoemulsification tip running through the lumen. The flexible elongate member further includes a lateral port configured on a side of the flexible elongate member, a straight section, and a tapered section. The tapered section is located at a distal portion of the flexible elongate member and has a first wall subsection having a uniform thickness and a second wall subsection having thickness larger than the uniform thickness. The second wall subsection flexes to maintain circumferential contact with the phacoemulsification tip. | 06-11-2015 |
20150157501 | Devices, Systems, and Methods for Tip Vacuum Control During Aspiration - Disclosed herein is an apparatus for insertion in an eye of a patient for aspirating material from the eye in the treatment of an ocular condition, the apparatus comprising a needle disposed at a distal end of the apparatus, an aspiration channel extending from a distal aperture of the needle to a proximal end of the apparatus, and an irrigation sleeve coaxially disposed about the needle. The aspiration channel comprises a proximal portion having a first diameter, a bypass portion having a second diameter and at least one bypass port, and a distal portion having a third diameter. The second diameter is larger than the first diameter. The irrigation sleeve and the needle form an annular irrigation passageway therebetween. The bypass port is shaped and configured to establish fluid communication between the irrigation passageway and the aspiration channel. | 06-11-2015 |
20150150546 | Surgical Utility Connector - A surgical utility connector is detectable by a surgical utility supplying device to indicate connection with the surgical utility supplying device. The surgical utility connector includes a first connecting region, a second connecting region, and a detection region between the first connecting region and the second connecting region. A utility channel may pass a utility from the surgical utility supplying device. The utility channel may extend through the first connecting region, the detection region, and the second connecting region. The surgical utility connector also may include a magnetic element disposed in the detection region and surrounding the utility channel. The magnetic element may have a field detectable by the surgical utility supplying device when the surgical utility connector is connected to the surgical utility supplying device. | 06-04-2015 |
20150077705 | Integrated OCT-Refractometer System for Ocular Biometry - A Slit-lamp-or-Microscope-Integrated-OCT-Refractometer system includes an eye-visualization system, configured to provide a visual image of an imaged region in an eye; an Optical Coherence Tomographic (OCT) imaging system, configured to generate an OCT image of the imaged region; a refractometer, configured to generate a refractive mapping of the imaged region; and an analyzer, configured to determine refractive characteristics of the eye based on the OCT image and the refractive mapping, wherein the refractometer and the OCT imaging system are integrated into the eye visualization system. | 03-19-2015 |
20150057597 | EXTERNALLY ADJUSTABLE PASSIVE DRAINAGE DEVICE - Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway. | 02-26-2015 |
20150057596 | PASSIVE TO ACTIVE STAGED DRAINAGE DEVICE - Described herein is an IOP control system for implantation in an eye of a patient, comprising a drainage device and a control device. The drainage system includes a housing including an inlet port and an outlet port, a fluid flow passageway extending from the inlet port to the outlet port to allow the flow of fluid therethrough, and at least one valve disposed within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing sides. The control device comprises an actuator including an activated mode and a deactivated mode, and the actuator in the activated mode is configured to selectively adjust flow through the drainage device in response to changes in intraocular pressure. | 02-26-2015 |
20150057595 | PRESSURE-BASED FLOW RATE MEASUREMENT FOR OCULAR IMPLANTS - Described herein is an IOP control device for implantation in an eye of a patient, comprising a drainage tube, a pressure-driven flow system, and a flow rate measurement system. The drainage tube includes a drainage lumen in fluid communication with an anterior chamber of the eye. The flow system is in fluid communication with the drainage lumen, and is configured to control the flow of fluid through the drainage tube. The flow rate measurement system is disposed distal to the flow system, and comprises a flow tube including a known hydraulic resistance to flow, a proximal pressure sensor disposed at the proximal end of the flow tube, and a distal pressure sensor disposed at the distal end of the flow tube. The flow tube includes a proximal end, a distal end, and a lumen extending therebetween that is configured to be in fluid communication with the drainage lumen. | 02-26-2015 |
20150057594 | BUBBLE-FREE MICROFLUIDIC VALVE SYSTEMS AND METHODS - A microfluidic valve for implantation in an eye of a patient is disclosed. The valve may include a chamber formed between a substrate and a flexible membrane. The valve may also include a boss disposed in the chamber and having a top edge in selective contact with the flexible membrane. The top edge includes a relief portion and a non-relief portion, with the relief portion being structurally arranged so that a pressure required to separate the membrane from the relief portion is less than a pressure required to separate the membrane from the non-relief portion. The valve also may include an inlet extending through the boss and the substrate through which fluid enters the chamber and an outlet configured to allow fluid to exit the chamber. Methods for priming a microfluidic valve are also disclosed. | 02-26-2015 |
20150057593 | SYSTEMS AND METHODS FOR PRIMING A MICROFLUIDIC CHAMBER - An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein. | 02-26-2015 |
20150057592 | MEMS CHECK VALVE CHIP AND METHODS - A MEMS check valve chip is described. The chip comprises a first side and an opposing second side, an outlet port extending from the first side to the second side, and a flexible outlet membrane anchored to the first side to overlie the outlet port. The flexible outlet membrane includes an outlet aperture and a sealing portion, and the sealing portion is movable between a closed position inhibiting fluid flow through the outlet aperture and an open position wherein the sealing portion displaces into the outlet port to permit fluid flow through the outlet aperture. | 02-26-2015 |
20150057583 | TRABECULAR MESHWORK STIMULATION DEVICE - An implantable device for mechanically stimulating the trabecular meshwork is disclosed. The device is implanted in the eye adjacent the trabecular meshwork. The device imparts mechanical stimulating in the form of vibrations or movement to the trabecular meshwork. The imparted mechanical stimulation causes the trabecular meshwork to move in a manner that produces a pumping action to remove aqueous from the anterior chamber of the eye. | 02-26-2015 |
20150057524 | SYSTEMS AND METHODS FOR INTRA-OPERATIVE EYE BIOMETRY OR REFRACTIVE MEASUREMENT - Systems and methods for capturing intraoperative biometry and/or refractive measurements include a sensor or valve associated with the eye and configured to detect a pressure of the eye. The system also includes an intra-op diagnostics device including a control unit arranged to actuate the intra-op diagnostics device to capture the intraoperative biometry and/or refractive measurements when the sensor or valve detects pressure within a predetermined pressure range. | 02-26-2015 |
20150057523 | SYSTEMS AND METHODS FOR PRIMING AN INTRAOCULAR PRESSURE SENSOR CHAMBER - An intraocular pressure monitoring and sensing device for implantation in an eye of a patient may include a substrate having a pressure sensor disposed on a top surface thereof and a pressure sensor cap disposed on the substrate over the pressure sensor. The pressure sensor cap may include a wall structure extending from the top surface of the substrate, the wall structure laterally surrounding the pressure sensor. The pressure sensor cap may further include a cap top situated above the pressure sensor, the cap top and wall structure together forming an interior chamber, and a chamber inlet providing fluid access to the interior chamber. At least one of the cap top and the wall structure includes a semi-permeable surface to aid in priming. | 02-26-2015 |
20140371267 | OPHTHALMIC COMPOSITION WITH NITRIC OXIDE DONOR COMPOUND AND METHOD OF FORMING AND USING SAME - The present invention is directed to the provision of ophthalmic compositions such as multi-dose, topical, ophthalmic compositions. The compositions include a nitric oxide (NO) donor compound. | 12-18-2014 |
20140364886 | VITRECTOMY PROBE WITH ADJUSTABLE CUTTER PORT SIZE - Vitrectomy probes and system related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having an adjustable cutting port size. Various example features are described for adjusting the size of the cutting port. Further, the disclosure provides examples for adjusting the size of the cutter port while the vitrectomy probe is in operation. | 12-11-2014 |
20140364480 | RNAi-MEDIATED INHIBITION OF IGF1R FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of IGF1R mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions. | 12-11-2014 |
20140357696 | RNAi-RELATED INHIBITION OF TNF alpha SIGNALING PATHWAY FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy. | 12-04-2014 |
20140357695 | RNAi-MEDIATED INHIBITION OF SPLEEN TYROSINE KINASE-RELATED INFLAMMATORY CONDITIONS - RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease. | 12-04-2014 |
20140357694 | RNAi-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR ALPHA-RELATED CONDITIONS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example. | 12-04-2014 |
20140333978 | FORWARD SCANNING OPTICAL PROBES WITH ONE OR MORE ROTATING COMPONENTS - In certain embodiments, a scanning system comprises optical elements and a movement system. The optical elements comprise an optical fiber and a focusing element. The optical fiber transmits a light ray and has a fiber axis that extends to an imaginary fiber axis. The focusing element refracts the light ray and has a focusing element optical axis that is substantially aligned with the imaginary fiber axis. The movement system rotates the focusing element about the focusing element optical axis to scan the light ray. In other embodiments, a scanning system comprises optical elements and a movement system. The optical elements comprise an optical fiber, a focusing element, and a prism. The prism has a prism optical axis and receives the light ray from the focusing element. The movement system rotates the prism about the prism optical axis to scan the light ray. | 11-13-2014 |
20140323953 | Partial Venting System for Occlusion Surge Mitigation - A surgical system comprises a hand piece, an irrigation conduit in fluid communication with the hand piece to carry fluid toward a surgical site, an aspiration conduit in fluid communication with the hand piece to carry fluid away from the surgical site, a pump interfacing with the aspiration conduit, the pump to create a vacuum pressure in the aspiration conduit to draw fluid through the aspiration conduit, a vacuum relief valve in fluid communication with the aspiration conduit to relieve the vacuum pressure in the aspiration conduit, a pressure sensor to detect a pressure associated with the surgical site, a controller in communication with the vacuum relief valve and the pressure sensor to control the vacuum relief valve to decrease the vacuum pressure in the aspiration conduit when the pressure detected by the pressure sensor is less than a first pressure threshold. | 10-30-2014 |
20140307078 | Method and System to Detect Ophthalmic Tissue Structure and Pathologies - A method to determine an ophthalmic tissue structure comprises measuring image data for a range of depths corresponding to a target point in an eye with an axial scanner with a probe; determining an image information by an imaging processor from the image data; identifying a tissue pathology corresponding to the target point by the processor from the image information; and signaling a user by a user indicator based on the identified tissue pathology. A corresponding apparatus comprises an axial scanner with a probe to measure image data for a range of depths corresponding to a target point in an eye; a processor to determine an image information from the image data, and to identify a tissue pathology corresponding to the target point from the image information; and a user indicator to signal a user based on the identified tissue pathology. | 10-16-2014 |
20140293225 | DEVICES, SYSTEMS, AND METHODS FOR CALIBRATING AN OCT IMAGING SYSTEM IN A LASER SURGICAL SYSTEM - An adjustment system for an Optical Coherence Tomography (OCT) imaging system includes an OCT light source; a beam splitter, splitting the OCT light beam into an imaging beam to an imaging arm, and a reference beam to a reference arm; a probe, guiding the imaging beam onto a target and receiving a returned imaging beam from the target; the beam splitter generating an interference beam from the returned imaging beam and a returned reference beam from the reference arm; an imaging detector, detecting the interference beam; an imaging processor, generating an OCT image from the detected interference beam; and an adjustment device, removably coupled to the probe, the adjustment device comprising the target attached to a distal region of a target holder at a working distance from a distal end of the imaging probe, wherein an optical length of the reference arm is adjustable to improve a calibration of the OCT image. | 10-02-2014 |
20140288417 | Anamorphic Lens for Rotational Scanning Laser Probe - A surgical probe can include an outer cannula; an inner cannula, rotatably disposed inside the outer cannula; a rotational scanner, disposed at an end of the inner cannula and configured to receive a light beam from a delivery fiber and to scan the light beam along a loop; and an anamorphic optical element, disposed at an end of the outer cannula and configured to receive the light beam scanned along the loop and to output the light beam along an anisotropically compressed loop. A corresponding method can include providing a light beam by a light source; coupling the light beam to a rotational scanner at an end of an inner cannula; scanning the light beam by the rotational scanner along a loop; and receiving the light beam scanned along the loop by an anamorphic optical element and outputting the light beam along an anisotropically compressed loop to a target. | 09-25-2014 |
20140276558 | INFUSION PRESSURE CONTROL USING BLOOD PRESSURE - Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding. | 09-18-2014 |
20140276364 | SYSTEMS AND METHODS FOR OCULAR SURGERY - Ocular surgery may be performed by a variety of systems, processes, and techniques. In certain implementations, systems and processes for ocular surgery may include the ability to emulsify a lens in an eye using a modular hand-held system including a phacoemulsification unit detachably coupled to a pump unit and remove lens portions from the eye using suction provided by the pump unit. The system and the process may also include the ability to decouple the phacoemulsification unit from the pump unit, couple an irrigation-aspiration unit to the pump unit to form a second hand-held system, and remove material from the eye using suction provided by the pump unit. | 09-18-2014 |
20140276343 | ACOUSTIC STREAMING GLAUCOMA DRAINAGE DEVICE - An acoustic streaming valve arrangement induces flow in a glaucoma drainage device. The arrangement may include a selectively vibrating flow generator having a sharp edge and a driving device configured to selectively vibrate the flow generator to create a streaming fluid flow in a direction away from the sharp edge. | 09-18-2014 |
20140271249 | ACOUSTIC PUMPS AND SYSTEMS - A microfluidics acoustic pump system includes a flow passage configured to carry a fluid from one location to another, a selectively vibrating flow generator having a sharp edge, and a driving device configured to vibrate one of the flow generator and the flow passage to create a streaming fluid flow in a direction away from the sharp edge through the flow passage. | 09-18-2014 |
20140263724 | ACOUSTIC STREAMING FLUID EJECTOR - An acoustic streaming fluid ejector includes a fluid filled chamber having an opening, a selectively vibrating flow generator having a sharp edge pointed toward the opening, and a driving device configured to vibrate one of the flow generator and the chamber to create a streaming fluid flow in a direction away from the sharp edge through the opening. Methods are also disclosed. | 09-18-2014 |
20140257315 | SYSTEMS AND PROCESSES FOR INSERTING AN INTRAOCULAR LENS - Various systems and techniques for inserting an intraocular lens are disclosed. In particular implementations, a system and a technique for inserting an intraocular lens may include the ability to move, in response to a force being applied in a first direction along a longitudinal axis, a first plunger tip along the longitudinal axis and into a delivery cartridge to fold an intraocular lens and move in a second direction along the longitudinal axis in response to the applied force being reduced. The system and the technique may also include the ability to engage a second plunger tip and move, in response to a force being applied in the first direction along the longitudinal axis, the second plunger tip along the longitudinal axis and into the delivery cartridge to insert the intraocular lens. | 09-11-2014 |
20140257205 | SYSTEMS AND PROCESSES FOR EYE MOISTURIZING DURING OCULAR SURGERY - Various systems and techniques may be used for moisturizing an eye during ocular surgery. In particular implementations, a system and a technique for moisturizing an eye may include the ability to determine whether an eye should be moisturized during ocular surgery and to activate a fluid control device if an eye should be moisturized. The activation of the fluid control device may allow fluid flow from a fluid reservoir to a fluid nozzle coupled to a nozzle mounting device adapted to hold the fluid nozzle stable relative to a patient's eye. The system and the technique may also include the ability to deactivate the fluid control device. | 09-11-2014 |
20140257172 | ACTIVE ACOUSTIC STREAMING IN HAND PIECE FOR OCCLUSION SURGE MITIGATION - An acoustic streaming arrangement supplements irrigation flow to a surgical site. The acoustic streaming arrangement may include an irrigation conduit configured to carry an irrigation fluid to a surgical site, a selectively vibrating flow generator having a sharp edge, and a driving device configured to selectively vibrate the flow generator to create a streaming fluid flow in a direction away from the sharp edge through the irrigation conduit. Systems and methods are also disclosed. | 09-11-2014 |
20140245619 | Guarded Surgical Knife Handle - A guarded surgical knife handle includes a handle portion with a blade holder, a chamber within the handle portion, and a slot. The guarded surgical knife handle also includes a guard having an open distal end slidably mounted within the handle portion that can slide longitudinally between an unguarded position and a guarded position. The guard is sized to surround the blade in the guarded position. The guarded surgical knife handle also includes a latch that latches the guard when the guard is slid into the guarded position and a first button that disengages the latch. The guarded surgical knife handle includes a bias member that forces the guard in a proximal direction to an unguarded position when the latch is disengaged along with a second button extending through the slot used to slide the guard in a distal direction into the guarded position. | 09-04-2014 |
20140243735 | VITRECTOMY PROBE WITH ADJUSTABLE CUTTER PORT SIZE - Vitrectomy probes and system related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having an adjustable cutting port size. Various example features are described for adjusting the size of the cutting port. Further, the disclosure provides examples for adjusting the size of the cutter port while the vitrectomy probe is in operation. | 08-28-2014 |
20140243731 | INTRAOCULAR PRESSURE SENSOR WITH EXTERNAL PRESSURE COMPENSATION - An intraocular pressure sensor system has a first pressure sensor located in an anterior chamber of an eye and a remote pressure sensor located remotely from the first pressure sensor. The remote pressure sensor measures or approximates atmospheric pressure. A difference between readings from the first pressure sensor and the remote pressure sensor approximates intraocular pressure. | 08-28-2014 |
20140243409 | PHARMACEUTICAL COMPOSITIONS HAVING DESIRABLE BIOAVAILABILITY - The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil. | 08-28-2014 |
20140200566 | MULTI-SPOT LASER PROBE WITH MICRO-STRUCTURED DISTAL SURFACE - An optical surgical probe, configured to optically couple to a light source; comprising a cannula; a light guide within the cannula, configured to receive a light beam from the light source, to guide the light beam to a distal end of the light guide, and to emit the light beam at the distal end of the light guide; and a multi-spot generator at a distal end of the cannula, the multi-spot generator having a faceted proximal surface with oblique facets, configured to receive the light beam emitted at the distal end of the light guide and to split the received light beam into multiple beam-components, and a distal surface through which the multiple beam-components exit the multi-spot generator, wherein the distal surface is micro-structured with a modulation length smaller than a wavelength of the light beam in order to reduce the reflectance of light back into the probe. | 07-17-2014 |
20140194862 | MULTI-SPOT LASER PROBE WITH MICRO-STRUCTURED FACETED PROXIMAL SURFACE - An optical surgical probe includes a cannula; a light guide within the cannula, configured to receive a light beam from the light source, to guide the light beam to a distal end of the light guide, and to emit the light beam at the distal end of the light guide; and a multi-spot generator at a distal end of the cannula, the multi-spot generator having a faceted proximal surface with oblique facets, configured to receive the light beam emitted at the distal end of the light guide and to split the received light beam into multiple beam-components, and a distal surface through which the multiple beam-components exit the multi-spot generator, wherein the proximal surface of the multi-spot generator is micro-structured with a modulation length smaller than a wavelength of the light beam in order to reduce the reflectance of light back into the probe. | 07-10-2014 |
20140194359 | INTERFERING RNA DELIVERY SYSTEM AND USES THEREOF - The invention provides a delivery system comprising a cell penetrating peptide, 10 histidines, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided. | 07-10-2014 |
20140180264 | GRIN FIBER MULTI-SPOT LASER PROBE - A surgical probe includes a cannula assembly, having a graded index (GRIN) fiber that is configured to receive a multi-spot light beam at a proximal end and to emit the multi-spot light beam at a distal end ; an adapter, having a distal end, configured to receive the cannula assembly, with the proximal end of the GRIN fiber, a proximal end, configured to couple to a light guide via a connector and to receive a light delivered by the light guide from a laser source to the adapter, and an interface, configured to couple the light delivered by the light guide to the proximal end of the GRIN fiber; wherein a length of the GRIN fiber is sufficiently long that the interface is outside a patient's eye during a photocoagulation procedure. | 06-26-2014 |
20140178215 | CASSETTE CLAMP MECHANISM - A surgical cassette clamping system includes a mounting plate having a first side and a second side. A bracket system may be disposed adjacent the first side of the mounting plate. A clamp motor may be disposed adjacent the mounting plate and fixed relative to the mounting plate. The clamp motor may be operably connected to the bracket system to displace the bracket system relative to the mounting plate. The system may also include a plurality of pivot arms pivotably connected to the bracket system and extending adjacent the second side of the mounting plate. An engagement portion may be attached to each of the plurality of pivot arms that cooperatively engages the second side of the mounting plate, the engagement portion being operable to pivot the pivot arms when the bracket system moves relative to the mounting plate. | 06-26-2014 |
20140172090 | Osmotically Actuated Fluidic Valve - An implantable fluidic valve actuated by osmotic pressure gradient and methods of operating it are provided. The valve includes: an input fluid channel; an output fluid channel in fluid communication with the input fluid channel at an aperture; and a semi-permeable membrane forming a portion of a sealed chamber. The semi-permeable membrane may have an outer surface forming a wall of the input fluid channel, and an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage. A pump including the above elements and a check valve is provided. An ocular implant including an inlet tube sized to receive aqueous humor and an intra-ocular pressure control system having a fluidic valve as above is also provided. | 06-19-2014 |
20140172010 | FINE MEMBRANE FORCEPS WITH INTEGRAL SCRAPING FEATURE - Membrane forceps for performing an ILM or ERM peel procedure include a handle, a tube extending from the handle, and forceps jaws extending from the tube. The forceps jaws may be configured to grasp an ILM or ERM, and may include an outer surface having a roughened surface. The roughened surface may be structurally configured to aid in gaining an edge of the ILM or ERM. | 06-19-2014 |
20140171996 | Burst Mode Vitrectomy System - A vitrectomy surgical system includes a vitrectomy probe having a cutting portion comprising an inner tube, an outer tube, and an aspiration port. The inner tube may be movable relative to the outer tube to cut vitreous fibers. The system also includes a controller associated with the vitrectomy probe and configured to control movement of the inner tube by generating control signals corresponding to a cutting scheme including a plurality of series of cuts with each cut being evenly spaced in time, the plurality of series of cuts separated by a recovery period. | 06-19-2014 |
20140171995 | Vitrectomy Probe with Integral Valve - A vitrectomy apparatus for performing an ocular surgery may include a vitrectomy probe body graspable by a user and a cutter extending from the body and comprising an inner tube and an outer tube. The inner tube may be moveable relative to the outer tube. The apparatus also may include an actuator within the body and configured to actuate the inner tube relative to the outer tube. A valve may be carried by the body and may be configured to selectively direct a pressurized fluid to the actuator to actuate the inner tube relative to the outer tube. | 06-19-2014 |
20140171959 | Wearable User Interface for Use with Ocular Surgical Console - An ocular surgical system includes a surgical console having a fluidics subsystem, an input pedal subsystem, and a phacoemulsification subsystem. It also includes a wearable user interface in communication with the console. The wearable user interface comprising an interface display having a centrally disposed surgical viewing area and having a peripheral data display region configured to display data relating to the surgery or the console. The peripheral data display region may display information received from the surgical console. | 06-19-2014 |
20140171957 | Control of Automated Intraocular Lens Injectors - A system for implanting an intraocular lens in the lens capsule of an eye to treat an ocular condition includes a housing, a plunger, and an electric motor configured to cause longitudinal translation of the plunger. A cartridge mount may accommodate a removable insertion cartridge so that an intraocular lens disposed in the insertion cartridge is displaced from the insertion cartridge as the plunger is translated. A controller electrically communicates with the electric motor and powers the electric motor to translate the plunger and displace the intraocular lens. The controller may be configured to detect motor current feedback in the control circuit and may be configured to compare the detected motor current feedback to a stored current profile and to stop translation of the plunger when the current level deviates from the stored current profile by a pre-stored amount. | 06-19-2014 |
20140171777 | Systems and Methods for Priming an Intraocular Pressure Sensor in an Intraocular Implant - An IOP monitoring device for implantation in an eye of a patient may include a first tube having a first opening, the first tube being configured to extend into the anterior chamber. An intraocular pressure sensing (IOP) device for implantation in an eye of a patient may include a pressure sensor, a pressure sensor cap, and a tube coupled to a chamber inlet. The pressure sensor cap may include a recess having an inner surface, the recess configured to receive the pressure sensor such that a chamber is formed by the pressure sensor and the inner surface and a chamber inlet permitting a fluid to communicate with the chamber and be primed in a bubble-free manner. The tube may be coupled to the chamber inlet to allow fluid communication between an anterior chamber of the eye and the chamber. | 06-19-2014 |
20140171487 | RNAi-MEDIATED INHIBITION OF PHOSPHODIESTERASE TYPE 4 FOR TREATMENT OF cAMP-RELATED OCULAR DISORDERS - RNA interference is provided for inhibition of phosphodiesterase type 4 mRNA expression for treating patients with a cAMP-related ocular disorder. Phosphodiesterase type 4 mRNA targets include mRNA for 4A, 4B, 4C, and 4D phosphodiesterase isoforms. | 06-19-2014 |
20140166140 | MEMS Check Valve - A MEMS check valve includes a supporting portion having a first perforation therethrough sized to permit fluid flow and includes a displaceable portion having a second perforation therethrough sized to permit fluid flow. The displaceable portion may be moveable relative to the supporting portion between a closed position inhibiting fluid flow through the valve and an open position permitting fluid flow through the valve. The first and second perforations are offset to inhibit fluid flow when the displaceable portion is in the first position, and fluid may flow through the first and second perforations when the displaceable portion is in the second position. | 06-19-2014 |
20140163542 | SYSTEM AND PROCEDURE FOR ENHANCING OCULAR DRAINAGE - Various systems, apparatuses, and processes may be used for enhancing ocular drainage. In particular implementations, a system for ocular drainage may include an ocular interface that includes a base and a number of diathermy needles. The diathermy needles may extend from the base a distance sufficient to penetrate a sclera of an eye and provide radio frequency energy to a trabecular meshwork. | 06-12-2014 |
20140163455 | PHACOEMULSIFICATION HAND PIECE WITH INTEGRATED ASPIRATION AND IRRIGATION PUMP - A method of irrigating a surgical site and aspirating fluid from the surgical site. The method includes directing a fluid through an aspiration conduit in a phacoemulsification hand piece using a vacuum pressure created from a pump in the hand piece interfacing with the aspiration conduit and directing an irrigation fluid through an irrigation conduit in the hand piece using a pressure created from the pump interfacing with the irrigation conduit. The method also includes increasing an irrigation fluid flow through the irrigation conduit by activating the pump in the hand piece, detecting a pressure associated with a surgical site using a sensor, and controlling intraocular pressure (IOP) by adjusting the pump speed based on the detected pressure. | 06-12-2014 |
20140163454 | VACUUM CONTROL METHOD FOR SURGICAL HAND PIECE - A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow. | 06-12-2014 |
20140163448 | SUPRACHORIODAL DRAINAGE TUBE IN A FLOW CONTROL SYSTEM - Described herein is a treatment device for the drainage of fluid within an eye of a patient. The treatment device comprises a drainage tube and a flow system in fluid communication with the drainage tube. The drainage tube has a lumen and comprises an inlet tube portion and an outlet tube portion, and is configured to convey aqueous humor through the lumen from an anterior chamber of the eye to a suprachoroidal space of the eye. The inlet tube portion extends from the anterior chamber to the flow system, and the outlet tube portion is flexible to conform to the curvature of the suprachoroidal space and extends from the valve system to the suprachoroidal space. The flow system is configured to control intraocular pressure by throttling flow rates of the aqueous humor through the drainage tube. | 06-12-2014 |
20140162990 | FINAFLOXACIN SUSPENSION COMPOSITIONS - The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a suspension composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin free base or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections. | 06-12-2014 |
20140161760 | POLYMERIC ARTIFICIAL TEAR SYSTEM - The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations. | 06-12-2014 |
20140155817 | INFUSION PRESSURE CONTROL USING BLOOD PRESSURE - Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding. | 06-05-2014 |
20140135820 | DISPOSABLE CAPSULORHEXIS FORCEPS - Example forceps, including forceps formed from a polymeric material, are disclosed herein. The forceps may include a forceps tip having a pair of grasping surfaces formed at a first end of a tip body and movable between an open position and a closed position. A tip connector is provided at a second end of the tip body for connection of the forceps tip to a handle. A sleeve is received over the tip body and is movable therealong for moving the grasping platforms between the open and closed positions. | 05-15-2014 |
20140135267 | INTERFERING RNA DELIVERY SYSTEM AND USES THEREOF - The invention provides a delivery system comprising a cell penetrating peptide, a polyarginine peptide, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided. | 05-15-2014 |
20140128847 | OCULAR INFUSION SYSTEM - Systems, processes, and articles of manufacture may be used to perform ocular infusion. In particular implementations, a system for ocular infusion may include a length of flexible tubing and a tip adapted to be inserted into an eye. The flexible tubing may be adapted to convey an ocular infusion fluid and include a plurality of coils set in at least a portion thereof. The ocular tip may be coupled to a first end of the flexible tubing and adapted to convey ocular infusion fluid from the flexible tubing into an eye. | 05-08-2014 |
20140128478 | PUNCTAL PLUG COMPRISING A WATER-INSOLUBLE POLYMERIC MATRIX - Disclosed is a pharmaceutical composition comprising a water insoluble polymer matrix that comprises a bioerodable polyester polymer or a fatty acid based polyester polymer, or a mixture of both polymers, wherein the polymer matrix has a melting point of less than 60° C., and wherein the composition is liquid or paste at room temperature and is formulated to occlude a punctual channel in a subject and conforms to the shape of the canalicular or punctal channel. | 05-08-2014 |
20140124476 | SURGICAL PROBE - An exemplary surgical probe and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a scissor assembly received at least partially within the body. The scissor assembly may include a first blade fixed to the tubular body that includes a body portion and an end portion. The scissor assembly may further include a second blade that is configured to move longitudinally within the tubular body. The body portions of the first and second blades may each define respective cross sections normal to a longitudinal axis of the tubular body. The cross sections may each define centrally disposed edges adjacent one another, and the cross sections may each be asymmetrical about a line substantially parallel to the centrally disposed edges. | 05-08-2014 |
20140121469 | ILLUMINATED VITRECTOMY CUTTER WITH ADJUSTABLE ILLUMINATION APERTURE - A vitrector that includes an adjustable illumination aperture is described. The vitrector may include a probe and a light sleeve assembly extending along and substantially surrounding the probe. The light sleeve assembly may include a plurality of optical fibers. At least a portion of the optical fibers are operable to provide illumination so as to define an illumination aperture about the vitrectomy probe. A portion of the optical fibers may be encapsulated. The light sleeve assembly may be adjustable along a length of the probe, providing adjustment of the illumination aperture to increase or decrease an area of illumination provided thereby. | 05-01-2014 |
20140114237 | Pressure Control in Phacoemulsification System - A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor. | 04-24-2014 |
20140114236 | Pressure Control in Phacoemulsification System - A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor. | 04-24-2014 |
20140107557 | CAPILLARY ACTION IN FLOW-REGULATING SYSTEMS - A fluid flow-regulating system includes an electrolysis chamber configured to contain a liquid, and includes first and second electrodes disposed within the electrolysis chamber. A gap between opposing surfaces is sized to promote capillary action of a liquid in the electrolysis chamber that draws the liquid to at least one of the first and second electrodes in a manner allowing the flow-regulating system to be placed in multiple orientations and still have said one of the first and second electrodes wetted by capillary action. | 04-17-2014 |
20140107459 | DEVICES, SYSTEMS, AND METHODS FOR INTRAOCULAR MEASUREMENTS - An implantable sensor assembly sized for insertion within an eye of an average human is disclosed. The sensor assembly comprises a sensor and an antenna system coupled to the sensor, wherein the antenna system is pliable between an expanded condition and an unexpanded condition, and the expanded condition has a predetermined shape configured to interface with tissue within the eye in a manner that stabilizes the sensor assembly. | 04-17-2014 |
20140107121 | OLOPATADINE COMPOSITIONS AND USES THEREOF - The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula I: | 04-17-2014 |
20140100518 | SYSTEMS AND METHODS FOR EXTERNAL PRESSURE SENSING - In various embodiments, a device for delivering pressurized irrigation may include a squeeze plate and a pressure sensor module. The squeeze plate may move relative to the pressure sensor module to apply pressure to a flexible container (e.g., a bag of irrigation fluid) between the squeeze plate and the pressure sensor module. The pressure sensor module may include a pressure sensor to measure a force exerted on the pressure sensor module by the flexible container as pressure is applied to the flexible container from the squeeze plate. In some embodiments, the pressure sensor module may include a bag contact plate and the pressure sensor may measure a force exerted on the bag contact plate by the flexible container located between the bag contact plate and the squeeze plate. In some embodiments, the pressure sensor may sense a pressure associated with the flexible container without an intervening bag contact plate. | 04-10-2014 |
20140094736 | Valve Position Sensor - An IOP control device for implantation in an eye of a patient is disclosed, including a housing with an entrance port and an exit port, a membrane anchored within the housing in a manner forming a flow control chamber on a first side of the membrane and a fluid flow passageway on a second opposing side of the membrane, and a position sensor system. The flow control chamber is arranged to contain a gas creating a flow control chamber pressure, and the membrane is configured to affect flow through the fluid flow passageway from the entrance port to the exit port by deflecting in response to changes in the flow control chamber pressure. The position sensor system includes a first conductive portion and a second conductive portion positioned to selectively contact the first conductive portion to indicate the position of the membrane relative to the fluid flow passageway. | 04-03-2014 |
20140094419 | INJECTABLE AQUEOUS OPHTHALMIC COMPOSITION AND METHOD OF USE THEREFOR - The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent. | 04-03-2014 |
20140088172 | RNAi-Mediated Inhibition of Histamine Receptor H1-Related Conditions - RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy. | 03-27-2014 |
20140081224 | ASPIRATION CASSETTE WITH GAS AND DEBRIS MANAGEMENT - Embodiments of this disclosure provide an apparatus and method for gas and debris management. The apparatus comprises a surgical cassette, wherein the surgical cassette is at least partially formed of a cassette material defining a chamber. The surgical cassette has a floor and a plurality of walls. The apparatus also has a drain conduit with a drain entry and a drain exit. The drain entry is connected to the chamber near the floor. The drain conduit has a top portion and a bottom portion. The apparatus also has an aspiration conduit. The aspiration conduit has an aspiration port and an aspiration exit. The aspiration conduit is in liquid communication with the chamber and the drain conduit. At least a portion of the top portion of the drain conduit is positioned above at least a portion of the aspiration exit. | 03-20-2014 |
20140080793 | PHARMACEUTICAL COMPOSITIONS WITH PHOSPHONIUM ANTIMICROBIAL AGENTS - The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP). | 03-20-2014 |
20140074017 | SYSTEM AND METHOD OF PRIMING A SURGICAL CASSETTE - The present disclosure relates in general to an apparatus and method for priming a liquid or surgical cassette. In one embodiment, an infusion system within the liquid cassette is primed using a forward flow of a liquid and a backward flow of the liquid. The forward flow of the liquid creates a first volume of liquid stored within an infusion conduit, which is connected to an infusion chamber via a first valve. The infusion conduit has an infusion port exposed to a non-liquid environment having a first pressure. A second pressure is created in the infusion chamber that is lower than the first pressure. Opening the first valve causes a second volume of liquid within the infusion conduit to flow over the first valve and towards the infusion chamber. The second volume of liquid is less than or equal to the first volume of liquid. | 03-13-2014 |
20140074011 | SYSTEMS AND METHODS FOR REINJECTION OF PROCESSED VITREOUS HUMOR - A system for the removal of vitreous humor and other fluids from an eye and the reinjection of filtered vitreous humor into the eye is provided. The system comprises a hollow removal device, a filter, and an infusion device. The removal device includes an element configured to cut the vitreous humor and is configured to aspirate the vitreous humor from the eye. The filter is configured to create a filtered form of vitreous humor by separating the vitreous humor from undesired components in the vitreous humor. The infusion device is fluidly coupled to the filter and is configured to return the filtered form of vitreous humor into the eye. | 03-13-2014 |
20140066723 | White coherent laser light launched into nano fibers for surgical illumination - Disclosed is an exemplary surgical illumination system that includes a first laser configured to emit a first light beam having a first spectral range, and an illumination probe optically connectable to the first laser. The first laser may be configured as a supercontinuum laser. The surgical illumination system may include a second laser configured to emit a second light beam having a second spectral range, and a beam combiner for combing the first and second laser beams to form a third laser beam having a spectral range of the first and second lasers. The illumination probe includes a fiber optic cable for delivering at least a portion of the first light beam to a surgical site. The fiber optic cable includes a fiber optic core having a diameter of 100 microns or less. | 03-06-2014 |
20140063492 | PRODUCTION PROCESS FOR AN INTERFACE UNIT AND A GROUP OF SUCH INTERFACE UNITS - A process for producing an interface unit and also a group of such interface units are specified. The interface unit exhibits a first reference surface for beaming in radiation, a second reference surface for emitting the radiation, and an axis extending in the direction from the first to the second reference surface. The production process comprises the steps of setting an optical path length of the interface unit between the first and second reference surfaces along the axis and the fixing of the set optical path length of the interface unit. The optical path length of the interface unit is set in such a way that radiation of a defined numerical aperture beamed in at the first reference surface exhibits a focus location that is predetermined with respect to the second reference surface in the direction of the axis. A precise and uniform focus location with respect to the second reference surface is obtained. | 03-06-2014 |
20140052141 | PHACOEMULSIFICATION HOOK TIP - In various embodiments, a phacoemulsification cutting tip with a straight shaft and an angled portion off of the straight shaft may include a hook on the angled portion to move an axis of rotation of the cutting tip closer to alignment with an extended centerline of the shaft. The cutting tip may be configured to torsionally rotate back and forth on an axis perpendicular to a centerline of the shaft (e.g., rotation around a y-axis). In some embodiments, lateral vibrations (e.g., side to side along an x-axis or z-axis perpendicular to the y-axis) that result from torsional rotation around the y-axis in a cutting tip without the hook may be reduced through use of the hook to balance the otherwise eccentrically weighted hook. | 02-20-2014 |
20140052053 | Infusion Sleeve with Motion Reduction Profile - An infusion sleeve has a flexible tube enclosing a lumen. The tube has a plurality of wall segments, each wall segment located between the lumen and an exterior surface of the tube and extending parallel to a central axis of the tube. The plurality of wall segments includes at least two thick wall segments and at least two thin wall segments alternately arranged such that each thick wall segment is adjacent to two thin wall segments, and each thin wall segment is adjacent to two thick wall segments. | 02-20-2014 |
20140031414 | SIRNA TARGETING VEGFA AND METHODS FOR TREATMENT IN VIVO - Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression. | 01-30-2014 |
20140018296 | LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY - The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided. | 01-16-2014 |
20130345394 | NOVEL NPR-B AGONISTS - Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. | 12-26-2013 |
20130345136 | NOVEL NPR-B AGONISTS - Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. | 12-26-2013 |
20130338564 | GLAUCOMA DRAINAGE DEVICES INCLUDING VARIO-STABLE VALVES AND ASSOCIATED SYSTEMS AND METHODS - Glaucoma drainage devices including vario-stable valves and associated systems and methods are disclosed. A glaucoma drainage device includes a drainage lumen and a valve system coupled to the drainage lumen to control the flow of fluid through the drainage lumen. The valve system includes an adjustable valve with a diaphragm that is in communication with the drainage lumen and is movable to occupy varying amounts of the drainage lumen. In some embodiments, the valve system is maintained in a desired position without the use of power such that power is only needed when changing a position of the adjustable valve. | 12-19-2013 |
20130338213 | RNAi-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR ALPHA-RELATED CONDITIONS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example. | 12-19-2013 |
20130335707 | ADAPTIVE VISUAL PERFORMANCE TESTING SYSTEM - A method of testing visual performance includes determining a difficulty rating for each of a plurality of visual recognition tests. The method further includes displaying one of the visual recognition tests to a subject and receiving from the subject a response to the visual recognition test. After receiving the response to the visual recognition test, a subsequent visual recognition test is selected to have a difficulty rating determined based on the response received from the subject, the subsequent visual recognition test is displayed, and a response is received from the subject. The subsequent visual recognition tests are repeated until a predetermined number of responses is reached. A visual performance score is determined based on the set of responses received from the subject and the difficulty ratings for the visual recognition tests displayed to the subject is then output. | 12-19-2013 |
20130331385 | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC, OTIC, OR NASAL INFECTIONS - The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections. | 12-12-2013 |
20130330430 | PROCESS FOR PURIFYING GUAR - The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described. | 12-12-2013 |
20130317514 | INTRAOCULAR LENS DELIVERY DEVICE WITH A MULTI-PART PLUNGER TIP - The present invention is directed to the provision of an intraocular lens delivery device having a plunger with a multi-part plunger tip. The plunger tip includes a first part and a second part wherein the first part releases from the second part during travel of the plunger through the body of a delivery cartridge. | 11-28-2013 |
20130296264 | OPHTHALMIC COMPOSITIONS WITH IMPROVED DESSICATION PROTECTION AND RETENTION - The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound. | 11-07-2013 |
20130274216 | TREATMENT FOR MICROBE-INDUCED INFLAMMATORY RESPONSES IN THE EYE - The present invention relates to ophthalmic compositions comprising inhibitors of spleen tyrosine kinase (syk). The compositions are particularly well suited for the treatment of ophthalmic infection such as fungal keratitis. The compositions optionally comprise an antiinfective compound such as an antibacterial or antifungal compound. The present invention also relates to methods for treating fungal keratitis using compositions comprising syk inhibitors. | 10-17-2013 |
20130261649 | SURGICAL PROBE - An exemplary surgical probe and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a scissor assembly received at least partially within the body. The scissor assembly may include a first blade fixed to the tubular body that includes a body portion and an end portion. The scissor assembly may further include a second blade that is configured to move longitudinally within the tubular body. The body portions of the first and second blades may each define respective cross sections normal to a longitudinal axis of the tubular body. The cross sections may each define centrally disposed edges adjacent one another, and the cross sections may each be asymmetrical about a line substantially parallel to the centrally disposed edges. | 10-03-2013 |
20130245098 | RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions. | 09-19-2013 |
20130244971 | STABILIZED OPHTHALMIC GALACTOMANNAN FORMULATIONS - The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride. | 09-19-2013 |
20130218064 | Glaucoma Drainage Device with Pump - A glaucoma drainage device has a main drainage tube with a first end an anterior chamber of an eye and a second end in a drainage location. A bypass drainage tube is fluidly coupled to and in parallel with the main drainage tube. A pump is in communication with the bypass drainage tube. The pump comprises a first driver and a first flexible membrane enclosing a first chamber. A first check valve is located upstream from the pump, and a second check valve is located downstream from the pump. An active valve is located upstream from the first check valve. The active valve comprises a second driver and a second flexible membrane enclosing a second chamber. A third check valve is located between the active valve and the second end of the main drainage tube. A volume of the first chamber is changed to pump fluid from the anterior chamber. | 08-22-2013 |
20130210812 | Aqueous Pharmaceutical Composition With Enhanced Stability - The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition. | 08-15-2013 |
20130204177 | Active Drainage Systems with Dual-Input Pressure-Driven Values - A pressure-driven valve is disclosed. The valve includes a housing, a fluid flow channel, and a deflectable portion. The housing comprises a fluid inlet and a fluid outlet. The fluid flow channel extends between the fluid inlet and the fluid outlet. The deflectable portion is disposed within the housing, and defines a portion of the fluid flow channel. The deflectable portion is configured to deflect to increase and decrease a size of the fluid flow channel to regulate fluid flow from the fluid inlet to the fluid outlet. The deflectable portion is disposed and arranged to deflect as a result of pressure differentials between a reference pressure, a fluid flow channel pressure, and an outlet pressure representative of fluid pressure at the fluid outlet. | 08-08-2013 |
20130178421 | INTERFERING RNA DELIVERY SYSTEM AND USES THEREOF - The invention provides a delivery system comprising a cell penetrating peptide, 10 histidines, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided. | 07-11-2013 |
20130177580 | TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY - The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided. | 07-11-2013 |
20130169412 | Haptic Footswitch Treadle - A haptic footswitch treadle for use in microsurgical systems is disclosed. The haptic footswitch treadle includes a haptic surface coupled to a pivotable treadle base and configured to convey vibratory haptic feedback to a surgeon. The haptic footswitch includes a positional sensor coupled to the treadle base and suspension elements and actuators positioned between the haptic surface and the treadle base. The actuators are configured to move the suspension elements and the haptic surface based on command signals generated by haptic software applications in response to data from the positional sensor. | 07-04-2013 |
20130165850 | COMBINED COAXIAL AND BIMANUAL IRRIGATION/ASPIRATION APPARATUS - A hand piece having an irrigation portion and an aspiration portion that are releasably coupled is disclosed. In an assembled configuration, the irrigation portion and the aspiration portion are coupled such that the hand piece may be manipulable by a user as a single unit. In a separated configuration, the irrigation portion and the aspiration portion may be utilized separate from each other. The irrigation portion and the aspiration portion may be freely moved between the assembled configuration and the separated configuration. | 06-27-2013 |
20130150839 | Devices and Methods for Reconfigurable Multispot Scanning - An ophthalmic laser probe system comprises an array of optical waveguides and an adapter operable to connect with a laser source. The laser probe system further includes a first reflective surface within the adapter. The first reflective surface is movable about a first axis. The laser probe system also includes a second reflective surface within the adapter. The second reflective surface is movable about a second axis orthogonal to the first axis. The first reflective surface is configured to receive a laser beam emitted from the laser source and redirect the laser beam toward the second reflective surface. | 06-13-2013 |
20130150782 | Selectively Moveable Valve Elements for Aspiration and Irrigation Circuits - Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve. | 06-13-2013 |
20130150779 | Active Drainage Systems with Dual-Input Pressure-Driven Valves - A pressure-driven valve is disclosed. The valve includes a housing and a flow control portion disposed within the housing. The housing includes a fluid inlet and a fluid outlet. The flow control portion has a first side subject to fluid flow pressure in a fluid flow channel, and a second side subject to an outlet pressure representative of pressure at the fluid outlet. The flow control portion is deformable to increase and decrease flow through the fluid flow channel based on pressure differentials between the fluid flow pressure, a tube pressure, and the outlet pressure. In some instances, the flow control portion comprises a flow control membrane and a radially-fluctuating pressure tube attached to the periphery of the membrane. | 06-13-2013 |
20130150778 | Separation of Gas and Liquid in Membrane Valves - A drainage device for implantation in an eye of a patient to treat an ocular condition is disclosed. The drainage device includes a housing, a multi-compartment flow control chamber, and a membrane. The housing includes an entrance port and an exit port connected by a fluid flow passageway. The membrane is disposed between the fluid flow passageway and the multi-compartment flow control chamber, which includes a first compartment and a second compartment in fluid communication with each other. The first and second compartments are structurally arranged to limit contact of gas with the membrane, which is disposed between the fluid flow passageway and first compartment. The membrane is configured to affect flow through the fluid flow passageway by deflecting in response to pressure in the flow control chamber. | 06-13-2013 |
20130142837 | CELLULOSIC GEL COMPOSITION WITH IMPROVED VISCOSITY STABILITY - The present invention is directed to cellulosic gel compositions having improved viscosity stability through the exclusion of particular antioxidants and/or the exclusion of chemical entities that tend to produce free radicals. Preferably, the composition is an ophthalmic cellulosic gel composition that is suitable as a multi-dose composition. | 06-06-2013 |
20130137741 | Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye - The present invention relates to development of efficacious pharmaceutical compositions in the form of aqueous solutions comprising an active agent in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000. | 05-30-2013 |
20130116219 | ANTIMICROBIAL CARBOLINE COMPOUNDS - The invention provides compositions comprising carboline compounds for treating infections such as viral conjunctivitis. The invention also provides methods for treating of other infections, including ocular infections. More particularly, the present invention relates to compositions comprising carboline compounds for the treatment of ocular infections such as viral conjunctivitis, particularly those caused by adenovirus | 05-09-2013 |
20130053440 | Self-Preserved Aqueous Pharmaceutical Compositions - The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borate or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred. Limiting the amount of divalent metals other than zinc and the amount of ionized salts present has also been determined to be important to maximize the antimicrobial activity of the balanced buffer systems. | 02-28-2013 |
20120315288 | LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY - The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided. | 12-13-2012 |
20120283260 | BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA - The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists. | 11-08-2012 |
20120264809 | RNAi-Mediated Inhibition of Histamine Receptor H1-Related Conditions - RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy. | 10-18-2012 |
20120245217 | RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions. | 09-27-2012 |
20120178794 | RNAi-Mediated Inhibition of RHO Kinase for Treatment of Ocular Disorders - RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2. | 07-12-2012 |
20120172786 | MULTI-SLEEVED SURGICAL ULTRASONIC VIBRATING TOOL SUITED FOR PHACOEMULSIFICATION IN A MANNER THAT PREVENTS THERMAL INJURY TO OCULAR TISSUE - A multi-sleeve handpiece for performing phacoemulsification with a vibratory, ported needle and for cooling an exterior of an incision. The vibratory, ported needle breaks up and aspirates broken eye tissue. The handpiece has at least one inner sleeve that guides irrigation fluid to the eye and/or reduces friction between the vibrating tool and the surrounding rigid sleeve or tissues. The handpiece has an outer, cooling sleeve that is concentric with the inner sleeve and the needle and whose distal end has peak and valley formations. The cooling sleeve is collapsible to engage incision tissue with the peak formations and allow the cooling fluid to flow across the valley formations to cool the tissue via heat transfer. | 07-05-2012 |
20120143125 | Combined Coaxial and Bimanual Irrigation/Aspiration Apparatus - In one exemplary aspect, the present disclosure is directed to an assembly having an irrigation hand piece that includes an irrigation needle extending from a distal end. The irrigation needle is also configured to release a first fluid. The assembly further has an aspiration hand piece that includes an aspiration needle extending from a distal end. The aspiration needle has an axis and is configured to aspirate a second fluid into the assembly. The assembly has a first configuration in which the irrigation hand piece and aspiration hand piece are coupled together in a manner that causes the released first fluid from the assembly to flow coaxially about the axis of the aspiration needle and a second configuration in which the irrigation hand piece and aspiration hand piece are uncoupled which causes the released first fluid to flow substantially non-coaxial with respect to the axis of the aspiration needle. | 06-07-2012 |
20120142630 | PROCESS FOR PURIFYING GUAR - The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described. | 06-07-2012 |
20120116216 | Low Viscosity, Highly Flocculated Triamcinolone Acetonide Suspensions for Intravitreal Injection - Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection. | 05-10-2012 |
20120115870 | CONTROL OF INTRAOCULAR PRESSURE USING ALK5 MODULATION AGENTS - An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient. | 05-10-2012 |
20120115829 | Low Viscosity, Highly Flocculated Triamcinolone Acetonide Suspensions for Intravitreal Injection - Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection. | 05-10-2012 |
20120108632 | PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA - The invention concerns in one embodiment a method of treating glaucoma or elevated intraocular pressure comprising administering a pharmaceutically effective amount of a composition comprising at least one prenyltransferase inhibitor. In another embodiment, the invention concerns a composition for the treatment of elevated intraocular pressure and glaucoma comprising a pharmaceutically effective amount of a prenyltransferase inhibitor. | 05-03-2012 |
20120108557 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS - The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity. | 05-03-2012 |
20120077864 | RNAI-MEDIATED INHIBITION OF GREMLIN FOR TREATMENT OF IOP-RELATED CONDITIONS - RNA interference is provided for inhibition of gremlin in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma. | 03-29-2012 |
20120070402 | POLYMERIC ARTIFICIAL TEAR SYSTEM - The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations. | 03-22-2012 |
20120065187 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE - The present invention relates to compounds and methods which may be useful as inhibitors of H | 03-15-2012 |
20120046285 | BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA - The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists. | 02-23-2012 |
20120038222 | Self-Matching Pulse Generator with Adjustable Pulse Width and Pulse Frequency - Pulse-generator circuits that permit independent control of pulse widths and the delays between successive pulses. In several embodiments, a pulse-generator subcircuit includes a transmission-line segment comprising first and second conductors, configured such that the first conductor is coupled to a first DC potential. The pulse-generator subcircuit further includes a terminating resistor coupled to a first end of the second conductor of the first transmission-line segment; this terminating resistor is matched to the characteristic impedance of the transmission-line segment. The pulse-generator subcircuit further includes first and second switches, controlled by first and second timing signals, respectively, and configured to selectively and independently connect respective first and second ends of the first conductor to a second DC potential. This second potential may be ground, in some embodiments, while the DC potential supplied to the pulse-generator subcircuit by the power-supply subcircuit may range from a very small voltage to voltages exceeding a kilovolt. | 02-16-2012 |
20120029051 | siRNA Targeting VEGFA and Methods for Treatment In Vivo - Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression. | 02-02-2012 |
20120004528 | Implantable Remote Monitoring Sensor - An exemplary implantable sensor includes a housing that generally conforms to a curvature of an anterior chamber of a patient's eye. A sensing device disposed in the housing is configured to detect physiological parameters and transmit a signal representing the physiological parameters. The exemplary sensor may be used to detect physiological parameters such as intraocular pressure, flow velocity of aqueous humor, blood sugar, and blood biochemicals. | 01-05-2012 |
20120004245 | COMPOUNDS FOR THE TREATMENT OF POSTERIOR SEGMENT DISORDERS AND DISEASES - The use of certain urea compounds, for the treatment of retinal disorders associated with pathologic ocular angiogenesis and/or neovascularization is disclosed. | 01-05-2012 |
20110319810 | Curved Infusion Sleeve - An infusion sleeve, infusion sleeve assembly, and method of making the same are disclosed. An exemplary infusion sleeve assembly may include a tubular body and a tip inserted into the body. The tubular body may include an insertion end and an attachment end. The insertion end may define a tip aperture and a first fluid aperture adjacent the tip aperture, while the attachment end may be configured to be secured to a surgical tool for fluid exchange therewith. The tubular body includes a curved portion between the insertion end and attachment end such that a first axis of the insertion end is angled relative to a second axis of the attachment end. Further, the tubular body may define a substantially smooth surface throughout the curved portion. | 12-29-2011 |
20110313343 | Phacoemulsification Fluidics System Having a Single Pump Head - A phacoemulsification fluidics system for irrigating and aspirating a surgical site includes a sterile solution reservoir, an irrigation path configured to extend from the sterile solution reservoir to the surgical site, and an aspiration path configured to extend from the surgical site. The system also includes a single flow control pump head associated with both the irrigation path and the aspiration path. The flow control pump head is arranged within the system to simultaneously pressurize the irrigation path in a manner that drives the irrigation fluid to the surgical site and pressurize the aspiration path in a manner that vacuums waste fluid from the surgical site. | 12-22-2011 |
20110301425 | Inductive Task Light For Surgical Console - A task light system for a surgical console includes a task light that can be held to a coupling location on a surgical console. The task light has an inductive coupling, a light source, and a goose neck connecting the light source to the inductive coupling. The coupling location is located on a face of the surgical console. The coupling location is configured to magnetically attract and hold the inductive coupling. The face of the surgical console where the coupling location is located is a continuous surface. | 12-08-2011 |
20110300019 | USE OF PBO-PEO-PBO BLOCK COPOLYMERS IN OPHTHALMIC COMPOSITIONS - The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful, for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention. | 12-08-2011 |
20110295191 | Infusion Pressure Monitoring System - An infusion pressure monitoring system for a phacoemulsification or vitrectomy machine to be operated by a health care provider includes an irrigation path configured to carry an irrigation solution to a surgical site and a fluid sensor configured to detect a fluid parameter in the irrigation path. An input device receives a variable fluid flow command from the health care provider commanding an irrigation fluid flow through the irrigation path at a flow rate corresponding to the command. A controller communicates with both the fluid sensor and the input device. The controller determines an expected fluid pressure value and a dynamically variable threshold pressure value based upon the variable fluid flow command. | 12-01-2011 |
20110288157 | RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions - RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease. | 11-24-2011 |
20110288101 | SURGICAL COMPOSITIONS CONTAINING SIGMA-RECEPTOR AGONISTS - One aspect of the present invention relates to aqueous surgical compositions comprising a sigma-1 receptor agonist. Another aspect of the present invention relates to methods of irrigating ocular tissues during an ophthalmic surgical procedure such as cataract surgery. Such methods comprise bathing the ocular tissues with a composition comprising a sigma-1 receptor agonist. | 11-24-2011 |
20110275593 | STABILIZED OPHTHALMIC GALACTOMANNAN FORMULATIONS - The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride. | 11-10-2011 |
20110274322 | DEVICES AND METHODS FOR ASSESSING CHANGES IN CORNEAL HEALTH - A computer-implemented method for use in assessing a cornea which includes selecting a principal image from among a series of layered images of the cornea. The computer-implemented method further includes detecting a plurality of corneal structures in the principal image and providing a quantitative analysis of the plurality of corneal structures. | 11-10-2011 |
20110269822 | RNAi-Mediated Inhibition of Histamine Receptor H1-Related Conditions - RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy. | 11-03-2011 |
20110257658 | Modular Intraocular Lens Injector Device - An intraocular lens (IOL) injection device is modularized to enable cleaning of internal components after surgery. The device includes first and second housing modules. These modules collectively define a passageway along which an injector rod moves between a retracted position and an extended position. The first module is further configured to accommodate a lens cartridge module. The cartridge module has disposed therein an IOL, in alignment with the passageway. Thus as the rod moves from the retracted position to the extended position, a front portion of the rod that is substantially surrounded by the first module in the retracted position moves into the cartridge module and displaces the IOL. This causes the front portion of the rod to accumulate on it viscoelastic substances. The first module, though, is configured to detach from the second module, to thereby expose the front portion of the rod in the retracted position for cleaning. | 10-20-2011 |
20110257248 | RNAi-RELATED INHIBITION OF TNFa SIGNALING PATHWAY FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy. | 10-20-2011 |
20110257246 | RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions. | 10-20-2011 |
20110256156 | TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY - The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided. | 10-20-2011 |
20110248671 | Power System Implantable in Eye - An implantable ophthalmic power system includes a power source and an enclosure. The enclosure surrounds the power source. The enclosure is configured to be implanted under the conjunctiva of the eye. | 10-13-2011 |
20110245319 | RNAi-Mediated Inhibition of RHO Kinase for Treatment of Ocular Disorders - RNA interference is provided for inhibition of Rho kinase mRNA expression for treating patients with ocular disorders, particularly for treating intraocular pressure, ocular hypertension and glaucoma. Rho kinase mRNA targets include mRNA for ROCK1 and ROCK2. | 10-06-2011 |
20110230877 | Pulsed Electric Field Probe for Glaucoma Surgery - A small gauge pulsed electric field/aspirator probe. The probe has a generally cylindrical cannula with a generally smooth distal end. A port is located near a distal end of the cannula on a side of the cannula. A pair of electrodes is located at the port. An electric pulse generator is coupled to the pair of electrodes. A distance between the distal end of the cannula and the port is approximately equal to the distance between a back wall of Schlemm's canal and a trabecular meshwork in a human eye. The electric pulse generator applies a pulsed electric field to the pair of electrodes sufficient to dissociate protein bonds that hold the trabecular meshwork together. | 09-22-2011 |
20110230410 | LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY - The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided. | 09-22-2011 |
20110207809 | METHOD OF ACCELERATING CORNEAL WOUND HEALING - The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed. | 08-25-2011 |
20110202049 | Small Gauge Ablation Probe For Glaucoma Surgery - An ablation probe for use in glaucoma surgery has a shaft, a heating element, and a pair of electrical connectors located on a distal end of the shaft. The pair of electrical connectors holds the heating element to the shaft. The heating element is sized and shaped to ablate a trabecular meshwork in a human eye. The ablation probe is advanced through a corneal incision until the heating element contacts the trabecular meshwork. An electrical current is passed through the heating element to ablate the trabecular meshwork. | 08-18-2011 |
20110195962 | USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS - Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or more pro-inflammatory cytokines (for instance IL-1 and TNFα) and inhibit p | 08-11-2011 |
20110195132 | Self-Preserved Aqueous Pharmaceutical Compositions - The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borate or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred. Limiting the amount of divalent metals other than zinc and the amount of ionized salts present has also been determined to be important to maximize the antimicrobial activity of the balanced buffer systems. | 08-11-2011 |
20110190376 | RNAi-RELATED INHIBITION OF TNFa SIGNALING PATHWAY FOR TREATMENT OF MACULAR EDEMA - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having or at risk of developing macular edema. | 08-04-2011 |
20110164218 | METHOD AND APPARATUS FOR OCULAR SURFACE IMAGING - The invention provides apparatuses and methods for detecting ocular surface defects. The methods and/or an apparatus of the invention can be used to detect ocular surface diseases, such as dry eye, uveitis, conjunctivitis, keratitis, keratoconjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), autoimmune disorders of the ocular surface, meibomianitis, conjunctival hyperemia, eyelid hyperemia, ocular rosacea, ocular inflammation, or eye lid swelling. | 07-07-2011 |
20110160308 | Use of Monoamine Oxidase Inhibitors to Treat Outer Retina Disorders - Compositions and methods for treating disorders of the outer retina with compounds that inhibit monoamine oxidase are disclosed. | 06-30-2011 |
20110160172 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS - The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity. | 06-30-2011 |
20110151017 | OPHTHALMIC SOLUTIONS WITH IMPROVED DISINFECTION PROFILES - The present invention relates to ophthalmic solutions with antimicrobial activity. The solutions have an antimicrobial compound such as hydrogen peroxide and a boron compound. In one embodiment, the solutions contain a boron compound such as sodium borate that provides antimicrobial activity in addition to that of hydrogen peroxide, particularly during periods following disinfection and neutralization of such solutions. This additional activity reduces the likelihood of microbial growth in contact lens disinfection applications that neutralize hydrogen peroxide. | 06-23-2011 |
20110144641 | High-Intensity Pulsed Electric Field Vitrectomy Apparatus - A high-intensity pulsed electric field (HIPEF) vitrectomy apparatus is disclosed. An exemplary apparatus includes a HIPEF probe comprising at least one electrode disposed at a distal end of the HIPEF probe, such that the distal end is configured for insertion into an eye. Various embodiments include a probe shaft assembled from a modular end segment and one or more additional modular shaft segments, each of the modular end segment and one or more modular shaft segments in turn comprising at least two longitudinal channels adapted to accommodate an electrode unit. In some of these probe shafts, each of the modular end segment and one or more modular shaft segments has a central longitudinal channel, and the probe shaft further comprises an aspiration tube disposed within the central longitudinal channel. | 06-16-2011 |
20110144638 | Localized Shockwave-Induced Tissue Disruption - A high-intensity pulsed-electrical-field (HIPEF) apparatus removes ocular tissue from a localized portion of an eye by delivering one or more focused shockwaves to that tissue. In one embodiment, for example, the apparatus generates one or more electrical pulses, delivers the one or more focused shockwaves to ocular tissue by applying the generated electrical pulses to a HIPEF probe, and then removes the ocular tissue disrupted by the one or more focused shockwaves via aspiration. To mitigate risk of damage to adjacent ocular tissue, the apparatus delivers the one or more focused shockwaves with energy substantially limited to the tissue being removed. The HIPEF apparatus is, therefore, especially advantageous in the context of cataract surgery where cataract tissue need be broken apart and removed without damaging adjacent tissue associated with the lens capsule required to implant an intraocular lens. | 06-16-2011 |
20110144567 | Phacoemulsification Hand Piece With Integrated Aspiration Pump and Cartridge - An ophthalmic surgical hand piece comprises a driver coupled to a horn. The horn is coupled to a needle. An aspiration pump is integral with the hand piece and is located close to the needle. The aspiration pump comprises a motor coupled to a shaft. A removable cartridge comprises a length of flexible tubing held by a tubing holder. The length of flexible tubing is located between the shaft and the tubing holder. The removable cartridge comprises a section of an aspiration line. | 06-16-2011 |
20110144562 | Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields - A high-intensity pulsed-electrical-field (HIPEF) apparatus treats ocular tissue within a localized portion of an eye with a pharmacological solution. To mitigate risk of damage to adjacent, healthy ocular tissue, the apparatus delivers the solution to only a portion of the eye and then alters the effectiveness of at least some of the solution delivered by applying a HIPEF. In some embodiments, for example, the apparatus delivers an inactive pharmacological solution and then activates at least some of the solution by applying a HIPEF to that solution. As the apparatus applies the HIPEF with high precision, the HIPEF only activates solution within select portions of the eye. In other embodiments, the apparatus delivers a pharmacological carrier encapsulating an active pharmacological solution and then penetrates the carrier by applying a HIPEF. Delivered with a high concentration, but low dose, the solution diffuses only to tissue within a localized portion of the eye. | 06-16-2011 |
20110142767 | RNAi-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR ALPHA-RELATED CONDITIONS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example. | 06-16-2011 |
20110137232 | Thermal Management Algorithm For Phacoemulsification System - A control system for managing power supplied to a phacoemulsification hand piece includes a power source that provides power to the hand piece and a controller that controls the power source. The controller calculates a thermal value based on irrigation fluid flow and a power level and decreases the power level in proportion to the calculated thermal value when the calculated thermal value exceeds a threshold thermal value. Irrigation fluid flow can be calculated from irrigation fluid pressure. | 06-09-2011 |
20110137231 | Phacoemulsification Hand Piece With Integrated Aspiration Pump - An ophthalmic surgical hand piece comprises a driver coupled to a horn. The horn is coupled to a needle. An aspiration pump is integral with the hand piece and is located close to the needle. A rigid length of aspiration line is located between the aspiration pump and the needle. An optional pressure sensor is located between the aspiration pump and the needle as well. | 06-09-2011 |
20110135743 | CARBOXYVINYL POLYMER-CONTAINING NANOPARTICLE SUSPENSIONS - The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound. | 06-09-2011 |
20110135626 | Localized Chemical Lysis of Ocular Tissue - A high-intensity pulsed-electrical-field (HIPEF) apparatus chemically induces lysis of ocular tissue within a localized portion of an eye. Instead of broadly applying a lysis affecting solution (e.g., plasmin) to the eye, the apparatus delivers solution to only a portion of the eye. The apparatus then alters the effectiveness of at least some of the solution delivered by applying a HIPEF to that solution. In some embodiments, for example, the apparatus delivers a solution that does not substantially affect lysis of ocular tissue and then enhances the solution's effectiveness by applying a HIPEF. As the apparatus applies the HIPEF with high precision, the HIPEF only enhances the effectiveness of the solution within select and localized portions of the eye. The apparatus is especially advantageous for vitreoretinal surgery, whereby the apparatus may selectively induce lysis of vitreous tissue within a localized portion of the vitreous cavity, without significantly affecting adjacent retinal tissue. | 06-09-2011 |
20110135579 | RNAi-RELATED INHIBITION OF TNFa SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions associated with elevated intraocular pressure (IOP), including glaucoma and ocular hypertension. | 06-09-2011 |
20110124734 | N-HALOGENATED AMINO ACID FORMULATIONS AND METHODS FOR CLEANING AND DISINFECTION - The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent. | 05-26-2011 |
20110118734 | CAPSULARHEXIS DEVICE USING PULSED ELECTRIC FIELDS - A capsulorhexis apparatus is disclosed. An exemplary apparatus includes a cutting electrode device that in turn comprises a handle, a flexible ring having a single ring-shaped wire electrode embedded therein, and a shaft connecting the flexible ring to the handle, wherein the flexible ring is configured for insertion into an eye through an incision. The apparatus further includes a grounding electrode configured for placement in or on the eye, independently of the cutting electrode device, and a pulse generator electrically connected to the ring-shaped wire electrode and the grounding electrode and configured to supply pulsed power to the eye via the ring-shaped wire electrode and the grounding electrode | 05-19-2011 |
20110118729 | HIGH-INTENSITY PULSED ELECTRIC FIELD VITRECTOMY APPARATUS WITH LOAD DETECTION - A high-intensity pulsed electric field (HIPEF) vitrectomy apparatus is disclosed. An exemplary apparatus includes a HIPEF probe comprising at least one electrode disposed at a distal end of the HIPEF probe, such that the distal end is configured for insertion into an eye. A load detection circuit is coupled to the HIPEF probe and is configured to compare a measured physical parameter to a corresponding threshold value. A control circuit is electrically coupled to the load detection circuit and configured to selectively disable application of pulsed energy to the at least one electrode of the HIPEF probe, based on the comparison. The measured physical parameter may include, for example, resistivity, permittivity, reflected light, pressure, or heat dissipation capability. | 05-19-2011 |
20110118728 | CONTROL OF HIGH-INTENSITY PULSED ELECTRICAL FIELDS IN SURGICAL APPLICATIONS - An eye surgery apparatus includes a HIPEF probe comprising at least two electrodes and is configured for delivery of a high-intensity pulsed electrical field to a surgical site within an eye via the electrodes. Embodiments also include a transducer configured to monitor one or more surgical parameters within the eye during application of the high-intensity pulsed electrical field to the surgical site, a pulse generation circuit configured to generate a series of electrical pulses for application to the electrodes to create the high-intensity pulsed electrical field, and a control circuit, operatively connected to the at least one transducer and the pulse generation circuit and configured to automatically adjust one or more characteristics of the series of electrical pulses, based on the one or more monitored surgical parameters. With these apparatus, the amount of energy delivered can be limited to levels necessary for effective operation without over-exposing the vitreous. | 05-19-2011 |
20110112038 | NOVEL NPR-B AGONISTS - Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. | 05-12-2011 |
20110111055 | NUTRITIONAL SUPPLEMENTS FOR RELIEF OF DRY EYE - The present invention provides improved dietary supplements and methods for alleviating the symptoms of dry eye. The dietary supplements of the invention contain omega-3 fatty acids and flavonoids. | 05-12-2011 |
20110105574 | PAI-1 EXPRESSION AND ACTIVITY INHIBITORS FOR THE TREATMENT OF OCULAR DISORDERS - The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that inhibits PAI-1 expression or PAI-1 activity. Another embodiment of the present invention is a method of treating a PAI-1-associated ocular disorder in a subject in need, comprising administering to the patient an effective amount of a composition comprising an agent that inhibits PAI-1 activity or expression. | 05-05-2011 |
20110104154 | SINGLE NUCLEOTIDE POLYMORPHISMS AND GENES ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION - The invention provides genes and polymorphisms associated with AMD, and methods for diagnosing an increased risk of AMD in a patient who has at least one of the AMD-associated polymorphisms as provided. | 05-05-2011 |
20110092523 | AGENTS WHICH REGULATE, INHIBIT, OR MODULATE THE ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS A UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHIES/OPTIC NEUROPATHIES - The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF). | 04-21-2011 |
20110082145 | OLOPATADINE COMPOSITIONS AND USES THEREOF - The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula I: | 04-07-2011 |
20110082125 | Topical Ophthalmic or Otic Solution Formulations Containing Moxifloxacin Hydrocholoride and Dexamethasone Phosphate - Topical ophthalmic and otic solution compositions of moxifloxacin and dexamethasone phosphate are disclosed. | 04-07-2011 |
20110082092 | INTERFERING RNA DELIVERY SYSTEM AND USES THEREOF - The invention provides a delivery system comprising a cell penetrating peptide, a polyarginine peptide, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided. | 04-07-2011 |
20110077381 | NOVEL NPR-B AGONISTS - Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. | 03-31-2011 |
20110071459 | Power Saving Glaucoma Drainage Device - A glaucoma drainage device has an active valve configured to be located between an anterior chamber of an eye and a drainage location, a power source coupled to the active valve, and a controller coupled to the power source. A first pressure sensor is located in fluid communication with the anterior chamber, a second pressure sensor is located in the drainage location, and a third pressure sensor located remotely from the first and second pressure sensors. The controller reads the first, second, and third pressure sensors once during a period of time and adjusts the active valve to control intraocular pressure. | 03-24-2011 |
20110071458 | Glaucoma Drainage Device with Pump - A glaucoma drainage device may comprise a main drainage tube with a first end configured to be located in an anterior chamber of an eye and a second end configured to be located in a drainage location. A bypass drainage tube is fluidly coupled to and in parallel with the main drainage tube. A pump is in communication with the bypass drainage tube. The pump comprises a first driver and a first flexible membrane enclosing a first chamber. A first check valve is located upstream of the pump, and a second check valve is located downstream of the pump. An active valve is located upstream of the first check valve. The active valve comprises a second driver and a second flexible membrane enclosing a second chamber. A third check valve is located between the active valve and the second end of the main drainage tube. A volume of the first chamber is changed to pump fluid from the anterior chamber to the drainage location. | 03-24-2011 |
20110071454 | Power Generator For Glaucoma Drainage Device - A glaucoma drainage device has a tube shunting the anterior chamber to a drainage location. A power generator has a rotor coupled to a micro-generator. The power generator is configured to generate energy from aqueous flowing through the tube. The force required to drive the rotor can be controlled to control the flow of aqueous through the tube. Alternatively, energy generated by the power generator is stored in a power source that powers an active valve, a pressure sensor, or telemetry. | 03-24-2011 |
20110071116 | ANTIMICROBIAL N-HALOGENATED AMINO ACID SALTS - The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens. | 03-24-2011 |
20110060044 | ALIPHATIC ACID-CONTAINING N-HALOGENATED AMINO ACID FORMULATIONS - The present invention relates to methods for treating an infected tissue comprising treating the infected tissue with a formulation comprising a N-halogenated amino acid and an aliphatic acid. This specification also discloses methods for improving the antimicrobial activity of a formulation comprising a N-halogenated amino acid, the method comprising adding an aliphatic acid to said formulation. | 03-10-2011 |
20110059039 | USE OF PEO-PBO BLOCK COPOLYMERS IN OPHTHALMIC COMPOSITIONS - The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention. | 03-10-2011 |
20110009322 | USE OF BRADYKININ AND RELATED B2R AGONISTS TO TREAT OCULAR HYPERTENSION AND GLAUCOMA - The invention provides methods for treating and/or preventing ocular disorders associated with increased intraocular pressure comprising administering a bradykinin B | 01-13-2011 |
20110008276 | ETHYLENEOXIDE BUTYLENEOXIDE BLOCK COPOLYMER COMPOSITIONS - The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated. | 01-13-2011 |
20110003803 | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC, OTIC, OR NASAL INFECTIONS - The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections. | 01-06-2011 |
20100305193 | RNAI-MEDIATED INHIBITION OF GREMLIN FOR TREATMENT OF IOP-RELATED CONDITIONS - RNA interference is provided for inhibition of gremlin in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma. | 12-02-2010 |
20100303930 | N-HALAMINE FORMULATIONS WITH ENHANCED ANTIMICROBIAL ACTIVITY - The present invention relates to antimicrobial formulations comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine. The present invention is further directed to formulations for disinfecting a contact lens comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine. | 12-02-2010 |
20100267811 | RNAi-RELATED INHIBITION OF TNFa SIGNALING PATHWAY FOR TREATMENT OF OCULAR ANGIOGENESIS - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy. | 10-21-2010 |
20100266664 | Devices And Methods For Ophthalmic Drug Delivery - Disclosed are ophthalmic drug-delivery devices, comprising a body having a proximal end and a distal end, wherein the body includes a styrene elastomer matrix and a drug in contact with the matrix. Also disclosed are methods of treating or preventing an eye disease in a subject, that involve contacting an eye of the subject with an ophthalmic drug delivery device comprising a body having a proximal end and a distal end, wherein the body comprises a styrene elastomer matrix and a drug in contact with the matrix, wherein release of the drug from the device occurs over time following contacting of the device with the eye of the subject. | 10-21-2010 |
20100260784 | PAI-1 BINDING MODULATORS FOR THE TREATMENT OF OCULAR DISORDERS - The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 binding to vitronectin. In another embodiment, the invention concerns a method of manufacturing a compound to be used as a treatment for glaucoma or elevated IOP comprising providing a candidate substance suspected of modulating PAI-1 binding, selecting the compound by assessing the ability of the candidate substance to decrease the amount of active PAI-1 in the trabecular meshwork of a subject suffering from glaucoma or elevated PAI-1, and manufacturing the selected compound. | 10-14-2010 |