AGILENT TECHNOLOGIES, INC. Patent applications |
Patent application number | Title | Published |
20160096200 | System and Method for Facilitating Manual Sorting of Objects - An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated object is to be moved. In one aspect of the invention, the display surface includes an area adapted for positioning a receiver for the objects. The display surface provides an indication of a position in the receiver at which the one of the objects is to be placed. | 04-07-2016 |
20160091704 | Mid-Infrared Scanning System - An apparatus and method for generating a mid-infrared region image of a specimen are disclosed. The apparatus includes a mid-infrared region laser that generates a first light beam, and a stage adapted to carry a specimen to be scanned. An optical assembly focuses the first light beam to a point on the specimen. A first light detector measures a first intensity of light leaving the point on the specimen. A stage actuator assembly causes the specimen to move relative to the point in two dimensions. A controller forms a mid-infrared region image from the first intensity. The image can be based on reflected or transmitted light. The maximum size of the imaged area is determined by a scanning assembly that moves in a first direction relative to the stage, the stage moving in a direction orthogonal to the first direction. | 03-31-2016 |
20160024529 | METHODS OF IN VIVO ENGINEERING OF LARGE SEQUENCES USING MULTIPLE CRISPR/CAS SELECTIONS OF RECOMBINEERING EVENTS - The present invention provides a method for making a large nucleic acid having a defined sequence in vivo. The method combines recombineering techniques with a CRISPR/Cas system to permit multiple insertions of defined sequences into a target nucleic acid at one time, double stranded cleavage of target nucleic acids in which the defined sequences were not successfully inserted, and selection of successful recombinant cells. The method further includes repeating the process one or more times, using a successful recombinant from one round as the host cell for the next round. | 01-28-2016 |
20160017405 | FAST HYBRIDIZATION FOR NEXT GENERATION SEQUENCING TARGET ENRICHMENT - The present invention relates to compositions and methods of target enrichment or selection of nucleic acids using hybridization, which can be used in, e.g., next-generation sequencing. | 01-21-2016 |
20150370234 | DIGITAL TRIGGERING USING FINITE STATE MACHINES - An apparatus that can be configured for various functions such as a digital oscilloscope, logic analyzer or frequency analyzer is disclosed. The apparatus includes a symbol generator, a multi-symbol FSM, and a controller. The symbol generator generates an ordered sequence of symbols from an ordered sequence of digital values. The symbol generator generates one symbol corresponding to each of the digital values. The digital values have a greater number of possible values than the symbols. The controller causes the multi-symbol FSM to search for a pattern in the sequence of symbols that identifies a corresponding pattern in the sequence of digital values. A portion of the digital sequence is then displayed based on the location of the pattern in the sequence of symbols. | 12-24-2015 |
20150346148 | Method and Apparatus for Manipulating Samples Using Optoelectronic Forces - An apparatus for controlling the motion of a particle and a method for using the same are disclosed. The apparatus includes a channel containing liquid between first and second electrodes. The apparatus also includes an array of variable impedance elements, each variable impedance element connecting the first electrode to a corresponding location in the channel by a path having an average impedance that is continuously variable between first and second impedances when averaged over an update time interval. A controller sets the average impedance of each of the variable impedance elements such that a particle in the channel moves in a predetermined direction when voltage is applied between the first and second electrodes. At least one of the variable impedance elements has an average impedance that is intermediate between the first and second impedances. | 12-03-2015 |
20150323532 | MULTIPLE EPITOPE DETECTION IN AN FFPE TISSUE SECTION - A method for labelling a tissue section is provided. In certain embodiments, the method may comprise: (a) labeling a formalin-fixed paraffin embedded (FFPE) tissue section using a first set of labeling reagents that comprises a first primary antibody and a first labeled secondary antibody; (b) treating the labeled tissue with a protease, thereby digesting the first primary antibody and/or the first labeled secondary antibody and separating the label from the FFPE tissue section; (c) washing the tissue section to remove the separated label and the protease; and (c) labeling the FFPE tissue section using a second set of labeling reagents that comprises a second primary antibody and a second labeled secondary antibody. A kit for performing the method is also provided. | 11-12-2015 |
20150282289 | WAVEGUIDE-BASED APPARATUS FOR EXCITING AND SUSTAINING A PLASMA - An apparatus includes an electromagnetic which supports propagation of an electromagnetic wave in a first direction between a first end thereof and a second end thereof, and an electromagnetic-field shaping structure within the electromagnetic waveguide. The electromagnetic-field shaping structure defines a channel extending from a first aperture in a first wall of the apparatus to a second aperture in a second, opposite, wall. The channel has an axis extending in a second direction which is nonparallel with the first direction. The distance between the first aperture and the second aperture in the second direction is less than the width of the interior region of the waveguide at the first and second ends thereof. In some embodiments, a plasma torch is disposed within the channel. The length of the torch closely matches its interaction region. | 10-01-2015 |
20150281983 | Method and Apparatus for Determining the Configuration of a Cellular Transmission System - A method for operating a data processing system to determine the operational parameters of a communication system between an REC and an RE that utilizes a CPRI data link for communication. The data processing system is synchronized with the CPRI frames and determines a plurality of CPRI frame characteristics from the CPRI frames by examining a plurality of predetermined locations in the CPRI frames. The plurality of CPRI frame characteristics for one or more of the CPRI frames, and a first model of the communication system are used to generate a first broadcast frame that would be generated by the one or more CPRI frames if the first model accurately described the communication system. The first broadcast frame is tested to determine if the first broadcast frame is consistent with the first model. If the broadcast frame is inconsistent, a new model is chosen and the process repeated. | 10-01-2015 |
20150244150 | METHOD AND APPARATUS TO REDUCE NOISE CAUSED BY MODE HOPPING IN EXTERNAL CAVITY LASERS - An external cavity laser and method for operating same are disclosed. The external cavity laser includes a gain chip, a grating, an actuator and actuator driver. The grating diffracts light leaving the gain chip in a band of wavelengths back to the gain chip, the grating is characterized by an angle relative to light leaving the gain chip and distance from the gain chip, the angle and distance is controlled by the actuator. Part of the diffracted light is amplified by the gain chip. The actuator driver causes the angle to be dithered about an equilibrium angle in a motion characterized by an amplitude and average frequency. The amplitude of the dithering motion is chosen to either excite a plurality of adjacent laser modes of the gain chip or provide a servo signal for maintaining the grating angle at a target value. | 08-27-2015 |
20150232821 | Thermostable Type-A DNA Polymerase Mutant with Increased Resistance to Inhibitors in Blood - The invention provides mutants of DNA polymerases having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases. | 08-20-2015 |
20150226667 | Spectrographic System Utilizing a Chirped, Pulsed Optical Source - An apparatus and method for measuring the attenuation and dispersion introduced by a sample into an optical signal are disclosed. The apparatus includes a chirped light source, a beam splitter and an optical detector. The beam splitter splits the optical signal generated by the light source into a reference optical signal and a sample optical signal. The sample and reference optical signals are mixed on the detector after the sample optical signal has traversed an experimental sample thus generating a signal having an AC component related to an attenuation and a dispersion introduced by the experimental sample. The optical paths traversed by the reference and sample optical signals between the beam splitter and the detector are chosen such that the reference optical signal and the sample optical signal overlap in time but do not arrive at the optical detector at the same time. | 08-13-2015 |
20150226606 | Method and Apparatus for Reducing Pointing-Error Noise - An apparatus having a variable angle light source characterized by a pivot point, a variable response optical receiver, and a first optical system is disclosed. The variable response optical receiver receives light generated by the light source on a receiving surface, the receiver generating a signal indicative of an intensity of light that impinges on a receiving surface. The first optical system images the pivot point to a fixed point relative to the receiver surface. In one aspect of the invention the first optical system is chosen such that light from the variable angle light source covers mores than half the receiving surface. The variable angle light source can include a gain chip in a semiconductor laser having a pivot point located substantially on a facet of the gain chip. | 08-13-2015 |
20150219598 | FAST METHOD FOR MEASURING COLLISION CROSS SECTION OF IONS UTILIZING ION MOBILITY SPECTROMETRY - The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion. | 08-06-2015 |
20150211058 | CAS9-based Isothermal Method of Detection of Specific DNA Sequence - The present invention relates to an isothermal method for detecting in a sample a target nucleic acid strand. | 07-30-2015 |
20150211047 | FAST HYBRIDIZATION FOR NEXT GENERATION SEQUENCING TARGET ENRICHMENT - The present invention relates to compositions and methods of target enrichment or selection of nucleic acids using hybridization, which can be used in, e.g., next-generation sequencing. | 07-30-2015 |
20150204828 | FLUIDIC VALVE WITH SELECTIVLY SWITCHABLE STORAGE PATHS - A sample separation apparatus ( | 07-23-2015 |
20150198572 | CHROMATOGRAPHIC SYSTEM AND METHOD OF ISOLATING COMPOUND IN SAMPLE USING CHROMATOGRAPHIC SYSTEM - A method is provided for isolating a compound in a sample by chromatography. The method includes determining an analytical gradient of an analytical system; performing an analytical run using the analytical gradient; identifying a target compound in the sample and determining an analytical retention time of the target compound using chromatographic results of the analytical run; determining an elution point of the target compound using the analytical retention time, the analytical gradient and characteristics of the analytical system; determining automatically a focusing gradient of a preparative system, including a slope segment; and performing a preparative run using the focusing gradient to separate the target compound from the sample. The slope segment includes a slope determining a concentration of solvent in a solvent mixture, which linearly increases from a first offset below the elution point of the target compound to a second offset above the elution point of the target compound. | 07-16-2015 |
20150145246 | SINGLE-PIECE FERRULE WITH UNDERCUT TAPERING PART - A single-piece ferrule for a fitting for coupling a capillary to another component of a fluidic device, wherein the ferrule comprises a ferrule body, wherein the ferrule body has a lumen configured for receiving at least a part of the capillary, wherein the ferrule body has a tapering front part configured for forming a sealed connection with a housing of the fitting, wherein a back side of the tapering front part has an annular undercut. | 05-28-2015 |
20150138548 | OPTICAL EMISSION SYSTEM INCLUDING DICHROIC BEAM COMBINER - An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second light into the entrance aperture, enabling analysis and measurement of both first and second light characteristics simultaneously. The portion of the first light reflected into the entrance aperture predominately has wavelengths in a first range of wavelengths and the portion of the second light transmitted into the entrance aperture predominately has wavelengths in a second range of wavelengths, different from the first range of wavelengths. | 05-21-2015 |
20150138533 | OPTICAL ABSORPTION SPECTROMETRY SYSTEM INCLUDING DICHROIC BEAM COMBINER AND SPLITTER - An optical absorption spectrometry system includes first and second light sources, a dichroic beam combiner and a wavelength selective module. The first light source emits first light having first wavelengths within a first wavelength range, and the second light source emits second light having second wavelengths within a second wavelength range different from the first wavelength range. The dichroic beam combiner includes a predetermined first reflectance/transmission transition region, the dichroic beam combiner being configured to transmit a first portion of the first light and to reflect a second portion of the second light to provide combined light. The wavelength selective module is configured to disperse the combined light received at an entrance aperture, to select a sample wavelength range of the dispersed light as sample light, and to output the sample light having the selected sample wavelength range from an exit aperture for illuminating a sample. | 05-21-2015 |
20150090595 | FITTING FOR ELASTICALLY-BIASING A CAPILLARY FOR A FLUID-TIGHT CONNECTION TO A FLUIDIC CONDUIT - A fitting ( | 04-02-2015 |
20150062586 | SYSTEM FOR PERFORMING OPTICAL SPECTROSCOPY INCLUDING INTERFEROMETER - A system for performing optical spectroscopy measurements includes a light source for generating an input optical beam and an interferometer. The interferometer includes a beam splitter that splits the input optical beam into first and second light beams; a first light path that directs the first light beam through a sample containing an analyte to a first output port; and a second light path that directs the second light beam to the first output port. At least one of the first and second light paths adjusts a relative phase of a corresponding one of the first and second light beams, so that the first and second light beams are out of phase at the first output port, substantially canceling background light and outputting sample light corresponding to a portion of the first light signal absorbed by the sample in the sample cell. A detection system detects the output sample light. | 03-05-2015 |
20150060656 | ION DEFLECTION IN TIME-OF-FLIGHT MASS SPECTROMETRY - A time-of-flight mass spectrometry (TOF MS) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor. The deflector deflects ions away from a main flight path such that the defected ions are not detected. | 03-05-2015 |
20150028222 | PLASMA-BASED PHOTON SOURCE, ION SOURCE, AND RELATED SYSTEMS AND METHODS - A photon source includes a plasma source for generating plasma and a photon guide through which the plasma travels. The photon guide includes an inner surface configured for reflecting photons emitted from the plasma. As the plasma travels through the photon guide, plasma electrons and ions recombine at the inner surface, whereby the predominant species emitted from an outlet of the photon guide are the photons and neutral particles, with few or no plasma electrons and ions being emitted. | 01-29-2015 |
20140375050 | QUICK LOCK CONNECTOR FOR CONNECTING A CAPILLARY TO A FLUIDIC CONDUIT OF A FLUIDIC COMPONENT - A fitting ( | 12-25-2014 |
20140368904 | Software Defined Microscope - A microscope having a first illumination spatial light modulator (SLM) that receives light of a first wavelength from an illumination source and processes that light in a manner that transfers light into an objective lens through a dichroic reflector that passes light of the first wavelength is disclosed. The microscope includes an imaging system that receives light from the objective lens and forms an image on a camera, and a controller having a graphical user input that displays the image to a user and controls the first illumination SLM to alter the processing of the light in response to commands from the user. The illumination SLM is controlled to provide functions that would normally be carried out by one or more lenses or prisms in the illumination optical train of a conventional microscope and/or correct for alignment errors in the illumination source. | 12-18-2014 |
20140366739 | HPLC SAMPLE INTRODUCTION WITH BYPASS CHANNEL - A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel. | 12-18-2014 |
20140357523 | METHOD FOR FRAGMENTING GENOMIC DNA USING CAS9 - A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic DNA with a plurality of Cas9-gRNA complexes, wherein the Cas9-gRNA complexes comprise a Cas9 protein and a set of at least 10 Cas9-associated guide RNAs that are complementary to different, pre-defined, sites in a genome, to produce a reaction mixture; and (b) incubating the reaction mixture to produce at least 5 fragments of the genomic DNA. Also provided is a composition comprising at least 100 Cas9-associated guide RNAs that are each complementary to a different, pre-defined, site in a genome. Kits for performing the method are also provided. In addition, other methods, compositions and kits for manipulating nucleic acids are also provided. | 12-04-2014 |
20140356867 | NUCLEIC ACID ENRICHMENT USING CAS9 - A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA that is complementary to a site in the DNA, to produce a Cas9-fragment complex that comprises a fragment of the fragmented DNA; and (b) isolating the complex. In addition, other methods and compositions for Cas9/CRISPR-mediated nucleic acid manipulation are also provided. | 12-04-2014 |
20140322056 | VACUUM PUMP HAVING EXPANSION CHAMBER AND METHOD OF ACHIEVING ULTIMATE PRESSURE STATE IN A VACUUM PUMP USING AN EXPANSION CHAMBER - A vacuum pump and a method of controlling the operation of the vacuum pump employ an expansion chamber to reduce a pressure differential between an inlet side and an exhaust side of the pump. In particular, the expansion chamber may be used to rid the pump head of the pump of a pocket of relatively high pressure fluid that accumulates behind a poppet valve disposed over an exhaust opening. The pump itself may be used to create a level of vacuum pressure in the expansion chamber. Alternatively, a piston or diaphragm may be used. In either case, the expansion chamber is isolated from the ambient and interior of the pump head once a level of vacuum pressure is produced in the expansion chamber. Then the exhaust outlet is redirected from the ambient to the interior of the expansion chamber. | 10-30-2014 |
20140320157 | OSCILLOSCOPE PROBE HAVING OUTPUT CLAMPING CIRCUIT - A probe for a measurement instrument comprises an input terminal configured to receive an input signal from a device under test (DUT), an output terminal configured to transmit an output signal to a measurement instrument, and a clamping circuit disposed in a signal path between the input terminal and the output terminal and configured to clamp an internal probe signal between an upper clamping threshold and a lower clamping threshold to produce the output signal, wherein the clamping circuit operates with substantial gain and amplitude linearity throughout a range between the upper clamping threshold and the lower clamping threshold. | 10-30-2014 |
20140320153 | Oscilloscope Current Probe with Interchangeable Range and Sensitivity Setting Modules - An oscilloscope current probe system includes a probe amplifier unit, a probe head identifier, and first and second probe heads interchangeably connectable to the probe amplifier unit. Each probe head has a respective electrically-readable type identifier, a respective current input to receive a current to be measured, a respective internal sensing resistor in connected series with the current input, and a respective output at which a measurement voltage across the sensing resistor is output. The first and second probe heads differ in the resistance of their sensing resistors and the way their type identifiers read. The probe amplifier unit includes a differential amplifier to amplify the measurement voltage output by the probe head connected thereto. The probe head identifier is to read the type identifier of the probe head connected to the probe amplifier unit. | 10-30-2014 |
20140320145 | OSCILLOSCOPE SYSTEM AND METHOD FOR SIMULTANEOUSLY DISPLAYING ZOOMED-IN AND ZOOMED-OUT WAVEFORMS - An oscilloscope system includes a current probe, a processing unit and a display unit. The current probe includes a high and low gain signal paths for receiving simultaneously a signal of interest from a device under test (DUT), and to output amplified small and large current portions of the signal of interest, respectively. The processing unit receives first and second digitized data corresponding to the amplified small and large current portions output by the high and low gain signal paths, respectively, and processes the first and second digitized data for display as zoomed-in and zoomed-out waveform data, respectively. The display unit displays simultaneously a zoomed-in waveform in a first display window, based on the zoomed-in waveform data, and a zoomed-out waveform in a second display window, based on the zoomed-out waveform data, using the same time scale. The small current portion is less than a predetermined threshold. | 10-30-2014 |
20140312937 | Multi-Band Frequency Multiplier - A multi-band frequency multiplier configured to generate frequencies and multiplied frequencies in an integrated system. The multi-band frequency multiplier includes a multi-band multiplier core with a multiplier core differential amplifier configured to receive a multiplier input signal. A switchable load impedance connects to the multiplier core differential amplifier, and includes n multiplier sections. Each multiplier section includes a section impedance and a section switch. The multiplier core differential amplifier generates an output signal having a frequency substantially equal to k times the input frequency in a range of a selected one of n critical frequencies when a selected one of the section switches corresponding to the selected one of the n critical frequencies is triggered. | 10-23-2014 |
20140306719 | CALIBRATION OF TEST INSTRUMENT OVER EXTENDED OPERATING RANGE - A method of calibrating a test instrument comprises determining a first response of a calibration device on the test instrument over a first set of operating ranges, determining a derived second response of the calibration device on the test instrument over a second set of operating ranges based on the first response, measuring the second response of the calibration device on the test instrument over the second set of operating ranges, and determining correction factors of the test instrument for the second set of operating ranges based on a comparison between the measured second response and the derived second response. | 10-16-2014 |
20140303922 | Integrated Tool for Compliance Testing - A method for operating a data processing system to perform compliance testing of an instrument system is disclosed. The instrument system includes an underlying instrument and a computerized data system (CDS) that controls the underlying instrument. The method includes causing data indicative of a measurement made on a test sample by the underlying instrument to be received by the data processing system. The data processing system then performs data reduction computations on the received data while the received data is in a technology neutral format using the data processing system to generate one or more outputs in a technology neutral format. A final report in a technology neutral format is then generated with the one or more outputs. The data processing system can be separate from the CDS or a program that runs under the CDS. | 10-09-2014 |
20140301879 | Angular Synchronization of Stationary and Orbiting Plate Scroll Blades in a Scroll Pump Using a Metallic Bellows - Parts of a pump head of a scroll pump facilitate an assembly process in which the stationary and orbiting scroll blades of the pump are angularly aligned or synchronized with one another. A metallic bellows of the pump head provides a primary means of synchronizing the stationary and orbiting scroll blades. The assembly process may be carried out using a fixture configured to be mountable to an assemblage including the bellows and the orbiting plate scroll. The fixture has a reference feature, and the orbiting plate scroll or the frame has another reference feature that can be aligned with the reference feature of the fixture, in the circumferential direction of the bellows, during the course of the assembly process. | 10-09-2014 |
20140294638 | Thermal/Noise Management in a Scroll Pump - The speed of a cooling fan of a scroll pump is controlled such that fan-generated noise can be kept low. The scroll pump includes a pump head, a pump motor, the fan, a controller and one or more sensors. The pump head includes a plate scroll set in which a tip seal is provided to create a seal between the blade and the opposing plates of the plate scrolls of the set. The speed of the fan is cycled by the controller, and the power draw on the pump motor as a result is checked. These results are used to infer the state of the pump, i.e., to discriminate several different states of the pump from one another, including a state in which a new tip seal is being worn in, and to control the speed of the fan accordingly. | 10-02-2014 |
20140294623 | Thermal/Noise Management in a Scroll Pump - The main sources of heat in a scroll pump are cooled efficiently by a single cooling fan so that noise and, in particular, fan-generated noise, can be kept low. The scroll pump includes a pump head assembly, a pump motor, a cooling fan that produces a cooling air flow in the pump, a cowling in which the pump head assembly, pump motor and cooling fan are housed and juxtaposed with one another in an axial direction of the pump, and a shroud disposed within the cowling and extending around the pump motor to define a tunnel with the motor and through which the air flow of the cooling fan is directed. | 10-02-2014 |
20140292186 | VACUUM FIRED AND BRAZED ION PUMP ELEMENT - A Vacuum Fired and Brazed (“VFB”) anode array element for use in an ion pump is described. The VFB anode array element includes a first VFB conduit anode element and second VFB conduit anode element, wherein the second VFB conduit anode element is adjacent the first VFB conduit anode element. The first VFB conduit anode element is vacuum brazed together with second VFB conduit anode element. | 10-02-2014 |
20140282133 | Method for Creating a User Interface - A method of operating a data processing system having a control screen to provide control of a program is disclosed. First and second program graphical user interfaces (GUIs) and a runtime library are provided. The first program GUI includes a first GUI description and a first method for operating on data input to or data output from that the first program GUI. The second program GUI includes a second GUI description and a second method for operating on data input to or data output from that the second program GUI. The runtime library includes the first and second method. The data processing system combines the first GUI description and the second GUI description to provide a compound GUI without recompiling the runtime library. | 09-18-2014 |
20140282055 | Layout System for Devices with Variable Display Screen Sizes and Orientations - A method for operating a data processing system having a display screen on which a GUI is displayed is disclosed. The GUI has a plurality of configurations having different aspect ratios or numbers of pixels. The method includes providing a layout description and a runtime system that generates the GUI in response to the layout description and the display configuration. The layout description defines a first container having a plurality of components to be shown in the GUI within a first container space. Each component has a component layout description within the first container. The runtime system automatically allocates the first container space depending on the display configuration, and automatically divides the first container space into plurality of component spaces. Each component is shown in a corresponding one of the component spaces. The first container space and the component spaces automatically change when the display configuration changes. | 09-18-2014 |
20140273252 | ION MOBILITY MASS SPECTROMETRY TAGS FOR QUANTITATIVE APPLICATIONS AND METHODS THEREOF - Compound tags and shifting agents are provided that find use in ion mobility spectrometry (IMS), mass spectrometry (MS), or a combination of IMS and MS, and which can substantially increase separation of multiple components in complex samples and facilitate quantitative and multiplexed analyses. In some cases, the compounds include a linker and a normalizing group, each including a structural unit and separated by a cleaveable group, and a crown ether. Also provided are methods for analyzing peptides in a sample. In some cases, the method includes coupling the compound to peptides which include a terminal guanidinium moiety capable of forming an intra-molecular complex with the crown ether. | 09-18-2014 |
20140273080 | METHOD FOR METABOLOMIC SAMPLE PREPARATION BASED ON IONIC LIQUID DISPERSIVE LIQUID-LIQUID MICROEXTRACTION - Provided herein is a method comprising one or more of the following steps: (a) lysing cells of a biological sample and contacting the biological sample with an amount of ionic liquid sufficient to denature intracellular metabolic enzymes in the biological sample to produce a contacted cellular sample; (b) mixing the contacted cellular sample with an organic solvent to produce an ionic liquid-organic solvent composition; (c) mixing the contacted cellular sample with the organic solvent to produce a dispersed microdroplet ionic liquid-organic solvent composition; (d) contacting the ionic liquid-organic solvent composition with an ion exchange composition to produce a second ionic liquid-organic solvent composition; (d) separating the ionic liquid from the organic solvent; and (e) extracting metabolites from the ionic liquid. Kits and systems for practicing the subject methods are also provided. | 09-18-2014 |
20140271305 | Scroll Pump Having Bellows Providing Angular Synchronization and Back-up System For Bellows - A scroll pump has a metallic bellows that angularly synchronizes the stationary and orbiting scroll blades of the pump, and a hack-up system for the bellows. The back-up system consists of pins integral with and fixed relative to one of the stationary and orbital parts of the scroll pump, and a guide part that is integral with and fixed relative to the other of the stationary and orbital parts. The back-up system may be a non-contacting hack-up system in which there is no contact between the pins and guide part during normal operation of the pump. Therefore, no particles are created by a wearing away of such parts which would otherwise have the potential to contaminate the fluid being worked by the pump and reduce the useful life of the pump. | 09-18-2014 |
20140271242 | VIBRATION/NOISE MANAGEMENT IN A SCROLL COMPRESSOR - A scroll pump isolates vibrations of a pump head/motor assembly of the pump from the exterior of the pump and thus, suppresses the production of airborne noise. The pump includes a sound-muffling enclosure surrounding the pump head/motor assembly, feet supporting the enclosure, and elastic vibration isolators. The pump head/motor assembly is fixed to the tops of the vibration isolators, and the sound-muffling enclosure is fixed to the vibration isolators at the bottoms of the isolators. The scroll pump also has a locking system by which motion of the pump head/motor assembly relative to the sound-muffling enclosure can be limited or prevented, and by which the sound-muffling enclosure can be hard-mounted to a support surface independently of the feet. | 09-18-2014 |
20140271233 | MODULAR PUMP PLATFORM - A modular pump platform includes a pump head module, a pump motor module, an electronics module and a separable tray. The pump motor module includes a pump motor having a rotary output removably coupled to a crank shaft of the pump head, the pump motor being one of multiple types of pump motors, and the pump motor module being detachably connected to the pump head module. The electronics module includes an electronic control circuit configured control operation of the pump motor, the electronic control circuit being one of multiple types of electronic control circuits corresponding to the types of pump motors. Each of the pump head module, the pump motor module and the electronics module is detachably connected to the separable tray. At least the pump motor module is interchangeable with another pump motor module comprising a pump motor of another type. | 09-18-2014 |
20140271106 | Pump Testing for Predicting Lifetime and Wear Conditions - System and method for testing a pump. The testing of the pump includes determining a Mechanical Power Index (MPI) for the pump. The MPI is determined by operating the pump at operating speed for a minimum operating interval. When the pump is stopped under normal operation by the application, the pump speed is continuously monitored. The time when the pump speed decreases to an initial speed close to the operating speed is read as an initial time. When the pump speed decreases to a final pump speed close to the critical speed, the end time is read and the elapsed time is determined as Δt=end time−initial time. The MPI is calculated to be the initial pump speed minus the final pump speed divided by Δt. The MPI can be used during the lifetime of the pump to determine when the pump is deteriorating. | 09-18-2014 |
20140266499 | ADJUSTABLE DIRECTIONAL COUPLER CIRCUIT - An adjustable directional coupler circuit includes a directional coupler and a correction circuit. The directional coupler includes a first port for receiving an input signal; a second port for outputting the input signal to a load; a third port for outputting a first coupled signal including a desired first coupled signal proportional to forward power of the input signal and an extraneous first coupled signal proportional to reverse power of a reflected signal; and a fourth port for outputting a second coupled signal including a desired second coupled signal proportional to the reverse power and an extraneous second coupled signal proportional to the forward power. The correction circuit adjusts magnitude and phase of a sample of the second coupled signal to provide an adjusted second coupled signal, and to sum the adjusted second coupled signal and the first coupled signal to cancel the extraneous first coupled signal. | 09-18-2014 |
20140266282 | Test System for Improving Throughout or Maintenance Properties of Semiconductor Testing - A semiconductor test system includes test head pins; per-pin resources which are connectable to the test head pins on a one-to-one basis; shared resources, each of which is connectable to one of the test head pins; a tester controller for controlling the per-pin resources and the shared resources; and a tabular-form test plan including: a first column for specifying a measurement function that uses at least one of the per-pin resources and the shared resources; and at least one second column for specifying input and output parameters of the measurement function, the tabular-form test plan further including program rows, the tabular-form test plan being executed by the tester controller, the tabular-form test plan further including a third column for specifying how rows that are executed by asynchronous parallel execution are to be grouped. | 09-18-2014 |
20140263202 | Integrated Magnetron Plasma Torch, and Related Methods - A plasma source for generating microwave-induced plasma includes a plasma torch integrated with a microwave energy source. The torch establishes a gas flow path from one side of the plasma source to the other side. The torch may be integrated with the microwave energy source such that a plasma-forming gas flowing through the torch is subjected to microwave radiation, which serves to initiate and/or sustain plasma in the torch. The plasma may be ejected from the torch and utilized in various applications involving the use of plasma, including analytical techniques such as optical emission spectrometry and mass spectrometry. | 09-18-2014 |
20140260540 | SAMPLE INLET WITH MULTI-CAPILLARY LINER FOR GAS CHROMATOGRAPHY - A gas chromatograph (GC) inlet device includes a multi-capillary liner capable of separating components of a sample matrix prior to injecting the sample into an analytical GC column. The device is switchable between different modes, such as a normal injection modes, splitless modes, split modes, a backflush modes, and cut modes. | 09-18-2014 |
20140255924 | TWIST-TIE OLIGONUCLEOTIDE PROBES - A composition comprising population of labeled oligonucleotides is provided herein. In some embodiments, the probes are of the formula: T | 09-11-2014 |
20140251448 | PACKET-WISE PROPORTIONING FOLLOWED BY IMMEDIATE LONGITUDINAL MIXING - A fluid supply system ( | 09-11-2014 |
20140251056 | ROBOTIC ARM ASSEMBLY WITH ANGULAR CONTACT CARTRIDGE BEARINGS - A robotic arm assembly includes a first arm and second arm coupled by a shaft and bearing assembly, forming a joint at which the first arm rotates about a joint axis. The bearing assembly includes angular contact cartridge bearings contacting corresponding angled surfaces of the assembly, and a bearing cap. The shaft is attached to the first arm, extends through the second arm, and is attached to the bearing cap such that the bearing assembly is axially compressed between the bearing cap and the first arm. The bearing assembly may include components for preloading the bearing assembly and enabling components to self-align during assembly. | 09-11-2014 |
20140251033 | SAMPLE TUBE HOLDER PROVIDING ZERO FORCE INSERTION OF SAMPLE TUBE - An apparatus for holding a sample tube includes a plurality of rollers circumscribing a clearance space along a central axis, and an actuator configured for moving the rollers between a non-gripping position and a gripping position. At the non-gripping position, the rollers are oriented relative to the central axis such that a diameter of the clearance space is at a maximum; and at the gripping position, the rollers are at a twisted angle relative to the central axis, and the diameter is reduced such that the rollers contact the sample tube. | 09-11-2014 |
20140247187 | ESTIMATION OF TIME DIFFERENCE OF ARRIVAL (TDOA) IN MULTIPATH ENVIRONMENTS BASED ON SUB-NYQUIST RATE SAMPLING - A method is provided for to determining a time difference of arrival (TDOA) between a first signal and a second signal. The method includes sampling a first signal at a sub-Nyquist rate to provide a first sampled signal; sampling a second signal at the sub-Nyquist rate to provide a second sampled signal, the first and second signals representing corresponding multipath channels; cross-correlating the first and second sampled signals; and determining an estimate of the TDOA between the first and second signals based on the sampled first and second signals. | 09-04-2014 |
20140245168 | Graphical User Interface Editor that Displays Live Data During Editing - A method for operating a computer to develop a program having a GUI is disclosed. The method includes providing a program development system having an editing mode in which a user constructs a GUI and providing a graphical element that can be placed on a form as part of the GUI, the graphical element displaying data from the server while the program development system is in the editing mode. The parameters that control the connection and data transfer from the server can be provided in the properties section of the graphical element, and hence, no compilation of the underlying program is needed to verify the server connection and associated data. | 08-28-2014 |
20140240240 | Method for Selecting Waveforms on Electronic Test Equipment - A method for operating a data processing system having a touch enabled display screen that displays a plurality of waveforms to alter the display of one of the waveforms without altering the display of the remaining waveforms is disclosed. The method includes determining a selected waveform in response to a user touching the display screen in a first location thereby defining a touch area that determines the selected waveform. An operation that is to be performed on the selected waveform is then defined by a gesture on the screen. The selected waveform is determined by a touch area that is defined by the user touching the screen. If more than one waveform is defined by the touch area, the possible waveforms are sequentially selected until the correct one is presented to the user in response to the user repeating the touching that defines the touch area. | 08-28-2014 |
20140236539 | DIGITAL MEASUREMENT INSTRUMENT TRIGGERED BY SIGNAL PATTERN - A measurement instrument receives an analog input signal from a measurement target, converts the input signal into a digital signal, scans the digital signal and comparing the scanned digital signal with a pattern signature using a flexible matching procedure implemented by hardware, and triggers the measurement instrument according to a result of the flexible matching procedure. | 08-21-2014 |
20140230910 | SPLIT-CHANNEL GAS FLOW CONTROL - An apparatus comprises a proportional valve, a first channel connected to the proportional valve, a flow sensor connected to the first channel and configured to measure gas flow in the first channel, a split channel connected to the first channel at a location between the proportional valve and the flow sensor, and a control component connected between the flow sensor and the proportional valve and configured to control gas flow in the first channel. | 08-21-2014 |
20140219887 | APPARATUS AND METHODS FOR PIPETTING WITH INTERCHANGEABILITY AMONG DIFFERENT PIPETTE TIPS - Pipette tips of different sizes may be coupled to a pipettor without needing to modify the pipettor. The same pipettor may thus be utilized to exchange different pipette tips, which may be done in an automated manner. Pipette tips may be coupled to adaptors that include proximal ends for interfacing with the pipettor and distal ends for interfacing with pipette tips. The proximal ends may all have the same geometry, matched with the same pipettor. The distal ends may have different geometries matched with different pipette tips. A pipettor may be part of a liquid handling apparatus and movable in an automated manner to different deck positions. The pipettor may include a locking mechanism for locking adaptors to the pipettor or locking pipette tips directly to the pipettors, and an ejection mechanism for ejecting pipette tips from corresponding adaptors. | 08-07-2014 |
20140218025 | TRANSVERSE VOLUME COILS AND RELATED MAGNETIC RESONANCE SYSTEMS AND METHODS - A transverse volume magnetic resonance (MR) coil includes a cylindrical geometry of electrical conductors configured for generating a B | 08-07-2014 |
20140217276 | Sequential Low/High-Resolution Library Search - Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample. The systems and methods may further: (d) calculate exact masses for each of a plurality of candidate species; and (e) eliminate candidate species due to ions that are outside a mass error window. The mass error window may be less than 500 ppm. The system and methods presented may be used in, for example, gas chromatrography mass spectrum and/or liquid chromatography mass spectrometry systems. | 08-07-2014 |
20140215382 | Method for Utilizing Projected Gesture Completion to Improve Instrument Performance - A method of operating a first data processing system having a screen for responding to a vector gesture performed on that screen is disclosed. The method includes estimating a direction and assuming an identity for the vector gesture prior to the vector gesture being completed. A command that depends on the estimated direction and assumed identity is executed, the command being a command that would be required to update a current state of the first data processing system if the assumed identity of the vector gesture is correct. The command is executed prior to the vector gesture being completed. The current state of the first data processing system is then updated based on the data generated by the command. After the vector gesture has been determined to have been completed, the first data processing system is updated to a state indicated by the completed vector gesture. | 07-31-2014 |
20140215379 | Method for Automatically Adjusting the Magnification and Offset of a Display to View a Selected Feature - A method for operating a display in a data processing system to provide a view of a portion of a data array on a display screen is disclosed. The method includes providing a first display window characterized by a first offset, a first horizontal gain, and a first vertical gain and receiving a feature input from a user indicating a selected feature in the first display window. The data processing system automatically provides a second display window characterized by a second offset and a second horizontal gain and a second vertical gain. The second offset, the second horizontal gain and the second vertical gain are chosen such that the feature is at a predetermined location in the second display window and the second horizontal gain and second vertical gain are chosen such that the selected feature occupies a predetermined portion of the second display window. | 07-31-2014 |
20140212869 | Nucleic Acid Proximity Assay Involving the Formation of a Three-way junction - Provided herein is a proximity assay that, in certain embodiments, involves: (a) hybridizing a first oligonucleotide and a second oligonucleotide with a target nucleic acid, wherein the first oligonucleotide comprises: i. a region that is complementary to a first sequence in the target nucleic acid and ii. a barcode sequence; and the second oligonucleotide comprises i. a region that is complementary to a second region in the target and ii. the complement of the barcode sequence; and (b) detecting hybridization between the barcode sequence and the complement of the barcode sequence, wherein hybridization between the barcode sequence and the complement of the barcode sequence indicates that the first and second target sequences are proximal to one another in the sample. | 07-31-2014 |
20140207414 | REAL-TIME SPECTRUM ANALYZER INCLUDING FREQUENCY MASK GATE AND METHOD OF OPERATING THE SAME - A real-time spectrum analyzer for measuring time domain data sampled from an input signal includes a processing unit and a density histogram memory unit. The processing unit includes an FFT engine, a frequency mask detector and a frequency mask gate. The FFT engine performs FFTs on the sampled time domain data to provide FFT spectra, each FFT spectrum including multiple FFT points. The frequency mask detector determines whether each FFT point in each spectrum meets a trigger condition, and generates gate control signals corresponding to the FFT spectra based on the determinations. The frequency mask gate receives the FFT spectra and the gate control signals, and outputs only select FFT spectra that contain at least one FFT point that meets the trigger condition in response to the corresponding gate control signal. The density histogram memory unit stores the select FFT spectra for generating in a density histogram. | 07-24-2014 |
20140198549 | ENERGY DISSIPATING DEVICE FOR DC POWER SUPPLIES - An energy dissipating device configured to connect to a power supply and to dissipate excess energy from a direct current (DC) rail in response to a change in power supply settings or operating characteristics. The energy dissipating device is connected to the DC rail, which conducts current generated by an AC/DC converter to at least one DC/DC converter. When power demand to the DC/DC converter is reduced, the DC/DC converter generates a supplemental current surge on the DC rail. A rail current monitor monitors the current level on the DC rail and generates the DC rail power signal indicative of the supplemental current surge level generated by the at least one DC/DC converter. The supplemental surge current is used to control dissipative elements connected across the DC rail to modulate a current sink path across the DC rail to dissipate the excess energy from the DC rail. | 07-17-2014 |
20140195703 | ELECTRONIC SYSTEM SUBJECT TO MEMORY OVERFLOW CONDITION - A method of operating an electronic system comprises storing information corresponding to an input data stream in a first memory having a first operating rate, detecting an overflow condition of the first memory, generating overflow information in response to the detection of the overflow condition, storing the overflow information in a second memory having a second operating rate slower than the first operating rate, transferring the overflow information from the detector to a third memory at a first transfer rate corresponding to the first operating rate, temporarily storing the overflow information in the third memory, and transferring the stored overflow information to the second memory at a second transfer rate corresponding to the second operating rate, and combining the information stored in the first memory with the overflow information stored in the second memory to produce an output data stream. | 07-10-2014 |
20140190183 | EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP - Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (SFC) system is described. A system for chilling a pumping system, includes a Peltier cooling element in thermal contact with a pump head, wherein the cooling element chills the pump head and a mobile phase fluid flowstream prior to the mobile phase fluid entering the pump; a fluid-cooled heat exchanger, attached to the Peltier cooling element, which removes heat from the cooling element using a circulating fluid; and a second heat exchanger which cools the circulating fluid. | 07-10-2014 |
20140183137 | DRIFTING TWO-DIMENSIONAL SEPARATION WITH ADAPTION OF SECOND DIMENSION GRADIENT TO ACTUAL FIRST DIMENSION CONDITION - A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed. | 07-03-2014 |
20140175288 | INTERFEROMETER HAVING MULTIPLE SCAN CARRIAGES - An interferometer includes a fixed assembly including a base, a beam splitter assembly and a fixed mirror, and a movable assembly including an upper scan carriage, a lower scan carriage and a movable mirror connected to the lower scan carriage. The pair of inner bearing flexures is connected to the base and the upper scan carriage, enabling movement of the upper scan carriage relative to the base, and the pair of outer bearing flexures is connected to the upper and lower scan carriages, enabling movement of the lower scan carriage relative to the upper scan carriage. The movement of the upper and lower scan carriages enable a scan movement of the movable mirror in a scan direction restricted such that the scan movement maintains a plane containing the movable mirror parallel to planes containing the movable mirror at respective distances between the movable and fixed assemblies during the scan movement. | 06-26-2014 |
20140167612 | Vacuum Ultraviolet Photon Source, Ionization Apparatus, and Related Methods - A vacuum ultraviolet (VUV) photon source includes a body, a VUV window, electrodes disposed on the body outside an interior thereof, and a dielectric barrier between the electrodes. A method for generating VUV photons includes generating a dielectric barrier discharge (DBD) in an interior of a photon source by applying a periodic voltage between a first electrode and a second electrode separated by a dielectric barrier, wherein the DBD produces excimers from a gas in a gap between the electrodes, and transmitting VUV photons through a window of the photon source. | 06-19-2014 |
20140152335 | CONTINUOUS BROKEN SENSE LEAD DETECTION SYSTEM - Disclosed is a continuous broken sense lead detection system (“CBSLDS”) for use with a Kelvin-connected device under test (“DUT”), a power source, and detection system stimulus configured to provide a periodic stimulus voltage. The CBSLDS is configured to detect a discontinuity in a first sense lead, second sense lead, or both, that are in signal communication with the DUT. The CBSLDS includes a first transformer, second transformer, first DC-blocker, second DC-blocker, first detection module, and second detection module. | 06-05-2014 |
20140151546 | MULTI-CAPILLARY COLUMN AND HIGH-CAPACITY IONIZATION INTERFACE FOR GC-MS - A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging. | 06-05-2014 |
20140150139 | METHOD OF CONTROLLING FREQUENCY MODULATED-ATOMIC FORCE MICROSCOPE - A method is provided for controlling an FM-AFM including a cantilever having a resonant frequency and an excitation system configured to oscillate the cantilever in response to a drive signal. The method includes determining latency of the excitation system; receiving a deflection signal indicating a deflection of a cantilever tip; mixing the deflection signal with a first sine signal output by a PLL indicating a frequency shift of a frequency response of the cantilever; measuring the frequency shift in response to the drive signal; determining spurious phase of the cantilever based on the determined latency, the resonant frequency of the cantilever, and the measured frequency shift; providing a second sine signal having a phase that is advanced by the determined spurious phase to preemptively compensate for subsequent spurious phase of the cantilever; and driving the excitation system using the second sine signal with an adjusted amplitude as the drive signal. | 05-29-2014 |
20140138526 | TIME OF FLIGHT MASS SPECTROMETER - A method of determining the mass-to-charge ratios of ions in a sample is disclosed. The method includes determining a data acquisition time, where the data acquisition time is a predetermined fraction of the greatest time of flight. The method also includes providing ions from a continuous beam of a sample to a time-of-flight mass analyzer at pulse intervals having a duration equal to the predetermined fraction of the greatest flight time. The method also includes measuring a peak width and a flight time value for each of the ion species in the sample after summing the data acquired during several pulse intervals and correcting the measured flight time values according to a correlation of measured peak width values with calibration data of peak width versus flight time. | 05-22-2014 |
20140137300 | ATOMIC FORCE MICROSCOPE SYSTEM USING SELECTIVE ACTIVE DAMPING - An atomic force microscope (AFM) system comprises a cantilever arm attached to a probe tip. The system controls a height of the cantilever arm to press the probe tip against a sample and then separate the probe tip from the sample, to detect a disturbance of the cantilever arm after the separation of the probe tip from the surface, and to engage active damping of the cantilever arm to suppress the disturbance. | 05-15-2014 |
20140137088 | Method for Enforcing Language Subsets - A method of operating a data processing system to examine a compiled program for violations of a set of rules that do not constitute violations detected by the compiler that generated the program. The method includes obtaining a restricted rule set defined in terms of rules in a decompiled representation of the program. The method also includes decompiling the compiled program to the decompiled representation of the compiled program in which the restricted rule set is defined, examining the decompiled representation of the compiled program for a violation of the restricted rule set to determine if any of the rules are violated, and providing an output indicating that one of the rules was violated. | 05-15-2014 |
20140122696 | Method for Monitoring and Displaying High Speed Bus Performance - A method for operating a data processing system to display data related to a plurality of packets that traverse a communication link is disclosed. A copy of the packets that traverse the link is provided including a timestamp corresponding to each packet that defines a time at which the packet traversed the link. A display is generated having first and second regions. The first region includes an X-Y chart in which each packet is represented by a multi-value glyph denoting a first property related to that packet, the first property having more than two values. The second region includes a first annotation glyph for one of the packets, the first annotation glyph being located at the X-location corresponding to the timestamp for the packet. The first annotation glyph is present if that data packet has a second property. | 05-01-2014 |
20140122025 | METHOD AND SYSTEM FOR PERFORMING REAL-TIME SPECTRAL ANALYSIS OF NON-STATIONARY SIGNAL - A method is provided for performing real-time spectral analysis of a non-stationary signal. The method includes sampling the non-stationary signal, using an observation window having a length short enough to approximate a stationary signal, to provide an initial set of sampled data, buffering the initial set of sampled data to obtain multiple buffered sets of sampled data, filtering the initial set of sampled data and the buffered sets of sampled data, using corresponding filter responses, to obtain multiple filtered sets of sampled data, and performing a chirp-z-transform (CZT) of the filtered sets of sampled data to provide a set of discrete Fourier transforms (DFT) coefficients. A total signal spectrum of the non-stationary signal is reconstructed using the set of DFT coefficients. | 05-01-2014 |
20140119993 | CHEMILUMINESCENT DETECTOR HAVING COATING TO REDUCE EXCITED SPECIES ADSORPTION - An apparatus for receiving a chemical species is disclosed. The apparatus includes an emission block configured to receive a vapor phase chemical species that is excited by chemical reaction in the emission block to provide an excited species that emits hot. The emission block has an interior portion having a surface. A coating is disposed over the surface and the coating reduces adsorption of the excited species onto the surface. | 05-01-2014 |
20140118742 | FLAME PHOTOMETRIC DETECTOR - A flame photometric detector (FPD) for use in a gas chromatography (GC) apparatus is described. The FPD has an emission block that is maintained in a first temperature range, and a transfer line that is maintained in a second temperature range that is greater than the first temperature range. The FPD is coupled to a light detector, such as a photomultiplier tube (PMT). | 05-01-2014 |
20140118082 | FORWARD COUPLED DIRECTIONAL COUPLER - Described is a directional coupler for forward coupling energy from an input port to a coupling port. The directional coupler has a coupling factor and an operating frequency and an operating wavelength corresponding to the operating frequency. | 05-01-2014 |
20140117970 | Voltage-Current Characteristic Generator - Disclosed is a voltage-current characteristic generator that includes: a voltage source; a current source; a selector for selecting and outputting the output of either the voltage source or the current source; a sensing portion, connected to an output of the selector, for outputting the output of the selector and for sensing, and feeding back, the voltage and current of the output; and a controller for receiving the voltage and current detected by the sensing portion and for setting the subsequent outputs in the voltage source and the current source, wherein, in addition to setting the subsequent outputs, the controller evaluates an operating mode wherein the subsequent output from the selector is to be from either the voltage source or the current source. | 05-01-2014 |
20140116159 | SAMPLE INJECTOR WITH DISCONNECTABLE INJECTION NEEDLE - A sample injector ( | 05-01-2014 |
20140111804 | Heterodyne Optical Spectrum Analyzer - A heterodyne optical spectrum analyzer ( | 04-24-2014 |
20140110574 | TRANSIENT LEVEL DATA ACQUISITION AND PEAK CORRECTION FOR TIME-OF-FLIGHT MASS SPECTROMETRY - Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement transient-level data acquisition and peak correction in a time-of-flight mass spectrometer. Transient spectra including analyte peaks and reference mass peaks are recorded, from which a set of averaged peak centroids of the reference masses is generated. The peaks of reference masses in each transient spectrum are compared to the averaged peak centroids. From this comparison, an appropriate correction function is applied to each transient spectrum to correct the positions of the analyte peaks in each transient spectrum. The corrected transient spectra are then summed to obtain a corrected averaged spectrum. | 04-24-2014 |
20140095082 | EXPANDED LINEAR RANGE BY USE OF TWO FLOW CELL DETECTORS WITH LONG AND SHORT PATH - A sample detection apparatus ( | 04-03-2014 |
20140093916 | IMMOBILIZED TRANSPOSASE COMPLEXES FOR DNA FRAGMENTATION AND TAGGING - The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a specific binding pair, in which one member of the pair is bound to an oligonucleotide adapter of the complex and the other member of the pair is bound to a solid substrate. The bound complexes can be immediately used in DNA fragmentation reactions to produce solid substrate-bound DNA fragments, which can be used for any number of purposes, including as templates for amplification and sequencing. | 04-03-2014 |
20140091422 | Thin Film with Improved Temperature Range - A device and a method of forming the same are disclosed. The device comprises a substrate and a thin film. The substrate is characterized by a first coefficient of thermal expansion. The thin film is attached to a surface of the substrate, and is characterized by a second coefficient of thermal expansion. The thin film includes first and second layers in states of compression, and a third layer in a state of tension, the third layer being positioned between the first and second layers. The thin film is in a net state of tension within a temperature range. | 04-03-2014 |
20140086499 | DYNAMIC CREATION OF TREND GRAPH - A method of generating a trend graph comprises storing a stream of data elements in a buffer having a storage capacity corresponding to a first number of data elements, compressing the stored data elements to fit within a display having a size corresponding to a second number of data elements smaller than the first number of data elements, detecting an event, and as a consequence detecting the event, compressing the stored data elements to occupy a reduced portion of the buffer. | 03-27-2014 |
20140085116 | THREE-FREQUENCY PHASE DIGITIZING SYSTEM AND METHOD OF THREE-PHASE DIGITIZING AN INTERFEROMETER SIGNAL USING THE SAME - A phase digitizing system includes an analog-to-digital converter (ADC), multiple phase accumulators and a processing device. The ADC generates sample segments of digital signal waveform samples based on an analog composite input signal received in a measurement channel, the composite input signal includes a first signal having a first frequency F1 and a second signal imported from a reference channel having a second frequency F2. The processing device is coupled to the phase accumulators, and digitally processes each sample segment with outputs of the phase accumulators, and continually generates digital phase data The processing device further provides increment values to each of the phase accumulators based on the digital phase data, causing an output of a first phase accumulator to represent an instantaneous phase of the first signal, and an output of a second phase accumulator to represent an instantaneous phase of the second signal. | 03-27-2014 |
20140084156 | RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS AT HIGH PRESSURE - Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system. | 03-27-2014 |
20140083946 | HYDROLYTICALLY STABLE ION-EXCHANGE STATIONARY PHASES AND USES THEREOF - The invention provides novel ion-exchange media and related methods for their preparation and use. Ion-exchange stationary phases according to the invention are suitable for chromatographic separation of a variety of biomolecules. Distinguishing characteristics of ion-exchange media according to this invention includes, for example, their ability to separate variants of monoclonal antibodies via cation-exchange liquid chromatography using porous substrates with particle sizes <5 μm. The ion-exchange stationary media include a hydrolytically stable layer, which inhibits surface degradation of the particles in 100% aqueous media. Another unique feature is low molecular weight building blocks used to functionalize the particles with ion-exchange groups. | 03-27-2014 |
20140060331 | INTEGRATED PARTICLE TRAP FOR CAPILLARY PLOT COLUMNS - A porous layer open tubular (PLOT) column includes capillary tubing; one or two particle traps disposed inside one or two end sections of the capillary tubing; and a stationary phase comprising a porous or non-porous material coated inside a main section of the capillary tubing. A method for preparing a porous layer open tubular (PLOT) column includes preparing one or two particle traps inside one or two end sections of a capillary tubing; and preparing a stationary phase comprising a layer of a porous material coated inside a main section of the capillary. | 03-06-2014 |
20140034827 | SYSTEMS AND METHODS FOR MS-MS-ANALYSIS - A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer. | 02-06-2014 |
20140034825 | ADJUSTING ENERGY OF IONS EJECTED FROM ION TRAP - An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied. | 02-06-2014 |
20140030732 | MICROFLUIDIC HPLC-CHIP FOR GLYCOPEPTIDE ANALYSIS WITH INTEGRATED HILIC ENRICHMENT - A microfluidic device for glycopeptide analysis includes an enrichment column capable of binding carbohydrates; a trapping column capable of binding peptides, wherein the trapping column is configured to be connected downstream of the enrichment column; a separation column, wherein the separation column is configured to be connected downstream of the trapping column; and a plurality of ports configured to work with a switching device to form a plurality of flow paths, wherein one of the plurality of flow paths allows the trapping column to be in fluid communication with the separation column. A method for glycopeptide analysis using a microfluidic device comprising a trapping column and a separation column, the method includes applying a sample of peptides to the microfluidic device; trapping the peptides on the trapping column; eluting the peptides from the trapping column into the separation column; and separating the peptides on the separation column. | 01-30-2014 |
20140002097 | PASSIVE INTERMODULATION MEASUREMENT APPARATUS | 01-02-2014 |
20130341260 | SEALED FLUIDIC COMPONENT COMPRISING A COMPOSITE MATERIAL OF DIFFERENT PAEK MATERIALS - A sealed fluidic component ( | 12-26-2013 |
20130338932 | COMPUTATIONAL METHOD FOR MAPPING PEPTIDES TO PROTEINS USING SEQUENCING DATA - A method for proteomic analysis of a biological sample is disclosed, which includes obtaining peptide sequences of proteins in a target list; and identifying proteins in the biological sample by mapping the obtained peptide sequences on proteins in a proteomic database, wherein the target list is determined using information of RNA transcripts in the biological sample and/or the target list is determined using information of RNA transcripts in the biological sample. The peptide sequences are determined using a mass spectrometer. The mapping is performed on a subset of proteins based on the information of RNA transcripts. | 12-19-2013 |
20130335130 | APPARATUS AND METHOD FOR PROVIDING TIMING ADJUSTMENT OF INPUT SIGNAL - An apparatus for providing time adjustment of an input signal includes a coarse timing digital-to-analog converter (DAC), a replica delay element and an interpolator. The coarse timing DAC has multiple delay settings for providing a coarse timing adjustment of the input signal, and outputs a first delayed signal by delaying the input signal by a first delay time corresponding to a selected setting of the multiple delay settings. The replica delay element receives the first delayed signal from the coarse timing DAC and outputs a second delayed signal by delaying the first delayed signal by a predetermined second delay time. The interpolator blends either the input signal and the first delayed signal or the first delayed signal and the second delayed signal for providing a fine timing adjustment of the input signal, and outputs a timing adjusted output signal including the coarse timing adjustment and the fine timing adjustment. | 12-19-2013 |
20130333076 | ATOMIC FORCE MICROSCOPY CONTROLLER AND METHOD - A method for determining a loop response for an apparatus for an atomic force microscope is disclosed. The method comprises: determining a loop response for an on-surface movement of a cantilever over a frequency range; determining a loop response for an off-surface movement of the cantilever over the frequency range; and adjusting an output of the controller at a frequency based on the loop response for the off-surface movement. An atomic force microscopy system is disclosed. | 12-12-2013 |
20130323725 | TARGET ENRICHMENT AND LABELING FOR MULTI-KILOBASE DNA - This disclosure provides a method comprising: a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked; b) denaturing the duplex to produce a denatured product; and c) renaturing the denatured product in the presence of a labeled oligonucleotide that is complementary to a sequence of nucleotides in the double stranded DNA molecule, thereby producing a D-loop-containing product. Kits for performing the method and products made by the method are also provided. | 12-05-2013 |
20130322570 | PHASE NOISE EXTRACTION APPARATUS AND TECHNIQUE - A phase noise extraction apparatus and technique that extracts phase noise induced by a component of a transmitter from a radio frequency (RF) signal and attenuates noise induced from other sources. The RF signal is digitized, modulation is removed, and the carrier is suppressed to provide a noise signal including the phase noise and the noise induced from the other sources. A complementary autocorrelation operation is applied to the noise signal to attenuate the noise from the other sources. The correlated signal is transformed into the frequency domain to generate a power spectrum of the phase noise that may be measured or displayed. | 12-05-2013 |
20130320959 | Power Device Analyzer - A device analyzer for analyzing power devices. An example device analyzer comprises a collector supply to generate supply signal pulses with selected voltage or current levels and a supply signal pulse width at a high current. The supply signal pulses are applied at a collector supply source terminal when DUT is connected to conduct current between the collector supply source terminal and a collector supply common terminal. A supply switch closes or opens the DUT current path in narrow pulses having a narrow pulse width narrower than the supply signal pulses to conduct the supply signal pulses as narrowed sweep signal pulses having the high current capacity of the collector supply current. The supply switch alternatively regulates the current in the current path at constant current levels. Other modules capable of high power test capabilities may also be added. | 12-05-2013 |
20130314071 | TRANSFORMER CORRECTION CIRCUIT AND TECHNIQUE FOR REDUCING CROSS-TALK CURRENT - An apparatus and technique that reduces induced cross-talk current between transformer windings. The apparatus includes a transformer having a first secondary winding that provides a first voltage relative to earth ground, a second secondary winding that provides a second voltage relative to floating ground, and a shield disposed between the first and second secondary windings. A correction circuit connected to the first secondary winding is configured to generate a correction voltage. The correction voltage drives a shield to induce a correction current into the second secondary winding to reduce cross-talk current induced between the first and second secondary windings. | 11-28-2013 |
20130312499 | PRESSURIZABLE INJECTION SEAT - An injection device ( | 11-28-2013 |
20130298647 | FITTING ELEMENT WITH BIO-COMPATIBLE SEALING - A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing, and the receiving cavity having a receiving contact surface of a bio-compatible material. The fitting element includes a first sealing element of a bio-compatible material configured for sealing to the bio-compatible material of the inner contact surface of the tubing, and a second sealing element configured for sealing against a pressure ambient to a pressure of the fluid in the tubing. Upon coupling of the tubing to the fluidic device, at least a portion of the receiving contact surface, the first sealing element, and the second sealing element enclose an interspace, each surface of the interspace being a bio-compatible material. | 11-14-2013 |
20130286390 | OPTICAL EMISSION SYSTEM INCLUDING DICHROIC BEAM COMBINER - An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second light into the entrance aperture, enabling analysis and measurement of both first and second light characteristics simultaneously. The portion of the first light reflected into the entrance aperture predominately has wavelengths in a first range of wavelengths and the portion of the second light transmitted into the entrance aperture predominately has wavelengths in a second range of wavelengths, different from the first range of wavelengths. | 10-31-2013 |
20130280145 | LIQUID HANDLER WITH DUAL PIPETTING GROUPS - An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group. | 10-24-2013 |
20130258343 | METHOD AND APPARATUS TO IMPROVE SIGNAL-TO-NOISE RATIO OF FT-IR SPECTROMETERS USING PULSED LIGHT SOURCE - An optical spectroscopy method and apparatus increases signal to noise ratio of detected signals. Sample light passed through a sample includes attenuated light pulses and characteristic light located between the attenuated light pulses, the characteristic light formed by interaction between light pulses incident the sample and sample molecules. The attenuated light pulses are substantially removed from the sample light emerging from the sample prior to detection, to increase signal to noise ratio of the detected signal. | 10-03-2013 |
20130252272 | Method and Apparatus for Tracking the Motion of Molecules in a Microscope - An apparatus and method for measuring the mobility of molecules in a sample are disclosed. Molecules in a sample are tagged with a dye having active and inactive states that are generated by exposing dye to light of an activation wavelength and an inactivation wavelength, respectively, the activation wavelength being different from the inactivation wavelength. The sample is illuminated in a microscope with a light pattern that includes a first region in which the dye is activated and a second adjacent region in which the first dye is inactivated. After the sample is so illuminated, an image of the activated first molecules is recorded when the first molecules are illuminated with light of an excitation wavelength. Molecules having the first dye in the inactive state are distinguishable from molecules having the first dye in the active state in the microscope when illuminated with light of the excitation wavelength. | 09-26-2013 |
20130249637 | MULTI-PATH BROADBAND AMPLIFIER - An amplifier device having an extended bandwidth includes a DC coupled amplifier and multiple low noise amplifiers connected in series with one another and connected in parallel with at least a portion of the DC coupled amplifier. The DC coupled amplifier has a broad bandwidth, and each of the low noise amplifiers has a narrow bandwidth and a center frequency higher than a high end frequency of the broad bandwidth of the DC coupled amplifier. The extended bandwidth of the amplifier device is a combination of the broad bandwidth and the first narrow bandwidth. | 09-26-2013 |
20130229747 | BALANCED VOLTAGE VARIABLE CAPACITOR DEVICE - A variable capacitor device includes a stator and a rotor. The stator includes first and second stator plates separated by electrically insulating material. The rotor includes first and second rotor plates connected by a rod, the rotor being configured to move axially for adjusting alignment of the first rotor plate relative to the first stator plate and the second rotor plate relative to the second stator plate, respectively. The first stator plate and the first rotor plate form a first variable capacitor, and the second stator plate and the second rotor plate form a second variable capacitor connected in series with the first variable capacitor. A first capacitance of the first variable capacitor and a second capacitance of the second variable capacitor are simultaneously adjustable upon the axial movement of the rotor to provide an adjustable total capacitance of the variable capacitor device. | 09-05-2013 |
20130225429 | Method of Determining Thermodynamic and Kinetic Parameters from Measured Off Rates - A method for measuring a property of a binding interaction between a capture agent and a binding partner for the capture agent is provided. In certain embodiments, this method comprises: a) contacting a population of particles that are linked to a capture agent with a substrate comprising a binding partner to produce capture agent/binding partner complexes, wherein the population of particles comprises first particles that are bound to a single molecule of the capture agent and second particles that are bound to two molecules of the capture agent; b) applying a force to the bound support, wherein the force is in a direction that separates the particles from the support; and c) separately measuring the forces required to disassociate the first particles and the second particles from their respective complexes. | 08-29-2013 |
20130225110 | DOWNCONVERSION OF COMB SPECTRUM - A downconverter mixes a first comb spectrum with a local oscillator signal to generate a second comb spectrum in a lower frequency range. The first comb spectrum comprises frequency components separated from each other according to a frequency spacing interval, and the LO signal has a frequency offset relative to the first comb spectrum, where the frequency offset is a rational fraction of the frequency spacing interval. The second comb spectrum comprises lower and upper sideband responses corresponding to respective lower and upper sideband signals of the first comb spectrum. The lower and upper sideband responses in the second comb spectrum can be distinguished from each other based on the frequency offset. | 08-29-2013 |
20130207641 | DIGITAL OSCILLOSCOPE COMPRISING MULTIPLE DATA ACQUISITION PATHWAYS - A digital oscilloscope comprises a sampling unit configured to sample an input signal received from an oscilloscope probe to produce a first stream of digital samples, a first acquisition system configured to store and process the stream of digital samples to produce a first data set, a second acquisition system configured to store and process the first stream of digital samples independent of the first acquisition system to produce a second data set, and a display system configured to concurrently display the first data set in a first format and the second data set in a second format different from the first format. | 08-15-2013 |
20130202020 | METHOD OF GENERATING INTERFERENCE SIGNALS AND DEVICE TO CARRY OUT SUCH A METHOD - A method for generating interference signals and a device to carry out said method, in which an interference signal ( | 08-08-2013 |
20130200751 | CHARGE CORRECTION FOR PIEZOELECTRIC ACTUATOR - A system comprises a voltage source, a piezoelectric material arranged in a first current path between the voltage source and a first reference voltage, a capacitor arranged in a second current path between the voltage source and a second reference voltage, and a correction circuit configured to adjust the first reference voltage to increase or decrease the current in the first current path according to the current in the second current path. | 08-08-2013 |
20130199981 | FERRULE CHUCK WITH SURFACE MICRO-GRIP - A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule. | 08-08-2013 |
20130197848 | SYSTEM FOR MEASURING RESIDUAL PHASE NOISE - A system for measuring residual phase noise of a device under test (DUT) includes first and second signal sources, first and second receivers, and a processor. The first signal source generates a first signal to be input to the DUT as a stimulus signal and provides a second signal that is phase coherent with the first signal. The second signal source receives the second signal and generates a reference signal based on the second signal, which is phase coherent with the stimulus signal. The first receiver measures an output signal from the DUT responsive to the stimulus signal, and the second receiver measures the reference signal from the second signal source. The processor mathematically suppresses a carrier of the output signal by determining a difference between the measured output signal and the measured reference signal, and determines the residual phase noise of the DUT based on the difference. | 08-01-2013 |
20130195129 | PHASE-CONTINUOUS TUNABLE LASER - A tunable laser comprises a first tuner configured to select an emission wavelength of the laser a second tuner configured to adjust a cavity mode of the laser by modifying the cavity optical path length. The second tuner is constrained by a finite tuning range. The tunable laser also comprises a controller configured to control the first and second tuners to select the emission wavelength and adjust the cavity mode in synchronization to perform phase-continuous tuning across a range larger than supported by the finite tuning range of the second tuner. | 08-01-2013 |
20130194160 | COMPACT, ULTRA-BROADBAND ANTENNA WITH DOUGHNUT-LIKE RADIATION PATTERN - A compact, ultra-broadband antenna with doughnut-like radiation pattern is provided as including a first assembly having first and second ends; a second assembly having first and second ends, the first and second ends each configured to have a substantially hemispherical shape; and a cable configured to extend through the first and second assemblies and out each of the first and second ends. | 08-01-2013 |
20130193318 | ION SOURCE FOR MASS SPECTROMETERS - Ion sources for use in mass spectrometry (MS) systems are described. The ion sources each comprise an ion funnel and an ionization source configured to ionize neutral analyte molecules. | 08-01-2013 |
20130192698 | LOW NOISE BACK PRESSURE REGULATOR FOR SUPERCRITICAL FLUID CHROMATOGRAPHY - A drive mechanism for back pressure regulator used in liquid chromatography, supercritical fluid chromatography, or supercritical fluid extraction allows very fine automated control over a very wide range of pressures by combining a linear actuator compressing a spring, pushing a pin. The nozzle assembly of the regulator comprises a flow through chamber containing a diaphragm and a seat, in which the pin pushes the diaphragm against the seat, together with an upstream pressure sensor and electronic feedback control to the motor of the actuator. The BPR of the embodiments exhibits high pressure stability and extremely low pressure noise, even at moderate to high pressures. The exemplary BPR can be use at either constant pressure or to generate pressure programs where the pressure is varied versus time. Further, the nozzle assembly has a field-replaceable head, requiring no mechanical adjustment on replacement. | 08-01-2013 |
20130180404 | SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS - An apparatus and process to effectively create an active drain for high and low pressure gas-liquid separator. The invention accomplishes a deterministic drainage rate of variable volume and viscosity liquid fractions from the separator. The mechanisms and methods thereof create a flow path from the separator that dramatically favors controlled liquid flow over a wide range of flow rates and viscosities while restricting gas flow. The invention is a superior method of drainage over conventional systems that employ pressure, vacuum, isolation valves and/or passive flow restrictors to achieve drainage of the separators. The embodiments are primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE). An advantage of one embodiment allows the economical conversion of typical HPLC systems to state of-the-art supercritical fluid chromatography (SFC) systems with minimal modification to system components. | 07-18-2013 |
20130178366 | NUCLEAR MAGNETIC RESONANCE PROBE COMPRISING INFRARED REFLECTION PATCHES - A nuclear magnetic resonance (NMR) probe comprises a substrate, a probe coil formed on the substrate and comprising a superconducting material, and a plurality of infrared (IR) reflection patches formed on the substrate around the probe coil. | 07-11-2013 |
20130175442 | INDUCTIVELY COUPLED PLASMA MS/MS MASS ANALYZER - An inductively coupled plasma MS/MS mass analyzer (ICP-MS/MS) may include a first vacuum chamber which draws plasma containing an ionized sample into vacuum, a second vacuum chamber which includes a device or means which extracts and guides ions as an ion beam from the ions output from the first vacuum chamber, a third vacuum chamber which has a first ion optical separation device or means, a fourth vacuum chamber which has a cell into which reaction gas is introduced, and a fifth vacuum chamber which has a second optical separation device or means and a detector, wherein the second vacuum chamber and third vacuum chamber are individually evacuated. | 07-11-2013 |
20130175440 | RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS - Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. | 07-11-2013 |
20130170843 | OPTICAL COHERENT RECEIVER WITH LOCAL OSCILLATOR LASER HAVING HYBRID CAVITY - A coherent optical receiver includes a local oscillator (LO) laser configured to provide an LO signal. The LO laser includes a hybrid external cavity and an active gain medium within the hybrid external cavity, where the LO laser is defined between a first optical reflector on a chip including the active gain medium and a second optical reflector not on the chip. | 07-04-2013 |
20130169341 | DETECTING RESPONSES OF MICRO-ELECTROMECHANICAL SYSTEM (MEMS) RESONATOR DEVICE - A system for detecting responses of a MEMS resonator device includes first and second signal sources, a signal divider and a frequency mixer. The first signal source provides a first signal and the second signal source provides a second signal that electrostatically drives the MEMS resonator device, causing mechanical vibration. The signal divider divides the first signal into a probe signal and a local oscillator (LO) signal, the probe signal being applied to the MEMS resonator device and reflected by a capacitance of the MEMS resonator device. A reflection coefficient is modulated onto the reflected probe signal at the mechanical resonance frequency by variations in the capacitance induced by the mechanical vibration of the MEMS resonator device. The frequency mixer mixes the reflected probe signal and the LO signal and outputs an intermediate frequency (IF) signal, which represents modulation of the reflection coefficient, providing an image of the mechanical vibration. | 07-04-2013 |
20130161517 | ADJUSTABLE APERTURE DEVICE WITH INTEGRAL APERTURE HOLES - An adjustable aperture device for an electromagnetic radiation detecting apparatus includes a position adjustment body configured for adjusting a position of a selected aperture hole of multiple selectable aperture holes, where electromagnetic radiation propagates through the selected aperture hole. The adjustable aperture device further includes a guide unit configured for guiding the position adjustment body along a predefined guide direction, and an aperture body defining the aperture holes and including multiple engagement sections, where the adjustment body is engagable in a selectable one of the engagement sections to thereby select the selected aperture hole. The adjustable aperture device further includes a pre-loading element configured for pre-loading the position adjustment body towards the aperture body, and a drive unit configured for driving the aperture body to move so that the position adjustment body is engaged in a respective one of the plurality of engagement sections. | 06-27-2013 |
20130161506 | DATA ACQUISITION MODES FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY - Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition. | 06-27-2013 |
20130138416 | METHOD FOR PREDISTORTING SIGNALS FOR NON-LINEAR COMPONENTS IN THE PRESENCE OF LONG TERM MEMORY EFFECTS - A method and system for predistorting signals provides a test signal to model a non-linear component. Model kernels representative of static and dynamic parts of the model are extracted from an output of the non-linear component responsive to the test signal. The dynamic part represents memory effects of the non-linear component. The model kernels are then used to calculate an inverse memory model component model. An input signal is predistorted using the inverse memory model. | 05-30-2013 |
20130137861 | NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS - A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: | 05-30-2013 |
20130137582 | QUANTITATIVE PCR-BASED METHOD TO PREDICT THE EFFICIENCY OF TARGET ENRICHMENT FOR NEXT-GENERATION SEQUENCING USING REPETITIVE DNA ELEMENTS (LINES/SINES) AS NEGATIVE CONTROLS - A method for determining an efficiency of target enrichment from a DNA library, includes: adding a negative control sequence and a positive control sequence to the DNA library, or picking a negative control sequence and/or a positive control sequence from the library; determining a pre-capture amount of the negative control sequence and a pre-capture amount of the positive control sequence; performing enrichment of a target sequence from the DNA library using a bait sequence to produce a post-capture library; determining a post-capture amount of the negative control sequence and a post-capture amount of the positive control sequence in the post-capture library; and determining the efficiency of the target enrichment, based on the post-capture amount of the positive control sequence, the post-capture amount of the negative control sequence, the pre-capture amount of the positive control sequence, and the pre-capture amount of the negative control sequence. | 05-30-2013 |
20130134095 | TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY WITH CONTROL OF INJECTION IN RELATION TO A STATE OF THE SECOND DIMENSION CHROMATOGRAPH - A two-dimensional liquid chromatography in a system ( | 05-30-2013 |
20130134082 | FITTING ELEMENT WITH HYDRAULIC GRIP FORCE ELEMENT - A fitting element ( | 05-30-2013 |
20130127324 | PLASMA TORCH WITH MULTIPLE INLETS FOR GUIDING COOLING GAS - A plasma torch comprises: a glass inner tube comprising an outlet where a plasma is formed; a glass outer tube comprising at least three inlets for receiving a cooling gas and distributing the cooling gas between the glass outer tube and the glass inner tube; and a cartridge housing comprising a gas receiving inlet, the glass outer tube being in fluid communication with the gas receiving inlet. Any two of the at least three inlets are radially offset by fewer than 180°. | 05-23-2013 |
20130123129 | USE OF DNAZYMES FOR ANALYSIS OF AN RNA SAMPLE - Provided herein is method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in the initial sample, thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage. | 05-16-2013 |
20130122550 | MULTI-SITE MUTAGENESIS - The present invention provides compositions and improved methods for multi-site directed mutagenesis and DNA shuffling. The present compositions and methods provide increased mutation frequency and increased number of transformants which allow one to sequence only a few clones in order to identify the correct mutants and to obtain the desired mutant by screening large number of transformants in a short time. Moreover, the inclusion of FEN-1, PEF and optimized buffer and cycling conditions provided in the present invention should also facilitate random mutagenized library construction and the mutagenesis of large or difficult templates. | 05-16-2013 |
20130115714 | WESTERN BLOT ANALYTICAL TECHNIQUE - In accordance with an embodiment of the present invention, there is provided a method of performing the western blot analytical technique, wherein the method comprises carrying out the following steps in the following order: a), pre-staining the proteins within a sample; b). separating the proteins using gel electrophoresis; c). analysing the separated proteins to determine the total protein load and/or at least one housekeeping protein load; d). transferring the proteins onto at least one membrane; e). probing the separated proteins to detect a target protein; and f). analysing the probed proteins to determine the target protein's molecular weight and/or load. | 05-09-2013 |
20130110442 | CALIBRATING RECONSTRUCTED SIGNAL USING MULTI-TONE CALIBRATION SIGNAL | 05-02-2013 |
20130110262 | AUTOMATIC TUNING OF ATOMIC FORCE MICROSCOPE | 05-02-2013 |
20130106401 | OSCILLOSCOPE PROBE COMPRISING STATUS INDICATOR | 05-02-2013 |
20130102459 | Inorganic/Organic Hybrid Totally Porous Metal Oxide Particles, Methods For Making Them And Separation Devices Using Them - The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation. | 04-25-2013 |
20130099113 | IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS - In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. | 04-25-2013 |
20130082854 | REDUCING METASTABILITY IN ANALOG TO DIGITAL CONVERSION - A system for performing analog-to-digital conversion comprises a sampling unit that generates multiple digital samples from an analog input signal at each recurrence of a periodic interval, and a processing unit that combines the digital samples to produce a digital output signal. In certain embodiments, the sampling unit comprises multiple analog-to-digital converters arranged in parallel, and the processing unit comprises a digital signal processor that detects outliers in the digital samples and averages any non-outliers among the digital samples to generate the digital output signal. | 04-04-2013 |
20130082709 | PARALLEL MAGNETIC RESONANCE IMAGING USING GLOBAL VOLUME ARRAY COIL - A magnetic resonance imaging (MRI) apparatus comprises a plurality of cylindrical electromagnetic coils arranged in a coaxial configuration around a sample region. The coils are used to capture resonance signals from a sample at different times according to a geometric echo effect. The measurements can then be combined to produce an MRI signal. | 04-04-2013 |
20130082695 | CLOSED CORE CURRENT PROBE - A current probe enabling measurement of current of a signal in a circuit includes a ferrite core defining a gap, a wire wrapped around the ferrite core and a magnetic field sensor. The wire is configured to receive the signal from the circuit, where the current of the signal flowing in the wire generates a magnetic field in the ferrite core. The magnetic field sensor is positioned in the gap of the ferrite core, the magnetic field generated in the ferrite core flowing through the magnetic field sensor, which produces a voltage proportional to an intensity of the magnetic field. The current is measured based on the voltage produced by the magnetic field sensor. | 04-04-2013 |
20130076372 | CHARACTERIZATION AND CORRECTION OF VOLTAGE PROBE, CURRENT PROBE AND CABLE - Responses of voltage and current probes are characterized or corrected. A voltage probe method includes measuring output of the voltage probe and a first output of a through, in response to an input signal applied to the through, with the voltage probe connected, measuring a second output of the through with the voltage probe disconnected, and characterizing the response of the voltage probe using the output of the voltage probe and the first and/or second outputs. A current probe method includes measuring output current of the current probe and first output current of a through, in response to an input signal applied to the through with the current probe connected in series, measuring second output current of the through with the current probe disconnected, and characterizing the response of the current probe using the output current of the current probe and the first and/or second output currents of the through. | 03-28-2013 |
20130067997 | SINGLE INJECTION VALVE FOR HPLC COMBINING SAMPLE INTRODUCTION, WASH CYCLES AND DIAGNOSIS - A switchable valve for a sample injector includes a first valve member and a second valve member that can moved with respect to the other. The first valve member includes a plurality of ports, the second valve member includes a plurality of fluid paths. The plurality of ports include eight circumferential ports distributed along a circumference and one central port arranged at a central position of the first valve member. The plurality of fluid paths include three arcuate fluid paths so as to be couplable with at least two of the circumferential ports and one straight fluid path extending between the central position and a circumferential position so as to be couplable with the central port and one of the circumferential ports. | 03-21-2013 |
20130062515 | IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS - In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. | 03-14-2013 |
20130043380 | CALIBRATION OF MASS SPECTROMETRY SYSTEMS - A method for operating a mass spectrometer (MS) includes establishing a pressure differential across a membrane wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source on a downstream side of the membrane; flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source; and maintaining the upstream pressure at a constant value. The calibrant may be flowed at a low flow rate. An MS system includes a membrane interposed between a calibrant gas introduction system and a mass spectrometer. The membrane may include an orifice of nano-scale diameter. | 02-21-2013 |
20130035261 | USE OF N-ALKYL IMIDAZOLE FOR SULFURIZATION OF OLIGONUCLEOTIDES WITH AN ACETYL DISULFIDE - A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources. | 02-07-2013 |
20130031288 | PCI-E SYSTEM HAVING RECONFIGURABLE LINK ARCHITECTURE - A peripheral component interconnect express (PCI-E) system has a reconfigurable link architecture. The system comprises a system slot adapted to receive a PCI-E compatible system controller, a plurality of peripheral slots adapted to receive a plurality of peripheral modules, and a reconfigurable switch fabric configured to create a variable number of PCI-E links between the system slot and the plurality of peripheral slots. | 01-31-2013 |
20130027152 | DRIFT STABILIZATION OF MAGNETICALLY TUNABLE FILTER BY TEMPERATURE REGULATION AND MECHANICAL ISOLATION OF ELCTROMAGNET COIL - An electromagnet structure comprises a magnetic shell having a cavity, a magnetic pole located within the cavity and having a magnetic gap for focusing a magnetic field on a magnetically tunable filter, a conductive coil located within the cavity of the magnetic shell and forming multiple turns around the magnetic pole, and a heater located within the cavity of the magnetic shell and configured to maintain the conductive coil at a substantially constant temperature when the magnetically tunable filter is tuned to different frequencies. | 01-31-2013 |
20130025347 | GAS CHROMATOGRAPH PROVIDING SEMI-AUTOMATIC IDENTIFICATION OF CONNECTED SAMPLE FLOW COMPONENTS, AND METHOD OF OPERATING SAME - A method for semi-automatically generating configuration information for a gas chromatograph uses an identification device reader of the gas chromatograph to 1) determine a presence and location of sample flow component identification devices in or on identification device holders that hold the sample flow component identification devices; 2) read information from sample flow component identification devices held in the identification device holders; and 3) output configuration information for the gas chromatograph. The configuration information is based on the presence and location of particular sample flow component identification devices in or on particular identification device holders, and on associations of particular identification device holders with particular sample flow component connections to the gas chromatograph. The configuration information indicates if and how sample flow components are connected to the gas chromatograph. | 01-31-2013 |
20130017545 | APPARATUS AND METHODS FOR ACQUIRING ANALYTES FROM A DRIED BIOLOGICAL FLUID SAMPLEAANM Yong; BenAACI Glenn DaleAAST MDAACO USAAGP Yong; Ben Glenn Dale MD USAANM Hudson; William C.AACI TustinAAST CAAACO USAAGP Hudson; William C. Tustin CA US - An apparatus for acquiring analytes from a dried biological fluid sample includes a tube, a substrate in a proximal section of the tube, and a sorbent bed in a distal section of the tube. A biological fluid sample is dispensed on the substrate and is dried to form a dried sample. A conditioning solvent is flowed into the distal section to condition the sorbent bed. A first elution solvent is flowed through the substrate and the sorbent bed. Analytes are eluted from the dried sample and retained on the sorbent bed. A second elution solvent is flowed through the substrate and the sorbent bed. The analytes are eluted from the sorbent bed, pass through an opening, and are collected. Alternatively, an elution solvent is flowed through the substrate and the sorbent bed such that analytes eluted from the dried sample pass through the sorbent bed and the opening for collection, while non-analytes are retained on the sorbent bed. | 01-17-2013 |
20130008859 | DRIFTING TWO-DIMENSIONAL SEPARATION WITH ADAPTION OF SECOND DIMENSION GRADIENT TO ACTUAL FIRST DIMENSION CONDITION - A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed. | 01-10-2013 |
20130008523 | INTAKE MONITORING FOR ACCURATE PROPORTIONING - A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information. | 01-10-2013 |
20130004772 | SUPERFICIALLY POROUS METAL OXIDE PARTICLES, METHODS FOR MAKING THEM, AND SEPARATION DEVICES USING THEM - Superficially porous hybrid particles include hybrid solid cores that each contain an inorganic material and an organic material; and porous hybrid outer shells each include the inorganic and organic materials and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 Å with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01° and 10° of a 2θ scan range; wherein the particles have a median size range from about 0.5 μm to about 100 μm with a particle size distribution (one standard deviation) of no more than 15% of the median particle size, wherein the inorganic material comprises a metal oxide selected from silica, alumina, titania or zirconia. | 01-03-2013 |
20130003804 | IMPAIRMENT COMPENSATION - A method is provided for compensating for impairment of an electrical signal output from a device under test (DUT), the impairment resulting from an impairment network. The method includes measuring an impaired electrical signal received at an electronic analyzer via the impairment network; applying a stimulus signal to the impairment network; estimating an impairment transfer function corresponding to the impairment based on the applied stimulus signal; and correcting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT. | 01-03-2013 |
20130003799 | IMPAIRMENT COMPENSATION - A method is provided for compensating for impairment of an electrical signal output from a device under test (DUT), the impairment resulting from an impairment network. The method includes measuring an impaired electrical signal received at an electronic analyzer via the impairment network; applying a coded pulse sequence to the impairment network; estimating an impairment transfer function corresponding to the impairment based on the applied pulse sequence; and correcting the measured electrical signal using the impairment transfer function to determine the electrical signal output from the DUT. | 01-03-2013 |
20130002325 | CONSTANT SWITCHING CURRENT FLIP-FLOP - A constant switching current flip-flop includes a latch circuit that provides latch outputs of the flip-flop, whereby the latch outputs are reset to zero at the beginning of each clock cycle to eliminate pattern dependent switching currents. The latch circuit is reset responsive to control signals provided without significant delay. | 01-03-2013 |
20130002251 | NUCLEAR MAGNETIC RESONANCE PROBE COMPRISING SLIT SUPERCONDUCTING COIL WITH NORMAL-METAL OVERLAYER - A nuclear magnetic resonance (NMR) probe comprises a superconducting material formed in a spiral having a plurality of fingerlets separated by a plurality of slits, and a normal-metal overlayer formed on the spiral over the plurality of fingerlets and the plurality of slits. | 01-03-2013 |
20130001416 | WINDOWLESS IONIZATION DEVICE - An ionization device comprises: a plasma source configured to generate a plasma. The plasma comprises light, plasma ions and plasma electrons. The plasma source comprises an aperture disposed such that at least part of the light passes through the aperture and is incident on a gas sample. The ionization device further comprises an ionization region; and a plasma deflection device comprising a plurality of electrodes configured to establish an electric field, wherein the electric field substantially prevents the plasma ions from entering the ionization region. | 01-03-2013 |
20130001145 | Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography - A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes. A micro-machined integrated frit and flow distributor device is also provided having a substrate with a thickness, holes extending through the thickness and providing fluid communication therethrough, and channels in fluid communication with at least one of the holes. A chromatography column is provided having a tube, an extraction medium contained therein, and a micro-machined frit positioned proximate an end of the tube. The column can include a micro-machined flow distributor positioned between the frit and the end of the tube. | 01-03-2013 |
20130000759 | MICROFLUIDIC DEVICE AND EXTERNAL PIEZOELECTRIC ACTUATOR - A fluid pumping device includes a piezoelectric actuator externally coupled to a microfluidic device. The piezoelectric actuator has an axial displacement along a lengthwise axis responsive to application of a bias voltage. The axial displacement of the piezoelectric actuator operates one of an internal valve and an internal pump chamber of the microfluidic device. | 01-03-2013 |
20130000758 | MICROFLUIDIC DEVICE AND EXTERNAL PIEZOELECTRIC ACTUATOR - A fluid pumping device includes a piezoelectric actuator externally coupled to a microfluidic device. The piezoelectric actuator has an axial displacement along a lengthwise axis responsive to application of a bias voltage. The axial displacement of the piezoelectric actuator operates one of an internal valve and an internal pump chamber of the microfluidic device. | 01-03-2013 |
20120318973 | ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND METHOD - An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore. | 12-20-2012 |
20120304343 | AUTOMATIC GAIN TUNING IN ATOMIC FORCE MICROSCOPY - A method for optimizing loop gain of an atomic force microscope (AFM) apparatus includes determining a change in gain of the physical system and adjusting a controller frequency response of the controller in an AFM loop to compensate for the determined change in gain. The AFM loop has a corresponding loop response that includes the product of the controller frequency response and a physical system response of the physical system. | 11-29-2012 |
20120295548 | SYSTEM FOR CHARACTERIZING MIXER OR CONVERTER RESPONSE - A network analyzer comprises: a signal source configured to supply an input signal to a device, wherein the device is configured to generate a phase reference signal; a receiver configured to receive the phase reference signal from the device and to measure a phase response of the device according to the phase reference signal; and a calibration component configured to compare the measured phase response of the device with an actual phase response of the device to identify a tracking parameter for the receiver. | 11-22-2012 |
20120289691 | PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS - A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure: | 11-15-2012 |
20120289426 | METHOD FOR AMPLIFICATION OF TARGET NUCLEIC ACID - A method for amplifying a target nucleic acid is disclosed, which includes: (a) fragmenting a nucleic acid sample to create a target fragment comprising a target nucleic acid and two probe-complementary portions; (b) contacting said fragmented nucleic acid sample with a probe comprising two target fragment-complementary portions complementary to the probe-complementary portions of the target fragment; (c) rendering the fragmented nucleic acid sample single-stranded; (d) allowing the probe-complementary portions to hybridise with the target-fragment complementary portions; (e) if the probe in step (b) is not immobilised, immobilising the probe-target fragment hybrid on a solid phase via immobilisation moiety; (f) separating non-immobilised nucleic acid fragments from the solid phase; (g) contacting the solid phase with a ligase to ligate ligatable 5′ and 3′ ends of the target fragment whereby the target fragment is circularized; and (h) amplifying said circularized target fragment. | 11-15-2012 |
20120285558 | PUMP REDUCING A FLUID FLOW BY A DETERMINED AMOUNT - A fluid pump for a fluid separation device for separating a fluid includes a fluid inlet being supplyable with fluid at an inlet pressure (pI), and a fluid conducting mechanism configured for conducting the fluid supplied to the fluid inlet towards a connected fluidic path, in which the fluid conducting mechanism is controllable so that, regardless of a value of the inlet pressure (pI), the fluid is continuously conducted away from the fluid inlet with a definable flow rate (FT). | 11-15-2012 |
20120274313 | OSCILLOSCOPE WITH INTERNALLY GENERATED MIXED SIGNAL OSCILLOSCOPE DEMO MODE STIMULUS, AND INTEGRATED DEMONSTRATION AND TRAINING SIGNALS - An oscilloscope includes at least one demonstration signal generator integrated as part of the oscilloscope. The demonstration signal generator generates stimulus signals that consist of digital samples of various different stored waveforms without the need of a separate demonstration board or signal source. The demonstration signal generator may loop through different sections of the stored waveforms to generate respective stimulus signals that include sequences of digital samples from the different waveforms in combination, to provide a broad range of stimulus signals. The stimulus signals may be displayed on the oscilloscope or output from the oscilloscope as demonstration mode stimulus signals to demonstrate the capabilities of the oscilloscope to customers or for training. | 11-01-2012 |
20120268101 | OSCILLOSCOPE WITH INTEGRATED GENERATOR AND INTERNAL TRIGGER - An apparatus, includes an oscilloscope and a waveform generator. The waveform generator is integrated in a common housing with the oscilloscope, and configured to provide a stimulus signal as an output of the apparatus and to provide a trigger signal that is connected internally to the oscilloscope for triggering the oscilloscope. | 10-25-2012 |
20120265448 | BALANCED FEATURE DISPLAY IN FLUIDIC SAMPLE SEPARATION - A device for processing measurement data assigned to a measurement on a fluidic sample to be separated, the measurement data having multiple features being indicative of different fractions of the fluidic sample, the device includes a feature position analysis unit configured for analyzing positions (p | 10-18-2012 |
20120251410 | FLUIDIC CHIP WITH LAMINATED REINFORCING LAYER FOR PRESSURE REINFORCEMENT - A fluidic chip device configured for processing a fluidic sample includes two outer boundary layers, and at least one reinforcing layer arranged between the two outer boundary layers and being at both of its opposing main surfaces laminated with directly adjacent layers to reinforce pressure resistance of the fluidic chip device by the lamination, in which at least a part of the layers of the fluidic chip device includes a hole forming at least a part of a fluidic conduit for conducting the fluidic sample under pressure. | 10-04-2012 |
20120243595 | METHOD AND SYSTEM FOR PROVIDING PHASE REFERENCE SIGNAL - A method and system of providing a phase reference signal includes generating a reference signal having a reference frequency, modulating the reference signal at a modulation frequency lower than the reference frequency to obtain a modulated drive signal, receiving the modulated drive signal at a phase reference, and generating the phase reference signal based on the modulated drive signal. The phase reference signal including multiple reference tones having corresponding tone frequencies clustered around multiples of the reference frequency. A spacing between adjacent tones of the multiple reference tones is the same as the modulation frequency or an integer multiple of the modulation frequency. | 09-27-2012 |
20120238737 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS - Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention. | 09-20-2012 |
20120220479 | PROBES FOR SPECIFIC ANALYSIS OF NUCLEIC ACIDS - The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said single-stranded portion is sufficient to allow hybridisation of at least part of the single-stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single-stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single-stranded portion of said target fragment, and comprising at the other end a second non-target-specific part which comprises a nucleotide sequence complementary to at least a portion, including one end, of oligonucleotide B of the probe, and (ii) oligonucleotide B is a single-stranded oligonucleotide which may contain or carry at least one element for detection and/or enrichment of said target fragment, and of which at least a portion, including one end, is complementary in sequence to the second non-target-specific part of oligonucleotide A, such that said target fragment becomes annealed to said probe through hybridisation to the first target-specific part of oligonucleotide A resulting in only one target-specific probe-binding event per target fragment; (d) ligating oligonucleotide B of said probe to the part of the single-stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) detecting or enriching for said probe-target fragment hybrid. Kits for use in the method of the invention are also provided. | 08-30-2012 |
20120216886 | PRIMARY PISTON CORRECTION DURING TRANSFER - A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle. | 08-30-2012 |
20120212224 | SUSPENDED SUBSTRATE CIRCUITS AND NUCLEAR MAGNETIC RESONANCE PROBES UTILIZING SAME - A nuclear magnetic resonance (NMR) probe circuit assembly includes one or more probe circuits in signal communication with one or more respective sample coils configured for transmitting and/or receiving radio-frequency (RF) energy to and/or from a sample of interest. One or more of the probe circuits have a suspended substrate configuration in which variable capacitors share a common dielectric substrate that is separated from a ground plane by an air gap. Each variable capacitor includes an electrode that is movable by a user-actuated adjusting device. One or more of the probe circuits may have a multiply resonant or broadband configuration, and may have one or more individual channels. One or more of the variable capacitors enable tuning to resonant frequencies of selected nuclei. One or more other variable capacitors may enable impedance matching. | 08-23-2012 |
20120198919 | LIQUID SUPPLY WITH OPTIMIZED SWITCHING BETWEEN DIFFERENT SOLVENTS - A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line. | 08-09-2012 |
20120198913 | COLUMN ASSEMBLY FOR A GAS CHROMATOGRAPH - A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary column to the fluid in the tube. | 08-09-2012 |
20120195809 | APPARATUS AND METHODS FOR MICROFLUIDIC APPLICATIONS - Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape. | 08-02-2012 |
20120194373 | DEVICE AND METHOD FOR DRIVING DIGITAL-TO-ANALOG CONVERTER - A device for driving a switch in a digital-to-analog converter (DAC) includes first and second latches, and a logic gate. The first latch is configured to store a digital input data signal according to a clock signal, and to output a first latch signal corresponding to the stored digital input data signal. The second latch is configured to store the first latch signal output by the first latch according to a logical inverse of the clock signal, and to output a second latch signal corresponding to the stored first latch signal. The logic gate is configured to perform an OR logic operation on the first latch signal and the second latch signal, the logic gate outputting a drive signal for driving a switch in the DAC connected to a current source. | 08-02-2012 |
20120193524 | MASS SPECTROMETER AND MASS ANALYZER COMPRISING PULSER - A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite one another, parallel to one another, and axially offset from one another. One of the pair of planar electrodes comprises an opening. The mass analyzer comprises an ion mirror disposed between the pair of planar electrodes. A mass spectrometer and a mass spectrometry method are also described. | 08-02-2012 |
20120184724 | PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS - A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more | 07-19-2012 |
20120164026 | CERAMIC INJECTION NEEDLE | 06-28-2012 |
20120160754 | DUAL MATERIAL APPROACH FOR HIGH PRESSURE BIO INERT FLOW PATH COMPONENTS - A method of manufacturing a component ( | 06-28-2012 |
20120160038 | LARGE-AREA SOLID PHASE EXTRACTION APPARATUS AND METHODS - A solid phase extraction apparatus includes a sample adsorption assembly and a needle. The adsorption assembly includes a housing, a distal housing opening, and an adsorption bar disposed in the housing. The adsorption bar includes an outer surface coated with an adsorption material. The adsorption bar is located between the distal housing opening and a proximal housing opening. The outer surface is spaced from an inner housing surface, wherein the adsorption assembly includes an adsorption region between the inner housing surface and the outer surface. The adsorption assembly establishes a fluid flow path from the distal housing opening, through the adsorption region along a longitudinal direction, and to the proximal housing opening. The needle communicates with the distal housing opening | 06-28-2012 |
20120159761 | MULTI-CHANNEL FILTER ASSEMBLY AND RELATED APPARATUS AND METHODS - A filter assembly includes a housing and filter elements. The housing includes internal chambers between first and second parallel outside surfaces, fluid inlet bores, and fluid outlet bores. Each internal chamber includes a filter element that partitions the internal chamber into an inlet chamber section and an outlet chamber section. The housing establishes a plurality of fluid flow channels from the inlet bores, through the inlet chamber sections, through the filter elements, through the outlet chamber sections and to the outlet bores, respectively. Each fluid channel includes a transverse fluid flow component in the inlet chamber section and the outlet chamber section. The filter assembly may be loaded into a filtering apparatus such that a plurality of separate fluid flow channels is established through the filter assembly. Fluid may be flowed through two or more of the fluid flow channels, wherein the fluid in each of the two or more fluid flow channels passes through the respective filter element and is filtered thereby. | 06-28-2012 |
20120153955 | MRI Short Coils - According to one aspect, a magnetic resonance imaging (MRI) scanner includes a short birdcage (e.g. millipede) distributed-capacitance radio-frequency (RF) coil formed from one or more patterned planar conductive foils. The transverse extent (e.g. diameter) of the coil is at least a factor of 3, for example about a factor of 10, larger than the longitudinal (z-axis) extent of the coil. Flux-return gaps may be provided between the sample measurement volume defined by the coil and RF shields adjacent to the sample measurement volume, to confine the RF magnetic field to the sample measurement volume. Exemplary coils described herein are particularly suited for very high-frequency MRI measurements. | 06-21-2012 |