Abbott Laboratories Patent applications |
Patent application number | Title | Published |
20160136192 | METHODS AND COMPOSITIONS FOR ENHANCING COGNITIVE PERFORMANCE - Compositions including an effective amount of each of phosphatidyl serine, choline, and oleic acid, and methods for improving cognitive performance that include administering such compositions to a subject, are described herein. The compositions can be nutritional compositions such as bars or liquids suitable for oral administration. The combination of phosphatidyl serine, choline, and oleic acid provides synergistic or complimentary modes of action that improve the overall effect of these compounds. | 05-19-2016 |
20160106131 | USE OF HMB TO IMPROVE QUALITY OF LIFE FOR HOSPITALIZED PATIENTS - A method of care is described that includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to an adult or elderly patient to improve the patient's quality of life during or after hospitalization of the patient. The improved quality of life may encompass the general health, physical health, or mental health of the patient. | 04-21-2016 |
20160066610 | METHODS FOR ENHANCING AGED MUSCLE REGENERATION - Compositions and methods for enhancing the regenerative capacity of an individual are provided. The compositions include, and the methods provide, a combination of an effective amount of epigallocatechin-3-gallate (EGCg) and an effective amount of beta-hydroxy-beta-methylbutyrate (HMB) to decrease the level of intramuscular FGF2, to enhance the regenerative capacity of muscle, or both. | 03-10-2016 |
20160054317 | ASSAY WITH INCREASED DYNAMIC RANGE - Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations. | 02-25-2016 |
20160038457 | METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION - Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition. | 02-11-2016 |
20160037817 | COMPOSITION COMPRISING A MULTIFUNCTIONAL VISCOSITY MODIFYING AGENT - A nutritional composition comprising at least one protein, at least one macronutrient other than the at least one protein, and micronized calcium phosphate. The micronized calcium phosphate has a median particle size from about 0.20 to about 1.20 micrometers and may modify the viscosity of the nutritional composition. The micronization of the calcium phosphate may provide for increased bioavailability of calcium and phosphate and protein stability in the nutritional composition. | 02-11-2016 |
20160037815 | NUTRITIONAL COMPOSITIONS INCLUDING CALCIUM BETA-HYDROXY-BETA-METHYLBUTYRATE, CASEIN PHOSPHOPEPTIDE, AND PROTEIN - Nutritional compositions that include calcium ?-hydroxy-?-methylbutyrate and protein, and methods of using and making the nutritional compositions are provided. Casein phosphopeptide is utilized to sequester the calcium ?-hydroxy-?-methylbutyrate to reduce the interaction between the divalent calcium ions and protein in the nutritional composition to improve the overall stability, shelf life, and viscosity of the nutritional composition, while also facilitating the absorption of calcium. | 02-11-2016 |
20160030466 | USE OF SPECIFIC CARBOHYDRATE SYSTEMS DURING PREGNANCY FOR IMPROVING BONE DEVELOPMENT AND FORMATION AND/OR FOR IMPROVING COGNITIVE AND CNS DEVELOPMENT IN OFFSPRING - The present disclosure is directed to the administration of specific carbohydrate systems to a pregnant and/or lactating woman for improving one or more characteristics in offspring, for example cognition and/or bone health. The carbohydrate system may include a slow rate of digestion simple carbohydrate, a complex carbohydrate, and a non-absorbent carbohydrate and/or an indigestible carbohydrate. | 02-04-2016 |
20160029683 | LOW CALORIE INFANT FORMULA CONTAINING BETA-HYDROXY-BETA-METHYLBUTYRIC ACID - Low calorie nutritional compositions comprising beta-hydroxy-beta-methylbutyric acid which may support accretion of lean body mass and development of a healthy body composition in term infants are provided. The low calorie nutritional compositions may be liquid or powder infant formulas. | 02-04-2016 |
20160029681 | METHOD OF ENHANCING BIOAVAILABILITY OF DHA AND OTHER LIPID-SOLUBLE NUTRIENTS - A method of enhancing the bioavailability of a lipid-soluble nutrient, such as DHA, arachidonic acid, tocopherol, and carotenoids, in a newborn or preterm infant is disclosed. In this method, the lipid-soluble nutrient is administered in a nutritional product (such as an infant formula) to a preterm or newborn infant. The nutritional product comprises (a) an effective amount of the lipid-soluble nutrient; and (b) a fatty component comprising a combination of: (i) at least 6 g/l predigested fat, wherein the predigested fat includes at least one of: monoglycerides, free fatty acids, or a combination of monoglycerides and free fatty acids, and (ii) at least 1.44 g/l phospholipid. A method of enhancing cognition in newborn or preterm infants utilizing the nutritional product is also disclosed. | 02-04-2016 |
20160029679 | USE OF SPECIFIC CARBOHYDRATE SYSTEMS DURING PREGNANCY FOR PREVENTING FAT ACCUMULATION IN PREGNANT WOMEN - Disclosed herein are methods related to the administration of specific carbohydrate systems to a pregnant woman for preventing or limiting fat accumulation. The carbohydrate system may include a slow rate of digestion simple carbohydrate, a complex carbohydrate, a non-absorbent carbohydrate, and/or an indigestible carbohydrate. The compositions may be administered before, during, or after gestation. | 02-04-2016 |
20160022710 | PRENATAL AND LACTATION SUPPLEMENTS TO ENHANCE CENTRAL NERVOUS SYSTEM DEVELOPMENT OF OFFSPRING - Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant. | 01-28-2016 |
20160022628 | INFANT NUTRITIONAL PRODUCT WITH RRR ALPHA-TOCOPHEROL - This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development. | 01-28-2016 |
20160022617 | TREATMENT OF INSULIN RESISTANCE ASSOCIATED WITH PROLONGED PHYSICAL INACTIVITY - Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future. | 01-28-2016 |
20160021921 | PRETERM INFANT NUTRITIONAL COMPOSITIONS CONTAINING BETA-HYDROXY-BETA-METHYLBUTYRIC ACID - Preterm infant nutritional compositions comprising beta-hydroxy-beta-methylbutyric acid for supporting growth, accretion of lean body mass, and a healthy body composition in preterm infants are provided. The preterm infant nutritional compositions may be liquid formulas, fortifiers, and supplements. Methods for supporting growth, accretion of lean body mass, and a healthy body composition in a preterm infant are also provided. The methods include administering a preterm infant nutritional composition comprising beta-hydroxy-beta-methylbutyric acid to the preterm infant. | 01-28-2016 |
20160021919 | METHODS OF STIMULATING INFANT LUNG AND GUT MATURATION - A method of enhancing maturation of a lung, gut, or both in an infant. The method includes the step of administering to the infant a nutritional composition including from about 3 weight % phospholipids to about 20 weight % phospholipids, based on total fat of the nutritional composition. | 01-28-2016 |
20160001940 | PRODUCT PACKAGE SEAL WITH PEELABLE TAB - A product package for storing nutritional or pharmaceutical products includes a container having a body and an opening, a seal ( | 01-07-2016 |
20150374024 | MICROBIAL REDUCTION IN NUTRITIONAL PRODUCT USING AN EXTRUSION PROCESS - A method of reducing a pathogenic microorganism population in a powdered nutritional food composition is described herein. The powdered nutritional food composition includes a fat, a protein, and a carbohydrate. The method includes forming an emulsion of the powdered nutritional food composition and extruding the emulsified powdered nutritional food composition at a temperature of less than about 100° C. The method produces at least a 5 log reduction in the pathogenic microorganism population in the extruded powdered nutritional food composition. The extruded powdered nutritional food composition has a water activity level of about 0.3 to about 0.95. | 12-31-2015 |
20150352071 | METHODS FOR REDUCING MUSCLE SORENESS AFTER EXERCISE USING BETA-HYDROXY-BETA-METHYLBUTYRATE - Nutritional compositions containing beta-hydroxy-beta-methylbutyrate (HMB) are administered to an individual to reduce muscle soreness after exercise. The compositions contain a source of HMB; a protein source with at least about 21% branched-chain amino acids, by weight of total protein in the protein source; and a carbohydrate blend which contains a combination of rapid release and sustained release carbohydrates. | 12-10-2015 |
20150351443 | HYDRATING COMPOSITIONS - Powdered and liquid hydrating compositions and methods for hydrating an adult subject are provided. The compositions may include a combination of carbohydrates, sodium, potassium, chloride, citric acid, and malic acid. The powdered compositions include an anti-caking agent. | 12-10-2015 |
20150342974 | NUTRITIONAL COMPOSITIONS COMPRISING NEUROPROTECTIVE DIETARY OLIGOSACCHARIDES - A nutritional composition for use in providing a neuroprotective effect to an individual in need thereof which nutritional composition comprises at least one human milk oligosaccharide selected from lacto-N-neotetraose and 2′-fucosyllactose. | 12-03-2015 |
20150342832 | LIQUID NUTRITION BOTTLE - A bottle for storing liquid nutrition and feeding liquid nutrition to an infant. The bottle includes a base portion, a neck portion for removably securing a cap or nipple, and a body portion disposed between the base portion and the neck portion. A rib protrudes from an outer surface of the bottle and is arranged for manual gripping by a user to manipulate a position of the bottle relative the infant. The outer surface of the bottle may include at least two remote and distinct outer surface areas which each define a cylindrical section of the bottle. Each surface area may be positioned for engagement by machinery during a filling operation. | 12-03-2015 |
20150320778 | HUMAN MILK OLIGOSACCHARIDES TO AMELIORATE SYMPTOMS OF STRESS - A nutritional composition comprising at least one human milk oligosaccharide selected from 6′ sialyllactose, lacto-N-neotetraose, lacto-N-tetraose, disialylated lacto-N-tetraose, 3′-fucosyllactose, and 3′-sialyllactose. The nutritional composition is used in a method of reducing stress in an individual in need thereof. | 11-12-2015 |
20150320102 | LOW VISCOSITY, HIGH CALORIC DENSITY ORAL NUTRITIONAL COMPOSITION AND RELATED METHODS - Disclosed embodiments provide low viscosity, high caloric density liquid nutritional compositions. The use of non-micellar milk protein in combination with hydrolyzed caseinate and unique formulation methods allow for improved organoleptic qualities and the production of liquid nutritional compositions displaying low viscosity along with a high caloric density. | 11-12-2015 |
20150305394 | EXTRUDED NUTRITIONAL POWDERS HAVING IMPROVED EMULSION STABILITY AND DISPERSIBILITY AND METHODS OF MANUFACTURING SAME - Extruded nutritional powders and methods of manufacturing the extruded nutritional powders, including extruded infant nutritional powders and extruded adult nutritional powders are provided. The processes utilize an extruder that is capable of internally mixing and emulsifying protein, and optionally, a carbohydrate with fat and water into an emulsion that can be dried into a powder having equivalent fat separation and dispersibility as compared to spray dried powders. | 10-29-2015 |
20150296867 | METHODS FOR EXTRUDING POWERED NUTRITIONAL PRODUCTS USING A HIGH SHEAR ELEMENT - A method of producing an emulsion and an extrudate for a powdered nutritional product is provided. The method includes utilizing an extruder ( | 10-22-2015 |
20150290081 | CAP SUITABLE FOR USE WITH ENTERAL FEEDING CONTAINER - A cap for use in enteral feeding from a container. The cap includes a base and an insert cutter. The base has a top surface, a bottom surface, and an outer ring. The top surface has a protruding port suitable for insertion of a spike connector. The protruding port defines a spike insertion chamber extending from a spike connector insert aperture to a spike connector outlet aperture. The outer ring is configured for attachment to a container having a mouth. The insert cutter has a first end portion attached to the bottom surface of the base and about an edge of the spike connector outlet aperture and a second end portion extending over at least a portion of the spike connector outlet aperture. The insert cutter is capable of flexing in an insertion direction of a spike connector inserted through the spike insertion chamber. | 10-15-2015 |
20150265650 | METHODS FOR ENHANCING THE EFFECT OF EGCG ON MITIGATING SKELETAL MUSCLE LOSS - Disclosed herein are methods for enhancing the efficacy of epigallocatechin gallate (“EGCg”) in mitigating skeletal muscle loss in a subject. Providing EGCg to a subject in a nutritional composition reduces muscle protein degradation, thereby mitigating skeletal muscle loss in the subject. The combination of EGCg with zinc in a nutritional composition enhances the mitigating effect that EGCg has on muscle loss. Specifically, when used in combination, a nutritional composition containing both EGCg and zinc requires less EGCg to obtain the same mitigating effect that occurs in the same nutritional composition containing EGCg but no zinc. | 09-24-2015 |
20150250221 | SHELF-STABLE, CLEAR LIQUID NUTRITIONAL COMPOSITIONS COMPRISING EPIGALLOCATECHIN GALLATE (EGCG) AND METHODS FOR PREPARING THE SAME - Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein. | 09-10-2015 |
20150246011 | NUTRITIONAL COMPOSITIONS INCLUDING CALCIUM BETA-HYDROXY-BETA-METHYLBUTYRATE, PROTEIN AND LOW LEVELS OF ELECTROLYTES - Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition. | 09-03-2015 |
20150238508 | METHODS FOR MODULATING CORTICOSTERONE LEVELS IN PSYCHOLOGICALLY STRESSED INDIVIDUALS - Disclosed are methods of modulating and/or decreasing serum corticosterone levels in an individual affected by stress. Further disclosed are methods of modulating the hypothalamic pituitary adrenal response in an individual. The methods include administration of 2-fucosyl-lactose to an individual. | 08-27-2015 |
20150238447 | BETA-HYDROXY-BETA-METHYLBUTRYIC ACID-CONTAINING COMPOSITIONS AND USES THEREOF - Disclosed are compositions, such as liquid and solid nutritional compositions, that contain beta-hydroxy-beta-methylbutyric acid and optionally at least one protein, carbohydrate, fat, or a combination of protein, carbohydrate, and fat. Also disclosed are methods of using the compositions for improving physical endurance, locomotion, mobility and cognition in an individual, including a pediatric individual. | 08-27-2015 |
20150237903 | HIGH PROTEIN, LOW VISCOSITY LIQUID NUTRITIONAL PRODUCT WITH HMB - Nutritional products with improved organoleptic properties are provided herein. The general inventive concepts provide liquid nutritional products with improved viscosities while providing relatively higher levels of protein. In certain exemplary embodiments, the liquid nutritional products further provide beta-hydroxy-beta-methylbutyrate in addition to relatively higher levels of protein while maintaining a pleasant mouthfeel when consumed. | 08-27-2015 |
20150231159 | METHODS FOR INCREASING BRAIN FUNCTIONALITY USING 2-FUCOSYL-LACTOSE - Disclosed are methods for enhancing learning and/or memory, enhancing memory acquisition, memory retention and recall by inducing a higher long-term potentiation in hippocampal neuronal synapsis in individuals. The methods include administration of 2-fucosyl-lactose to an individual. | 08-20-2015 |
20150208706 | POWDERED NUTRITIONAL COMPOSITIONS COMPRISING A DRYBLENDED NEAT CEREAL BETA-GLUCAN AND RESISTANT STARCH - Disclosed are nutritional compositions comprising a dryblended mixture of a neat cereal beta-glucan and a resistant starch. The dryblending of the neat cereal beta-glucan and the resistant starch improves the cold water solubility of the nutritional compositions. The dryblended nutritional compositions may further include a | 07-30-2015 |
20150196692 | MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS - System for treating vascular disease comprising a balloon having an outer surface for temporary contact with a vessel wall when in an expanded state, a coating disposed on at least a portion of the outer surface, the coating including an initial amount of a cytostatic agent selected from the group consisting of Zotarolimus (ABT578), everolimus, pimecrolimus, and a combination thereof, the coating being capable of maintaining a therapeutically effective amount of the cytostatic agent on the outer surface for delivery to a vessel wall, and further wherein between about 4.9% to about 23% of the initial amount of the cytostatic agent on the outer surface remains disposed on the outer surface after delivery of the therapeutically effective amount of the cytostatic agent to the vessel wall, and optionally, a stent disposed on the balloon. | 07-16-2015 |
20150140161 | METHODS OF IMPROVING TOLERANCE RELATED TO FEEDING IN AN INFANT, TODDLER, OR CHILD - Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component. | 05-21-2015 |
20150133548 | COMBINATION OF BETA-HYDROXY-BETA-METHYLBUTYRATE, ARGININE AND GLUTAMINE FOR USE IN TREATING DIABETIC ULCERS - Disclosed is the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for use in a method of treating a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g/dL, and/or (b) an Ankle-Brachial Index of less than 1.0. 9. Also disclosed is the use of the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for the manufacture of a medicament for use in the treatment of a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g/dL, and/or (b) an Ankle-Brachial Index of less than 1.0. In certain embodiments, the combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine are orally administered via a nutritional composition. | 05-14-2015 |
20150132466 | NUTRITIONAL PRODUCTS INCLUDING A NOVEL FAT SYSTEM INCLUDING FATTY ACIDS - Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component. | 05-14-2015 |
20150129597 | CONTAINER - A container ( | 05-14-2015 |
20150119339 | USE OF HMB TO IMPROVE HEALTH OUTCOMES FOR HOSPITALIZED PATIENTS - A method of care is described that includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to an adult or elderly patient to decrease the risk of an adverse health event during or subsequent to hospitalization of the patient. | 04-30-2015 |
20150110919 | STERILIZED LIQUID PROTEIN SUPPLEMENT INCLUDING A SOLUBILITY ENHANCING NUTRITIONAL PROTEIN - Disclosed are substantially stable sterilized liquid protein supplements including a highly soluble protein source for use with human milk and other infant or adult feeding formulas. The sterilized liquid protein supplements have a more neutral pH, thereby inhibiting protein denaturation and reducing microbial growth. In one aspect, the sterilized liquid protein supplement comprises at least 250 mg of protein per 1 ml, the protein has a degree of hydrolysis of 25% to 45%, a molecular weight median of less than 800 Daltons, and a dipeptide and tripeptide concentration of no more than 40% by weight total protein, wherein the sterilized liquid protein supplement has a pH of 3 to 8. | 04-23-2015 |
20150064220 | METHODS FOR MODULATING CELL-MEDIATED IMMUNITY USING HUMAN MILK OLIGOSACCHARIDES - Disclosed are methods of enhancing cell-mediated immunity in an individual using nutritional compositions including human milk oligosaccharides. The human milk oligosaccharides are sialylated human milk oligosaccharides, fucosylated human milk oligosaccharides, or a combination of both. The human milk oligosaccharides may enhance T-cell mediated responses and T-cell regulatory responses. | 03-05-2015 |
20150057350 | FIBROSIS BIOMARKERS AND METHODS OF USING SAME - Methods and systems for using fibrosis biomarkers associated with a prolonged period of physical inactivity are provided. Also provided is a method of reducing the effect of prolonged physical inactivity on the development of fibrosis in a subject who is experiencing or is expected to experience prolonged physical inactivity in the near future by administering a therapeutically effective amount of a leucine metabolite (e.g., β-hydroxy-β-methylbutyric acid (HMB)) to the subject. | 02-26-2015 |
20150057346 | METHODS OF MAINTAINING INTRAMUSCULAR MYOGLOBIN LEVELS, MAINTAINING MAXIMAL AEROBIC CAPACITY, AND ENHANCING THE OXIDATIVE CAPACITY OF MUSCLE IN A SUBJECT - Methods of maintaining intramuscular myoglobin levels, maintaining maximal aerobic capacity, and enhancing the oxidative capacity of muscle in a subject in need thereof are provided. Generally, the methods include administering an effective amount of β-hydroxy-β-methylbutyrate to the subject. The β-hydroxy-β-methylbutyrate may be administered as part of a nutritional composition. | 02-26-2015 |
20150031645 | METHODS OF USING HUMAN MILK OLIGOSACCHARIDES FOR IMPROVING AIRWAY RESPIRATORY HEALTH - Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to preterm infants, term infants, toddlers, and children for improving airway defense mechanisms. | 01-29-2015 |
20150025143 | BETA-HYDROXY-BETA-METHYLBUTYRIC ACID FOR IMPROVING GLUCOSE TOLERANCE - The use beta-hydroxy-beta-methylbutyric acid for improving glucose tolerance in a pediatric individual or in an adult individual is disclosed. In certain embodiments, the beta-hydroxy-beta-methylbutyric acid is administered via a nutritional composition. | 01-22-2015 |
20150025133 | NUTRITIONAL COMPOSITIONS INCLUDING RRR-ALPHA TOCOPHEROL AND POLYUNSATURATED FATTY ACIDS - Disclosed are nutritional formulas generally, and infant formulas specifically, including a combination of RRR-alpha tocopherol, LC-PUFAs, and optionally vitamin C. The combination enhances brain development and improves cognitive performance in an individual, and specifically in an infant. | 01-22-2015 |
20150024112 | INFANT FORMULAS CONTAINING DOCOSAHEXAENOIC ACID AND LUTEIN - Disclosed are infant formulas and corresponding methods of using them to promote retinal health and vision development in infants. The formulas, which are free of egg phospholipids and comprise fat, protein, carbohydrate, vitamins, and minerals, including docosahexaenoic acid and, on a ready-to-feed basis, at least about 50 mcg/liter of lutein, wherein the weight ratio of lutein (mcg) to docosahexaenoic acid (mg) is from about 1:2 to about 10:1. The formulas are also believed to be especially useful in reducing the risk of retinopathy of prematurity in preterm infants. | 01-22-2015 |
20150011498 | USE OF A REDUCED CALORIE INFANT FORMULA CONTAINING NUCLEOTIDES AND/OR CAROTENOIDS FOR REDUCING ADVERSE HEALTH EFFECTS LATER IN LIFE - The present disclosure is directed to reduced calorie infant formulas, and in particular, reduced calorie infant formulas that have at least one nucleotide and/or at least one carotenoid for reducing inflammation-related diseases later in life. Particularly, the reduced calorie infant formulas reduce the risk of obesity later in life. | 01-08-2015 |
20140374429 | CONTAINER - A container ( | 12-25-2014 |
20140370155 | STABILIZED CONCENTRATED LIQUID HUMAN MILK FORTIFIER - Disclosed are shelf-stable concentrated liquid human milk fortifiers including extensively hydrolyzed casein. The long term shelf stable, concentrated liquid human milk fortifiers include octenyl succinic acid (OSA) modified waxy potato starch as a stabilizer. | 12-18-2014 |
20140370153 | CONCENTRATED LOW WATER ACTIVITY LIQUID HUMAN MILK FORTIFIER INCLUDING EXTENSIVELY HYDROLYZED PROTEIN - Disclosed are concentrated liquid human milk fortifiers including extensively hydrolyzed casein, and optionally a probiotic. The concentrated liquid human milk fortifier has a low water activity and a low pH, thereby reducing microbial growth in the fortifier. | 12-18-2014 |
20140352409 | DEVICE FOR DETECTING LEAKS IN PACKAGES - A device for detecting leaks or weaknesses in a flexible package. The device includes a first member having a non-conductive surface, a second member secured in a position adjacent the first member, and a control system. The second member has an electrically conductive first portion and an electrically conductive second portion. The electrically conductive first portion of the second member is normally electrically insulated from the electrically conductive second portion of the second member. The control system is arranged to detect an electrical current between the electrically conductive first portion and the electrically conductive second portion. The second member may be positioned relative the first member to compress a flexible package between the first member and the second member. | 12-04-2014 |
20140335259 | METHODS FOR REDUCING MICROBIAL CONTAMINATION OF DRYBLENDED POWDERED NUTRITIONAL COMPOSITIONS - Disclosed are methods of preparing dryblended powdered nutritional compositions including at least one dry ingredient that has undergone a microbial inactivation heat treatment sufficient to inactivate microbes present therein. The heat treatment comprises subjecting the dry ingredient to a temperature of greater than 48° C. to no greater than 60° C. for a period of from 2 days to 30 days and allows for incorporation of the dry ingredient into the dryblended powdered nutritional composition without risk of substantial microbial contamination of the composition, and further, without substantially altering the physical and functional properties of the dry ingredient. | 11-13-2014 |
20140335258 | STABILIZED NUTRITIONAL COMPOSITIONS INCLUDING STARCH - Disclosed are stabilized nutritional compositions having a stabilizer system including starch, or a combination of starch and maltotriose, and methods for manufacturing the compositions. The retrogradation effect commonly seen with starch stabilizers is substantially reduced or even eliminated in the disclosed nutritional compositions. | 11-13-2014 |
20140335065 | HUMAN MILK OLIGOSACCHARIDES FOR PREVENTING INJURY AND/OR PROMOTING HEALING OF THE GASTROINTESTINAL TRACT - Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, children, and adults for preventing injury and/or improving the healing of the gastrointestinal tract. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed. | 11-13-2014 |
20140322425 | CONCENTRATED HUMAN MILK FORTIFIER LIQUID - Disclosed are concentrated, liquid, human milk fortifier compositions comprising from protein, carbohydrate and fat. The concentrated compositions are formulated for addition to human milk and are especially useful for providing nutrition to preterm infants in neonatal intensive care units or similar other institutional settings. | 10-30-2014 |
20140314942 | METHOD OF TRANSFORMING A MEAL - Disclosed are methods of transforming a meal to improve the suitability of the meal for an individual with specific dietary needs that may be due to a medical condition. The methods include assessing the meal relative to the individual's dietary needs and administering a composition to the meal that tailors the meal to the dietary needs of the individual. The composition comprises a nutrient for fortifying the meal and an anti-nutrient for reducing the absorption of undesirable components of the meal. | 10-23-2014 |
20140308393 | REDUCED CALORIE INFANT FORMULAS CONTAINING SPECIFIC WHEY TO CASEIN RATIOS - The present disclosure is directed to nutrition systems including at least a first and a second reduced calorie infant formula having varying whey to casein protein weight ratios for reducing inflammation-related diseases later in life. Particularly, the nutrition systems may be administered to a newborn infant to reduce the risk of obesity later in life. | 10-16-2014 |
20140302223 | NUTRITIONAL COMPOSITIONS COMPRISING A SOLUBLE VISCOUS FIBER AND A POLYPHENOL-CONTAINING PLANT EXTRACT - Disclosed are nutritional compositions comprising a soluble viscous fiber and a polyphenol-containing plant extract. The viscosity of the nutritional compositions may be adjusted and controlled without varying the concentration of the soluble viscous fiber in the composition by including the polyphenol-containing plant extract. | 10-09-2014 |
20140294789 | GALACTOOLIGOSACCHARIDES FOR PREVENTING INJURY AND/OR PROMOTING HEALING OF THE GASTROINTESTINAL TRACT - Disclosed are nutritional compositions including galactooligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, children, and adults for preventing injury and/or improving the healing of the gastrointestinal tract. Additional suitable methods of using the nutritional compositions including the galactooligosaccharides are also disclosed. | 10-02-2014 |
20140287111 | USE OF ULTRASONIC ENERGY IN THE PRODUCTION OF NUTRITIONAL POWDERS - Disclosed are ultrasonically-produced nutritional powders and methods of manufacturing the nutritional powders, including ultrasonically-produced infant nutritional powders and ultrasonically-produced adult nutritional powders. | 09-25-2014 |
20140273272 | ASSAY WITH INTERNAL CALIBRATION - Provided herein are kits and methods for assays with internal calibration. | 09-18-2014 |
20140273245 | AUTOMATED DIAGNOSTIC ANALYZERS HAVING VERTICALLY ARRANGED CAROUSELS AND RELATED METHODS - Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel. | 09-18-2014 |
20140273242 | AUTOMATED DIAGNOSTIC ANALYZERS HAVING REAR ACCESSIBLE TRACK SYSTEMS AND RELATED METHODS - Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test, the analyzer having a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism. | 09-18-2014 |
20140272933 | HCV ANTIGEN-ANTIBODY COMBINATION ASSAY AND METHODS AND COMPOSITIONS FOR USE THEREIN - The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample. | 09-18-2014 |
20140272932 | HCV NS3 RECOMBINANT ANTIGENS AND MUTANTS THEREOF FOR IMPROVED ANTIBODY DETECTION - The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies. | 09-18-2014 |
20140272931 | HCV CORE LIPID BINDING DOMAIN MONOCLONAL ANTIBODIES - The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection. | 09-18-2014 |
20140257451 | MEDICAL DEVICE UTILIZING A NICKEL-TITANIUM TERNARY ALLOY HAVING HIGH ELASTIC MODULUS - Medical devices that include a Ni—Ti ternary alloy and methods for their manufacture. The medical devices described herein include at least one part fabricated from the Ni—Ti ternary alloy. In the Ni—Ti alloys, the ternary alloying element is selected to be compatible with Ni—Ti. Example Ni—Ti ternary alloys include nickel (Ni), titanium (Ti), and one or more of tantalum (Ta), hafnium (Hf), vanadium (V), zirconium (Zr), scandium (Sc), or yttrium (Y). By virtue of their compatibility with Ni—Ti, additions of the ternary alloying element(s) may substitute for titanium in the Ni—Ti phase up to the solubility of the ternary element and the remainder can exist as a second phase whose mechanical properties resemble that of the pure ternary element and whose elastic modulus exceeds that of the Ni—Ti matrix. | 09-11-2014 |
20140257247 | GUIDE WIRE UTILIZING A NICKEL-TITANIUM ALLOY HAVING HIGH ELASTIC MODULUS IN THE MARTENSITIC PHASE - Guide wire devices fabricated from a linear pseudo-elastic Ni—Ti alloy and methods for their manufacture. The Ni—Ti alloy that includes nickel, titanium, and about 3 atomic % (at %) to about 30 at % niobium (Nb). Cold working the Ni—Ti alloy stabilizes the alloy's martensitic phase and yields a linear pseudo-elastic microstructure where reversion to the austenite phase is retarded or altogether blocked. The martensitic phase of cold worked, linear pseudo-elastic Ni—Ti—Nb alloy has an elastic modulus that is considerably higher than the comparable cold worked, linear pseudoelastic binary Ni—Ti alloy. This yields a guide wire device that has better torque response and steerability as compared to cold worked, linear pseudoelastic binary Ni—Ti alloy or superelastic binary Ni—Ti alloy. | 09-11-2014 |
20140256980 | PROCESS FOR MANUFACTURING HMB AND SALTS THEREOF - A continuous process and system for manufacturing beta-hydroxy-beta-methylbutyrate (HMB) and salts thereof is provided. The continuous process includes providing at least one oxidant and diacetone alcohol, and combining the at least one oxidant with the diacetone alcohol in a first flow reactor to produce a product stream comprising HMB or a salt thereof. Optionally, the process includes a second flow reactor for the acidification of a salt of beta-hydroxy-beta-methylbutyrate to produce beta-hydroxy-beta-methylbutyrate in free acid form. | 09-11-2014 |
20140256674 | NUTRITIONAL FORMULATIONS INCLUDING HUMAN MILK OLIGOSACCHARIDES AND ANTIOXIDANTS AND USES THEREOF - Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases. | 09-11-2014 |
20140255246 | MEDICAL DEVICE HAVING NIOBIUM NITINOL ALLOY - Guide wire devices and other intra-corporal medical devices fabricated from a Ni—Ti—Nb alloy and methods for their manufacture. The Ni—Ti alloy includes nickel, titanium, and niobium either up to its solubility limit in Ni—Ti, or in amounts over 15 atomic percent so as to provide a dual phase alloy. In either case, the Ni—Ti—Nb alloy provides increased stiffness to provide better torque response, steerability, stent scaffolding strength, and similar properties associated with increased stiffness, while still providing super-elastic or linear pseudo-elastic properties. | 09-11-2014 |
20140249224 | METHODS FOR IMPROVING TOLERANCE, DIGESTION, AND LIPID SOLUBLE NUTRIENT ABSORPTION IN AN INFANT, TODDLER, OR CHILD - Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component. | 09-04-2014 |
20140249223 | METHODS FOR IMPROVING BRAIN DEVELOPMENT AND COGNITIVE FUNCTION USING BETA-HYDROXY-BETA METHYLBUTYRATE - Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases. | 09-04-2014 |
20140248412 | DRYBLENDED NUTRITIONAL POWDERS - Disclosed are reconstitutable nutritional powders comprising carbohydrate, protein, and lipid wherein at least one carbohydrate, such as lactose, and powdered lecithin have been dryblended into the reconstitutable nutritional powders. Also disclosed are methods of manufacturing a reconstitutable nutritional powder including dryblending at least one carbohydrate and powdered lecithin into a base nutritional powder. The nutritional powders provide for reduced foaming upon reconstitution. | 09-04-2014 |
20140243854 | SIZING AND POSITIONING ADAPTER FOR MEDICAL INSTRUMENTS - In accordance with the present invention there is provided apparatuses and methods for using a medical instrument including a sizing and positioning adapter. The apparatus comprises an adapter for a medical instrument, the adapt having a body having a shim portion and an instrument holding portion adjacent the shim portion, wherein the shim portion provides an enlarged peripheral surface adjacent the medical instrument such that when the medical instrument is held in the instrument holding portion and the medical instrument and body are inserted through an opening in a patient tissue, at least a portion of the enlarged peripheral surface is in contact with at least a portion of the periphery of the opening in the patient tissue. | 08-28-2014 |
20140242254 | POWDERED NUTRITIONAL FORMULATIONS INCLUDING SPRAY-DRIED PLANT PROTEIN - Disclosed are powdered nutritional formulations comprising at least one plant protein, such as pea protein, wherein at least a portion of the plant protein has been spray-dried and dry-blended into the nutritional formulation. The liquids derived from reconstituting the powdered nutritional formulations exhibit little or no undesirable mouthfeel and have improved viscosity charcteristics. | 08-28-2014 |
20140222032 | SUTURING DEVICE WITH SPLIT ARM AND METHOD OF SUTURING TISSUE - A device for suturing an opening in a tissue, having an elongated shaft, at least two arms movable to a deployed positioning which the arms are non-perpendicular to the shaft, the arms having needle receiving portions; and needles advanceable longitudinally along the shaft toward the needle receiving portions, the needles exiting through side walls of the shaft at a location proximal to the arms. | 08-07-2014 |
20140220198 | ULTRASONICALLY-TREATED NUTRITIONAL PRODUCTS HAVING EXTENDED SHELF LIFE - Disclosed are nutritional products and nutritional bars having increased shelf life. The nutritional product or nutritional bar is manufactured utilizing high power ultrasound in combination with an extrusion process or slabbing process. It has been found that by utilizing high power ultrasound during the manufacturing process of nutritional products and nutritional bars, that the resulting product has increased shelf life and improved texture. In some embodiments, the nutritional bars include a solid crisp matrix. | 08-07-2014 |
20140207384 | Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD. | 07-24-2014 |
20140200516 | BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING METABOLIC DISORDERS - Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II; aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant. | 07-17-2014 |
20140194904 | SUTURE TRIMMER - A suture trimmer including an elongate shaft including an elongate lumen extending proximally from a distal end of the elongate shaft, a transverse through-opening disposed proximal the distal end of the shaft, and a groove extending proximally from the distal end of the shaft to a distal end of the opening. A fitting is disposed within the elongate lumen at the distal end of the shaft and extends distally therefrom. A cutting member is slidably received within the lumen of the shaft and configured to move between a proximal end of the opening and the distal end of the opening and cut a suture disposed within and extending from the opening. | 07-10-2014 |
20140188045 | PROCESS FOR FOLDING DRUG COATED BALLOON - Device, system, method of coating an expandable member is provided. The method comprises providing an expandable member with a plurality of folds defined therein, the expandable member having a folded configuration and a fully expanded configuration at a rated nominal pressure. The expandable member is inflated to an initial pressure of from 10% to about 300% of nominal pressure. A therapeutic agent is disposed on at least a portion of the expandable member. The expandable member is partially deflated to an intermediate pressure by withdrawing an amount of inflation medium from the expandable member, and by applying an external force to the expandable member. | 07-03-2014 |
20140180312 | ARTICULATING SUTURING DEVICE AND METHOD - A device for closing an opening in tissue includes a shaft having a proximal end, a distal end, and a channel disposed between the proximal and distal ends. A pair of pins are disposed within the channel and cooperate with a slidable and axially movable foot. The foot extends distally from the channel with a flexible guidebody extending from a distal foot end of the foot. | 06-26-2014 |
20140170699 | TEST FOR DETECTING SPOILAGE IN A FLEXIBLE PACKET - An apparatus for detecting spoilage of the contents of a packet is disclosed. The apparatus includes a pair of holding panels ( | 06-19-2014 |
20140158688 | CONTAINER AND CLOSURE - A closure for a container is described. The container has an opening through which contents of the container are dispensed and a holding member ( | 06-12-2014 |
20140158533 | Biosensors and Methods of Preparing Same - A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner. | 06-12-2014 |
20140127793 | ALLELIC DISCRIMINATION ANALYSIS USING AN EFFICIENCY RELATED VALUE (EFR) - In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree of amplification of each target nucleic acid in the amplification reaction and the time point in the amplification reaction at which the amplitude is measured; determining an efficiency related transform of the data, determining an efficiency related value for each target nucleic acid that is the maximum magnitude of the efficiency related transform; and outputting the efficiency related values in the amplification reaction for each target nucleic acid, where the relative amplitudes of the efficiency related values for each target nucleic acid is an indicator of the presence of each of said nucleic acids in said sample. | 05-08-2014 |
20140117027 | CONTAINER WITH AGGREGATING FEATURE - A container for storing a liquid. The container includes at least one side wall and a bottom wall defining an interior space. The bottom wall has an interior surface which is defined by at least a first surface and a second surface. The first surface aggregates a residual amount of the liquid. The second surface has a slope toward the first surface for directing a residual amount of the liquid toward the first surface | 05-01-2014 |
20140113939 | METHODS FOR TREATING HYPERLIPIDEMIA WITH INTERMEDIATE RELEASE NICOTINIC ACID COMPOSITIONS HAVING UNIQUE BIOPHARMACEUTICAL CHARACTERISTICS - Methods for treating hyperlipidemia with intermediate release nicotinic acid formulations having unique biopharmaceutical characteristics, without causing drug-induced hepatotoxicity to a level which would require discontinuation of the therapy, are disclosed. According to the methods of the present invention, the intermediate nicotinic acid formulations are administered as a single dose once-a-day during the evening or at night. While the methods of the present invention contemplate administering the intermediate release nicotinic acid formulations at any time during a 24 hour period, it is preferable to administer them as a single dose during the evening or at night between about 6:00 pm. and 12:00 a.m., preferably between about 8:00 p.m. and 12:00 a.m., and most preferably between about 8:00 p.m. and 10:00 p.m. | 04-24-2014 |
20140102477 | CLEANING APPARATUS - An apparatus for cleaning an article includes a drive belt and a wiper belt. The drive belt defines a first article engaging surface substantially parallel to a second article engaging surface of the apparatus and positioned to receive the article between the first and second article engaging surfaces. The drive belt is powered to move in a first direction such that the first article engaging surface imparts a forward motive force on a side wall of the article. The wiper belt defines an article wiping surface positioned to contact the article, the wiper belt being powered to move in a second direction opposite the first direction such that the first article wiping surface imparts a rearward wiping force on the article. | 04-17-2014 |
20140088296 | IL-18 BINDING PROTEINS - The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-1 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental. | 03-27-2014 |
20140087381 | DOUBLE STRANDED LINEAR NUCLEIC ACID PROBE - A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches. | 03-27-2014 |
20140083879 | CUTTING AND DISPENSING CLOSURES - A closure ( | 03-27-2014 |
20140072996 | METHODS AND KITS FOR DETECTING HEMOGLOBIN IN TEST SAMPLES - The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored blood sample or to identify a hemolyzed plasma sample. The present invention also relates to kits for use in the above described methods. | 03-13-2014 |
20140072971 | PRAME DETECTION ASSAYS - Provided herein are molecular assays, including oligonucleotides and other reagents, for the detection and analysis of PRAME (Preferentially Expressed Antigen in Melanoma). The assays find use, for example, as diagnostic and prognostic applications, including use in assessing therapeutic courses of action. | 03-13-2014 |
20140066605 | PURIFICATION OF BIOLOGICAL CONJUGATES BY SIZE EXCLUSION CHROMATOGRAPHY - A method for separating a biological conjugate from an aggregate. The molecular weight of the biological conjugate ranges from about 10 kDa to about 1000 kDa. In one embodiment, the method comprises the steps of:
| 03-06-2014 |
20140044844 | WATER SOLUBLE NUTRITIONAL COMPOSITIONS COMPRISING CEREAL BETA-GLUCAN AND RESISTANT STARCH - Disclosed are nutritional compositions comprising agglomerated and/or co-dried particles comprising a cereal beta-glucan and a resistant starch. The agglomerated and/or co-dried particles improve the cold water solubility of the nutritional compositions. The nutritional compositions may be dryblended powdered nutritional compositions including the agglomerated and/or co-dried particles and optionally a | 02-13-2014 |
20140044381 | POUCH, METHOD OF MANUFACTURING A POUCH AND A METHOD OF DISPENSING A PRODUCT FROM A POUCH - A single-use pouch ( | 02-13-2014 |
20140039525 | LOADING A TISSUE CLOSURE DEVICE ONTO A DELIVERY DEVICE - A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means. | 02-06-2014 |
20140037798 | LIQUID NUTRITIONAL PRODUCTS COMPRISING METAL AMINO ACID CHELATES - Disclosed are shelf stable nutritional liquids including metal amino acid chelates. Metal amino acid chelates, such as copper amino acid chelates and iron amino acid chelates, limit the capacity of incompletely bound copper and iron to catalyze the oxidation of sensitive nutrients such as vitamins, particularly vitamin A, vitamin B12 and vitamin C, thereby imparting both nutritional benefits and sensory benefits to the nutritional liquids. | 02-06-2014 |
20140037797 | NUTRITIONAL PRODUCTS COMPRISING BETA-HYDROXY-BETA-METHYLBUTYRATE - Disclosed are shelf stable nutritional products including beta-hydroxy-beta-methylbutyrate (HMB) and an oxidatively active species such as iron or copper. The HMB restricts the capacity of the oxidative species to catalyze the oxidation of nutrients such as fatty acids and vitamins thereby imparting both nutritional benefits and sensory benefits to the nutritional products. | 02-06-2014 |
20140030420 | NUTRITIONAL POWDERS COMPRISING SPRAY DRIED HMB - Spray dried nutritional powders include soluble calcium, protein, and at least one of a soluble citrate, a soluble phosphate, and combinations thereof as at least one chelating agent. At least a portion of the soluble calcium is calcium HMB. At least a portion of the protein is soluble protein. The spray dried nutritional powders have a weight ratio of soluble calcium binding capacity to total soluble calcium of from about 2.3:1 to about 12:1. The calcium HMB, the at least one chelating agent, and the protein are spray dried together. | 01-30-2014 |
20140024050 | ANTIBODIES WHICH DETECT PIVKAII AND METHODS OF USE THEREOF - The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions. | 01-23-2014 |
20140018850 | VESSEL CLOSURE DEVICE - The present invention relates to closing an opening within a subcutaneous bodily vessel by using a spiral closure device to engage tissue around the opening. The spiral closure device is adapted to be threaded into the vessel wall surrounding the opening in the bodily vessel. A deployment mechanism may be used to rotate the spiral closure device. As the deployment mechanism is rotated the spiral closure device is rotated such that a tip of the spiral closure device engages the vessel wall around the opening in the bodily vessel. Continued rotation of the spiral closure device threads the closure device through the tissue around the opening. The closure device may have a tapered configuration in which the distal end is larger than the proximal end. As the distal end is threaded through the vessel wall, the narrowing closure device pulls the vessel wall tissue together, thereby effectively closing the opening. | 01-16-2014 |
20140018774 | CATHETER DEPLOYMENT DEVICE - An apparatus for deploying a needle within a lumen is provided. The apparatus includes a housing having a threaded bushing radially disposed therein. The bushing rigidly couples with a nose cone having a guide tip disposed at an end opposite the bushing for penetrating an arterial wall of a lumen. During operation, a user incrementally advances the bushing within the housing, thereby incrementally advancing the guide tip into the lumen. The nose cone also includes a flex guide having a slot configuration which couples with the guide tip which deploys into the lumen along with the guide tip. | 01-16-2014 |
20140017692 | METHOD AND KIT FOR DETECTING TARGET NUCLEIC ACID - [Problem] To provide a method for detecting a nucleic acid (such as DNA and RNA) under isothermal conditions, in particular a method by which a short-chain nucleic acid can be directly detected. [Solution] A method for detecting a target nucleic acid in a sample of the present invention comprises: (a) a step of preparing a first oligonucleotide which comprises, in the direction from 5′ to 3′, a first arbitrary sequence, an endonuclease recognition site that is used in a nicking reaction, and a sequence complementary to the target nucleic acid; (b) a step of carrying out a nucleic acid amplification reaction using the target nucleic acid contained in the sample as a primer in the presence of an endonuclease which recognizes the endonuclease recognition site that is used in a nicking reaction; and (c) a step of detecting an oligonucleotide which is obtained by the nucleic acid amplification reaction and comprises a sequence complementary to the first arbitrary sequence. | 01-16-2014 |
20140010913 | TOLERANCE IN A LOW CALORIE INFANT FORMULA - The present disclosure is directed to low calorie infant formulas, and in particular, low calorie infant formulas that have a low buffering capacity, exhibit an increased rate of protein hydrolysis and digestion, and have an improved tolerance, as compared to full calorie infant formulas. Also disclosed are low calorie liquid infant formulas that have a reduced (i.e., “low”) micronutrient content on a per volume basis, and exhibit an overall improvement in the physical properties of the formula, as compared to low calorie liquid infant formulas having a higher micronutrient content. | 01-09-2014 |
20140010912 | LOW CALORIE INFANT FORMULA WITH IMPROVED PHYSICAL ATTRIBUTES - The present disclosure is directed to low calorie infant formulas, and in particular, low calorie infant formulas that have a low buffering capacity, exhibit an increased rate of protein hydrolysis and digestion, and have an improved tolerance, as compared to full calorie infant formulas. Also disclosed are low calorie liquid infant formulas that have a reduced (i.e., “low”) micronutrient content on a per volume basis, and exhibit an overall improvement in the physical properties of the formula, as compared to low calorie liquid infant formulas having a higher micronutrient content. | 01-09-2014 |
20130345636 | CARRIERS FOR HEMOSTATIC TRACT TREATMENT - Apparatuses and methods for administering a hemostatic agent to the tissue surrounding an opening in a body lumen are disclosed. The apparatus can include a tissue-contacting region and an optional body lumen-penetrating region. At least one hemostatic agent is included as a component of a coating over and/or a mixture with the material of at least a portion of the tissue-contacting region. | 12-26-2013 |
20130341297 | DRINKING CONTAINER - A drinking container and its components are described. A cap for the baby bottle includes a reservoir for storage of a dry powder formula. A clamp ring locking indicator for a container is described. The locking indicator indicates when the clamp ring is correctly engaged to the container. A clamp ring also threads and locks to the container with an approximately 180 degree turn. A stir insert for the baby bottle is described. The stir insert is positioned in an interior of the container in order to promote the mixing of the dry powder formula with the liquid. The stir insert includes a paddle portion that oscillates or moves in a back-and-forth manner as the bottle is shaken or stirred. A system cup is described. A single container has different attachments for the period from newborn to childhood to allow a single cup to be used throughout that entire time period. | 12-26-2013 |
20130338228 | METHODS FOR FACILITATING MUSCLE RECOVERY AFTER A PERIOD OF DISUSE USING BETA-HYDROXY-BETA-METHYLBUTYRATE - Disclosed are methods utilizing beta-hydroxy-beta-methylbutyrate (HMB) for facilitating the recovery of muscle after a period of muscle disuse. The HMB facilitates the recovery of muscle mass in an individual and can also be used to prevent further muscle atrophy typically associated with muscle reloading after extended periods of muscle disuse in the individual. The methods disclosed may be particularly suitable for older adults. | 12-19-2013 |
20130337495 | HIGH SPEED SPOILAGE DETECTION USING AN ELECTROMAGNETIC SIGNAL - The present disclosure provides a system for inspecting cases of packages having a substance subject to spoilage. An electromagnetic signal (e.g., a terahertz frequency signal) is directed to each package in a case, and an attenuated signal is received and sampled to generate a set of data points corresponding to each package. A peak within each set of data points is detected, and the data points are shifted with respect to time to align the detected peaks with a predetermined time. The sets of shifted data points are compared to a mathematical model to determine whether the substance in the package is spoiled, and a labeling system marks cases containing spoiled substance. | 12-19-2013 |
20130337490 | SPOILAGE DETECTION USING ELECTROMAGNETIC SIGNAL AND MATHEMATICAL MODELING - The present disclosure provides a system for inspecting a package ( | 12-19-2013 |
20130337144 | NUTRITIONAL PRODUCTS COMPRISING CALCIUM HMB AND CONJUGATED LINOLEIC ACID - Disclosed are nutritional products comprising calcium beta-hydroxy-beta methylbutyrate, conjugated linoleic acid, and protein. The nutritional product forms include nutritional liquids and nutritional powders. The nutritional products not only provide benefits for individuals concerned with muscle health and functionality, but also exhibit physical stability, sensory and/or aesthetic benefits in each of the selected product forms. | 12-19-2013 |
20130330348 | ANTI-NGF ANTIBODIES AND THEIR USE - The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental. | 12-12-2013 |
20130324537 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS - The present invention relates to guanidine compounds of the general formula I | 12-05-2013 |
20130317597 | Stent Designs With Angled Connectors - Stent including a plurality of radially-expandable rings disposed adjacent one another along a longitudinal axis to define a tubular member having a proximal end portion, a distal end portion and an intermediate portion, each of the radially-expandable rings including a plurality of strut members defining a series of crowns proximate opposite ends thereof. The stent includes a number of first interconnection members, each first interconnection member extending at an angle relative to the longitudinal axis between a crown of a first radially-expandable ring and a crown of a second radially-expandable ring. The stent includes a number of second interconnection members, each second interconnection member extending at an angle relative to the longitudinal axis between a crown of the second radially-expandable ring and a crown of a third radially-expandable ring. The number of first interconnection members is different than the number of second interconnection members. | 11-28-2013 |
20130309289 | Drug Delivery From Stents - An intravascular stent has a coating comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2′-ethyltrimethylammonium phosphate inner salt, C | 11-21-2013 |
20130303628 | CURCUMINOID SOLID DISPERSION FORMULATION - A curcuminoid formulation, comprising a melt-processed solid dispersion product comprising one or more curcuminoids, a nutritionally acceptable thermoplastic polymer, and a phosphatide; providing an improved oral bioavailability compared to non-formulated crystalline curcuminoid. A method for producing said formulation. A nutritional product fortified with said formulation. Said formulation for use in the treatment or prophylaxis of cancer, conditions involving an inflammatory reaction, neurological disorders, cardiovascular disease, pulmonary disease, the formation of cholesterol gallstones, and parasitic infestation. | 11-14-2013 |
20130288269 | Biomarkers For Prediction Of Major Adverse Cardiac Events And Uses Thereof - The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient. | 10-31-2013 |
20130266700 | ULTRASONICALLY-ASSISTED EXTRUSION METHODS FOR MANUFACTURING POWDERED NUTRITIONAL PRODUCTS - Disclosed are methods of manufacturing powdered nutritional products, including powdered infant formulas and powdered adult nutritional products, using extrusion. The methods include utilizing ultrasonic energy in the extruder during manufacturing. The application of ultrasonic energy to the extruder allows the fat globules present in raw materials to be effectively emulsified by hydrated protein present in the feed stream such that the resulting powdered extruded product has a low free fat level, is less susceptible to oxidation and rancidity, and can be reconstituted without substantial fat separation. | 10-10-2013 |
20130266566 | METHODS OF INHIBITING FIBROSIS USING ANTI-PAI-1 ANTIBODIES - Provided are anti-PAI-1 antibodies or antibody fragments and methods of using them. | 10-10-2013 |
20130256308 | CONTAINER - A container ( | 10-03-2013 |
20130253539 | CLIP APPLIER AND METHODS OF USE - An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members. | 09-26-2013 |
20130243904 | NUTRITIONAL PRODUCTS HAVING IMPROVED ORGANOLEPTIC PROPERTIES - Disclosed are nutritional products comprising pea protein hydrolysates as a primary or sole source of protein. The nutritional products include nutritional liquids, powders, bars, and other food products, wherein the resulting nutritional products are physically stable over shelf life and provide favorable organoleptic properties. These nutritional products may be used as a nutritional source for individuals who are intolerant and/or allergic to cow milk proteins and soy proteins and/or who have malabsorption, maldigestion, or other gastroinstestinal conditions. | 09-19-2013 |
20130243789 | Multiple Gene Expression Including sORF Constructs and Methods with Polyproteins, Pro-Proteins and Proteolysis - Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. Also disclosed are independent aspects of conducting efficient expression, secretion, and/or multimeric assembly of proteins such as immunoglobulins. | 09-19-2013 |
20130237999 | ARTICULATING SUTURING DEVICE AND METHOD - Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot of the device can be inserted through the penetration and actuated so that the foot extends along the lumenal axis. The foot can carry suturing attachment cuffs with one end of the cuff adapted to receive a needle, while the other end receives suture. A portion of the foot and/or lumen of the shaft can receive a portion of the suture and can include friction reducing structure that aid with movement of the sutured during removal of the cuffs from within the penetration. | 09-12-2013 |
20130217145 | ANTIBODIES WHICH DETECT PIVKAII AND METHODS OF USE THEREOF - The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions. | 08-22-2013 |
20130205567 | FATIGUE-RESISTANT NICKEL-TITANIUM ALLOYS AND MEDICAL DEVICES USING SAME - Superelastic and/or shape memory nickel-titanium alloys having an increased fatigue life that is superior to known nickel-titanium alloys are disclosed. The nickel-titanium alloys have a minimum fatigue life that may be at least about 10 million strain cycles at a strain greater than about 0.75%. The minimum fatigue life may be due, at least in part, to the nickel-titanium alloy having at least one of an oxygen concentration of less than about 200 ppm, a carbon concentration of less than about 200 ppm, the absence of oxide-based and/or carbide-based inclusions having a size greater than about 5 microns (μm), the presence of an R-phase, or combinations of the foregoing. Articles manufactured from such fatigue-resistant nickel-titanium alloys can be more durable because they are more resistant to repetitive strain and crack propagation. | 08-15-2013 |
20130199519 | BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING METABOLIC DISORDERS - Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant. | 08-08-2013 |
20130190488 | APOPTOSIS PROMOTERS - Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member. | 07-25-2013 |
20130184643 | Balloon Catheter - A balloon catheter comprises a shaft having a proximal end and a distal end. An inflatable member is disposed adjacent the distal end of the shaft. The inflatable member has an inner inflatable member and an outer inflatable member disposed around the inner inflatable member. The inflatable members have different compliant properties. | 07-18-2013 |
20130184446 | MICROORGANISM NUCLEIC ACID PURIFICATION FROM HOST SAMPLES - The present disclosure provides systems, devices, and methods for purifying microorganism nucleic acid from a host sample, such as a whole blood sample from a human. In certain embodiments, devices and systems with multiple filters are employed and provide for the selective removal of blood cells and host nucleic acids from a sample in order to enrich for microorganism nucleic acid. | 07-18-2013 |
20130184278 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES - Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. | 07-18-2013 |
20130183717 | CHANNELS WITH CROSS-SECTIONAL THERMAL GRADIENTS - Provided herein are systems, devices, and methods for generating thermal gradients in channels and uses thereof. In particular, provided herein are system, methods, and devices employing first and second thermal layers positioned around a channel in order to create a thermal gradient across a cross-section of the channel having, for example, a nucleic acid denaturation zone, a nucleic acid annealing zone, and a nucleic acid polymerization zone. Such devices find use in, for example, nucleic acid amplification procedures, including digital polymerase chain reaction (dPCR) to temperature cycle droplets for amplification of nucleic acid templates within the droplets. | 07-18-2013 |
20130183657 | MATERIALS AND METHOD FOR DETECTING CYTOMEGALOVIRUS (CMV) - Methods and kits for amplifying cytomegalovirus (CMV) nucleic acid sequences in a sample comprising pairs of primers for amplification of UL34 and UL80.5 nucleic acid sequences or one or more reagents. | 07-18-2013 |
20130177974 | Accelerated Wright-Giemsa and May-Grunwald Staining Methods - The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grúnwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grúnwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures. | 07-11-2013 |
20130171622 | COMPOSITIONS AND METHODS FOR DETECTING VIRAL INFECTION USING DIRECT-LABEL FLUORESCENCE IN SITU HYBRIDIZATION - The present invention relates generally to assays for the detection of viral infection and/or prognosis of viral infection and associated disease states. In particular, the invention relates to directly labeled viral-related nucleic acids having significant diagnostic, prognostic, and screening utilities and methods of using the same. | 07-04-2013 |
20130171146 | DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES - The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β. | 07-04-2013 |
20130169963 | Flow Cytometry Systems and Methods for Blocking Diffraction Patterns - Flow cytometer systems are provided having intermediate angle scatter detection capability. In some aspects, systems are provided that include an intermediate angle scatter (IAS) light detector positioned to measure intermediate angle scatter emitted from a flow cytometer. The system further includes a mask disposed across a portion of the IAS light detector and positioned between the flow cell and the IAS light detector to cover at least a central portion of the IAS light detector so as to block a diffraction pattern observed at the detector. In some instances, the diffraction pattern is created by a flat beam profile irradiating the sample. Methods are also provided for configuring a flow cytometer to block a diffraction pattern created by (1) a flat laser beam profile irradiating a flow cytometer liquid sample, or (2) a mismatched index of refraction between a sheath fluid and a liquid sample in a flow cytometer. | 07-04-2013 |
20130167770 | Automated Smear Making Apparatus - An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface. | 07-04-2013 |
20130167768 | BLOOD SAMPLE TUBE INDICATOR - A blood sample apparatus includes a blood sample tube, a cap, and an indicator. The blood sample tube has an exterior surface, an inner cavity disposed within the exterior surface, and an open end. The cap closes the open end of the blood sample tube. The inner cavity is under a vacuum-seal or connected to a suction device for drawing a blood sample into the inner cavity. The indicator is attached to or includes a portion of the blood sample tube for indicating a type, or lack thereof, of blood additive disposed within the inner cavity. When the cap is removed from the open end of the blood sample tube the indicator remains attached to or still includes the portion of the blood sample tube. If the indicator is a label it extends around at least half of a perimeter of the blood sample tube. | 07-04-2013 |
20130167613 | Devices and Systems for Liquid Level Detection in Hematology Instruments, and Methods Related Thereto - A hematology instrument with liquid level detection for liquid in a container is provided. The hematology instrument includes a probe disposed next to a container site. The probe is displaceable relative to the container site to enter a container when positioned at the container site. Further, the probe is electrically grounded. The hematology instrument includes a capacitive sensor having at least one capacitive electrode disposed next to the container site. The capacitive sensor also has a detection module to detect capacitive changes at the at least one capacitive electrode when the probe contacts liquid in the container. The hematology instrument also includes a calibration module configured to calibrate the capacitive sensor a plurality of times as the probe displaces relative to the container site to enter the container. Kits and methods related thereto are also provided. | 07-04-2013 |
20130165394 | AMINO ACID COMPOSITION FOR IMPROVING GLUCOSE TOLERANCE - Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The compositions are especially useful in treating individuals afflicted with impaired glucose tolerance or diabetes. | 06-27-2013 |
20130164767 | ASSAYS FOR HUMAN NT-PRO B-TYPE NATRIURETIC PEPTIDE, HUMAN PRO B-TYPE NATRIURETIC PEPTIDE AND HUMAN B-TYPE NATRIURETIC PEPTIDE - The present disclosure relates to assays for detecting and/or quantifying the amount of human NT-pro B-type natriuretic peptide, human pro B-type natriuretic peptide and human B-type natriuretic peptide in a test sample. | 06-27-2013 |
20130164740 | Cellular Analysis of Body Fluids - Herein is provided a simple, reliable and accurate method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation and/or differentiation between red blood cells (RBCs) and white blood cells (WBCs) by utilizing a fluorescent dye to selectively stain WBCs such that they emit stronger fluorescence signals. The method provides optimal detection limits on WBCs and RBCs, thereby allowing analysis of samples with sparse cellular concentrations. As few as one reagent may be used to prepare a single dilution for body fluid analysis, in order to simplify the body fluid analysis. Minimal damage to WBCs is attained using the lysis-free approach described in aspects of the disclosure. | 06-27-2013 |
20130159135 | SYSTEM AND METHOD FOR AUTOMATED LABORATORY INVENTORY MANAGEMENT USING RFID TECHNOLOGY - In one aspect, a computer readable memory medium comprising program instructions for graphically developing a connectivity driver is provided. The computer readable memory medium is a non-transitory medium. The program instructions are executable by a processor to generate a purchase order for a laboratory item, transmit the purchase order to a remote computer in order to communicate the purchase order to a vendor, receive an advance shipping notice generated in response to the purchase order, receive item information stored in an RFID tag of a tagged item received at the delivery location, and check the item information against the advance shipping notice in order to verify that the tagged item is the same as the ordered laboratory item. The purchase order specifies a delivery location. | 06-20-2013 |
20130150367 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. | 06-13-2013 |
20130149313 | ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF - The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products. | 06-13-2013 |
20130138122 | DEVICE AND METHOD FOR SUTURING INTRACARDIAC DEFECTS - In accordance with the present invention there is provided a suturing device. The suturing device includes a length of suture that will be delivered to the site of the PFO and placed through the tissue adjacent the opening to close the PFO. As described in greater detail below, the suture is advanced through the tissue surrounding the opening by a pair of needles that penetrate the tissue adjacent to the opening. A knot is then loosely tied with the length of suture and advanced to the site of the PFO. The tails of the suture extending from the knot are then cut and removed. It is also contemplated that a pre-formed or pre-tied knot may be disposed on the device, wherein after deployment of the suture through the tissue adjacent to the PFO and removal of the device a loop of suture having a pre-tied knot will remain, wherein the pre-tied knot may then be tightened to close the PFO. Further still it is contemplated that other means may be utilized to retain the sutures. For example, it is contemplated that a suture clip or other clip like device may be utilized to retain the suture in a position such that the PFO is closed. | 05-30-2013 |
20130131085 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF - The present invention features compounds of formula I | 05-23-2013 |
20130130233 | MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS AND USES THEREOF - The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample. | 05-23-2013 |
20130122183 | MEDICAL DEVICE COATING APPARATUS AND METHODS OF USE - Apparatus and methods are configured to coat a medical device, such as a stent, with a beneficial medicinal agent using one or more liquid feeds and one or more micromist nozzles. In one implementation, an agent coating rig includes a vertical adjustment means, a rotation means, and a traverse adjustment means for moving a medical device along virtually any point on an x or y axis. In additional or alternative implementations, the agent coating rig can further include a secondary horizontal adjustment means that allows adjustment along virtually any point on a z axis. Furthermore, methods and apparatus are provided for distributing the beneficial agent on the medical device, including delivering the beneficial agent efficiently over time. | 05-16-2013 |
20130122182 | NUTRITIONAL EMULSIONS CONTAINING ENCAPSULATED OILS - Disclosed are nutritional emulsions comprising fat, protein, and carbohydrate, including from about 0.01% to about 5% by weight of an oil having hydrophobic off-notes that is process-encapsulated by an emulsifying agent having a melt point above about 25 C, and maltodextrin having a DE of about 10 or less, wherein the weight ratio of the emulsifying agent to the process-encapsulated oil is at least about 1:15 and the weight ratio of the maltodextrin to the process-encapsulated oil is at least about 1:2. The nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils. | 05-16-2013 |
20130115355 | METHOD OF MAKING NUTRITIONAL EMULSIONS CONTAINING PROCESS- ENCAPSULATED OILS - Disclosed is a method of making nutritional emulsions, comprising: (A) heating and blending together an emulsifying agent having a melt point above about 25 C and oil having hydrophobic off-notes (e.g. non-encapsulated polyunsaturated fatty acid) in a weight ratio of at least about 1:15; (B) adding the heated blend to a fat, protein, and carbohydrate mixture comprising a maltodextrin (DE of about 10 or less), in a weight ratio of the maltodextrin to the oil having hydrophobic off-notes of at least about 1:2; and (C) homogenizing, and then cooling the combination below the melt point of the emulsifying agent to form a nutritional emulsion comprising from about 0.01% to about 5% by weight of process-encapsulated polyunsaturated fatty acid. The resulting nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils. | 05-09-2013 |
20130115344 | ULTRASONICALLY-TREATED NUTRITIONAL PRODUCTS HAVING EXTENDED SHELF LIFE - Disclosed are nutritional products and nutritional bars having increased shelf life. The nutritional product or nutritional bar is manufactured utilizing high power ultrasound in combination with an extrusion process or slabbing process. It has been found that by utilizing high power ultrasound during the manufacturing process of nutritional products and nutritional bars, that the resulting product has increased shelf life and improved texture. In some embodiments, the nutritional bars include a solid crisp matrix. | 05-09-2013 |
20130101595 | ANTIBODIES THAT BIND IL-18 AND METHODS OF INHIBITING IL-18 ACTIVITY - Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental. | 04-25-2013 |
20130096275 | VANCOMYCIN B HYDROCHLORIDE CRYSTALLINE FORM 1 - Vancomycin B Hydrochloride Crystalline Form 1, compositions containing it and methods of prevention or treatment of bacterial infections using it are disclosed. | 04-18-2013 |
20130085281 | Preparation of Pyridonecarboxylic Acid Antibacterials - A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed. | 04-04-2013 |
20130078362 | LIQUID NUTRITIONAL COMPOSITIONS CONTAINING UNSATURATED FATTY ACIDS - Disclosed are liquid nutritional compositions comprising: carbohydrate; lipid having from about 0.1% to about 20% of an n-3 polyunsaturated fatty acid, n-6 polyunsaturated fatty acid, or combinations thereof by weight of the composition; a protein matrix having from about 15% to about 50% of a whey protein fraction by weight of the total protein in the composition; and a limonene-containing material, cranberry oil, or combinations thereof. The compositions are preferably aseptically packaged, and provide enhanced oxidative stability, flavor, and aroma, especially when formulated with relative high polyunsaturated fatty acid concentrations. | 03-28-2013 |
20130066340 | VASCULAR SUTURING DEVICE - A surgical device of suturing vascular vessels is described, as well as methods for suturing tissue employing the surgical device. In one form the device includes a distal member that contains a suture and needle engaging fitting. A needle is advanced through tissue adjacent the puncture wound and into the needle engaging fitting to draw lengths of suture material which can then be used to close the puncture wound. In another form the device includes a needle advanceable through tissue and into a needle capture element within a distal end of the surgical device to draw lengths of suture material which can then be used to close various puncture wounds. In still another form the device includes at least one needle advanceable to draw lengths of suture material to close various puncture wounds. A foot is pivotal between a non-deployed and a deployed position. | 03-14-2013 |
20130060040 | Salt and Crystalline Forms Thereof of a Drug - A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed. | 03-07-2013 |
20130040407 | SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING - An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid. | 02-14-2013 |
20130031780 | Biosensor Electrode Mediators for Regeneration of Cofactors - The present invention is based on the discovery of NAD | 02-07-2013 |
20130030451 | SUTURE TRIMMER - In accordance with the present invention there is provided a suture trimmer, the suture trimmer comprising a shaft having a proximal end and a distal end and an axis therebetween, the shaft having a groove formed in the side thereof, the groove in communication with an opening formed in the side of the shaft, the opening disposed proximal the distal end. The suture trimmer further including a cutting member slidably disposed within the shaft, and a suture retainer slidably disposed within the shaft. Wherein the suture trimmer in accordance with the present invention may be additionally utilized to position knots formed within a suture loop prior to trimming the free end(s) of the suture loop. | 01-31-2013 |
20130029353 | AUTOANTIBODY ENHANCED IMMUNOASSAYS AND KITS - The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte | 01-31-2013 |
20130023555 | KINASE INHIBITOR WITH IMPROVED SOLUBILITY PROFILE - 4-Amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide which inhibits protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved aqueous solubility profile, compositions containing 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide and methods of treating diseases using 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide are disclosed. | 01-24-2013 |
20130023526 | Isoxazolines as Therapeutic Agents - The present invention provides compound of Formula (I) | 01-24-2013 |
20130023523 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 01-24-2013 |
20130023463 | HIV PROTEASE INHIBITING COMPOUNDS - A compound of the formula | 01-24-2013 |
20130018047 | N-PHENYL-(PIPERAZINYL OR HOMOPIPERAZINYL)-BENZENESULFONAMIDE OR BENZENESULFONYL-PHENYL-(PIPERAZINE OR HOMOPIPERAZINE) COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR - The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT | 01-17-2013 |
20130018045 | New Chemical Entities To Be Used For Wee1 Inhibition For The Treatment Of Cancer - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 01-17-2013 |
20130013048 | MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS - Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces. | 01-10-2013 |
20130011827 | METHODS AND KITS FOR DECREASING INTERFERENCES IN PLASMA OR SERUM CONTAINING ASSAY SAMPLES OF SPECIFIC BINDING ASSAYS - Methods and kits are provided for decreasing interferences and inaccuracies due to nonoptimal sample handling of blood samples in plasma or serum containing assay samples of specific binding assays by addition of a large polycation to the assay sample during the specific binding assay. | 01-10-2013 |
20130011826 | METHODS AND KITS FOR DECREASING INTERFERENCES FROM LEUKOCYTES IN SPECIFIC BINDING ASSAYS - The present disclosure describes methods and kits for reducing interferences in immunoassays performed on solid phase and on samples containing serum or plasma, by adding an effective amount of a polycationic derivative of dextran to the assay. | 01-10-2013 |
20130011498 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR REDUCING TUMOR GROWTH RATE - The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids. | 01-10-2013 |
20130006277 | SUTURING DEVICE WITH SPLIT ARM AND METHOD OF SUTURING TISSUE - A device for suturing an opening in a tissue, having an elongated shaft, at least two arms movable to a deployed positioning which the arms are non-perpendicular to the shaft, the arms having needle receiving portions; and needles advanceable longitudinally along the shaft toward the needle receiving portions, the needles exiting through side walls of the shaft at a location proximal to the arms. | 01-03-2013 |
20130006274 | CLIP APPLIER AND METHODS OF USE - An apparatus for placement into an opening formed in a wall of a body lumen to deploy a closure element. The apparatus comprising a housing having a handle portion formed at a distal end, the handle portion configured to be engaged by a user when advancing the housing to deploy the closure element. A locator assembly and a carrier assembly are at least partially received in the housing. The locator assembly can have one or more expansion members that can selectably contact the wall of the body lumen and a proximal end configured to cooperate with a portion of a locator control system operable to expand the one or more expansion members. A triggering system cooperates with the locator assembly and is moveable toward the one or more expansion members of the locator assembly upon the locator control system being operated to expand the one or more expansion members. | 01-03-2013 |
20130004416 | Dual Variable Domain Immunoglobulin and Uses Thereof - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases. | 01-03-2013 |
20130001192 | METHOD OF REDUCING RIGIDITY OF ANGIOPLASTY BALLOON SECTIONS - A dilatation balloon is fabricated according to a process that forms cavities and indentations in the balloon and/or catheter sections. A length of tubing is axially elongated and radially expanded in a form to provide the requisite biaxial orientation and strength. Then, an excimer laser or another type of laser or mechanical material removal tool is used to remove the polymeric material, virtually without thermal effects. Cavities in the sleeve sections of the balloon are defined and if desired, indentations in the cone sections are defined. Material removal, particularly near the balloon sleeves enables a thinner, more flexible bonding area between the catheter shaft and the balloon. Further, the indentations along the cone sections enables tighter wrapping of the balloon for a reduced delivery profile. Rigidity near the sleeves is reduced for better maneuverability of the catheter in tortuous passageways. | 01-03-2013 |
20120330012 | Novel Tricyclic Compounds - The invention provides compounds of Formula (I) | 12-27-2012 |
20120329772 | AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE - A compound having Formula (I) or Formula (II) | 12-27-2012 |
20120329176 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME - Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided. | 12-27-2012 |
20120325770 | Bottle For Flowable Product - A bottle has a body intermediate a neck and a closed bottom of the bottle. The body has an exterior surface defining a circumference of the body. The body includes a plurality of panel segments. Each panel segment has an upper panel end, a lower panel end, a length extending from the upper panel end to the lower panel end, opposite longitudinal sides, and a panel centerline extending at a substantially constant acute angle relative to the longitudinal axis of the bottle. The panel segments are disposed generally side-by-side around the circumference of the body. The exterior surface of each panel segment may be substantially planar along the circumferential width of the panel segment. | 12-27-2012 |
20120323093 | Article and Method for Applying a Coupling Agent for a Non-Invasive Optical Probe - An article of manufacture and method for controlling the application of a coupling agent, such as a silicone oil or mineral oil, on a surface of a tissue prior to contacting the tissue with an apparatus for non-invasive optical measurement of the concentration of an analyte. The article ensures that a specific quantity of the coupling agent is deposited in a uniform layer over the entire target area of the tissue, thereby enhancing both the optical signal and the repeatability of thermal and optical coupling with the components of the apparatus. | 12-20-2012 |
20120316579 | ARTICULATING SUTURING DEVICE AND METHOD - Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot of the device can be inserted through the penetration and actuated so that the foot extends along the lumenal axis. The foot can carry suturing attachment cuffs with one end of the cuff adapted to receive a needle, while the other end receives suture. A portion of the foot and/or lumen of the shaft can receive a portion of the suture and can include friction reducing structure that aid with movement of the sutured during removal of the cuffs from within the penetration. | 12-13-2012 |
20120316153 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY - The present invention relates to benzazepine derivatives of the formula (I) | 12-13-2012 |
20120315376 | Method And System To Maintain A Fixed Distance During Coating Of A Medical Device - Method and system to coat an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A tracking mechanism maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the at least one outlet relative to the expandable member. | 12-13-2012 |
20120315375 | Maintaining A Fixed Distance By Providing An Air Cushion During Coating Of A Medical Device - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member. | 12-13-2012 |
20120315374 | Maintaining A Fixed Distance By Laser Or Sonar Assisted Positioning During Coating Of A Medical Device - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device is provided to determine the distance to the surface of the expandable member at a corresponding location and relays the information to a controller or the like to maintain a substantially fixed distance between the outlet of the applicator and the surface of the expandable member when in alignment with the corresponding location. | 12-13-2012 |
20120312684 | Multiple-Biosensor Article - An article suitable for conducting one or more assays with an apparatus, e.g., a meter, for determining the presence or concentration of an analyte in a sample of biological fluid. The article contains a plurality of biosensors arranged in such a manner that each of the biosensors can be utilized before the article must be removed from the apparatus. | 12-13-2012 |
20120309783 | KINASE INHIBITORS WITH IMPROVED CYP SAFETY PROFILE - Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. | 12-06-2012 |
20120309762 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF - The present invention features compounds of formula I | 12-06-2012 |
20120309740 | Pharmaceutical Compositions Having Improved Dissolution Profiles For Poorly Soluble Drugs - Pharmaceutical compositions having improved dissolution profiles for drugs therein is disclosed. | 12-06-2012 |
20120308997 | SPATIALLY RESOLVED LIGAND-RECEPTOR BINDING ASSAYS - A method for analyzing the results of a ligand-receptor binding assay comprising the steps of:
| 12-06-2012 |
20120308435 | SYSTEM, APPARATUS, AND METHOD FOR CLOSED TUBE SAMPLING AND OPEN TUBE SAMPLING FOR AUTOMATED CLINICAL ANALYZERS - A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge. | 12-06-2012 |
20120305507 | SPECIMEN SAMPLE RACK - A rack for a plurality of capped tubes, including a frame having a longitudinally extending bottom base member having a row of spaced open top recesses adapted to receive the capped tubes. Vertical supports at the ends of the row of recesses fix a cover member above the base member. The cover member has openings therethrough smaller than the capped tubes. A wall is along one longitudinal side between the base member and the cover member, with the other longitudinal side between the base member and the cover member being open. Support fingers extend horizontally from the wall toward the open longitudinal side and are vertically aligned between the recesses to secure capped tubes in a generally vertical direction in a longitudinally extending vertical plane. The base member and cover member are vertically spaced a distance sufficient to permit tipped capped tubes to be moved into the frame with the tipped tubes then dropped into the recesses and tipped back to an upright vertical position. | 12-06-2012 |