ADENOVIRUS POLYNUCLEOTIDES AND POLYPEPTIDES

Abstract

There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a Continuation of copending U.S. application Ser. No. 15/735,872 filed Dec. 12, 2017, which is the National Phase under 35 U.S.C. .sctn. 371 of International Application No. PCT/EP2016/063297, filed on Jun. 10, 2016, which claims the benefit under 35 U.S.C. .sctn. 119(a) to Patent Application No. PCT/EP2015/063248, filed in European Patent Office on Jun. 12, 2015, Patent Application No. 1514772.1, filed in United Kingdom on Aug. 19, 2015, and Patent Application No. 1510357.5, filed in United Kingdom on Jun. 12, 2015, all of which are hereby expressly incorporated by reference into the present application.

FIELD OF THE INVENTION

[0002] The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimp adenovirus ChAd155, as well as to recombinant polynucleotides, vectors, adenoviruses and compositions comprising said polynucleotide and polypeptide sequences.

BACKGROUND OF THE INVENTION

[0003] Adenovirus has been widely used for gene transfer applications due to its ability to achieve highly efficient gene transfer in a variety of target tissues and large transgene capacity. Conventionally, E1 genes of adenovirus are deleted and replaced with a transgene cassette consisting of the promoter of choice, cDNA sequence of the gene of interest and a poly A signal, resulting in a replication defective recombinant virus.

[0004] Recombinant adenoviruses are useful in gene therapy and as vaccines. Viral vectors based on chimpanzee adenovirus represent an alternative to the use of human derived Ad vectors for the development of genetic vaccines. Adenoviruses isolated from chimpanzees are closely related to adenoviruses isolated from humans as demonstrated by their efficient propagation in cells of human origin. However, since human and chimp adenoviruses are close relatives, serologic cross reactivity between the two virus species is possible.

[0005] There is a demand for vectors which effectively deliver molecules to a target and minimize the effect of pre-existing immunity to selected adenovirus serotypes in the population. One aspect of pre-existing immunity that is observed in humans is humoral immunity, which can result in the production and persistence of antibodies that are specific for adenoviral proteins. The humoral response elicited by adenovirus is mainly directed against the three major structural capsid proteins: fiber, penton and hexon.

[0006] Vectors, compositions and methods of the present invention may have one or more following improved characteristics over the prior art, including but not limited to higher productivity, improved immunogenicity and increased transgene expression. Vectors of the present invention may find use in the expression of one or more immunogens useful to immunise a human or non-human animal against a pathogen.

[0007] Respiratory syncytial virus (RSV) is a highly contagious human pathogen that causes respiratory tract infections in people of all ages. During the first year of life, 50-70% of infants are infected with RSV and essentially all children have had an RSV infection by their second birthday. The risk for severe RSV-associated lower respiratory tract infections (LRTI) is highest in infants below 6 months of age and is a leading cause for hospitalization. Infection with RSV does not confer full protective immunity. Symptomatic RSV re-infections are common later in life and continue throughout adulthood. These re-infections generally go undiagnosed because they usually present as common acute upper respiratory tract infections. In more vulnerable persons (e.g., immunocompromised adults or elderly), re-infections can however also lead to severe disease.

[0008] To date, no vaccine is available against RSV and treatment of RSV disease is largely symptomatic and supportive care. The antiviral drug ribavirin is currently the only approved antiviral therapy for RSV treatment, but its use is restricted to severe hospitalized cases due to uncertainties regarding its efficacy, difficulty in administration (aerosol) and high cost [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis, 2006]. RSV-specific monoclonal antibodies (palivizumab, Synagis.TM., Medimmune) are indicated for the prevention of serious LRTIs requiring hospitalization caused by RSV in children at high risk for RSV disease but are not indicated or recommended in the general, healthy infant population due to high cost and the need for repeated administration.

[0009] In the late 1960s, a formalin-inactivated whole virus RSV vaccine (FI-RSV) tested in clinical trials led to more severe clinical symptoms upon subsequent natural infection with RSV in children under the age of two [Kim, 1969; Chin, 1969]). This experience has led to heightened safety concerns with pediatric RSV vaccine candidates. Since that time, several investigational vaccines have been and continue to be explored, including live attenuated viral vaccines and those based upon purified or recombinant viral proteins. However there is not yet a licensed vaccine for the prevention of RSV disease.

SUMMARY OF THE INVENTION

[0010] There is provided an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of:

[0011] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0012] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and

[0013] (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0014] Also provided is a recombinant polynucleotide comprising a polynucleotide selected from the group consisting of:

[0015] (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0016] (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and

[0017] (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0018] Also provided is a recombinant vector comprising a polynucleotide selected from the group consisting of:

[0019] (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0020] (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and

[0021] (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0022] Also provided is a recombinant adenovirus comprising at least one polynucleotide or polypeptide selected from the group consisting of:

[0023] (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0024] (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1,

[0025] (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3,

[0026] (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0027] (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and

[0028] (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0029] Also provided is a composition comprising at least one of the following:

[0030] (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0031] (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1,

[0032] (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3,

[0033] (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0034] (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1,

[0035] (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3,

[0036] (g) a vector comprising a polynucleotide as described in (a), (b) or (c) above, and

[0037] (h) a recombinant adenovirus comprising a polynucleotide as described in (a), (b) or (c) above, and a pharmaceutically acceptable excipient.

[0038] Also provided is a cell comprising at least one of the following:

[0039] (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0040] (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1,

[0041] (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3,

[0042] (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0043] (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1,

[0044] (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3,

[0045] (g) a vector comprising a polynucleotide as described in (a), (b) or (c) above, and

[0046] (h) a recombinant adenovirus comprising a polynucleotide as described in (a), (b) or (c) above.

[0047] Also provided is an isolated adenoviral polypeptide selected from the group consisting of:

[0048] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,

[0049] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and

[0050] (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0051] Also provided is an isolated polynucleotide, vector, recombinant adenovirus, composition or cell comprising or consisting of the sequence according to SEQ ID NO: 6.

DESCRIPTION OF THE FIGURES

[0052] FIG. 1A-C--Alignment of fiber protein sequences from the indicated simian adenoviruses.

[0053] ChAd3 (SEQ ID NO:27)

[0054] PanAd3 (SEQ ID NO:28)

[0055] ChAd17 (SEQ ID NO:29)

[0056] ChAd19 (SEQ ID NO:30)

[0057] ChAd24 (SEQ ID NO:31)

[0058] ChAd155 (SEQ ID NO:1)

[0059] ChAd11 (SEQ ID NO:32)

[0060] ChAd20 (SEQ ID NO:33)

[0061] ChAd31 (SEQ ID NO:34)

[0062] PanAd1 (SEQ ID NO:35)

[0063] PanAd2 (SEQ ID NO:36)

[0064] FIG. 2--Flow diagram for production of specific ChAd155 BAC and plasmid vectors

[0065] FIG. 3--Species C BAC Shuttle #1365 schematic

[0066] FIG. 4--pArsChAd155 Ad5E4orf6-2 (#1490) schematic

[0067] FIG. 5--pChAd155/RSV schematic

[0068] FIG. 6--BAC ChAd155/RSV schematic

[0069] FIG. 7--Productivty of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene (Experiment 1)

[0070] FIG. 8--Productivity of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene (Experiment 2)

[0071] FIG. 9--Productivity of PanAd3 and ChAd155 vectors expressing RSV transgene

[0072] FIG. 10--Expression levels of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene

[0073] FIG. 11--Expression levels of PanAd3 and ChAd155 vectors expressing an HIV Gag transgene--Western Blot

[0074] FIG. 12--Immunogenicity of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene--IFN-gamma ELISpot

[0075] FIG. 13--Immunogenicity of PanAd3 and ChAd155 vectors expressing an HIV Gag transgene--IFN-gamma ELISpot

[0076] FIG. 14--Schematic of the synthetic DNA fragment used to express RSV antigens by the ChAd155-RSV vector

[0077] FIG. 15--Anti-F antibody titers induced by ChAd155-RSV and PanAd3-RSV in BALB/c mice

[0078] FIG. 16--RSV titers in nasal tissues (A) and lung homogenates (B), RSV neutralizing antibody (C) and pathology score (D) after viral challenge

[0079] FIG. 17--Kinetics of induction of bRSV-specific IgG (A) and RSV neutralizing antibodies (B)

[0080] FIG. 18--Kinetics of mean virus titers in nasopharyngeal swabs detected up to day 6 post bRSV challenge

[0081] FIG. 19--Effect of vaccination on bRSV replication in the lower respiratory tract

[0082] FIG. 20--Effect of vaccination on gross pneumonic consolidation 6 days post bRSV challenge

[0083] FIG. 21--Effect of vaccination on the pulmonary inflammatory response 6 days post bRSV challenge

DESCRIPTION OF THE SEQUENCES

[0084] SEQ ID NO: 1--Polypeptide sequence of ChAd155 fiber

[0085] SEQ ID NO: 2--Polynucleotide sequence encoding ChAd155 fiber

[0086] SEQ ID NO: 3--Polypeptide sequence of ChAd155 penton

[0087] SEQ ID NO: 4--Polynucleotide sequence encoding ChAd155 penton

[0088] SEQ ID NO: 5--Polypeptide sequence of ChAd155 hexon

[0089] SEQ ID NO: 6--Polynucleotide sequence encoding ChAd155 hexon

[0090] SEQ ID NO: 7--Polynucleotide sequence encoding ChAd155#1434

[0091] SEQ ID NO: 8--Polynucleotide sequence encoding ChAd155#1390

[0092] SEQ ID NO: 9--Polynucleotide sequence encoding ChAd155#1375

[0093] SEQ ID NO: 10--Polynucleotide sequence encoding wild type ChAd155

[0094] SEQ ID NO: 11--Polynucleotide sequence encoding ChAd155/RSV

[0095] SEQ ID NO: 12--Polynucleotide sequence encoding the CASI promoter

[0096] SEQ ID NO: 13--Ad5orf6 primer 1 polynucleotide sequence

[0097] SEQ ID NO: 14--Ad5orf6 primer 2 polynucleotide sequence

[0098] SEQ ID NO: 15--BAC/CHAd155 .DELTA.E1_TetO hCMV RpsL-Kana primer 1 polynucleotide sequence

[0099] SEQ ID NO: 16--BAC/CHAd155 .DELTA.E1_TetO hCMV RpsL-Kana (#1375) primer 2 polynucleotide sequence

[0100] SEQ ID NO: 17--1021-FW E4 Del Step1 primer polynucleotide sequence

[0101] SEQ ID NO: 18--1022-RW E4 Del Step1 primer polynucleotide sequence

[0102] SEQ ID NO: 19--1025-FW E4 Del Step2 primer polynucleotide sequence

[0103] SEQ ID NO: 20--1026-RW E4 Del Step2 primer polynucleotide sequence

[0104] SEQ ID NO: 21--91-SubMonte FW primer polynucleotide sequence

[0105] SEQ ID NO: 22--890-BghPolyA RW primer polynucleotide sequence

[0106] SEQ ID NO: 23--CMVfor primer polynucleotide sequence

[0107] SEQ ID NO: 24--CMVrev primer polynucleotide sequence

[0108] SEQ ID NO: 25--CMVFAM-TAMRA qPCR probe polynucleotide sequence

[0109] SEQ ID NO: 26--Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) polynucleotide sequence

[0110] SEQ ID NO: 27--Amino acid sequence for the fiber protein of ChAd3

[0111] SEQ ID NO: 28--Amino acid sequence for the fiber protein of PanAd3

[0112] SEQ ID NO: 29--Amino acid sequence for the fiber protein of ChAd17

[0113] SEQ ID NO: 30--Amino acid sequence for the fiber protein of ChAd19

[0114] SEQ ID NO: 31--Amino acid sequence for the fiber protein of ChAd24

[0115] SEQ ID NO: 32--Amino acid sequence for the fiber protein of ChAd11

[0116] SEQ ID NO: 33--Amino acid sequence for the fiber protein of ChAd20

[0117] SEQ ID NO: 34--Amino acid sequence for the fiber protein of ChAd31

[0118] SEQ ID NO: 35--Amino acid sequence for the fiber protein of PanAd1

[0119] SEQ ID NO: 36--Amino acid sequence for the fiber protein of PanAd2

[0120] SEQ ID NO: 37--RSV F.DELTA.TM-N-M2-1 amino acid sequence

[0121] SEQ ID NO: 38--HIV Gag polynucleotide sequence

DETAILED DESCRIPTION OF THE INVENTION

[0122] Adenovirus

[0123] Adenoviruses have a characteristic morphology with an icosahedral capsid comprising three major proteins, hexon (II), penton base (III) and a knobbed fiber (IV), along with a number of other minor proteins, VI, VIII, IX, IIIa and IVa2. The virus genome is a linear, double-stranded DNA. The virus DNA is intimately associated with the highly basic protein VII and a small peptide pX (formerly termed mu). Another protein, V, is packaged with this DNA-protein complex and provides a structural link to the capsid via protein VI. The virus also contains a virus-encoded protease, which is necessary for processing of some of the structural proteins to produce mature infectious virus.

[0124] The adenoviral genome is well characterized. There is general conservation in the overall organization of the adenoviral genome with respect to specific open reading frames being similarly positioned, e.g. the location of the E1A, E1B, E2A, E2B, E3, E4, L1, L2, L3, L4 and L5 genes of each virus. Each extremity of the adenoviral genome comprises a sequence known as an inverted terminal repeat (ITR), which is necessary for viral replication. The virus also comprises a virus-encoded protease, which is necessary for processing some of the structural proteins required to produce infectious virions. The structure of the adenoviral genome is described on the basis of the order in which the viral genes are expressed following host cell transduction. More specifically, the viral genes are referred to as early (E) or late (L) genes according to whether transcription occurs prior to or after onset of DNA replication. In the early phase of transduction, the E1A, E1B, E2A, E2B, E3 and E4 genes of adenovirus are expressed to prepare the host cell for viral replication. During the late phase of infection, expression of the late genes L1-L5, which encode the structural components of the virus particles, is activated.

[0125] Adenoviruses are species-specific and different serotypes, i.e., types of viruses that are not cross-neutralized by antibodies, have been isolated from a variety of mammalian species. For example, more than 50 serotypes have been isolated from humans which are divided into six subgroups (A-F; B is subdivided into B1 and B2) based on sequence homology and on their ability to agglutinate red blood cells (Tatsis and Ertl Molecular Therapy (2004) 10:616-629). Numerous adenoviruses have been isolated from nonhuman simians such as chimpanzees, bonobos, rhesus macaques and gorillas, and they are classified into the same human groups based on phylogenetic relationships based on hexon or fiber sequences (Colloca et al. (2012) Science Translational Medicine 4:1-9; Roy et al. (2004) Virology 324: 361-372; Roy et al. (2010) Journal of Gene Medicine 13:17-25).

[0126] Adenovirus Capsid Proteins including the Fiber Protein and Polynucleotides Encoding these Proteins

[0127] As outlined above, the adenoviral capsid comprises three major proteins, hexon, penton and fiber. The hexon accounts for the majority of the structural components of the capsid, which consists of 240 trimeric hexon capsomeres and 12 penton bases. The hexon has three conserved double barrels, while the top has three towers, each tower containing a loop from each subunit that forms most of the capsid. The base of hexon is highly conserved between adenoviral serotypes, while the surface loops are variable (Tatsis and Ertl Molecular Therapy (2004) 10:616-629).

[0128] Penton is another adenoviral capsid protein that forms a pentameric base to which fiber attaches. The trimeric fiber protein protrudes from the penton base at each of the 12 vertices of the capsid and is a knobbed rod-like structure. A remarkable difference in the surface of adenovirus capsids compared to that of most other icosahedral viruses is the presence of the long, thin fiber protein. The primary role of the fiber protein is the tethering of the viral capsid to the cell surface via its interaction with a cellular receptor.

[0129] The fiber proteins of many adenovirus serotypes share a common architecture: an N-terminal tail, a central shaft made of repeating sequences, and a C-terminal globular knob domain (or "head"). The central shaft domain consists of a variable number of beta-repeats. The beta-repeats connect to form an elongated structure of three intertwined spiralling strands that is highly rigid and stable. The shaft connects the N-terminal tail with the globular knob structure, which is responsible for interaction with the target cellular receptor. The globular nature of the adenovirus knob domain presents large surfaces for binding the receptor laterally and apically. The effect of this architecture is to project the receptor-binding site far from the virus capsid, thus freeing the virus from steric constraints presented by the relatively flat capsid surface.

[0130] Although fibers of many adenovirus serotypes have the same overall architecture, they have variable amino acid sequences that influence their function as well as structure. For example, a number of exposed regions on the surface of the fiber knob present an easily adaptable receptor binding site. The globular shape of the fiber knob allows receptors to bind at the sides of the knob or on top of the fiber knob. These binding sites typically lie on surface-exposed loops connecting beta-strands that are poorly conserved among human adenoviruses. The exposed side chains on these loops give the knob a variety of surface features while preserving the tertiary and quaternary structure. For example, the electrostatic potential and charge distributions at the knob surfaces can vary due to the wide range of isoelectric points in the fiber knob sequences, from pl approximately 9 for Ad 8, Ad 19, and Ad 37 to approximately 5 for subgroup B adenoviruses. As a structurally complex virus ligand, the fiber protein allows the presentation of a variety of binding surfaces (knob) in a number of orientations and distances (shaft) from the viral capsid.

[0131] One of the most obvious variations between some serotypes is fiber length. Studies have shown that the length of the fiber shaft strongly influences the interaction of the knob and the virus with its target receptors. Further, fiber proteins between serotypes can also vary in their ability to bend. Although beta-repeats in the shaft form a highly stable and regular structure, electron microscopy (EM) studies have shown distinct hinges in the fiber. Analysis of the protein sequence from several adenovirus serotype fibers pinpoints a disruption in the repeating sequences of the shaft at the third beta-repeat from the N-terminal tail, which correlates strongly with one of the hinges in the shaft, as seen by EM. The hinges in the fiber allow the knob to adopt a variety of orientations relative to the virus capsid, which may circumvent steric hindrances to receptor engagement requiring the correct presentation of the receptor binding site on the knob. For example, the rigid fibers of subgroup D Ads thus require a flexible receptor or one prepositioned for virus attachment, as they are unable to bend themselves. (Nicklin et al Molecular Therapy 2005 12:384-393)

[0132] The identification of specific cell receptors for different Ad serotypes and the knowledge of how they contribute to tissue tropism have been achieved through the use of fiber pseudotyping technology. Although Ads of some subgroups use CAR as a primary receptor, it is becoming clear that many Ads use alternate primary receptors, leading to vastly different tropism in vitro and in vivo. The fibers of these serotypes show clear differences in their primary and tertiary structures, such as fiber shaft rigidity, the length of the fiber shaft, and the lack of a CAR binding site and/or the putative HSPG binding motif, together with the differences in net charge within the fiber knob. Pseudotyping Ad 5 particles with an alternate fiber shaft and knob therefore provides an opportunity to remove important cell binding domains and, in addition, may allow more efficient (and potentially more cell-selective) transgene delivery to defined cell types compared to that achieved with Ad 5. Neutralization of fiber-pseudotyped Ad particles may also be reduced if the fibers used are from Ads with lower seroprevalence in humans or experimental models, a situation that favours successful administration of the vector (Nicklin et al Molecular Therapy (2005) 12:384-393). Furthermore, full length fiber as well as isolated fiber knob regions, but not hexon or penton alone, are capable of inducing dendritic cell maturation and are associated with induction of a potent CD8+ T cell response (Molinier-Frenkel et al. J. Biol. Chem. (2003) 278:37175-37182). Taken together, adenoviral fiber plays an important role in at least receptor-binding and immunogenicity of adenoviral vectors.

[0133] Illustrating the differences between the fiber proteins of Group C simian adenoviruses is the alignment provided in FIG. 1. A striking feature is that the fiber sequences of these adenoviruses can be broadly grouped into having a long fiber, such as ChAd155, or a short fiber, such as ChAd3. This length differential is due to a 36 amino acid deletion at approximately position 321 in the short fiber relative to the long fiber. In addition, there are a number of amino acid substitutions that differ between the short versus long fiber subgroup yet are consistent within each subgroup. While the exact function of these differences have not yet been elucidated, given the function and immunogenicity of fiber, they are likely to be significant. It has been shown that one of the determinants of viral tropism is the length of the fiber shaft. It has been demonstrated that an Ad5 vector with a shorter shaft has a lower efficiency of binding to CAR receptor and a lower infectivity (Ambriovi -Ristov A. et al.: Virology. (2003) 312(2):425-33): It has been speculated that this impairment is the results of an increased rigidity of the shorter fiber leading to a less efficient attachment to the cell receptor (Wu, E et al.: J Virol. (2003) 77(13): 7225-7235). These studies may explain the improved properties of ChAd155 carrying a longer and more flexible fiber in comparison with the previously described ChAd3 and PanAd3 carrying a fiber with a shorter shaft.

[0134] In one aspect of the invention there is provided isolated fiber, penton and hexon capsid polypeptides of chimp adenovirus ChAd155 and isolated polynucleotides encoding the fiber, penton and hexon capsid polypeptides of chimp adenovirus ChAd155.

[0135] All three capsid proteins are expected to contribute to low seroprevalence and can, thus, be used independently from each other or in combination to suppress the affinity of an adenovirus to preexisting neutralizing antibodies, e.g. to manufacture a recombinant adenovirus with a reduced seroprevalence. Such a recombinant adenovirus may be a chimeric adenovirus with capsid proteins from different serotypes with at least a fiber protein from ChAd155.

[0136] The ChAd155 fiber polypeptide sequence is provided in SEQ ID NO: 1.

[0137] The ChAd155 penton polypeptide sequence is provided in SEQ ID NO: 3.

[0138] The ChAd155 hexon polypeptide sequence is provided in SEQ ID NO: 5.

[0139] Polypeptides, Recombinant Adenoviruses, Compositions or Cells comprising Polypeptide Sequences of ChAd155 Fiber or a Functional Derivative thereof

[0140] Suitably the isolated polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide having the amino acid sequence according to SEQ ID NO: 1.

[0141] Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide which is a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 80% identical, such as at least 85.0% identical, such as at least 90% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99.2% identical, such as at least 99.4% identical, such as 99.5% identical, such as at least 99.6% identical, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1.

[0142] Suitably the polypeptide, recombinant adenovirus, composition or cell according to the invention further comprises:

[0143] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 3; or

[0144] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3, wherein the functional derivative has an amino acid sequence which is at least 50.0% identical over its entire length to the amino acid sequence of SEQ ID NO: 3, and/or

[0145] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or

[0146] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5.

[0147] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 3. Alternatively the functional derivative has no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 3.

[0148] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5.

[0149] Polypeptides, Recombinant Adenoviruses, Compositions or Cells comprising Polypeptide Sequences of ChAd155 Penton

[0150] Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

[0151] Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention further comprises:

[0152] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1; or

[0153] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1 and/or

[0154] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or

[0155] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 60% identical over its entire length to the amino acid sequence of SEQ ID NO: 5.

[0156] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 60.0% identical, such as at least 70.0% identical, such as at least 80.0% identical, such as at least 85.0% identical, such as at least 87.0% identical, such as at least 89.0% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1.

[0157] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 99.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO:5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5.

[0158] Isolated Polynucleotides, Vectors, Recombinant Adenoviruses, Compositions or Cells comprising Polynucleotides Encoding ChAd155 Fiber or a Functional Derivative thereof

[0159] Suitably the isolated polynucleotide, vector, recombinant adenovirus, thereof composition or cell of the invention comprises a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1. Suitably the polynucleotide has a sequence according to SEQ ID NO: 2.

[0160] Alternatively, the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention comprises a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 80% identical, such as at least 85.0% identical, such as at least 90% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99% identical, such as at least 99.4% identical, such as at least 99.6% identical, such as at least 99.8% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1.

[0161] Suitably the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention further comprises a polynucleotide encoding:

[0162] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 3; or

[0163] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3, wherein the functional derivative has an amino acid sequence which is at least 50.0% identical over its entire length to the amino acid sequence of SEQ ID NO: 3, and/or

[0164] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or

[0165] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5.

[0166] Suitably the functional derivative of the polypeptide having the amino acid sequence according to SEQ ID NO: 3 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99%, such as at least 99.4%, such as at least 99.6%, such as at least 99.8% identical over its entire length to the amino acid sequence of SEQ ID NO: 3. Alternatively the functional derivative has no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 3.

[0167] Suitably the functional derivative of the polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 98.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5.

[0168] Isolated Polynucleotides, Vectors, Recombinant Adenoviruses, Compositions or Cells comprising Polynucleotides Encoding ChAd155 Penton

[0169] Suitably the isolated polynucleotide, vector, recombinant adenovirus, composition or cell of the invention comprises a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3. Suitably the polynucleotide has a sequence according to SEQ ID NO: 4.

[0170] Suitably the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention further comprises a polynucleotide encoding:

[0171] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1; or

[0172] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 1 and/or

[0173] (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or

[0174] (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5.

[0175] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 60.0% identical, such as at least 70.0% identical, such as at least 80.0% identical, such as at least 85.0% identical, such as at least 87.0% identical, such as at least 89.0% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1.

[0176] Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 98.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5.

[0177] ChAd155 Backbones

[0178] The invention provides isolated polynucleotide sequences of chimp adenovirus ChAd155, including that of wild type, unmodified ChAd155 (SEQ ID NO: 10) and modified backbone constructs of ChAd155. These modified backbone constructs include ChAd155#1434 (SEQ ID NO: 7), ChAd155#1390 (SEQ ID NO: 8) and ChAd155#1375 (SEQ ID NO: 9). ChAd155 backbones may be used in the construction of recombinant replication-competent or replication-incompetent adenoviruses for example for the delivery of transgenes.

[0179] Annotation of the ChAd155 wild type sequence (SEQ ID NO: 10) sequence is provided below.

TABLE-US-00001 LOCUS ChAd155 37830 bp DNA linear 10-JUN-2015 DEFINITION Chimp adenovirus 155, complete genome. COMMENT Annotation according to alignment of ChAd155 against the human Adenovirus 2 reference strain NC_001405 Two putative ORFs in the E3 region added manually FEATURES Location/Qualifiers source 1 . . . 37830 /organism = "Chimpanzee adenovirus 155" /mol_type = "genomic DNA" /acronym = "ChAd155" repeat_region 1 . . . 101 /standard_name = "ITR" /rpt_type = inverted gene 466 . . . 1622 /gene = "E1A" TATA_signal 466 . . . 471 /gene = "E1A" prim_transcript 497 . . . 1622 /gene = "E1A" CDS join(577 . . . 1117, 1231 . . . 1532) /gene = "E1A" /product = "E1A_280R" CDS join(577 . . . 979, 1231 . . . 1532) /gene = "E1A" /product = "E1A_243R" polyA_signal 1600 . . . 1605 /gene = "E1A" gene 1662 . . . 4131 /gene = "E1B" TATA_signal 1662 . . . 1667 /gene = "E1B" prim_transcript 1692 . . . 4131 /gene = "E1B" CDS 1704 . . . 2267 /gene = "E1B" /product = "E1B_19K" CDS 2009 . . . 3532 /gene = "E1B" /product = "E1B_55K" gene 3571 . . . 4131 /gene = "IX" TATA_signal 3571 . . . 3576 /gene = "IX" prim_transcript 3601 . . . 4131 /gene = "IX" CDS 3628 . . . 4092 /gene = "IX" /product = "IX" polyA_signal 4097 . . . 4102 /note = "E1B, IX" gene complement(4117 . . . 27523) /gene = "E2B" prim_transcript complement(4117 . . . 27494) /gene = "E2B" gene complement(4117 . . . 5896) /gene = "IVa2" prim_transcript complement(4117 . . . 5896) /gene = "IVa2" CDS complement(join(4151 . . . 5487, 5766 . . . 5778)) /gene = "IVa2" /product = "E2B_IVa2" polyA_signal complement(4150 . . . 4155) /note = "IVa2, E2B" CDS complement(join(5257 . . . 8838, 14209 . . . 14217)) /gene = "E2B" /product = "E2B_polymerase" gene 6078 . . . 34605 /gene = "L5" gene 6078 . . . 28612 /gene = "L4" gene 6078 . . . 22658 /gene = "L3" gene 6078 . . . 18164 /gene = "L2" gene 6078 . . . 14216 /gene = "L1" TATA_signal 6078 . . . 6083 /note = "L" prim_transcript 6109 . . . 34605 /gene = "L5" prim_transcript 6109 . . . 28612 /gene = "L4" prim_transcript 6109 . . . 22658 /gene = "L3" prim_transcript 6109 . . . 18164 /gene = "L2" prim_transcript 6109 . . . 14216 /gene = "L1" CDS join(8038 . . . 8457, 9722 . . . 9742) /gene = "L1" /product = "L1_13.6K" CDS complement(join(8637 . . . 10640, 14209 . . . 14217)) /gene = "E2B" /product = "E2B_pTP" gene 10671 . . . 10832 /gene = "VAI" misc_RNA 10671 . . . 10832 /gene = "VAI" /product = "VAI" gene 10902 . . . 11072 /gene = "VAII" misc_RNA 10902 . . . 11072 /gene = "VAII" /product = "VAII" CDS 11093 . . . 12352 /gene = "L1" /product = "L1_52K" CDS 12376 . . . 14157 /gene = "L1" /product = "L1_pIIIa" polyA_signal 14197 . . . 14202 /gene = "L1" CDS 14254 . . . 16035 /gene = "L2" /product = "L2_penton" CDS 16050 . . . 16646 /gene = "L2" /product = "L2_pVII" CDS 16719 . . . 17834 /gene = "L2" /product = "L2_V" CDS 17859 . . . 18104 /gene = "L2" /product = "L2_pX" polyA_signal 18143 . . . 18148 /gene = "L2" CDS 18196 . . . 18951 /gene = "L3" /product = "L3_pVI" CDS 19063 . . . 21945 /gene = "L3" /product = "L3_hexon" CDS 21975 . . . 22604 /gene = "L3" /product = "L3_protease" polyA_signal 22630 . . . 22635 /gene = "L3" gene complement(22632 . . . 27523) /gene = "E2A" prim_transcript complement(22632 . . . 27494) /gene = "E2A" gene complement(22632 . . . 26357) /gene = "E2A-L" prim_transcript complement(22632 . . . 26328) /gene = "E2A-L" polyA_signal complement(22649 . . . 22654) /note = "E2A, E2A-L" CDS complement(22715 . . . 24367) /gene = "E2A" /note = "DBP; genus-common; DBP family" /codon_start = 1 /product = "E2A" CDS 24405 . . . 26915 /gene = "L4" /product = "L4_100k" TATA_signal complement(26352 . . . 26357) /gene = "E2A-L" CDS join(26602 . . . 26941, 27147 . . . 27529) /gene = "L4" /product = "L4_33K" CDS 26602 . . . 27207 /gene = "L4" /product = "L4_22K" TATA_signal complement(27518 . . . 27523) /note = "E2A, E2B; nominal" CDS 27604 . . . 28287 /gene = "L4" /product = "L4_pVIII" gene 27969 . . . 32686 /gene = "E3B" gene 27969 . . . 31611 /gene = "E3A" TATA_signal 27969 . . . 27974 /note = "E3A, E3B" prim_transcript 27998 . . . 32686 /gene = "E3B" prim_transcript 27998 . . . 31611 /gene = "E3A"

CDS 28288 . . . 28605 /gene = "E3A" /product = "E3 ORF1" polyA_signal 28594 . . . 28599 /gene = "L4" CDS 29103 . . . 29303 /gene = "E3A" /product = "E3 ORF2" CDS 29300 . . . 29797 /gene = "E3A" /product = "E3 ORF3" CDS 29826 . . . 30731 /gene = "E3A" /product = "E3 ORF4" CDS 30728 . . . 31579 /gene = "E3A" /product = "E3 ORF5" CDS 31283 . . . 31579 /gene = "E3A" /product = "E3 ORF6" polyA_signal 31578 . . . 31584 /gene = "E3A" CDS 31591 . . . 31863 /gene = "E3B" /product = "E3 ORF7" CDS 31866 . . . 32264 /gene = "E3B" /product = "E3 ORF8" CDS 32257 . . . 32643 /gene = "E3B" /product = "E3 ORF9" polyA_signal 32659 . . . 32664 /gene = "E3B" gene complement(<32678 . . . 32838) /gene = "U" CDS complement(<32678 . . . 32838) /gene = "U" /note = "exon encoding C terminus unidentified; genus-common" /product = "protein U" CDS 32849 . . . 34585 /gene = "L5" /product = "L5_fiber" polyA_signal 34581 . . . 34586 /gene = "L5" gene complement(34611 . . . 37520) /gene = "E4" prim_transcript complement(34611 . . . 37490) /gene = "E4" polyA_signal complement(34625 . . . 34630) /gene = "E4" CDS complement(join)34794 . . . 35069, 35781 . . . 35954)) /gene = "E4" /product = "E4 0RF7" CDS complement(35070 . . . 35954) /gene = "E4" /product = "E4 ORF6" CDS complement(35875 . . . 36219) /gene = "E4" /product = "E4 ORF4" CDS complement(36235 . . . 36582) /gene = "E4" /product = "E4 ORF3" CDS complement(36579 . . . 36971) /gene = "E4" /product = "E4 ORF2" CDS complement(37029 . . . 37415) /gene = "E4" /product = "E4 ORF1" TATA_signal complement(37515 . . . 37520) /gene = "E4" repeat_region 37740 . . . 37830 /standard_name = "ITR" /rpt_type = inverted

[0180] In one embodiment, fragments of the sequences of SEQ ID NO: 7, 8, 9, 10 and their complementary strands, cDNA and RNA complementary thereto are provided. Suitably, fragments are at least 15 nucleotides in length, more suitably 30 nucleotides in length, more suitably 60 nucleotides in length, more suitably 120 nucleotides in length, more suitably 240, more suitably 480 nucleotides in length and encompass functional fragments, i.e., fragments which are of biological interest. For example, a functional fragment can express a desired adenoviral product or may be useful in production of recombinant viral vectors. Such fragments include the gene sequences listed above.

[0181] Gene products of the ChAd155 adenovirus, such as proteins, enzymes, and fragments thereof, which are encoded by the adenoviral nucleic acids described herein are provided. Such proteins include those encoded by the open reading frames identified above and the proteins encoded by the polynucleotides provided in the Sequence Listing.

[0182] Further ChAd155 Polynucleotides and Polypeptides

[0183] In some embodiments the polynucleotide of the invention comprises a polynucleotide encoding a fiber polypeptide; a penton polypeptide; a hexon polypeptide and penton polypeptide; a hexon polypeptide and fiber polypeptide; penton polypeptide and fiber polypeptide; or hexon polypeptide, penton polypeptide and fiber polypeptide of the invention; and may further comprise additional adenoviral polynucleotides, suitably ChAd155 polynucleotides. Thus, suitably the polynucleotide according to the invention comprises one or more of the following, the sequence coordinates relative to SEQ ID NO:10 provided in the previous annotation:

[0184] (a) an adenoviral 5'-inverted terminal repeat (ITR);

[0185] (b) an adenoviral E1A region, or a fragment thereof selected from among the E1A_280R and E1A_243R regions;

[0186] (c) an adenoviral E1B or IX region, or a fragment thereof selected from among the group consisting of the E1B_19K, E1B_55K and IX regions;

[0187] (d) an adenoviral E2B region; or a fragment thereof selected from among the group consisting of the E2B_pTP, E2B_polymerase and E2B_IVa2 regions;

[0188] (e) an adenoviral L1 region, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L1_13.6K, L1_52K and L1_pIIIa protein;

[0189] (f) an adenoviral L2 region or a L2 region comprising a polynucleotide encoding the penton protein of the invention, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L2_penton protein, the L2_pVII protein, the L2_V protein and the L2_pX protein;

[0190] (g) an adenoviral L3 region or a L3 region comprising a polynucleotide encoding the hexon protein of the invention, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L3_pVI protein, the L3_hexon protein and the L3_protease protein;

[0191] (h) an adenoviral E2A region;

[0192] (i) an adenoviral L4 region, or a fragment thereof said fragment encoding an adenoviral protein selected from the group consisting of the L4_100k protein, the L4_33K protein, the L4_22K protein and protein L4_VIII;

[0193] (j) an adenoviral E3 region, or a fragment thereof selected from the group consisting of E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, and E3 ORF9;

[0194] (k) an adenoviral L5 region or a L5 region comprising a polynucleotide encoding the L5_fiber fiber polypeptide of the invention

[0195] (l) an adenoviral (such as Ad5) E4 region, or a fragment thereof selected from the group consisting of E4 ORF7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2, and E4 ORF1; in particular ORF6 of said E4 region;

[0196] (m) an adenoviral 3'-ITR; and/or

[0197] (n) an adenoviral VAI or VAII RNA region, preferably an adenoviral VAI or VAII RNA region from an adenovirus other than ChAd155, more preferably from Ad5.

[0198] Definitions

[0199] Suitably the polynucleotides or polypeptides of the invention are isolated. An "isolated" polynucleotide is one that is removed from its original environment. For example, a naturally-occurring polynucleotide is isolated if it is separated from some or all of the coexisting materials in the natural system. A polynucleotide is considered to be isolated if, for example, it is cloned into a vector that is not a part of its natural environment or if it is comprised within cDNA.

[0200] Suitably the polynucleotides of the invention are recombinant. Recombinant means that the polynucleotide is the product of at least one of cloning, restriction or ligation steps, or other procedures that result in a polynucleotide that is distinct from a polynucleotide found in nature. A recombinant adenovirus is an adenovirus comprising a recombinant polynucleotide. A recombinant vector is a vector comprising a recombinant polynucleotide. `A recombinant virus` includes progeny of the original recombinant virus. `A recombinant vector` includes replicates of the original recombinant vector. `A recombinant polynucleotide` includes replicates of the original recombinant polynucleotide.

[0201] Suitably, the polypeptide sequence of the present invention contains at least one alteration with respect to a native sequence. Suitably, the polynucleotide sequences of the present invention contain at least one alteration with respect to a native sequence. For example, a polynucleotide introduced by genetic engineering techniques into a plasmid or vector derived from a different species (and often a different genus, subfamily or family) is a heterologous polynucleotide. A promoter removed from its native coding sequence and operatively linked to a coding sequence with which it is not naturally found linked is a heterologous promoter. A specific recombination site that has been cloned into a genome of a virus or viral vector, wherein the genome of the virus does not naturally contain it, is a heterologous recombination site. A heterologous nucleic acid sequence also includes a sequence naturally found in an adenoviral genome, but located at a non-native position within the adenoviral vector.

[0202] Typically, "heterologous" means derived from a genotypically distinct entity from that of the rest of the entity to which it is being compared. A heterologous nucleic acid sequence refers to any nucleic acid sequence that is not isolated from, derived from, or based upon a naturally occurring nucleic acid sequence of the adenoviral vector. "Naturally occurring" means a sequence found in nature and not synthetically prepared or modified. A sequence is "derived" from a source when it is isolated from a source but modified (e.g., by deletion, substitution (mutation), insertion, or other modification), suitably so as not to disrupt the normal function of the source gene.

[0203] A "functional derivative" of a polypeptide suitably refers to a modified version of a polypeptide, e.g. wherein one or more amino acids of the polypeptide may be deleted, inserted, modified and/or substituted. A derivative of an unmodified adenoviral capsid protein is considered functional if, for example:

[0204] (a) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a lower seroprevalence compared to an adenovirus comprising the unmodified capsid protein and/or

[0205] (b) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher host cell infectivity compared to an adenovirus comprising the unmodified capsid protein and/or

[0206] (c) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher immunogenicity compared to an adenovirus comprising the unmodified capsid protein and or

[0207] (d) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher level of transgene productivity compared to an adenovirus comprising the unmodified capsid protein.

[0208] Properties (a)-(d) above may suitably be measured using the methods described in the Examples section below.

[0209] Suitably, the polypeptide, vector or recombinant adenovirus has a low seroprevalence in a human population. "Low seroprevalence" may mean having a reduced pre-existing neutralizing antibody level as compared to human adenovirus 5 (Ad5). Similarly or alternatively, "low seroprevalence" may mean less than about 20% seroprevalence, less than about 15% seroprevalence, less than about 10% seroprevalence, less than about 5% seroprevalence, less than about 4% seroprevalence, less than about 3% seroprevalence, less than about 2% seroprevalence, less than about 1% seroprevalence or no detectable seroprevalence. Seroprevalence can be measured as the percentage of individuals having a clinically relevant neutralizing titre (defined as a 50% neutralisation titer >200) using methods as described in Aste-Amezaga et al., Hum. Gene Ther. (2004) 15(3):293-304.

[0210] The terms polypeptide, peptide and protein are used interchangeably herein.

[0211] The term "simian" is typically meant to encompass nonhuman primates, for example Old World monkeys, New World monkeys, apes and gibbons. In particular, simian may refer to nonhuman apes such as chimpanzees (Pan troglodyte), bonobos (Pan paniscus) and gorillas (genus Gorilla). Non-ape simians may include rhesus macaques (Macaca mulatta)

[0212] Sequence Comparison

[0213] For the purposes of comparing two closely-related polynucleotide or polypeptide sequences, the "% identity" between a first sequence and a second sequence may be calculated using an alignment program, such as BLAST.RTM. (available at blast.ncbi.nlm.nih.gov, last accessed 9 Mar. 2015) using standard settings. The % identity is the number of identical residues divided by the number of residues in the reference sequence, multiplied by 100. The identity figures referred to above and in the claims are percentages calculated by this methodology. An alternative definition of % identity is the number of identical residues divided by the number of aligned residues, multiplied by 100. Alternative methods include using a gapped method in which gaps in the alignment, for example deletions in one sequence relative to the other sequence, are accounted for in a gap score or a gap cost in the scoring parameter. For more information, see the BLAST.RTM. fact sheet available at ftp.ncbi.nlm.nih.gov/pub/factsheets/HowTo_BLASTGuide.pdf, last accessed on 9 Mar. 2015.

[0214] Sequences that preserve the functionality of the polynucleotide or a polypeptide encoded thereby are likely to be more closely identical. Polypeptide or polynucleotide sequences are said to be the same as or identical to other polypeptide or polynucleotide sequences, if they share 100% sequence identity over their entire length.

[0215] A "difference" between sequences refers to an insertion, deletion or substitution of a single amino acid residue in a position of the second sequence, compared to the first sequence. Two polypeptide sequences can contain one, two or more such amino acid differences. Insertions, deletions or substitutions in a second sequence which is otherwise identical (100% sequence identity) to a first sequence result in reduced percent sequence identity. For example, if the identical sequences are 9 amino acid residues long, one substitution in the second sequence results in a sequence identity of 88.9%. If the identical sequences are 17 amino acid residues long, two substitutions in the second sequence results in a sequence identity of 88.2%. If the identical sequences are 7 amino acid residues long, three substitutions in the second sequence results in a sequence identity of 57.1%. If first and second polypeptide sequences are 9 amino acid residues long and share 6 identical residues, the first and second polypeptide sequences share greater than 66% identity (the first and second polypeptide sequences share 66.7% identity). If first and second polypeptide sequences are 17 amino acid residues long and share 16 identical residues, the first and second polypeptide sequences share greater than 94% identity (the first and second polypeptide sequences share 94.1% identity). If first and second polypeptide sequences are 7 amino acid residues long and share 3 identical residues, the first and second polypeptide sequences share greater than 42% identity (the first and second polypeptide sequences share 42.9% identity).

[0216] Alternatively, for the purposes of comparing a first, reference polypeptide sequence to a second, comparison polypeptide sequence, the number of additions, substitutions and/or deletions made to the first sequence to produce the second sequence may be ascertained. An addition is the addition of one amino acid residue into the sequence of the first polypeptide (including addition at either terminus of the first polypeptide). A substitution is the substitution of one amino acid residue in the sequence of the first polypeptide with one different amino acid residue. A deletion is the deletion of one amino acid residue from the sequence of the first polypeptide (including deletion at either terminus of the first polypeptide).

[0217] For the purposes of comparing a first, reference polynucleotide sequence to a second, comparison polynucleotide sequence, the number of additions, substitutions and/or deletions made to the first sequence to produce the second sequence may be ascertained. An addition is the addition of one nucleotide residue into the sequence of the first polynucleotide (including addition at either terminus of the first polynucleotide). A substitution is the substitution of one nucleotide residue in the sequence of the first polynucleotide with one different nucleotide residue. A deletion is the deletion of one nucleotide residue from the sequence of the first polynucleotide (including deletion at either terminus of the first polynucleotide).

[0218] Suitably substitutions in the sequences of the present invention may be conservative substitutions. A conservative substitution comprises the substitution of an amino acid with another amino acid having a chemical property similar to the amino acid that is substituted (see, for example, Stryer et al, Biochemistry, 5.sup.th Edition 2002, pages 44-49). Preferably, the conservative substitution is a substitution selected from the group consisting of: (i) a substitution of a basic amino acid with another, different basic amino acid; (ii) a substitution of an acidic amino acid with another, different acidic amino acid; (iii) a substitution of an aromatic amino acid with another, different aromatic amino acid; (iv) a substitution of a non-polar, aliphatic amino acid with another, different non-polar, aliphatic amino acid; and (v) a substitution of a polar, uncharged amino acid with another, different polar, uncharged amino acid. A basic amino acid is preferably selected from the group consisting of arginine, histidine, and lysine. An acidic amino acid is preferably aspartate or glutamate. An aromatic amino acid is preferably selected from the group consisting of phenylalanine, tyrosine and tryptophane. A non-polar, aliphatic amino acid is preferably selected from the group consisting of glycine, alanine, valine, leucine, methionine and isoleucine. A polar, uncharged amino acid is preferably selected from the group consisting of serine, threonine, cysteine, proline, asparagine and glutamine. In contrast to a conservative amino acid substitution, a non-conservative amino acid substitution is the exchange of one amino acid with any amino acid that does not fall under the above-outlined conservative substitutions (i) through (v).

[0219] Vectors and Recombinant Adenovirus

[0220] The ChAd155 sequences of the invention are useful as therapeutic agents and in construction of a variety of vector systems, recombinant adenovirus and host cells. Suitably the term "vector" refers to a nucleic acid that has been substantially altered (e.g., a gene or functional region that has been deleted and/or inactivated) relative to a wild type sequence and/or incorporates a heterologous sequence, i.e.,nucleic acid obtained from a different source (also called an "insert"), and replicating and/or expressing the inserted polynucleotide sequence, when introduced into a cell (e.g., a host cell). For example, the insert may be all or part of the ChAd155 sequences described herein. In addition or alternatively, a ChAd155 vector may be a ChAd155 adenovirus comprising one or more deletions or inactivations of viral genes, such as E1 or other viral gene or functional region described herein. Such a ChAd155, which may or may not comprise a heterologous sequence, is often called a "backbone" and may be used as is or as a starting point for additional modifications to the vector.

[0221] A vector may be any suitable nucleic acid molecule including naked DNA, a plasmid, a virus, a cosmid, phage vector such as lambda vector, an artificial chromosome such as a BAC (bacterial artificial chromosome), or an episome. Alternatively, a vector may be a transcription and/or expression unit for cell-free in vitro transcription or expression, such as a T7-compatible system. The vectors may be used alone or in combination with other adenoviral sequences or fragments, or in combination with elements from non-adenoviral sequences. The ChAd155 sequences are also useful in antisense delivery vectors, gene therapy vectors, or vaccine vectors. Thus, further provided are gene delivery vectors, and host cells which contain the ChAd155 sequences.

[0222] The term "replication-competent" adenovirus refers to an adenovirus which can replicate in a host cell in the absence of any recombinant helper proteins comprised in the cell. Suitably, a "replication-competent" adenovirus comprises the following intact or functional essential early genes: E1A, E1B, E2A, E2B, E3 and E4. Wild type adenoviruses isolated from a particular animal will be replication competent in that animal.

[0223] The term "replication-incompetent" or "replication-defective" adenovirus refers to an adenovirus which is incapable of replication because it has been engineered to comprise at least a functional deletion (or "loss-of-function" mutation), i.e. a deletion or mutation which impairs the function of a gene without removing it entirely, e.g. introduction of artificial stop codons, deletion or mutation of active sites or interaction domains, mutation or deletion of a regulatory sequence of a gene etc, or a complete removal of a gene encoding a gene product that is essential for viral replication, such as one or more of the adenoviral genes selected from E1A, E1B, E2A, E2B, E3 and E4 (such as E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, E3 ORF9, E4 ORF7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2 and/or E4 ORF1). Particularly suitably E1 and optionally E3 and/or E4 are deleted. If deleted, the aforementioned deleted gene region will suitably not be considered in the alignment when determining % identity with respect to another sequence.

[0224] The present invention provides vectors such as recombinant adenovirus that deliver a protein, suitably a heterologous protein, to cells, either for therapeutic or vaccine purposes. A vector may include any genetic element including naked DNA, a phage, transposon, cosmid, episome, plasmid, or a virus. Such vectors contain DNA of ChAd155 as disclosed herein and a minigene. By "minigene" (or "expression cassette") is meant the combination of a selected heterologous gene (transgene) and the other regulatory elements necessary to drive translation, transcription and/or expression of the gene product in a host cell.

[0225] Typically, a ChAd155-derived adenoviral vector is designed such that the minigene is located in a nucleic acid molecule which contains other adenoviral sequences in the region native to a selected adenoviral gene. The minigene may be inserted into an existing gene region to disrupt the function of that region, if desired. Alternatively, the minigene may be inserted into the site of a partially or fully deleted adenoviral gene. For example, the minigene may be located in the site of a mutation, insertion or deletion which renders non-functional at least one gene of a genomic region selected from the group consisting of E1A, E1B, E2A, E2B, E3 and E4. The term "renders non-functional" means that a sufficient amount of the gene region is removed or otherwise disrupted, so that the gene region is no longer capable of producing functional products of gene expression. If desired, the entire gene region may be removed (and suitably replaced with the minigene).

[0226] For example, for a production vector useful for generation of a recombinant virus, the vector may contain the minigene and either the 5' end of the adenoviral genome or the 3' end of the adenoviral genome, or both the 5' and 3' ends of the adenoviral genome. The 5' end of the adenoviral genome contains the 5' cis-elements necessary for packaging and replication; i.e., the 5' ITR sequences (which function as origins of replication) and the native 5' packaging enhancer domains (that contain sequences necessary for packaging linear Ad genomes and enhancer elements for the E1 promoter). The 3' end of the adenoviral genome includes the 3' cis-elements (including the ITRs) necessary for packaging and encapsidation. Suitably, a recombinant adenovirus contains both 5' and 3' adenoviral cis-elements and the minigene (suitably containing a transgene) is located between the 5' and 3' adenoviral sequences. A ChAd155-based adenoviral vector may also contain additional adenoviral sequences.

[0227] Suitably, ChAd155-based vectors contain one or more adenoviral elements derived from the adenoviral ChAd155 genome of the invention. In one embodiment, the vectors contain adenoviral ITRs from ChAd155 and additional adenoviral sequences from the same adenoviral serotype. In another embodiment, the vectors contain adenoviral sequences that are derived from a different adenoviral serotype than that which provides the ITRs.

[0228] As defined herein, a pseudotyped adenovirus refers to an adenovirus in which the capsid proteins of the adenovirus are from a different adenovirus than the adenovirus which provides the ITRs.

[0229] Further, chimeric or hybrid adenoviruses may be constructed using the adenoviruses described herein using techniques known to those of skill in the art (e.g., U.S. Pat. No. 7,291,498).

[0230] ITRs and any other adenoviral sequences present in the vector of the present invention may be obtained from many sources. A variety of adenovirus strains are available from the American Type Culture Collection, Manassas, Va., or available by request from a variety of commercial and institutional sources. Further, the sequences of many such strains are available from a variety of databases including, e.g., PubMed and GenBank. Homologous adenovirus vectors prepared from other chimp or from human adenoviruses are described in the published literature (for example, U.S. Pat. No. 5,240,846). The DNA sequences of a number of adenovirus types are available from GenBank, including type Ad5 (GenBank Accession Number M73370). The adenovirus sequences may be obtained from any known adenovirus serotype, such as serotypes 2, 3, 4, 7, 12 and 40, and further including any of the presently identified human types. Similarly adenoviruses known to infect nonhuman animals (e.g., simians) may also be employed in the vector constructs of this invention (e.g., U.S. Pat. No. 6,083,716). The viral sequences, helper viruses (if needed), and recombinant viral particles, and other vector components and sequences employed in the construction of the vectors described herein may be obtained as described below.

[0231] Sequence, Vector and Adenovirus Production

[0232] The sequences of the invention may be produced by any suitable means, including recombinant production, chemical synthesis, or other synthetic means. Suitable production techniques are well known to those of skill in the art. Alternatively, peptides can also be synthesized by well known solid phase peptide synthesis methods.

[0233] The adenoviral plasmids (or other vectors) may be used to produce adenoviral vectors. In one embodiment, the adenoviral vectors are adenoviral particles which are replication-incompetent. In one embodiment, the adenoviral particles are rendered replication-incompetent by deletions in the E1A and/or E1B genes. Alternatively, the adenoviruses are rendered replication-incompetent by another means, optionally while retaining the E1A and/or E1B genes. Similarly, in some embodiments, reduction of an immune response to the vector may be accomplished by deletions in the E2B and/or DNA polymerase genes. The adenoviral vectors can also contain other mutations to the adenoviral genome, e.g., temperature-sensitive mutations or deletions in other genes. In other embodiments, it is desirable to retain an intact E1A and/or E1B region in the adenoviral vectors. Such an intact E1 region may be located in its native location in the adenoviral genome or placed in the site of a deletion in the native adenoviral genome (e.g., in the E3 region).

[0234] In the construction of adenovirus vectors for delivery of a gene to a mammalian (such as human) cell, a range of modified adenovirus nucleic acid sequences can be employed in the vectors. For example, all or a portion of the adenovirus delayed early gene E3 may be eliminated from the adenovirus sequence which forms a part of the recombinant virus. The function of E3 is believed to be irrelevant to the function and production of the recombinant virus particle. Adenovirus vectors may also be constructed having a deletion of at least the ORF6 region of the E4 gene, and more desirably because of the redundancy in the function of this region, the entire E4 region. Still another vector of the invention contains a deletion in the delayed early gene E2A. Deletions may also be made in any of the late genes L1 to L5 of the adenovirus genome. Similarly, deletions in the intermediate genes IX and IVa2 may be useful for some purposes. Other deletions may be made in the other structural or non-structural adenovirus genes. The above discussed deletions may be used individually, i.e., an adenovirus sequence for use as described herein may contain deletions in only a single region. Alternatively, deletions of entire genes or portions thereof effective to destroy their biological activity may be used in any combination. For example, in one exemplary vector, the adenovirus sequence may have deletions of the E1 genes and the E4 gene, or of the E1, E2A and E3 genes, or of the E1 and E3 genes, or of E1, E2A and E4 genes, with or without deletion of E3, and so on. Any one or more of the E genes may suitably be replaced with an E gene (or one or more E gene open reading frames) sourced from a different strain of adenovirus. Particularly suitably the ChAd155 E1 and E3 genes are deleted and the ChAd155E4 gene is replaced with E4Ad5orf6. As discussed above, such deletions and/or substitutions may be used in combination with other mutations, such as temperature-sensitive mutations, to achieve a desired result.

[0235] An adenoviral vector lacking one or more essential adenoviral sequences (e.g., E1A, E1B, E2A, E2B, E4 ORF6, L1, L2, L3, L4 and L5) may be cultured in the presence of the missing adenoviral gene products which are required for viral infectivity and propagation of an adenoviral particle. These helper functions may be provided by culturing the adenoviral vector in the presence of one or more helper constructs (e.g., a plasmid or virus) or a packaging host cell.

[0236] Complementation of Replication-Incompetent Vectors

[0237] To generate recombinant adenoviruses deleted in any of the genes described above, the function of the deleted gene region, if essential to the replication and infectivity of the virus, must be supplied to the recombinant virus by a helper virus or cell line, i.e., a complementation or packaging cell line.

[0238] Helper Viruses

[0239] Depending upon the adenovirus gene content of the viral vectors employed to carry the minigene, a helper adenovirus or non-replicating virus fragment may be used to provide sufficient adenovirus gene sequences necessary to produce an infective recombinant viral particle containing the minigene. Useful helper viruses contain selected adenovirus gene sequences not present in the adenovirus vector construct and/or not expressed by the packaging cell line in which the vector is transfected. In one embodiment, the helper virus is replication-defective and contains adenovirus genes in addition, suitably, to one or more of the sequences described herein. Such a helper virus is suitably used in combination with an E1 expressing (and optionally additionally E3 expressing) cell line.

[0240] A helper virus may optionally contain a reporter gene. A number of such reporter genes are known to the art as well as described herein. The presence of a reporter gene on the helper virus which is different from the transgene on the adenovirus vector allows both the adenoviral vector and the helper virus to be independently monitored. This reporter is used to enable separation between the resulting recombinant virus and the helper virus upon purification.

[0241] Complementation Cell Lines

[0242] In many circumstances, a cell line expressing the one or more missing genes which are essential to the replication and infectivity of the virus, such as human E1, can be used to transcomplement a chimp adenoviral vector. This is particularly advantageous because, due to the diversity between the chimp adenovirus sequences of the invention and the human adenovirus sequences found in currently available packaging cells, the use of the current human E1-containing cells prevents the generation of replication-competent adenoviruses during the replication and production process.

[0243] Alternatively, if desired, one may utilize the sequences provided herein to generate a packaging cell or cell line that expresses, at a minimum, the E1 gene from ChAd155 under the transcriptional control of a promoter for expression in a selected parent cell line. Inducible or constitutive promoters may be employed for this purpose. Examples of such promoters are described in detail elsewhere in this document. A parent cell is selected for the generation of a novel cell line expressing any desired ChAd155 gene. Without limitation, such a parent cell line may be HeLa [ATCC Accession No. CCL 2], A549 [ATCC Accession No. CCL 185], HEK 293, KB [CCL 17], Detroit [e.g., Detroit 510, CCL 72] and WI-38 [CCL 75] cells, among others. These cell lines are all available from the American Type Culture Collection, 10801 University Boulevard, Manassas, Va. 20110-2209.

[0244] Such E1-expressing cell lines are useful in the generation of recombinant adenovirus E1 deleted vectors. Additionally, or alternatively, cell lines that express one or more adenoviral gene products, e.g., E1A, E1B, E2A, E3 and/or E4, can be constructed using essentially the same procedures as used in the generation of recombinant viral vectors. Such cell lines can be utilised to transcomplement adenovirus vectors deleted in the essential genes that encode those products, or to provide helper functions necessary for packaging of a helper-dependent virus (e.g., adeno-associated virus). The preparation of a host cell involves techniques such as assembly of selected DNA sequences.

[0245] In another alternative, the essential adenoviral gene products are provided in trans by the adenoviral vector and/or helper virus. In such an instance, a suitable host cell can be selected from any biological organism, including prokaryotic (e.g., bacterial) cells, and eukaryotic cells, including, insect cells, yeast cells and mammalian cells.

[0246] Host cells may be selected from among any mammalian species, including, without limitation, cells such as A549, WEHI, 3T3, 1011/2, HEK 293 cells or Per.C6 (both of which express functional adenoviral El) [Fallaux, 1998], Saos, C2C12, L cells, HT1080, HepG2 and primary fibroblast, hepatocyte and myoblast cells derived from mammals including human, monkey, mouse, rat, rabbit, and hamster.

[0247] A particularly suitable complementation cell line is the Procell92 cell line. The Procell92 cell line is based on HEK 293 cells which express adenoviral E1 genes, transfected with the Tet repressor under control of the human phosphoglycerate kinase-1 (PGK) promoter, and the G418-resistance gene (Vitelli et al. PLOS One (2013) 8(e55435):1-9). Procell92.S is adapted for growth in suspension conditions and is useful for producing adenoviral vectors expressing toxic proteins (www.okairos.com/e/inners.php?m=00084, last accessed 13 Apr. 2015).

[0248] Assembly of a Viral Particle and Transfection of a Cell Line

[0249] Generally, when delivering the vector comprising the minigene by transfection, the vector is delivered in an amount from about 5 .mu.g to about 100 .mu.g DNA, and preferably about 10 to about 50 .mu.g DNA to about 1.times.10.sup.4 cells to about 1.times.10.sup.13 cells, and preferably about 10.sup.5 cells.

[0250] However, the relative amounts of vector DNA to host cells may be adjusted, taking into consideration such factors as the selected vector, the delivery method and the host cells selected.

[0251] Introduction into the host cell of the vector may be achieved by any means known in the art, including transfection, and infection. One or more of the adenoviral genes may be stably integrated into the genome of the host cell, stably expressed as episomes, or expressed transiently. The gene products may all be expressed transiently, on an episome or stably integrated, or some of the gene products may be expressed stably while others are expressed transiently.

[0252] Introduction of vectors into the host cell may also be accomplished using techniques known to the skilled person. Suitably, standard transfection techniques are used, e.g., CaPC transfection or electroporation.

[0253] Assembly of the selected DNA sequences of the adenovirus (as well as the transgene and other vector elements) into various intermediate plasmids, and the use of the plasmids and vectors to produce a recombinant viral particle are all achieved using conventional techniques. Such techniques include conventional cloning techniques of cDNA, use of overlapping oligonucleotide sequences of the adenovirus genomes, polymerase chain reaction, and any suitable method which provides the desired nucleotide sequence. Standard transfection and co-transfection techniques are employed, e.g., CaPC precipitation techniques. Other conventional methods employed include homologous recombination of the viral genomes, plaquing of viruses in agar overlay, methods of measuring signal generation, and the like.

[0254] For example, following the construction and assembly of the desired minigene-containing viral vector, the vector is transfected in vitro in the presence of a helper virus into the packaging cell line. Homologous recombination occurs between the helper and the vector sequences, which permits the adenovirus-transgene sequences in the vector to be replicated and packaged into virion capsids, resulting in the recombinant viral vector particles. The resulting recombinant adenoviruses are useful in transferring a selected transgene to a selected cell. In in vivo experiments with the recombinant virus grown in the packaging cell lines, the E1-deleted recombinant adenoviral vectors of the invention demonstrate utility in transferring a transgene to a non-simian mammal, preferably a human, cell.

[0255] Transgenes

[0256] The transgene is a nucleic acid sequence, heterologous to the vector sequences flanking the transgene, which encodes a protein of interest. The nucleic acid coding sequence is operatively linked to regulatory components in a manner which permits transgene transcription, translation, and/or expression in a host cell.

[0257] The composition of the transgene sequence will depend upon the use to which the resulting vector will be put. For example, the transgene may be a therapeutic transgene or an immunogenic transgene. Alternatively, a transgene sequence may include a reporter sequence, which upon expression produces a detectable signal. Such reporter sequences include, without limitation, DNA sequences encoding .beta.-lactamase, .beta.-galactosidase (LacZ), alkaline phosphatase, thymidine kinase, green fluorescent protein (GFP), chloramphenicol acetyltransferase (CAT), luciferase, membrane bound proteins including, for example, CD2, CD4, CD8, the influenza hemagglutinin protein, and others well known in the art, to which high affinity antibodies directed thereto exist or can be produced by conventional means, and fusion proteins comprising a membrane bound protein appropriately fused to an antigen tag domain from, among others, hemagglutinin or Myc. These coding sequences, when associated with regulatory elements which drive their expression, provide signals detectable by conventional means, including enzymatic, radiographic, colorimetric, fluorescence or other spectrographic assays, fluorescent activating cell sorting assays and immunological assays, including enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA) and immunohistochemistry.

[0258] In one embodiment, the transgene is a non-marker sequence encoding a product which is useful in biology and medicine, such as a therapeutic transgene or an immunogenic transgene such as proteins, RNA, enzymes, or catalytic RNAs. Desirable RNA molecules include tRNA, dsRNA, ribosomal RNA, catalytic RNAs, and antisense RNAs. One example of a useful RNA sequence is a sequence which extinguishes expression of a targeted nucleic acid sequence in the treated animal.

[0259] The transgene may be used for treatment, e.g., of genetic deficiencies, as a cancer therapeutic or vaccine, for induction of an immune response, and/or for prophylactic vaccine purposes. As used herein, induction of an immune response refers to the ability of a protein to induce a T cell and/or a humoral immune response to the protein.

[0260] Accordingly, in one embodiment the present invention provides a recombinant vector according to the present invention comprising an expression cassette comprising an immunogenic transgene derived from a pathogen. In certain embodiments the pathogen is a respiratory virus. Thus, the present invention provides a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV). In one embodiment the recombinant ChAd155-derived adenoviral vector of the present invention comprises an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. In certain embodiments, a recombinant vector comprises a nucleic acid sequence (for example within an expression cassette) which encodes a sequence according to SEQ ID NO: 37. In one embodiment, the recombinant vector consists essentially of a polynucleotide having a sequence according to SEQ IS NO: 11.

[0261] Regulatory Elements

[0262] In addition to the transgene the vector also includes conventional control elements which are operably linked to the transgene in a manner that permits its transcription, translation and/or expression in a cell transfected with the plasmid vector or infected with the virus produced by the invention. As used herein, "operably linked" sequences include both expression control sequences that are contiguous with the gene of interest and expression control sequences that act in trans or at a distance to control the gene of interest.

[0263] Expression control sequences include appropriate transcription initiation, termination, promoter and enhancer sequences; efficient RNA processing signals such as splicing and polyadenylation (poly A) signals including rabbit beta-globin polyA; sequences that stabilize cytoplasmic mRNA; sequences that enhance translation efficiency (e.g., Kozak consensus sequence); sequences that enhance protein stability; and when desired, sequences that enhance secretion of the encoded product. Among other sequences, chimeric introns may be used.

[0264] In some embodiments, the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) (Zuffrey et al. (1999) J Virol; 73(4):2886-9) may be operably linked to the transgene. An exemplary WPRE is provided in SEQ ID NO: 26.

[0265] A "promoter" is a nucleotide sequence that permits binding of RNA polymerase and directs the transcription of a gene. Typically, a promoter is located in the 5' non-coding region of a gene, proximal to the transcriptional start site of the gene. Sequence elements within promoters that function in the initiation of transcription are often characterized by consensus nucleotide sequences. Examples of promoters include, but are not limited to, promoters from bacteria, yeast, plants, viruses, and mammals (including humans). A great number of expression control sequences, including promoters which are internal, native, constitutive, inducible and/or tissue-specific, are known in the art and may be utilized.

[0266] Examples of constitutive promoters include, without limitation, the TBG promoter, the retroviral Rous sarcoma virus LTR promoter (optionally with the enhancer), the cytomegalovirus (CMV) promoter (optionally with the CMV enhancer, see, e.g., Boshart et al, Cell, 41:521-530 (1985)), the CASI promoter, the SV40 promoter, the dihydrofolate reductase promoter, the .beta.-actin promoter, the phosphoglycerol kinase (PGK) promoter, and the EF1a promoter (Invitrogen).

[0267] In some embodiments, the promoter is a CASI promoter (see, for example, WO2012/115980). The CASI promoter is a synthetic promoter which contains a portion of the CMV enhancer, a portion of the chicken beta-actin promoter, and a portion of the UBC enhancer. In some embodiments, the CASI promoter can include a nucleic acid sequence having at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or more, sequence identity to SEQ ID NO: 12. In some embodiments, the promoter comprises or consists of a nucleic acid sequence of SEQ ID NO: 12.

[0268] Inducible promoters allow regulation of gene expression and can be regulated by exogenously supplied compounds, environmental factors such as temperature, or the presence of a specific physiological state, e.g., acute phase, a particular differentiation state of the cell, or in replicating cells only. Inducible promoters and inducible systems are available from a variety of commercial sources, including, without limitation, Invitrogen, Clontech and Ariad. Many other systems have been described and can be readily selected by one of skill in the art. For example, inducible promoters include the zinc-inducible sheep metallothionine (MT) promoter and the dexamethasone (Dex)-inducible mouse mammary tumor virus (MMTV) promoter. Other inducible systems include the T7 polymerase promoter system (WO 98/10088); the ecdysone insect promoter (No et al, Proc. Natl. Acad. Sci. USA, 93:3346-3351 (1996)), the tetracycline-repressible system (Gossen et al, Proc. Natl. Acad. Sci. USA, 89:5547-5551 (1992)), the tetracycline-inducible system (Gossen et al, Science, 378:1766-1769 (1995), see also Harvey et al, Curr. Opin. Chem. Biol, 2:512-518 (1998)). Other systems include the FK506 dimer, VP16 or p65 using castradiol, diphenol murislerone, the RU486-inducible system (Wang et al, Nat. Biotech., 15:239-243 (1997) and Wang et al, Gene Ther., 4:432-441 (1997)) and the rapamycin-inducible system (Magari et al, J. Clin. Invest., 100:2865-2872 (1997)). The effectiveness of some inducible promoters increases over time. In such cases one can enhance the effectiveness of such systems by inserting multiple repressors in tandem, e.g., TetR linked to a TetR by an IRES.

[0269] In another embodiment, the native promoter for the transgene will be used. The native promoter may be preferred when it is desired that expression of the transgene should mimic the native expression. The native promoter may be used when expression of the transgene must be regulated temporally or developmentally, or in a tissue-specific manner, or in response to specific transcriptional stimuli. In a further embodiment, other native expression control elements, such as enhancer elements, polyadenylation sites or Kozak consensus sequences may also be used to mimic the native expression.

[0270] The transgene may be operably linked to a tissue-specific promoter. For instance, if expression in skeletal muscle is desired, a promoter active in muscle should be used. These include the promoters from genes encoding skeletal .beta.-actin, myosin light chain 2A, dystrophin, muscle creatine kinase, as well as synthetic muscle promoters with activities higher than naturally occurring promoters (see Li et al, Nat. Biotech., 17:241-245 (1999)). Examples of promoters that are tissue-specific are known for liver (albumin, Miyatake et al, J. Virol, 71:5124-32 (1997); hepatitis B virus core promoter, Sandig et al, Gene Ther., 3:1002-9 (1996); alpha-fetoprotein (AFP), Arbuthnot et al., Hum. Gene Ther., 7: 1503-14 (1996)), bone osteocalcin (Stein et al, Mol. Biol. Rep., 24:185-96 (1997)); bone sialoprotein (Chen et al., J. Bone Miner. Res., 11:654-64 (1996)), lymphocytes (CD2, Hansal et al, J. Immunol, 161:1063-8 (1998); immunoglobulin heavy chain; T cell receptor chain), neuronal such as neuron-specific enolase (NSE) promoter (Andersen et al, Cell. Mol. Neurobiol, 13:503-15 (1993)), neurofilament light-chain gene (Piccioli et al, Proc. Natl. Acad. Sci. USA, 88:5611-5 (1991)), and the neuron-specific vgf gene (Piccioli et al, Neuron, 15:373-84 (1995)), among others.

[0271] Optionally, vectors carrying transgenes encoding therapeutically useful or immunogenic products may also include selectable markers or reporter genes which may include sequences encoding geneticin, hygromicin or purimycin resistance, among others. Such selectable reporters or marker genes (preferably located outside the viral genome to be packaged into a viral particle) can be used to signal the presence of the plasmids in bacterial cells, such as ampicillin resistance. Other components of the vector may include an origin of replication.

[0272] These vectors are generated using the techniques and sequences provided herein, in conjunction with techniques known to those of skill in the art. Such techniques include conventional cloning techniques of cDNA such as those described in texts, use of overlapping oligonucleotide sequences of the adenovirus genomes, polymerase chain reaction, and any suitable method which provides the desired nucleotide sequence.

[0273] Therapeutics and Prophylaxis

[0274] The recombinant ChAd155-based vectors are useful for gene transfer to a human or non-simian mammal in vitro, ex vivo, and in vivo.

[0275] The recombinant adenovirus vectors described herein can be used as expression vectors for the production of the products encoded by the heterologous transgenes in vitro. For example, the recombinant replication-incompetent adenovirus containing a transgene may be transfected into a complementation cell line as described above.

[0276] A ChAd155-derived recombinant adenoviral vector provides an efficient gene transfer vehicle that can deliver a selected transgene to a selected host cell in vivo or ex vivo even where the organism has neutralizing antibodies to one or more adenovirus serotypes. In one embodiment, the vector and the cells are mixed ex vivo; the infected cells are cultured using conventional methodologies; and the transduced cells are re-infused into the patient. These techniques are particularly well suited to gene delivery for therapeutic purposes and for immunisation, including inducing protective immunity.

[0277] Immunogenic Transgenes

[0278] The recombinant ChAd155 vectors may also be as administered in immunogenic compositions. An immunogenic composition as described herein is a composition comprising one or more recombinant ChAd155 vector capable of inducing an immune response, for example a humoral (e.g., antibody) and/or cell-mediated (e.g., a cytotoxic T cell) response, against a transgene product delivered by the vector following delivery to a mammal, suitably a human. A recombinant adenovirus may comprise (suitably in any of its gene deletions) a gene encoding a desired immunogen and may therefore be used in a vaccine. The recombinant adenoviruses can be used as prophylactic or therapeutic vaccines against any pathogen for which the antigen(s) crucial for induction of an immune response and able to limit the spread of the pathogen has been identified and for which the cDNA is available.

[0279] Accordingly, in one embodiment the present invention provides the use of a recombinant adenovirus according to the present invention in the treatment of disease cause by a pathogen. In one embodiment, such treatment is prophylaxis. In one embodiment, the present invention provides the use of a recombinant adenovirus in the generation of an immune response against a pathogen. In certain embodiments the pathogen is a respiratory virus. Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the treatment or prophylaxis of RSV infection. In one embodiment the recombinant ChAd155-derived adenoviral vector of the present invention comprises an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37.

[0280] In further embodiments, the present invention provides the use of a recombinant adenovirus according to the present invention in the manufacture of a medicament for the generation of an immune response against a pathogen. Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the manufacture of a medicament for the treatment or prophylaxis of RSV infection. More specifically, the transgene encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11.

[0281] In one embodiment the present invention provides a method of treatment or prevention of a disease cause by a pathogen, comprising the administration of an effective amount of a recombinant adenovirus according to the present invention, for example a ChAd155-derived adenovirus, comprising an expression cassette comprising an immunogenic transgene derived from the pathogen. In certain embodiments the pathogen is human respiratory syncytial virus (RSV). In one embodiment the present invention provides a method of generating or enhancing an immune response directed against human respiratory syncytial virus (RSV) comprising the administration of a recombinant adenovirus according to the present invention. Particularly, the method of generating or enhancing an immune response comprises the administration of an effective amount of a ChAd155-derived adenovirus comprising a transgene encoding an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11.

[0282] In one embodiment, the present invention provides an immunogenic composition comprising a recombinant adenovirus according to the present invention, for example a ChAd155-derived adenovirus, including an expression cassette comprising an immunogenic transgene derived from a pathogen, for example human respiratory syncytial virus (RSV), and a pharmaceutically acceptable excipient.

[0283] Such vaccine or other immunogenic compositions may be formulated in a suitable delivery vehicle. Generally, doses for the immunogenic compositions are in the range defined below under `Delivery Methods and Dosage`. The levels of immunity of the selected gene can be monitored to determine the need, if any, for boosters. Following an assessment of antibody titers in the serum, optional booster immunizations may be desired.

[0284] In one embodiment an immunogenic composition comprising a recombinant ChAd155-derived adenoviral vector of the present invention comprising an expression cassette containing a transgene encoding an RSV F antigen and RSV M and N antigens. More specifically, the transgene encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11. Optionally, a vaccine or immunogenic composition of the invention may be formulated to contain other components, including, e.g., adjuvants, stabilizers, pH adjusters, preservatives and the like. Examples of suitable adjuvants are provided below under `Adjuvants`. Such an adjuvant can be administered with a priming DNA vaccine encoding an antigen to enhance the antigen-specific immune response compared with the immune response generated upon priming with a DNA vaccine encoding the antigen only. Alternatively, such an adjuvant can be administered with a polypeptide antigen which is administered in an administration regimen involving the ChAd155 vectors of the invention (as described below under `Administration Regimens`.

[0285] The recombinant adenoviruses are administered in an immunogenic amount, that is, an amount of recombinant adenovirus that is effective in a route of administration to transfect the desired target cells and provide sufficient levels of expression of the selected gene to induce an immune response. Where protective immunity is provided, the recombinant adenoviruses are considered to be vaccine compositions useful in preventing infection and/or recurrent disease.

[0286] Immunogens expressed by the inventive vectors which are useful to immunize a human or non-human animal against other pathogens include, e.g., bacteria, fungi, parasitic microorganisms or multicellular parasites which infect human and non-human vertebrates, or from a cancer cell or tumor cell. For example, immunogens may be selected from a variety of viral families. Examples of viral families against which an immune response would be desirable include respiratory viruses such as respiratory syncytial virus (RSV) and other paramyxoviruses such as human metapneumovirus, hMPV and parainfluenza viruses (PIV).

[0287] Infection with RSV does not confer full protective immunity. Infection in infancy is followed by symptomatic RSV re-infections which continue throughout adulthood. These re-infections generally go undiagnosed because they usually present as common acute upper respiratory tract infections. In more vulnerable persons (e.g., immunocompromised adults or elderly), re-infections can however also lead to severe disease. Both arms of the immune system (humoral and cellular immunity) are involved in protection from severe disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0288] Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection. Curr Top Microbiol Immunol. 2013; 372: 347-58.

[0289] Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev Anti Infect Ther. 2005; 3(5): 719-26.

[0290] Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination. Future Virol. 2008; 3(5): 445-454.

[0291] Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969; 89(4): 449-63.

[0292] Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med. 2012; 4(115): p. 115ra2.

[0293] Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein `cleavage` mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal `skip`. J Gen Virol. 2001; 82(Pt 5): 1013-25.

[0294] Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917

[0295] Guvenel, 2014].

[0296] The humoral immune response is capable of neutralizing the virus and inhibiting viral replication, thereby playing a major role in protection against lower respiratory RSV infection and severe disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0297] Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection. Curr Top Microbiol Immunol. 2013; 372: 347-58.

[0298] Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev Anti Infect Ther. 2005; 3(5): 719-26.

[0299] Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination. Future Virol. 2008; 3(5): 445-454.

[0300] Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969; 89(4): 449-63.

[0301] Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med. 2012; 4(115): p. 115ra2.

[0302] Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein `cleavage` mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal `skip`. J Gen Virol. 2001; 82(Pt 5): 1013-25.

[0303] Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917

[0304] Guvenel A K, Chiu C and Openshaw P J. Current concepts and progress in RSV vaccine development. Expert Rev Vaccines. 2014; 13(3): 333-44.

[0305] Hertz, M I, Englund J A, Snover D, et al., Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature. Medicine (Baltimore). 1989; 68(5): 269-81.

[0306] Kim H W, Canchola J G, Brandt C D et al., Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969; 89(4): 422-34.

[0307] Magro M, Andreu D, Gomez-Puertas P, et al., Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein. J Virol. 2010; 84(16): 7970-82.

[0308] Piedra, 2003]. Passive immunization, in the form of Immunoglobulin G (IgG) RSV-neutralizing monoclonal antibodies (Synagis) given prophylactically, has been shown to prevent RSV disease to some extent in premature infants and newborns with bronchopulmonary dysplasia or underlying cardiopulmonary disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0309] Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection. Curr Top Microbiol Immunol. 2013; 372: 347-58.

[0310] Cardenas, 2005].

[0311] T cells are also involved in the control of RSV disease. Lethal RSV infections have been described in patients with low CD8 T cells counts, as in the case of severe combined immunodeficiency, bone marrow and lung transplant recipients [Hertz, 1989]. The histopathology of fatal cases of RSV infection of newborns shows that there is a relative paucity of CD8 T cells in the lung infiltrate [Welliver, 2007]. Moreover, the presence of CD8 T cells producing Interferon-gamma (IFN-.gamma.) has been associated with diminished Th2 responses and reduced eosinophilia in animal models of RSV [Castilow, 2008; Stevens, 2009].

[0312] The recombinant vectors described herein are expected to be highly efficacious at inducing cytolytic T cells and antibodies directed to the inserted heterologous antigenic protein expressed by the vector.

[0313] Suitable antigens of RSV which are useful as immunogens to immunize a human or non-human animal can be selected from: the fusion protein (F), the attachment protein (G), the matrix protein (M2) and the nucleoprotein (N). The term "F protein" or "fusion protein" or "F protein polypeptide" or "fusion protein polypeptide" refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Fusion protein polypeptide. Similarly, the term "G protein" or "G protein polypeptide" refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Attachment protein polypeptide. The term "M protein" or "matrix protein" or "M protein polypeptide" refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Matrix protein and may include either or both of the M2-1 (which may be written herein as M2.1) and M2-2 gene products. Likewise, the term "N protein" or "Nucleocapsid protein" or "N protein polypeptide" refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Nucleoprotein.

[0314] Two groups of human RSV strains have been described, the A and B groups, based mainly on differences in the antigenicity of the G glycoprotein. Numerous strains of RSV have been isolated to date, any of which are suitable in the context of the antigens of the immunogenic combinations disclosed herein. Exemplary strains indicated by GenBank and/or EMBL Accession number can be found in US published application number 2010/0203071 (WO2008114149), which is incorporated herein by reference for the purpose of disclosing the nucleic acid and polypeptide sequences of RSV F and G proteins suitable for use in present invention. In an embodiment, the RSV F protein can be an ectodomain of an RSV F Protein (F.DELTA.TM).

[0315] Exemplary M and N protein nucleic acids and protein sequences can be found, e.g., in US published application number 2014/0141042 (WO2012/089833), which are incorporated herein for purpose of disclosing the nucleic acid and polypeptide sequences of RSV M and N proteins suitable for use in present invention.

[0316] Suitably, for use with in present invention, a transgene nucleic acid encodes an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens.

[0317] Fusion (F) Protein Deleted of the Transmembrane and Cytoplasmic Regions (F0.DELTA.TM)

[0318] The RSV F protein is a major surface antigen and mediates viral fusion to target cells. The F protein is an antigen which is highly conserved among RSV subgroups and strains. The F protein is a target for neutralizing antibodies, including the prophylactic RSV-neutralizing monoclonal antibody Synagis. Deletion of the transmembrane region and cytoplasmic tail permits secretion of the F.DELTA.TM protein. Neutralizing antibodies including Synagis, that recognize this soluble form of the F protein, inhibit RSV infectivity in vitro [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0319] Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection. Curr Top Microbiol Immunol. 2013; 372: 347-58.

[0320] Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev Anti Infect Ther. 2005; 3(5): 719-26.

[0321] Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination. Future Virol. 2008; 3(5): 445-454.

[0322] Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969; 89(4): 449-63.

[0323] Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med. 2012; 4(115): p. 115ra2.

[0324] Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein `cleavage` mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal `skip`. J Gen Virol. 2001; 82(Pt 5): 1013-25.

[0325] Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917

[0326] Guvenel A K, Chiu C and Openshaw P J. Current concepts and progress in RSV vaccine development. Expert Rev Vaccines. 2014; 13(3): 333-44.

[0327] Hertz, M I, Englund J A, Snover D, et al., Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature. Medicine (Baltimore). 1989; 68(5): 269-81.

[0328] Kim H W, Canchola J G, Brandt C D et al., Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969; 89(4): 422-34.

[0329] Magro, 2010].

[0330] Nucleocapsid (N) Protein

[0331] The N protein is an internal (non-exposed) antigen, highly conserved between RSV strains and known to be a source of many T cell epitopes [Townsend, 1984]. The N protein is essential for the replication and transcription of the RSV genome. The primary function of the N protein is to encapsulate the virus genome for the purposes of RNA transcription, replication and packaging and protects it from ribonucleases.

[0332] Transcription Anti-Termination (M2-1) Protein

[0333] The M2-1 protein is a transcription anti-termination factor that is important for the efficient synthesis of full-length messenger RNAs (mRNAs) as well as for the synthesis of polycistronic readthrough mRNAs, which are characteristic of non-segmented negative-strand RNA viruses. M2-1 is an internal (non-exposed) antigen, which is highly conserved between RSV strains and known to be a source of many T cell epitopes [Townsend, 1984].

[0334] In one embodiment, the present invention provides a recombinant ChAd155 vector comprising a transgene encoding an RSV F.DELTA.TM antigen, and RSV M2-1 and N antigens wherein a self-cleavage site is included between the RSV F.DELTA.TM antigen and the RSV M2-1 and a flexible linker is included between the RSV M2-1 and N antigens. In one embodiment a suitable transgene nucleic acid encodes the polypeptide represented by SEQ ID NO:37

[0335] In one embodiment, the immunogen may be from a retrovirus, for example a lentivirus such as the Human Immunodeficiency Virus (HIV). In such an embodiment, immunogens may be derived from HIV-1 or HIV-2.

[0336] The HIV genome encodes a number of different proteins, each of which can be immunogenic in its entirety or as a fragment when expressed by vectors of the present invention. Envelope proteins include gp120, gp41 and Env precursor gp160, for example. Non-envelope proteins of HIV include for example internal structural proteins such as the products of the gag and pol genes and other non-structural proteins such as Rev, Nef, Vif and Tat. In an embodiment the vector of the invention encodes one or more polypeptides comprising HIV Gag.

[0337] The Gag gene is translated as a precursor polyprotein that is cleaved by protease to yield products that include the matrix protein (p17), the capsid (p24), the nucleocapsid (p9), p6 and two space peptides, p2 and p1, all of which are examples of fragments of Gag.

[0338] The Gag gene gives rise to the 55-kilodalton (kD) Gag precursor protein, also called p55, which is expressed from the unspliced viral mRNA. During translation, the N terminus of p55 is myristoylated, triggering its association with the cytoplasmic aspect of cell membranes. The membrane-associated Gag polyprotein recruits two copies of the viral genomic RNA along with other viral and cellular proteins that triggers the budding of the viral particle from the surface of an infected cell. After budding, p55 is cleaved by the virally encoded protease (a product of the pol gene) during the process of viral maturation into four smaller proteins designated MA (matrix [p17]), CA (capsid [p24]), NC (nucleocapsid [p9]), and p6, all of which are examples of fragments of Gag. In one embodiment, the vectors of the present invention comprise a Gag polypeptide of SEQ ID NO: 38.

[0339] Adjuvants

[0340] An "adjuvant" as used herein refers to a composition that enhances the immune response to an immunogen. Examples of such adjuvants include but are not limited to inorganic adjuvants (e.g. inorganic metal salts such as aluminium phosphate or aluminium hydroxide), organic adjuvants (e.g. saponins, such as QS21, or squalene), oil-based adjuvants (e.g. Freund's complete adjuvant and Freund's incomplete adjuvant), cytokines (e.g. IL-1.beta., IL-2, IL-7, IL-12, IL-18, GM-CFS, and INF-.gamma.) particulate adjuvants (e.g. immuno-stimulatory complexes (ISCOMS), liposomes, or biodegradable microspheres), virosomes, bacterial adjuvants (e.g. monophosphoryl lipid A, such as 3-de-O-acylated monophosphoryl lipid A (3D-MPL), or muramyl peptides), synthetic adjuvants (e.g. non-ionic block copolymers, muramyl peptide analogues, or synthetic lipid A), synthetic polynucleotides adjuvants (e.g polyarginine or polylysine) and immunostimulatory oligonucleotides containing unmethylated CpG dinucleotides ("CpG").

[0341] One suitable adjuvant is monophosphoryl lipid A (MPL), in particular 3-de-O-acylated monophosphoryl lipid A (3D-MPL). Chemically it is often supplied as a mixture of 3-de-O-acylated monophosphoryl lipid A with either 4, 5, or 6 acylated chains. It can be purified and prepared by the methods taught in GB 2122204B, which reference also discloses the preparation of diphosphoryl lipid A, and 3-O-deacylated variants thereof. Other purified and synthetic lipopolysaccharides have been described (U.S. Pat. No. 6,005,099 and EP 0 729 473 B1; Hilgers et al., 1986, Int. Arch. Allergy. Immunol., 79(4):392-6; Hilgers et al., 1987, Immunology, 60(1):141-6; and EP 0 549 074 B11).

[0342] Saponins are also suitable adjuvants (see Lacaille-Dubois, M and Wagner H, A review of the biological and pharmacological activities of saponins. Phytomedicine vol 2 pp 363-386 (1996)). For example, the saponin Quil A (derived from the bark of the South American tree Quillaja Saponaria Molina), and fractions thereof, are described in U.S. Pat. No. 5,057,540 and Kensil, Crit. Rev. Ther. Drug Carrier Syst., 1996, 12:1-55; and EP 0 362 279 B1. Purified fractions of Quil A are also known as immunostimulants, such as QS21 and QS17; methods of their production is disclosed in U.S. Pat. No. 5,057,540 and EP 0 362 279 B1. Also described in these references is QS7 (a non-haemolytic fraction of Quil-A). Use of QS21 is further described in Kensil et al. (1991, J. Immunology, 146: 431-437). Combinations of QS21 and polysorbate or cyclodextrin are also known (WO 99/10008). Particulate adjuvant systems comprising fractions of QuilA, such as QS21 and QS7 are described in WO 96/33739 and WO 96/11711.

[0343] Another adjuvant is an immunostimulatory oligonucleotide containing unmethylated CpG dinucleotides ("CpG") (Krieg, Nature 374:546 (1995)). CpG is an abbreviation for cytosine-guanosine dinucleotide motifs present in DNA. CpG is known as an adjuvant when administered by both systemic and mucosal routes (WO 96/02555, EP 468520, Davis et al, J. Immunol, 1998, 160:870-876; McCluskie and Davis, J. Immunol., 1998, 161:4463-6). CpG, when formulated into vaccines, may be administered in free solution together with free antigen (WO 96/02555) or covalently conjugated to an antigen (WO 98/16247), or formulated with a carrier such as aluminium hydroxide (Brazolot-Millan et al., Proc. Natl. Acad. Sci., USA, 1998, 95:15553-8).

[0344] Adjuvants such as those described above may be formulated together with carriers, such as liposomes, oil in water emulsions, and/or metallic salts (including aluminum salts such as aluminum hydroxide). For example, 3D-MPL may be formulated with aluminum hydroxide (EP 0 689 454) or oil in water emulsions (WO 95/17210); QS21 may be formulated with cholesterol containing liposomes (WO 96/33739), oil in water emulsions (WO 95/17210) or alum (WO 98/15287); CpG may be formulated with alum (Brazolot-Millan, supra) or with other cationic carriers.

[0345] Combinations of adjuvants may be utilized in the present invention, in particular a combination of a monophosphoryl lipid A and a saponin derivative (see, e.g., WO 94/00153; WO 95/17210; WO 96/33739; WO 98/56414; WO 99/12565; WO 99/11241), more particularly the combination of QS21 and 3D-MPL as disclosed in WO 94/00153, or a composition where the QS21 is quenched in cholesterol-containing liposomes (DQ) as disclosed in WO 96/33739. Alternatively, a combination of CpG plus a saponin such as QS21 is an adjuvant suitable for use in the present invention. A potent adjuvant formulation involving QS21, 3D-MPL & tocopherol in an oil in water emulsion is described in WO 95/17210 and is another formulation for use in the present invention. Saponin adjuvants may be formulated in a liposome and combined with an immunostimulatory oligonucleotide. Thus, suitable adjuvant systems include, for example, a combination of monophosphoryl lipid A, preferably 3D-MPL, together with an aluminium salt (e.g. as described in WO00/23105). A further exemplary adjuvant comprises comprises QS21 and/or MPL and/or CpG. QS21 may be quenched in cholesterol-containing liposomes as disclosed in WO 96/33739.

[0346] Other suitable adjuvants include alkyl Glucosaminide phosphates (AGPs) such as those disclosed in WO9850399 or U.S. Pat. No. 6,303,347 (processes for preparation of AGPs are also disclosed), or pharmaceutically acceptable salts of AGPs as disclosed in U.S. Pat. No. 6,764,840. Some AGPs are TLR4 agonists, and some are TLR4 antagonists. Both are thought to be useful as adjuvants.

[0347] It has been found (WO 2007/062656, which published as US 2011/0293704 and is incorporated by reference for the purpose of disclosing invariant chain sequences) that the fusion of the invariant chain to an antigen which is comprised by an expression system used for vaccination increases the immune response against said antigen, if it is administered with an adenovirus. Accordingly, in one embodiment of the invention, the immunogenic transgene may be co-expressed with invariant chain in a recombinant ChAd155 viral vector.

[0348] In another embodiment, the invention provides the use of the capsid of ChAd155 (optionally an intact or recombinant viral particle or an empty capsid is used) to induce an immunomodulatory effect response, or to enhance or adjuvant a cytotoxic T cell response to another active agent by delivering a ChAd155 capsid to a subject. The ChAd155 capsid can be delivered alone or in a combination regimen with an active agent to enhance the immune response thereto. Advantageously, the desired effect can be accomplished without infecting the host with an adenovirus.

[0349] Administration Regimens

[0350] Commonly, the ChAd155 recombinant adenoviral vectors will be utilized for delivery of therapeutic or immunogenic molecules (such as proteins). It will be readily understood for both applications, that the recombinant adenoviral vectors of the invention are particularly well suited for use in regimens involving repeat delivery of recombinant adenoviral vectors. Such regimens typically involve delivery of a series of viral vectors in which the viral capsids are alternated. The viral capsids may be changed for each subsequent administration, or after a pre-selected number of administrations of a particular serotype capsid (e.g. one, two, three, four or more). Thus, a regimen may involve delivery of a recombinant adenovirus with a first capsid, delivery with a recombinant adenovirus with a second capsid, and delivery with a recombinant adenovirus with a third capsid. A variety of other regimens which use the adenovirus capsids of the invention alone, in combination with one another, or in combination with other adenoviruses (which are preferably immunologically non-crossreactive) will be apparent to those of skill in the art. Optionally, such a regimen may involve administration of recombinant adenovirus with capsids of other non-human primate adenoviruses, human adenoviruses, or artificial sequences such as are described herein.

[0351] The adenoviral vectors of the invention are particularly well suited for therapeutic regimens in which multiple adenoviral-mediated deliveries of transgenes are desired, e.g., in regimens involving redelivery of the same transgene or in combination regimens involving delivery of other transgenes. Such regimens may involve administration of a ChAd155 adenoviral vector, followed by re-administration with a vector from the same serotype adenovirus. Particularly desirable regimens involve administration of a ChAd155 adenoviral vector, in which the source of the adenoviral capsid sequences of the vector delivered in the first administration differs from the source of adenoviral capsid sequences of the viral vector utilized in one or more of the subsequent administrations. For example, a therapeutic regimen involves administration of a ChAd155 vector and repeat administration with one or more adenoviral vectors of the same or different serotypes.

[0352] In another example, a therapeutic regimen involves administration of an adenoviral vector followed by repeat administration with a ChAd155 vector which has a capsid which differs from the source of the capsid in the first delivered adenoviral vector, and optionally further administration with another vector which is the same or, preferably, differs from the source of the adenoviral capsid of the vector in the prior administration steps. These regimens may deliver the same or different therapeutic or immunogenic molecules. These regimens are not limited to delivery of adenoviral vectors constructed using the ChAd155 sequences. Rather, these regimens can readily utilize other adenoviral sequences, including, without limitation, other adenoviral sequences including other non-human primate adenoviral sequences, or human adenoviral sequences, in combination with the ChAd155 vectors.

[0353] In a further example, a therapeutic regimen may involve either simultaneous (such as co-administration) or sequential (such as a prime-boost) delivery of (i) one or more ChAd155 adenoviral vectors and (ii) a further component such as non-adenoviral vectors, non-viral vectors, and/or a variety of other therapeutically useful compounds or molecules such as antigenic proteins optionally simultaneously administered with adjuvant. These regimens may deliver the same or different therapeutic or immunogenic molecules. Examples of co-administration include homo-lateral co-administration and contra-lateral co-administration (further described below under `Delivery Methods and Dosage`).

[0354] Suitable non-adenoviral vectors for use in simultaneous or particularly in sequential delivery (such as prime-boost) with one or more ChAd155 adenoviral vectors include one or more poxviral vectors. Suitably, the poxviral vector belongs to the subfamily chordopoxvirinae, more suitably to a genus in said subfamily selected from the group consisting of orthopox, parapox, yatapox, avipox (suitably canarypox (ALVAC) or fowlpox (FPV)) and molluscipox. Even more suitably, the poxviral vector belongs to the orthopox and is selected from the group consisting of vaccinia virus, NYVAC (derived from the Copenhagen strain of vaccinia), Modified Vaccinia Ankara (MVA), cowpoxvirus and monkeypox virus. Most suitably, the poxviral vector is MVA.

[0355] "Simultaneous" administration suitably refers to the same ongoing immune response. Preferably both components are administered at the same time (such as simultaneous administration of both DNA and protein), however, one component could be administered within a few minutes (for example, at the same medical appointment or doctor's visit), within a few hours. Such administration is also referred to as co-administration. In some embodiments, co-administration may refer to the administration of an adenoviral vector, an adjuvant and a protein component. In other embodiments, co-administration refers to the administration of an adenoviral vector and another viral vector, for example a second adenoviral vector or a poxvirus such as MVA. In other embodiments, co-administration refers to the administration of an adenoviral vector and a protein component, which is optionally adjuvanted.

[0356] In another embodiment, a therapeutic regimen involves the administration of an immunogenic composition to a pregnant mother and subsequent administration of a further immunogenic composition to the infant after birth, for example 1, 2, 3, 4, 5, 6, 7 or 8 months after birth. Antibodies generated as a result of the maternal immunisation can cross the placenta to provide passive immunisation of the gestational infant. In one embodiment the maternal immunisation is by administration of a recombinant protein antigen and the infant immunisation is by administration of a recombinant adenoviral vector according to the present invention. In another embodiment the maternal immunisation is by administration of a recombinant adenoviral vector according to the present invention and the infant immunisation is by administration of a recombinant protein antigen. In another embodiment both the maternal and infant immunisation is by administration of a recombinant adenoviral vector according to the present invention.

[0357] Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector according to the present invention in the generation of an immune response against RSV in an infant, particularly an infant born to a mother immunised against RSV during pregnancy. Accordingly, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the manufacture of a medicament for the generation of an immune response in an infant. Desirably, particularly the infant born to a mother immunised against RSV during her pregnancy. More specifically, the transgene encodes an RSV F.DELTA.TM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11.

[0358] A prime-boost regimen may be used. Prime-boost refers to two separate immune responses in the same individual: (i) an initial priming of the immune system followed by (ii) a secondary or boosting of the immune system many weeks or months after the primary immune response has been established.

[0359] Such a regimen may involve the administration of a recombinant ChAd155 vector to prime the immune system to second, booster, administration with a traditional antigen, such as a protein (optionally co-administered with adjuvant), or a recombinant virus carrying the sequences encoding such an antigen (e.g., WO 00/11140). Alternatively, an immunization regimen may involve the administration of a recombinant ChAd155 vector to boost the immune response to a vector (either viral or DNA-based) encoding an antigen. In another alternative, an immunization regimen involves administration of a protein followed by booster with a recombinant ChAd155 vector encoding the antigen. In one example, the prime-boost regimen can provide a protective immune response to the virus, bacteria or other organism from which the antigen is derived. In another embodiment, the prime-boost regimen provides a therapeutic effect that can be measured using conventional assays for detection of the presence of the condition for which therapy is being administered.

[0360] Preferably, a boosting composition is administered about 2 to about 27 weeks after administering the priming composition to the subject. The administration of the boosting composition is accomplished using an effective amount of a boosting composition containing or capable of delivering the same antigen or a different antigen as administered by the priming vaccine. The boosting composition may be composed of a recombinant viral vector derived from the same viral source or from another source. Alternatively, the boosting composition can be a composition containing the same antigen as encoded in the priming vaccine, but in the form of a protein, which composition induces an immune response in the host. The primary requirements of the boosting composition are that the antigen of the composition is the same antigen, or a cross-reactive antigen, as that encoded by the priming composition.

[0361] Delivery Methods and Dosage

[0362] The vector may be prepared for administration by being suspended or dissolved in a pharmaceutically or physiologically acceptable carrier such as isotonic saline; isotonic salts solution or other formulations that will be apparent to those skilled in the art. The appropriate carrier will be evident to those skilled in the art and will depend in large part upon the route of administration. The compositions described herein may be administered to a mammal in a sustained release formulation using a biodegradable biocompatible polymer, or by on-site delivery using micelles, gels and liposomes.

[0363] In some embodiments, the recombinant adenovirus of the invention is administered to a subject by intramuscular injection, intravaginal injection, intravenous injection, intraperitoneal injection, subcutaneous injection, epicutaneous administration, intradermal administration, nasal administration or oral administration.

[0364] If the therapeutic regimen involves co-administration of one or more ChAd155 adenoviral vectors and a further component, each formulated in different compositions, they are favourably administered co-locationally at or near the same site. For example, the components can be administered (e.g. via an administration route selected from intramuscular, transdermal, intradermal, sub-cutaneous) to the same side or extremity ("co-lateral" administration) or to opposite sides or extremities ("contra-lateral" administration).

[0365] Dosages of the viral vector will depend primarily on factors such as the condition being treated, the age, weight and health of the patient, and may thus vary among patients. For example, a therapeutically effective adult human or veterinary dosage of the viral vector generally contains 1.times.10.sup.5 to 1.times.10.sup.15 viral particles, such as from 1.times.10.sup.8 to 1.times.10.sup.12 (e.g., 1.times.10.sup.8, 2.5.times.10.sup.8, 5.times.10.sup.8, 1.times.10.sup.9, 1.5.times.10.sup.9, 2.5.times.10.sup.9, 5.times.10.sup.9, 1.times.10.sup.10, 1.5.times.10.sup.10, 2.5.times.10.sup.10, 5.times.10.sup.10, 1.times.10.sup.11 1.5.times.10.sup.11, 2.5.times.10.sup.11, 5.times.10.sup.11, 1.times.10.sup.12 particles). Alternatively, a viral vector can be administered at a dose that is typically from 1.times.10.sup.5 to 1.times.10.sup.10 plaque forming units (PFU), such as 1.times.10.sup.5 PFU, 2.5.times.10.sup.5 PFU, 5.times.10.sup.5 PFU, 1.times.10.sup.6 PFU, 2.5.times.10.sup.6 PFU, 5.times.10.sup.6 PFU, 1.times.10.sup.7 PFU, 2.5.times.10.sup.7 PFU, 5.times.10.sup.7 PFU, 1.times.10.sup.8 PFU, 2.5.times.10.sup.8 PFU, 5.times.10.sup.8 PFU, 1.times.10.sup.9 PFU, 2.5.times.10.sup.9 PFU, 5.times.10.sup.9 PFU, or 1.times.10.sup.10 PFU. Dosages will vary depending upon the size of the animal and the route of administration. For example, a suitable human or veterinary dosage (for about an 80 kg animal) for intramuscular injection is in the range of about 1.times.10.sup.9 to about 5.times.10.sup.12 particles per mL, for a single site. Optionally, multiple sites of administration may be used. In another example, a suitable human or veterinary dosage may be in the range of about 1.times.10.sup.11 to about 1.times.10.sup.15 particles for an oral formulation.

[0366] The viral vector can be quantified by Quantitative PCR Analysis (Q-PCR), for example with primers and probe designed on CMV promoter region using as standard curve serial dilution of plasmid DNA containing the vector genome with expression cassette including HCMV promoter. The copy number in the test sample is determined by the parallel line analysis method. Alternative methods for vector particle quantification can be analytical HPLC or spectrophotometric method based on A.sub.260 nm.

[0367] An immunologically effective amount of a nucleic acid may suitably be between 1 ng and 100 mg. For example, a suitable amount can be from 1 .mu.g to 100 mg. An appropriate amount of the particular nucleic acid (e.g., vector) can readily be determined by those of skill in the art. Exemplary effective amounts of a nucleic acid component can be between 1 ng and 100 .mu.g, such as between 1 ng and 1 .mu.g (e.g., 100 ng-1 .mu.g), or between1 .mu.g and 100 .mu.g, such as 10 ng, 50 ng, 100 ng, 150 ng, 200 ng, 250 ng, 500 ng, 750 ng, or 1 .mu.g. Effective amounts of a nucleic acid can also include from 1 .mu.g to 500 .mu.g, such as between 1 .mu.g and 200 .mu.g, such as between 10 and 100 .mu.g, for example 1 .mu.g, 2 .mu.g, 5 .mu.g, 10 .mu.g, 20 .mu.g, 50 .mu.g, 75 .mu.g, 100 .mu.g, 150 .mu.g, or 200 .mu.g. Alternatively, an exemplary effective amount of a nucleic acid can be between 100 .mu.g and 1 mg, such as from 100 .mu.g to 500 .mu.g, for example, 100 .mu.g, 150 .mu.g, 200 .mu.g, 250 .mu.g, 300 .mu.g, 400 .mu.g, 500 .mu.g, 600 .mu.g, 700 .mu.g, 800 .mu.g, 900 .mu.g or 1 mg.

[0368] Generally a human dose will be in a volume of between 0.1 ml and 2 ml. Thus the composition described herein can be formulated in a volume of, for example 0.1, 0.15, 0.2, 0.5, 1.0, 1.5 or 2.0 ml human dose per individual or combined immunogenic components.

[0369] One of skill in the art may adjust these doses, depending on the route of administration and the therapeutic or vaccine application for which the recombinant vector is employed. The levels of expression of the transgene, or for an adjuvant, the level of circulating antibody, can be monitored to determine the frequency of dosage administration.

[0370] If one or more priming and/or boosting steps are used, this step may include a single dose that is administered hourly, daily, weekly or monthly, or yearly. As an example, mammals may receive one or two doses containing between about 10 .mu.g to about 50 .mu.g of plasmid in carrier.

[0371] The amount or site of delivery is desirably selected based upon the identity and condition of the mammal.

[0372] The therapeutic levels of, or level of immune response against, the protein encoded by the selected transgene can be monitored to determine the need, if any, for boosters. Following an assessment of CD8+ T cell response, or optionally, antibody titers, in the serum, optional booster immunizations may be desired. Optionally, the recombinant ChAd155 vectors may be delivered in a single administration or in various combination regimens, e.g., in combination with a regimen or course of treatment involving other active ingredients or in a prime-boost regimen.

[0373] The present invention will now be further described by means of the following non-limiting examples.

EXAMPLES

Example 1: Isolation of ChAd155

[0374] Wild type chimpanzee adenovirus type 155 (ChAd155) was isolated from a healthy young chimpanzee housed at the New Iberia Research Center facility (New Iberia Research Center; The University of Louisiana at Lafayette) using standard procedures as described in Colloca et al. (2012) and WO 2010086189, which is hereby incorporated by reference for the purpose of describing adenoviral isolation and characterization techniques

Example 2: ChAd155 Vector Construction

[0375] The ChAd155 viral genome was then cloned in a plasmid or in a BAC vector and subsequently modified (FIG. 2) to carry the following modifications in different regions of the ChAd155 viral genome:

[0376] a) deletion of the E1 region (from bp 449 to bp 3529) of the viral genome;

[0377] b) deletion of the E4 region (from bp 34731 to bp 37449) of the viral genome;

[0378] c) insertion of the E4orf6 derived from human AdS.

[0379] 2.1: Deletion of E1 Region: Construction of BAC/ChAd155 .DELTA.E1 TetO hCMV RpsL-Kana #1375

[0380] The ChAd155 viral genome was cloned into a BAC vector by homologous recombination in E. coli strain BJ5183 electroporation competent cells (Stratagene catalog no. 2000154) co-transformed with ChAd155 viral DNA and Subgroup C BAC Shuttle (#1365). As shown in the schematic of FIG. 3, the Subgroup C Shuttle is a BAC vector derived from pBeloBAC11 (GenBank U51113, NEB) and which is dedicated to the cloning of ChAd belonging to species C and therefore contains the pIX gene and DNA fragments derived from right and left ends (including right and left ITRs) of species C ChAd viruses.

[0381] The Species C BAC Shuttle also contains a RpsL-Kana cassette inserted between left end and the pIX gene. In addition, an Amp-LacZ-SacB selection cassette, flanked by ISceI restriction sites, is present between the pIX gene and right end of the viral genome. In particular, the BAC Shuttle comprised the following features: Left ITR: bp 27 to 139, hCMV(tetO) RpsL-Kana cassette: bp 493 to 3396, pIX gene: bp 3508 to 3972, ISceI restriction sites: bp 3990 and 7481, Amp-LacZ-SacB selection cassette: bp 4000 to 7471, Right ITR: bp 7805 to 7917.

[0382] BJ5183 cells were co-transformed by electroporation with ChAd155 purified viral DNA and Subgroup C BAC Shuttle vector digested with ISceI restriction enzyme and then purified from gel. Homologous recombination occurring between pIX gene and right ITR sequences (present at the ends of Species C BAC Shuttle linearized DNA) and homologous sequences present in ChAd155 viral DNA lead to the insertion of ChAd155 viral genomic DNA in the BAC shuttle vector. At the same time, the viral E1 region was deleted and substituted by the RpsL-Kana cassette, generating BAC/ChAd155 .DELTA.E1/TetO hCMV RpsL-Kana #1375.

[0383] 2.2: Plasmid Construction by Homologous Recombination in E. coli BJ5183

[0384] 2.2.1: Deletion of E4 Region--Construction of pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434)

[0385] To improve propagation of the vector, a deletion of the E4 region spanning from nucleotide 34731-37449 (ChAd155 wild type sequence) was introduced in the vector backbone by replacing the native E4 region with Ad5 E4orf6 coding sequence using a strategy involving several steps of cloning and homologous recombination in E. coli. The E4 coding region was completely deleted while the E4 native promoter and polyadenylation signal were conserved. To this end, a shuttle vector was constructed to allow the insertion of Ad5orf6 by replacing the ChAd155 native E4 region by homologous recombination in E. coli BJ5183 as detailed below.

[0386] Construction of pARS SpeciesC Ad5E4orf6-1

[0387] A DNA fragment containing Ad5orf6 was obtained by PCR using Ad5 DNA as template, with the oligonucleotides 5'-ATACGGACTAGTGGAGAAGTACTCGCCTACATG-3' (SEQ ID NO: 13) and 5'-ATACGGAAGATCTAAGACTTCAGGAAATATGACTAC-3' (SEQ ID NO: 14). The PCR fragment was digested with BgIII and SpeI and cloned into Species C RLD-EGFP shuttle digested with BgIII and SpeI, generating the plasmid pARS Species C Ad5orf6-1. Details regarding the shuttle can be found in Colloca et al, Sci. Transl. Med. (2012) 4:115ra.

[0388] Construction of pARS SpeciesC Ad5E4orf6-2

[0389] To delete the E4 region, a 177 bp DNA fragment spanning bp 34586 to bp 34730 of the ChAd155 wt sequence (SEQ ID NO: 10) was amplified by PCR using the plasmid BAC/ChAd155 .DELTA.E1_TetO hCMV RpsL-Kana (#1375) as a template with the following oligonucleotides: 5'-ATTCAGTGTACAGGCGCGCCAAAGCATGACGCTGTTGATTTGATTC-3' (SEQ ID NO: 15) and 5'-ACTAGGACTAGTTATAAGCTAGAATGGGGCTTTGC-3' (SEQ ID NO: 16). The PCR fragment was digested with BsrGI and SpeI and cloned into pARS SubGroupC Ad5orf6-1 digested with BsrGI and SpeI, generating the plasmid pARS SpeciesC Ad5orf6-2 (#1490). A schematic diagram of this shuttle plasmid is provided in FIG. 4. In particular, the shuttle plasmid comprised the following features: Left ITR: bp 1 to 113, Species C first 460bp: bp 1 to 460, ChAd155 wt (bp 34587 to bp 34724 of SEQ ID NO:10): bp 516 to 650, Ad5 orf6: bp 680 and 1561, Species C last 393 bp: bp 1567 to 1969, Right ITR: bp 1857 to 1969.

[0390] Construction of pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434)

[0391] The resulting plasmid pARS SubGroupC Ad5orf6-2 was then used to replace the E4 region within the ChAd155 backbone with Ad5orf6. To this end the plasmid BAC/ChAd155 .DELTA.E1_TetO hCMV RpsL-Kana (#1375) was digested with PacI/PmeI and co-transformed into BJ5183 cells with the digested plasmid pARS SubGroupC Ad5orf6-2 BsrGI/AscI, to obtain the pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) pre-adeno plasmid.

[0392] 2.2.2: Insertion of RSV Expression Cassette--Construction of pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RSV

[0393] The vaccine antigens are computational consensus sequences derived from the alignment of many different subgroup A RSV isolates retrieved from the National Centre for Biotechnology Information (NCBI) database. For each antigen the protein consensus sequence was derived using Multiple Sequence Comparison by Log-Expectation (MUSCLE) version 3.6 by alignment of all non-identical sequences and applying the majority rule. When blasted, the derived consensus sequence of the F protein was found to differ by only one amino acid from a natural annotated variant: embCAA26143.1. The consensus N protein also had only one amino acid different from the annotated variant ID:1494470, while the M2-1 protein was identical to the variant P04545. Finally, each antigenic sequence was codon-optimized for expression in eukaryotic cells, chemically synthesized and assembled. The construct, shown in FIG. 14 and SEQ ID NO: 37 contains the aphtovirus Foot and Mouth Disease Virus 2A region (18 amino acids) between the soluble F protein F.DELTA.TM and the other two RSV antigens, which mediates polyprotein processing by a translational effect known as ribosomal skip [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0394] Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection. Curr Top Microbiol Immunol. 2013; 372: 347-58.

[0395] Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev Anti Infect Ther. 2005; 3(5): 719-26.

[0396] Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination. Future Virol. 2008; 3(5): 445-454.

[0397] Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969; 89(4): 449-63.

[0398] Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med. 2012; 4(115): p. 115ra2.

[0399] Donnelly, 2001]. After transfection into mammalian cells, cleavage occurs and the soluble F protein is detected in the cell culture supernatant. The fusion protein N-M2-1 is instead expressed and detected in the intracellular fraction.

[0400] An RSV cassette was cloned into a linearised pre-adeno acceptor vector via homologous recombination in E. coli by exploiting the homology existing between HCMV promoter and BGH polyA sequences. The plasmid pvjTetOhCMV-bghpolyA_RSV was cleaved with SfiI and SpeI to excise the 4.65 Kb fragment containing the HCMV promoter with tetO, RSV and BGHpolyA sequence. The resulting RSV 4.65 Kb fragment was cloned by homologous recombination into the pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) acceptor vector carrying the RpsL-Kana selection cassette under control of HCMV and BGHpA. The acceptor pre-adeno plasmid was linearized with the restriction endonuclease SnaBI. The resulting construct was the pChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RSV vector (FIG. 5).

[0401] 2.3: BAC Vector Construction by Recombineering

[0402] 2.3.1: Deletion of E4 Region--Construction of BAC/ChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana #1390

[0403] A deletion of the E4 region spanning from nucleotide 34731-37449 of the ChAd155 wt sequence was introduced in the vector backbone by replacing this native E4 region with the Ad5 E4orf6 coding sequence using a strategy involving two different steps of recombineering in E. coli SW102 competent cells.

[0404] The first step resulted in insertion of a selection cassette including the suicide gene SacB, ampicillin-R gene and lacZ (Amp-LacZ-SacB selection cassette) in the E4 region of ChAd155, for the purpose of positive/negative selection of recombinants.

[0405] First Step--Substitution of ChAd155 Native E4 Region with Amp-LacZ-SacB Selection Cassette

[0406] The Amp-LacZ-SacB selection cassette was amplified by PCR using the oligonucleotides provided below containing E4 flanking sequences to allow homologous recombination:

TABLE-US-00002 1021-FW E4 Del Stepl (SEQ ID NO: 17) (5'- TTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTA GCTTATAACCCCTATTTGTTTATTTTTCT-3') and 1022-RW E4 Del Step1 (SEQ ID NO: 18) (5'- ATATATACTCTCTCGGCACTTGGCCTTTTACACTGCGAAGTGTTGGTGCT GGTGCTGCGTTGAGAGATCTTTATTTGTTAACTGTTAATTGTC-3').

[0407] The PCR product was used to transform E. coli SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1) tetO hCMV--RpsLKana #1375. The transformation of SW102 cells allowed the insertion of the selection cassette in the E4 region of ChAd155 via lambda (.lamda.) Red-mediated homologous recombination, thus obtaining BAC/ChAd155 (DE1) TetOhCMV--RpsL Kana #1379 (including Amp-LacZ-SacB cassette by substituting ChAd155 native E4 region).

[0408] Second Step--Substitution of Amp-IacZ-SacB Selection Cassette with Ad5E4orf6 Region

[0409] The resulting plasmid BAC/ChAd155 (DE1) TetOhCMV--RpsL Kana #1379 (with Amp-LacZ-SacB cassette in place of ChAd155 E4 region) was then manipulated to replace the Amp-lacZ-SacB selection cassette with Ad5orf6 within the ChAd155 backbone. To this end, a DNA fragment containing the Ad5orf6 region was obtained by PCR, using the oligonucleotides 1025-FW E4 Del Step2 (5'-TTAATAGACACAGTAGCTTAATA-3') (SEQ ID NO: 19) and 1026-RW E4 Del Step2 (5'-GGAAGGGAGTGTCTAGTGTT-3') (SEQ ID NO: 20). The resulting DNA fragment was introduced into E. coli SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1) TetOhCMV--RpsL Kana) #1379, resulting in a final plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV--RpsL Kana #1390 containing Ad5orf6 substituting the native ChAd155 E4 region.

[0410] 2.3.2: Insertion of RSV Expression Cassette: Construction of BAC/ChAd155 .DELTA.E1, E4_Ad5E4orf6/TetOhCMV RSV #1393

[0411] An RSV transgene was cloned into the BAC/ChAd155 .DELTA.E1, E4_Ad5E4orf6/TetOhCMV RpsL Kana #1390 vector by substituting the RpsL-Kana selection cassette. The construction strategy was based on two different steps of recombineering in E. coli SW102 competent cells.

[0412] First Step--Substitution of RpsL-Kana Cassette with Amp-LacZ-SacB Selection Cassette

[0413] The Amp-LacZ-SacB selection cassette was obtained from plasmid BAC/ChAd155 (DE1) TetO hCMV Amp-LacZ-SacB #1342 by PCR using the oligonucleotides 91-SubMonte FW (5'-CAATGGGCGTGGATAGCGGTTTGAC-3') (SEQ ID NO: 21) and 890-BghPolyA RW (5'-CAGCATGCCTGCTATTGTC-3') (SEQ ID NO: 22). The product was transformed into E. coli SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV--RpsL Kana #1390, resulting in BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV--Amp-LacZ-SacB #1386.

[0414] Second Step--Substitution of Amp-lacZ-SacB Selection Cassette with RSV Transgene

[0415] The RSV transgene was inserted in plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV--Amp-LacZ-SacB #1386 by replacing the Amp-lacZ-SacB selection cassette by homologous recombination. To this end, the plasmid pvjTetOhCMV-bghpolyA_RSV #1080 (containing an RSV expression cassette) was cleaved with SpeI and SfiI to excise the 4.4 Kb fragment including the HCMV promoter, RSV and BGHpolyA. The resulting RSV 4.4 Kb fragment was transformed into E. coli SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1, E4 Adr5E4orf6) TetOhCMV--Amp-LacZ-SacB #1386, resulting in the final plasmid BAC/ChAd155 .DELTA.E1, E4_Ad5E4orf6/TetO hCMV RSV #1393. The structure of the BAC carrying ChAd155/RSV (SEQ ID NO: 11) is illustrated in FIG. 6. In particular, ChAd155/RSV comprised the following features: Species C Left ITR: bp 1 to 113, hCMV(tetO) bp 467 to 1311, RSV gene: bp 1348 to 4785, bghpolyA: by 4815 to 5032, Ad5E4orf6: bp 36270 to 37151, Species C Right ITR: bp 37447 to 37559.

Example 3: Vector Production

[0416] The productivity of ChAd155 was evaluated in comparison to ChAd3 and PanAd3 in the Procell 92 cell line.

[0417] 3.1: Production of Vectors comprising an HIV Gag Transgene

[0418] Vectors expressing the HIV Gag protein were prepared as described above (ChAd155/GAG) or previously (ChAd3/GAG Colloca et al, Sci. Transl. Med. (2012) 4:115ra). ChAd3/GAG and ChAd155/GAG were rescued and amplified in Procell 92 until passages 3 (P3); P3 lysates were used to infect 2 T75 flasks of Procell 92 cultivated in monolayer with each vector. A multiplicity of infection (MOI) of 100 vp/cell was used for both infection experiments. The infected cells were harvested when full CPE was evident (72 hours post-infection) and pooled; the viruses were released from the infected cells by 3 cycles of freeze/thaw (-70.degree./37.degree. C.) then the lysate was clarified by centrifugation. The clarified lysates were quantified by Quantitative PCR Analysis with primers and probe complementary to the CMV promoter region. The oligonucleotide sequences are the following: CMVfor 5'-CATCTACGTATTAGTCATCGCTATTACCA-3' (SEQ ID NO: 23), CMVrev 5'-GACTTGGAAATCCCCGTGAGT-3' (SEQ ID NO: 24), CMVFAM-TAMRA probe 5'-ACATCAATGGGCGTGGATAGCGGTT-3' (SEQ ID NO: 25) (QPCRs were run on ABI Prism 7900 Sequence detector--Applied Biosystem). The resulting volumetric titers (vp/ml) measured on clarified lysates and the specific productivity expressed in virus particles per cell (vp/cell) are provided in Table 1 below and illustrated in FIG. 7.

TABLE-US-00003 TABLE 1 Vector productivity from P3 lysates. Total vp Vector vp/ml (20 ml conc.) vp/cell ChAd3/GAG 9.82E+09 1.96E+11 6.61E+03 ChAd155/GAG 1.11E+10 2.22E+11 7.46E+03

[0419] To confirm the higher productivity of the ChAd155 vector expressing HIV Gag transgene, a second experiment was performed by using purified viruses as inoculum. To this end, Procell 92 cells were seeded in a T25 Flask and infected with ChAd3/GAG and ChAd155/GAG when the confluence of the cells was about 80%, using a MOI=100 vp/cell of infection. The infected cells were harvested when full CPE was evident; the viruses were released from the infected cells by freeze/thaw and clarified by centrifugation. The clarified lysates were quantified by Quantitative PCR Analysis by using following primers and probe: CMVfor 5'-CATCTACGTATTAGTCATCGCTATTACCA-3' (SEQ ID NO: 23), CMV rev GACTTGGAAATCCCCGTGAGT (SEQ ID NO: 24), CMV FAM-TAMRA probe 5'-ACATCAATGGGCGTGGATAGCGGTT-3' (SEQ ID NO: 25) complementary to the CMV promoter region (samples were analysed on an ABI Prism 7900 Sequence detector--Applied Biosystems). The resulting volumetric titers (vp/ml) measured on clarified lysates and the specific productivity expressed in virus particles per cell (vp/cell) are provided in Table 2 below and illustrated in FIG. 8.

TABLE-US-00004 TABLE 2 Vector productivity from purified viruses. Total vp/T25 flask Vector vp/ml (5 ml of lysate) vp/cell ChAd3/GAG 1.00E+10 5.00E+10 1.67E+04 ChAd155/GAG 1.21E+10 6.05E+10 2.02E+04

[0420] 3.2: Production of Vectors comprising an RSV Transgene

[0421] A different set of experiments were performed to evaluate the productivity of RSV vaccine vectors in Procell 92.S cultivated in suspension. The experiment compared PanAd3/RSV (described in WO2012/089833) and Chad155/RSV in parallel by infecting Procell 92.S at a cell density of 5.times.10.sup.5 cells/ml. The infected cells were harvested 3 days post infection; the virus was released from the infected cells by 3 cycles of freeze/thaw and the lysate was clarified by centrifugation. The clarified lysates were then quantified by Quantitative PCR Analysis as reported above. The volumetric productivity and the cell specific productivity are provided in Table 3 below and illustrated in FIG. 9.

TABLE-US-00005 TABLE 3 Volumetric Cell specific productivity productivity Virus (Vp/ml) Total vp (vp/cell) PanAd3/RSV 5.82E+09 2.91E+11 1.16E+4 ChAd155/RSV 3.16E+10 1.58E+12 6.31E+04

Example 4: Transgene Expression Levels

[0422] 4.1: Expression Level of HIV Gag Transgene

[0423] Expression levels were compared in parallel experiments by infecting HeLa cells with ChAd3 and ChAd155 vectors comprising an HIV Gag transgene. HeLa cells were seeded in 24 well plates and infected in duplicate with ChAd3/GAG and ChAd155/GAG purified viruses using a MOI=250 vp/cell. The supernatants of HeLa infected cells were harvested 48 hours post-infection, and the production of secreted HIV GAG protein was quantified by using a commercial ELISA Kit (HIV-1 p24 ELISA Kit, PerkinElmer Life Science). The quantification was performed according to the manufacturer's instruction by using an HIV-1 p24 antigen standard curve. The results, expressed in pg/ml of GAG protein, are illustrated in FIG. 10.

[0424] 4.1: Expression Level of RSV F Transgene

[0425] Expression levels were compared in parallel experiments by infecting HeLa cells with the above-described PanAd3 and ChAd155 vectors comprising an RSV F transgene. To this end, HeLa cells were seeded in 6 well plates and infected in duplicate with PanAd3/RSV and ChAd155/RSV purified viruses using a MOI=500 vp/cell. The supernatants were harvested 48 hours post-infection, and the production of secreted RSV F protein was quantified by ELISA. Five different dilutions of the supernatants were transferred to microplate wells which are coated with a commercial mouse anti-RSV F monoclonal antibody. The captured antigen was revealed using a secondary anti-RSV F rabbit antiserum followed by Biotin-conjugated anti-rabbit IgG, then by adding Streptavidin-AP conjugate (BD Pharmingen cat. 554065). The quantification was performed by using an RSV F protein (Sino Biological cat. 11049-V08B) standard curve. The results obtained, expressed as ug/ml of RSV F protein, are provided in Table 4 below.

TABLE-US-00006 TABLE 4 Sample .mu.g/ml RSV F protein ChAd155/RSV 5.9 PanAd3/RSV 4

[0426] A western blot analysis was also performed to confirm the higher level of transgene expression provided by the ChAd155 RSV vector relative to the PanAd3 RSV vector. HeLa cells plated in 6 well plates were infected with PanAd3/RSV and ChAd155/RSV purified viruses using MOI=250 and 500 vp/cell. The supernatants of HeLa infected cells were harvested and the production of secreted RSV F protein were analysed by non-reducing SDS gel followed by Western Blot analysis. Equivalent quantities of supernatants were loaded on non-reducing SDS gel; after electrophoresis separation, the proteins were transferred to a nitrocellulose membrane to be probed with an anti-RSV F mouse monoclonal antibody (clone RSV-F-3 catalog no: ABIN308230 available at antibodies-online.com (last accessed 13 Apr. 2015). After the incubation with primary antibody, the membrane was washed and then incubated with anti-mouse HRP conjugate secondary antibody. Finally the assay was developed by electrochemiluminescence using standard techniques (ECL detection reagents Pierce catalog no W3252282). The Western Blot results are shown in FIG. 11. A band of about 170 kD indicated by the arrow was revealed by monoclonal antibody mAb 13 raised against the F protein, which corresponds to the expected weight of trimeric F protein. It can be seen that the ChAd155 RSV vector produced a darker band at both MOI=250 and 500 vp/cell.

Example 5: Evaluation of Immunological Potency by Mouse Immunization Experiments

[0427] 5.1: Immunogenicity of Vectors comprising the HIV Gag Transgene

[0428] The immunogenicity of the ChAd155/GAG vector was evaluated in parallel with the ChAd3/GAG vector in BALB/c mice (5 per group). The experiment was performed by injecting 10.sup.6 viral particles intramuscularly. T-cell response was measured 3 weeks after the immunization by ex vivo IFN-gamma enzyme-linked immunospot (ELISpot) using a GAG CD8+ T cell epitope mapped in BALB/c mice. The results are shown in FIG. 12, expressed as IFN-gamma Spot Forming Cells (SFC) per million of splenocytes. Each dot represents the response in a single mouse, and the line corresponds to the mean for each dose group. Injected dose in number of virus particles and frequency of positive mice to the CD8 immunodominant peptide are shown on the x axis.

[0429] 5.2 Immunogenicity of Vectors comprising the RSV Transgene

[0430] Preclinical studies to evaluate the immunogenicity of the vaccine candidate ChAd155-RSV were performed in inbred BALB/c mice (5.2.1). The vaccine efficacy was also evaluated in cotton rats after intranasal (IN) challenge with RSV through measurement of viral load in lower (lung) or upper (nasal tissue) respiratory tract (5.2.2). Finally, the vaccine was tested in young seronegative calves, which is a model that mimics natural RSV infection (5.2.3).

[0431] 5.2.1--Inbred Mice

[0432] ChAd155-RSV was tested in the BALB/c mouse strain to evaluate its immunological potency. Dose escalation in inbred mice is the standard assay that has enabled the ranking of chimpanzee adenoviral vectors immunological potency in mice with results that have been confirmed consistently across species (non-human primates and humans) [Colloca, 2012].

[0433] The immunological potency of the PanAd3/RSV and ChAd155/RSV vectors was evaluated in BALB/c mice. Both vectors were injected intramuscularly at doses of 3.times.10.sup.6, 10.sup.7, and 10.sup.8 vp. Three weeks after vaccination the splenocytes of immunized mice were isolated and analyzed by IFN-gamma-ELISpot using as antigens immunodominant peptide F and M epitopes mapped in BALB/c mice. The levels of immune-responses were reduced in line with decreasing dosage (as expected) but immune responses were clearly higher in the groups of mice immunized with ChAd155/RSV vector compared to the equivalent groups of mice immunized with PanAd3/RSV vaccine (FIG. 13). In FIG. 13, symbols show individual mouse data, expressed as IFN-gamma Spot Forming Cells (SFC)/million splenocytes, calculated as the sum of responses to the three immunodominant epitopes (F.sub.51-66 F.sub.85-93 and M2-1.sub.282-290) and corrected for background. Horizontal lines represent the mean number of IFN-gamma SFC/million splenocytes for each dose group. A T cell dose response was observed in ChAd155-RSV immunized mice with all mice responding even at the low 3.times.10.sup.6 vp dosage. PanAd3-RSV induced comparable responses at the highest dosage, while ChAd155-RSV induced higher responses at the two lower dosages (FIG. 13).

[0434] In a second study, a group of BALB/c mice received ChAd155-RSV and another group received PanAd3-RSV, IM at a single dose of 5.times.10.sup.8 vp. The mice (n=5/group) were subsequently bled every two weeks starting from Week 4 post-vaccination up to Week 10, to monitor induction and maintenance of anti F antibodies. Pooled sera from immunized mice were tested in Enzyme-Linked Immunosorbent Assay (ELISA) on coated RSV-F protein. FIG. 15 shows RSV F Immunoglobulin G (IgG) titers, measured by ELISA in pooled sera from immunized mice at different time points from vaccination. Pooled sera serial dilutions were plated in RSV-F protein coated ELISA wells, and the binding of specific IgG revealed using a goat anti-mouse IgG conjugated to Alkaline Phosphatase (AP) and p-Nitrophenyl Phosphate (pNPP) substrate. The reaction was allowed to proceed over time and read at 405 nanometres (nm) during fixed time points. Data are expressed as endpoint titers calculated as the dilution of serum giving an optical density (OD).sub.405 reading greater than three Standard Deviations (SDs) above the mean of pre-immune sera at a 1:100 dilution. Antibody responses to RSV F protein were induced by ChAd155-RSV and maintained over a period of 10 weeks after a single IM administration of 5.times.10.sup.8 vp, and antibody titers were 1.5-fold higher at plateau than those induced by PanAd3-RSV (FIG. 15).

[0435] 5.2.2--Cotton Rats

[0436] Methodology

[0437] Five groups of female, 6-8 weeks old cotton rats (8 rats/group) were immunized by the intramusculat (IM) route with 5.times.10.sup.8 or 5.times.10.sup.7 vp of ChAd155-RSV or PanAd3-RSV (see Table 5). A control group was left unvaccinated. Seven weeks after vaccination, the animals were challenged by intranasal (IN) inoculation with a 10.sup.5 pfu standard dose of RSV A (Long strain). Five days after challenge, the animals were sacrificed, the nasal tissue harvested for viral titration, and the lung en bloc collected and bisected for viral titration (left lobes) and histopathology (right lobes, Groups A, D, E only). RSV titers in nasal tissue or lung homogenates collected five days after RSV challenge were determined by a standard plaque assay on permissive cells (HEp-2 cells). FFPE lung sections were stained with Hematoxylin/Eosin. Four parameters of pulmonary inflammation were evaluated: peribronchiolitis (PB), perivasculitis (PV), interstitial pneumonia (IP), and alveolitis (A). Slides were scored blind on a 0-4 severity scale, and values were then converted to a 0-100% histopathology score. The animals were also bled at Day 0 and at the time of challenge, for RSV neutralizing antibody titration by standard plaque assay on permissive cells (Vero cells). Neutralizing antibody titers were determined as the reciprocal of the serum dilutions at which 60% of the virus was neutralized compared to virus control.

TABLE-US-00007 TABLE 5 Dosing scheme of cotton rats Group Vaccine Immunization dose A Control -- B PanAd3-RSV IM 5 .times. 10.sup.8 vp C PanAd3-RSV IM 5 .times. 10.sup.7 vp D ChAd155-RSV IM 5 .times. 10.sup.8 vp E ChAd155-RSV IM 5 .times. 10.sup.7 vp

[0438] Immunogenicity and Efficacy Results

[0439] FIG. 16 panels A and B show the RSV viral titers from nasal tissue and lung homogenates, respectively, by plaque assay. RSV titers in nasal tissue or lung homogenates collected five days after RSV challenge were determined by a standard plaque assay on permissive cells. Data are expressed as RSV plaque forming units per gram of tissue (pfu/g). intramuscular ChAd155-RSV at both dosages completely abolished viral replication in the lung, apart from one animal at the lowest dosage. Infection of the upper respiratory tract was also significantly reduced (between 1 and 2 logs lower RSV titers recovered from nasal tissue) in a dose-dependent manner compared to unvaccinated control animals.

[0440] It has been previously shown that in cotton rats a serum neutralizing antibody titer of 1:100 or greater confers protection from viral replication in the lung [Prince, 1985]. In this study both vectors administered IM at 5.times.10.sup.8 vp induced RSV neutralizing antibodies in the range of the protective threshold while titers decreased with a lower vaccine dosage (FIG. 16 panel C). Nevertheless, the vaccination prevented viral replication in the lung even when serum antibody levels were below 1:100, suggesting a role for other immune effector mechanisms. RSV neutralizing antibody titers are expressed as the serum dilution reducing plaques by 60% compared to control.

[0441] Safety Results

[0442] Lung histopathology was performed five days post-infection to assess whether vaccination with ChAd155-RSV induced vaccine-enhanced pathology. Four parameters of pulmonary inflammation were evaluated according to the presence of inflammatory cells in different areas of the lung structure: peribronchiolitis (PB, inflammatory cell infiltration around the bronchioles), perivasculitis (PV, inflammatory cell infiltration around the small blood vessels), interstitial pneumonia (IP, inflammatory cell infiltration and thickening of alveolar walls), and alveolitis (A, cells within the alveolar space). Formalin-fixed, paraffin-embedded lung sections were stained with Hematoxylin/Eosin. Slides were scored blind on a 0-4 severity scale, and values were then converted to a 0-100% histopathology score. The dashed line (set at 5%) represents the threshold for significant pathology. Histopathology data for PanAd3-RSV (depicted in grey) derive from a previous study. Among the four parameters, the presence of inflammatory infiltrate in the alveolar walls (interstitial pneumonia [IP]), and more importantly in the alveolar space, (alveolitis [A]), is considered predictive for enhanced disease and lung pathology [Prince, 2001]. The results of the lung histopathology analysis (FIG. 16 panel D) showed that IM ChAd155-RSV did not induce significant IP and A pathology scores. The low levels of IP and A observed were consistent with what has been observed during RSV acute infection and secondary RSV re-infection [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006; 118: 1774-93.

[0443] Boukhvalova, 2013], and were comparable to values observed with PanAd3-RSV in previous studies.

[0444] In FIG. 16, dashed horizontal lines represent limit of detection (LOD) for each assay in panels A, B and C. In panel D The dashed horizontal line (set at 5%) represents the threshold for significant pathology.

[0445] 5.2.3--Seronegative Calves

[0446] Bovine RSV (bRSV) causes respiratory disease in young calves that is very similar to that observed in human infants. In addition, bovine RSV is genetically and antigenically related to human RSV. The newborn calf bRSV model a relevant animal model for evaluation of safety of human RSV vaccines

[0447] Methodology

[0448] Three groups of five colostrum-restricted calves were vaccinated on two occasions, four weeks apart, with 5.times.10.sup.10 vp ChAd155-RSV or comparator PanAd3-RSV, as indicated in Table 6.

TABLE-US-00008 TABLE 6 Dosing scheme of newborn calves Group Vaccination 1 Dose Vaccination 2 Dose A PanAd3-RSV IM 5 .times. 10.sup.10 vp PanAd3-RSV IM 5 .times. 10.sup.10 vp B ChAd155-RSV IM 5 .times. 10.sup.10 vp ChAd155-RSV IM 5 .times. 10.sup.10 vp C PanAd3-control IM 5 .times. 10.sup.10 vp PanAd3-control IM 5 .times. 10.sup.10 vp

[0449] Group C was mock-vaccinated with PanAd3 adenovectors containing unrelated antigens. The animals were challenged four weeks after the second vaccination by IN (10 mL) and intratracheal (IT) (10 mL) administration of 10.sup.4 pfu of bRSV Snook strain. Six days after the infection, when the virus replication peaked in the lung and in the nose causing maximal pulmonary pathology, the animals were sacrificed. In this model, due to the IN/IT routes of administration of the challenge inoculum, very few, if any, clinical signs are observed in challenged control animals. Therefore, the effects of vaccination on bRSV challenge were studied by nasopharyngeal excretion of bRSV, analysis of levels of bRSV in lung homogenate, development of gross pneumonic lesions and analysis of leukocytes in broncho-alveolar lavage (BAL). Antibody responses (antibody and neutralizing titers) induced after vaccination and/or challenge were also investigated.

[0450] Immunogenicity Results

[0451] Effect of Vaccination on Induction of bRSV-Specific Serum IgG

[0452] Kinetics of the mean bRSV-specific serum IgG antibody and human RSV (hRSV) neutralizing titers throughout the course of the vaccination are shown per study group in FIG. 17. The graph shows the geometric mean value of each study group. Levels of bRSV-specific IgG were determined using bRSV (Snook strain)-infected fetal calf kidney (FCK) cell lysate as antigen [Taylor, 1995]. A lysate of mock-infected FCK cells was used as a control antigen.

[0453] Two out of five animals in each group receiving an RSV immunogen showed low levels of maternal bRSV-specific antibodies at the start of the vaccination. Nevertheless, all animals responded to the vaccines and reached high levels (log.sub.10=3-3.5) of bRSV-specific antibodies after the boost (FIG. 17A). All the calves in the control group had detectable bRSV-specific antibodies at the start of the vaccination which declined during the study and were not detectable on the day of the challenge. In conclusion, PanAd3-RSV and ChAd155-RSV displayed similar potency in eliciting antibody responses.

[0454] No hRSV neutralizing response could be detected before vaccination. After a single dose, all animals vaccinated with PanAd3-RSV and 2 out of 5 animals vaccinated with ChAd155-RSV had measurable RSV neutralizing antibodies (FIG. 17B). A marked boost was observed after the second dose for both vaccines. No further enhancement of the hRSV neutralizing response was observed 1 week after challenge.

[0455] Efficacy Results

[0456] Effect of Vaccination on Nasopharyngeal Excretion of bRSV

[0457] Following bRSV challenge, nasopharynx swabs were obtained daily and the bRSV titers within the samples determined. As shown in FIG. 18, titers in the control group increased from day 3 to day 6. bRSV replication appeared to be significantly reduced in calves that had received either of the adenovector RSV constructs.

[0458] Effect of Vaccination on Replication of bRSV in the Lower Respiratory Tract.

[0459] Six days after bRSV challenge, high titers of bRSV were detected in lung wash cells (LWC) and lung lobe homogenates (RA, RC and LC) of all of the control calves, and from tracheal scrape (TSc) samples in 5 out of 6 of the control calves (FIG. 19). In contrast, bRSV was detected at low titers from the TSc samples of 2 and from LWC of 1 of the calves which received ChAd155-RSV, while it was undetectable in all samples from the calves which received PanAd3-RSV.

[0460] Effect of Vaccination on Pulmonary Pathology

[0461] Six days after bRSV challenge, extensive gross pneumonic consolidation was observed in 6 out of 6 control calves (FIG. 20). In contrast, there was little or no gross pneumonic consolidation in the calves that had received either of the adenovector RSV constructs. FIG. 21 quantifies the mean proportion.+-.SD of lymphocytes (L), macrophages (Mo), polymorphonuclear leukocytes (PMN) and eosinophils (Eo) in BAL, 6 days after bRSV challenge. Approximately 70% of the cells in BAL from control calves were PMN. A lower proportion of PMN was found in BAL from calves which received ChAd155-RSV or PanAd3-RSV, indicating a reduced pulmonary inflammation. Importantly, eosinophils were very few or undetectable in the lungs of calves which received ChAd155-RSV or PanAd3-RSV suggesting the absence of vaccine-induced disease exacerbation.

[0462] Conclusion

[0463] Taken together the results reported above demonstrated that ChAd155 is an improved adenoviral vector in comparison to ChAd3 and PanAd3 vectors. ChAd155 was shown to be more productive therefore facilitating the manufacture process, able to express higher level of transgene in vitro and also in vivo providing a stronger T-cell response and at least as potent an antibody response against the antigens expressed in animal models. Protective immunity is achieved without signs of vaccine-induced enhanced pulmonary pathology.

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TABLE-US-00009 DESCRIPTION OF THE SEQUENCES Polypeptide sequence of ChAd155 fiber SEQ ID NO: 1 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI NETFQTNSFTFSYIAQE Polynucleotide sequence encoding ChAd155 fiber SEQ ID NO: 2 ATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCC CTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGG TCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAA Polypeptide sequence of ChAd155 penton SEQ ID NO: 3 MRRAAMYQEGPPPSYESVVGAAAAAPSSPFASQLLEPPYVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLV DNKSADVASLNYQNDHSNFLTTVIQNNDYSPSEASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTN KFKARVMVSRSHTKEDRVELKYEWVEFELPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKF DTRNFRLGLDPVTGLVMPGVYTNEAFHPDIILLPGCGVDFTYSRLSNLLGIRKRQPFQEGFRITYEDLEGG NIPALLDVEAYQDSLKENEAGQEDTAPAASAAAEQGEDAADTAAADGAEADPAMVVEAPEQEEDMNDS AVRGDTFVTRGEEKQAEAEAAAEEKQLAAAAAAAALAAAEAESEGTKPAKEPVIKPLTEDSKKRSYNLL KDSTNTAYRSWYLAYNYGDPSTGVRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQVSNFPVV GAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVSENVPALTDHGTLPLRNSIG GVQRVTVTDARRRTCPYVYKALGIVSPRVLSSRTF Polynucleotide sequence encoding ChAd155 penton SEQ ID NO: 4 ATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGG CGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTG CGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGG TGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTT TTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTG GATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAAC GAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACC GGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGA CCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCT GGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGG GCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCG GGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGA GGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCC TACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCC GCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATG GTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTC ACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGC AGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCC CGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAA CACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGG ACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGA TGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCT GCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCA CCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACC ATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCA TCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGC CTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTT Polypeptide sequence of ChAd155 hexon SEQ ID NO: 5 MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATDSYFSLSNKFRNPTVAPTHDVTTDRSQRLTLRFIP VDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTAYNSLAPKGAPNSCEWEQEE TQTAEEAQDEEEDEAEAEEEMPQEEQAPVKKTHVYAQAPLSGEKITKDGLQIGTDATATEQKPIYADPTF QPEPQIGESQWNEADASVAGGRVLKKTTPMKPCYGSYARPTNANGGQGVLVEKDGGKMESQVDMQFFS TSENARNEANNIQPKLVLYSEDVHMETPDTHISYKPAKSDDNSKVMLGQQSMPNRPNYIGFRDNFIGLMY YNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSMGDRTRYFSMWNQAVDSYDPDVRIIENHGT EDELPNYCFPLGGIGVTDTYQAIKTNGNGNGGGNTTWTKDETFADRNEIGVGNNFAMEINLSANLWRNF LYSNVALYLPDKLKYNPSNVEISDNPNTYDYMNKRVVAPGLVDCYINLGARWSLDYMDNVNPFNHHRN AGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWNFRKDVNMVLQSSLGNDLRVDGASIKF ESICLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAF TRLKTKETPSLGSGFDPYYTYSGSIPYLDGTFYLNHTFKKVSVTFDSSVSWPGNDRLLTPNEFEIKRSVDGE GYNVAQCNMTKDWFLIQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDETKYKDYQQVGII HQHNNSGFVGYLAPTMREGQAYPANFPYPLIGKTAVDSVTQKKFLCDRTLWRIPFSSNFMSMGALTDLG QNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQPHRGVIETVYLRTPFSAGNATT Polynucleotide sequence encoding ChAd155 hexon SEQ ID NO: 6 ATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGT ACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTT TAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGG TTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCG ACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCAC TTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGT GGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGT CAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCG AAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTT ATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTAC AGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGA CCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAG GTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATT GGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAA AGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCT TCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCA GGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTG CTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACC CAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGT GGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTG ACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGG AGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGA CAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAAC AAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACT ACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCT GGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTC CTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGA GCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGC CACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAAC GACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAA CGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGA CCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTAC CTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAG CTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAG

GGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACA ACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAA CTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCAT CATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCC TACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGT TCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCG GACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACC CCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCG CACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACC Polynucleotide sequence encoding ChAd155#1434 backbone construct SEQ ID NO: 7 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG

CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC

CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC

GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA

AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACTAGTG GAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTGGTGCTGCAG CAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCAGTGGTCTCC TCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGCGCACCCTGA TCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAA GGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAG GTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCATGTTGTAAT TCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATCCTAAACCAG CTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGACAGTGGAGA GCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACA CGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCA TTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGTGCATTGTC AAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGTCTCAAAAG GAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGTAGTGTCAT GCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGCACCAGCAC CAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAA CGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAA AAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAA CAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCG GCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGC TTCAATCCAAAATAAGGTATATTATTGATGATGGTTTAAACGGATCCAATTCTTGAAGACGAAAGGG CCTCGTGATACGCCTATTTTTATAGGTTAATGTCATGATAATAATGGTTTCTTAGACGTCAGGTGGCA CTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGC TCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACA TTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTG GTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACA GCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTG CTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATT CTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAG AGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATC GGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTT GGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGG CAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGA CTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTG CTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAA GCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAG ATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATACT TTAGATTGATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACG TGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTT TTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGAT CAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCC TTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTG CTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACG ATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGA GCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGA AGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGC TTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGA TTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGT TCCTGGCCTTTTGCTGGCCTTGAAGCTGTCCCTGATGGTCGTCATCTACCTGCCTGGACAGCATGGCC TGCAACGCGGGCATCCCGATGCCGCCGGAAGCGAGAAGAATCATAATGGGGAAGGCCATCCAGCCT CGCGTCGCAGATCCGAATTCGTTTAAAC Polynucleotide sequence encoding ChAd155#1390 backbone construct SEQ ID NO: 8 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT

CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA

ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG

AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG

GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACTAGTG GAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTGGTGCTGCAG CAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCAGTGGTCTCC TCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGCGCACCCTGA TCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAA GGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAG GTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCATGTTGTAAT TCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATCCTAAACCAG CTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGACAGTGGAGA GCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACA CGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCA TTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGTGCATTGTC AAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGTCTCAAAAG GAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGTAGTGTCAT GCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGCACCAGCAC CAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAA CGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAA AAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAA CAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCG GCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGC TTCAATCCAAAATAAGGTATATTATTGATGATGGTTTAAACGGATCCTCTAGAGTCGACCTGCAGGC ATGCAAGCTTGAGTATTCTATAGTGTCACCTAAATAGCTTGGCGTAATCATGGTCATAGCTGTTTCCT GTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCT GGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGAACCCCTTGCGGCCGCCCGGGCCGTCG ACCAATTCTCATGTTTGACAGCTTATCATCGAATTTCTGCCATTCATCCGCTTATTATCACTTATTCAG GCGTAGCAACCAGGCGTTTAAGGGCACCAATAACTGCCTTAAAAAAATTACGCCCCGCCCTGCCACT CATCGCAGTACTGTTGTAATTCATTAAGCATTCTGCCGACATGGAAGCCATCACAAACGGCATGATG AACCTGAATCGCCAGCGGCATCAGCACCTTGTCGCCTTGCGTATAATATTTGCCCATGGTGAAAACG GGGGCGAAGAAGTTGTCCATATTGGCCACGTTTAAATCAAAACTGGTGAAACTCACCCAGGGATTGG CTGAGACGAAAAACATATTCTCAATAAACCCTTTAGGGAAATAGGCCAGGTTTTCACCGTAACACGC CACATCTTGCGAATATATGTGTAGAAACTGCCGGAAATCGTCGTGGTATTCACTCCAGAGCGATGAA AACGTTTCAGTTTGCTCATGGAAAACGGTGTAACAAGGGTGAACACTATCCCATATCACCAGCTCAC CGTCTTTCATTGCCATACGGAATTCCGGATGAGCATTCATCAGGCGGGCAAGAATGTGAATAAAGGC CGGATAAAACTTGTGCTTATTTTTCTTTACGGTCTTTAAAAAGGCCGTAATATCCAGCTGAACGGTCT GGTTATAGGTACATTGAGCAACTGACTGAAATGCCTCAAAATGTTCTTTACGATGCCATTGGGATATA TCAACGGTGGTATATCCAGTGATTTTTTTCTCCATTTTAGCTTCCTTAGCTCCTGAAAATCTCGATAAC

TCAAAAAATACGCCCGGTAGTGATCTTATTTCATTATGGTGAAAGTTGGAACCTCTTACGTGCCGATC AACGTCTCATTTTCGCCAAAAGTTGGCCCAGGGCTTCCCGGTATCAACAGGGACACCAGGATTTATTT ATTCTGCGAAGTGATCTTCCGTCACAGGTATTTATTCGCGATAAGCTCATGGAGCGGCGTAACCGTCG CACAGGAAGGACAGAGAAAGCGCGGATCTGGGAAGTGACGGACAGAACGGTCAGGACCTGGATTG GGGAGGCGGTTGCCGCCGCTGCTGCTGACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTC CGCCATTCCTATGCGATGCACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGG GACATAAGTCCATCAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCA CCGGGTGCAGTTTGCGATGCCGGAGTCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAATAA ATGCCTTGGCCTTTATATGGAAATGTGGAACTGAGTGGATATGCTGTTTTTGTCTGTTAAACAGAGAA GCTGGCTGTTATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTCCCATTATCGTAGAGATCCG CATTATTAATCTCAGGAGCCTGTGTAGCGTTTATAGGAAGTAGTGTTCTGTCATGATGCCTGCAAGCG GTAACGAAAACGATTTGAATATGCCTTCAGGAACAATAGAAATCTTCGTGCGGTGTTACGTTGAAGT GGAGCGGATTATGTCAGCAATGGACAGAACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCT TTTACAGCCAGTAGTGCTCGCCGCAGTCGAGCGACAGGGCGAAGCCCTCGAGTGAGCGAGGAAGCA CCAGGGAACAGCACTTATATATTCTGCTTACACACGATGCCTGAAAAAACTTCCCTTGGGGTTATCCA CTTATCCACGGGGATATTTTTATAATTATTTTTTTTATAGTTTTTAGATCTTCTTTTTTAGAGCGCCTTG TAGGCCTTTATCCATGCTGGTTCTAGAGAAGGTGTTGTGACAAATTGCCCTTTCAGTGTGACAAATCA CCCTCAAATGACAGTCCTGTCTGTGACAAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAA GCTGTTTTTTCACAAAGTTATCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTG TCACACTTCACATGGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGC CCGCGAATCGTCCAGTCAAACGACCTCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAACGTA TGCTGTATCTGTTCGTTGACCAGATCAGAAAATCTGATGGCACCCTACAGGAACATGACGGTATCTG CGAGATCCATGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCGGAAGCCAGTAAGGATATA CGGCAGGCATTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTTATCGCCCTGAAGAGGATGCCGGCG ATGAAAAAGGCTATGAATCTTTTCCTTGGTTTATCAAACGTGCGCACAGTCCATCCAGAGGGCTTTAC AGTGTACATATCAACCCATATCTCATTCCCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCG GCTTAGTGAAACAAAAGAAATCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTAT CGTAAGCCGGATGGCTCAGGCATCGTCTCTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGC CTCAAAGTTACCAGCGTATGCCTGACTTCCGCCGCCGCTTCCTGCAGGTCTGTGTTAATGAGATCAAC AGCAGAACTCCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAGACGACTCATATCGTAT TTTCCTTCCGCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATCTGTCACAGATTTGAGGG TGGTTCGTCACATTTGTTCTGACCTACTGAGGGTAATTTGTCACAGTTTTGCTGTTTCCTTCAGCCTGC ATGGATTTTCTCATACTTTTTGAACTGTAATTTTTAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAG TTGATTTCCTTCTCTTTCCCTTCGTCATGTGACCTGATATCGGGGGTTAGTTCGTCATCATTGATGAGG GTTGATTATCACAGTTTATTACTCTGAATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCA CGGTGGATATTTCTTCTTGCGCTGAGCGTAAGAGCTATCTGACAGAACAGTTCTTCTTTGCTTCCTCG CCAGTTCGCTCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGTGATAATAAGTGACTGAGGTA TGTGCTCTTCTTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGCGGTTTTTTGATGACTTT GCGATTTTGTTGTTGCTTTGCAGTAAATTGCAAGATTTAATAAAAAAACGCAAAGCAATGATTAAAG GATGTTCAGAATGAAACTCATGGAAACACTTAACCAGTGCATAAACGCTGGTCATGAAATGACGAAG GCTATCGCCATTGCACAGTTTAATGATGACAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGA ATAGGTGAAGCAGCGGATTTAGTTGGGGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGC GACTACCGCACCCGGATATGGAAATTCGAGGACGGGTTGAGCAACGTGTTGGTTATACAATTGAACA AATTAATCATATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAGACGTATTTCCACCGGTGA TCGGGGTTGCTGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCAGGATCTG GCTCTGAAGGGGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAACAGCCTCAATGTATC ACGGATGGGTACCAGATCTTCATATTCATGCAGAAGACACTCTCCTGCCTTTCTATCTTGGGGAAAAG GACGATGTCACTTATGCAATAAAGCCCACTTGCTGGCCGGGGCTTGACATTATTCCTTCCTGTCTGGC TCTGCACCGTATTGAAACTGAGTTAATGGGCAAATTTGATGAAGGTAAACTGCCCACCGATCCACAC CTGATGCTCCGACTGGCCATTGAAACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCC TAACCTGGGTATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGTTCCCACGCCTGCTG AGTTGTTTGACTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAACGTTGAT CTTAAAGGGTTCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGTAATGGCTCTCAGTC CCCGTGGATGGAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAAAAATGTTGTACGTGAA ACGGATGAAGTTGGTAAAGGTCAGATCCGGATGAGAACTGTTTTTGAACAGGCCATTGATCAACGCT CTTCAACTGGTGCCTGGAGAAATGCTCTTTCTATTTGGGAACCTGTCTGCAATGAAATTTTCGATCGT CTGATTAAACCACGCTGGGAGATTAGATAATGAAGCGTGCGCCTGTTATTCCAAAACATACGCTCAA TACTCAACCGGTTGAAGATACTTCGTTATCGACACCAGCTGCCCCGATGGTGGATTCGTTAATTGCGC GCGTAGGAGTAATGGCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAGTTTACT CTTGAAGTGCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGACC AGGAGCTGCTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGTCAACAGACA CCGGCGTTCGGTCGAAGAGTATCTGGTGTCATAGAAATTGCCGATGGGAGTCGCCGTCGTAAAGCTG CTGCACTTACCGAAAGTGATTATCGTGTTCTGGTTGGCGAGCTGGATGATGAGCAGATGGCTGCATT ATCCAGATTGGGTAACGATTATCGCCCAACAAGTGCTTATGAACGTGGTCAGCGTTATGCAAGCCGA TTGCAGAATGAATTTGCTGGAAATATTTCTGCGCTGGCTGATGCGGAAAATATTTCACGTAAGATTAT TACCCGCTGTATCAACACCGCCAAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGTGAACT ATCTGCCCGGTCAGGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAG GCATCTAACCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTTT TAACTTCTGTGCTTAAAACGTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAGTTTGCTCCT GGAGCGACAGTATTGTATAAGGGCGATAAAATGGTGCTTAACCTGGACAGGTCTCGTGTTCCAACTG AGTGTATAGAGAAAATTGAGGCCATTCTTAAGGAACTTGAAAAGCCAGCACCCTGATGCGACCACGT TTTAGTCTACGTTTATCTGTCTTTACTTAATGTCCTTTGTTACAGGCCAGAAAGCATAACTGGCCTGAA TATTCTCTCTGGGCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCA CTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAG TCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTAT CGTCGGTCTGATTATTAGTCTGGGACCATGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGA CCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGAACCACGGTCCCACTCGTATCGTCGGT CTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGAT CCCACTCGTGTTGTCGGTCTGATTATCGGTCTGGGACCACGGTCCCACTTGTATTGTCGATCAGACTA TCAGCGTGAGACTACGATTCCATCAATGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGT AGAACGGAGTAACCTCGGTGTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCAC AACATTTTGCGCACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGG GCTGCATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCGTAT TCAGTGTCGCTGATTTGTATTGTCTGAAGTTGTTTTTACGTTAAGTTGATGCAGATCAATTAATACGAT ACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCACGTTGTGATATGTAGATGAT AATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACAGGTTACGGGGCGGCGACCTCGCGGGTTT TCGCTATTTATGAAAATTTTCCGGTTTAAGGCGTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATT TAAAATACCCTCTGAAAAGAAAGGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTT CCTTTCTCTGTTTTTGTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAG CATACATTATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAA ATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACT GTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGC AAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAA TTGTAATACGACTCACTATAGGGCGAATTCGAGCTCGGTACCCGGGGATCCTCGTTTAAAC Polynucleotide sequence encoding ChAd155#1375 backbone construct SEQ ID NO: 9 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG

CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC

GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG

CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC

CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAGATCAGA CAGTGATAATTAACCACCACCACCACCATACCTTTTGATTCAGGAAATCATGATCATCACAGGATCCT AGTCTTCAGGCCGCCCCCTCCCTCCCAAGACACAGAATACACAGTCCTCTCCCCCCGACTGGCTTTAA ATAACACCATCTGGTTGGTCACAGACATGTTCTTAGGGGTTATATTCCACACGGTCTCCTGCCGCGCC AGGCGCTCGTCGGTGATGTTGATAAACTCTCCCGGCAGCTCGCTCAAGTTCACGTCGCTGTCCAGCGG CTGAACCTCCGGCTGACGCGATAACTGTGCGACCGGCTGCTGGACGAACGGAGGCCGCGCCTACAAG GGGGTAGAGTCATAATCCTCGGTCAGGATAGGGCGGTGATGCAGCAGCAGCGAGCGAAACATCTGC TGCCGCCGCCGCTCCGTCCGGCAGGAAAACAACACGCCGGTGGTCTCCTCCGCGATAATCCGCACCG CCCGCAGCATCAGCTTCCTCGTTCTCCGCGCGCAGCACCTCACCCTTATCTCGCTCAAATCGGCGCAG TAGGTACAGCACAGCACCACGATGTTATTCATGATCCCACAGTGCAGGGCGCTGTATCCAAAGCTCA TGCCGGGAACCACCGCCCCCACGTGGCCATCGTACCACAAGCGCACGTAAATCAAGTGTCGACCCCT CATGAACGCGCTGGACACAAACATTACTTCCTTGGGCATGTTGTAATTCACCACCTCCCGGTACCAGA TAAACCTCTGGTTGAACAGGGCACCTTCCACCACCATCCTGAACCAAGAGGCCAGAACCTGCCCACC GGCTATGCACTGCAGGGAACCCGGGTTGGAACAATGACAATGCAGACTCCAAGGCTCGTAACCGTG GATCATCCGGCTGCTGAAGGCATCGATGTTGGCACAACACAGACACACGTGCATGCACTTTCTCATG ATTAGCAGCTCTTCCCTCGTCAGGATCATATCCCAAGGAATAACCCATTCTTGAATCAACGTAAAACC CACACAGCAGGGAAGGCCTCGCACATAACTCACGTTGTGCATGGTCAGCGTGTTGCATTCCGGAAAC

AGCGGATGATCCTCCAGTATCGAGGCGCGGGTCTCCTTCTCACAGGGAGGTAAAGGGTCCCTGCTGT ACGGACTGCGCCGGGACGACCGAGATCGTGTTGAGCGTAGTGTCATGGAAAAGGGAACGCCGGACG TGGTCATACTTCTTGAAGCAGAACCAGGTTCGCGCGTGGCAGGCCTCCTTGCGTCTGCGGTCTCGCCG TCTAGCTCGCTCCGTGTGATAGTTGTAGTACAGCCACTCCCGCAGAGCGTCGAGGCGCACCCTGGCTT CCGGATCTATGTAGACTCCGTCTTGCACCGCGGCCCTGATAATATCCACCACCGTAGAATAAGCAAC ACCCAGCCAAGCAATACACTCGCTCTGCGAGCGGCAGACAGGAGGAGCGGGCAGAGATGGGAGAAC CATGATAAAAAACTTTTTTTAAAGAATATTTTCCAATTCTTCGAAAGTAAGATCTATCAAGTGGCAGC GCTCCCCTCCACTGGCGCGGTCAAACTCTACGGCCAAAGCACAGACAACGGCATTTCTAAGATGTTC CTTAATGGCGTCCAAAAGACACACCGCTCTCAAGTTGCAGTAAACTATGAATGAAAACCCATCCGGC TGATTTTCCAATATAGACGCGCCGGCAGCGTCCACCAAACCCAGATAATTTTCTTCTCTCCAGCGGTT TACGATCTGTCTAAGCAAATCCCTTATATCAAGTCCGACCATGCCAAAAATCTGCTCAAGAGCGCCCT CCACCTTCATGTACAAGCAGCGCATCATGATTGCAAAAATTCAGGTTCTTCAGAGACCTGTATAAGA TTCAAAATGGGAACATTAACAAAAATTCCTCTGTCGCGCAGATCCCTTCGCAGGGCAAGCTGAACAT AATCAGACAGGTCCGAACGGACCAGTGAGGCCAAATCCCCACCAGGAACCAGATCCAGAGACCCTA TACTGATTATGACGCGCATACTCGGGGCTATGCTGACCAGCGTAGCGCCGATGTAGGCGTGCTGCAT GGGCGGCGAGATAAAATGCAAAGTGCTGGTTAAAAAATCAGGCAAAGCCTCGCGCAAAAAAGCTAA CACATCATAATCATGCTCATGCAGGTAGTTGCAGGTAAGCTCAGGAACCAAAACGGAATAACACACG ATTTTCCTCTCAAACATGACTTCGCGGATACTGCGTAAAACAAAAAATTATAAATAAAAAATTAATT AAATAACTTAAACATTGGAAGCCTGTCTCACAACAGGAAAAACCACTTTAATCAACATAAGACGGGC CACGGGCATGCCGGCATAGCCGTAAAAAAATTGGTCCCCGTGATTAACAAGTACCACAGACAGCTCC CCGGTCATGTCGGGGGTCATCATGTGAGACTCTGTATACACGTCTGGATTGTGAACATCAGACAAAC AAAGAAATCGAGCCACGTAGCCCGGAGGTATAATCACCCGCAGGCGGAGGTACAGCAAAACGACCC CCATAGGAGGAATCACAAAATTAGTAGGAGAAAAAAATACATAAACACCAGAAAAACCCTGTTGCT GAGGCAAAATAGCGCCCTCCCGATCCAAAACAACATAAAGCGCTTCCACAGGAGCAGCCATAACAA AGACCCGAGTCTTACCAGTAAAAGAAAAAAGATCTCTCAACGCAGCACCAGCACCAACACTTCGCA GTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAACGGGCAAAGTCC AAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAAAAACACTAGAC ACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAACAAACTACATA TCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCGGCCCGCCCCCA AACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGCTTCAATCCAAA ATAAGGTATATTATTGATGATGGTTTAAACGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTG AGTATTCTATAGTGTCACCTAAATAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTG TTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAA TGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTG CCAGCTGCATTAATGAATCGGCCAACGCGAACCCCTTGCGGCCGCCCGGGCCGTCGACCAATTCTCA TGTTTGACAGCTTATCATCGAATTTCTGCCATTCATCCGCTTATTATCACTTATTCAGGCGTAGCAACC AGGCGTTTAAGGGCACCAATAACTGCCTTAAAAAAATTACGCCCCGCCCTGCCACTCATCGCAGTAC TGTTGTAATTCATTAAGCATTCTGCCGACATGGAAGCCATCACAAACGGCATGATGAACCTGAATCG CCAGCGGCATCAGCACCTTGTCGCCTTGCGTATAATATTTGCCCATGGTGAAAACGGGGGCGAAGAA GTTGTCCATATTGGCCACGTTTAAATCAAAACTGGTGAAACTCACCCAGGGATTGGCTGAGACGAAA AACATATTCTCAATAAACCCTTTAGGGAAATAGGCCAGGTTTTCACCGTAACACGCCACATCTTGCG AATATATGTGTAGAAACTGCCGGAAATCGTCGTGGTATTCACTCCAGAGCGATGAAAACGTTTCAGT TTGCTCATGGAAAACGGTGTAACAAGGGTGAACACTATCCCATATCACCAGCTCACCGTCTTTCATTG CCATACGGAATTCCGGATGAGCATTCATCAGGCGGGCAAGAATGTGAATAAAGGCCGGATAAAACT TGTGCTTATTTTTCTTTACGGTCTTTAAAAAGGCCGTAATATCCAGCTGAACGGTCTGGTTATAGGTA CATTGAGCAACTGACTGAAATGCCTCAAAATGTTCTTTACGATGCCATTGGGATATATCAACGGTGGT ATATCCAGTGATTTTTTTCTCCATTTTAGCTTCCTTAGCTCCTGAAAATCTCGATAACTCAAAAAATAC GCCCGGTAGTGATCTTATTTCATTATGGTGAAAGTTGGAACCTCTTACGTGCCGATCAACGTCTCATT TTCGCCAAAAGTTGGCCCAGGGCTTCCCGGTATCAACAGGGACACCAGGATTTATTTATTCTGCGAA GTGATCTTCCGTCACAGGTATTTATTCGCGATAAGCTCATGGAGCGGCGTAACCGTCGCACAGGAAG GACAGAGAAAGCGCGGATCTGGGAAGTGACGGACAGAACGGTCAGGACCTGGATTGGGGAGGCGGT TGCCGCCGCTGCTGCTGACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTCCGCCATTCCT ATGCGATGCACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGGGACATAAGTC CATCAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCACCGGGTGCAG TTTGCGATGCCGGAGTCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAATAAATGCCTTGGC CTTTATATGGAAATGTGGAACTGAGTGGATATGCTGTTTTTGTCTGTTAAACAGAGAAGCTGGCTGTT ATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTCCCATTATCGTAGAGATCCGCATTATTAAT CTCAGGAGCCTGTGTAGCGTTTATAGGAAGTAGTGTTCTGTCATGATGCCTGCAAGCGGTAACGAAA ACGATTTGAATATGCCTTCAGGAACAATAGAAATCTTCGTGCGGTGTTACGTTGAAGTGGAGCGGAT TATGTCAGCAATGGACAGAACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCTTTTACAGCC AGTAGTGCTCGCCGCAGTCGAGCGACAGGGCGAAGCCCTCGAGTGAGCGAGGAAGCACCAGGGAAC AGCACTTATATATTCTGCTTACACACGATGCCTGAAAAAACTTCCCTTGGGGTTATCCACTTATCCAC GGGGATATTTTTATAATTATTTTTTTTATAGTTTTTAGATCTTCTTTTTTAGAGCGCCTTGTAGGCCTTT ATCCATGCTGGTTCTAGAGAAGGTGTTGTGACAAATTGCCCTTTCAGTGTGACAAATCACCCTCAAAT GACAGTCCTGTCTGTGACAAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAAGCTGTTTTTT CACAAAGTTATCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTGTCACACTTCA CATGGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGCCCGCGAATC GTCCAGTCAAACGACCTCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAACGTATGCTGTATC TGTTCGTTGACCAGATCAGAAAATCTGATGGCACCCTACAGGAACATGACGGTATCTGCGAGATCCA TGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCGGAAGCCAGTAAGGATATACGGCAGGCA TTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTTATCGCCCTGAAGAGGATGCCGGCGATGAAAAAG GCTATGAATCTTTTCCTTGGTTTATCAAACGTGCGCACAGTCCATCCAGAGGGCTTTACAGTGTACAT ATCAACCCATATCTCATTCCCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCGGCTTAGTGA AACAAAAGAAATCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTATCGTAAGCCG GATGGCTCAGGCATCGTCTCTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGCCTCAAAGTT ACCAGCGTATGCCTGACTTCCGCCGCCGCTTCCTGCAGGTCTGTGTTAATGAGATCAACAGCAGAACT CCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAGACGACTCATATCGTATTTTCCTTCC GCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATCTGTCACAGATTTGAGGGTGGTTCGTC ACATTTGTTCTGACCTACTGAGGGTAATTTGTCACAGTTTTGCTGTTTCCTTCAGCCTGCATGGATTTT CTCATACTTTTTGAACTGTAATTTTTAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAGTTGATTTCC TTCTCTTTCCCTTCGTCATGTGACCTGATATCGGGGGTTAGTTCGTCATCATTGATGAGGGTTGATTAT CACAGTTTATTACTCTGAATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCACGGTGGAT ATTTCTTCTTGCGCTGAGCGTAAGAGCTATCTGACAGAACAGTTCTTCTTTGCTTCCTCGCCAGTTCGC TCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGTGATAATAAGTGACTGAGGTATGTGCTCTTC TTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGCGGTTTTTTGATGACTTTGCGATTTTGT TGTTGCTTTGCAGTAAATTGCAAGATTTAATAAAAAAACGCAAAGCAATGATTAAAGGATGTTCAGA ATGAAACTCATGGAAACACTTAACCAGTGCATAAACGCTGGTCATGAAATGACGAAGGCTATCGCCA TTGCACAGTTTAATGATGACAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGAATAGGTGAAG CAGCGGATTTAGTTGGGGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGCGACTACCGCA CCCGGATATGGAAATTCGAGGACGGGTTGAGCAACGTGTTGGTTATACAATTGAACAAATTAATCAT ATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAGACGTATTTCCACCGGTGATCGGGGTTGC TGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCAGGATCTGGCTCTGAAGG GGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAACAGCCTCAATGTATCACGGATGGGT ACCAGATCTTCATATTCATGCAGAAGACACTCTCCTGCCTTTCTATCTTGGGGAAAAGGACGATGTCA CTTATGCAATAAAGCCCACTTGCTGGCCGGGGCTTGACATTATTCCTTCCTGTCTGGCTCTGCACCGT ATTGAAACTGAGTTAATGGGCAAATTTGATGAAGGTAAACTGCCCACCGATCCACACCTGATGCTCC GACTGGCCATTGAAACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCCTAACCTGGGT ATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGTTCCCACGCCTGCTGAGTTGTTTGA CTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAACGTTGATCTTAAAGGGT TCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGTAATGGCTCTCAGTCCCCGTGGATG GAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAAAAATGTTGTACGTGAAACGGATGAA GTTGGTAAAGGTCAGATCCGGATGAGAACTGTTTTTGAACAGGCCATTGATCAACGCTCTTCAACTG GTGCCTGGAGAAATGCTCTTTCTATTTGGGAACCTGTCTGCAATGAAATTTTCGATCGTCTGATTAAA CCACGCTGGGAGATTAGATAATGAAGCGTGCGCCTGTTATTCCAAAACATACGCTCAATACTCAACC GGTTGAAGATACTTCGTTATCGACACCAGCTGCCCCGATGGTGGATTCGTTAATTGCGCGCGTAGGA GTAATGGCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAGTTTACTCTTGAAGT GCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGACCAGGAGCTG CTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGTCAACAGACACCGGCGTT CGGTCGAAGAGTATCTGGTGTCATAGAAATTGCCGATGGGAGTCGCCGTCGTAAAGCTGCTGCACTT ACCGAAAGTGATTATCGTGTTCTGGTTGGCGAGCTGGATGATGAGCAGATGGCTGCATTATCCAGAT TGGGTAACGATTATCGCCCAACAAGTGCTTATGAACGTGGTCAGCGTTATGCAAGCCGATTGCAGAA TGAATTTGCTGGAAATATTTCTGCGCTGGCTGATGCGGAAAATATTTCACGTAAGATTATTACCCGCT GTATCAACACCGCCAAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGTGAACTATCTGCCC GGTCAGGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAGGCATCTAA CCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTTTTAACTTCTG TGCTTAAAACGTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAGTTTGCTCCTGGAGCGACA GTATTGTATAAGGGCGATAAAATGGTGCTTAACCTGGACAGGTCTCGTGTTCCAACTGAGTGTATAG AGAAAATTGAGGCCATTCTTAAGGAACTTGAAAAGCCAGCACCCTGATGCGACCACGTTTTAGTCTA CGTTTATCTGTCTTTACTTAATGTCCTTTGTTACAGGCCAGAAAGCATAACTGGCCTGAATATTCTCTC TGGGCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCG TCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACC ACGGTCCCACTCGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCGTCGGTCT GATTATTAGTCTGGGACCATGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCC CACTCGTATCGTCGGTCTGATTATTAGTCTGGAACCACGGTCCCACTCGTATCGTCGGTCTGATTATT AGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGATCCCACTCGT

GTTGTCGGTCTGATTATCGGTCTGGGACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGA GACTACGATTCCATCAATGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAG TAACCTCGGTGTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGC GCACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTGCATCCG ATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCGTATTCAGTGTCGC TGATTTGTATTGTCTGAAGTTGTTTTTACGTTAAGTTGATGCAGATCAATTAATACGATACCTGCGTC ATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCACGTTGTGATATGTAGATGATAATCATTAT CACTTTACGGGTCCTTTCCGGTGATCCGACAGGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTT ATGAAAATTTTCCGGTTTAAGGCGTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATAC CCTCTGAAAAGAAAGGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCT GTTTTTGTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACATTA TACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTG GCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCAC AGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAG GGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAATTGTAATAC GACTCACTATAGGGCGAATTCGAGCTCGGTACCCGGGGATCCTCGTTTAAAC Polynucleotide sequence encoding wild type ChAd155 SEQ ID NO: 10 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG GGAGGCGGGTCCGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGACTTTGTAAGTGTGG CGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGACAACGCCCACGGG AAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAACCAAGTAAGATTTG GCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTCGCGTTAGTCATACCGCG TAATATTTGTCGAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCAGGTGTTTTTTGAG GTGAATTTCCGCGTTCCGGGTCAAAGTCTCCGTTTTATTATTATAGTCAGCTGACGCGGAGTGTATTT ATACCCTCTGATCTCGTCAAGTGGCCACTCTTGAGTGCCAGCGAGTAGAGTTTTCTCCTCTGCCGCTC TCCGCTCCGCTCCGCTCGGCTCTGACACCGGGGAAAAAATGAGACATTTCACCTACGATGGCGGTGT GCTCACCGGCCAGCTGGCTGCTGAAGTCCTGGACACCCTGATCGAGGAGGTATTGGCCGATAATTAT CCTCCCTCGACTCCTTTTGAGCCACCTACACTTCACGAACTCTACGATCTGGATGTGGTGGGGCCCAG CGATCCGAACGAGCAGGCGGTTTCCAGTTTTTTTCCAGAGTCCATGTTGTTGGCCAGCCAGGAGGGG GTCGAACTTGAGACCCCTCCTCCGATCGTGGATTCCCCCGATCCGCCGCAGCTGACTAGGCAGCCCG AGCGCTGTGCGGGACCTGAGACTATGCCCCAGCTGCTACCTGAGGTGATCGATCTCACCTGTAATGA GTCTGGTTTTCCACCCAGCGAGGATGAGGACGAAGAGGGTGAGCAGTTTGTGTTAGATTCTGTGGAA CAACCCGGGCGAGGATGCAGGTCTTGTCAATATCACCGGAAAAACACAGGAGACTCCCAGATTATGT GTTCTCTGTGTTATATGAAGATGACCTGTATGTTTATTTACAGTAAGTTTATCATCTGTGGGCAGGTG GGCTATAGTGTGGGTGGTGGTCTTTGGGGGGTTTTTTAATATATGTCAGGGGTTATGCTGAAGACTTT TTTATTGTGATTTTTAAAGGTCCAGTGTCTGAGCCCGAGCAAGAACCTGAACCGGAGCCTGAGCCTTC TCGCCCCAGGAGAAAGCCTGTAATCTTAACTAGACCCAGCGCACCGGTAGCGAGAGGCCTCAGCAGC GCGGAGACCACCGACTCCGGTGCTTCCTCATCACCCCCGGAGATTCACCCCCTGGTGCCCCTGTGTCC CGTTAAGCCCGTTGCCGTGAGAGTCAGTGGGCGGCGGTCTGCTGTGGAGTGCATTGAGGACTTGCTT TTTGATTCACAGGAACCTTTGGACTTGAGCTTGAAACGCCCCAGGCATTAAACCTGGTCACCTGGACT GAATGAGTTGACGCCTATGTTTGCTTTTGAATGACTTAATGTGTATAGATAATAAAGAGTGAGATAAT GTTTTAATTGCATGGTGTGTTTAACTTGGGCGGAGTCTGCTGGGTATATAAGCTTCCCTGGGCTAAAC TTGGTTACACTTGACCTCATGGAGGCCTGGGAGTGTTTGGAGAACTTTGCCGGAGTTCGTGCCTTGCT GGACGAGAGCTCTAACAATACCTCTTGGTGGTGGAGGTATTTGTGGGGCTCTCCCCAGGGCAAGTTA GTTTGTAGAATCAAGGAGGATTACAAGTGGGAATTTGAAGAGCTTTTGAAATCCTGTGGTGAGCTAT TGGATTCTTTGAATCTAGGCCACCAGGCTCTCTTCCAGGAGAAGGTCATCAGGACTTTGGATTTTTCC ACACCGGGGCGCATTGCAGCCGCGGTTGCTTTTCTAGCTTTTTTGAAGGATAGATGGAGCGAAGAGA CCCACTTGAGTTCGGGCTACGTCCTGGATTTTCTGGCCATGCAACTGTGGAGAGCATGGATCAGACA CAAGAACAGGCTGCAACTGTTGTCTTCCGTCCGCCCGTTGCTGATTCCGGCGGAGGAGCAACAGGCC GGGTCAGAGGACCGGGCCCGTCGGGATCCGGAGGAGAGGGCACCGAGGCCGGGCGAGAGGAGCGC GCTGAACCTGGGAACCGGGCTGAGCGGCCATCCACATCGGGAGTGAATGTCGGGCAGGTGGTGGAT CTTTTTCCAGAACTGCGGCGGATTTTGACTATTAGGGAGGATGGGCAATTTGTTAAGGGTCTTAAGAG GGAGAGGGGGGCTTCTGAGCATAACGAGGAGGCCAGTAATTTAGCTTTTAGCTTGATGACCAGACAC CGTCCAGAGTGCATCACTTTTCAGCAGATTAAGGACAATTGTGCCAATGAGTTGGATCTGTTGGGTCA GAAGTATAGCATAGAGCAGCTGACCACTTACTGGCTGCAGCCGGGTGATGATCTGGAGGAAGCTATT AGGGTGTATGCTAAGGTGGCCCTGCGGCCCGATTGCAAGTACAAGCTCAAGGGGCTGGTGAATATCA GGAATTGTTGCTACATTTCTGGCAACGGGGCGGAGGTGGAGATAGAGACCGAAGACAGGGTGGCTTT CAGATGCAGCATGATGAATATGTGGCCGGGGGTGCTGGGCATGGACGGGGTGGTGATTATGAATGTG AGGTTCACGGGGCCCAACTTTAACGGCACGGTGTTTTTGGGGAACACCAACCTGGTCCTGCACGGGG TGAGCTTCTATGGGTTTAACAACACCTGTGTGGAGGCCTGGACCGATGTGAAGGTCCGCGGTTGCGC CTTTTATGGATGTTGGAAGGCCATAGTGAGCCGCCCTAAGAGCAGGAGTTCCATTAAGAAATGCTTG TTTGAGAGGTGCACCTTGGGGATCCTGGCCGAGGGCAACTGCAGGGTGCGCCACAATGTGGCCTCCG AGTGCGGTTGCTTCATGCTAGTCAAGAGCGTGGCGGTAATCAAGCATAATATGGTGTGCGGCAACAG CGAGGACAAGGCCTCACAGATGCTGACCTGCACGGATGGCAACTGCCACTTGCTGAAGACCATCCAT GTAACCAGCCACAGCCGGAAGGCCTGGCCCGTGTTCGAGCACAACTTGCTGACCCGCTGCTCCTTGC ATCTGGGCAACAGGCGGGGGGTGTTCCTGCCCTATCAATGCAACTTTAGTCACACCAAGATCTTGCT AGAGCCCGAGAGCATGTCCAAGGTGAACTTGAACGGGGTGTTTGACATGACCATGAAGATCTGGAA GGTGCTGAGGTACGACGAGACCAGGTCCCGGTGCAGACCCTGCGAGTGCGGGGGCAAGCATATGAG GAACCAGCCCGTGATGCTGGATGTGACCGAGGAGCTGAGGACAGACCACTTGGTTCTGGCCTGCACC AGGGCCGAGTTTGGTTCTAGCGATGAAGACACAGATTGAGGTGGGTGAGTGGGCGTGGCCTGGGGT GGTCATGAAAATATATAAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCC ATGAGCGGGAGCAGCAGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTAT TTGACGACGCGGATGCCCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCC GACCCGTCCTGCCCGCAAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGC CACCGCCGCCGCCGCCGCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTC CTGGGACCACTGGCGACAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGA CCGCCCTGCTGGCGCAGTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCC CTGCGCCAGCAGGTCTCCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATA AATAAAACCAGACTCTGTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTT TCCGCGCGCGATAGGCCCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGAC GTGGTAGAGGTGGCTCTGGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCA CCACTGCAGAGCTTCATGCTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCA TGGTGCCTAAAAATGTCCTTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTA CAAAACGGTTAAGTTGGGAAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAG ATTGGCGATGTTTCCGCCCAGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATC CGGTGCACTTGGGGAATTTGTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTT GTGGCCTCCCAGATTTTCCATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGG GCAAAGATATTTCTGGGGTCGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTT TACAAAGCGCGGGCGGAGGGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTG CCCTCGCAGATCTGCATTTCCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGA TGAAGAAAACGGTTTCCGGAGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTG ATTTTCCACAACCGGTGGGCCCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCT GCAGCTGCCGTCGTCCCGGAGGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCC CCGACCAGATCCGCCAGAAGGCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTT TCAGCGGCTTGAGGCCGTCCGCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCC CAGAGCTCGGTGACGTGCTCTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGA CTTTCGCTGTAGGGCACCAAGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCA GGGTCCTCGTCAGGGTGGTCTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGT GCGCTTGAGGCTGGTTCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGC ATTTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAG GTGGCGCCGCACGAGGGGCAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGAT TCGGGGGAGTAGGCGTCCGCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCT CGGGGCGCGCCGGGTCAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCC ATGAGGTGGTGTCCCCGCTCGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTC TTTTCTCCAGGGGGGTCCCTCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCG CGTCCAGGCCAGGACGAAGGAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCAC CTTCTCCAAGGTGTGAAGACACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGT AGGCCACGTGACCGGGGGTTCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCAC TCTCTTCCGCATCGCTGTCTGCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATG ACCTCCGCGCTGAGGTTGTCAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGA TACCTTTGAGGGTACCCGCGTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCG AACGACCCGTAGAGGGCGTTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGT CGGCGCGCTCCTTGGCCGCGATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAA GACGGTGGTGCGCTCGTCGGGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCC ACGCTGGTGGCGACCTCGCCGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGC AGAAGGGGGGCAGGGGGTCGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGG GGCGCAGGCGCGCGTCGAAGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCG GGCGGCGAGCGCGCGCTCGTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGA GGCGTACATGCCGCAGATGTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTA GCAGCGGCCGCCGCGGATGCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTC GGGGCCCAGGTTGGTGCGGGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGA GTTGGAAGAGATGGTGGGGCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCG CACGAAGGAGGCGTAGGAGTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGC GCAGTAGTCGAGGGTCTCGCGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGT TGAGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTA

AGAGCCTAGCATGTAGAACTGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCG TAGGCCTGCGCGGCCTTGCGGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGA GGTACTGGTGCTTGAAGTCGGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTT CTTGGAGCGGGGGTTGGGCAGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCAT GAAGTTGCGGGTGATGCGGAAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAG CACGATCTCGTCGAAGCCGTTGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCC TTTACGGTGGGCAGCTTCTTTAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGC CAGGGCCCAGTCCGCGAGGTGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAG GGTCTGCAGGCGGTCTCTGAAGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAG TAGAAGGTGAGGGGGTCTTGCTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCG GTGACCAGGCGCTCGTCGCCCCCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGG CCCCCATCCAAGTGTAGGTCTCTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCC GATCGGGAAGAACTGGATCTCCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAA GTCCCGTCGCCGGGCCGAACACTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGC ACGGGCTGTACCTCATGCACGAGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGA GCCCCCCGCCTGGCTCGCGGCATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCT CCTCGAGGGGTGTTACGGTGGAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGC GCGGCGGTCGGAGTTTGATGACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGG CGGCGGCAGGTCAGCCGGGAGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAG GTCTAGGTGGTACCTGATCTCTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAG CCCCGGGGGGCGACGACGGTGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGT GCCGCGGGCGGGCCCCCGGAGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGT CGGCGTGGAGCGCGGGCAGGAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGC GGTTGATCTCCTGGATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGA GAGTTCGACAGAATCAATCTCGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCC GAGTTGTCTTGGTAGGCGATCTCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCC GGCGCGTTCCACGGTGGCCGCCAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGT CCGCCCTCGTTCCAGACTCGGCTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCT GCGCGAGGTTGAGCTCCACGTGCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGT TGAGGGTGGTGGCGGTGTGCTCGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTT GATGTCCCCCAAGGCCTCCAGCCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGG GAGTTGCGCGCCGACACGGTCAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCA CCTCGCGCTCGAAGGCTATGGGGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTT CTGGCACTTCCATGATGGCTTCCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGC TCTGCGCCGGCGGCGGCGCACCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCG GCGCATGGTCTCGGTGACGGCGCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATC TGGTGCTGGGGCGGGTGGCCGTGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCG TAGGTACGCCGCCGAGGGACCTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGG CGTCTAACCAGTCGCAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGT GTCTGGCGGAGGTGCTGCTGATGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAG GAGCACCATGTCCTTGGGTCCGGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCT GGCATCGGCGCAGGTCCTTGTAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTT CTGCTTCTTCCATGTCTGCTTCGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACC CCGAACCCCCTGAGCGGTTGGAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGC TGCACCTGCGTGAGGGTGGTTTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGA TGGTGTAGGTGCAGTTGGCCATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGT GTACCTGAGTCGCGAGTAGGCGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGG TAGCCCACCAGGAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCG GGGGCCAGGTCTTCCAGCATGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCG CGGCGGTGGTGGAGGCGCGCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGT GCTCCATGGTAGGCGTGCTCTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAA CGAAAGCCGGTCAGCGGGCACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGG GCCTCGGTTCGAGCCCCGGGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTG TCGAACCCAGGTGTGCGACGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCC GGCGCCGCGTAAGAGACTAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAG GGATCCTTGCTAAGGGTTGCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACC CGCGGCTAAGGTGTTGGATTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACA CGGGGACGAGCCCCTTTTATTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCG CCCCAGCAGCAGCAACAACACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCC TCACCCACCCTCGGCGGGCCGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCG GGGGGCCGGCTGACGACCCCGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGG AGGGCGAGGGCCTGGCGCGGCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGC GCGACTCGCGCGAGGCGTACGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCG AGGAGATGCGGGACAGGAGGTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGG CTGCTGCGCGAGGAGGACTTTGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTG GCGGCCGCCGACCTGGTGACGGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGT TTCAACAACCACGTGCGCACGCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGG ACTTTGTAAGCGCGCTGGTGCAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGT GCAGCACAGCAGGGACAACGAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCG GTGGCTGCTGGACCTGATTAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCC GACAAGGTGGCGGCCATCAACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACC AGACGCCGTACGTGCCCATAGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAA GGTGCTCACCCTGAGCGACGACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTG AGCCGGCGGCGCGAGCTGAGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCC GGCAGCGGCGACAGGGAGGCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGC CGGCGGGCCCTGGAGGCCGCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGA GTACGAGCTAGAGGAGGGCGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGAC CCGAACGTGGTGGACCCGGCGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAG ACGACTGGCGACAGGTCATGGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCA GCAGCCGCAGGCCAACAGGCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACG CACGAGAAGGTGCTGGCCATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCC GGGCTGGTGTACGACGCGCTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAAC CTGGACCGGCTGGTGGGGGACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGC AACCTGGGCTCCATGGTGGCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGC AGGAAGACTACACCAACTTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGG TGTACCAGTCGGGCCCGGACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAG CCAGGCTTTCAAGAACCTGCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGT GTCCAGCCTGCTGACGCCCAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGC AGCGTGTCCCGGGACACCTACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGC AGGTGGACGAGCACACCTTCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGA GCAGCCTGGAGGCGACTCTGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAG CCTGACCTCCGAGGAGGAGCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGC GACGGGGTGACGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCC GCGCACCGGCCTTACATCAACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGT ACTTTACCAACGCCATCCTGAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGA GGTCCCGGAGACCAACGATGGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCG CAGGCGCTGGCGGAAGCGTCCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGC CGCGGCAGCAGCGGCGTGGCTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCC TGGGCGGCAGCCCCTTTCCGAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCT GCTGGGCGAGGACGAGTACCTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCC GCCTTCCCCAACAACGGGATAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAG GAGCACAGGGACGCGCCTGCGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGG CTGGTGTGGGATGACGAGGACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAAC CCGTTCGCGCACCTGCGCCCCCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGC ATGATGCAAAAATTAAATAAAACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTT CAGTATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCG GCGGCGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTA CCTGCGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACC CGGGTGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGC AATTTTTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCA ATCTGGATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGT GAACGAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAA GACCGGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACC ATGACCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGG GTCCTGGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGA CCGGGCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGG CTGCGGGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTC CAGGAGGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGG AGGCCTACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCG CCGCCGCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCG CTATGGTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCT TCGTCACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCG GCAGCAGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAG GAGCCCGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGC ACCAACACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCT

CCTGGACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGA CATGATGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCC GAGCTGCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCC AGTTCACCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCC CCCACCATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCA ACAGCATCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTA CAAGGCCTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCAT GTCCATCCTGATCTCACCCAGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTC GGAGGGGCGAGGAAGCGTTCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGG GGAGCGCACAAACGCGGCCGCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAG CAGGCGCGCAACTACAGGCCCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCG CGCGGCGGTACGCCAAGCTGAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCG GGGCCGCCGCCAAACGCGCCGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCG CCATGAGGGCCGCGCGCCGCTTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAG ACGCGCGGCCGCCGCCGCCGCCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTA CTGGGTGCGCGACTCGGTGACCGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGAT GATGTGAAAAAACAACACTGAGTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCG TCATGTCCAAGCGCAAAATCAAAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCC GAAGAAGGAAGAGCAGGATTCGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATG ATGACGATGCCGATGGGGAGGTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGA AGGGCCGGCGCGTAAAGCGCGTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTC CACCCGGACTTTCAAGCGCGTCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAAC GAGCGCTTCGGAGAGTTTGCTTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCG CTGCCGCTGGACCAGGGCAACCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGA GCAGCGCACCCTCCGAGGCGAAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGC AGCTCATGGTGCCCAAGCGGCAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTC TGCAGCCGGACATCAGGGTCCGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGG ACGTGGTCATCCCCACCGGCAACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGA GACACAGACCGATCCCGCCGCAGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCA GACGGACCCCTGGCTGCCGCCGGCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGC GCCGCCAACGCGCTCCTGCCCGAGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGG CTATACCTACCGCCCGCGAAGAGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACC ACCCGCCGCCGCCGCCGCAGACGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCG ACGGACACACCCTGGTGCTGCCCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGT TCTTGCAGATATGGCCCTCACTTGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCG CGCCGCAGGAGGGGTCTGGCCGGCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGA CGCGCCACCAGCCGACGCATGCGCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGA TCGGCGCCGTGCCCGGGATCGCCTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAA ACTTGCAAATATGGAAAAAAAAACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTG ACTATTTTGTAGAATGGAAGACATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCC TGGGACACTGGAACGATATCGGCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTG GAGCGGCATTAAAAGTATCGGGTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACG GGCCAGATGTTGAGAGACAAGTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCC TCCGGCATCAACGGGGTGGTGGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTG GACCCCCGGCCGCCGGTGGAGGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGC GAGAAGCGCCCGCGGCCCGATAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCG TATGAGGAGGCCCTGAAGCAAGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGG TGGGCCGCCACACCCCCGCCACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGC GGCACAGCCGGGCCCGCCCGCGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGC GGCCCCCGCGGGGGGGTCGCGAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTG GGGGTGCGGTCCGTGAAGCGCCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTAT GCGCCCTATGTCGCCGCCAGAGGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCAC TCCGCCCCTCAAGATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAG GACGCCTCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCC TGAGTAACAAGTTTAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCG CCTGACGCTGCGGTTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACC CTGGCCGTGGGCGACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGG ACCGGGGTCCCACTTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCC AACTCCTGCGAGTGGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGA AGATGCTGACGGTCAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGC TCCCCTTTCTGGCGAAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAA CAAAAACCTATTTATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATG AGGCAGATGCTACAGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGG TTCCTATGCAAGACCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAG CTAGAATCTCAGGTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACA TTCAGCCCAAATTGGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTAC AAGCCCGCAAAAAGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCT AATTACATCGGCTTCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAG TGCTTGCAGGTCAGGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTC CTACCAGCTCTTGCTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGG ACAGTTATGACCCAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTG TTTCCCTCTGGGTGGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAAC GGGGGCCAGGTGACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAAC AATTTCGCTATGGAGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCT GTACCTACCAGACAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTAC GATTACATGAACAAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCT GGTCGCTGGACTACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCG CTCCATGCTCCTGGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCA TCAAGAACCTCCTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACAT GGTCCTCCAGAGCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATC TGCCTCTACGCCACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAA CGACACCAACGACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCA ACGCCACCAACGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACC CGCCTCAAGACCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCT CCATTCCCTACCTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGAC TCCTCGGTCAGCTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGG TCGACGGGGAGGGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCT GGCCAACTACAACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCC TTCTTCAGGAACTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGG AGGTGGGCATCATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGA GGGACAGGCCTACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACC CAGAAAAAGTTCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGG TGCGCTCTCGGACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCG AGGTCGACCCCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTC CACCAGCCGCACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCA CCACCTAAAGAAGCAAGCCGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTC AGGGCCATCGTCAGAGACCTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTG GCTTTGTCTCCCCACACAAGCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGT GCACTGGCTGGCCTTCGCCTGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTT CGGACCAGCGGCTCAAGCAAATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGC CTCCTCGCCCGACCGCTGCGTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCC GCCTGCGGTCTCTTCTGCTGCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCG CAACCCCACCATGAACTTGCTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCC ACCCTGCGCCGCAACCAGGAGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCC ACAGCGCACAGATCAGGAGGGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAAC GATGTACACACTTTTTTTCTCAATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTT CCCACCACCACCCGCCGTTGTCGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCG CCGTGCGCCACGGGCAGGGACACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCA CCAGGCGAGGCAGCTCGGGGAAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAG GTCGGGCGCCGAGATCTTGAAGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACC GGGTTGCAGCACTGGAACACCAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAG ATCAGCTCGGCGTCCAGGTCCTCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCC CAGGAAGGGCGCGTGCCCCGGTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGC CCGGACTCGGCGTTGGGGTACAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCT TGGCGCCCTCCGAGAAGAACATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTC GTGCAGGCAGCAGCGCGCGTCGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACG ATCTTGGCCTTGGACGATTGCTCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGAT CACATGTTCCTTGTTCACCATGCTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGC GGTGCTGCCACAGCGCGCAGCCCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAG GTACCCCTGCAAAAAGCGGCCCATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGC CCGCGGTGCTCCTCGTTCAGCCAGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCA TCTTGAAGTTCACCTTCAGCTCATTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATG CCCTTCTCCCAGGCCGACACCAGCGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTC CGCCGCGCTTTCGCTTTCCGCCCCGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGC AGCCCCCGCACCACGGGGTCGTCTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTT GATGCGCACGGGCGGGTTGCTGAAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGT

CCAGAATGACCTCCGGGGAGGGGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTG GGGGCGTTCGCCAGCTCCGCGGCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGC GGCACCAGCGCGTCCTGCGAGCCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCT TCGGGGGCGCGCGGGGCGGCGGAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGG GTGGGTGGACGGCGGGCCGCGCCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGAC TGGCCATCTCCCACTGCTCCTTCTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAG AAGGAGGAGGACAGCCTAACCGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCG CCGCGGACGACGCGCCCACCGAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGA GAATGAAGTGCTGATCGAGCAGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAA GGAGAAGGAGGAGGTCGCCGCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAG ATAAGGATGAGACAGCAGTCGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACG TGGGAGACGACGTGCTGCTTAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGA GCGCTGCGAAGTGCCCCTGGACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCG CACGTGCCCCCCAAGCGCCGGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGG TCTTCGCGGTACCCGAGGTGCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCC TGCCGCGCCAACCGCACCCGCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATA TCGCCTCTCTGGAGGAAGTGCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAA CGCTCTGCACGGAGACAGCGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAA CGCGCGCCTGGCCGTACTCAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTG CCCCCCAAGGTCATGAGTGTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGG ATGCAAACTTGCAAGAGTCCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCT GGCTGGAGACCCGCGACCCCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGG TCACCGTGGAGCTCGAGTGTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGA GACCCTGCACTACACCTTCCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTC TGCAACCTGGTCTCCTACCTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCA CCCTCAAAGGGGAGGCGCGCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTG GCAGACGGCCATGGGGGTCTGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCT CCTCAAGCGCACCCTCAGGGACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCG GACATCATCTTTCCCGAGCGCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGA GCATGCTGCAGAACTTCAGGACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCG CTGCCCAGCGACTTCGTGCCCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACC TCTTCCAGCTGGCCAACTACCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCT GCTCGAGTGCCACTGCCGCTGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGC TCAGCGAGAGTCAGATTATCGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGC TCCAGGGCTGAAACTCACTCCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACT ACCACGCCCACGAGATCAGGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTG CGTCATCACCCAGGGGCACATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTG CTGAAAAAGGGTCGGGGGGTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCG CCGCCGCCCCAGCAGCGGGACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCC GCCGCCGCAGCCATACATGCTTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGT TTCGGACGAGGAGCAGGAGGAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAG CTTCAGAGGCCGAAGAGGTGGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCC CCTGAAATCCTCCGAACCCAGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCC CGCAGACCCAACCGTAGATGGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCG CCACCGCAGCAGCAGCAGCAGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATA GTCGCCTGCTTGCAAGACTGCGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGG GGTCGCCTTTCCCCGCAATGTCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACC CAGAGGCGGCAGCGGCAGCCACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACA GCGGCAGCAGCGGCCAGGAGACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCG CCCAACGAACCCCTCTCGACCCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCA ACAGAGCAGAGGCCAGGAGCAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAG CTGTCTGTATCACAAAAGCGAAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGC AAATACTGCGCGCTCACTCTTAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTA CGTCATCGCCGGCCGCCGCCCAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATG TGGAGCTACCAGCCGCAGATGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAAC TACATGAGCGCGGGACCCCACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATA CTGCTGGAACAGGCGGCCATCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCG CCCTCGTGTACCAGGAAACCCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGT CCAGATGACTAACTCAGGGGCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCA GGTATAAGACACCTGATGATCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGC TCGGTCTCCGTCCGGACGGAACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAG GCGTACCTGACTCTGCAGACCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGT GGAGGAGTTCGTGCCCTCGGTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGT TCATTCCGAACTTTGACGCGGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGC AGAGCAGCTTCGCCTGAGACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGT GAGTTCTGCTACTTTCAGCTACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCA CCCAGGGCGAGGTTACCTGTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAG CGGGGTCCCTGTGTCCTAACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTG TCATCTCTGTGCTGAGTTTAATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTG AACGCCACCGTCTTCACCCACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGG CCAAGAAGTACCTCACCTGGTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGA CGGAGTCTCCCTGAAAGACCAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAA CTCTTCCCTCCCTACCTGCCGGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCT GATCGTAAACCAGAGCTTTCCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGG AAACTCCCCGGGGACCAGGGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCG GGTTGCTGGCTCTTTTAATCAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCA ACCTCCAATAACTCTACCCTTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCT TACTCTGTTGATTTTTTTCCTTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACA CATCTATATCTACTGCTGGTTGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCC TATCGATCCTAGGCCTGCTGGCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGA GCCCGCTTGCAATGTAACTTTCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACC AATCATGAGAGGCTGCGCATCGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTA CGCCCGGAGACCCCTCTAACTACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTAC ACTTTCCCTTTTTATGAGTTATGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCC CTCTCCCCAGGCGTGTGTGGAAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCG CTCTAATCTGCACGGTGCTATACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAAT GCCTTGATCGCTAACACCGGCTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACC ACCCTCCTTGCGATTGCCCATGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGG TGGGCCCCGCCGGCAATTCCACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGC TCTAACCGAATCAGTATCAAGCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGC AAATGATGGATGCTGGGTACTATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAA GGACTACATGCTGCATGTAGTCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCA CCACCACTACTACTACTACTACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAA AGCACCATGATTAGCACAAAGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCT CAGAAACCACCGAGCTTTGCTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGA GAATGAGGATGTCCAGCAGAGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAG CAGATCGGTGATTCAATAATTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTC CACATCACGGGTACCAAAGACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGT CTCTTCCGCGCTGATGTTACTGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCT CTCAGGGCCAACCACTGATGCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGC TGCTGACACTAACCGCTTTACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAAT GTCACAGCTGTGGCAGGAGAAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTG GCTCAGGTAGCTACTTAACTATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAA TGCAATGCCAGCCTGTTCACCCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGT ACCCTTTGGTGGGCAAGGAAAGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACC CAAGCTTCTCCCACCACCACCACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCA GCAGCAGCAGATTATTGACTTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCT GTGCCCGAAACCACTCAGATCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCG ATCAGATGCCGACCAACATCACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACC AGTGGATGCGGCCGAGGTCTCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCC ATAGGCATGATGGCGCTCTGCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAG ACCCCCCATCTATAGACCCATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCC TGAAAAACCTACTTTTTTCTTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTT CCTTCTCCCACCTTTTCTGGGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTC ACCCTTCACTGTCTACCTGCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAAT CATCGCCTTCATCCAGTGCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGT ACCGAGACAGGAACATTGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTC TGATCCTCTGCATCCTGCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACAT GCCTCCTGCCGCTTCACCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCG AAGCTTGGCTGTATGGGGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACC CCTACTTTGATTTGGGATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATA ATTCCACTGCGACAAGTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAAT CAGCTACTTTAACCTAACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTAC CGAGCAGCGTCTCCTAGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCG AGATCTCGTTAACCTGCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACC

TACGAGAAGACCGGCAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGC TCATGGTGGGTGAGAATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTC CCCCTGTCGGGGTCCAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTC CCCTTTAACTAATCAAACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCT CTGTCCAGTTTATTCAGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCG GCAAACTTCCTCCACACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTT CATGTTGTTGCAGATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGAC ACGGAAAGCGGCCCTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGA AAGTCCCCCCGGGGTCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCC TGAAAATGGGAAGTGGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGC TAGCCCTCCCCTCAAAAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGC ACCTCAGGCGCCCTCACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGC AATCAGAGGCCCCCCTGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGT GTCTGAAGGCAAACTGGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACA GTCAGTGCCACACCACCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTT ACACCACCAATGGAAAACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGC ACTGACTGTAGTTACTGGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGT GCCCTCAACTATGACACATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAA ATGGTCAACTTATCCTTGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGA CAGGGACCCCTGTTTGTTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTT CACATCTGGAAATACCAAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGAC ACTGCTATAGCAATCAATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAA AAACTAAACTTGGATTAGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGG CCTAAGCTTTGACAACACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGG ACCACACCAGACCCATCCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTT GACTAAATGCGGCAGTCAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCA TCAGTGGCACAGTAACTAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAA TTCTTCCCTTGACCCTCAATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACC AACGCAGTGGGATTTATGCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGC AACATTGTAAGTCAGGTTTACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCA ATGGAACTAATGAAACAGGAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAA TGGAAGTAATTACATTAATGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAAT AAAAAGCATGACGCTGTTGATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATT CAAGTCATTCTTCCATCTTAGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCAT TCTAGCTTATAGATCAGACAGTGATAATTAACCACCACCACCACCATACCTTTTGATTCAGGAAATCA TGATCATCACAGGATCCTAGTCTTCAGGCCGCCCCCTCCCTCCCAAGACACAGAATACACAGTCCTCT CCCCCCGACTGGCTTTAAATAACACCATCTGGTTGGTCACAGACATGTTCTTAGGGGTTATATTCCAC ACGGTCTCCTGCCGCGCCAGGCGCTCGTCGGTGATGTTGATAAACTCTCCCGGCAGCTCGCTCAAGTT CACGTCGCTGTCCAGCGGCTGAACCTCCGGCTGACGCGATAACTGTGCGACCGGCTGCTGGACGAAC GGAGGCCGCGCCTACAAGGGGGTAGAGTCATAATCCTCGGTCAGGATAGGGCGGTGATGCAGCAGC AGCGAGCGAAACATCTGCTGCCGCCGCCGCTCCGTCCGGCAGGAAAACAACACGCCGGTGGTCTCCT CCGCGATAATCCGCACCGCCCGCAGCATCAGCTTCCTCGTTCTCCGCGCGCAGCACCTCACCCTTATC TCGCTCAAATCGGCGCAGTAGGTACAGCACAGCACCACGATGTTATTCATGATCCCACAGTGCAGGG CGCTGTATCCAAAGCTCATGCCGGGAACCACCGCCCCCACGTGGCCATCGTACCACAAGCGCACGTA AATCAAGTGTCGACCCCTCATGAACGCGCTGGACACAAACATTACTTCCTTGGGCATGTTGTAATTCA CCACCTCCCGGTACCAGATAAACCTCTGGTTGAACAGGGCACCTTCCACCACCATCCTGAACCAAGA GGCCAGAACCTGCCCACCGGCTATGCACTGCAGGGAACCCGGGTTGGAACAATGACAATGCAGACT CCAAGGCTCGTAACCGTGGATCATCCGGCTGCTGAAGGCATCGATGTTGGCACAACACAGACACACG TGCATGCACTTTCTCATGATTAGCAGCTCTTCCCTCGTCAGGATCATATCCCAAGGAATAACCCATTC TTGAATCAACGTAAAACCCACACAGCAGGGAAGGCCTCGCACATAACTCACGTTGTGCATGGTCAGC GTGTTGCATTCCGGAAACAGCGGATGATCCTCCAGTATCGAGGCGCGGGTCTCCTTCTCACAGGGAG GTAAAGGGTCCCTGCTGTACGGACTGCGCCGGGACGACCGAGATCGTGTTGAGCGTAGTGTCATGGA AAAGGGAACGCCGGACGTGGTCATACTTCTTGAAGCAGAACCAGGTTCGCGCGTGGCAGGCCTCCTT GCGTCTGCGGTCTCGCCGTCTAGCTCGCTCCGTGTGATAGTTGTAGTACAGCCACTCCCGCAGAGCGT CGAGGCGCACCCTGGCTTCCGGATCTATGTAGACTCCGTCTTGCACCGCGGCCCTGATAATATCCACC ACCGTAGAATAAGCAACACCCAGCCAAGCAATACACTCGCTCTGCGAGCGGCAGACAGGAGGAGCG GGCAGAGATGGGAGAACCATGATAAAAAACTTTTTTTAAAGAATATTTTCCAATTCTTCGAAAGTAA GATCTATCAAGTGGCAGCGCTCCCCTCCACTGGCGCGGTCAAACTCTACGGCCAAAGCACAGACAAC GGCATTTCTAAGATGTTCCTTAATGGCGTCCAAAAGACACACCGCTCTCAAGTTGCAGTAAACTATG AATGAAAACCCATCCGGCTGATTTTCCAATATAGACGCGCCGGCAGCGTCCACCAAACCCAGATAAT TTTCTTCTCTCCAGCGGTTTACGATCTGTCTAAGCAAATCCCTTATATCAAGTCCGACCATGCCAAAA ATCTGCTCAAGAGCGCCCTCCACCTTCATGTACAAGCAGCGCATCATGATTGCAAAAATTCAGGTTCT TCAGAGACCTGTATAAGATTCAAAATGGGAACATTAACAAAAATTCCTCTGTCGCGCAGATCCCTTC GCAGGGCAAGCTGAACATAATCAGACAGGTCCGAACGGACCAGTGAGGCCAAATCCCCACCAGGAA CCAGATCCAGAGACCCTATACTGATTATGACGCGCATACTCGGGGCTATGCTGACCAGCGTAGCGCC GATGTAGGCGTGCTGCATGGGCGGCGAGATAAAATGCAAAGTGCTGGTTAAAAAATCAGGCAAAGC CTCGCGCAAAAAAGCTAACACATCATAATCATGCTCATGCAGGTAGTTGCAGGTAAGCTCAGGAACC AAAACGGAATAACACACGATTTTCCTCTCAAACATGACTTCGCGGATACTGCGTAAAACAAAAAATT ATAAATAAAAAATTAATTAAATAACTTAAACATTGGAAGCCTGTCTCACAACAGGAAAAACCACTTT AATCAACATAAGACGGGCCACGGGCATGCCGGCATAGCCGTAAAAAAATTGGTCCCCGTGATTAAC AAGTACCACAGACAGCTCCCCGGTCATGTCGGGGGTCATCATGTGAGACTCTGTATACACGTCTGGA TTGTGAACATCAGACAAACAAAGAAATCGAGCCACGTAGCCCGGAGGTATAATCACCCGCAGGCGG AGGTACAGCAAAACGACCCCCATAGGAGGAATCACAAAATTAGTAGGAGAAAAAAATACATAAACA CCAGAAAAACCCTGTTGCTGAGGCAAAATAGCGCCCTCCCGATCCAAAACAACATAAAGCGCTTCCA CAGGAGCAGCCATAACAAAGACCCGAGTCTTACCAGTAAAAGAAAAAAGATCTCTCAACGCAGCAC CAGCACCAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGA CGTAAACGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAA GCCAAAAAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTCCCCCG GTCAAACAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGC CCGCCGGCCCGCCCCCGGACCCGCCTCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGCTTCAAT CCAAAATAAGGTATATTATTGATGATG Polynucleotide sequence encoding ChAd155/RSV SEQ ID NO: 11 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCAGATATCGCCACCA TGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGCTTCGCC AGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGAGCAAGGGCTACCTG AGCGCCCTGAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAAC AAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAGGAACTGGACAAGTACAAGAACGCC GTGACCGAGCTGCAGCTGCTGATGCAGAGCACCCCCGCCACCAACAACCGGGCCAGACGGGAGCTG CCCCGGTTCATGAACTACACCCTGAACAACGCCAAAAAGACCAACGTGACCCTGAGCAAGAAGCGG AAGCGGCGGTTCCTGGGCTTTCTGCTGGGCGTGGGCAGCGCCATTGCCAGCGGCGTGGCCGTGTCTA AGGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCG TGGTGTCCCTGAGCAACGGCGTGAGCGTGCTGACCAGCAAGGTGCTGGATCTGAAGAACTACATCGA CAAGCAGCTGCTGCCCATCGTGAACAAGCAGAGCTGCAGCATCAGCAACATCGAGACAGTGATCGA GTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGGGAGTTCAGCGTGAACGCCGGCGTGAC CACCCCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATC ACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACTCCATC ATGTCCATCATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCCCTGTACGGCGTGATCGACA CCCCCTGCTGGAAGCTGCACACCAGCCCCCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTG CCTGACCCGGACCGACAGAGGCTGGTACTGCGACAACGCCGGCAGCGTGTCATTCTTTCCACAGGCC GAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAACAGCCTGACCCTGCCCTCCG AAGTGAACCTGTGCAACGTGGACATCTTCAACCCCAAGTACGACTGCAAGATCATGACCTCCAAGAC CGACGTGTCCAGCTCCGTGATCACCTCCCTGGGCGCCATCGTGTCCTGCTACGGCAAGACCAAGTGC ACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAAC AAGGGGGTGGACACCGTGTCCGTGGGCAACACCCTGTACTACGTGAACAAACAGGAAGGCAAGAGC CTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCCCTGGTGTTCCCCAGCGACGAGTTCG ACGCCAGCATCAGCCAGGTGAACGAGAAGATCAACCAGAGCCTGGCCTTCATCCGGAAGTCCGACG AGCTGCTGCACAATGTGAATGCCGGCAAGTCCACCACCAACCGGAAGCGGAGAGCCCCTGTGAAGC

AGACCCTGAACTTCGACCTGCTGAAGCTGGCCGGCGACGTGGAGAGCAATCCCGGCCCTATGGCCCT GAGCAAAGTGAAACTGAACGATACACTGAACAAGGACCAGCTGCTGTCCAGCAGCAAGTACACCAT CCAGCGGAGCACCGGCGACAGCATCGATACCCCCAACTACGACGTGCAGAAGCACATCAACAAGCT GTGCGGCATGCTGCTGATCACAGAGGACGCCAACCACAAGTTCACCGGCCTGATCGGCATGCTGTAC GCCATGAGCCGGCTGGGCCGGGAGGACACCATCAAGATCCTGCGGGACGCCGGCTACCACGTGAAG GCCAATGGCGTGGACGTGACCACACACCGGCAGGACATCAACGGCAAAGAAATGAAGTTCGAGGTG CTGACCCTGGCCAGCCTGACCACCGAGATCCAGATCAATATCGAGATCGAGAGCCGGAAGTCCTACA AGAAAATGCTGAAAGAAATGGGCGAGGTGGCCCCCGAGTACAGACACGACAGCCCCGACTGCGGCA TGATCATCCTGTGTATCGCCGCCCTGGTGATCACAAAGCTGGCCGCTGGCGACAGATCTGGCCTGAC AGCCGTGATCAGACGGGCCAACAATGTGCTGAAGAACGAGATGAAGCGGTACAAGGGCCTGCTGCC CAAGGACATTGCCAACAGCTTCTACGAGGTGTTCGAGAAGTACCCCCACTTCATCGACGTGTTCGTG CACTTCGGCATTGCCCAGAGCAGCACCAGAGGCGGCTCCAGAGTGGAGGGCATCTTCGCCGGCCTGT TCATGAACGCCTACGGCGCTGGCCAGGTGATGCTGAGATGGGGCGTGCTGGCCAAGAGCGTGAAGA ACATCATGCTGGGCCACGCCAGCGTGCAGGCCGAGATGGAACAGGTGGTGGAGGTGTACGAGTACG CCCAGAAGCTGGGCGGAGAGGCCGGCTTCTACCACATCCTGAACAACCCTAAGGCCTCCCTGCTGTC CCTGACCCAGTTCCCCCACTTCTCCAGCGTGGTGCTGGGAAATGCCGCCGGACTGGGCATCATGGGC GAGTACCGGGGCACCCCCAGAAACCAGGACCTGTACGACGCCGCCAAGGCCTACGCCGAGCAGCTG AAAGAAAACGGCGTGATCAACTACAGCGTGCTGGACCTGACCGCTGAGGAACTGGAAGCCATCAAG CACCAGCTGAACCCCAAGGACAACGACGTGGAGCTGGGAGGCGGAGGATCTGGCGGCGGAGGCATG AGCAGACGGAACCCCTGCAAGTTCGAGATCCGGGGCCACTGCCTGAACGGCAAGCGGTGCCACTTCA GCCACAACTACTTCGAGTGGCCCCCTCATGCTCTGCTGGTGCGGCAGAACTTCATGCTGAACCGGATC CTGAAGTCCATGGACAAGAGCATCGACACCCTGAGCGAGATCAGCGGAGCCGCCGAGCTGGACAGA ACCGAGGAATATGCCCTGGGCGTGGTGGGAGTGCTGGAAAGCTACATCGGCTCCATCAACAACATCA CAAAGCAGAGCGCCTGCGTGGCCATGAGCAAGCTGCTGACAGAGCTGAACAGCGACGACATCAAGA AGCTGAGGGACAACGAGGAACTGAACAGCCCCAAGATCCGGGTGTACAACACCGTGATCAGCTACA TTGAGAGCAACCGCAAGAACAACAAGCAGACCATCCATCTGCTGAAGCGGCTGCCCGCCGACGTGCT GAAAAAGACCATCAAGAACACCCTGGACATCCACAAGTCCATCACCATCAACAATCCCAAAGAAAG CACCGTGTCTGACACCAACGATCACGCCAAGAACAACGACACCACCTGATGAGCGGCCGCGATCTGC TGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGC CACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTA TTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTG GGGATGCGGTGGGCTCTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTG GTCATGAAAATATATAAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCA TGAGCGGGAGCAGCAGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTT GACGACGCGGATGCCCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCG ACCCGTCCTGCCCGCAAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCC ACCGCCGCCGCCGCCGCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCC TGGGACCACTGGCGACAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGAC CGCCCTGCTGGCGCAGTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCC TGCGCCAGCAGGTCTCCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAA ATAAAACCAGACTCTGTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTT CCGCGCGCGATAGGCCCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACG TGGTAGAGGTGGCTCTGGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACC ACTGCAGAGCTTCATGCTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATG GTGCCTAAAAATGTCCTTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACA AAACGGTTAAGTTGGGAAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGAT TGGCGATGTTTCCGCCCAGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCG GTGCACTTGGGGAATTTGTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGT GGCCTCCCAGATTTTCCATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGC AAAGATATTTCTGGGGTCGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTA CAAAGCGCGGGCGGAGGGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCC CTCGCAGATCTGCATTTCCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATG AAGAAAACGGTTTCCGGAGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATT TTCCACAACCGGTGGGCCCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCA GCTGCCGTCGTCCCGGAGGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCG ACCAGATCCGCCAGAAGGCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCA GCGGCTTGAGGCCGTCCGCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCA GAGCTCGGTGACGTGCTCTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACT TTCGCTGTAGGGCACCAAGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGG GTCCTCGTCAGGGTGGTCTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGC GCTTGAGGCTGGTTCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCAT TTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGT GGCGCCGCACGAGGGGCAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTC GGGGGAGTAGGCGTCCGCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCG GGGCGCGCCGGGTCAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCAT GAGGTGGTGTCCCCGCTCGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTT TTCTCCAGGGGGGTCCCTCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCG TCCAGGCCAGGACGAAGGAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTT CTCCAAGGTGTGAAGACACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAG GCCACGTGACCGGGGGTTCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCT CTTCCGCATCGCTGTCTGCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGAC CTCCGCGCTGAGGTTGTCAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATA CCTTTGAGGGTACCCGCGTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAA CGACCCGTAGAGGGCGTTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCG GCGCGCTCCTTGGCCGCGATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGA CGGTGGTGCGCTCGTCGGGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCAC GCTGGTGGCGACCTCGCCGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAG AAGGGGGGCAGGGGGTCGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGG CGCAGGCGCGCGTCGAAGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGG CGGCGAGCGCGCGCTCGTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGG CGTACATGCCGCAGATGTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGC AGCGGCCGCCGCGGATGCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGG GGCCCAGGTTGGTGCGGGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGT TGGAAGAGATGGTGGGGCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCA CGAAGGAGGCGTAGGAGTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGC AGTAGTCGAGGGTCTCGCGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTG AGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAG AGCCTAGCATGTAGAACTGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTA GGCCTGCGCGGCCTTGCGGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGG TACTGGTGCTTGAAGTCGGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCT TGGAGCGGGGGTTGGGCAGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGA AGTTGCGGGTGATGCGGAAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCAC GATCTCGTCGAAGCCGTTGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTT ACGGTGGGCAGCTTCTTTAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCA GGGCCCAGTCCGCGAGGTGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGG TCTGCAGGCGGTCTCTGAAGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTA GAAGGTGAGGGGGTCTTGCTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGT GACCAGGCGCTCGTCGCCCCCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCC CCCATCCAAGTGTAGGTCTCTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGA TCGGGAAGAACTGGATCTCCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTC CCGTCGCCGGGCCGAACACTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACG GGCTGTACCTCATGCACGAGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCC CCCCGCCTGGCTCGCGGCATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCT CGAGGGGTGTTACGGTGGAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCG GCGGTCGGAGTTTGATGACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGG CGGCAGGTCAGCCGGGAGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCT AGGTGGTACCTGATCTCTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCC GGGGGGCGACGACGGTGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCG CGGGCGGGCCCCCGGAGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGC GTGGAGCGCGGGCAGGAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTT GATCTCCTGGATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGT TCGACAGAATCAATCTCGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTT GTCTTGGTAGGCGATCTCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGC GTTCCACGGTGGCCGCCAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCC CTCGTTCCAGACTCGGCTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCG AGGTTGAGCTCCACGTGCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGG GTGGTGGCGGTGTGCTCGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGT CCCCCAAGGCCTCCAGCCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTT GCGCGCCGACACGGTCAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCG CGCTCGAAGGCTATGGGGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGC ACTTCCATGATGGCTTCCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGC GCCGGCGGCGGCGCACCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCA TGGTCTCGGTGACGGCGCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTG CTGGGGCGGGTGGCCGTGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGT ACGCCGCCGAGGGACCTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTA

ACCAGTCGCAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGG CGGAGGTGCTGCTGATGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCA CCATGTCCTTGGGTCCGGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCAT CGGCGCAGGTCCTTGTAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCT TCTTCCATGTCTGCTTCGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAA CCCCCTGAGCGGTTGGAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACC TGCGTGAGGGTGGTTTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGT AGGTGCAGTTGGCCATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCT GAGTCGCGAGTAGGCGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCC CACCAGGAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGC CAGGTCTTCCAGCATGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCG GTGGTGGAGGCGCGCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCC ATGGTAGGCGTGCTCTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAA GCCGGTCAGCGGGCACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTC GGTTCGAGCCCCGGGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAA CCCAGGTGTGCGACGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGC CGCGTAAGAGACTAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATC CTTGCTAAGGGTTGCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGG CTAAGGTGTTGGATTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGG ACGAGCCCCTTTTATTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCA GCAGCAGCAACAACACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACC CACCCTCGGCGGGCCGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGG CCGGCTGACGACCCCGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGC GAGGGCCTGGCGCGGCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGAC TCGCGCGAGGCGTACGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAG ATGCGGGACAGGAGGTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTG CGCGAGGAGGACTTTGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCC GCCGACCTGGTGACGGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAAC AACCACGTGCGCACGCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTG TAAGCGCGCTGGTGCAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCA CAGCAGGGACAACGAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCT GCTGGACCTGATTAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAG GTGGCGGCCATCAACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGC CGTACGTGCCCATAGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCT CACCCTGAGCGACGACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCG GCGGCGCGAGCTGAGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAG CGGCGACAGGGAGGCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCG GGCCCTGGAGGCCGCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACG AGCTAGAGGAGGGCGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAA CGTGGTGGACCCGGCGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGAC TGGCGACAGGTCATGGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGC CGCAGGCCAACAGGCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGA GAAGGTGCTGGCCATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCT GGTGTACGACGCGCTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGA CCGGCTGGTGGGGGACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCT GGGCTCCATGGTGGCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGA AGACTACACCAACTTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTAC CAGTCGGGCCCGGACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGG CTTTCAAGAACCTGCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCA GCCTGCTGACGCCCAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGT GTCCCGGGACACCTACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTG GACGAGCACACCTTCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGC CTGGAGGCGACTCTGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGA CCTCCGAGGAGGAGCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGG GGTGACGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCA CCGGCCTTACATCAACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTT ACCAACGCCATCCTGAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCC CGGAGACCAACGATGGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGC GCTGGCGGAAGCGTCCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGG CAGCAGCGGCGTGGCTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGC GGCAGCCCCTTTCCGAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGG GCGAGGACGAGTACCTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTT CCCCAACAACGGGATAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCA CAGGGACGCGCCTGCGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGT GTGGGATGACGAGGACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTT CGCGCACCTGCGCCCCCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGAT GCAAAAATTAAATAAAACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGT ATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGG CGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTG CGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGG TGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTT TTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTG GATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAAC GAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACC GGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGA CCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCT GGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGG GCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCG GGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGA GGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCC TACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCC GCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATG GTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTC ACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGC AGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCC CGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAA CACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGG ACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGA TGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCT GCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCA CCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACC ATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCA TCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGC CTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCAT CCTGATCTCACCCAGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGG GCGAGGAAGCGTTCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGC ACAAACGCGGCCGCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGC GCAACTACAGGCCCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCG GTACGCCAAGCTGAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGC CGCCAAACGCGCCGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAG GGCCGCGCGCCGCTTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCG GCCGCCGCCGCCGCCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGC GCGACTCGGTGACCGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAA AAAACAACACTGAGTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCC AAGCGCAAAATCAAAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAG GAAGAGCAGGATTCGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGA TGCCGATGGGGAGGTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCG GCGCGTAAAGCGCGTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGG ACTTTCAAGCGCGTCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCT TCGGAGAGTTTGCTTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCT GGACCAGGGCAACCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGC ACCCTCCGAGGCGAAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCAT GGTGCCCAAGCGGCAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCC GGACATCAGGGTCCGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTC ATCCCCACCGGCAACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGA CCGATCCCGCCGCAGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCC CTGGCTGCCGCCGGCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAAC GCGCTCCTGCCCGAGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTA CCGCCCGCGAAGAGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGC CGCCGCCGCAGACGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACAC ACCCTGGTGCTGCCCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGA TATGGCCCTCACTTGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGG AGGGGTCTGGCCGGCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACC AGCCGACGCATGCGCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCG TGCCCGGGATCGCCTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAA TATGGAAAAAAAAACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGT

AGAATGGAAGACATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACT GGAACGATATCGGCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCAT TAAAAGTATCGGGTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATG TTGAGAGACAAGTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATC AACGGGGTGGTGGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGG CCGCCGGTGGAGGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGC CCGCGGCCCGATAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAG GCCCTGAAGCAAGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCC ACACCCCCGCCACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCC GGGCCCGCCCGCGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGC GGGGGGGTCGCGAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGG TCCGTGAAGCGCCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATG TCGCCGCCAGAGGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTC AAGATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGG AGTACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAA GTTTAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTG CGGTTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGG GCGACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCC CACTTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCG AGTGGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGAC GGTCAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTG GCGAAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTA TTTATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGC TACAGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCA AGACCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCT CAGGTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCA AATTGGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGC AAAAAGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATC GGCTTCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAG GTCAGGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCT CTTGCTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATG ACCCAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTG GGTGGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAG GTGACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTA TGGAGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACC AGACAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATG AACAAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGG ACTACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCT CCTGGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAAC CTCCTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCA GAGCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTAC GCCACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCA ACGACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACC AACGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAA GACCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCT ACCTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTC AGCTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGG AGGGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTA CAACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGG AACTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGC ATCATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGG CCTACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAA GTTCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCT CGGACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGA CCCCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGC CGCACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTA AAGAAGCAAGCCGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCC ATCGTCAGAGACCTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGT CTCCCCACACAAGCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGG CTGGCCTTCGCCTGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCA GCGGCTCAAGCAAATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCG CCCGACCGCTGCGTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCG GTCTCTTCTGCTGCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCC ACCATGAACTTGCTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGC GCCGCAACCAGGAGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGC ACAGATCAGGAGGGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACA CACTTTTTTTCTCAATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCAC CACCCGCCGTTGTCGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGC CACGGGCAGGGACACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCG AGGCAGCTCGGGGAAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGC GCCGAGATCTTGAAGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGC AGCACTGGAACACCAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTC GGCGTCCAGGTCCTCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAG GGCGCGTGCCCCGGTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACT CGGCGTTGGGGTACAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCC CTCCGAGAAGAACATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGG CAGCAGCGCGCGTCGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGC CTTGGACGATTGCTCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTT CCTTGTTCACCATGCTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGC CACAGCGCGCAGCCCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCT GCAAAAAGCGGCCCATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTG CTCCTCGTTCAGCCAGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGT TCACCTTCAGCTCATTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCC AGGCCGACACCAGCGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCT TTCGCTTTCCGCCCCGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCG CACCACGGGGTCGTCTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCA CGGGCGGGTTGCTGAAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATG ACCTCCGGGGAGGGGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTT CGCCAGCTCCGCGGCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAG CGCGTCCTGCGAGCCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGC GCGCGGGGCGGCGGAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGG ACGGCGGGCCGCGCCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCT CCCACTGCTCCTTCTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGA GGACAGCCTAACCGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGAC GACGCGCCCACCGAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAG TGCTGATCGAGCAGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGG AGGAGGTCGCCGCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGAT GAGACAGCAGTCGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGAC GACGTGCTGCTTAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCG AAGTGCCCCTGGACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCC CCCCAAGCGCCGGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCG GTACCCGAGGTGCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGC CAACCGCACCCGCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCT CTGGAGGAAGTGCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTG CACGGAGACAGCGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGC CTGGCCGTACTCAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCA AGGTCATGAGTGTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAA CTTGCAAGAGTCCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGA GACCCGCGACCCCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGT GGAGCTCGAGTGTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTG CACTACACCTTCCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACC TGGTCTCCTACCTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAA AGGGGAGGCGCGCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACG GCCATGGGGGTCTGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAG CGCACCCTCAGGGACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCA TCTTTCCCGAGCGCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCT GCAGAACTTCAGGACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCA GCGACTTCGTGCCCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCA GCTGGCCAACTACCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAG TGCCACTGCCGCTGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGA GAGTCAGATTATCGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGG CTGAAACTCACTCCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGC CCACGAGATCAGGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATC ACCCAGGGGCACATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAA AGGGTCGGGGGGTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCC

CCAGCAGCGGGACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGC AGCCATACATGCTTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACG AGGAGCAGGAGGAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAG GCCGAAGAGGTGGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAAT CCTCCGAACCCAGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACC CAACCGTAGATGGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCA GCAGCAGCAGCAGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTG CTTGCAAGACTGCGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCT TTCCCCGCAATGTCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCG GCAGCGGCAGCCACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGC AGCGGCCAGGAGACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGA ACCCCTCTCGACCCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCA GAGGCCAGGAGCAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTA TCACAAAAGCGAAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTG CGCGCTCACTCTTAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCG CCGGCCGCCGCCCAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTA CCAGCCGCAGATGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAG CGCGGGACCCCACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGA ACAGGCGGCCATCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTG TACCAGGAAACCCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGA CTAACTCAGGGGCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAG ACACCTGATGATCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTC CGTCCGGACGGAACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCT GACTCTGCAGACCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAG TTCGTGCCCTCGGTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCC GAACTTTGACGCGGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCA GCTTCGCCTGAGACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCT GCTACTTTCAGCTACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGG CGAGGTTACCTGTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTC CCTGTGTCCTAACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCT GTGCTGAGTTTAATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCA CCGTCTTCACCCACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAA GTACCTCACCTGGTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCT CCCTGAAAGACCAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCT CCCTACCTGCCGGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAA ACCAGAGCTTTCCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCC CGGGGACCAGGGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTG GCTCTTTTAATCAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAA TAACTCTACCCTTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTT GATTTTTTTCCTTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATAT CTACTGCTGGTTGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCC TAGGCCTGCTGGCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTG CAATGTAACTTTCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAG AGGCTGCGCATCGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAG ACCCCTCTAACTACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCT TTTTATGAGTTATGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCA GGCGTGTGTGGAAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCT GCACGGTGCTATACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATC GCTAACACCGGCTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTT GCGATTGCCCATGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCG CCGGCAATTCCACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGA ATCAGTATCAAGCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGG ATGCTGGGTACTATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACAT GCTGCATGTAGTCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTA CTACTACTACTACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATG ATTAGCACAAAGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCA CCGAGCTTTGCTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGA TGTCCAGCAGAGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGT GATTCAATAATTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACG GGTACCAAAGACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCG CTGATGTTACTGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCC AACCACTGATGCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACAC TAACCGCTTTACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCT GTGGCAGGAGAAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTA GCTACTTAACTATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCC AGCCTGTTCACCCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGG TGGGCAAGGAAAGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCT CCCACCACCACCACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGC AGATTATTGACTTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGA AACCACTCAGATCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATG CCGACCAACATCACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATG CGGCCGAGGTCTCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCAT GATGGCGCTCTGCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCA TCTATAGACCCATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAA CCTACTTTTTTCTTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCC CACCTTTTCTGGGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTC ACTGTCTACCTGCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGC CTTCATCCAGTGCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAG ACAGGAACATTGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCC TCTGCATCCTGCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCC TGCCGCTTCACCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTT GGCTGTATGGGGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACT TTGATTTGGGATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCA CTGCGACAAGTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTA CTTTAACCTAACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCA GCGTCTCCTAGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCT CGTTAACCTGCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAG AAGACCGGCAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGG TGGGTGAGAATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTG TCGGGGTCCAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTA ACTAATCAAACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCA GTTTATTCAGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAAC TTCCTCCACACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTG TTGCAGATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAA GCGGCCCTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCC CCGGGGTCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATG GGAAGTGGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTC CCCTCAAAAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGG CGCCCTCACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAG GCCCCCCTGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAG GCAAACTGGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGC CACACCACCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACC AATGGAAAACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTG TAGTTACTGGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAA CTATGACACATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCA ACTTATCCTTGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGAC CCCTGTTTGTTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCT GGAAATACCAAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTA TAGCAATCAATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAA ACTTGGATTAGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGC TTTGACAACACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACAC CAGACCCATCCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAA TGCGGCAGTCAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGG CACAGTAACTAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCC TTGACCCTCAATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGT GGGATTTATGCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTA AGTCAGGTTTACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTA ATGAAACAGGAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAA TTACATTAATGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCAT GACGCTGTTGATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTC TTCCATCTTAGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTAT AACTAGTGGAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTG GTGCTGCAGCAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCA GTGGTCTCCTCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGC GCACCCTGATCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCC ACAGTGCAAGGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCAC

AAGCGCAGGTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCA TGTTGTAATTCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATC CTAAACCAGCTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGA CAGTGGAGAGCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAAC ACAGGCACACGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGG AACAACCCATTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTG TGCATTGTCAAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGT CTCAAAAGGAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGT AGTGTCATGCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGC ACCAGCACCAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGT GACGTAAACGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGA AAGCCAAAAAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCC CAGTCAAACAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCC GCCCGCCGGCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATC ATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGATG Polynucleotide sequence encoding the CASI promoter SEQ ID NO: 12 GGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCA TTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTCGAGGTGAGCCCCACGTTCTGCT TCACTCTCCCCATCTCCCCCCCCTCCCCACCCCCAATTTTGTATTTATTTATTTTTTAATTATTTTGTGC AGCGATGGGGGCGGGGGGGGGGGGGGGCGCGCGCCAGGCGGGGCGGGGCGGGGCGAGGGGCGGGG CGGGGCGAGGCGGAGAGGTGCGGCGGCAGCCAATCAGAGCGGCGCGCTCCGAAAGTTTCCTTTTAT GGCGAGGCGGCGGCGGCGGCGGCCCTATAAAAAGCGAAGCGCTCCCTATCAGTGATAGAGATCTCC CTATCAGTGATAGAGATCGTCGACGAGCTCGCGGCGGGCGGGAGTCGCTGCGCGCTGCCTTCGCCCC GTGCCCCGCTCCGCCGCCGCCTCGCGCCGCCCGCCCCGGCTCTGACTGACCGCGTTACTAAAACAGG TAAGTCCGGCCTCCGCGCCGGGTTTTGGCGCCTCCCGCGGGCGCCCCCCTCCTCACGGCGAGCGCTGC CACGTCAGACGAAGGGCGCAGCGAGCGTCCTGATCCTTCCGCCCGGACGCTCAGGACAGCGGCCCGC TGCTCATAAGACTCGGCCTTAGAACCCCAGTATCAGCAGAAGGACATTTTAGGACGGGACTTGGGTG ACTCTAGGGCACTGGTTTTCTTTCCAGAGAGCGGAACAGGCGAGGAAAAGTAGTCCCTTCTCGGCGA TTCTGCGGAGGGATCTCCGTGGGGCGGTGAACGCCGATGATGCCTCTACTAACCATGTTCATGTTTTC TTTTTTTTTCTACAGGTCCTGGGTGACGAACAG Ad5orf6 primer 1 polynucleotide sequence SEQ ID NO: 13 ATACGGACTAGTGGAGAAGTACTCGCCTACATG Ad5orf6 primer 2 polynucleotide sequence SEQ ID NO: 14 ATACGGAAGATCTAAGACTTCAGGAAATATGACTAC BAC/CHAd155 .DELTA.E1_TetO hCMV RpsL-Kana primer 1 polynucleotide sequence SEQ ID NO: 15 ATTCAGTGTACAGGCGCGCCAAAGCATGACGCTGTTGATTTGATTC BAC/CHAd155 .DELTA.E1_TetO hCMV RpsL-Kana (#1375) primer 2 polynucleotide sequence SEQ ID NO: 16 ACTAGGACTAGTTATAAGCTAGAATGGGGCTTTGC 1021-FW E4 Del Step1 primer polynucleotide sequence SEQ ID NO: 17 TTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACCCCTATTTG TTTATTTTTCT 1022-RW E4 Del Step1 primer polynucleotide sequence SEQ ID NO: 18 ATATATACTCTCTCGGCACTTGGCCTTTTACACTGCGAAGTGTTGGTGCTGGTGCTGCGTTGAGAGAT CTTTATTTGTTAACTGTTAATTGTC 1025-FW E4 Del Step2 primer polynucleotide sequence SEQ ID NO: 19 TTAATAGACACAGTAGCTTAATA 1026-RW E4 Del Step2 primer polynucleotide sequence SEQ ID NO: 20 GGAAGGGAGTGTCTAGTGTT 91-SubMonte FW primer polynucleotide sequence SEQ ID NO: 21 CAATGGGCGTGGATAGCGGTTTGAC 90-BghPolyA RW primer polynucleotide sequence SEQ ID NO: 22 CAGCATGCCTGCTATTGTC CMVfor primer polynucleotide sequence SEQ ID NO: 23 CATCTACGTATTAGTCATCGCTATTACCA CMVrev primer polynucleotide sequence SEQ ID NO: 24 GACTTGGAAATCCCCGTGAGT CMVFAM-TAMRA qPCR probe polynucleotide sequence SEQ ID NO: 25 ACATCAATGGGCGTGGATAGCGGTT Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) polynucleotide sequence SEQ ID NO: 26 TAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTAC GCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTC CTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCG TGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTT TCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTG CTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAATCATCGTCCTTTC CTTGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCC TCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTC GCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCT ChAd3 fiber amino acid sequence SEQ ID NO: 27 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPINVSSGSLGLDMEDPMYTHDGKLGIRIGGPLR VVDSLHTLTVVTGNGLTVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILNVAYPFDAQNN LSLRLGQGPLYINTDHNLDLNCNRGLTTTTTNNTKKLETKISSGLDYDTNGAVIIKLGTGLSFDNTGALTV GNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVASVTIFLRFD QNGVLMENSSLDRQYWNFRNGNSTNAAPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ PanAd3 fiber amino acid sequence SEQ ID NO: 28 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVGTTPPISVSSGSLGLDMEDPMYTHDGKLGIRIGGPLQ VVDSLHTLTVVTGNGITVANNALQTKVAGALGYDSSGNLELRAAGGMRINTGGQLILDVAYPFDAQNNL SLRLGQGPLYVNTNHNLDLNCNRGLTTTTSSNTTKLETKIDSGLDYNANGAIIAKLGTGLTFDNTGAITVG NTGDDKLTLWTTPDPSPNCRIHADKDKFTLVLTKCGSQILASVAALAVSGNLSSMTGTVSSVTIFLRFDQN GVLMENSSLDKEYWNFRNGNSTNATPYTNAVGFMPNLSAYPKTQSQTAKNNIVSEVYLHGDKSKPMILT ITLNGTNESSETSQVSHYSMSFTWSWDSGKYATETFATNSFTFSYIAEQ ChAd17 fiber amino acid sequence SEQ ID NO: 29 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDITSTTPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLAVQDAK LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSSTPPISVSSGSLGLDMEDPMYTHDGKLGIRIGGPLRV VDSLHTLTVVTGNGLTVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQNNL SLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKISSGLDYDTNGAVIIKLGTGLSFDNTGALTV GNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVASVTIFLRFD QNGVLMENSSLDKQYWNFRNGNSTNAAPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ ChAd19 fiber amino acid sequence SEQ ID NO: 30 MKRTKTSDKSFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAAPLAVAGTSLTMQSEAPLTVQDA KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPISVSSGSLGLDMEDPMYTHDGKLGIRTGGPLR VVDSLHTLTVVTGNGIAVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQNN LSLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKIGSGLDYDTNGAVIIKLGTGVSFDSTGALS VGNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVSSVTIFLRFD QNGVLMENSSLDKQYWNFRNGNSTNATPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ ChAd24 fiber amino acid sequence SEQ ID NO: 31 MKRTKTSDESFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAAPLAVAGTSLTMQSEAPLTVQDA KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPINVSSGSLGLDMENPMYTHDGKLGIRTGGPL RVVDSLHTLTVVTGNGIAVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQN NLSLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKIGSGLDYDTNGAVIIKLGTGVSFDSTGAL SVGNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVSSVTIFLRF DQNGVLMENSSLDKQYWNFRNGNSTNATPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP MILTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ ChAd11 fiber amino acid sequence SEQ ID NO: 32 MKRTKTSDESFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAVPLAVAGTSLTMQSEAPLTVQDA KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTISATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDSSGNLELRAAGGMRVDANGKLILDVAYPFDAQNN LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINPGDGLEFGSGSDTN PLKTKLGLGLEYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVLT KCGSQVLASVSVLSVKGSLAPISGTVTSAQIILRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAVGF

MPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMILTITLNGTNETGDATVSTYSMSFSWNWNGSNYINET FQTNSFTFSYIAQE ChAd20 fiber amino acid sequence SEQ ID NO: 33 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI NETFQTNSFTFSYIAQE ChAd31 fiber amino acid sequence SEQ ID NO: 34 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI NETFQTNSFTFSYIAQE PanAd1 fiber amino acid sequence SEQ ID NO: 35 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVSATPPLSTSNGSLSIDMQAPIYTTNGKLALNIGAPLHV VDTLNALTVVTGQGLTINGRALQTRVTGALSYDTEGNIQLQAGGGMRIDNNGQLILNVAYPFDAQNNLS LRLGQGPLIVNSAHNLDLNLNRGLYLFTSGNTKKLEVNIKTAKGLFYDGTAIAINAGDGLQFGSGSDTNPL QTKLGLGLEYDSNKAIITKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRINSEKDAKLTLVLTKC GSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDSTEGTAYTNAVGFM PNLTAYPKTQSQTAKSNIVSQVYLNGDKTKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYINDTF QTNSFTFSYIAQE PanAd2 fiber amino acid sequence SEQ ID NO: 36 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVSATPPLSTSNGSLSIDMQAPIYTTNGKLALNIGAPLHV VDTLNALTVVTGQGLTINGRALQTRVTGALSYDTEGNIQLQAGGGMRIDNNGQLILNVAYPFDAQNNLS LRLGQGPLIVNSAHNLDLNLNRGLYLFTSGNTKKLEVNIKTAKGLFYDGTAIAINAGDGLQFGSGSDTNPL QTKLGLGLEYDSNKAIITKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRINSEKDAKLTLVLTKC GSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDSTEGTAYTNAVGFM PNLTAYPKTQSQTAKSNIVSQVYLNGDKTKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYINDTF QTNSFTFSYIAQE RSV F.DELTA.TM-N-M2-1 amino acid sequence SEQ ID NO: 37 MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTD AKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLL GVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCS ISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLNDMPITNDQKKLMSNNVQIVRQQSY SIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAET CKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKN RGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKIN QSLAFIRKSDELLHNVNAGKSTTNRKRRAPVKQTLNFDLLKLAGDVESNPGPMALSKVKLNDTLNKDQL LSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGY HVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGM IILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANS FYEVFEKYPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASV QAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDL YDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVELGGGGSGGGGMSRRNPCKNFIRGHC LNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGS INNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLK KTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT HIV Gag polynucleotide sequence SEQ ID NO: 38 ATGGGTGCTAGGGCTTCTGTGCTGTCTGGTGGTGAGCTGGACAAGTGGGAGAAGATCAGGCTGAGGC CTGGTGGCAAGAAGAAGTACAAGCTAAAGCACATTGTGTGGGCCTCCAGGGAGCTGGAGAGGTTTG CTGTGAACCCTGGCCTGCTGGAGACCTCTGAGGGGTGCAGGCAGATCCTGGGCCAGCTCCAGCCCTC CCTGCAAACAGGCTCTGAGGAGCTGAGGTCCCTGTACAACACAGTGGCTACCCTGTACTGTGTGCAC CAGAAGATTGATGTGAAGGACACCAAGGAGGCCCTGGAGAAGATTGAGGAGGAGCAGAACAAGTCC AAGAAGAAGGCCCAGCAGGCTGCTGCTGGCACAGGCAACTCCAGCCAGGTGTCCCAGAACTACCCC ATTGTGCAGAACCTCCAGGGCCAGATGGTGCACCAGGCCATCTCCCCCCGGACCCTGAATGCCTGGG TGAAGGTGGTGGAGGAGAGGCCTTCTCCCCTGAGGTGATCCCCATGTTCTCTGCCCTGTCTGAGGGTG CCACCCCCCAGGACCTGAACACCATGCTGAACACAGTGGGGGGCCATCAGGCTGCCATGCAGATGCT GAAGGAGACCATCAATGAGGAGGCTGCTGAGTGGGACAGGCTGCATCCTGTGCACGCTGGCCCCATT GCCCCCGGCCAGATGAGGGAGCCCAGGGGCTCTGACATTGCTGGCACCACCTCCACCCTCCAGGAGC AGATTGGCTGGATGACCAACAACCCCCCCATCCCTGTGGGGGAAATCTACAAGAGGTGGATCATCCT GGGCCTGAACAAGATTGTGAGGATGTACTCCCCCACCTCCATCCTGGACATCAGGCAGGGCCCCAAG GAGCCCTTCAGGGACTATGTGGACAGGTTCTACAAGACCCTGAGGGCTGAGCAGGCCTCCCAGGAGG TGAAGAACTGGATGACAGAGACCCTGCTGGTGCAGAATGCCAACCCTGACTGCAAGACCATCCTGAA GGCCCTGGGCCCTGCTGCCACCCTGGAGGAGATGATGACAGCCTGCCAGGGGGTGGGGGGCCCTGGT CACAAGGCCAGGGTGCTGGCTGAGGCCATGTCCCAGGTGACCAACTCCGCCACCATCATGATGCAGA GGGGCAACTTCAGGAACCAGAGGAAGACAGTGAAGTGCTTCAACTGTGGCAAGGTGGGCCACATTG CCAAGAACTGTAGGGCCCCCAGGAAGAAGGGCTGCTGGAAGTGTGGCAAGGAGGGCCACCAGATGA AGGACTGCAATGAGAGGCAGGCCAACTTCCTGGGCAAAATCTGGCCCTCCCACAAGGGCAGGCCTG GCAACTTCCTCCAGTCCAGGCCTGAGCCCACAGCCCCTCCCGAGGAGTCCTTCAGGTTTGGGGAGGA GAAGACCACCCCCAGCCAGAAGCAGGAGCCCATTGACAAGGAGCTGTACCCCCTGGCCTCCCTGAG GTCCCTGTTTGGCAACGACCCCTCCTCCCAGTAA

Sequence CWU 1

1

381578PRTSimian adenovirus 1Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Ser Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Ile Thr Thr Ala Ser Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ser Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Gly Ile Asp 180 185 190Met Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Gly Leu Asn Phe 195 200 205Gly Ala Pro Leu His Val Val Asp Ser Leu Asn Ala Leu Thr Val Val 210 215 220Thr Gly Gln Gly Leu Thr Ile Asn Gly Thr Ala Leu Gln Thr Arg Val225 230 235 240Ser Gly Ala Leu Asn Tyr Asp Thr Ser Gly Asn Leu Glu Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Val Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Phe Val Asn Ser Ala His Asn Leu Asp Val Asn Tyr Asn 290 295 300Arg Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val305 310 315 320Asn Ile Lys Thr Ala Lys Gly Leu Ile Tyr Asp Asp Thr Ala Ile Ala 325 330 335Ile Asn Ala Gly Asp Gly Leu Gln Phe Asp Ser Gly Ser Asp Thr Asn 340 345 350Pro Leu Lys Thr Lys Leu Gly Leu Gly Leu Asp Tyr Asp Ser Ser Arg 355 360 365Ala Ile Ile Ala Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly 370 375 380Ala Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr385 390 395 400Thr Pro Asp Pro Ser Pro Asn Cys Arg Ile Tyr Ser Glu Lys Asp Ala 405 410 415Lys Phe Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser 420 425 430Val Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr 435 440 445Val Thr Ser Ala Gln Ile Val Leu Arg Phe Asp Glu Asn Gly Val Leu 450 455 460Leu Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly465 470 475 480Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro 485 490 495Asn Leu Thr Ala Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Ser Asn 500 505 510Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr 515 520 525Leu Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val 530 535 540Ser Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr545 550 555 560Ile Asn Glu Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala 565 570 575Gln Glu21734DNASimian adenovirus 2atgaagcgca ccaaaacgtc tgacgagagc ttcaaccccg tgtaccccta tgacacggaa 60agcggccctc cctccgtccc tttcctcacc cctcccttcg tgtctcccga tggattccaa 120gaaagtcccc ccggggtcct gtctctgaac ctggccgagc ccctggtcac ttcccacggc 180atgctcgccc tgaaaatggg aagtggcctc tccctggacg acgctggcaa cctcacctct 240caagatatca ccaccgctag ccctcccctc aaaaaaacca agaccaacct cagcctagaa 300acctcatccc ccctaactgt gagcacctca ggcgccctca ccgtagcagc cgccgctccc 360ctggcggtgg ccggcacctc cctcaccatg caatcagagg cccccctgac agtacaggat 420gcaaaactca ccctggccac caaaggcccc ctgaccgtgt ctgaaggcaa actggccttg 480caaacatcgg ccccgctgac ggccgctgac agcagcaccc tcacagtcag tgccacacca 540ccccttagca caagcaatgg cagcttgggt attgacatgc aagcccccat ttacaccacc 600aatggaaaac taggacttaa ctttggcgct cccctgcatg tggtagacag cctaaatgca 660ctgactgtag ttactggcca aggtcttacg ataaacggaa cagccctaca aactagagtc 720tcaggtgccc tcaactatga cacatcagga aacctagaat tgagagctgc agggggtatg 780cgagttgatg caaatggtca acttatcctt gatgtagctt acccatttga tgcacaaaac 840aatctcagcc ttaggcttgg acagggaccc ctgtttgtta actctgccca caacttggat 900gttaactaca acagaggcct ctacctgttc acatctggaa ataccaaaaa gctagaagtt 960aatatcaaaa cagccaaggg tctcatttat gatgacactg ctatagcaat caatgcgggt 1020gatgggctac agtttgactc aggctcagat acaaatccat taaaaactaa acttggatta 1080ggactggatt atgactccag cagagccata attgctaaac tgggaactgg cctaagcttt 1140gacaacacag gtgccatcac agtaggcaac aaaaatgatg acaagcttac cttgtggacc 1200acaccagacc catcccctaa ctgtagaatc tattcagaga aagatgctaa attcacactt 1260gttttgacta aatgcggcag tcaggtgttg gccagcgttt ctgttttatc tgtaaaaggt 1320agccttgcgc ccatcagtgg cacagtaact agtgctcaga ttgtcctcag atttgatgaa 1380aatggagttc tactaagcaa ttcttccctt gaccctcaat actggaacta cagaaaaggt 1440gaccttacag agggcactgc atataccaac gcagtgggat ttatgcccaa cctcacagca 1500tacccaaaaa cacagagcca aactgctaaa agcaacattg taagtcaggt ttacttgaat 1560ggggacaaat ccaaacccat gaccctcacc attaccctca atggaactaa tgaaacagga 1620gatgccacag taagcactta ctccatgtca ttctcatgga actggaatgg aagtaattac 1680attaatgaaa cgttccaaac caactccttc accttctcct acatcgccca agaa 17343593PRTSimian adenovirus 3Met Arg Arg Ala Ala Met Tyr Gln Glu Gly Pro Pro Pro Ser Tyr Glu1 5 10 15Ser Val Val Gly Ala Ala Ala Ala Ala Pro Ser Ser Pro Phe Ala Ser 20 25 30Gln Leu Leu Glu Pro Pro Tyr Val Pro Pro Arg Tyr Leu Arg Pro Thr 35 40 45Gly Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Phe Asp 50 55 60Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Ala Asp Val Ala Ser65 70 75 80Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Ile Gln 85 90 95Asn Asn Asp Tyr Ser Pro Ser Glu Ala Ser Thr Gln Thr Ile Asn Leu 100 105 110Asp Asp Arg Ser His Trp Gly Gly Asp Leu Lys Thr Ile Leu His Thr 115 120 125Asn Met Pro Asn Val Asn Glu Phe Met Phe Thr Asn Lys Phe Lys Ala 130 135 140Arg Val Met Val Ser Arg Ser His Thr Lys Glu Asp Arg Val Glu Leu145 150 155 160Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Tyr Ser Glu 165 170 175Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Val Glu His Tyr Leu 180 185 190Lys Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys 195 200 205Phe Asp Thr Arg Asn Phe Arg Leu Gly Leu Asp Pro Val Thr Gly Leu 210 215 220Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile Ile225 230 235 240Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Tyr Ser Arg Leu Ser Asn 245 250 255Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Arg Ile 260 265 270Thr Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val 275 280 285Glu Ala Tyr Gln Asp Ser Leu Lys Glu Asn Glu Ala Gly Gln Glu Asp 290 295 300Thr Ala Pro Ala Ala Ser Ala Ala Ala Glu Gln Gly Glu Asp Ala Ala305 310 315 320Asp Thr Ala Ala Ala Asp Gly Ala Glu Ala Asp Pro Ala Met Val Val 325 330 335Glu Ala Pro Glu Gln Glu Glu Asp Met Asn Asp Ser Ala Val Arg Gly 340 345 350Asp Thr Phe Val Thr Arg Gly Glu Glu Lys Gln Ala Glu Ala Glu Ala 355 360 365Ala Ala Glu Glu Lys Gln Leu Ala Ala Ala Ala Ala Ala Ala Ala Leu 370 375 380Ala Ala Ala Glu Ala Glu Ser Glu Gly Thr Lys Pro Ala Lys Glu Pro385 390 395 400Val Ile Lys Pro Leu Thr Glu Asp Ser Lys Lys Arg Ser Tyr Asn Leu 405 410 415Leu Lys Asp Ser Thr Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr 420 425 430Asn Tyr Gly Asp Pro Ser Thr Gly Val Arg Ser Trp Thr Leu Leu Cys 435 440 445Thr Pro Asp Val Thr Cys Gly Ser Glu Gln Val Tyr Trp Ser Leu Pro 450 455 460Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser465 470 475 480Asn Phe Pro Val Val Gly Ala Glu Leu Leu Pro Val His Ser Lys Ser 485 490 495Phe Tyr Asn Asp Gln Ala Val Tyr Ser Gln Leu Ile Arg Gln Phe Thr 500 505 510Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ala 515 520 525Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala 530 535 540Leu Thr Asp His Gly Thr Leu Pro Leu Arg Asn Ser Ile Gly Gly Val545 550 555 560Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val 565 570 575Tyr Lys Ala Leu Gly Ile Val Ser Pro Arg Val Leu Ser Ser Arg Thr 580 585 590Phe41779DNASimian adenovirus 4atgcggcgcg cggcgatgta ccaggaggga cctcctccct cttacgagag cgtggtgggc 60gcggcggcgg cggcgccctc ttctcccttt gcgtcgcagc tgctggagcc gccgtacgtg 120cctccgcgct acctgcggcc tacggggggg agaaacagca tccgttactc ggagctggcg 180cccctgttcg acaccacccg ggtgtacctg gtggacaaca agtcggcgga cgtggcctcc 240ctgaactacc agaacgacca cagcaatttt ttgaccacgg tcatccagaa caatgactac 300agcccgagcg aggccagcac ccagaccatc aatctggatg accggtcgca ctggggcggc 360gacctgaaaa ccatcctgca caccaacatg cccaacgtga acgagttcat gttcaccaat 420aagttcaagg cgcgggtgat ggtgtcgcgc tcgcacacca aggaagaccg ggtggagctg 480aagtacgagt gggtggagtt cgagctgcca gagggcaact actccgagac catgaccatt 540gacctgatga acaacgcgat cgtggagcac tatctgaaag tgggcaggca gaacggggtc 600ctggagagcg acatcggggt caagttcgac accaggaact tccgcctggg gctggacccc 660gtgaccgggc tggttatgcc cggggtgtac accaacgagg ccttccatcc cgacatcatc 720ctgctgcccg gctgcggggt ggacttcact tacagccgcc tgagcaacct cctgggcatc 780cgcaagcggc agcccttcca ggagggcttc aggatcacct acgaggacct ggaggggggc 840aacatccccg cgctcctcga tgtggaggcc taccaggata gcttgaagga aaatgaggcg 900ggacaggagg ataccgcccc cgccgcctcc gccgccgccg agcagggcga ggatgctgct 960gacaccgcgg ccgcggacgg ggcagaggcc gaccccgcta tggtggtgga ggctcccgag 1020caggaggagg acatgaatga cagtgcggtg cgcggagaca ccttcgtcac ccggggggag 1080gaaaagcaag cggaggccga ggccgcggcc gaggaaaagc aactggcggc agcagcggcg 1140gcggcggcgt tggccgcggc ggaggctgag tctgagggga ccaagcccgc caaggagccc 1200gtgattaagc ccctgaccga agatagcaag aagcgcagtt acaacctgct caaggacagc 1260accaacaccg cgtaccgcag ctggtacctg gcctacaact acggcgaccc gtcgacgggg 1320gtgcgctcct ggaccctgct gtgcacgccg gacgtgacct gcggctcgga gcaggtgtac 1380tggtcgctgc ccgacatgat gcaagacccc gtgaccttcc gctccacgcg gcaggtcagc 1440aacttcccgg tggtgggcgc cgagctgctg cccgtgcact ccaagagctt ctacaacgac 1500caggccgtct actcccagct catccgccag ttcacctctc tgacccacgt gttcaatcgc 1560tttcctgaga accagattct ggcgcgcccg cccgccccca ccatcaccac cgtcagtgaa 1620aacgttcctg ctctcacaga tcacgggacg ctaccgctgc gcaacagcat cggaggagtc 1680cagcgagtga ccgttactga cgccagacgc cgcacctgcc cctacgttta caaggccttg 1740ggcatagtct cgccgcgcgt cctttccagc cgcactttt 17795964PRTSimian adenovirus 5Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser1 5 10 15Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30Arg Ala Thr Asp Ser Tyr Phe Ser Leu Ser Asn Lys Phe Arg Asn Pro 35 40 45Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr65 70 75 80Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Thr Gln Thr Ala Glu 130 135 140Glu Ala Gln Asp Glu Glu Glu Asp Glu Ala Glu Ala Glu Glu Glu Met145 150 155 160Pro Gln Glu Glu Gln Ala Pro Val Lys Lys Thr His Val Tyr Ala Gln 165 170 175Ala Pro Leu Ser Gly Glu Lys Ile Thr Lys Asp Gly Leu Gln Ile Gly 180 185 190Thr Asp Ala Thr Ala Thr Glu Gln Lys Pro Ile Tyr Ala Asp Pro Thr 195 200 205Phe Gln Pro Glu Pro Gln Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp 210 215 220Ala Ser Val Ala Gly Gly Arg Val Leu Lys Lys Thr Thr Pro Met Lys225 230 235 240Pro Cys Tyr Gly Ser Tyr Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln 245 250 255Gly Val Leu Val Glu Lys Asp Gly Gly Lys Met Glu Ser Gln Val Asp 260 265 270Met Gln Phe Phe Ser Thr Ser Glu Asn Ala Arg Asn Glu Ala Asn Asn 275 280 285Ile Gln Pro Lys Leu Val Leu Tyr Ser Glu Asp Val His Met Glu Thr 290 295 300Pro Asp Thr His Ile Ser Tyr Lys Pro Ala Lys Ser Asp Asp Asn Ser305 310 315 320Lys Val Met Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile 325 330 335Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly 340 345 350Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 355 360 365Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp 370 375 380Ser Met Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val385 390 395 400Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Thr Glu 405 410 415Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Val Thr 420 425 430Asp Thr Tyr Gln Ala Ile Lys Thr Asn Gly Asn Gly Asn Gly Gly Gly 435 440 445Asn Thr Thr Trp Thr Lys Asp Glu Thr Phe Ala Asp Arg Asn Glu Ile 450 455 460Gly Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu Ser Ala Asn Leu465 470 475 480Trp Arg Asn Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Lys 485 490 495Leu Lys Tyr Asn Pro Ser Asn Val Glu Ile Ser Asp Asn Pro Asn Thr 500 505 510Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu Val Asp Cys 515 520 525Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met Asp Asn Val 530 535 540Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met545 550 555 560Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln 565 570 575Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr 580 585 590Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser Ser 595 600 605Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys Phe Glu Ser 610 615 620Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser625 630 635 640Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn 645 650 655Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 660 665 670Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg 675 680 685Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly 690 695 700Ser Gly Phe Asp Pro

Tyr Tyr Thr Tyr Ser Gly Ser Ile Pro Tyr Leu705 710 715 720Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Val Thr 725 730 735Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro 740 745 750Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val 755 760 765Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Ile Gln Met Leu Ala 770 775 780Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu Ser Tyr Lys785 790 795 800Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln 805 810 815Val Val Asp Glu Thr Lys Tyr Lys Asp Tyr Gln Gln Val Gly Ile Ile 820 825 830His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met 835 840 845Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro Leu Ile Gly 850 855 860Lys Thr Ala Val Asp Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg865 870 875 880Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala 885 890 895Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala 900 905 910Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu 915 920 925Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His 930 935 940Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly945 950 955 960Asn Ala Thr Thr62880DNASimian adenovirus 6atggcgaccc catcgatgat gccgcagtgg tcgtacatgc acatctcggg ccaggacgcc 60tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg ccaccgagag ctacttcagc 120ctgagtaaca agtttaggaa ccccacggtg gcgcccacgc acgatgtgac caccgaccgg 180tctcagcgcc tgacgctgcg gttcattccc gtggaccgcg aggacaccgc gtactcgtac 240aaggcgcggt tcaccctggc cgtgggcgac aaccgcgtgc tggacatggc ctccacctac 300tttgacatcc gcggggtgct ggaccggggt cccactttca agccctactc tggcaccgcc 360tacaactccc tggcccccaa gggcgctccc aactcctgcg agtgggagca agaggaaact 420caggcagttg aagaagcagc agaagaggaa gaagaagatg ctgacggtca agctgaggaa 480gagcaagcag ctaccaaaaa gactcatgta tatgctcagg ctcccctttc tggcgaaaaa 540attagtaaag atggtctgca aataggaacg gacgctacag ctacagaaca aaaacctatt 600tatgcagacc ctacattcca gcccgaaccc caaatcgggg agtcccagtg gaatgaggca 660gatgctacag tcgccggcgg tagagtgcta aagaaatcta ctcccatgaa accatgctat 720ggttcctatg caagacccac aaatgctaat ggaggtcagg gtgtactaac ggcaaatgcc 780cagggacagc tagaatctca ggttgaaatg caattctttt caacttctga aaacgcccgt 840aacgaggcta acaacattca gcccaaattg gtgctgtata gtgaggatgt gcacatggag 900accccggata cgcacctttc ttacaagccc gcaaaaagcg atgacaattc aaaaatcatg 960ctgggtcagc agtccatgcc caacagacct aattacatcg gcttcagaga caactttatc 1020ggcctcatgt attacaatag cactggcaac atgggagtgc ttgcaggtca ggcctctcag 1080ttgaatgcag tggtggactt gcaagacaga aacacagaac tgtcctacca gctcttgctt 1140gattccatgg gtgacagaac cagatacttt tccatgtgga atcaggcagt ggacagttat 1200gacccagatg ttagaattat tgaaaatcat ggaactgaag acgagctccc caactattgt 1260ttccctctgg gtggcatagg ggtaactgac acttaccagg ctgttaaaac caacaatggc 1320aataacgggg gccaggtgac ttggacaaaa gatgaaactt ttgcagatcg caatgaaata 1380ggggtgggaa acaatttcgc tatggagatc aacctcagtg ccaacctgtg gagaaacttc 1440ctgtactcca acgtggcgct gtacctacca gacaagctta agtacaaccc ctccaatgtg 1500gacatctctg acaaccccaa cacctacgat tacatgaaca agcgagtggt ggccccgggg 1560ctggtggact gctacatcaa cctgggcgcg cgctggtcgc tggactacat ggacaacgtc 1620aaccccttca accaccaccg caatgcgggc ctgcgctacc gctccatgct cctgggcaac 1680gggcgctacg tgcccttcca catccaggtg ccccagaagt tctttgccat caagaacctc 1740ctcctcctgc cgggctccta cacctacgag tggaacttca ggaaggatgt caacatggtc 1800ctccagagct ctctgggtaa cgatctcagg gtggacgggg ccagcatcaa gttcgagagc 1860atctgcctct acgccacctt cttccccatg gcccacaaca cggcctccac gctcgaggcc 1920atgctcagga acgacaccaa cgaccagtcc ttcaatgact acctctccgc cgccaacatg 1980ctctacccca tacccgccaa cgccaccaac gtccccatct ccatcccctc gcgcaactgg 2040gcggccttcc gcggctgggc cttcacccgc ctcaagacca aggagacccc ctccctgggc 2100tcgggattcg acccctacta cacctactcg ggctccattc cctacctgga cggcaccttc 2160tacctcaacc acactttcaa gaaggtctcg gtcaccttcg actcctcggt cagctggccg 2220ggcaacgacc gtctgctcac ccccaacgag ttcgagatca agcgctcggt cgacggggag 2280ggctacaacg tggcccagtg caacatgacc aaggactggt tcctggtcca gatgctggcc 2340aactacaaca tcggctacca gggcttctac atcccagaga gctacaagga caggatgtac 2400tccttcttca ggaacttcca gcccatgagc cggcaggtgg tggaccagac caagtacaag 2460gactaccagg aggtgggcat catccaccag cacaacaact cgggcttcgt gggctacctc 2520gcccccacca tgcgcgaggg acaggcctac cccgccaact tcccctatcc gctcataggc 2580aagaccgcgg tcgacagcat cacccagaaa aagttcctct gcgaccgcac cctctggcgc 2640atccccttct ccagcaactt catgtccatg ggtgcgctct cggacctggg ccagaacttg 2700ctctacgcca actccgccca cgccctcgac atgaccttcg aggtcgaccc catggacgag 2760cccacccttc tctatgttct gttcgaagtc tttgacgtgg tccgggtcca ccagccgcac 2820cgcggcgtca tcgagaccgt gtacctgcgt acgcccttct cggccggcaa cgccaccacc 2880737912DNASimian adenovirus 7catcatcaat aatatacctt attttggatt gaagccaata tgataatgag atgggcggcg 60cggggcgggg cgcggggcgg gaggcgggtt tgggggcggg ccggcgggcg gggcggtgtg 120gcggaagtgg actttgtaag tgtggcggat gtgacttgct agtgccgggc gcggtaaaag 180tgacgttttc cgtgcgcgac aacgcccccg ggaagtgaca tttttcccgc ggtttttacc 240ggatgttgta gtgaatttgg gcgtaaccaa gtaagatttg gccattttcg cgggaaaact 300gaaacgggga agtgaaatct gattaatttt gcgttagtca taccgcgtaa tatttgtcta 360gggccgaggg actttggccg attacgtgga ggactcgccc aggtgttttt tgaggtgaat 420ttccgcgttc cgggtcaaag tctgcgtttt attattatag gatatcccat tgcatacgtt 480gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg 540acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 600atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 660cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 720tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 780agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 840gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 900agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 960gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 1020gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 1080gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag 1140agatctccct atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc 1200ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct 1260ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg agatcttccg 1320tttatctagg taccgggccc cccctcgagg tcgacggtat cgataagctt cacgctgccg 1380caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag ccagtccgca 1440gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc 1500aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc 1560ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg 1620gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat ggcgcagggg 1680atcaagatct aaccaggagc tatttaatgg caacagttaa ccagctggta cgcaaaccac 1740gtgctcgcaa agttgcgaaa agcaacgtgc ctgcgctgga agcatgcccg caaaaacgtg 1800gcgtatgtac tcgtgtatat actaccactc ctaaaaaacc gaactccgcg ctgcgtaaag 1860tatgccgtgt tcgtctgact aacggtttcg aagtgacttc ctacatcggt ggtgaaggtc 1920acaacctgca ggagcactcc gtgatcctga tccgtggcgg tcgtgttaaa gacctcccgg 1980gtgttcgtta ccacaccgta cgtggtgcgc ttgactgctc cggcgttaaa gaccgtaagc 2040aggctcgttc caagtatggc gtgaagcgtc ctaaggctta atggtagatc tgatcaagag 2100acaggatgac ggtcgtttcg catgcttgaa caagatggat tgcacgcagg ttctccggcc 2160gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat 2220gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg 2280tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg 2340ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta 2400ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta 2460tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc 2520gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc 2580gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg 2640ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg 2700ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt 2760gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc 2820ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc 2880atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga 2940ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg 3000aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg 3060atctcatgct ggagttcttc gcccaccccg ggctcgatcc cctcgggggg aatcagaatt 3120cagtcgacag cggccgcgat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc 3180ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 3240tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 3300gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg 3360ctctatggcc gatcagcgat cgctgaggtg ggtgagtggg cgtggcctgg ggtggtcatg 3420aaaatatata agttgggggt cttagggtct ctttatttgt gttgcagaga ccgccggagc 3480catgagcggg agcagcagca gcagcagtag cagcagcgcc ttggatggca gcatcgtgag 3540cccttatttg acgacgcgga tgccccactg ggccggggtg cgtcagaatg tgatgggctc 3600cagcatcgac ggccgacccg tcctgcccgc aaattccgcc acgctgacct atgcgaccgt 3660cgcggggacg ccgttggacg ccaccgccgc cgccgccgcc accgcagccg cctcggccgt 3720gcgcagcctg gccacggact ttgcattcct gggaccactg gcgacagggg ctacttctcg 3780ggccgctgct gccgccgttc gcgatgacaa gctgaccgcc ctgctggcgc agttggatgc 3840gcttactcgg gaactgggtg acctttctca gcaggtcatg gccctgcgcc agcaggtctc 3900ctccctgcaa gctggcggga atgcttctcc cacaaatgcc gtttaagata aataaaacca 3960gactctgttt ggattaaaga aaagtagcaa gtgcattgct ctctttattt cataattttc 4020cgcgcgcgat aggccctaga ccagcgttct cggtcgttga gggtgcggtg tatcttctcc 4080aggacgtggt agaggtggct ctggacgttg agatacatgg gcatgagccc gtcccggggg 4140tggaggtagc accactgcag agcttcatgc tccggggtgg tgttgtagat gatccagtcg 4200tagcaggagc gctgggcatg gtgcctaaaa atgtccttca gcagcaggcc gatggccagg 4260gggaggccct tggtgtaagt gtttacaaaa cggttaagtt gggaagggtg cattcgggga 4320gagatgatgt gcatcttgga ctgtattttt agattggcga tgtttccgcc cagatccctt 4380ctgggattca tgttgtgcag gaccaccagt acagtgtatc cggtgcactt ggggaatttg 4440tcatgcagct tagagggaaa agcgtggaag aacttggaga cgcctttgtg gcctcccaga 4500ttttccatgc attcgtccat gatgatggca atgggcccgc gggaggcagc ttgggcaaag 4560atatttctgg ggtcgctgac gtcgtagttg tgttccaggg tgaggtcgtc ataggccatt 4620tttacaaagc gcgggcggag ggtgcccgac tgggggatga tggtcccctc tggccctggg 4680gcgtagttgc cctcgcagat ctgcatttcc caggccttaa tctcggaggg gggaatcata 4740tccacctgcg gggcgatgaa gaaaacggtt tccggagccg gggagattaa ctgggatgag 4800agcaggtttc taagcagctg tgattttcca caaccggtgg gcccataaat aacacctata 4860accggttgca gctggtagtt tagagagctg cagctgccgt cgtcccggag gaggggggcc 4920acctcgttga gcatgtccct gacgcgcatg ttctccccga ccagatccgc cagaaggcgc 4980tcgccgccca gggacagcag ctcttgcaag gaagcaaagt ttttcagcgg cttgaggccg 5040tccgccgtgg gcatgttttt cagggtctgg ctcagcagct ccaggcggtc ccagagctcg 5100gtgacgtgct ctacggcatc tctatccagc atatctcctc gtttcgcggg ttggggcgac 5160tttcgctgta gggcaccaag cggtggtcgt ccagcggggc cagagtcatg tccttccatg 5220ggcgcagggt cctcgtcagg gtggtctggg tcacggtgaa ggggtgcgct ccgggctgag 5280cgcttgccaa ggtgcgcttg aggctggttc tgctggtgct gaagcgctgc cggtcttcgc 5340cctgcgcgtc ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt 5400gtcccttggc gcgcagcttg cccttggagg tggcgccgca cgaggggcag agcaggctct 5460tgagcgcgta gagcttgggg gcgaggaaga ccgattcggg ggagtaggcg tccgcgccgc 5520agaccccgca cacggtctcg cactccacca gccaggtgag ctcggggcgc gccgggtcaa 5580aaaccaggtt tcccccatgc tttttgatgc gtttcttacc tcgggtctcc atgaggtggt 5640gtccccgctc ggtgacgaag aggctgtccg tgtctccgta gaccgacttg aggggtcttt 5700tctccagggg ggtccctcgg tcttcctcgt agaggaactc ggaccactct gagacgaagg 5760cccgcgtcca ggccaggacg aaggaggcta tgtgggaggg gtagcggtcg ttgtccacta 5820gggggtccac cttctccaag gtgtgaagac acatgtcgcc ttcctcggcg tccaggaagg 5880tgattggctt gtaggtgtag gccacgtgac cgggggttcc tgacgggggg gtataaaagg 5940gggtgggggc gcgctcgtcg tcactctctt ccgcatcgct gtctgcgagg gccagctgct 6000ggggtgagta ttccctctcg aaggcgggca tgacctccgc gctgaggttg tcagtttcca 6060aaaacgagga ggatttgatg ttcacctgtc ccgaggtgat acctttgagg gtacccgcgt 6120ccatctggtc agaaaacacg atctttttat tgtccagctt ggtggcgaac gacccgtaga 6180gggcgttgga gagcagcttg gcgatggagc gcagggtctg gttcttgtcc ctgtcggcgc 6240gctccttggc cgcgatgttg agctgcacgt actcgcgcgc gacgcagcgc cactcgggga 6300agacggtggt gcgctcgtcg ggcaccaggc gcacgcgcca gccgcggttg tgcagggtga 6360ccaggtccac gctggtggcg acctcgccgc gcaggcgctc gttggtccag cagagacggc 6420cgcccttgcg cgagcagaag gggggcaggg ggtcgagctg ggtctcgtcc ggggggtccg 6480cgtccacggt gaaaaccccg gggcgcaggc gcgcgtcgaa gtagtctatc ttgcaacctt 6540gcatgtccag cgcctgctgc cagtcgcggg cggcgagcgc gcgctcgtag gggttgagcg 6600gcgggcccca gggcatgggg tgggtgagtg cggaggcgta catgccgcag atgtcataga 6660cgtagagggg ctcccgcagg accccgatgt aggtggggta gcagcggccg ccgcggatgc 6720tggcgcgcac gtagtcatac agctcgtgcg agggggcgag gaggtcgggg cccaggttgg 6780tgcgggcggg gcgctccgcg cggaagacga tctgcctgaa gatggcatgc gagttggaag 6840agatggtggg gcgctggaag acgttgaagc tggcgtcctg caggccgacg gcgtcgcgca 6900cgaaggaggc gtaggagtcg cgcagcttgt gtaccagctc ggcggtgacc tgcacgtcga 6960gcgcgcagta gtcgagggtc tcgcggatga tgtcatattt agcctgcccc ttctttttcc 7020acagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcgggaaac 7080cgtccggttc cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc 7140agcagccctt ctccacgggg agggcgtagg cctgcgcggc cttgcggagc gaggtgtggg 7200tcagggcgaa ggtgtccctg accatgactt tgaggtactg gtgcttgaag tcggagtcgt 7260cgcagccgcc ccgctcccag agcgagaagt cggtgcgctt cttggagcgg gggttgggca 7320gagcgaaggt gacatcgttg aagaggattt tgcccgcgcg gggcatgaag ttgcgggtga 7380tgcggaaggg ccccggcact tcagagcggt tgttgatgac ctgggcggcg agcacgatct 7440cgtcgaagcc gttgatgttg tggcccacga tgtagagttc caggaagcgg ggccggccct 7500ttacggtggg cagcttcttt agctcttcgt aggtgagctc ctcgggcgag gcgaggccgt 7560gctcggccag ggcccagtcc gcgaggtgcg ggttgtctct gaggaaggac ttccagaggt 7620cgcgggccag gagggtctgc aggcggtctc tgaaggtcct gaactggcgg cccacggcca 7680ttttttcggg ggtgatgcag tagaaggtga gggggtcttg ctgccagcgg tcccagtcga 7740gctgcagggc gaggtcgcgc gcggcggtga ccaggcgctc gtcgcccccg aatttcatga 7800ccagcatgaa gggcacgagc tgctttccga aggcccccat ccaagtgtag gtctctacat 7860cgtaggtgac aaagaggcgc tccgtgcgag gatgcgagcc gatcgggaag aactggatct 7920cccgccacca gttggaggag tggctgttga tgtggtggaa gtagaagtcc cgtcgccggg 7980ccgaacactc gtgctggctt ttgtaaaagc gagcgcagta ctggcagcgc tgcacgggct 8040gtacctcatg cacgagatgc acctttcgcc cgcgcacgag gaagccgagg ggaaatctga 8100gccccccgcc tggctcgcgg catggctggt tctcttctac tttggatgcg tgtccgtctc 8160cgtctggctc ctcgaggggt gttacggtgg agcggaccac cacgccgcgc gagccgcagg 8220tccagatatc ggcgcgcggc ggtcggagtt tgatgacgac atcgcgcagc tgggagctgt 8280ccatggtctg gagctcccgc ggcggcggca ggtcagccgg gagttcttgc aggttcacct 8340cgcagagtcg ggccagggcg cggggcaggt ctaggtggta cctgatctct aggggcgtgt 8400tggtggcggc gtcgatggct tgcaggagcc cgcagccccg gggggcgacg acggtgcccc 8460gcggggtggt ggtggtggtg gcggtgcagc tcagaagcgg tgccgcgggc gggcccccgg 8520aggtaggggg ggctccggtc ccgcgggcag gggcggcagc ggcacgtcgg cgtggagcgc 8580gggcaggagt tggtgctgtg cccggaggtt gctggcgaag gcgacgacgc ggcggttgat 8640ctcctggatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga acctgaaaga 8700gagttcgaca gaatcaatct cggtgtcatt gaccgcggcc tggcgcagga tctcctgcac 8760gtctcccgag ttgtcttggt aggcgatctc ggccatgaac tgctcgatct cttcctcctg 8820gaggtctccg cgtccggcgc gttccacggt ggccgccagg tcgttggaga tgcgccccat 8880gagctgcgag aaggcgttga gtccgccctc gttccagact cggctgtaga ccacgccccc 8940ctggtcatcg cgggcgcgca tgaccacctg cgcgaggttg agctccacgt gccgcgcgaa 9000gacggcgtag ttgcgcagac gctggaagag gtagttgagg gtggtggcgg tgtgctcggc 9060cacgaagaag ttcatgaccc agcggcgcaa cgtggattcg ttgatgtccc ccaaggcctc 9120cagccgttcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 9180cgacacggtc aactcctcct ccagaagacg gatgagctcg gcgacggtgt cgcgcacctc 9240gcgctcgaag gctatgggga tctcttcctc cgctagcatc accacctcct cctcttcctc 9300ctcttctggc acttccatga tggcttcctc ctcttcgggg ggtggcggcg gcggcggtgg 9360gggagggggc gctctgcgcc ggcggcggcg caccgggagg cggtccacga agcgcgcgat 9420catctccccg cggcggcggc gcatggtctc ggtgacggcg cggccgttct cccgggggcg 9480cagttggaag acgccgccgg acatctggtg ctggggcggg tggccgtgag gcagcgagac 9540ggcgctgacg atgcatctca acaattgctg cgtaggtacg ccgccgaggg acctgaggga 9600gtccatatcc accggatccg aaaacctttc gaggaaggcg tctaaccagt cgcagtcgca 9660aggtaggctg agcaccgtgg cgggcggcgg ggggtggggg gagtgtctgg cggaggtgct 9720gctgatgatg taattgaagt aggcggactt gacacggcgg atggtcgaca ggagcaccat 9780gtccttgggt ccggcctgct ggatgcggag gcggtcggct atgccccagg cttcgttctg 9840gcatcggcgc aggtccttgt agtagtcttg catgagcctt tccaccggca cctcttctcc 9900ttcctcttct gcttcttcca tgtctgcttc ggccctgggg cggcgccgcg cccccctgcc 9960ccccatgcgc gtgaccccga accccctgag cggttggagc agggccaggt cggcgacgac 10020gcgctcggcc aggatggcct gctgcacctg cgtgagggtg gtttggaagt catccaagtc 10080cacgaagcgg tggtaggcgc ccgtgttgat ggtgtaggtg cagttggcca tgacggacca 10140gttgacggtc tggtggcccg gttgcgacat ctcggtgtac ctgagtcgcg agtaggcgcg 10200ggagtcgaag acgtagtcgt tgcaagtccg caccaggtac tggtagccca ccaggaagtg 10260cggcggcggc tggcggtaga ggggccagcg cagggtggcg ggggctccgg gggccaggtc 10320ttccagcatg aggcggtggt aggcgtagat gtacctggac atccaggtga tacccgcggc 10380ggtggtggag gcgcgcggga agtcgcgcac ccggttccag atgttgcgca ggggcagaaa 10440gtgctccatg gtaggcgtgc tctgtccagt cagacgcgcg cagtcgttga tactctagac 10500cagggaaaac gaaagccggt cagcgggcac tcttccgtgg tctggtgaat agatcgcaag

10560ggtatcatgg cggagggcct cggttcgagc cccgggtccg ggccggacgg tccgccatga 10620tccacgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca acggtggagt 10680gttccttttg gcgtttttct ggccgggcgc cggcgccgcg taagagacta agccgcgaaa 10740gcgaaagcag taagtggctc gctccccgta gccggaggga tccttgctaa gggttgcgtt 10800gcggcgaacc ccggttcgaa tcccgtactc gggccggccg gacccgcggc taaggtgttg 10860gattggcctc cccctcgtat aaagaccccg cttgcggatt gactccggac acggggacga 10920gcccctttta tttttgcttt ccccagatgc atccggtgct gcggcagatg cgccccccgc 10980cccagcagca gcaacaacac cagcaagagc ggcagcaaca gcagcgggag tcatgcaggg 11040ccccctcacc caccctcggc gggccggcca cctcggcgtc cgcggccgtg tctggcgcct 11100gcggcggcgg cggggggccg gctgacgacc ccgaggagcc cccgcggcgc agggccagac 11160actacctgga cctggaggag ggcgagggcc tggcgcggct gggggcgccg tctcccgagc 11220gccacccgcg ggtgcagctg aagcgcgact cgcgcgaggc gtacgtgcct cggcagaacc 11280tgttcaggga ccgcgcgggc gaggagcccg aggagatgcg ggacaggagg ttcagcgcag 11340ggcgggagct gcggcagggg ctgaaccgcg agcggctgct gcgcgaggag gactttgagc 11400ccgacgcgcg gacggggatc agccccgcgc gcgcgcacgt ggcggccgcc gacctggtga 11460cggcgtacga gcagacggtg aaccaggaga tcaacttcca aaagagtttc aacaaccacg 11520tgcgcacgct ggtggcgcgc gaggaggtga ccatcgggct gatgcacctg tgggactttg 11580taagcgcgct ggtgcagaac cccaacagca agcctctgac ggcgcagctg ttcctgatag 11640tgcagcacag cagggacaac gaggcgttta gggacgcgct gctgaacatc accgagcccg 11700agggtcggtg gctgctggac ctgattaaca tcctgcagag catagtggtg caggagcgca 11760gcctgagcct ggccgacaag gtggcggcca tcaactactc gatgctgagc ctgggcaagt 11820tttacgcgcg caagatctac cagacgccgt acgtgcccat agacaaggag gtgaagatcg 11880acggttttta catgcgcatg gcgctgaagg tgctcaccct gagcgacgac ctgggcgtgt 11940accgcaacga gcgcatccac aaggccgtga gcgtgagccg gcggcgcgag ctgagcgacc 12000gcgagctgat gcacagcctg cagcgggcgc tggcgggcgc cggcagcggc gacagggagg 12060cggagtccta cttcgatgcg ggggcggacc tgcgctgggc gcccagccgg cgggccctgg 12120aggccgcggg ggtccgcgag gactatgacg aggacggcga ggaggatgag gagtacgagc 12180tagaggaggg cgagtacctg gactaaaccg cgggtggtgt ttccggtaga tgcaagaccc 12240gaacgtggtg gacccggcgc tgcgggcggc tctgcagagc cagccgtccg gccttaactc 12300ctcagacgac tggcgacagg tcatggaccg catcatgtcg ctgacggcgc gtaacccgga 12360cgcgttccgg cagcagccgc aggccaacag gctctccgcc atcctggagg cggtggtgcc 12420tgcgcgctcg aaccccacgc acgagaaggt gctggccata gtgaacgcgc tggccgagaa 12480cagggccatc cgcccggacg aggccgggct ggtgtacgac gcgctgctgc agcgcgtggc 12540ccgctacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg acgtgcgcga 12600ggcggtggcg cagcgcgagc gcgcggatcg gcagggcaac ctgggctcca tggtggcgct 12660gaatgccttc ctgagcacgc agccggccaa cgtgccgcgg gggcaggaag actacaccaa 12720ctttgtgagc gcgctgcggc tgatggtgac cgagaccccc cagagcgagg tgtaccagtc 12780gggcccggac tacttcttcc agaccagcag acagggcctg cagacggtga acctgagcca 12840ggctttcaag aacctgcggg ggctgtgggg cgtgaaggcg cccaccggcg accgggcgac 12900ggtgtccagc ctgctgacgc ccaactcgcg cctgctgctg ctgctgatcg cgccgttcac 12960ggacagcggc agcgtgtccc gggacaccta cctggggcac ctgctgaccc tgtaccgcga 13020ggccatcggg caggcgcagg tggacgagca caccttccag gagatcacca gcgtgagccg 13080cgcgctgggg caggaggaca cgagcagcct ggaggcgact ctgaactacc tgctgaccaa 13140ccggcggcag aagattccct cgctgcacag cctgacctcc gaggaggagc gcatcttgcg 13200ctacgtgcag cagagcgtga gcctgaacct gatgcgcgac ggggtgacgc ccagcgtggc 13260gctggacatg accgcgcgca acatggaacc gggcatgtac gccgcgcacc ggccttacat 13320caaccgcctg atggactacc tgcatcgcgc ggcggccgtg aaccccgagt actttaccaa 13380cgccatcctg aacccgcact ggctcccgcc gcccgggttc tacagcgggg gcttcgaggt 13440cccggagacc aacgatggct tcctgtggga cgacatggac gacagcgtgt tctccccgcg 13500gccgcaggcg ctggcggaag cgtccctgct gcgtcccaag aaggaggagg aggaggaggc 13560gagtcgccgc cgcggcagca gcggcgtggc ttctctgtcc gagctggggg cggcagccgc 13620cgcgcgcccc gggtccctgg gcggcagccc ctttccgagc ctggtggggt ctctgcacag 13680cgagcgcacc acccgccctc ggctgctggg cgaggacgag tacctgaata actccctgct 13740gcagccggtg cgggagaaaa acctgcctcc cgccttcccc aacaacggga tagagagcct 13800ggtggacaag atgagcagat ggaagaccta tgcgcaggag cacagggacg cgcctgcgct 13860ccggccgccc acgcggcgcc agcgccacga ccggcagcgg gggctggtgt gggatgacga 13920ggactccgcg gacgatagca gcgtgctgga cctgggaggg agcggcaacc cgttcgcgca 13980cctgcgcccc cgcctgggga ggatgtttta aaaaaaaaaa aaaaaagcaa gaagcatgat 14040gcaaaaatta aataaaactc accaaggcca tggcgaccga gcgttggttt cttgtgttcc 14100cttcagtatg cggcgcgcgg cgatgtacca ggagggacct cctccctctt acgagagcgt 14160ggtgggcgcg gcggcggcgg cgccctcttc tccctttgcg tcgcagctgc tggagccgcc 14220gtacgtgcct ccgcgctacc tgcggcctac gggggggaga aacagcatcc gttactcgga 14280gctggcgccc ctgttcgaca ccacccgggt gtacctggtg gacaacaagt cggcggacgt 14340ggcctccctg aactaccaga acgaccacag caattttttg accacggtca tccagaacaa 14400tgactacagc ccgagcgagg ccagcaccca gaccatcaat ctggatgacc ggtcgcactg 14460gggcggcgac ctgaaaacca tcctgcacac caacatgccc aacgtgaacg agttcatgtt 14520caccaataag ttcaaggcgc gggtgatggt gtcgcgctcg cacaccaagg aagaccgggt 14580ggagctgaag tacgagtggg tggagttcga gctgccagag ggcaactact ccgagaccat 14640gaccattgac ctgatgaaca acgcgatcgt ggagcactat ctgaaagtgg gcaggcagaa 14700cggggtcctg gagagcgaca tcggggtcaa gttcgacacc aggaacttcc gcctggggct 14760ggaccccgtg accgggctgg ttatgcccgg ggtgtacacc aacgaggcct tccatcccga 14820catcatcctg ctgcccggct gcggggtgga cttcacttac agccgcctga gcaacctcct 14880gggcatccgc aagcggcagc ccttccagga gggcttcagg atcacctacg aggacctgga 14940ggggggcaac atccccgcgc tcctcgatgt ggaggcctac caggatagct tgaaggaaaa 15000tgaggcggga caggaggata ccgcccccgc cgcctccgcc gccgccgagc agggcgagga 15060tgctgctgac accgcggccg cggacggggc agaggccgac cccgctatgg tggtggaggc 15120tcccgagcag gaggaggaca tgaatgacag tgcggtgcgc ggagacacct tcgtcacccg 15180gggggaggaa aagcaagcgg aggccgaggc cgcggccgag gaaaagcaac tggcggcagc 15240agcggcggcg gcggcgttgg ccgcggcgga ggctgagtct gaggggacca agcccgccaa 15300ggagcccgtg attaagcccc tgaccgaaga tagcaagaag cgcagttaca acctgctcaa 15360ggacagcacc aacaccgcgt accgcagctg gtacctggcc tacaactacg gcgacccgtc 15420gacgggggtg cgctcctgga ccctgctgtg cacgccggac gtgacctgcg gctcggagca 15480ggtgtactgg tcgctgcccg acatgatgca agaccccgtg accttccgct ccacgcggca 15540ggtcagcaac ttcccggtgg tgggcgccga gctgctgccc gtgcactcca agagcttcta 15600caacgaccag gccgtctact cccagctcat ccgccagttc acctctctga cccacgtgtt 15660caatcgcttt cctgagaacc agattctggc gcgcccgccc gcccccacca tcaccaccgt 15720cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca acagcatcgg 15780aggagtccag cgagtgaccg ttactgacgc cagacgccgc acctgcccct acgtttacaa 15840ggccttgggc atagtctcgc cgcgcgtcct ttccagccgc actttttgag caacaccacc 15900atcatgtcca tcctgatctc acccagcaat aactccggct ggggactgct gcgcgcgccc 15960agcaagatgt tcggaggggc gaggaagcgt tccgagcagc accccgtgcg cgtgcgcggg 16020cacttccgcg ccccctgggg agcgcacaaa cgcggccgcg cggggcgcac caccgtggac 16080gacgccatcg actcggtggt ggagcaggcg cgcaactaca ggcccgcggt ctctaccgtg 16140gacgcggcca tccagaccgt ggtgcggggc gcgcggcggt acgccaagct gaagagccgc 16200cggaagcgcg tggcccgccg ccaccgccgc cgacccgggg ccgccgccaa acgcgccgcc 16260gcggccctgc ttcgccgggc caagcgcacg ggccgccgcg ccgccatgag ggccgcgcgc 16320cgcttggccg ccggcatcac cgccgccacc atggcccccc gtacccgaag acgcgcggcc 16380gccgccgccg ccgccgccat cagtgacatg gccagcaggc gccggggcaa cgtgtactgg 16440gtgcgcgact cggtgaccgg cacgcgcgtg cccgtgcgct tccgcccccc gcggacttga 16500gatgatgtga aaaaacaaca ctgagtctcc tgctgttgtg tgtatcccag cggcggcggc 16560gcgcgcagcg tcatgtccaa gcgcaaaatc aaagaagaga tgctccaggt cgtcgcgccg 16620gagatctatg ggcccccgaa gaaggaagag caggattcga agccccgcaa gataaagcgg 16680gtcaaaaaga aaaagaaaga tgatgacgat gccgatgggg aggtggagtt cctgcgcgcc 16740acggcgccca ggcgcccggt gcagtggaag ggccggcgcg taaagcgcgt cctgcgcccc 16800ggcaccgcgg tggtcttcac gcccggcgag cgctccaccc ggactttcaa gcgcgtctat 16860gacgaggtgt acggcgacga agacctgctg gagcaggcca acgagcgctt cggagagttt 16920gcttacggga agcgtcagcg ggcgctgggg aaggaggacc tgctggcgct gccgctggac 16980cagggcaacc ccacccccag tctgaagccc gtgaccctgc agcaggtgct gccgagcagc 17040gcaccctccg aggcgaagcg gggtctgaag cgcgagggcg gcgacctggc gcccaccgtg 17100cagctcatgg tgcccaagcg gcagaggctg gaggatgtgc tggagaaaat gaaagtagac 17160cccggtctgc agccggacat cagggtccgc cccatcaagc aggtggcgcc gggcctcggc 17220gtgcagaccg tggacgtggt catccccacc ggcaactccc ccgccgccgc caccactacc 17280gctgcctcca cggacatgga gacacagacc gatcccgccg cagccgcagc cgcagccgcc 17340gccgcgacct cctcggcgga ggtgcagacg gacccctggc tgccgccggc gatgtcagct 17400ccccgcgcgc gtcgcgggcg caggaagtac ggcgccgcca acgcgctcct gcccgagtac 17460gccttgcatc cttccatcgc gcccaccccc ggctaccgag gctataccta ccgcccgcga 17520agagccaagg gttccacccg ccgtccccgc cgacgcgccg ccgccaccac ccgccgccgc 17580cgccgcagac gccagcccgc actggctcca gtctccgtga ggaaagtggc gcgcgacgga 17640cacaccctgg tgctgcccag ggcgcgctac caccccagca tcgtttaaaa gcctgttgtg 17700gttcttgcag atatggccct cacttgccgc ctccgtttcc cggtgccggg ataccgagga 17760ggaagatcgc gccgcaggag gggtctggcc ggccgcggcc tgagcggagg cagccgccgc 17820gcgcaccggc ggcgacgcgc caccagccga cgcatgcgcg gcggggtgct gcccctgtta 17880atccccctga tcgccgcggc gatcggcgcc gtgcccggga tcgcctccgt ggccttgcaa 17940gcgtcccaga ggcattgaca gacttgcaaa cttgcaaata tggaaaaaaa aaccccaata 18000aaaaagtcta gactctcacg ctcgcttggt cctgtgacta ttttgtagaa tggaagacat 18060caactttgcg tcgctggccc cgcgtcacgg ctcgcgcccg ttcctgggac actggaacga 18120tatcggcacc agcaacatga gcggtggcgc cttcagttgg ggctctctgt ggagcggcat 18180taaaagtatc gggtctgccg ttaaaaatta cggctcccgg gcctggaaca gcagcacggg 18240ccagatgttg agagacaagt tgaaagagca gaacttccag cagaaggtgg tggagggcct 18300ggcctccggc atcaacgggg tggtggacct ggccaaccag gccgtgcaga ataagatcaa 18360cagcagactg gacccccggc cgccggtgga ggaggtgccg ccggcgctgg agacggtgtc 18420ccccgatggg cgtggcgaga agcgcccgcg gcccgatagg gaagagacca ctctggtcac 18480gcagaccgat gagccgcccc cgtatgagga ggccctgaag caaggtctgc ccaccacgcg 18540gcccatcgcg cccatggcca ccggggtggt gggccgccac acccccgcca cgctggactt 18600gcctccgccc gccgatgtgc cgcagcagca gaaggcggca cagccgggcc cgcccgcgac 18660cgcctcccgt tcctccgccg gtcctctgcg ccgcgcggcc agcggccccc gcgggggggt 18720cgcgaggcac ggcaactggc agagcacgct gaacagcatc gtgggtctgg gggtgcggtc 18780cgtgaagcgc cgccgatgct actgaatagc ttagctaacg tgttgtatgt gtgtatgcgc 18840cctatgtcgc cgccagagga gctgctgagt cgccgccgtt cgcgcgccca ccaccaccgc 18900cactccgccc ctcaagatgg cgaccccatc gatgatgccg cagtggtcgt acatgcacat 18960ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagttcg cccgcgccac 19020cgagagctac ttcagcctga gtaacaagtt taggaacccc acggtggcgc ccacgcacga 19080tgtgaccacc gaccggtctc agcgcctgac gctgcggttc attcccgtgg accgcgagga 19140caccgcgtac tcgtacaagg cgcggttcac cctggccgtg ggcgacaacc gcgtgctgga 19200catggcctcc acctactttg acatccgcgg ggtgctggac cggggtccca ctttcaagcc 19260ctactctggc accgcctaca actccctggc ccccaagggc gctcccaact cctgcgagtg 19320ggagcaagag gaaactcagg cagttgaaga agcagcagaa gaggaagaag aagatgctga 19380cggtcaagct gaggaagagc aagcagctac caaaaagact catgtatatg ctcaggctcc 19440cctttctggc gaaaaaatta gtaaagatgg tctgcaaata ggaacggacg ctacagctac 19500agaacaaaaa cctatttatg cagaccctac attccagccc gaaccccaaa tcggggagtc 19560ccagtggaat gaggcagatg ctacagtcgc cggcggtaga gtgctaaaga aatctactcc 19620catgaaacca tgctatggtt cctatgcaag acccacaaat gctaatggag gtcagggtgt 19680actaacggca aatgcccagg gacagctaga atctcaggtt gaaatgcaat tcttttcaac 19740ttctgaaaac gcccgtaacg aggctaacaa cattcagccc aaattggtgc tgtatagtga 19800ggatgtgcac atggagaccc cggatacgca cctttcttac aagcccgcaa aaagcgatga 19860caattcaaaa atcatgctgg gtcagcagtc catgcccaac agacctaatt acatcggctt 19920cagagacaac tttatcggcc tcatgtatta caatagcact ggcaacatgg gagtgcttgc 19980aggtcaggcc tctcagttga atgcagtggt ggacttgcaa gacagaaaca cagaactgtc 20040ctaccagctc ttgcttgatt ccatgggtga cagaaccaga tacttttcca tgtggaatca 20100ggcagtggac agttatgacc cagatgttag aattattgaa aatcatggaa ctgaagacga 20160gctccccaac tattgtttcc ctctgggtgg cataggggta actgacactt accaggctgt 20220taaaaccaac aatggcaata acgggggcca ggtgacttgg acaaaagatg aaacttttgc 20280agatcgcaat gaaatagggg tgggaaacaa tttcgctatg gagatcaacc tcagtgccaa 20340cctgtggaga aacttcctgt actccaacgt ggcgctgtac ctaccagaca agcttaagta 20400caacccctcc aatgtggaca tctctgacaa ccccaacacc tacgattaca tgaacaagcg 20460agtggtggcc ccggggctgg tggactgcta catcaacctg ggcgcgcgct ggtcgctgga 20520ctacatggac aacgtcaacc ccttcaacca ccaccgcaat gcgggcctgc gctaccgctc 20580catgctcctg ggcaacgggc gctacgtgcc cttccacatc caggtgcccc agaagttctt 20640tgccatcaag aacctcctcc tcctgccggg ctcctacacc tacgagtgga acttcaggaa 20700ggatgtcaac atggtcctcc agagctctct gggtaacgat ctcagggtgg acggggccag 20760catcaagttc gagagcatct gcctctacgc caccttcttc cccatggccc acaacacggc 20820ctccacgctc gaggccatgc tcaggaacga caccaacgac cagtccttca atgactacct 20880ctccgccgcc aacatgctct accccatacc cgccaacgcc accaacgtcc ccatctccat 20940cccctcgcgc aactgggcgg ccttccgcgg ctgggccttc acccgcctca agaccaagga 21000gaccccctcc ctgggctcgg gattcgaccc ctactacacc tactcgggct ccattcccta 21060cctggacggc accttctacc tcaaccacac tttcaagaag gtctcggtca ccttcgactc 21120ctcggtcagc tggccgggca acgaccgtct gctcaccccc aacgagttcg agatcaagcg 21180ctcggtcgac ggggagggct acaacgtggc ccagtgcaac atgaccaagg actggttcct 21240ggtccagatg ctggccaact acaacatcgg ctaccagggc ttctacatcc cagagagcta 21300caaggacagg atgtactcct tcttcaggaa cttccagccc atgagccggc aggtggtgga 21360ccagaccaag tacaaggact accaggaggt gggcatcatc caccagcaca acaactcggg 21420cttcgtgggc tacctcgccc ccaccatgcg cgagggacag gcctaccccg ccaacttccc 21480ctatccgctc ataggcaaga ccgcggtcga cagcatcacc cagaaaaagt tcctctgcga 21540ccgcaccctc tggcgcatcc ccttctccag caacttcatg tccatgggtg cgctctcgga 21600cctgggccag aacttgctct acgccaactc cgcccacgcc ctcgacatga ccttcgaggt 21660cgaccccatg gacgagccca cccttctcta tgttctgttc gaagtctttg acgtggtccg 21720ggtccaccag ccgcaccgcg gcgtcatcga gaccgtgtac ctgcgtacgc ccttctcggc 21780cggcaacgcc accacctaaa gaagcaagcc gcagtcatcg ccgcctgcat gccgtcgggt 21840tccaccgagc aagagctcag ggccatcgtc agagacctgg gatgcgggcc ctattttttg 21900ggcaccttcg acaagcgctt ccctggcttt gtctccccac acaagctggc ctgcgccatc 21960gtcaacacgg ccggccgcga gaccgggggc gtgcactggc tggccttcgc ctggaacccg 22020cgctccaaaa catgcttcct ctttgacccc ttcggctttt cggaccagcg gctcaagcaa 22080atctacgagt tcgagtacga gggcttgctg cgtcgcagcg ccatcgcctc ctcgcccgac 22140cgctgcgtca ccctcgaaaa gtccacccag accgtgcagg ggcccgactc ggccgcctgc 22200ggtctcttct gctgcatgtt tctgcacgcc tttgtgcact ggcctcagag tcccatggac 22260cgcaacccca ccatgaactt gctgacgggg gtgcccaact ccatgctcca gagcccccag 22320gtcgagccca ccctgcgccg caaccaggag cagctctaca gcttcctgga gcgccactcg 22380ccttacttcc gccgccacag cgcacagatc aggagggcca cctccttctg ccacttgcaa 22440gagatgcaag aagggtaata acgatgtaca cacttttttt ctcaataaat ggcatctttt 22500tatttataca agctctctgg ggtattcatt tcccaccacc acccgccgtt gtcgccatct 22560ggctctattt agaaatcgaa agggttctgc cgggagtcgc cgtgcgccac gggcagggac 22620acgttgcgat actggtagcg ggtgccccac ttgaactcgg gcaccaccag gcgaggcagc 22680tcggggaagt tttcgctcca caggctgcgg gtcagcacca gcgcgttcat caggtcgggc 22740gccgagatct tgaagtcgca gttggggccg ccgccctgcg cgcgcgagtt gcggtacacc 22800gggttgcagc actggaacac caacagcgcc gggtgcttca cgctggccag cacgctgcgg 22860tcggagatca gctcggcgtc caggtcctcc gcgttgctca gcgcgaacgg ggtcatcttg 22920ggcacttgcc gccccaggaa gggcgcgtgc cccggtttcg agttgcagtc gcagcgcagc 22980gggatcagca ggtgcccgtg cccggactcg gcgttggggt acagcgcgcg catgaaggcc 23040tgcatctggc ggaaggccat ctgggccttg gcgccctccg agaagaacat gccgcaggac 23100ttgcccgaga actggtttgc ggggcagctg gcgtcgtgca ggcagcagcg cgcgtcggtg 23160ttggcgatct gcaccacgtt gcgcccccac cggttcttca cgatcttggc cttggacgat 23220tgctccttca gcgcgcgctg cccgttctcg ctggtcacat ccatctcgat cacatgttcc 23280ttgttcacca tgctgctgcc gtgcagacac ttcagctcgc cctccgtctc ggtgcagcgg 23340tgctgccaca gcgcgcagcc cgtgggctcg aaagacttgt aggtcacctc cgcgaaggac 23400tgcaggtacc cctgcaaaaa gcggcccatc atggtcacga aggtcttgtt gctgctgaag 23460gtcagctgca gcccgcggtg ctcctcgttc agccaggtct tgcacacggc cgccagcgcc 23520tccacctggt cgggcagcat cttgaagttc accttcagct cattctccac gtggtacttg 23580tccatcagcg tgcgcgccgc ctccatgccc ttctcccagg ccgacaccag cggcaggctc 23640acggggttct tcaccatcac cgtggccgcc gcctccgccg cgctttcgct ttccgccccg 23700ctgttctctt cctcttcctc ctcttcctcg ccgccgccca ctcgcagccc ccgcaccacg 23760gggtcgtctt cctgcaggcg ctgcaccttg cgcttgccgt tgcgcccctg cttgatgcgc 23820acgggcgggt tgctgaagcc caccatcacc agcgcggcct cttcttgctc gtcctcgctg 23880tccagaatga cctccgggga gggggggttg gtcatcctca gtaccgaggc acgcttcttt 23940ttcttcctgg gggcgttcgc cagctccgcg gctgcggccg ctgccgaggt cgaaggccga 24000gggctgggcg tgcgcggcac cagcgcgtcc tgcgagccgt cctcgtcctc ctcggactcg 24060agacggaggc gggcccgctt cttcgggggc gcgcggggcg gcggaggcgg cggcggcgac 24120ggagacgggg acgagacatc gtccagggtg ggtggacggc gggccgcgcc gcgtccgcgc 24180tcgggggtgg tctcgcgctg gtcctcttcc cgactggcca tctcccactg ctccttctcc 24240tataggcaga aagagatcat ggagtctctc atgcgagtcg agaaggagga ggacagccta 24300accgccccct ctgagccctc caccaccgcc gccaccaccg ccaatgccgc cgcggacgac 24360gcgcccaccg agaccaccgc cagtaccacc ctccccagcg acgcaccccc gctcgagaat 24420gaagtgctga tcgagcagga cccgggtttt gtgagcggag aggaggatga ggtggatgag 24480aaggagaagg aggaggtcgc cgcctcagtg ccaaaagagg ataaaaagca agaccaggac 24540gacgcagata aggatgagac agcagtcggg cgggggaacg gaagccatga tgctgatgac 24600ggctacctag acgtgggaga cgacgtgctg cttaagcacc tgcaccgcca gtgcgtcatc 24660gtctgcgacg cgctgcagga gcgctgcgaa gtgcccctgg acgtggcgga ggtcagccgc 24720gcctacgagc ggcacctctt cgcgccgcac gtgcccccca agcgccggga gaacggcacc 24780tgcgagccca acccgcgtct caacttctac ccggtcttcg cggtacccga ggtgctggcc 24840acctaccaca tctttttcca aaactgcaag atccccctct cctgccgcgc caaccgcacc 24900cgcgccgaca aaaccctgac cctgcggcag ggcgcccaca tacctgatat cgcctctctg 24960gaggaagtgc ccaagatctt cgagggtctc ggtcgcgacg agaaacgggc ggcgaacgct 25020ctgcacggag acagcgaaaa cgagagtcac tcgggggtgc tggtggagct cgagggcgac 25080aacgcgcgcc tggccgtact caagcgcagc atagaggtca cccactttgc ctacccggcg 25140ctcaacctgc cccccaaggt catgagtgtg gtcatgggcg agctcatcat gcgccgcgcc 25200cagcccctgg ccgcggatgc aaacttgcaa gagtcctccg aggaaggcct gcccgcggtc 25260agcgacgagc agctggcgcg ctggctggag acccgcgacc ccgcgcagct ggaggagcgg 25320cgcaagctca tgatggccgc ggtgctggtc accgtggagc tcgagtgtct gcagcgcttc 25380ttcgcggacc ccgagatgca gcgcaagctc gaggagaccc tgcactacac cttccgccag 25440ggctacgtgc gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac 25500ctgggcatcc tgcacgagaa ccgcctcggg cagaacgtcc tgcactccac cctcaaaggg 25560gaggcgcgcc gcgactacat ccgcgactgc gcctacctct tcctctgcta cacctggcag

25620acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga gctggaaaag 25680ctcctcaagc gcaccctcag ggacctctgg acgggcttca acgagcgctc ggtggccgcc 25740gcgctggcgg acatcatctt tcccgagcgc ctgctcaaga ccctgcagca gggcctgccc 25800gacttcacca gccagagcat gctgcagaac ttcaggactt tcatcctgga gcgctcgggc 25860atcctgccgg ccacttgctg cgcgctgccc agcgacttcg tgcccatcaa gtacagggag 25920tgcccgccgc cgctctgggg ccactgctac ctcttccagc tggccaacta cctcgcctac 25980cactcggacc tcatggaaga cgtgagcggc gagggcctgc tcgagtgcca ctgccgctgc 26040aacctctgca cgccccaccg ctctctagtc tgcaacccgc agctgctcag cgagagtcag 26100attatcggta ccttcgagct gcagggtccc tcgcctgacg agaagtccgc ggctccaggg 26160ctgaaactca ctccggggct gtggacttcc gcctacctac gcaaatttgt acctgaggac 26220taccacgccc acgagatcag gttctacgaa gaccaatccc gcccgcccaa ggcggagctc 26280accgcctgcg tcatcaccca ggggcacatc ctgggccaat tgcaagccat caacaaagcc 26340cgccgagagt tcttgctgaa aaagggtcgg ggggtgtacc tggaccccca gtccggcgag 26400gagctaaacc cgctaccccc gccgccgccc cagcagcggg accttgcttc ccaggatggc 26460acccagaaag aagcagcagc cgccgccgcc gccgcagcca tacatgcttc tggaggaaga 26520ggaggaggac tgggacagtc aggcagagga ggtttcggac gaggagcagg aggagatgat 26580ggaagactgg gaggaggaca gcagcctaga cgaggaagct tcagaggccg aagaggtggc 26640agacgcaaca ccatcgccct cggtcgcagc cccctcgccg gggcccctga aatcctccga 26700acccagcacc agcgctataa cctccgctcc tccggcgccg gcgccacccg cccgcagacc 26760caaccgtaga tgggacacca caggaaccgg ggtcggtaag tccaagtgcc cgccgccgcc 26820accgcagcag cagcagcagc agcgccaggg ctaccgctcg tggcgcgggc acaagaacgc 26880catagtcgcc tgcttgcaag actgcggggg caacatctct ttcgcccgcc gcttcctgct 26940attccaccac ggggtcgcct ttccccgcaa tgtcctgcat tactaccgtc atctctacag 27000cccctactgc agcggcgacc cagaggcggc agcggcagcc acagcggcga ccaccaccta 27060ggaagatatc ctccgcgggc aagacagcgg cagcagcggc caggagaccc gcggcagcag 27120cggcgggagc ggtgggcgca ctgcgcctct cgcccaacga acccctctcg acccgggagc 27180tcagacacag gatcttcccc actttgtatg ccatcttcca acagagcaga ggccaggagc 27240aggagctgaa aataaaaaac agatctctgc gctccctcac ccgcagctgt ctgtatcaca 27300aaagcgaaga tcagcttcgg cgcacgctgg aggacgcgga ggcactcttc agcaaatact 27360gcgcgctcac tcttaaagac tagctccgcg cccttctcga atttaggcgg gagaaaacta 27420cgtcatcgcc ggccgccgcc cagcccgccc agccgagatg agcaaagaga ttcccacgcc 27480atacatgtgg agctaccagc cgcagatggg actcgcggcg ggagcggccc aggactactc 27540cacccgcatg aactacatga gcgcgggacc ccacatgatc tcacaggtca acgggatccg 27600cgcccagcga aaccaaatac tgctggaaca ggcggccatc accgccacgc cccgccataa 27660tctcaacccc cgaaattggc ccgccgccct cgtgtaccag gaaaccccct ccgccaccac 27720cgtactactt ccgcgtgacg cccaggccga agtccagatg actaactcag gggcgcagct 27780cgcgggcggc tttcgtcacg gggcgcggcc gctccgacca ggtataagac acctgatgat 27840cagaggccga ggtatccagc tcaacgacga gtcggtgagc tcttcgctcg gtctccgtcc 27900ggacggaact ttccagctcg ccggatccgg ccgctcttcg ttcacgcccc gccaggcgta 27960cctgactctg cagacctcgt cctcggagcc ccgctccggc ggcatcggaa ccctccagtt 28020cgtggaggag ttcgtgccct cggtctactt caaccccttc tcgggacctc ccggacgcta 28080ccccgaccag ttcattccga actttgacgc ggtgaaggac tcggcggacg gctacgactg 28140aatgtcaggt gtcgaggcag agcagcttcg cctgagacac ctcgagcact gccgccgcca 28200caagtgcttc gcccgcggtt ctggtgagtt ctgctacttt cagctacccg aggagcatac 28260cgaggggccg gcgcacggcg tccgcctgac cacccagggc gaggttacct gttccctcat 28320ccgggagttt accctccgtc ccctgctagt ggagcgggag cggggtccct gtgtcctaac 28380tatcgcctgc aactgcccta accctggatt acatcaagat ctttgctgtc atctctgtgc 28440tgagtttaat aaacgctgag atcagaatct actggggctc ctgtcgccat cctgtgaacg 28500ccaccgtctt cacccacccc gaccaggccc aggcgaacct cacctgcggt ctgcatcgga 28560gggccaagaa gtacctcacc tggtacttca acggcacccc ctttgtggtt tacaacagct 28620tcgacgggga cggagtctcc ctgaaagacc agctctccgg tctcagctac tccatccaca 28680agaacaccac cctccaactc ttccctccct acctgccggg aacctacgag tgcgtcaccg 28740gccgctgcac ccacctcacc cgcctgatcg taaaccagag ctttccggga acagataact 28800ccctcttccc cagaacagga ggtgagctca ggaaactccc cggggaccag ggcggagacg 28860taccttcgac ccttgtgggg ttaggatttt ttattaccgg gttgctggct cttttaatca 28920aagtttcctt gagatttgtt ctttccttct acgtgtatga acacctcaac ctccaataac 28980tctacccttt cttcggaatc aggtgacttc tctgaaatcg ggcttggtgt gctgcttact 29040ctgttgattt ttttccttat catactcagc cttctgtgcc tcaggctcgc cgcctgctgc 29100gcacacatct atatctactg ctggttgctc aagtgcaggg gtcgccaccc aagatgaaca 29160ggtacatggt cctatcgatc ctaggcctgc tggccctggc ggcctgcagc gccgccaaaa 29220aagagattac ctttgaggag cccgcttgca atgtaacttt caagcccgag ggtgaccaat 29280gcaccaccct cgtcaaatgc gttaccaatc atgagaggct gcgcatcgac tacaaaaaca 29340aaactggcca gtttgcggtc tatagtgtgt ttacgcccgg agacccctct aactactctg 29400tcaccgtctt ccagggcgga cagtctaaga tattcaatta cactttccct ttttatgagt 29460tatgcgatgc ggtcatgtac atgtcaaaac agtacaacct gtggcctccc tctccccagg 29520cgtgtgtgga aaatactggg tcttactgct gtatggcttt cgcaatcact acgctcgctc 29580taatctgcac ggtgctatac ataaaattca ggcagaggcg aatctttatc gatgaaaaga 29640aaatgccttg atcgctaaca ccggctttct atctgcagaa tgaatgcaat cacctcccta 29700ctaatcacca ccaccctcct tgcgattgcc catgggttga cacgaatcga agtgccagtg 29760gggtccaatg tcaccatggt gggccccgcc ggcaattcca ccctcatgtg ggaaaaattt 29820gtccgcaatc aatgggttca tttctgctct aaccgaatca gtatcaagcc cagagccatc 29880tgcgatgggc aaaatctaac tctgatcaat gtgcaaatga tggatgctgg gtactattac 29940gggcagcggg gagaaatcat taattactgg cgaccccaca aggactacat gctgcatgta 30000gtcgaggcac ttcccactac cacccccact accacctctc ccaccaccac caccactact 30060actactacta ctactactac tactactacc actaccgctg cccgccatac ccgcaaaagc 30120accatgatta gcacaaagcc ccctcgtgct cactcccacg ccggcgggcc catcggtgcg 30180acctcagaaa ccaccgagct ttgcttctgc caatgcacta acgccagcgc tcatgaactg 30240ttcgacctgg agaatgagga tgtccagcag agctccgctt gcctgaccca ggaggctgtg 30300gagcccgttg ccctgaagca gatcggtgat tcaataattg actcttcttc ttttgccact 30360cccgaatacc ctcccgattc tactttccac atcacgggta ccaaagaccc taacctctct 30420ttctacctga tgctgctgct ctgtatctct gtggtctctt ccgcgctgat gttactgggg 30480atgttctgct gcctgatctg ccgcagaaag agaaaagctc gctctcaggg ccaaccactg 30540atgcccttcc cctacccccc ggattttgca gataacaaga tatgagctcg ctgctgacac 30600taaccgcttt actagcctgc gctctaaccc ttgtcgcttg cgactcgaga ttccacaatg 30660tcacagctgt ggcaggagaa aatgttactt tcaactccac ggccgatacc cagtggtcgt 30720ggagtggctc aggtagctac ttaactatct gcaatagctc cacttccccc ggcatatccc 30780caaccaagta ccaatgcaat gccagcctgt tcaccctcat caacgcttcc accctggaca 30840atggactcta tgtaggctat gtaccctttg gtgggcaagg aaagacccac gcttacaacc 30900tggaagttcg ccagcccaga accactaccc aagcttctcc caccaccacc accaccacca 30960ccatcaccag cagcagcagc agcagcagcc acagcagcag cagcagatta ttgactttgg 31020ttttggccag ctcatctgcc gctacccagg ccatctacag ctctgtgccc gaaaccactc 31080agatccaccg cccagaaacg accaccgcca ccaccctaca cacctccagc gatcagatgc 31140cgaccaacat cacccccttg gctcttcaaa tgggacttac aagccccact ccaaaaccag 31200tggatgcggc cgaggtctcc gccctcgtca atgactgggc ggggctggga atgtggtggt 31260tcgccatagg catgatggcg ctctgcctgc ttctgctctg gctcatctgc tgcctccacc 31320gcaggcgagc cagacccccc atctatagac ccatcattgt cctgaacccc gataatgatg 31380ggatccatag attggatggc ctgaaaaacc tacttttttc ttttacagta tgataaattg 31440agacatgcct cgcattttct tgtacatgtt ccttctccca ccttttctgg ggtgttctac 31500gctggccgct gtgtctcacc tggaggtaga ctgcctctca cccttcactg tctacctgct 31560ttacggattg gtcaccctca ctctcatctg cagcctaatc acagtaatca tcgccttcat 31620ccagtgcatt gattacatct gtgtgcgcct cgcatacttc agacaccacc cgcagtaccg 31680agacaggaac attgcccaac ttctaagact gctctaatca tgcataagac tgtgatctgc 31740cttctgatcc tctgcatcct gcccaccctc acctcctgcc agtacaccac aaaatctccg 31800cgcaaaagac atgcctcctg ccgcttcacc caactgtgga atatacccaa atgctacaac 31860gaaaagagcg agctctccga agcttggctg tatggggtca tctgtgtctt agttttctgc 31920agcactgtct ttgccctcat aatctacccc tactttgatt tgggatggaa cgcgatcgat 31980gccatgaatt accccacctt tcccgcaccc gagataattc cactgcgaca agttgtaccc 32040gttgtcgtta atcaacgccc cccatcccct acgcccactg aaatcagcta ctttaaccta 32100acaggcggag atgactgacg ccctagatct agaaatggac ggcatcagta ccgagcagcg 32160tctcctagag aggcgcaggc aggcggctga gcaagagcgc ctcaatcagg agctccgaga 32220tctcgttaac ctgcaccagt gcaaaagagg catcttttgt ctggtaaagc aggccaaagt 32280cacctacgag aagaccggca acagccaccg cctcagttac aaattgccca cccagcgcca 32340gaagctggtg ctcatggtgg gtgagaatcc catcaccgtc acccagcact cggtagagac 32400cgaggggtgt ctgcactccc cctgtcgggg tccagaagac ctctgcaccc tggtaaagac 32460cctgtgcggt ctcagagatt tagtcccctt taactaatca aacactggaa tcaataaaaa 32520gaatcactta cttaaaatca gacagcaggt ctctgtccag tttattcagc agcacctcct 32580tcccctcctc ccaactctgg tactccaaac gccttctggc ggcaaacttc ctccacaccc 32640tgaagggaat gtcagattct tgctcctgtc cctccgcacc cactatcttc atgttgttgc 32700agatgaagcg caccaaaacg tctgacgaga gcttcaaccc cgtgtacccc tatgacacgg 32760aaagcggccc tccctccgtc cctttcctca cccctccctt cgtgtctccc gatggattcc 32820aagaaagtcc ccccggggtc ctgtctctga acctggccga gcccctggtc acttcccacg 32880gcatgctcgc cctgaaaatg ggaagtggcc tctccctgga cgacgctggc aacctcacct 32940ctcaagatat caccaccgct agccctcccc tcaaaaaaac caagaccaac ctcagcctag 33000aaacctcatc ccccctaact gtgagcacct caggcgccct caccgtagca gccgccgctc 33060ccctggcggt ggccggcacc tccctcacca tgcaatcaga ggcccccctg acagtacagg 33120atgcaaaact caccctggcc accaaaggcc ccctgaccgt gtctgaaggc aaactggcct 33180tgcaaacatc ggccccgctg acggccgctg acagcagcac cctcacagtc agtgccacac 33240caccccttag cacaagcaat ggcagcttgg gtattgacat gcaagccccc atttacacca 33300ccaatggaaa actaggactt aactttggcg ctcccctgca tgtggtagac agcctaaatg 33360cactgactgt agttactggc caaggtctta cgataaacgg aacagcccta caaactagag 33420tctcaggtgc cctcaactat gacacatcag gaaacctaga attgagagct gcagggggta 33480tgcgagttga tgcaaatggt caacttatcc ttgatgtagc ttacccattt gatgcacaaa 33540acaatctcag ccttaggctt ggacagggac ccctgtttgt taactctgcc cacaacttgg 33600atgttaacta caacagaggc ctctacctgt tcacatctgg aaataccaaa aagctagaag 33660ttaatatcaa aacagccaag ggtctcattt atgatgacac tgctatagca atcaatgcgg 33720gtgatgggct acagtttgac tcaggctcag atacaaatcc attaaaaact aaacttggat 33780taggactgga ttatgactcc agcagagcca taattgctaa actgggaact ggcctaagct 33840ttgacaacac aggtgccatc acagtaggca acaaaaatga tgacaagctt accttgtgga 33900ccacaccaga cccatcccct aactgtagaa tctattcaga gaaagatgct aaattcacac 33960ttgttttgac taaatgcggc agtcaggtgt tggccagcgt ttctgtttta tctgtaaaag 34020gtagccttgc gcccatcagt ggcacagtaa ctagtgctca gattgtcctc agatttgatg 34080aaaatggagt tctactaagc aattcttccc ttgaccctca atactggaac tacagaaaag 34140gtgaccttac agagggcact gcatatacca acgcagtggg atttatgccc aacctcacag 34200catacccaaa aacacagagc caaactgcta aaagcaacat tgtaagtcag gtttacttga 34260atggggacaa atccaaaccc atgaccctca ccattaccct caatggaact aatgaaacag 34320gagatgccac agtaagcact tactccatgt cattctcatg gaactggaat ggaagtaatt 34380acattaatga aacgttccaa accaactcct tcaccttctc ctacatcgcc caagaataaa 34440aagcatgacg ctgttgattt gattcaatgt gtttctgttt tattttcaag cacaacaaaa 34500tcattcaagt cattcttcca tcttagctta atagacacag tagcttaata gacccagtag 34560tgcaaagccc cattctagct tataactagt ggagaagtac tcgcctacat gggggtagag 34620tcataatcgt gcatcaggat agggcggtgg tgctgcagca gcgcgcgaat aaactgctgc 34680cgccgccgct ccgtcctgca ggaatacaac atggcagtgg tctcctcagc gatgattcgc 34740accgcccgca gcataaggcg ccttgtcctc cgggcacagc agcgcaccct gatctcactt 34800aaatcagcac agtaactgca gcacagcacc acaatattgt tcaaaatccc acagtgcaag 34860gcgctgtatc caaagctcat ggcggggacc acagaaccca cgtggccatc ataccacaag 34920cgcaggtaga ttaagtggcg acccctcata aacacgctgg acataaacat tacctctttt 34980ggcatgttgt aattcaccac ctcccggtac catataaacc tctgattaaa catggcgcca 35040tccaccacca tcctaaacca gctggccaaa acctgcccgc cggctataca ctgcagggaa 35100ccgggactgg aacaatgaca gtggagagcc caggactcgt aaccatggat catcatgctc 35160gtcatgatat caatgttggc acaacacagg cacacgtgca tacacttcct caggattaca 35220agctcctccc gcgttagaac catatcccag ggaacaaccc attcctgaat cagcgtaaat 35280cccacactgc agggaagacc tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat 35340tcgggcagca gcggatgatc ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt 35400agacgatccc tactgtacgg agtgcgccga gacaaccgag atcgtgttgg tcgtagtgtc 35460atgccaaatg gaacgccgga cgtagtcata tttcctgaag tcttagatct ctcaacgcag 35520caccagcacc aacacttcgc agtgtaaaag gccaagtgcc gagagagtat atataggaat 35580aaaaagtgac gtaaacgggc aaagtccaaa aaacgcccag aaaaaccgca cgcgaaccta 35640cgccccgaaa cgaaagccaa aaaacactag acactccctt ccggcgtcaa cttccgcttt 35700cccacgctac gtcacttgcc ccagtcaaac aaactacata tcccgaactt ccaagtcgcc 35760acgcccaaaa caccgcctac acctccccgc ccgccggccc gcccccaaac ccgcctcccg 35820ccccgcgccc cgccccgcgc cgcccatctc attatcatat tggcttcaat ccaaaataag 35880gtatattatt gatgatggtt taaacggatc caattcttga agacgaaagg gcctcgtgat 35940acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac 36000ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 36060gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 36120tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 36180tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 36240acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 36300cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 36360ccgtgttgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 36420ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 36480atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 36540cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 36600tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 36660gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 36720ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 36780ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 36840tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 36900cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 36960ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 37020tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt 37080gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 37140cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 37200gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 37260gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac 37320tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 37380ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 37440cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 37500gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag 37560gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 37620gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 37680cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 37740tttttacggt tcctggcctt ttgctggcct tgaagctgtc cctgatggtc gtcatctacc 37800tgcctggaca gcatggcctg caacgcgggc atcccgatgc cgccggaagc gagaagaatc 37860ataatgggga aggccatcca gcctcgcgtc gcagatccga attcgtttaa ac 37912843428DNASimian adenovirus 8catcatcaat aatatacctt attttggatt gaagccaata tgataatgag atgggcggcg 60cggggcgggg cgcggggcgg gaggcgggtt tgggggcggg ccggcgggcg gggcggtgtg 120gcggaagtgg actttgtaag tgtggcggat gtgacttgct agtgccgggc gcggtaaaag 180tgacgttttc cgtgcgcgac aacgcccccg ggaagtgaca tttttcccgc ggtttttacc 240ggatgttgta gtgaatttgg gcgtaaccaa gtaagatttg gccattttcg cgggaaaact 300gaaacgggga agtgaaatct gattaatttt gcgttagtca taccgcgtaa tatttgtcta 360gggccgaggg actttggccg attacgtgga ggactcgccc aggtgttttt tgaggtgaat 420ttccgcgttc cgggtcaaag tctgcgtttt attattatag gatatcccat tgcatacgtt 480gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg 540acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 600atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 660cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 720tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 780agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 840gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 900agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 960gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 1020gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 1080gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag 1140agatctccct atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc 1200ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct 1260ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg agatcttccg 1320tttatctagg taccgggccc cccctcgagg tcgacggtat cgataagctt cacgctgccg 1380caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag ccagtccgca 1440gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc 1500aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc 1560ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg 1620gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat ggcgcagggg 1680atcaagatct aaccaggagc tatttaatgg caacagttaa ccagctggta cgcaaaccac 1740gtgctcgcaa agttgcgaaa agcaacgtgc ctgcgctgga agcatgcccg caaaaacgtg 1800gcgtatgtac tcgtgtatat actaccactc ctaaaaaacc gaactccgcg ctgcgtaaag 1860tatgccgtgt tcgtctgact aacggtttcg aagtgacttc ctacatcggt ggtgaaggtc 1920acaacctgca ggagcactcc gtgatcctga tccgtggcgg tcgtgttaaa gacctcccgg 1980gtgttcgtta ccacaccgta cgtggtgcgc ttgactgctc cggcgttaaa gaccgtaagc 2040aggctcgttc caagtatggc gtgaagcgtc ctaaggctta atggtagatc tgatcaagag 2100acaggatgac ggtcgtttcg catgcttgaa caagatggat tgcacgcagg ttctccggcc 2160gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat 2220gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg 2280tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg 2340ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta 2400ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta 2460tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc 2520gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc 2580gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg 2640ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg 2700ccgaatatca tggtggaaaa tggccgcttt

tctggattca tcgactgtgg ccggctgggt 2760gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc 2820ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc 2880atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga 2940ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg 3000aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg 3060atctcatgct ggagttcttc gcccaccccg ggctcgatcc cctcgggggg aatcagaatt 3120cagtcgacag cggccgcgat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc 3180ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 3240tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 3300gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg 3360ctctatggcc gatcagcgat cgctgaggtg ggtgagtggg cgtggcctgg ggtggtcatg 3420aaaatatata agttgggggt cttagggtct ctttatttgt gttgcagaga ccgccggagc 3480catgagcggg agcagcagca gcagcagtag cagcagcgcc ttggatggca gcatcgtgag 3540cccttatttg acgacgcgga tgccccactg ggccggggtg cgtcagaatg tgatgggctc 3600cagcatcgac ggccgacccg tcctgcccgc aaattccgcc acgctgacct atgcgaccgt 3660cgcggggacg ccgttggacg ccaccgccgc cgccgccgcc accgcagccg cctcggccgt 3720gcgcagcctg gccacggact ttgcattcct gggaccactg gcgacagggg ctacttctcg 3780ggccgctgct gccgccgttc gcgatgacaa gctgaccgcc ctgctggcgc agttggatgc 3840gcttactcgg gaactgggtg acctttctca gcaggtcatg gccctgcgcc agcaggtctc 3900ctccctgcaa gctggcggga atgcttctcc cacaaatgcc gtttaagata aataaaacca 3960gactctgttt ggattaaaga aaagtagcaa gtgcattgct ctctttattt cataattttc 4020cgcgcgcgat aggccctaga ccagcgttct cggtcgttga gggtgcggtg tatcttctcc 4080aggacgtggt agaggtggct ctggacgttg agatacatgg gcatgagccc gtcccggggg 4140tggaggtagc accactgcag agcttcatgc tccggggtgg tgttgtagat gatccagtcg 4200tagcaggagc gctgggcatg gtgcctaaaa atgtccttca gcagcaggcc gatggccagg 4260gggaggccct tggtgtaagt gtttacaaaa cggttaagtt gggaagggtg cattcgggga 4320gagatgatgt gcatcttgga ctgtattttt agattggcga tgtttccgcc cagatccctt 4380ctgggattca tgttgtgcag gaccaccagt acagtgtatc cggtgcactt ggggaatttg 4440tcatgcagct tagagggaaa agcgtggaag aacttggaga cgcctttgtg gcctcccaga 4500ttttccatgc attcgtccat gatgatggca atgggcccgc gggaggcagc ttgggcaaag 4560atatttctgg ggtcgctgac gtcgtagttg tgttccaggg tgaggtcgtc ataggccatt 4620tttacaaagc gcgggcggag ggtgcccgac tgggggatga tggtcccctc tggccctggg 4680gcgtagttgc cctcgcagat ctgcatttcc caggccttaa tctcggaggg gggaatcata 4740tccacctgcg gggcgatgaa gaaaacggtt tccggagccg gggagattaa ctgggatgag 4800agcaggtttc taagcagctg tgattttcca caaccggtgg gcccataaat aacacctata 4860accggttgca gctggtagtt tagagagctg cagctgccgt cgtcccggag gaggggggcc 4920acctcgttga gcatgtccct gacgcgcatg ttctccccga ccagatccgc cagaaggcgc 4980tcgccgccca gggacagcag ctcttgcaag gaagcaaagt ttttcagcgg cttgaggccg 5040tccgccgtgg gcatgttttt cagggtctgg ctcagcagct ccaggcggtc ccagagctcg 5100gtgacgtgct ctacggcatc tctatccagc atatctcctc gtttcgcggg ttggggcgac 5160tttcgctgta gggcaccaag cggtggtcgt ccagcggggc cagagtcatg tccttccatg 5220ggcgcagggt cctcgtcagg gtggtctggg tcacggtgaa ggggtgcgct ccgggctgag 5280cgcttgccaa ggtgcgcttg aggctggttc tgctggtgct gaagcgctgc cggtcttcgc 5340cctgcgcgtc ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt 5400gtcccttggc gcgcagcttg cccttggagg tggcgccgca cgaggggcag agcaggctct 5460tgagcgcgta gagcttgggg gcgaggaaga ccgattcggg ggagtaggcg tccgcgccgc 5520agaccccgca cacggtctcg cactccacca gccaggtgag ctcggggcgc gccgggtcaa 5580aaaccaggtt tcccccatgc tttttgatgc gtttcttacc tcgggtctcc atgaggtggt 5640gtccccgctc ggtgacgaag aggctgtccg tgtctccgta gaccgacttg aggggtcttt 5700tctccagggg ggtccctcgg tcttcctcgt agaggaactc ggaccactct gagacgaagg 5760cccgcgtcca ggccaggacg aaggaggcta tgtgggaggg gtagcggtcg ttgtccacta 5820gggggtccac cttctccaag gtgtgaagac acatgtcgcc ttcctcggcg tccaggaagg 5880tgattggctt gtaggtgtag gccacgtgac cgggggttcc tgacgggggg gtataaaagg 5940gggtgggggc gcgctcgtcg tcactctctt ccgcatcgct gtctgcgagg gccagctgct 6000ggggtgagta ttccctctcg aaggcgggca tgacctccgc gctgaggttg tcagtttcca 6060aaaacgagga ggatttgatg ttcacctgtc ccgaggtgat acctttgagg gtacccgcgt 6120ccatctggtc agaaaacacg atctttttat tgtccagctt ggtggcgaac gacccgtaga 6180gggcgttgga gagcagcttg gcgatggagc gcagggtctg gttcttgtcc ctgtcggcgc 6240gctccttggc cgcgatgttg agctgcacgt actcgcgcgc gacgcagcgc cactcgggga 6300agacggtggt gcgctcgtcg ggcaccaggc gcacgcgcca gccgcggttg tgcagggtga 6360ccaggtccac gctggtggcg acctcgccgc gcaggcgctc gttggtccag cagagacggc 6420cgcccttgcg cgagcagaag gggggcaggg ggtcgagctg ggtctcgtcc ggggggtccg 6480cgtccacggt gaaaaccccg gggcgcaggc gcgcgtcgaa gtagtctatc ttgcaacctt 6540gcatgtccag cgcctgctgc cagtcgcggg cggcgagcgc gcgctcgtag gggttgagcg 6600gcgggcccca gggcatgggg tgggtgagtg cggaggcgta catgccgcag atgtcataga 6660cgtagagggg ctcccgcagg accccgatgt aggtggggta gcagcggccg ccgcggatgc 6720tggcgcgcac gtagtcatac agctcgtgcg agggggcgag gaggtcgggg cccaggttgg 6780tgcgggcggg gcgctccgcg cggaagacga tctgcctgaa gatggcatgc gagttggaag 6840agatggtggg gcgctggaag acgttgaagc tggcgtcctg caggccgacg gcgtcgcgca 6900cgaaggaggc gtaggagtcg cgcagcttgt gtaccagctc ggcggtgacc tgcacgtcga 6960gcgcgcagta gtcgagggtc tcgcggatga tgtcatattt agcctgcccc ttctttttcc 7020acagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcgggaaac 7080cgtccggttc cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc 7140agcagccctt ctccacgggg agggcgtagg cctgcgcggc cttgcggagc gaggtgtggg 7200tcagggcgaa ggtgtccctg accatgactt tgaggtactg gtgcttgaag tcggagtcgt 7260cgcagccgcc ccgctcccag agcgagaagt cggtgcgctt cttggagcgg gggttgggca 7320gagcgaaggt gacatcgttg aagaggattt tgcccgcgcg gggcatgaag ttgcgggtga 7380tgcggaaggg ccccggcact tcagagcggt tgttgatgac ctgggcggcg agcacgatct 7440cgtcgaagcc gttgatgttg tggcccacga tgtagagttc caggaagcgg ggccggccct 7500ttacggtggg cagcttcttt agctcttcgt aggtgagctc ctcgggcgag gcgaggccgt 7560gctcggccag ggcccagtcc gcgaggtgcg ggttgtctct gaggaaggac ttccagaggt 7620cgcgggccag gagggtctgc aggcggtctc tgaaggtcct gaactggcgg cccacggcca 7680ttttttcggg ggtgatgcag tagaaggtga gggggtcttg ctgccagcgg tcccagtcga 7740gctgcagggc gaggtcgcgc gcggcggtga ccaggcgctc gtcgcccccg aatttcatga 7800ccagcatgaa gggcacgagc tgctttccga aggcccccat ccaagtgtag gtctctacat 7860cgtaggtgac aaagaggcgc tccgtgcgag gatgcgagcc gatcgggaag aactggatct 7920cccgccacca gttggaggag tggctgttga tgtggtggaa gtagaagtcc cgtcgccggg 7980ccgaacactc gtgctggctt ttgtaaaagc gagcgcagta ctggcagcgc tgcacgggct 8040gtacctcatg cacgagatgc acctttcgcc cgcgcacgag gaagccgagg ggaaatctga 8100gccccccgcc tggctcgcgg catggctggt tctcttctac tttggatgcg tgtccgtctc 8160cgtctggctc ctcgaggggt gttacggtgg agcggaccac cacgccgcgc gagccgcagg 8220tccagatatc ggcgcgcggc ggtcggagtt tgatgacgac atcgcgcagc tgggagctgt 8280ccatggtctg gagctcccgc ggcggcggca ggtcagccgg gagttcttgc aggttcacct 8340cgcagagtcg ggccagggcg cggggcaggt ctaggtggta cctgatctct aggggcgtgt 8400tggtggcggc gtcgatggct tgcaggagcc cgcagccccg gggggcgacg acggtgcccc 8460gcggggtggt ggtggtggtg gcggtgcagc tcagaagcgg tgccgcgggc gggcccccgg 8520aggtaggggg ggctccggtc ccgcgggcag gggcggcagc ggcacgtcgg cgtggagcgc 8580gggcaggagt tggtgctgtg cccggaggtt gctggcgaag gcgacgacgc ggcggttgat 8640ctcctggatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga acctgaaaga 8700gagttcgaca gaatcaatct cggtgtcatt gaccgcggcc tggcgcagga tctcctgcac 8760gtctcccgag ttgtcttggt aggcgatctc ggccatgaac tgctcgatct cttcctcctg 8820gaggtctccg cgtccggcgc gttccacggt ggccgccagg tcgttggaga tgcgccccat 8880gagctgcgag aaggcgttga gtccgccctc gttccagact cggctgtaga ccacgccccc 8940ctggtcatcg cgggcgcgca tgaccacctg cgcgaggttg agctccacgt gccgcgcgaa 9000gacggcgtag ttgcgcagac gctggaagag gtagttgagg gtggtggcgg tgtgctcggc 9060cacgaagaag ttcatgaccc agcggcgcaa cgtggattcg ttgatgtccc ccaaggcctc 9120cagccgttcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 9180cgacacggtc aactcctcct ccagaagacg gatgagctcg gcgacggtgt cgcgcacctc 9240gcgctcgaag gctatgggga tctcttcctc cgctagcatc accacctcct cctcttcctc 9300ctcttctggc acttccatga tggcttcctc ctcttcgggg ggtggcggcg gcggcggtgg 9360gggagggggc gctctgcgcc ggcggcggcg caccgggagg cggtccacga agcgcgcgat 9420catctccccg cggcggcggc gcatggtctc ggtgacggcg cggccgttct cccgggggcg 9480cagttggaag acgccgccgg acatctggtg ctggggcggg tggccgtgag gcagcgagac 9540ggcgctgacg atgcatctca acaattgctg cgtaggtacg ccgccgaggg acctgaggga 9600gtccatatcc accggatccg aaaacctttc gaggaaggcg tctaaccagt cgcagtcgca 9660aggtaggctg agcaccgtgg cgggcggcgg ggggtggggg gagtgtctgg cggaggtgct 9720gctgatgatg taattgaagt aggcggactt gacacggcgg atggtcgaca ggagcaccat 9780gtccttgggt ccggcctgct ggatgcggag gcggtcggct atgccccagg cttcgttctg 9840gcatcggcgc aggtccttgt agtagtcttg catgagcctt tccaccggca cctcttctcc 9900ttcctcttct gcttcttcca tgtctgcttc ggccctgggg cggcgccgcg cccccctgcc 9960ccccatgcgc gtgaccccga accccctgag cggttggagc agggccaggt cggcgacgac 10020gcgctcggcc aggatggcct gctgcacctg cgtgagggtg gtttggaagt catccaagtc 10080cacgaagcgg tggtaggcgc ccgtgttgat ggtgtaggtg cagttggcca tgacggacca 10140gttgacggtc tggtggcccg gttgcgacat ctcggtgtac ctgagtcgcg agtaggcgcg 10200ggagtcgaag acgtagtcgt tgcaagtccg caccaggtac tggtagccca ccaggaagtg 10260cggcggcggc tggcggtaga ggggccagcg cagggtggcg ggggctccgg gggccaggtc 10320ttccagcatg aggcggtggt aggcgtagat gtacctggac atccaggtga tacccgcggc 10380ggtggtggag gcgcgcggga agtcgcgcac ccggttccag atgttgcgca ggggcagaaa 10440gtgctccatg gtaggcgtgc tctgtccagt cagacgcgcg cagtcgttga tactctagac 10500cagggaaaac gaaagccggt cagcgggcac tcttccgtgg tctggtgaat agatcgcaag 10560ggtatcatgg cggagggcct cggttcgagc cccgggtccg ggccggacgg tccgccatga 10620tccacgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca acggtggagt 10680gttccttttg gcgtttttct ggccgggcgc cggcgccgcg taagagacta agccgcgaaa 10740gcgaaagcag taagtggctc gctccccgta gccggaggga tccttgctaa gggttgcgtt 10800gcggcgaacc ccggttcgaa tcccgtactc gggccggccg gacccgcggc taaggtgttg 10860gattggcctc cccctcgtat aaagaccccg cttgcggatt gactccggac acggggacga 10920gcccctttta tttttgcttt ccccagatgc atccggtgct gcggcagatg cgccccccgc 10980cccagcagca gcaacaacac cagcaagagc ggcagcaaca gcagcgggag tcatgcaggg 11040ccccctcacc caccctcggc gggccggcca cctcggcgtc cgcggccgtg tctggcgcct 11100gcggcggcgg cggggggccg gctgacgacc ccgaggagcc cccgcggcgc agggccagac 11160actacctgga cctggaggag ggcgagggcc tggcgcggct gggggcgccg tctcccgagc 11220gccacccgcg ggtgcagctg aagcgcgact cgcgcgaggc gtacgtgcct cggcagaacc 11280tgttcaggga ccgcgcgggc gaggagcccg aggagatgcg ggacaggagg ttcagcgcag 11340ggcgggagct gcggcagggg ctgaaccgcg agcggctgct gcgcgaggag gactttgagc 11400ccgacgcgcg gacggggatc agccccgcgc gcgcgcacgt ggcggccgcc gacctggtga 11460cggcgtacga gcagacggtg aaccaggaga tcaacttcca aaagagtttc aacaaccacg 11520tgcgcacgct ggtggcgcgc gaggaggtga ccatcgggct gatgcacctg tgggactttg 11580taagcgcgct ggtgcagaac cccaacagca agcctctgac ggcgcagctg ttcctgatag 11640tgcagcacag cagggacaac gaggcgttta gggacgcgct gctgaacatc accgagcccg 11700agggtcggtg gctgctggac ctgattaaca tcctgcagag catagtggtg caggagcgca 11760gcctgagcct ggccgacaag gtggcggcca tcaactactc gatgctgagc ctgggcaagt 11820tttacgcgcg caagatctac cagacgccgt acgtgcccat agacaaggag gtgaagatcg 11880acggttttta catgcgcatg gcgctgaagg tgctcaccct gagcgacgac ctgggcgtgt 11940accgcaacga gcgcatccac aaggccgtga gcgtgagccg gcggcgcgag ctgagcgacc 12000gcgagctgat gcacagcctg cagcgggcgc tggcgggcgc cggcagcggc gacagggagg 12060cggagtccta cttcgatgcg ggggcggacc tgcgctgggc gcccagccgg cgggccctgg 12120aggccgcggg ggtccgcgag gactatgacg aggacggcga ggaggatgag gagtacgagc 12180tagaggaggg cgagtacctg gactaaaccg cgggtggtgt ttccggtaga tgcaagaccc 12240gaacgtggtg gacccggcgc tgcgggcggc tctgcagagc cagccgtccg gccttaactc 12300ctcagacgac tggcgacagg tcatggaccg catcatgtcg ctgacggcgc gtaacccgga 12360cgcgttccgg cagcagccgc aggccaacag gctctccgcc atcctggagg cggtggtgcc 12420tgcgcgctcg aaccccacgc acgagaaggt gctggccata gtgaacgcgc tggccgagaa 12480cagggccatc cgcccggacg aggccgggct ggtgtacgac gcgctgctgc agcgcgtggc 12540ccgctacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg acgtgcgcga 12600ggcggtggcg cagcgcgagc gcgcggatcg gcagggcaac ctgggctcca tggtggcgct 12660gaatgccttc ctgagcacgc agccggccaa cgtgccgcgg gggcaggaag actacaccaa 12720ctttgtgagc gcgctgcggc tgatggtgac cgagaccccc cagagcgagg tgtaccagtc 12780gggcccggac tacttcttcc agaccagcag acagggcctg cagacggtga acctgagcca 12840ggctttcaag aacctgcggg ggctgtgggg cgtgaaggcg cccaccggcg accgggcgac 12900ggtgtccagc ctgctgacgc ccaactcgcg cctgctgctg ctgctgatcg cgccgttcac 12960ggacagcggc agcgtgtccc gggacaccta cctggggcac ctgctgaccc tgtaccgcga 13020ggccatcggg caggcgcagg tggacgagca caccttccag gagatcacca gcgtgagccg 13080cgcgctgggg caggaggaca cgagcagcct ggaggcgact ctgaactacc tgctgaccaa 13140ccggcggcag aagattccct cgctgcacag cctgacctcc gaggaggagc gcatcttgcg 13200ctacgtgcag cagagcgtga gcctgaacct gatgcgcgac ggggtgacgc ccagcgtggc 13260gctggacatg accgcgcgca acatggaacc gggcatgtac gccgcgcacc ggccttacat 13320caaccgcctg atggactacc tgcatcgcgc ggcggccgtg aaccccgagt actttaccaa 13380cgccatcctg aacccgcact ggctcccgcc gcccgggttc tacagcgggg gcttcgaggt 13440cccggagacc aacgatggct tcctgtggga cgacatggac gacagcgtgt tctccccgcg 13500gccgcaggcg ctggcggaag cgtccctgct gcgtcccaag aaggaggagg aggaggaggc 13560gagtcgccgc cgcggcagca gcggcgtggc ttctctgtcc gagctggggg cggcagccgc 13620cgcgcgcccc gggtccctgg gcggcagccc ctttccgagc ctggtggggt ctctgcacag 13680cgagcgcacc acccgccctc ggctgctggg cgaggacgag tacctgaata actccctgct 13740gcagccggtg cgggagaaaa acctgcctcc cgccttcccc aacaacggga tagagagcct 13800ggtggacaag atgagcagat ggaagaccta tgcgcaggag cacagggacg cgcctgcgct 13860ccggccgccc acgcggcgcc agcgccacga ccggcagcgg gggctggtgt gggatgacga 13920ggactccgcg gacgatagca gcgtgctgga cctgggaggg agcggcaacc cgttcgcgca 13980cctgcgcccc cgcctgggga ggatgtttta aaaaaaaaaa aaaaaagcaa gaagcatgat 14040gcaaaaatta aataaaactc accaaggcca tggcgaccga gcgttggttt cttgtgttcc 14100cttcagtatg cggcgcgcgg cgatgtacca ggagggacct cctccctctt acgagagcgt 14160ggtgggcgcg gcggcggcgg cgccctcttc tccctttgcg tcgcagctgc tggagccgcc 14220gtacgtgcct ccgcgctacc tgcggcctac gggggggaga aacagcatcc gttactcgga 14280gctggcgccc ctgttcgaca ccacccgggt gtacctggtg gacaacaagt cggcggacgt 14340ggcctccctg aactaccaga acgaccacag caattttttg accacggtca tccagaacaa 14400tgactacagc ccgagcgagg ccagcaccca gaccatcaat ctggatgacc ggtcgcactg 14460gggcggcgac ctgaaaacca tcctgcacac caacatgccc aacgtgaacg agttcatgtt 14520caccaataag ttcaaggcgc gggtgatggt gtcgcgctcg cacaccaagg aagaccgggt 14580ggagctgaag tacgagtggg tggagttcga gctgccagag ggcaactact ccgagaccat 14640gaccattgac ctgatgaaca acgcgatcgt ggagcactat ctgaaagtgg gcaggcagaa 14700cggggtcctg gagagcgaca tcggggtcaa gttcgacacc aggaacttcc gcctggggct 14760ggaccccgtg accgggctgg ttatgcccgg ggtgtacacc aacgaggcct tccatcccga 14820catcatcctg ctgcccggct gcggggtgga cttcacttac agccgcctga gcaacctcct 14880gggcatccgc aagcggcagc ccttccagga gggcttcagg atcacctacg aggacctgga 14940ggggggcaac atccccgcgc tcctcgatgt ggaggcctac caggatagct tgaaggaaaa 15000tgaggcggga caggaggata ccgcccccgc cgcctccgcc gccgccgagc agggcgagga 15060tgctgctgac accgcggccg cggacggggc agaggccgac cccgctatgg tggtggaggc 15120tcccgagcag gaggaggaca tgaatgacag tgcggtgcgc ggagacacct tcgtcacccg 15180gggggaggaa aagcaagcgg aggccgaggc cgcggccgag gaaaagcaac tggcggcagc 15240agcggcggcg gcggcgttgg ccgcggcgga ggctgagtct gaggggacca agcccgccaa 15300ggagcccgtg attaagcccc tgaccgaaga tagcaagaag cgcagttaca acctgctcaa 15360ggacagcacc aacaccgcgt accgcagctg gtacctggcc tacaactacg gcgacccgtc 15420gacgggggtg cgctcctgga ccctgctgtg cacgccggac gtgacctgcg gctcggagca 15480ggtgtactgg tcgctgcccg acatgatgca agaccccgtg accttccgct ccacgcggca 15540ggtcagcaac ttcccggtgg tgggcgccga gctgctgccc gtgcactcca agagcttcta 15600caacgaccag gccgtctact cccagctcat ccgccagttc acctctctga cccacgtgtt 15660caatcgcttt cctgagaacc agattctggc gcgcccgccc gcccccacca tcaccaccgt 15720cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca acagcatcgg 15780aggagtccag cgagtgaccg ttactgacgc cagacgccgc acctgcccct acgtttacaa 15840ggccttgggc atagtctcgc cgcgcgtcct ttccagccgc actttttgag caacaccacc 15900atcatgtcca tcctgatctc acccagcaat aactccggct ggggactgct gcgcgcgccc 15960agcaagatgt tcggaggggc gaggaagcgt tccgagcagc accccgtgcg cgtgcgcggg 16020cacttccgcg ccccctgggg agcgcacaaa cgcggccgcg cggggcgcac caccgtggac 16080gacgccatcg actcggtggt ggagcaggcg cgcaactaca ggcccgcggt ctctaccgtg 16140gacgcggcca tccagaccgt ggtgcggggc gcgcggcggt acgccaagct gaagagccgc 16200cggaagcgcg tggcccgccg ccaccgccgc cgacccgggg ccgccgccaa acgcgccgcc 16260gcggccctgc ttcgccgggc caagcgcacg ggccgccgcg ccgccatgag ggccgcgcgc 16320cgcttggccg ccggcatcac cgccgccacc atggcccccc gtacccgaag acgcgcggcc 16380gccgccgccg ccgccgccat cagtgacatg gccagcaggc gccggggcaa cgtgtactgg 16440gtgcgcgact cggtgaccgg cacgcgcgtg cccgtgcgct tccgcccccc gcggacttga 16500gatgatgtga aaaaacaaca ctgagtctcc tgctgttgtg tgtatcccag cggcggcggc 16560gcgcgcagcg tcatgtccaa gcgcaaaatc aaagaagaga tgctccaggt cgtcgcgccg 16620gagatctatg ggcccccgaa gaaggaagag caggattcga agccccgcaa gataaagcgg 16680gtcaaaaaga aaaagaaaga tgatgacgat gccgatgggg aggtggagtt cctgcgcgcc 16740acggcgccca ggcgcccggt gcagtggaag ggccggcgcg taaagcgcgt cctgcgcccc 16800ggcaccgcgg tggtcttcac gcccggcgag cgctccaccc ggactttcaa gcgcgtctat 16860gacgaggtgt acggcgacga agacctgctg gagcaggcca acgagcgctt cggagagttt 16920gcttacggga agcgtcagcg ggcgctgggg aaggaggacc tgctggcgct gccgctggac 16980cagggcaacc ccacccccag tctgaagccc gtgaccctgc agcaggtgct gccgagcagc 17040gcaccctccg aggcgaagcg gggtctgaag cgcgagggcg gcgacctggc gcccaccgtg 17100cagctcatgg tgcccaagcg gcagaggctg gaggatgtgc tggagaaaat gaaagtagac 17160cccggtctgc agccggacat cagggtccgc cccatcaagc aggtggcgcc gggcctcggc 17220gtgcagaccg tggacgtggt catccccacc ggcaactccc ccgccgccgc caccactacc 17280gctgcctcca cggacatgga gacacagacc gatcccgccg cagccgcagc cgcagccgcc 17340gccgcgacct cctcggcgga ggtgcagacg gacccctggc tgccgccggc gatgtcagct 17400ccccgcgcgc gtcgcgggcg caggaagtac ggcgccgcca acgcgctcct gcccgagtac 17460gccttgcatc cttccatcgc gcccaccccc ggctaccgag gctataccta ccgcccgcga 17520agagccaagg gttccacccg ccgtccccgc cgacgcgccg ccgccaccac ccgccgccgc 17580cgccgcagac gccagcccgc actggctcca gtctccgtga ggaaagtggc gcgcgacgga 17640cacaccctgg tgctgcccag ggcgcgctac caccccagca tcgtttaaaa gcctgttgtg 17700gttcttgcag atatggccct cacttgccgc ctccgtttcc cggtgccggg ataccgagga 17760ggaagatcgc gccgcaggag gggtctggcc

ggccgcggcc tgagcggagg cagccgccgc 17820gcgcaccggc ggcgacgcgc caccagccga cgcatgcgcg gcggggtgct gcccctgtta 17880atccccctga tcgccgcggc gatcggcgcc gtgcccggga tcgcctccgt ggccttgcaa 17940gcgtcccaga ggcattgaca gacttgcaaa cttgcaaata tggaaaaaaa aaccccaata 18000aaaaagtcta gactctcacg ctcgcttggt cctgtgacta ttttgtagaa tggaagacat 18060caactttgcg tcgctggccc cgcgtcacgg ctcgcgcccg ttcctgggac actggaacga 18120tatcggcacc agcaacatga gcggtggcgc cttcagttgg ggctctctgt ggagcggcat 18180taaaagtatc gggtctgccg ttaaaaatta cggctcccgg gcctggaaca gcagcacggg 18240ccagatgttg agagacaagt tgaaagagca gaacttccag cagaaggtgg tggagggcct 18300ggcctccggc atcaacgggg tggtggacct ggccaaccag gccgtgcaga ataagatcaa 18360cagcagactg gacccccggc cgccggtgga ggaggtgccg ccggcgctgg agacggtgtc 18420ccccgatggg cgtggcgaga agcgcccgcg gcccgatagg gaagagacca ctctggtcac 18480gcagaccgat gagccgcccc cgtatgagga ggccctgaag caaggtctgc ccaccacgcg 18540gcccatcgcg cccatggcca ccggggtggt gggccgccac acccccgcca cgctggactt 18600gcctccgccc gccgatgtgc cgcagcagca gaaggcggca cagccgggcc cgcccgcgac 18660cgcctcccgt tcctccgccg gtcctctgcg ccgcgcggcc agcggccccc gcgggggggt 18720cgcgaggcac ggcaactggc agagcacgct gaacagcatc gtgggtctgg gggtgcggtc 18780cgtgaagcgc cgccgatgct actgaatagc ttagctaacg tgttgtatgt gtgtatgcgc 18840cctatgtcgc cgccagagga gctgctgagt cgccgccgtt cgcgcgccca ccaccaccgc 18900cactccgccc ctcaagatgg cgaccccatc gatgatgccg cagtggtcgt acatgcacat 18960ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagttcg cccgcgccac 19020cgagagctac ttcagcctga gtaacaagtt taggaacccc acggtggcgc ccacgcacga 19080tgtgaccacc gaccggtctc agcgcctgac gctgcggttc attcccgtgg accgcgagga 19140caccgcgtac tcgtacaagg cgcggttcac cctggccgtg ggcgacaacc gcgtgctgga 19200catggcctcc acctactttg acatccgcgg ggtgctggac cggggtccca ctttcaagcc 19260ctactctggc accgcctaca actccctggc ccccaagggc gctcccaact cctgcgagtg 19320ggagcaagag gaaactcagg cagttgaaga agcagcagaa gaggaagaag aagatgctga 19380cggtcaagct gaggaagagc aagcagctac caaaaagact catgtatatg ctcaggctcc 19440cctttctggc gaaaaaatta gtaaagatgg tctgcaaata ggaacggacg ctacagctac 19500agaacaaaaa cctatttatg cagaccctac attccagccc gaaccccaaa tcggggagtc 19560ccagtggaat gaggcagatg ctacagtcgc cggcggtaga gtgctaaaga aatctactcc 19620catgaaacca tgctatggtt cctatgcaag acccacaaat gctaatggag gtcagggtgt 19680actaacggca aatgcccagg gacagctaga atctcaggtt gaaatgcaat tcttttcaac 19740ttctgaaaac gcccgtaacg aggctaacaa cattcagccc aaattggtgc tgtatagtga 19800ggatgtgcac atggagaccc cggatacgca cctttcttac aagcccgcaa aaagcgatga 19860caattcaaaa atcatgctgg gtcagcagtc catgcccaac agacctaatt acatcggctt 19920cagagacaac tttatcggcc tcatgtatta caatagcact ggcaacatgg gagtgcttgc 19980aggtcaggcc tctcagttga atgcagtggt ggacttgcaa gacagaaaca cagaactgtc 20040ctaccagctc ttgcttgatt ccatgggtga cagaaccaga tacttttcca tgtggaatca 20100ggcagtggac agttatgacc cagatgttag aattattgaa aatcatggaa ctgaagacga 20160gctccccaac tattgtttcc ctctgggtgg cataggggta actgacactt accaggctgt 20220taaaaccaac aatggcaata acgggggcca ggtgacttgg acaaaagatg aaacttttgc 20280agatcgcaat gaaatagggg tgggaaacaa tttcgctatg gagatcaacc tcagtgccaa 20340cctgtggaga aacttcctgt actccaacgt ggcgctgtac ctaccagaca agcttaagta 20400caacccctcc aatgtggaca tctctgacaa ccccaacacc tacgattaca tgaacaagcg 20460agtggtggcc ccggggctgg tggactgcta catcaacctg ggcgcgcgct ggtcgctgga 20520ctacatggac aacgtcaacc ccttcaacca ccaccgcaat gcgggcctgc gctaccgctc 20580catgctcctg ggcaacgggc gctacgtgcc cttccacatc caggtgcccc agaagttctt 20640tgccatcaag aacctcctcc tcctgccggg ctcctacacc tacgagtgga acttcaggaa 20700ggatgtcaac atggtcctcc agagctctct gggtaacgat ctcagggtgg acggggccag 20760catcaagttc gagagcatct gcctctacgc caccttcttc cccatggccc acaacacggc 20820ctccacgctc gaggccatgc tcaggaacga caccaacgac cagtccttca atgactacct 20880ctccgccgcc aacatgctct accccatacc cgccaacgcc accaacgtcc ccatctccat 20940cccctcgcgc aactgggcgg ccttccgcgg ctgggccttc acccgcctca agaccaagga 21000gaccccctcc ctgggctcgg gattcgaccc ctactacacc tactcgggct ccattcccta 21060cctggacggc accttctacc tcaaccacac tttcaagaag gtctcggtca ccttcgactc 21120ctcggtcagc tggccgggca acgaccgtct gctcaccccc aacgagttcg agatcaagcg 21180ctcggtcgac ggggagggct acaacgtggc ccagtgcaac atgaccaagg actggttcct 21240ggtccagatg ctggccaact acaacatcgg ctaccagggc ttctacatcc cagagagcta 21300caaggacagg atgtactcct tcttcaggaa cttccagccc atgagccggc aggtggtgga 21360ccagaccaag tacaaggact accaggaggt gggcatcatc caccagcaca acaactcggg 21420cttcgtgggc tacctcgccc ccaccatgcg cgagggacag gcctaccccg ccaacttccc 21480ctatccgctc ataggcaaga ccgcggtcga cagcatcacc cagaaaaagt tcctctgcga 21540ccgcaccctc tggcgcatcc ccttctccag caacttcatg tccatgggtg cgctctcgga 21600cctgggccag aacttgctct acgccaactc cgcccacgcc ctcgacatga ccttcgaggt 21660cgaccccatg gacgagccca cccttctcta tgttctgttc gaagtctttg acgtggtccg 21720ggtccaccag ccgcaccgcg gcgtcatcga gaccgtgtac ctgcgtacgc ccttctcggc 21780cggcaacgcc accacctaaa gaagcaagcc gcagtcatcg ccgcctgcat gccgtcgggt 21840tccaccgagc aagagctcag ggccatcgtc agagacctgg gatgcgggcc ctattttttg 21900ggcaccttcg acaagcgctt ccctggcttt gtctccccac acaagctggc ctgcgccatc 21960gtcaacacgg ccggccgcga gaccgggggc gtgcactggc tggccttcgc ctggaacccg 22020cgctccaaaa catgcttcct ctttgacccc ttcggctttt cggaccagcg gctcaagcaa 22080atctacgagt tcgagtacga gggcttgctg cgtcgcagcg ccatcgcctc ctcgcccgac 22140cgctgcgtca ccctcgaaaa gtccacccag accgtgcagg ggcccgactc ggccgcctgc 22200ggtctcttct gctgcatgtt tctgcacgcc tttgtgcact ggcctcagag tcccatggac 22260cgcaacccca ccatgaactt gctgacgggg gtgcccaact ccatgctcca gagcccccag 22320gtcgagccca ccctgcgccg caaccaggag cagctctaca gcttcctgga gcgccactcg 22380ccttacttcc gccgccacag cgcacagatc aggagggcca cctccttctg ccacttgcaa 22440gagatgcaag aagggtaata acgatgtaca cacttttttt ctcaataaat ggcatctttt 22500tatttataca agctctctgg ggtattcatt tcccaccacc acccgccgtt gtcgccatct 22560ggctctattt agaaatcgaa agggttctgc cgggagtcgc cgtgcgccac gggcagggac 22620acgttgcgat actggtagcg ggtgccccac ttgaactcgg gcaccaccag gcgaggcagc 22680tcggggaagt tttcgctcca caggctgcgg gtcagcacca gcgcgttcat caggtcgggc 22740gccgagatct tgaagtcgca gttggggccg ccgccctgcg cgcgcgagtt gcggtacacc 22800gggttgcagc actggaacac caacagcgcc gggtgcttca cgctggccag cacgctgcgg 22860tcggagatca gctcggcgtc caggtcctcc gcgttgctca gcgcgaacgg ggtcatcttg 22920ggcacttgcc gccccaggaa gggcgcgtgc cccggtttcg agttgcagtc gcagcgcagc 22980gggatcagca ggtgcccgtg cccggactcg gcgttggggt acagcgcgcg catgaaggcc 23040tgcatctggc ggaaggccat ctgggccttg gcgccctccg agaagaacat gccgcaggac 23100ttgcccgaga actggtttgc ggggcagctg gcgtcgtgca ggcagcagcg cgcgtcggtg 23160ttggcgatct gcaccacgtt gcgcccccac cggttcttca cgatcttggc cttggacgat 23220tgctccttca gcgcgcgctg cccgttctcg ctggtcacat ccatctcgat cacatgttcc 23280ttgttcacca tgctgctgcc gtgcagacac ttcagctcgc cctccgtctc ggtgcagcgg 23340tgctgccaca gcgcgcagcc cgtgggctcg aaagacttgt aggtcacctc cgcgaaggac 23400tgcaggtacc cctgcaaaaa gcggcccatc atggtcacga aggtcttgtt gctgctgaag 23460gtcagctgca gcccgcggtg ctcctcgttc agccaggtct tgcacacggc cgccagcgcc 23520tccacctggt cgggcagcat cttgaagttc accttcagct cattctccac gtggtacttg 23580tccatcagcg tgcgcgccgc ctccatgccc ttctcccagg ccgacaccag cggcaggctc 23640acggggttct tcaccatcac cgtggccgcc gcctccgccg cgctttcgct ttccgccccg 23700ctgttctctt cctcttcctc ctcttcctcg ccgccgccca ctcgcagccc ccgcaccacg 23760gggtcgtctt cctgcaggcg ctgcaccttg cgcttgccgt tgcgcccctg cttgatgcgc 23820acgggcgggt tgctgaagcc caccatcacc agcgcggcct cttcttgctc gtcctcgctg 23880tccagaatga cctccgggga gggggggttg gtcatcctca gtaccgaggc acgcttcttt 23940ttcttcctgg gggcgttcgc cagctccgcg gctgcggccg ctgccgaggt cgaaggccga 24000gggctgggcg tgcgcggcac cagcgcgtcc tgcgagccgt cctcgtcctc ctcggactcg 24060agacggaggc gggcccgctt cttcgggggc gcgcggggcg gcggaggcgg cggcggcgac 24120ggagacgggg acgagacatc gtccagggtg ggtggacggc gggccgcgcc gcgtccgcgc 24180tcgggggtgg tctcgcgctg gtcctcttcc cgactggcca tctcccactg ctccttctcc 24240tataggcaga aagagatcat ggagtctctc atgcgagtcg agaaggagga ggacagccta 24300accgccccct ctgagccctc caccaccgcc gccaccaccg ccaatgccgc cgcggacgac 24360gcgcccaccg agaccaccgc cagtaccacc ctccccagcg acgcaccccc gctcgagaat 24420gaagtgctga tcgagcagga cccgggtttt gtgagcggag aggaggatga ggtggatgag 24480aaggagaagg aggaggtcgc cgcctcagtg ccaaaagagg ataaaaagca agaccaggac 24540gacgcagata aggatgagac agcagtcggg cgggggaacg gaagccatga tgctgatgac 24600ggctacctag acgtgggaga cgacgtgctg cttaagcacc tgcaccgcca gtgcgtcatc 24660gtctgcgacg cgctgcagga gcgctgcgaa gtgcccctgg acgtggcgga ggtcagccgc 24720gcctacgagc ggcacctctt cgcgccgcac gtgcccccca agcgccggga gaacggcacc 24780tgcgagccca acccgcgtct caacttctac ccggtcttcg cggtacccga ggtgctggcc 24840acctaccaca tctttttcca aaactgcaag atccccctct cctgccgcgc caaccgcacc 24900cgcgccgaca aaaccctgac cctgcggcag ggcgcccaca tacctgatat cgcctctctg 24960gaggaagtgc ccaagatctt cgagggtctc ggtcgcgacg agaaacgggc ggcgaacgct 25020ctgcacggag acagcgaaaa cgagagtcac tcgggggtgc tggtggagct cgagggcgac 25080aacgcgcgcc tggccgtact caagcgcagc atagaggtca cccactttgc ctacccggcg 25140ctcaacctgc cccccaaggt catgagtgtg gtcatgggcg agctcatcat gcgccgcgcc 25200cagcccctgg ccgcggatgc aaacttgcaa gagtcctccg aggaaggcct gcccgcggtc 25260agcgacgagc agctggcgcg ctggctggag acccgcgacc ccgcgcagct ggaggagcgg 25320cgcaagctca tgatggccgc ggtgctggtc accgtggagc tcgagtgtct gcagcgcttc 25380ttcgcggacc ccgagatgca gcgcaagctc gaggagaccc tgcactacac cttccgccag 25440ggctacgtgc gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac 25500ctgggcatcc tgcacgagaa ccgcctcggg cagaacgtcc tgcactccac cctcaaaggg 25560gaggcgcgcc gcgactacat ccgcgactgc gcctacctct tcctctgcta cacctggcag 25620acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga gctggaaaag 25680ctcctcaagc gcaccctcag ggacctctgg acgggcttca acgagcgctc ggtggccgcc 25740gcgctggcgg acatcatctt tcccgagcgc ctgctcaaga ccctgcagca gggcctgccc 25800gacttcacca gccagagcat gctgcagaac ttcaggactt tcatcctgga gcgctcgggc 25860atcctgccgg ccacttgctg cgcgctgccc agcgacttcg tgcccatcaa gtacagggag 25920tgcccgccgc cgctctgggg ccactgctac ctcttccagc tggccaacta cctcgcctac 25980cactcggacc tcatggaaga cgtgagcggc gagggcctgc tcgagtgcca ctgccgctgc 26040aacctctgca cgccccaccg ctctctagtc tgcaacccgc agctgctcag cgagagtcag 26100attatcggta ccttcgagct gcagggtccc tcgcctgacg agaagtccgc ggctccaggg 26160ctgaaactca ctccggggct gtggacttcc gcctacctac gcaaatttgt acctgaggac 26220taccacgccc acgagatcag gttctacgaa gaccaatccc gcccgcccaa ggcggagctc 26280accgcctgcg tcatcaccca ggggcacatc ctgggccaat tgcaagccat caacaaagcc 26340cgccgagagt tcttgctgaa aaagggtcgg ggggtgtacc tggaccccca gtccggcgag 26400gagctaaacc cgctaccccc gccgccgccc cagcagcggg accttgcttc ccaggatggc 26460acccagaaag aagcagcagc cgccgccgcc gccgcagcca tacatgcttc tggaggaaga 26520ggaggaggac tgggacagtc aggcagagga ggtttcggac gaggagcagg aggagatgat 26580ggaagactgg gaggaggaca gcagcctaga cgaggaagct tcagaggccg aagaggtggc 26640agacgcaaca ccatcgccct cggtcgcagc cccctcgccg gggcccctga aatcctccga 26700acccagcacc agcgctataa cctccgctcc tccggcgccg gcgccacccg cccgcagacc 26760caaccgtaga tgggacacca caggaaccgg ggtcggtaag tccaagtgcc cgccgccgcc 26820accgcagcag cagcagcagc agcgccaggg ctaccgctcg tggcgcgggc acaagaacgc 26880catagtcgcc tgcttgcaag actgcggggg caacatctct ttcgcccgcc gcttcctgct 26940attccaccac ggggtcgcct ttccccgcaa tgtcctgcat tactaccgtc atctctacag 27000cccctactgc agcggcgacc cagaggcggc agcggcagcc acagcggcga ccaccaccta 27060ggaagatatc ctccgcgggc aagacagcgg cagcagcggc caggagaccc gcggcagcag 27120cggcgggagc ggtgggcgca ctgcgcctct cgcccaacga acccctctcg acccgggagc 27180tcagacacag gatcttcccc actttgtatg ccatcttcca acagagcaga ggccaggagc 27240aggagctgaa aataaaaaac agatctctgc gctccctcac ccgcagctgt ctgtatcaca 27300aaagcgaaga tcagcttcgg cgcacgctgg aggacgcgga ggcactcttc agcaaatact 27360gcgcgctcac tcttaaagac tagctccgcg cccttctcga atttaggcgg gagaaaacta 27420cgtcatcgcc ggccgccgcc cagcccgccc agccgagatg agcaaagaga ttcccacgcc 27480atacatgtgg agctaccagc cgcagatggg actcgcggcg ggagcggccc aggactactc 27540cacccgcatg aactacatga gcgcgggacc ccacatgatc tcacaggtca acgggatccg 27600cgcccagcga aaccaaatac tgctggaaca ggcggccatc accgccacgc cccgccataa 27660tctcaacccc cgaaattggc ccgccgccct cgtgtaccag gaaaccccct ccgccaccac 27720cgtactactt ccgcgtgacg cccaggccga agtccagatg actaactcag gggcgcagct 27780cgcgggcggc tttcgtcacg gggcgcggcc gctccgacca ggtataagac acctgatgat 27840cagaggccga ggtatccagc tcaacgacga gtcggtgagc tcttcgctcg gtctccgtcc 27900ggacggaact ttccagctcg ccggatccgg ccgctcttcg ttcacgcccc gccaggcgta 27960cctgactctg cagacctcgt cctcggagcc ccgctccggc ggcatcggaa ccctccagtt 28020cgtggaggag ttcgtgccct cggtctactt caaccccttc tcgggacctc ccggacgcta 28080ccccgaccag ttcattccga actttgacgc ggtgaaggac tcggcggacg gctacgactg 28140aatgtcaggt gtcgaggcag agcagcttcg cctgagacac ctcgagcact gccgccgcca 28200caagtgcttc gcccgcggtt ctggtgagtt ctgctacttt cagctacccg aggagcatac 28260cgaggggccg gcgcacggcg tccgcctgac cacccagggc gaggttacct gttccctcat 28320ccgggagttt accctccgtc ccctgctagt ggagcgggag cggggtccct gtgtcctaac 28380tatcgcctgc aactgcccta accctggatt acatcaagat ctttgctgtc atctctgtgc 28440tgagtttaat aaacgctgag atcagaatct actggggctc ctgtcgccat cctgtgaacg 28500ccaccgtctt cacccacccc gaccaggccc aggcgaacct cacctgcggt ctgcatcgga 28560gggccaagaa gtacctcacc tggtacttca acggcacccc ctttgtggtt tacaacagct 28620tcgacgggga cggagtctcc ctgaaagacc agctctccgg tctcagctac tccatccaca 28680agaacaccac cctccaactc ttccctccct acctgccggg aacctacgag tgcgtcaccg 28740gccgctgcac ccacctcacc cgcctgatcg taaaccagag ctttccggga acagataact 28800ccctcttccc cagaacagga ggtgagctca ggaaactccc cggggaccag ggcggagacg 28860taccttcgac ccttgtgggg ttaggatttt ttattaccgg gttgctggct cttttaatca 28920aagtttcctt gagatttgtt ctttccttct acgtgtatga acacctcaac ctccaataac 28980tctacccttt cttcggaatc aggtgacttc tctgaaatcg ggcttggtgt gctgcttact 29040ctgttgattt ttttccttat catactcagc cttctgtgcc tcaggctcgc cgcctgctgc 29100gcacacatct atatctactg ctggttgctc aagtgcaggg gtcgccaccc aagatgaaca 29160ggtacatggt cctatcgatc ctaggcctgc tggccctggc ggcctgcagc gccgccaaaa 29220aagagattac ctttgaggag cccgcttgca atgtaacttt caagcccgag ggtgaccaat 29280gcaccaccct cgtcaaatgc gttaccaatc atgagaggct gcgcatcgac tacaaaaaca 29340aaactggcca gtttgcggtc tatagtgtgt ttacgcccgg agacccctct aactactctg 29400tcaccgtctt ccagggcgga cagtctaaga tattcaatta cactttccct ttttatgagt 29460tatgcgatgc ggtcatgtac atgtcaaaac agtacaacct gtggcctccc tctccccagg 29520cgtgtgtgga aaatactggg tcttactgct gtatggcttt cgcaatcact acgctcgctc 29580taatctgcac ggtgctatac ataaaattca ggcagaggcg aatctttatc gatgaaaaga 29640aaatgccttg atcgctaaca ccggctttct atctgcagaa tgaatgcaat cacctcccta 29700ctaatcacca ccaccctcct tgcgattgcc catgggttga cacgaatcga agtgccagtg 29760gggtccaatg tcaccatggt gggccccgcc ggcaattcca ccctcatgtg ggaaaaattt 29820gtccgcaatc aatgggttca tttctgctct aaccgaatca gtatcaagcc cagagccatc 29880tgcgatgggc aaaatctaac tctgatcaat gtgcaaatga tggatgctgg gtactattac 29940gggcagcggg gagaaatcat taattactgg cgaccccaca aggactacat gctgcatgta 30000gtcgaggcac ttcccactac cacccccact accacctctc ccaccaccac caccactact 30060actactacta ctactactac tactactacc actaccgctg cccgccatac ccgcaaaagc 30120accatgatta gcacaaagcc ccctcgtgct cactcccacg ccggcgggcc catcggtgcg 30180acctcagaaa ccaccgagct ttgcttctgc caatgcacta acgccagcgc tcatgaactg 30240ttcgacctgg agaatgagga tgtccagcag agctccgctt gcctgaccca ggaggctgtg 30300gagcccgttg ccctgaagca gatcggtgat tcaataattg actcttcttc ttttgccact 30360cccgaatacc ctcccgattc tactttccac atcacgggta ccaaagaccc taacctctct 30420ttctacctga tgctgctgct ctgtatctct gtggtctctt ccgcgctgat gttactgggg 30480atgttctgct gcctgatctg ccgcagaaag agaaaagctc gctctcaggg ccaaccactg 30540atgcccttcc cctacccccc ggattttgca gataacaaga tatgagctcg ctgctgacac 30600taaccgcttt actagcctgc gctctaaccc ttgtcgcttg cgactcgaga ttccacaatg 30660tcacagctgt ggcaggagaa aatgttactt tcaactccac ggccgatacc cagtggtcgt 30720ggagtggctc aggtagctac ttaactatct gcaatagctc cacttccccc ggcatatccc 30780caaccaagta ccaatgcaat gccagcctgt tcaccctcat caacgcttcc accctggaca 30840atggactcta tgtaggctat gtaccctttg gtgggcaagg aaagacccac gcttacaacc 30900tggaagttcg ccagcccaga accactaccc aagcttctcc caccaccacc accaccacca 30960ccatcaccag cagcagcagc agcagcagcc acagcagcag cagcagatta ttgactttgg 31020ttttggccag ctcatctgcc gctacccagg ccatctacag ctctgtgccc gaaaccactc 31080agatccaccg cccagaaacg accaccgcca ccaccctaca cacctccagc gatcagatgc 31140cgaccaacat cacccccttg gctcttcaaa tgggacttac aagccccact ccaaaaccag 31200tggatgcggc cgaggtctcc gccctcgtca atgactgggc ggggctggga atgtggtggt 31260tcgccatagg catgatggcg ctctgcctgc ttctgctctg gctcatctgc tgcctccacc 31320gcaggcgagc cagacccccc atctatagac ccatcattgt cctgaacccc gataatgatg 31380ggatccatag attggatggc ctgaaaaacc tacttttttc ttttacagta tgataaattg 31440agacatgcct cgcattttct tgtacatgtt ccttctccca ccttttctgg ggtgttctac 31500gctggccgct gtgtctcacc tggaggtaga ctgcctctca cccttcactg tctacctgct 31560ttacggattg gtcaccctca ctctcatctg cagcctaatc acagtaatca tcgccttcat 31620ccagtgcatt gattacatct gtgtgcgcct cgcatacttc agacaccacc cgcagtaccg 31680agacaggaac attgcccaac ttctaagact gctctaatca tgcataagac tgtgatctgc 31740cttctgatcc tctgcatcct gcccaccctc acctcctgcc agtacaccac aaaatctccg 31800cgcaaaagac atgcctcctg ccgcttcacc caactgtgga atatacccaa atgctacaac 31860gaaaagagcg agctctccga agcttggctg tatggggtca tctgtgtctt agttttctgc 31920agcactgtct ttgccctcat aatctacccc tactttgatt tgggatggaa cgcgatcgat 31980gccatgaatt accccacctt tcccgcaccc gagataattc cactgcgaca agttgtaccc 32040gttgtcgtta atcaacgccc cccatcccct acgcccactg aaatcagcta ctttaaccta 32100acaggcggag atgactgacg ccctagatct agaaatggac ggcatcagta ccgagcagcg 32160tctcctagag aggcgcaggc aggcggctga gcaagagcgc ctcaatcagg agctccgaga 32220tctcgttaac ctgcaccagt gcaaaagagg catcttttgt ctggtaaagc aggccaaagt 32280cacctacgag aagaccggca acagccaccg cctcagttac aaattgccca cccagcgcca 32340gaagctggtg ctcatggtgg gtgagaatcc catcaccgtc acccagcact cggtagagac 32400cgaggggtgt ctgcactccc cctgtcgggg tccagaagac ctctgcaccc tggtaaagac 32460cctgtgcggt ctcagagatt tagtcccctt taactaatca aacactggaa tcaataaaaa 32520gaatcactta cttaaaatca gacagcaggt ctctgtccag tttattcagc agcacctcct 32580tcccctcctc ccaactctgg tactccaaac gccttctggc ggcaaacttc ctccacaccc 32640tgaagggaat gtcagattct tgctcctgtc cctccgcacc cactatcttc atgttgttgc 32700agatgaagcg caccaaaacg tctgacgaga gcttcaaccc cgtgtacccc tatgacacgg 32760aaagcggccc tccctccgtc cctttcctca cccctccctt cgtgtctccc gatggattcc 32820aagaaagtcc ccccggggtc ctgtctctga

acctggccga gcccctggtc acttcccacg 32880gcatgctcgc cctgaaaatg ggaagtggcc tctccctgga cgacgctggc aacctcacct 32940ctcaagatat caccaccgct agccctcccc tcaaaaaaac caagaccaac ctcagcctag 33000aaacctcatc ccccctaact gtgagcacct caggcgccct caccgtagca gccgccgctc 33060ccctggcggt ggccggcacc tccctcacca tgcaatcaga ggcccccctg acagtacagg 33120atgcaaaact caccctggcc accaaaggcc ccctgaccgt gtctgaaggc aaactggcct 33180tgcaaacatc ggccccgctg acggccgctg acagcagcac cctcacagtc agtgccacac 33240caccccttag cacaagcaat ggcagcttgg gtattgacat gcaagccccc atttacacca 33300ccaatggaaa actaggactt aactttggcg ctcccctgca tgtggtagac agcctaaatg 33360cactgactgt agttactggc caaggtctta cgataaacgg aacagcccta caaactagag 33420tctcaggtgc cctcaactat gacacatcag gaaacctaga attgagagct gcagggggta 33480tgcgagttga tgcaaatggt caacttatcc ttgatgtagc ttacccattt gatgcacaaa 33540acaatctcag ccttaggctt ggacagggac ccctgtttgt taactctgcc cacaacttgg 33600atgttaacta caacagaggc ctctacctgt tcacatctgg aaataccaaa aagctagaag 33660ttaatatcaa aacagccaag ggtctcattt atgatgacac tgctatagca atcaatgcgg 33720gtgatgggct acagtttgac tcaggctcag atacaaatcc attaaaaact aaacttggat 33780taggactgga ttatgactcc agcagagcca taattgctaa actgggaact ggcctaagct 33840ttgacaacac aggtgccatc acagtaggca acaaaaatga tgacaagctt accttgtgga 33900ccacaccaga cccatcccct aactgtagaa tctattcaga gaaagatgct aaattcacac 33960ttgttttgac taaatgcggc agtcaggtgt tggccagcgt ttctgtttta tctgtaaaag 34020gtagccttgc gcccatcagt ggcacagtaa ctagtgctca gattgtcctc agatttgatg 34080aaaatggagt tctactaagc aattcttccc ttgaccctca atactggaac tacagaaaag 34140gtgaccttac agagggcact gcatatacca acgcagtggg atttatgccc aacctcacag 34200catacccaaa aacacagagc caaactgcta aaagcaacat tgtaagtcag gtttacttga 34260atggggacaa atccaaaccc atgaccctca ccattaccct caatggaact aatgaaacag 34320gagatgccac agtaagcact tactccatgt cattctcatg gaactggaat ggaagtaatt 34380acattaatga aacgttccaa accaactcct tcaccttctc ctacatcgcc caagaataaa 34440aagcatgacg ctgttgattt gattcaatgt gtttctgttt tattttcaag cacaacaaaa 34500tcattcaagt cattcttcca tcttagctta atagacacag tagcttaata gacccagtag 34560tgcaaagccc cattctagct tataactagt ggagaagtac tcgcctacat gggggtagag 34620tcataatcgt gcatcaggat agggcggtgg tgctgcagca gcgcgcgaat aaactgctgc 34680cgccgccgct ccgtcctgca ggaatacaac atggcagtgg tctcctcagc gatgattcgc 34740accgcccgca gcataaggcg ccttgtcctc cgggcacagc agcgcaccct gatctcactt 34800aaatcagcac agtaactgca gcacagcacc acaatattgt tcaaaatccc acagtgcaag 34860gcgctgtatc caaagctcat ggcggggacc acagaaccca cgtggccatc ataccacaag 34920cgcaggtaga ttaagtggcg acccctcata aacacgctgg acataaacat tacctctttt 34980ggcatgttgt aattcaccac ctcccggtac catataaacc tctgattaaa catggcgcca 35040tccaccacca tcctaaacca gctggccaaa acctgcccgc cggctataca ctgcagggaa 35100ccgggactgg aacaatgaca gtggagagcc caggactcgt aaccatggat catcatgctc 35160gtcatgatat caatgttggc acaacacagg cacacgtgca tacacttcct caggattaca 35220agctcctccc gcgttagaac catatcccag ggaacaaccc attcctgaat cagcgtaaat 35280cccacactgc agggaagacc tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat 35340tcgggcagca gcggatgatc ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt 35400agacgatccc tactgtacgg agtgcgccga gacaaccgag atcgtgttgg tcgtagtgtc 35460atgccaaatg gaacgccgga cgtagtcata tttcctgaag tcttagatct ctcaacgcag 35520caccagcacc aacacttcgc agtgtaaaag gccaagtgcc gagagagtat atataggaat 35580aaaaagtgac gtaaacgggc aaagtccaaa aaacgcccag aaaaaccgca cgcgaaccta 35640cgccccgaaa cgaaagccaa aaaacactag acactccctt ccggcgtcaa cttccgcttt 35700cccacgctac gtcacttgcc ccagtcaaac aaactacata tcccgaactt ccaagtcgcc 35760acgcccaaaa caccgcctac acctccccgc ccgccggccc gcccccaaac ccgcctcccg 35820ccccgcgccc cgccccgcgc cgcccatctc attatcatat tggcttcaat ccaaaataag 35880gtatattatt gatgatggtt taaacggatc ctctagagtc gacctgcagg catgcaagct 35940tgagtattct atagtgtcac ctaaatagct tggcgtaatc atggtcatag ctgtttcctg 36000tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta 36060aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg 36120ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgaacccc 36180ttgcggccgc ccgggccgtc gaccaattct catgtttgac agcttatcat cgaatttctg 36240ccattcatcc gcttattatc acttattcag gcgtagcaac caggcgttta agggcaccaa 36300taactgcctt aaaaaaatta cgccccgccc tgccactcat cgcagtactg ttgtaattca 36360ttaagcattc tgccgacatg gaagccatca caaacggcat gatgaacctg aatcgccagc 36420ggcatcagca ccttgtcgcc ttgcgtataa tatttgccca tggtgaaaac gggggcgaag 36480aagttgtcca tattggccac gtttaaatca aaactggtga aactcaccca gggattggct 36540gagacgaaaa acatattctc aataaaccct ttagggaaat aggccaggtt ttcaccgtaa 36600cacgccacat cttgcgaata tatgtgtaga aactgccgga aatcgtcgtg gtattcactc 36660cagagcgatg aaaacgtttc agtttgctca tggaaaacgg tgtaacaagg gtgaacacta 36720tcccatatca ccagctcacc gtctttcatt gccatacgga attccggatg agcattcatc 36780aggcgggcaa gaatgtgaat aaaggccgga taaaacttgt gcttattttt ctttacggtc 36840tttaaaaagg ccgtaatatc cagctgaacg gtctggttat aggtacattg agcaactgac 36900tgaaatgcct caaaatgttc tttacgatgc cattgggata tatcaacggt ggtatatcca 36960gtgatttttt tctccatttt agcttcctta gctcctgaaa atctcgataa ctcaaaaaat 37020acgcccggta gtgatcttat ttcattatgg tgaaagttgg aacctcttac gtgccgatca 37080acgtctcatt ttcgccaaaa gttggcccag ggcttcccgg tatcaacagg gacaccagga 37140tttatttatt ctgcgaagtg atcttccgtc acaggtattt attcgcgata agctcatgga 37200gcggcgtaac cgtcgcacag gaaggacaga gaaagcgcgg atctgggaag tgacggacag 37260aacggtcagg acctggattg gggaggcggt tgccgccgct gctgctgacg gtgtgacgtt 37320ctctgttccg gtcacaccac atacgttccg ccattcctat gcgatgcaca tgctgtatgc 37380cggtataccg ctgaaagttc tgcaaagcct gatgggacat aagtccatca gttcaacgga 37440agtctacacg aaggtttttg cgctggatgt ggctgcccgg caccgggtgc agtttgcgat 37500gccggagtct gatgcggttg cgatgctgaa acaattatcc tgagaataaa tgccttggcc 37560tttatatgga aatgtggaac tgagtggata tgctgttttt gtctgttaaa cagagaagct 37620ggctgttatc cactgagaag cgaacgaaac agtcgggaaa atctcccatt atcgtagaga 37680tccgcattat taatctcagg agcctgtgta gcgtttatag gaagtagtgt tctgtcatga 37740tgcctgcaag cggtaacgaa aacgatttga atatgccttc aggaacaata gaaatcttcg 37800tgcggtgtta cgttgaagtg gagcggatta tgtcagcaat ggacagaaca acctaatgaa 37860cacagaacca tgatgtggtc tgtcctttta cagccagtag tgctcgccgc agtcgagcga 37920cagggcgaag ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct 37980tacacacgat gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt 38040tataattatt ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta 38100tccatgctgg ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc 38160ctcaaatgac agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag 38220aagaagctgt tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac 38280aatctaaaaa cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat 38340cacaagaaac gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca 38400tatagtctct cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa 38460tctgatggca ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct 38520gaaatattcg gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt 38580ttcgcgggga aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc 38640tatgaatctt ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt 38700gtacatatca acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag 38760tttcggctta gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc 38820ctgtgtcagt atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc 38880atagagcgtt accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc 38940ctgcaggtct gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag 39000aaaaagaaag gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg 39060acgacaggat agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt 39120ctgacctact gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt 39180ctcatacttt ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt 39240tgatttcctt ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat 39300tgatgagggt tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct 39360acctggagtt tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac 39420agaacagttc ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg 39480gcgagcgcta gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg 39540ttgctcttat tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt 39600tgcagtaaat tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa 39660tgaaactcat ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta 39720tcgccattgc acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga 39780gaataggtga agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga 39840aagcagggcg actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg 39900gttatacaat tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg 39960ctgaagacgt atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa 40020cctcagtttc tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg 40080tggaaggtaa cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc 40140atattcatgc agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt 40200atgcaataaa gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc 40260accgtattga aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac 40320acctgatgct ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg 40380acagcgcgcc taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga 40440ttgttcccac gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc 40500ttcgtgatct gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc 40560ttaccaaata cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg 40620atgcctgggg aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag 40680gtcagatccg gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg 40740cctggagaaa tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga 40800ttaaaccacg ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct 40860caatactcaa ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc 40920gttaattgcg cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg 40980tcgggatgtg aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg 41040ggtatggtca ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct 41100catcccttct tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg 41160tgtcatagaa attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga 41220ttatcgtgtt ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg 41280taacgattat cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca 41340gaatgaattt gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat 41400tattacccgc tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca 41460ccccggtgaa ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga 41520ggaattactt aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt 41580tgaagctgaa gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag 41640aactagttta agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga 41700taaaatggtg cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga 41760ggccattctt aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt 41820ttatctgtct ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat 41880tctctctggg cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg 41940tcccactcgt atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg 42000gtctgattat tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg 42060ggaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc 42120gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt 42180attagtctgg aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg 42240gtcccactcg tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc 42300ggtctgatta tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt 42360gagactacga ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt 42420agaacggagt aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc 42480ttatccacaa cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc 42540cggcacgtta accgggctgc atccgatgca agtgtgtcgc tgtcgacgag ctcgcgagct 42600cggacatgag gttgccccgt attcagtgtc gctgatttgt attgtctgaa gttgttttta 42660cgttaagttg atgcagatca attaatacga tacctgcgtc ataattgatt atttgacgtg 42720gtttgatggc ctccacgcac gttgtgatat gtagatgata atcattatca ctttacgggt 42780cctttccggt gatccgacag gttacggggc ggcgacctcg cgggttttcg ctatttatga 42840aaattttccg gtttaaggcg tttccgttct tcttcgtcat aacttaatgt ttttatttaa 42900aataccctct gaaaagaaag gaaacgacag gtgctgaaag cgagcttttt ggcctctgtc 42960gtttcctttc tctgtttttg tccgtggaat gaacaatgga agtccgagct catcgctaat 43020aacttcgtat agcatacatt atacgaagtt atattcgatg cggccgcaag gggttcgcgt 43080cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac 43140tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca 43200tcaggcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct 43260cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa 43320cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgaattg taatacgact 43380cactataggg cgaattcgag ctcggtaccc ggggatcctc gtttaaac 43428945227DNASimian adenovirus 9catcatcaat aatatacctt attttggatt gaagccaata tgataatgag atgggcggcg 60cggggcgggg cgcggggcgg gaggcgggtt tgggggcggg ccggcgggcg gggcggtgtg 120gcggaagtgg actttgtaag tgtggcggat gtgacttgct agtgccgggc gcggtaaaag 180tgacgttttc cgtgcgcgac aacgcccccg ggaagtgaca tttttcccgc ggtttttacc 240ggatgttgta gtgaatttgg gcgtaaccaa gtaagatttg gccattttcg cgggaaaact 300gaaacgggga agtgaaatct gattaatttt gcgttagtca taccgcgtaa tatttgtcta 360gggccgaggg actttggccg attacgtgga ggactcgccc aggtgttttt tgaggtgaat 420ttccgcgttc cgggtcaaag tctgcgtttt attattatag gatatcccat tgcatacgtt 480gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg 540acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 600atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 660cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 720tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 780agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 840gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 900agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 960gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 1020gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 1080gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag 1140agatctccct atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc 1200ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct 1260ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg agatcttccg 1320tttatctagg taccgggccc cccctcgagg tcgacggtat cgataagctt cacgctgccg 1380caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag ccagtccgca 1440gaaacggtgc tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc 1500aagcgcaaag agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc 1560ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg 1620gaagccctgc aaagtaaact ggatggcttt cttgccgcca aggatctgat ggcgcagggg 1680atcaagatct aaccaggagc tatttaatgg caacagttaa ccagctggta cgcaaaccac 1740gtgctcgcaa agttgcgaaa agcaacgtgc ctgcgctgga agcatgcccg caaaaacgtg 1800gcgtatgtac tcgtgtatat actaccactc ctaaaaaacc gaactccgcg ctgcgtaaag 1860tatgccgtgt tcgtctgact aacggtttcg aagtgacttc ctacatcggt ggtgaaggtc 1920acaacctgca ggagcactcc gtgatcctga tccgtggcgg tcgtgttaaa gacctcccgg 1980gtgttcgtta ccacaccgta cgtggtgcgc ttgactgctc cggcgttaaa gaccgtaagc 2040aggctcgttc caagtatggc gtgaagcgtc ctaaggctta atggtagatc tgatcaagag 2100acaggatgac ggtcgtttcg catgcttgaa caagatggat tgcacgcagg ttctccggcc 2160gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat 2220gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg 2280tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg 2340ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta 2400ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta 2460tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc 2520gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc 2580gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg 2640ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg 2700ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt 2760gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc 2820ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc 2880atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga 2940ccgaccaagc gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg 3000aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg 3060atctcatgct ggagttcttc gcccaccccg ggctcgatcc cctcgggggg aatcagaatt 3120cagtcgacag cggccgcgat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc 3180ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 3240tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 3300gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg 3360ctctatggcc gatcagcgat cgctgaggtg ggtgagtggg cgtggcctgg ggtggtcatg 3420aaaatatata agttgggggt cttagggtct ctttatttgt gttgcagaga ccgccggagc 3480catgagcggg agcagcagca gcagcagtag cagcagcgcc ttggatggca gcatcgtgag 3540cccttatttg acgacgcgga tgccccactg ggccggggtg cgtcagaatg tgatgggctc 3600cagcatcgac ggccgacccg tcctgcccgc aaattccgcc acgctgacct atgcgaccgt 3660cgcggggacg ccgttggacg ccaccgccgc cgccgccgcc accgcagccg cctcggccgt 3720gcgcagcctg gccacggact ttgcattcct gggaccactg gcgacagggg ctacttctcg 3780ggccgctgct gccgccgttc gcgatgacaa gctgaccgcc ctgctggcgc agttggatgc 3840gcttactcgg gaactgggtg acctttctca gcaggtcatg gccctgcgcc agcaggtctc 3900ctccctgcaa gctggcggga atgcttctcc cacaaatgcc gtttaagata aataaaacca 3960gactctgttt ggattaaaga aaagtagcaa gtgcattgct ctctttattt cataattttc 4020cgcgcgcgat aggccctaga ccagcgttct cggtcgttga gggtgcggtg tatcttctcc 4080aggacgtggt agaggtggct ctggacgttg agatacatgg gcatgagccc gtcccggggg 4140tggaggtagc accactgcag agcttcatgc tccggggtgg tgttgtagat gatccagtcg 4200tagcaggagc gctgggcatg gtgcctaaaa atgtccttca gcagcaggcc gatggccagg 4260gggaggccct tggtgtaagt gtttacaaaa cggttaagtt gggaagggtg cattcgggga 4320gagatgatgt gcatcttgga ctgtattttt agattggcga tgtttccgcc cagatccctt 4380ctgggattca tgttgtgcag gaccaccagt acagtgtatc cggtgcactt ggggaatttg

4440tcatgcagct tagagggaaa agcgtggaag aacttggaga cgcctttgtg gcctcccaga 4500ttttccatgc attcgtccat gatgatggca atgggcccgc gggaggcagc ttgggcaaag 4560atatttctgg ggtcgctgac gtcgtagttg tgttccaggg tgaggtcgtc ataggccatt 4620tttacaaagc gcgggcggag ggtgcccgac tgggggatga tggtcccctc tggccctggg 4680gcgtagttgc cctcgcagat ctgcatttcc caggccttaa tctcggaggg gggaatcata 4740tccacctgcg gggcgatgaa gaaaacggtt tccggagccg gggagattaa ctgggatgag 4800agcaggtttc taagcagctg tgattttcca caaccggtgg gcccataaat aacacctata 4860accggttgca gctggtagtt tagagagctg cagctgccgt cgtcccggag gaggggggcc 4920acctcgttga gcatgtccct gacgcgcatg ttctccccga ccagatccgc cagaaggcgc 4980tcgccgccca gggacagcag ctcttgcaag gaagcaaagt ttttcagcgg cttgaggccg 5040tccgccgtgg gcatgttttt cagggtctgg ctcagcagct ccaggcggtc ccagagctcg 5100gtgacgtgct ctacggcatc tctatccagc atatctcctc gtttcgcggg ttggggcgac 5160tttcgctgta gggcaccaag cggtggtcgt ccagcggggc cagagtcatg tccttccatg 5220ggcgcagggt cctcgtcagg gtggtctggg tcacggtgaa ggggtgcgct ccgggctgag 5280cgcttgccaa ggtgcgcttg aggctggttc tgctggtgct gaagcgctgc cggtcttcgc 5340cctgcgcgtc ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt 5400gtcccttggc gcgcagcttg cccttggagg tggcgccgca cgaggggcag agcaggctct 5460tgagcgcgta gagcttgggg gcgaggaaga ccgattcggg ggagtaggcg tccgcgccgc 5520agaccccgca cacggtctcg cactccacca gccaggtgag ctcggggcgc gccgggtcaa 5580aaaccaggtt tcccccatgc tttttgatgc gtttcttacc tcgggtctcc atgaggtggt 5640gtccccgctc ggtgacgaag aggctgtccg tgtctccgta gaccgacttg aggggtcttt 5700tctccagggg ggtccctcgg tcttcctcgt agaggaactc ggaccactct gagacgaagg 5760cccgcgtcca ggccaggacg aaggaggcta tgtgggaggg gtagcggtcg ttgtccacta 5820gggggtccac cttctccaag gtgtgaagac acatgtcgcc ttcctcggcg tccaggaagg 5880tgattggctt gtaggtgtag gccacgtgac cgggggttcc tgacgggggg gtataaaagg 5940gggtgggggc gcgctcgtcg tcactctctt ccgcatcgct gtctgcgagg gccagctgct 6000ggggtgagta ttccctctcg aaggcgggca tgacctccgc gctgaggttg tcagtttcca 6060aaaacgagga ggatttgatg ttcacctgtc ccgaggtgat acctttgagg gtacccgcgt 6120ccatctggtc agaaaacacg atctttttat tgtccagctt ggtggcgaac gacccgtaga 6180gggcgttgga gagcagcttg gcgatggagc gcagggtctg gttcttgtcc ctgtcggcgc 6240gctccttggc cgcgatgttg agctgcacgt actcgcgcgc gacgcagcgc cactcgggga 6300agacggtggt gcgctcgtcg ggcaccaggc gcacgcgcca gccgcggttg tgcagggtga 6360ccaggtccac gctggtggcg acctcgccgc gcaggcgctc gttggtccag cagagacggc 6420cgcccttgcg cgagcagaag gggggcaggg ggtcgagctg ggtctcgtcc ggggggtccg 6480cgtccacggt gaaaaccccg gggcgcaggc gcgcgtcgaa gtagtctatc ttgcaacctt 6540gcatgtccag cgcctgctgc cagtcgcggg cggcgagcgc gcgctcgtag gggttgagcg 6600gcgggcccca gggcatgggg tgggtgagtg cggaggcgta catgccgcag atgtcataga 6660cgtagagggg ctcccgcagg accccgatgt aggtggggta gcagcggccg ccgcggatgc 6720tggcgcgcac gtagtcatac agctcgtgcg agggggcgag gaggtcgggg cccaggttgg 6780tgcgggcggg gcgctccgcg cggaagacga tctgcctgaa gatggcatgc gagttggaag 6840agatggtggg gcgctggaag acgttgaagc tggcgtcctg caggccgacg gcgtcgcgca 6900cgaaggaggc gtaggagtcg cgcagcttgt gtaccagctc ggcggtgacc tgcacgtcga 6960gcgcgcagta gtcgagggtc tcgcggatga tgtcatattt agcctgcccc ttctttttcc 7020acagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcgggaaac 7080cgtccggttc cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc 7140agcagccctt ctccacgggg agggcgtagg cctgcgcggc cttgcggagc gaggtgtggg 7200tcagggcgaa ggtgtccctg accatgactt tgaggtactg gtgcttgaag tcggagtcgt 7260cgcagccgcc ccgctcccag agcgagaagt cggtgcgctt cttggagcgg gggttgggca 7320gagcgaaggt gacatcgttg aagaggattt tgcccgcgcg gggcatgaag ttgcgggtga 7380tgcggaaggg ccccggcact tcagagcggt tgttgatgac ctgggcggcg agcacgatct 7440cgtcgaagcc gttgatgttg tggcccacga tgtagagttc caggaagcgg ggccggccct 7500ttacggtggg cagcttcttt agctcttcgt aggtgagctc ctcgggcgag gcgaggccgt 7560gctcggccag ggcccagtcc gcgaggtgcg ggttgtctct gaggaaggac ttccagaggt 7620cgcgggccag gagggtctgc aggcggtctc tgaaggtcct gaactggcgg cccacggcca 7680ttttttcggg ggtgatgcag tagaaggtga gggggtcttg ctgccagcgg tcccagtcga 7740gctgcagggc gaggtcgcgc gcggcggtga ccaggcgctc gtcgcccccg aatttcatga 7800ccagcatgaa gggcacgagc tgctttccga aggcccccat ccaagtgtag gtctctacat 7860cgtaggtgac aaagaggcgc tccgtgcgag gatgcgagcc gatcgggaag aactggatct 7920cccgccacca gttggaggag tggctgttga tgtggtggaa gtagaagtcc cgtcgccggg 7980ccgaacactc gtgctggctt ttgtaaaagc gagcgcagta ctggcagcgc tgcacgggct 8040gtacctcatg cacgagatgc acctttcgcc cgcgcacgag gaagccgagg ggaaatctga 8100gccccccgcc tggctcgcgg catggctggt tctcttctac tttggatgcg tgtccgtctc 8160cgtctggctc ctcgaggggt gttacggtgg agcggaccac cacgccgcgc gagccgcagg 8220tccagatatc ggcgcgcggc ggtcggagtt tgatgacgac atcgcgcagc tgggagctgt 8280ccatggtctg gagctcccgc ggcggcggca ggtcagccgg gagttcttgc aggttcacct 8340cgcagagtcg ggccagggcg cggggcaggt ctaggtggta cctgatctct aggggcgtgt 8400tggtggcggc gtcgatggct tgcaggagcc cgcagccccg gggggcgacg acggtgcccc 8460gcggggtggt ggtggtggtg gcggtgcagc tcagaagcgg tgccgcgggc gggcccccgg 8520aggtaggggg ggctccggtc ccgcgggcag gggcggcagc ggcacgtcgg cgtggagcgc 8580gggcaggagt tggtgctgtg cccggaggtt gctggcgaag gcgacgacgc ggcggttgat 8640ctcctggatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga acctgaaaga 8700gagttcgaca gaatcaatct cggtgtcatt gaccgcggcc tggcgcagga tctcctgcac 8760gtctcccgag ttgtcttggt aggcgatctc ggccatgaac tgctcgatct cttcctcctg 8820gaggtctccg cgtccggcgc gttccacggt ggccgccagg tcgttggaga tgcgccccat 8880gagctgcgag aaggcgttga gtccgccctc gttccagact cggctgtaga ccacgccccc 8940ctggtcatcg cgggcgcgca tgaccacctg cgcgaggttg agctccacgt gccgcgcgaa 9000gacggcgtag ttgcgcagac gctggaagag gtagttgagg gtggtggcgg tgtgctcggc 9060cacgaagaag ttcatgaccc agcggcgcaa cgtggattcg ttgatgtccc ccaaggcctc 9120cagccgttcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 9180cgacacggtc aactcctcct ccagaagacg gatgagctcg gcgacggtgt cgcgcacctc 9240gcgctcgaag gctatgggga tctcttcctc cgctagcatc accacctcct cctcttcctc 9300ctcttctggc acttccatga tggcttcctc ctcttcgggg ggtggcggcg gcggcggtgg 9360gggagggggc gctctgcgcc ggcggcggcg caccgggagg cggtccacga agcgcgcgat 9420catctccccg cggcggcggc gcatggtctc ggtgacggcg cggccgttct cccgggggcg 9480cagttggaag acgccgccgg acatctggtg ctggggcggg tggccgtgag gcagcgagac 9540ggcgctgacg atgcatctca acaattgctg cgtaggtacg ccgccgaggg acctgaggga 9600gtccatatcc accggatccg aaaacctttc gaggaaggcg tctaaccagt cgcagtcgca 9660aggtaggctg agcaccgtgg cgggcggcgg ggggtggggg gagtgtctgg cggaggtgct 9720gctgatgatg taattgaagt aggcggactt gacacggcgg atggtcgaca ggagcaccat 9780gtccttgggt ccggcctgct ggatgcggag gcggtcggct atgccccagg cttcgttctg 9840gcatcggcgc aggtccttgt agtagtcttg catgagcctt tccaccggca cctcttctcc 9900ttcctcttct gcttcttcca tgtctgcttc ggccctgggg cggcgccgcg cccccctgcc 9960ccccatgcgc gtgaccccga accccctgag cggttggagc agggccaggt cggcgacgac 10020gcgctcggcc aggatggcct gctgcacctg cgtgagggtg gtttggaagt catccaagtc 10080cacgaagcgg tggtaggcgc ccgtgttgat ggtgtaggtg cagttggcca tgacggacca 10140gttgacggtc tggtggcccg gttgcgacat ctcggtgtac ctgagtcgcg agtaggcgcg 10200ggagtcgaag acgtagtcgt tgcaagtccg caccaggtac tggtagccca ccaggaagtg 10260cggcggcggc tggcggtaga ggggccagcg cagggtggcg ggggctccgg gggccaggtc 10320ttccagcatg aggcggtggt aggcgtagat gtacctggac atccaggtga tacccgcggc 10380ggtggtggag gcgcgcggga agtcgcgcac ccggttccag atgttgcgca ggggcagaaa 10440gtgctccatg gtaggcgtgc tctgtccagt cagacgcgcg cagtcgttga tactctagac 10500cagggaaaac gaaagccggt cagcgggcac tcttccgtgg tctggtgaat agatcgcaag 10560ggtatcatgg cggagggcct cggttcgagc cccgggtccg ggccggacgg tccgccatga 10620tccacgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca acggtggagt 10680gttccttttg gcgtttttct ggccgggcgc cggcgccgcg taagagacta agccgcgaaa 10740gcgaaagcag taagtggctc gctccccgta gccggaggga tccttgctaa gggttgcgtt 10800gcggcgaacc ccggttcgaa tcccgtactc gggccggccg gacccgcggc taaggtgttg 10860gattggcctc cccctcgtat aaagaccccg cttgcggatt gactccggac acggggacga 10920gcccctttta tttttgcttt ccccagatgc atccggtgct gcggcagatg cgccccccgc 10980cccagcagca gcaacaacac cagcaagagc ggcagcaaca gcagcgggag tcatgcaggg 11040ccccctcacc caccctcggc gggccggcca cctcggcgtc cgcggccgtg tctggcgcct 11100gcggcggcgg cggggggccg gctgacgacc ccgaggagcc cccgcggcgc agggccagac 11160actacctgga cctggaggag ggcgagggcc tggcgcggct gggggcgccg tctcccgagc 11220gccacccgcg ggtgcagctg aagcgcgact cgcgcgaggc gtacgtgcct cggcagaacc 11280tgttcaggga ccgcgcgggc gaggagcccg aggagatgcg ggacaggagg ttcagcgcag 11340ggcgggagct gcggcagggg ctgaaccgcg agcggctgct gcgcgaggag gactttgagc 11400ccgacgcgcg gacggggatc agccccgcgc gcgcgcacgt ggcggccgcc gacctggtga 11460cggcgtacga gcagacggtg aaccaggaga tcaacttcca aaagagtttc aacaaccacg 11520tgcgcacgct ggtggcgcgc gaggaggtga ccatcgggct gatgcacctg tgggactttg 11580taagcgcgct ggtgcagaac cccaacagca agcctctgac ggcgcagctg ttcctgatag 11640tgcagcacag cagggacaac gaggcgttta gggacgcgct gctgaacatc accgagcccg 11700agggtcggtg gctgctggac ctgattaaca tcctgcagag catagtggtg caggagcgca 11760gcctgagcct ggccgacaag gtggcggcca tcaactactc gatgctgagc ctgggcaagt 11820tttacgcgcg caagatctac cagacgccgt acgtgcccat agacaaggag gtgaagatcg 11880acggttttta catgcgcatg gcgctgaagg tgctcaccct gagcgacgac ctgggcgtgt 11940accgcaacga gcgcatccac aaggccgtga gcgtgagccg gcggcgcgag ctgagcgacc 12000gcgagctgat gcacagcctg cagcgggcgc tggcgggcgc cggcagcggc gacagggagg 12060cggagtccta cttcgatgcg ggggcggacc tgcgctgggc gcccagccgg cgggccctgg 12120aggccgcggg ggtccgcgag gactatgacg aggacggcga ggaggatgag gagtacgagc 12180tagaggaggg cgagtacctg gactaaaccg cgggtggtgt ttccggtaga tgcaagaccc 12240gaacgtggtg gacccggcgc tgcgggcggc tctgcagagc cagccgtccg gccttaactc 12300ctcagacgac tggcgacagg tcatggaccg catcatgtcg ctgacggcgc gtaacccgga 12360cgcgttccgg cagcagccgc aggccaacag gctctccgcc atcctggagg cggtggtgcc 12420tgcgcgctcg aaccccacgc acgagaaggt gctggccata gtgaacgcgc tggccgagaa 12480cagggccatc cgcccggacg aggccgggct ggtgtacgac gcgctgctgc agcgcgtggc 12540ccgctacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg acgtgcgcga 12600ggcggtggcg cagcgcgagc gcgcggatcg gcagggcaac ctgggctcca tggtggcgct 12660gaatgccttc ctgagcacgc agccggccaa cgtgccgcgg gggcaggaag actacaccaa 12720ctttgtgagc gcgctgcggc tgatggtgac cgagaccccc cagagcgagg tgtaccagtc 12780gggcccggac tacttcttcc agaccagcag acagggcctg cagacggtga acctgagcca 12840ggctttcaag aacctgcggg ggctgtgggg cgtgaaggcg cccaccggcg accgggcgac 12900ggtgtccagc ctgctgacgc ccaactcgcg cctgctgctg ctgctgatcg cgccgttcac 12960ggacagcggc agcgtgtccc gggacaccta cctggggcac ctgctgaccc tgtaccgcga 13020ggccatcggg caggcgcagg tggacgagca caccttccag gagatcacca gcgtgagccg 13080cgcgctgggg caggaggaca cgagcagcct ggaggcgact ctgaactacc tgctgaccaa 13140ccggcggcag aagattccct cgctgcacag cctgacctcc gaggaggagc gcatcttgcg 13200ctacgtgcag cagagcgtga gcctgaacct gatgcgcgac ggggtgacgc ccagcgtggc 13260gctggacatg accgcgcgca acatggaacc gggcatgtac gccgcgcacc ggccttacat 13320caaccgcctg atggactacc tgcatcgcgc ggcggccgtg aaccccgagt actttaccaa 13380cgccatcctg aacccgcact ggctcccgcc gcccgggttc tacagcgggg gcttcgaggt 13440cccggagacc aacgatggct tcctgtggga cgacatggac gacagcgtgt tctccccgcg 13500gccgcaggcg ctggcggaag cgtccctgct gcgtcccaag aaggaggagg aggaggaggc 13560gagtcgccgc cgcggcagca gcggcgtggc ttctctgtcc gagctggggg cggcagccgc 13620cgcgcgcccc gggtccctgg gcggcagccc ctttccgagc ctggtggggt ctctgcacag 13680cgagcgcacc acccgccctc ggctgctggg cgaggacgag tacctgaata actccctgct 13740gcagccggtg cgggagaaaa acctgcctcc cgccttcccc aacaacggga tagagagcct 13800ggtggacaag atgagcagat ggaagaccta tgcgcaggag cacagggacg cgcctgcgct 13860ccggccgccc acgcggcgcc agcgccacga ccggcagcgg gggctggtgt gggatgacga 13920ggactccgcg gacgatagca gcgtgctgga cctgggaggg agcggcaacc cgttcgcgca 13980cctgcgcccc cgcctgggga ggatgtttta aaaaaaaaaa aaaaaagcaa gaagcatgat 14040gcaaaaatta aataaaactc accaaggcca tggcgaccga gcgttggttt cttgtgttcc 14100cttcagtatg cggcgcgcgg cgatgtacca ggagggacct cctccctctt acgagagcgt 14160ggtgggcgcg gcggcggcgg cgccctcttc tccctttgcg tcgcagctgc tggagccgcc 14220gtacgtgcct ccgcgctacc tgcggcctac gggggggaga aacagcatcc gttactcgga 14280gctggcgccc ctgttcgaca ccacccgggt gtacctggtg gacaacaagt cggcggacgt 14340ggcctccctg aactaccaga acgaccacag caattttttg accacggtca tccagaacaa 14400tgactacagc ccgagcgagg ccagcaccca gaccatcaat ctggatgacc ggtcgcactg 14460gggcggcgac ctgaaaacca tcctgcacac caacatgccc aacgtgaacg agttcatgtt 14520caccaataag ttcaaggcgc gggtgatggt gtcgcgctcg cacaccaagg aagaccgggt 14580ggagctgaag tacgagtggg tggagttcga gctgccagag ggcaactact ccgagaccat 14640gaccattgac ctgatgaaca acgcgatcgt ggagcactat ctgaaagtgg gcaggcagaa 14700cggggtcctg gagagcgaca tcggggtcaa gttcgacacc aggaacttcc gcctggggct 14760ggaccccgtg accgggctgg ttatgcccgg ggtgtacacc aacgaggcct tccatcccga 14820catcatcctg ctgcccggct gcggggtgga cttcacttac agccgcctga gcaacctcct 14880gggcatccgc aagcggcagc ccttccagga gggcttcagg atcacctacg aggacctgga 14940ggggggcaac atccccgcgc tcctcgatgt ggaggcctac caggatagct tgaaggaaaa 15000tgaggcggga caggaggata ccgcccccgc cgcctccgcc gccgccgagc agggcgagga 15060tgctgctgac accgcggccg cggacggggc agaggccgac cccgctatgg tggtggaggc 15120tcccgagcag gaggaggaca tgaatgacag tgcggtgcgc ggagacacct tcgtcacccg 15180gggggaggaa aagcaagcgg aggccgaggc cgcggccgag gaaaagcaac tggcggcagc 15240agcggcggcg gcggcgttgg ccgcggcgga ggctgagtct gaggggacca agcccgccaa 15300ggagcccgtg attaagcccc tgaccgaaga tagcaagaag cgcagttaca acctgctcaa 15360ggacagcacc aacaccgcgt accgcagctg gtacctggcc tacaactacg gcgacccgtc 15420gacgggggtg cgctcctgga ccctgctgtg cacgccggac gtgacctgcg gctcggagca 15480ggtgtactgg tcgctgcccg acatgatgca agaccccgtg accttccgct ccacgcggca 15540ggtcagcaac ttcccggtgg tgggcgccga gctgctgccc gtgcactcca agagcttcta 15600caacgaccag gccgtctact cccagctcat ccgccagttc acctctctga cccacgtgtt 15660caatcgcttt cctgagaacc agattctggc gcgcccgccc gcccccacca tcaccaccgt 15720cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca acagcatcgg 15780aggagtccag cgagtgaccg ttactgacgc cagacgccgc acctgcccct acgtttacaa 15840ggccttgggc atagtctcgc cgcgcgtcct ttccagccgc actttttgag caacaccacc 15900atcatgtcca tcctgatctc acccagcaat aactccggct ggggactgct gcgcgcgccc 15960agcaagatgt tcggaggggc gaggaagcgt tccgagcagc accccgtgcg cgtgcgcggg 16020cacttccgcg ccccctgggg agcgcacaaa cgcggccgcg cggggcgcac caccgtggac 16080gacgccatcg actcggtggt ggagcaggcg cgcaactaca ggcccgcggt ctctaccgtg 16140gacgcggcca tccagaccgt ggtgcggggc gcgcggcggt acgccaagct gaagagccgc 16200cggaagcgcg tggcccgccg ccaccgccgc cgacccgggg ccgccgccaa acgcgccgcc 16260gcggccctgc ttcgccgggc caagcgcacg ggccgccgcg ccgccatgag ggccgcgcgc 16320cgcttggccg ccggcatcac cgccgccacc atggcccccc gtacccgaag acgcgcggcc 16380gccgccgccg ccgccgccat cagtgacatg gccagcaggc gccggggcaa cgtgtactgg 16440gtgcgcgact cggtgaccgg cacgcgcgtg cccgtgcgct tccgcccccc gcggacttga 16500gatgatgtga aaaaacaaca ctgagtctcc tgctgttgtg tgtatcccag cggcggcggc 16560gcgcgcagcg tcatgtccaa gcgcaaaatc aaagaagaga tgctccaggt cgtcgcgccg 16620gagatctatg ggcccccgaa gaaggaagag caggattcga agccccgcaa gataaagcgg 16680gtcaaaaaga aaaagaaaga tgatgacgat gccgatgggg aggtggagtt cctgcgcgcc 16740acggcgccca ggcgcccggt gcagtggaag ggccggcgcg taaagcgcgt cctgcgcccc 16800ggcaccgcgg tggtcttcac gcccggcgag cgctccaccc ggactttcaa gcgcgtctat 16860gacgaggtgt acggcgacga agacctgctg gagcaggcca acgagcgctt cggagagttt 16920gcttacggga agcgtcagcg ggcgctgggg aaggaggacc tgctggcgct gccgctggac 16980cagggcaacc ccacccccag tctgaagccc gtgaccctgc agcaggtgct gccgagcagc 17040gcaccctccg aggcgaagcg gggtctgaag cgcgagggcg gcgacctggc gcccaccgtg 17100cagctcatgg tgcccaagcg gcagaggctg gaggatgtgc tggagaaaat gaaagtagac 17160cccggtctgc agccggacat cagggtccgc cccatcaagc aggtggcgcc gggcctcggc 17220gtgcagaccg tggacgtggt catccccacc ggcaactccc ccgccgccgc caccactacc 17280gctgcctcca cggacatgga gacacagacc gatcccgccg cagccgcagc cgcagccgcc 17340gccgcgacct cctcggcgga ggtgcagacg gacccctggc tgccgccggc gatgtcagct 17400ccccgcgcgc gtcgcgggcg caggaagtac ggcgccgcca acgcgctcct gcccgagtac 17460gccttgcatc cttccatcgc gcccaccccc ggctaccgag gctataccta ccgcccgcga 17520agagccaagg gttccacccg ccgtccccgc cgacgcgccg ccgccaccac ccgccgccgc 17580cgccgcagac gccagcccgc actggctcca gtctccgtga ggaaagtggc gcgcgacgga 17640cacaccctgg tgctgcccag ggcgcgctac caccccagca tcgtttaaaa gcctgttgtg 17700gttcttgcag atatggccct cacttgccgc ctccgtttcc cggtgccggg ataccgagga 17760ggaagatcgc gccgcaggag gggtctggcc ggccgcggcc tgagcggagg cagccgccgc 17820gcgcaccggc ggcgacgcgc caccagccga cgcatgcgcg gcggggtgct gcccctgtta 17880atccccctga tcgccgcggc gatcggcgcc gtgcccggga tcgcctccgt ggccttgcaa 17940gcgtcccaga ggcattgaca gacttgcaaa cttgcaaata tggaaaaaaa aaccccaata 18000aaaaagtcta gactctcacg ctcgcttggt cctgtgacta ttttgtagaa tggaagacat 18060caactttgcg tcgctggccc cgcgtcacgg ctcgcgcccg ttcctgggac actggaacga 18120tatcggcacc agcaacatga gcggtggcgc cttcagttgg ggctctctgt ggagcggcat 18180taaaagtatc gggtctgccg ttaaaaatta cggctcccgg gcctggaaca gcagcacggg 18240ccagatgttg agagacaagt tgaaagagca gaacttccag cagaaggtgg tggagggcct 18300ggcctccggc atcaacgggg tggtggacct ggccaaccag gccgtgcaga ataagatcaa 18360cagcagactg gacccccggc cgccggtgga ggaggtgccg ccggcgctgg agacggtgtc 18420ccccgatggg cgtggcgaga agcgcccgcg gcccgatagg gaagagacca ctctggtcac 18480gcagaccgat gagccgcccc cgtatgagga ggccctgaag caaggtctgc ccaccacgcg 18540gcccatcgcg cccatggcca ccggggtggt gggccgccac acccccgcca cgctggactt 18600gcctccgccc gccgatgtgc cgcagcagca gaaggcggca cagccgggcc cgcccgcgac 18660cgcctcccgt tcctccgccg gtcctctgcg ccgcgcggcc agcggccccc gcgggggggt 18720cgcgaggcac ggcaactggc agagcacgct gaacagcatc gtgggtctgg gggtgcggtc 18780cgtgaagcgc cgccgatgct actgaatagc ttagctaacg tgttgtatgt gtgtatgcgc 18840cctatgtcgc cgccagagga gctgctgagt cgccgccgtt cgcgcgccca ccaccaccgc 18900cactccgccc ctcaagatgg cgaccccatc gatgatgccg cagtggtcgt acatgcacat 18960ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagttcg cccgcgccac 19020cgagagctac ttcagcctga gtaacaagtt taggaacccc acggtggcgc ccacgcacga 19080tgtgaccacc gaccggtctc agcgcctgac gctgcggttc attcccgtgg accgcgagga 19140caccgcgtac tcgtacaagg cgcggttcac cctggccgtg ggcgacaacc gcgtgctgga 19200catggcctcc acctactttg acatccgcgg ggtgctggac cggggtccca ctttcaagcc 19260ctactctggc accgcctaca actccctggc ccccaagggc gctcccaact cctgcgagtg 19320ggagcaagag gaaactcagg cagttgaaga agcagcagaa gaggaagaag aagatgctga 19380cggtcaagct gaggaagagc aagcagctac caaaaagact catgtatatg ctcaggctcc 19440cctttctggc gaaaaaatta gtaaagatgg tctgcaaata ggaacggacg ctacagctac

19500agaacaaaaa cctatttatg cagaccctac attccagccc gaaccccaaa tcggggagtc 19560ccagtggaat gaggcagatg ctacagtcgc cggcggtaga gtgctaaaga aatctactcc 19620catgaaacca tgctatggtt cctatgcaag acccacaaat gctaatggag gtcagggtgt 19680actaacggca aatgcccagg gacagctaga atctcaggtt gaaatgcaat tcttttcaac 19740ttctgaaaac gcccgtaacg aggctaacaa cattcagccc aaattggtgc tgtatagtga 19800ggatgtgcac atggagaccc cggatacgca cctttcttac aagcccgcaa aaagcgatga 19860caattcaaaa atcatgctgg gtcagcagtc catgcccaac agacctaatt acatcggctt 19920cagagacaac tttatcggcc tcatgtatta caatagcact ggcaacatgg gagtgcttgc 19980aggtcaggcc tctcagttga atgcagtggt ggacttgcaa gacagaaaca cagaactgtc 20040ctaccagctc ttgcttgatt ccatgggtga cagaaccaga tacttttcca tgtggaatca 20100ggcagtggac agttatgacc cagatgttag aattattgaa aatcatggaa ctgaagacga 20160gctccccaac tattgtttcc ctctgggtgg cataggggta actgacactt accaggctgt 20220taaaaccaac aatggcaata acgggggcca ggtgacttgg acaaaagatg aaacttttgc 20280agatcgcaat gaaatagggg tgggaaacaa tttcgctatg gagatcaacc tcagtgccaa 20340cctgtggaga aacttcctgt actccaacgt ggcgctgtac ctaccagaca agcttaagta 20400caacccctcc aatgtggaca tctctgacaa ccccaacacc tacgattaca tgaacaagcg 20460agtggtggcc ccggggctgg tggactgcta catcaacctg ggcgcgcgct ggtcgctgga 20520ctacatggac aacgtcaacc ccttcaacca ccaccgcaat gcgggcctgc gctaccgctc 20580catgctcctg ggcaacgggc gctacgtgcc cttccacatc caggtgcccc agaagttctt 20640tgccatcaag aacctcctcc tcctgccggg ctcctacacc tacgagtgga acttcaggaa 20700ggatgtcaac atggtcctcc agagctctct gggtaacgat ctcagggtgg acggggccag 20760catcaagttc gagagcatct gcctctacgc caccttcttc cccatggccc acaacacggc 20820ctccacgctc gaggccatgc tcaggaacga caccaacgac cagtccttca atgactacct 20880ctccgccgcc aacatgctct accccatacc cgccaacgcc accaacgtcc ccatctccat 20940cccctcgcgc aactgggcgg ccttccgcgg ctgggccttc acccgcctca agaccaagga 21000gaccccctcc ctgggctcgg gattcgaccc ctactacacc tactcgggct ccattcccta 21060cctggacggc accttctacc tcaaccacac tttcaagaag gtctcggtca ccttcgactc 21120ctcggtcagc tggccgggca acgaccgtct gctcaccccc aacgagttcg agatcaagcg 21180ctcggtcgac ggggagggct acaacgtggc ccagtgcaac atgaccaagg actggttcct 21240ggtccagatg ctggccaact acaacatcgg ctaccagggc ttctacatcc cagagagcta 21300caaggacagg atgtactcct tcttcaggaa cttccagccc atgagccggc aggtggtgga 21360ccagaccaag tacaaggact accaggaggt gggcatcatc caccagcaca acaactcggg 21420cttcgtgggc tacctcgccc ccaccatgcg cgagggacag gcctaccccg ccaacttccc 21480ctatccgctc ataggcaaga ccgcggtcga cagcatcacc cagaaaaagt tcctctgcga 21540ccgcaccctc tggcgcatcc ccttctccag caacttcatg tccatgggtg cgctctcgga 21600cctgggccag aacttgctct acgccaactc cgcccacgcc ctcgacatga ccttcgaggt 21660cgaccccatg gacgagccca cccttctcta tgttctgttc gaagtctttg acgtggtccg 21720ggtccaccag ccgcaccgcg gcgtcatcga gaccgtgtac ctgcgtacgc ccttctcggc 21780cggcaacgcc accacctaaa gaagcaagcc gcagtcatcg ccgcctgcat gccgtcgggt 21840tccaccgagc aagagctcag ggccatcgtc agagacctgg gatgcgggcc ctattttttg 21900ggcaccttcg acaagcgctt ccctggcttt gtctccccac acaagctggc ctgcgccatc 21960gtcaacacgg ccggccgcga gaccgggggc gtgcactggc tggccttcgc ctggaacccg 22020cgctccaaaa catgcttcct ctttgacccc ttcggctttt cggaccagcg gctcaagcaa 22080atctacgagt tcgagtacga gggcttgctg cgtcgcagcg ccatcgcctc ctcgcccgac 22140cgctgcgtca ccctcgaaaa gtccacccag accgtgcagg ggcccgactc ggccgcctgc 22200ggtctcttct gctgcatgtt tctgcacgcc tttgtgcact ggcctcagag tcccatggac 22260cgcaacccca ccatgaactt gctgacgggg gtgcccaact ccatgctcca gagcccccag 22320gtcgagccca ccctgcgccg caaccaggag cagctctaca gcttcctgga gcgccactcg 22380ccttacttcc gccgccacag cgcacagatc aggagggcca cctccttctg ccacttgcaa 22440gagatgcaag aagggtaata acgatgtaca cacttttttt ctcaataaat ggcatctttt 22500tatttataca agctctctgg ggtattcatt tcccaccacc acccgccgtt gtcgccatct 22560ggctctattt agaaatcgaa agggttctgc cgggagtcgc cgtgcgccac gggcagggac 22620acgttgcgat actggtagcg ggtgccccac ttgaactcgg gcaccaccag gcgaggcagc 22680tcggggaagt tttcgctcca caggctgcgg gtcagcacca gcgcgttcat caggtcgggc 22740gccgagatct tgaagtcgca gttggggccg ccgccctgcg cgcgcgagtt gcggtacacc 22800gggttgcagc actggaacac caacagcgcc gggtgcttca cgctggccag cacgctgcgg 22860tcggagatca gctcggcgtc caggtcctcc gcgttgctca gcgcgaacgg ggtcatcttg 22920ggcacttgcc gccccaggaa gggcgcgtgc cccggtttcg agttgcagtc gcagcgcagc 22980gggatcagca ggtgcccgtg cccggactcg gcgttggggt acagcgcgcg catgaaggcc 23040tgcatctggc ggaaggccat ctgggccttg gcgccctccg agaagaacat gccgcaggac 23100ttgcccgaga actggtttgc ggggcagctg gcgtcgtgca ggcagcagcg cgcgtcggtg 23160ttggcgatct gcaccacgtt gcgcccccac cggttcttca cgatcttggc cttggacgat 23220tgctccttca gcgcgcgctg cccgttctcg ctggtcacat ccatctcgat cacatgttcc 23280ttgttcacca tgctgctgcc gtgcagacac ttcagctcgc cctccgtctc ggtgcagcgg 23340tgctgccaca gcgcgcagcc cgtgggctcg aaagacttgt aggtcacctc cgcgaaggac 23400tgcaggtacc cctgcaaaaa gcggcccatc atggtcacga aggtcttgtt gctgctgaag 23460gtcagctgca gcccgcggtg ctcctcgttc agccaggtct tgcacacggc cgccagcgcc 23520tccacctggt cgggcagcat cttgaagttc accttcagct cattctccac gtggtacttg 23580tccatcagcg tgcgcgccgc ctccatgccc ttctcccagg ccgacaccag cggcaggctc 23640acggggttct tcaccatcac cgtggccgcc gcctccgccg cgctttcgct ttccgccccg 23700ctgttctctt cctcttcctc ctcttcctcg ccgccgccca ctcgcagccc ccgcaccacg 23760gggtcgtctt cctgcaggcg ctgcaccttg cgcttgccgt tgcgcccctg cttgatgcgc 23820acgggcgggt tgctgaagcc caccatcacc agcgcggcct cttcttgctc gtcctcgctg 23880tccagaatga cctccgggga gggggggttg gtcatcctca gtaccgaggc acgcttcttt 23940ttcttcctgg gggcgttcgc cagctccgcg gctgcggccg ctgccgaggt cgaaggccga 24000gggctgggcg tgcgcggcac cagcgcgtcc tgcgagccgt cctcgtcctc ctcggactcg 24060agacggaggc gggcccgctt cttcgggggc gcgcggggcg gcggaggcgg cggcggcgac 24120ggagacgggg acgagacatc gtccagggtg ggtggacggc gggccgcgcc gcgtccgcgc 24180tcgggggtgg tctcgcgctg gtcctcttcc cgactggcca tctcccactg ctccttctcc 24240tataggcaga aagagatcat ggagtctctc atgcgagtcg agaaggagga ggacagccta 24300accgccccct ctgagccctc caccaccgcc gccaccaccg ccaatgccgc cgcggacgac 24360gcgcccaccg agaccaccgc cagtaccacc ctccccagcg acgcaccccc gctcgagaat 24420gaagtgctga tcgagcagga cccgggtttt gtgagcggag aggaggatga ggtggatgag 24480aaggagaagg aggaggtcgc cgcctcagtg ccaaaagagg ataaaaagca agaccaggac 24540gacgcagata aggatgagac agcagtcggg cgggggaacg gaagccatga tgctgatgac 24600ggctacctag acgtgggaga cgacgtgctg cttaagcacc tgcaccgcca gtgcgtcatc 24660gtctgcgacg cgctgcagga gcgctgcgaa gtgcccctgg acgtggcgga ggtcagccgc 24720gcctacgagc ggcacctctt cgcgccgcac gtgcccccca agcgccggga gaacggcacc 24780tgcgagccca acccgcgtct caacttctac ccggtcttcg cggtacccga ggtgctggcc 24840acctaccaca tctttttcca aaactgcaag atccccctct cctgccgcgc caaccgcacc 24900cgcgccgaca aaaccctgac cctgcggcag ggcgcccaca tacctgatat cgcctctctg 24960gaggaagtgc ccaagatctt cgagggtctc ggtcgcgacg agaaacgggc ggcgaacgct 25020ctgcacggag acagcgaaaa cgagagtcac tcgggggtgc tggtggagct cgagggcgac 25080aacgcgcgcc tggccgtact caagcgcagc atagaggtca cccactttgc ctacccggcg 25140ctcaacctgc cccccaaggt catgagtgtg gtcatgggcg agctcatcat gcgccgcgcc 25200cagcccctgg ccgcggatgc aaacttgcaa gagtcctccg aggaaggcct gcccgcggtc 25260agcgacgagc agctggcgcg ctggctggag acccgcgacc ccgcgcagct ggaggagcgg 25320cgcaagctca tgatggccgc ggtgctggtc accgtggagc tcgagtgtct gcagcgcttc 25380ttcgcggacc ccgagatgca gcgcaagctc gaggagaccc tgcactacac cttccgccag 25440ggctacgtgc gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac 25500ctgggcatcc tgcacgagaa ccgcctcggg cagaacgtcc tgcactccac cctcaaaggg 25560gaggcgcgcc gcgactacat ccgcgactgc gcctacctct tcctctgcta cacctggcag 25620acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga gctggaaaag 25680ctcctcaagc gcaccctcag ggacctctgg acgggcttca acgagcgctc ggtggccgcc 25740gcgctggcgg acatcatctt tcccgagcgc ctgctcaaga ccctgcagca gggcctgccc 25800gacttcacca gccagagcat gctgcagaac ttcaggactt tcatcctgga gcgctcgggc 25860atcctgccgg ccacttgctg cgcgctgccc agcgacttcg tgcccatcaa gtacagggag 25920tgcccgccgc cgctctgggg ccactgctac ctcttccagc tggccaacta cctcgcctac 25980cactcggacc tcatggaaga cgtgagcggc gagggcctgc tcgagtgcca ctgccgctgc 26040aacctctgca cgccccaccg ctctctagtc tgcaacccgc agctgctcag cgagagtcag 26100attatcggta ccttcgagct gcagggtccc tcgcctgacg agaagtccgc ggctccaggg 26160ctgaaactca ctccggggct gtggacttcc gcctacctac gcaaatttgt acctgaggac 26220taccacgccc acgagatcag gttctacgaa gaccaatccc gcccgcccaa ggcggagctc 26280accgcctgcg tcatcaccca ggggcacatc ctgggccaat tgcaagccat caacaaagcc 26340cgccgagagt tcttgctgaa aaagggtcgg ggggtgtacc tggaccccca gtccggcgag 26400gagctaaacc cgctaccccc gccgccgccc cagcagcggg accttgcttc ccaggatggc 26460acccagaaag aagcagcagc cgccgccgcc gccgcagcca tacatgcttc tggaggaaga 26520ggaggaggac tgggacagtc aggcagagga ggtttcggac gaggagcagg aggagatgat 26580ggaagactgg gaggaggaca gcagcctaga cgaggaagct tcagaggccg aagaggtggc 26640agacgcaaca ccatcgccct cggtcgcagc cccctcgccg gggcccctga aatcctccga 26700acccagcacc agcgctataa cctccgctcc tccggcgccg gcgccacccg cccgcagacc 26760caaccgtaga tgggacacca caggaaccgg ggtcggtaag tccaagtgcc cgccgccgcc 26820accgcagcag cagcagcagc agcgccaggg ctaccgctcg tggcgcgggc acaagaacgc 26880catagtcgcc tgcttgcaag actgcggggg caacatctct ttcgcccgcc gcttcctgct 26940attccaccac ggggtcgcct ttccccgcaa tgtcctgcat tactaccgtc atctctacag 27000cccctactgc agcggcgacc cagaggcggc agcggcagcc acagcggcga ccaccaccta 27060ggaagatatc ctccgcgggc aagacagcgg cagcagcggc caggagaccc gcggcagcag 27120cggcgggagc ggtgggcgca ctgcgcctct cgcccaacga acccctctcg acccgggagc 27180tcagacacag gatcttcccc actttgtatg ccatcttcca acagagcaga ggccaggagc 27240aggagctgaa aataaaaaac agatctctgc gctccctcac ccgcagctgt ctgtatcaca 27300aaagcgaaga tcagcttcgg cgcacgctgg aggacgcgga ggcactcttc agcaaatact 27360gcgcgctcac tcttaaagac tagctccgcg cccttctcga atttaggcgg gagaaaacta 27420cgtcatcgcc ggccgccgcc cagcccgccc agccgagatg agcaaagaga ttcccacgcc 27480atacatgtgg agctaccagc cgcagatggg actcgcggcg ggagcggccc aggactactc 27540cacccgcatg aactacatga gcgcgggacc ccacatgatc tcacaggtca acgggatccg 27600cgcccagcga aaccaaatac tgctggaaca ggcggccatc accgccacgc cccgccataa 27660tctcaacccc cgaaattggc ccgccgccct cgtgtaccag gaaaccccct ccgccaccac 27720cgtactactt ccgcgtgacg cccaggccga agtccagatg actaactcag gggcgcagct 27780cgcgggcggc tttcgtcacg gggcgcggcc gctccgacca ggtataagac acctgatgat 27840cagaggccga ggtatccagc tcaacgacga gtcggtgagc tcttcgctcg gtctccgtcc 27900ggacggaact ttccagctcg ccggatccgg ccgctcttcg ttcacgcccc gccaggcgta 27960cctgactctg cagacctcgt cctcggagcc ccgctccggc ggcatcggaa ccctccagtt 28020cgtggaggag ttcgtgccct cggtctactt caaccccttc tcgggacctc ccggacgcta 28080ccccgaccag ttcattccga actttgacgc ggtgaaggac tcggcggacg gctacgactg 28140aatgtcaggt gtcgaggcag agcagcttcg cctgagacac ctcgagcact gccgccgcca 28200caagtgcttc gcccgcggtt ctggtgagtt ctgctacttt cagctacccg aggagcatac 28260cgaggggccg gcgcacggcg tccgcctgac cacccagggc gaggttacct gttccctcat 28320ccgggagttt accctccgtc ccctgctagt ggagcgggag cggggtccct gtgtcctaac 28380tatcgcctgc aactgcccta accctggatt acatcaagat ctttgctgtc atctctgtgc 28440tgagtttaat aaacgctgag atcagaatct actggggctc ctgtcgccat cctgtgaacg 28500ccaccgtctt cacccacccc gaccaggccc aggcgaacct cacctgcggt ctgcatcgga 28560gggccaagaa gtacctcacc tggtacttca acggcacccc ctttgtggtt tacaacagct 28620tcgacgggga cggagtctcc ctgaaagacc agctctccgg tctcagctac tccatccaca 28680agaacaccac cctccaactc ttccctccct acctgccggg aacctacgag tgcgtcaccg 28740gccgctgcac ccacctcacc cgcctgatcg taaaccagag ctttccggga acagataact 28800ccctcttccc cagaacagga ggtgagctca ggaaactccc cggggaccag ggcggagacg 28860taccttcgac ccttgtgggg ttaggatttt ttattaccgg gttgctggct cttttaatca 28920aagtttcctt gagatttgtt ctttccttct acgtgtatga acacctcaac ctccaataac 28980tctacccttt cttcggaatc aggtgacttc tctgaaatcg ggcttggtgt gctgcttact 29040ctgttgattt ttttccttat catactcagc cttctgtgcc tcaggctcgc cgcctgctgc 29100gcacacatct atatctactg ctggttgctc aagtgcaggg gtcgccaccc aagatgaaca 29160ggtacatggt cctatcgatc ctaggcctgc tggccctggc ggcctgcagc gccgccaaaa 29220aagagattac ctttgaggag cccgcttgca atgtaacttt caagcccgag ggtgaccaat 29280gcaccaccct cgtcaaatgc gttaccaatc atgagaggct gcgcatcgac tacaaaaaca 29340aaactggcca gtttgcggtc tatagtgtgt ttacgcccgg agacccctct aactactctg 29400tcaccgtctt ccagggcgga cagtctaaga tattcaatta cactttccct ttttatgagt 29460tatgcgatgc ggtcatgtac atgtcaaaac agtacaacct gtggcctccc tctccccagg 29520cgtgtgtgga aaatactggg tcttactgct gtatggcttt cgcaatcact acgctcgctc 29580taatctgcac ggtgctatac ataaaattca ggcagaggcg aatctttatc gatgaaaaga 29640aaatgccttg atcgctaaca ccggctttct atctgcagaa tgaatgcaat cacctcccta 29700ctaatcacca ccaccctcct tgcgattgcc catgggttga cacgaatcga agtgccagtg 29760gggtccaatg tcaccatggt gggccccgcc ggcaattcca ccctcatgtg ggaaaaattt 29820gtccgcaatc aatgggttca tttctgctct aaccgaatca gtatcaagcc cagagccatc 29880tgcgatgggc aaaatctaac tctgatcaat gtgcaaatga tggatgctgg gtactattac 29940gggcagcggg gagaaatcat taattactgg cgaccccaca aggactacat gctgcatgta 30000gtcgaggcac ttcccactac cacccccact accacctctc ccaccaccac caccactact 30060actactacta ctactactac tactactacc actaccgctg cccgccatac ccgcaaaagc 30120accatgatta gcacaaagcc ccctcgtgct cactcccacg ccggcgggcc catcggtgcg 30180acctcagaaa ccaccgagct ttgcttctgc caatgcacta acgccagcgc tcatgaactg 30240ttcgacctgg agaatgagga tgtccagcag agctccgctt gcctgaccca ggaggctgtg 30300gagcccgttg ccctgaagca gatcggtgat tcaataattg actcttcttc ttttgccact 30360cccgaatacc ctcccgattc tactttccac atcacgggta ccaaagaccc taacctctct 30420ttctacctga tgctgctgct ctgtatctct gtggtctctt ccgcgctgat gttactgggg 30480atgttctgct gcctgatctg ccgcagaaag agaaaagctc gctctcaggg ccaaccactg 30540atgcccttcc cctacccccc ggattttgca gataacaaga tatgagctcg ctgctgacac 30600taaccgcttt actagcctgc gctctaaccc ttgtcgcttg cgactcgaga ttccacaatg 30660tcacagctgt ggcaggagaa aatgttactt tcaactccac ggccgatacc cagtggtcgt 30720ggagtggctc aggtagctac ttaactatct gcaatagctc cacttccccc ggcatatccc 30780caaccaagta ccaatgcaat gccagcctgt tcaccctcat caacgcttcc accctggaca 30840atggactcta tgtaggctat gtaccctttg gtgggcaagg aaagacccac gcttacaacc 30900tggaagttcg ccagcccaga accactaccc aagcttctcc caccaccacc accaccacca 30960ccatcaccag cagcagcagc agcagcagcc acagcagcag cagcagatta ttgactttgg 31020ttttggccag ctcatctgcc gctacccagg ccatctacag ctctgtgccc gaaaccactc 31080agatccaccg cccagaaacg accaccgcca ccaccctaca cacctccagc gatcagatgc 31140cgaccaacat cacccccttg gctcttcaaa tgggacttac aagccccact ccaaaaccag 31200tggatgcggc cgaggtctcc gccctcgtca atgactgggc ggggctggga atgtggtggt 31260tcgccatagg catgatggcg ctctgcctgc ttctgctctg gctcatctgc tgcctccacc 31320gcaggcgagc cagacccccc atctatagac ccatcattgt cctgaacccc gataatgatg 31380ggatccatag attggatggc ctgaaaaacc tacttttttc ttttacagta tgataaattg 31440agacatgcct cgcattttct tgtacatgtt ccttctccca ccttttctgg ggtgttctac 31500gctggccgct gtgtctcacc tggaggtaga ctgcctctca cccttcactg tctacctgct 31560ttacggattg gtcaccctca ctctcatctg cagcctaatc acagtaatca tcgccttcat 31620ccagtgcatt gattacatct gtgtgcgcct cgcatacttc agacaccacc cgcagtaccg 31680agacaggaac attgcccaac ttctaagact gctctaatca tgcataagac tgtgatctgc 31740cttctgatcc tctgcatcct gcccaccctc acctcctgcc agtacaccac aaaatctccg 31800cgcaaaagac atgcctcctg ccgcttcacc caactgtgga atatacccaa atgctacaac 31860gaaaagagcg agctctccga agcttggctg tatggggtca tctgtgtctt agttttctgc 31920agcactgtct ttgccctcat aatctacccc tactttgatt tgggatggaa cgcgatcgat 31980gccatgaatt accccacctt tcccgcaccc gagataattc cactgcgaca agttgtaccc 32040gttgtcgtta atcaacgccc cccatcccct acgcccactg aaatcagcta ctttaaccta 32100acaggcggag atgactgacg ccctagatct agaaatggac ggcatcagta ccgagcagcg 32160tctcctagag aggcgcaggc aggcggctga gcaagagcgc ctcaatcagg agctccgaga 32220tctcgttaac ctgcaccagt gcaaaagagg catcttttgt ctggtaaagc aggccaaagt 32280cacctacgag aagaccggca acagccaccg cctcagttac aaattgccca cccagcgcca 32340gaagctggtg ctcatggtgg gtgagaatcc catcaccgtc acccagcact cggtagagac 32400cgaggggtgt ctgcactccc cctgtcgggg tccagaagac ctctgcaccc tggtaaagac 32460cctgtgcggt ctcagagatt tagtcccctt taactaatca aacactggaa tcaataaaaa 32520gaatcactta cttaaaatca gacagcaggt ctctgtccag tttattcagc agcacctcct 32580tcccctcctc ccaactctgg tactccaaac gccttctggc ggcaaacttc ctccacaccc 32640tgaagggaat gtcagattct tgctcctgtc cctccgcacc cactatcttc atgttgttgc 32700agatgaagcg caccaaaacg tctgacgaga gcttcaaccc cgtgtacccc tatgacacgg 32760aaagcggccc tccctccgtc cctttcctca cccctccctt cgtgtctccc gatggattcc 32820aagaaagtcc ccccggggtc ctgtctctga acctggccga gcccctggtc acttcccacg 32880gcatgctcgc cctgaaaatg ggaagtggcc tctccctgga cgacgctggc aacctcacct 32940ctcaagatat caccaccgct agccctcccc tcaaaaaaac caagaccaac ctcagcctag 33000aaacctcatc ccccctaact gtgagcacct caggcgccct caccgtagca gccgccgctc 33060ccctggcggt ggccggcacc tccctcacca tgcaatcaga ggcccccctg acagtacagg 33120atgcaaaact caccctggcc accaaaggcc ccctgaccgt gtctgaaggc aaactggcct 33180tgcaaacatc ggccccgctg acggccgctg acagcagcac cctcacagtc agtgccacac 33240caccccttag cacaagcaat ggcagcttgg gtattgacat gcaagccccc atttacacca 33300ccaatggaaa actaggactt aactttggcg ctcccctgca tgtggtagac agcctaaatg 33360cactgactgt agttactggc caaggtctta cgataaacgg aacagcccta caaactagag 33420tctcaggtgc cctcaactat gacacatcag gaaacctaga attgagagct gcagggggta 33480tgcgagttga tgcaaatggt caacttatcc ttgatgtagc ttacccattt gatgcacaaa 33540acaatctcag ccttaggctt ggacagggac ccctgtttgt taactctgcc cacaacttgg 33600atgttaacta caacagaggc ctctacctgt tcacatctgg aaataccaaa aagctagaag 33660ttaatatcaa aacagccaag ggtctcattt atgatgacac tgctatagca atcaatgcgg 33720gtgatgggct acagtttgac tcaggctcag atacaaatcc attaaaaact aaacttggat 33780taggactgga ttatgactcc agcagagcca taattgctaa actgggaact ggcctaagct 33840ttgacaacac aggtgccatc acagtaggca acaaaaatga tgacaagctt accttgtgga 33900ccacaccaga cccatcccct aactgtagaa tctattcaga gaaagatgct aaattcacac 33960ttgttttgac taaatgcggc agtcaggtgt tggccagcgt ttctgtttta tctgtaaaag 34020gtagccttgc gcccatcagt ggcacagtaa ctagtgctca gattgtcctc agatttgatg 34080aaaatggagt tctactaagc aattcttccc ttgaccctca atactggaac tacagaaaag 34140gtgaccttac agagggcact gcatatacca acgcagtggg atttatgccc aacctcacag 34200catacccaaa aacacagagc caaactgcta aaagcaacat tgtaagtcag gtttacttga 34260atggggacaa atccaaaccc atgaccctca ccattaccct caatggaact aatgaaacag 34320gagatgccac agtaagcact tactccatgt cattctcatg gaactggaat ggaagtaatt 34380acattaatga aacgttccaa accaactcct tcaccttctc ctacatcgcc caagaataaa 34440aagcatgacg ctgttgattt gattcaatgt gtttctgttt tattttcaag cacaacaaaa 34500tcattcaagt cattcttcca tcttagctta atagacacag tagcttaata gacccagtag

34560tgcaaagccc cattctagct tatagatcag acagtgataa ttaaccacca ccaccaccat 34620accttttgat tcaggaaatc atgatcatca caggatccta gtcttcaggc cgccccctcc 34680ctcccaagac acagaataca cagtcctctc cccccgactg gctttaaata acaccatctg 34740gttggtcaca gacatgttct taggggttat attccacacg gtctcctgcc gcgccaggcg 34800ctcgtcggtg atgttgataa actctcccgg cagctcgctc aagttcacgt cgctgtccag 34860cggctgaacc tccggctgac gcgataactg tgcgaccggc tgctggacga acggaggccg 34920cgcctacaag ggggtagagt cataatcctc ggtcaggata gggcggtgat gcagcagcag 34980cgagcgaaac atctgctgcc gccgccgctc cgtccggcag gaaaacaaca cgccggtggt 35040ctcctccgcg ataatccgca ccgcccgcag catcagcttc ctcgttctcc gcgcgcagca 35100cctcaccctt atctcgctca aatcggcgca gtaggtacag cacagcacca cgatgttatt 35160catgatccca cagtgcaggg cgctgtatcc aaagctcatg ccgggaacca ccgcccccac 35220gtggccatcg taccacaagc gcacgtaaat caagtgtcga cccctcatga acgcgctgga 35280cacaaacatt acttccttgg gcatgttgta attcaccacc tcccggtacc agataaacct 35340ctggttgaac agggcacctt ccaccaccat cctgaaccaa gaggccagaa cctgcccacc 35400ggctatgcac tgcagggaac ccgggttgga acaatgacaa tgcagactcc aaggctcgta 35460accgtggatc atccggctgc tgaaggcatc gatgttggca caacacagac acacgtgcat 35520gcactttctc atgattagca gctcttccct cgtcaggatc atatcccaag gaataaccca 35580ttcttgaatc aacgtaaaac ccacacagca gggaaggcct cgcacataac tcacgttgtg 35640catggtcagc gtgttgcatt ccggaaacag cggatgatcc tccagtatcg aggcgcgggt 35700ctccttctca cagggaggta aagggtccct gctgtacgga ctgcgccggg acgaccgaga 35760tcgtgttgag cgtagtgtca tggaaaaggg aacgccggac gtggtcatac ttcttgaagc 35820agaaccaggt tcgcgcgtgg caggcctcct tgcgtctgcg gtctcgccgt ctagctcgct 35880ccgtgtgata gttgtagtac agccactccc gcagagcgtc gaggcgcacc ctggcttccg 35940gatctatgta gactccgtct tgcaccgcgg ccctgataat atccaccacc gtagaataag 36000caacacccag ccaagcaata cactcgctct gcgagcggca gacaggagga gcgggcagag 36060atgggagaac catgataaaa aacttttttt aaagaatatt ttccaattct tcgaaagtaa 36120gatctatcaa gtggcagcgc tcccctccac tggcgcggtc aaactctacg gccaaagcac 36180agacaacggc atttctaaga tgttccttaa tggcgtccaa aagacacacc gctctcaagt 36240tgcagtaaac tatgaatgaa aacccatccg gctgattttc caatatagac gcgccggcag 36300cgtccaccaa acccagataa ttttcttctc tccagcggtt tacgatctgt ctaagcaaat 36360cccttatatc aagtccgacc atgccaaaaa tctgctcaag agcgccctcc accttcatgt 36420acaagcagcg catcatgatt gcaaaaattc aggttcttca gagacctgta taagattcaa 36480aatgggaaca ttaacaaaaa ttcctctgtc gcgcagatcc cttcgcaggg caagctgaac 36540ataatcagac aggtccgaac ggaccagtga ggccaaatcc ccaccaggaa ccagatccag 36600agaccctata ctgattatga cgcgcatact cggggctatg ctgaccagcg tagcgccgat 36660gtaggcgtgc tgcatgggcg gcgagataaa atgcaaagtg ctggttaaaa aatcaggcaa 36720agcctcgcgc aaaaaagcta acacatcata atcatgctca tgcaggtagt tgcaggtaag 36780ctcaggaacc aaaacggaat aacacacgat tttcctctca aacatgactt cgcggatact 36840gcgtaaaaca aaaaattata aataaaaaat taattaaata acttaaacat tggaagcctg 36900tctcacaaca ggaaaaacca ctttaatcaa cataagacgg gccacgggca tgccggcata 36960gccgtaaaaa aattggtccc cgtgattaac aagtaccaca gacagctccc cggtcatgtc 37020gggggtcatc atgtgagact ctgtatacac gtctggattg tgaacatcag acaaacaaag 37080aaatcgagcc acgtagcccg gaggtataat cacccgcagg cggaggtaca gcaaaacgac 37140ccccatagga ggaatcacaa aattagtagg agaaaaaaat acataaacac cagaaaaacc 37200ctgttgctga ggcaaaatag cgccctcccg atccaaaaca acataaagcg cttccacagg 37260agcagccata acaaagaccc gagtcttacc agtaaaagaa aaaagatctc tcaacgcagc 37320accagcacca acacttcgca gtgtaaaagg ccaagtgccg agagagtata tataggaata 37380aaaagtgacg taaacgggca aagtccaaaa aacgcccaga aaaaccgcac gcgaacctac 37440gccccgaaac gaaagccaaa aaacactaga cactcccttc cggcgtcaac ttccgctttc 37500ccacgctacg tcacttgccc cagtcaaaca aactacatat cccgaacttc caagtcgcca 37560cgcccaaaac accgcctaca cctccccgcc cgccggcccg cccccaaacc cgcctcccgc 37620cccgcgcccc gccccgcgcc gcccatctca ttatcatatt ggcttcaatc caaaataagg 37680tatattattg atgatggttt aaacggatcc tctagagtcg acctgcaggc atgcaagctt 37740gagtattcta tagtgtcacc taaatagctt ggcgtaatca tggtcatagc tgtttcctgt 37800gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa 37860agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc 37920tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgaacccct 37980tgcggccgcc cgggccgtcg accaattctc atgtttgaca gcttatcatc gaatttctgc 38040cattcatccg cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat 38100aactgcctta aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat 38160taagcattct gccgacatgg aagccatcac aaacggcatg atgaacctga atcgccagcg 38220gcatcagcac cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga 38280agttgtccat attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg 38340agacgaaaaa catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac 38400acgccacatc ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc 38460agagcgatga aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat 38520cccatatcac cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca 38580ggcgggcaag aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct 38640ttaaaaaggc cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact 38700gaaatgcctc aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag 38760tgattttttt ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata 38820cgcccggtag tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa 38880cgtctcattt tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat 38940ttatttattc tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag 39000cggcgtaacc gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga 39060acggtcagga cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc 39120tctgttccgg tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc 39180ggtataccgc tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa 39240gtctacacga aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg 39300ccggagtctg atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct 39360ttatatggaa atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg 39420gctgttatcc actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat 39480ccgcattatt aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat 39540gcctgcaagc ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt 39600gcggtgttac gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac 39660acagaaccat gatgtggtct gtccttttac agccagtagt gctcgccgca gtcgagcgac 39720agggcgaagc cctcgagtga gcgaggaagc accagggaac agcacttata tattctgctt 39780acacacgatg cctgaaaaaa cttcccttgg ggttatccac ttatccacgg ggatattttt 39840ataattattt tttttatagt ttttagatct tcttttttag agcgccttgt aggcctttat 39900ccatgctggt tctagagaag gtgttgtgac aaattgccct ttcagtgtga caaatcaccc 39960tcaaatgaca gtcctgtctg tgacaaattg cccttaaccc tgtgacaaat tgccctcaga 40020agaagctgtt ttttcacaaa gttatccctg cttattgact cttttttatt tagtgtgaca 40080atctaaaaac ttgtcacact tcacatggat ctgtcatggc ggaaacagcg gttatcaatc 40140acaagaaacg taaaaatagc ccgcgaatcg tccagtcaaa cgacctcact gaggcggcat 40200atagtctctc ccgggatcaa aaacgtatgc tgtatctgtt cgttgaccag atcagaaaat 40260ctgatggcac cctacaggaa catgacggta tctgcgagat ccatgttgct aaatatgctg 40320aaatattcgg attgacctct gcggaagcca gtaaggatat acggcaggca ttgaagagtt 40380tcgcggggaa ggaagtggtt ttttatcgcc ctgaagagga tgccggcgat gaaaaaggct 40440atgaatcttt tccttggttt atcaaacgtg cgcacagtcc atccagaggg ctttacagtg 40500tacatatcaa cccatatctc attcccttct ttatcgggtt acagaaccgg tttacgcagt 40560ttcggcttag tgaaacaaaa gaaatcacca atccgtatgc catgcgttta tacgaatccc 40620tgtgtcagta tcgtaagccg gatggctcag gcatcgtctc tctgaaaatc gactggatca 40680tagagcgtta ccagctgcct caaagttacc agcgtatgcc tgacttccgc cgccgcttcc 40740tgcaggtctg tgttaatgag atcaacagca gaactccaat gcgcctctca tacattgaga 40800aaaagaaagg ccgccagacg actcatatcg tattttcctt ccgcgatatc acttccatga 40860cgacaggata gtctgagggt tatctgtcac agatttgagg gtggttcgtc acatttgttc 40920tgacctactg agggtaattt gtcacagttt tgctgtttcc ttcagcctgc atggattttc 40980tcatactttt tgaactgtaa tttttaagga agccaaattt gagggcagtt tgtcacagtt 41040gatttccttc tctttccctt cgtcatgtga cctgatatcg ggggttagtt cgtcatcatt 41100gatgagggtt gattatcaca gtttattact ctgaattggc tatccgcgtg tgtacctcta 41160cctggagttt ttcccacggt ggatatttct tcttgcgctg agcgtaagag ctatctgaca 41220gaacagttct tctttgcttc ctcgccagtt cgctcgctat gctcggttac acggctgcgg 41280cgagcgctag tgataataag tgactgaggt atgtgctctt cttatctcct tttgtagtgt 41340tgctcttatt ttaaacaact ttgcggtttt ttgatgactt tgcgattttg ttgttgcttt 41400gcagtaaatt gcaagattta ataaaaaaac gcaaagcaat gattaaagga tgttcagaat 41460gaaactcatg gaaacactta accagtgcat aaacgctggt catgaaatga cgaaggctat 41520cgccattgca cagtttaatg atgacagccc ggaagcgagg aaaataaccc ggcgctggag 41580aataggtgaa gcagcggatt tagttggggt ttcttctcag gctatcagag atgccgagaa 41640agcagggcga ctaccgcacc cggatatgga aattcgagga cgggttgagc aacgtgttgg 41700ttatacaatt gaacaaatta atcatatgcg tgatgtgttt ggtacgcgat tgcgacgtgc 41760tgaagacgta tttccaccgg tgatcggggt tgctgcccat aaaggtggcg tttacaaaac 41820ctcagtttct gttcatcttg ctcaggatct ggctctgaag gggctacgtg ttttgctcgt 41880ggaaggtaac gacccccagg gaacagcctc aatgtatcac ggatgggtac cagatcttca 41940tattcatgca gaagacactc tcctgccttt ctatcttggg gaaaaggacg atgtcactta 42000tgcaataaag cccacttgct ggccggggct tgacattatt ccttcctgtc tggctctgca 42060ccgtattgaa actgagttaa tgggcaaatt tgatgaaggt aaactgccca ccgatccaca 42120cctgatgctc cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga 42180cagcgcgcct aacctgggta tcggcacgat taatgtcgta tgtgctgctg atgtgctgat 42240tgttcccacg cctgctgagt tgtttgacta cacctccgca ctgcagtttt tcgatatgct 42300tcgtgatctg ctcaagaacg ttgatcttaa agggttcgag cctgatgtac gtattttgct 42360taccaaatac agcaatagta atggctctca gtccccgtgg atggaggagc aaattcggga 42420tgcctgggga agcatggttc taaaaaatgt tgtacgtgaa acggatgaag ttggtaaagg 42480tcagatccgg atgagaactg tttttgaaca ggccattgat caacgctctt caactggtgc 42540ctggagaaat gctctttcta tttgggaacc tgtctgcaat gaaattttcg atcgtctgat 42600taaaccacgc tgggagatta gataatgaag cgtgcgcctg ttattccaaa acatacgctc 42660aatactcaac cggttgaaga tacttcgtta tcgacaccag ctgccccgat ggtggattcg 42720ttaattgcgc gcgtaggagt aatggctcgc ggtaatgcca ttactttgcc tgtatgtggt 42780cgggatgtga agtttactct tgaagtgctc cggggtgata gtgttgagaa gacctctcgg 42840gtatggtcag gtaatgaacg tgaccaggag ctgcttactg aggacgcact ggatgatctc 42900atcccttctt ttctactgac tggtcaacag acaccggcgt tcggtcgaag agtatctggt 42960gtcatagaaa ttgccgatgg gagtcgccgt cgtaaagctg ctgcacttac cgaaagtgat 43020tatcgtgttc tggttggcga gctggatgat gagcagatgg ctgcattatc cagattgggt 43080aacgattatc gcccaacaag tgcttatgaa cgtggtcagc gttatgcaag ccgattgcag 43140aatgaatttg ctggaaatat ttctgcgctg gctgatgcgg aaaatatttc acgtaagatt 43200attacccgct gtatcaacac cgccaaattg cctaaatcag ttgttgctct tttttctcac 43260cccggtgaac tatctgcccg gtcaggtgat gcacttcaaa aagcctttac agataaagag 43320gaattactta agcagcaggc atctaacctt catgagcaga aaaaagctgg ggtgatattt 43380gaagctgaag aagttatcac tcttttaact tctgtgctta aaacgtcatc tgcatcaaga 43440actagtttaa gctcacgaca tcagtttgct cctggagcga cagtattgta taagggcgat 43500aaaatggtgc ttaacctgga caggtctcgt gttccaactg agtgtataga gaaaattgag 43560gccattctta aggaacttga aaagccagca ccctgatgcg accacgtttt agtctacgtt 43620tatctgtctt tacttaatgt cctttgttac aggccagaaa gcataactgg cctgaatatt 43680ctctctgggc ccactgttcc acttgtatcg tcggtctgat aatcagactg ggaccacggt 43740cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg 43800tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgata atcagactgg 43860gaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccatg gtcccactcg 43920tatcgtcggt ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgatta 43980ttagtctgga accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg 44040tcccactcgt atcgtcggtc tgattattag tctgggacca cgatcccact cgtgttgtcg 44100gtctgattat cggtctggga ccacggtccc acttgtattg tcgatcagac tatcagcgtg 44160agactacgat tccatcaatg cctgtcaagg gcaagtattg acatgtcgtc gtaacctgta 44220gaacggagta acctcggtgt gcggttgtat gcctgctgtg gattgctgct gtgtcctgct 44280tatccacaac attttgcgca cggttatgtg gacaaaatac ctggttaccc aggccgtgcc 44340ggcacgttaa ccgggctgca tccgatgcaa gtgtgtcgct gtcgacgagc tcgcgagctc 44400ggacatgagg ttgccccgta ttcagtgtcg ctgatttgta ttgtctgaag ttgtttttac 44460gttaagttga tgcagatcaa ttaatacgat acctgcgtca taattgatta tttgacgtgg 44520tttgatggcc tccacgcacg ttgtgatatg tagatgataa tcattatcac tttacgggtc 44580ctttccggtg atccgacagg ttacggggcg gcgacctcgc gggttttcgc tatttatgaa 44640aattttccgg tttaaggcgt ttccgttctt cttcgtcata acttaatgtt tttatttaaa 44700ataccctctg aaaagaaagg aaacgacagg tgctgaaagc gagctttttg gcctctgtcg 44760tttcctttct ctgtttttgt ccgtggaatg aacaatggaa gtccgagctc atcgctaata 44820acttcgtata gcatacatta tacgaagtta tattcgatgc ggccgcaagg ggttcgcgtc 44880agcgggtgtt ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact 44940gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat 45000caggcgccat tcgccattca ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc 45060ttcgctatta cgccagctgg cgaaaggggg atgtgctgca aggcgattaa gttgggtaac 45120gccagggttt tcccagtcac gacgttgtaa aacgacggcc agtgaattgt aatacgactc 45180actatagggc gaattcgagc tcggtacccg gggatcctcg tttaaac 452271037830DNASimian adenovirus 10catcatcaat aatatacctt attttggatt gaagccaata tgataatgag atgggcggcg 60cggggcggga ggcgggtccg ggggcgggcc ggcgggcggg gcggtgtggc ggaagtggac 120tttgtaagtg tggcggatgt gacttgctag tgccgggcgc ggtaaaagtg acgttttccg 180tgcgcgacaa cgcccacggg aagtgacatt tttcccgcgg tttttaccgg atgttgtagt 240gaatttgggc gtaaccaagt aagatttggc cattttcgcg ggaaaactga aacggggaag 300tgaaatctga ttaatttcgc gttagtcata ccgcgtaata tttgtcgagg gccgagggac 360tttggccgat tacgtggagg actcgcccag gtgttttttg aggtgaattt ccgcgttccg 420ggtcaaagtc tccgttttat tattatagtc agctgacgcg gagtgtattt ataccctctg 480atctcgtcaa gtggccactc ttgagtgcca gcgagtagag ttttctcctc tgccgctctc 540cgctccgctc cgctcggctc tgacaccggg gaaaaaatga gacatttcac ctacgatggc 600ggtgtgctca ccggccagct ggctgctgaa gtcctggaca ccctgatcga ggaggtattg 660gccgataatt atcctccctc gactcctttt gagccaccta cacttcacga actctacgat 720ctggatgtgg tggggcccag cgatccgaac gagcaggcgg tttccagttt ttttccagag 780tccatgttgt tggccagcca ggagggggtc gaacttgaga cccctcctcc gatcgtggat 840tcccccgatc cgccgcagct gactaggcag cccgagcgct gtgcgggacc tgagactatg 900ccccagctgc tacctgaggt gatcgatctc acctgtaatg agtctggttt tccacccagc 960gaggatgagg acgaagaggg tgagcagttt gtgttagatt ctgtggaaca acccgggcga 1020ggatgcaggt cttgtcaata tcaccggaaa aacacaggag actcccagat tatgtgttct 1080ctgtgttata tgaagatgac ctgtatgttt atttacagta agtttatcat ctgtgggcag 1140gtgggctata gtgtgggtgg tggtctttgg ggggtttttt aatatatgtc aggggttatg 1200ctgaagactt ttttattgtg atttttaaag gtccagtgtc tgagcccgag caagaacctg 1260aaccggagcc tgagccttct cgccccagga gaaagcctgt aatcttaact agacccagcg 1320caccggtagc gagaggcctc agcagcgcgg agaccaccga ctccggtgct tcctcatcac 1380ccccggagat tcaccccctg gtgcccctgt gtcccgttaa gcccgttgcc gtgagagtca 1440gtgggcggcg gtctgctgtg gagtgcattg aggacttgct ttttgattca caggaacctt 1500tggacttgag cttgaaacgc cccaggcatt aaacctggtc acctggactg aatgagttga 1560cgcctatgtt tgcttttgaa tgacttaatg tgtatagata ataaagagtg agataatgtt 1620ttaattgcat ggtgtgttta acttgggcgg agtctgctgg gtatataagc ttccctgggc 1680taaacttggt tacacttgac ctcatggagg cctgggagtg tttggagaac tttgccggag 1740ttcgtgcctt gctggacgag agctctaaca atacctcttg gtggtggagg tatttgtggg 1800gctctcccca gggcaagtta gtttgtagaa tcaaggagga ttacaagtgg gaatttgaag 1860agcttttgaa atcctgtggt gagctattgg attctttgaa tctaggccac caggctctct 1920tccaggagaa ggtcatcagg actttggatt tttccacacc ggggcgcatt gcagccgcgg 1980ttgcttttct agcttttttg aaggatagat ggagcgaaga gacccacttg agttcgggct 2040acgtcctgga ttttctggcc atgcaactgt ggagagcatg gatcagacac aagaacaggc 2100tgcaactgtt gtcttccgtc cgcccgttgc tgattccggc ggaggagcaa caggccgggt 2160cagaggaccg ggcccgtcgg gatccggagg agagggcacc gaggccgggc gagaggagcg 2220cgctgaacct gggaaccggg ctgagcggcc atccacatcg ggagtgaatg tcgggcaggt 2280ggtggatctt tttccagaac tgcggcggat tttgactatt agggaggatg ggcaatttgt 2340taagggtctt aagagggaga ggggggcttc tgagcataac gaggaggcca gtaatttagc 2400ttttagcttg atgaccagac accgtccaga gtgcatcact tttcagcaga ttaaggacaa 2460ttgtgccaat gagttggatc tgttgggtca gaagtatagc atagagcagc tgaccactta 2520ctggctgcag ccgggtgatg atctggagga agctattagg gtgtatgcta aggtggccct 2580gcggcccgat tgcaagtaca agctcaaggg gctggtgaat atcaggaatt gttgctacat 2640ttctggcaac ggggcggagg tggagataga gaccgaagac agggtggctt tcagatgcag 2700catgatgaat atgtggccgg gggtgctggg catggacggg gtggtgatta tgaatgtgag 2760gttcacgggg cccaacttta acggcacggt gtttttgggg aacaccaacc tggtcctgca 2820cggggtgagc ttctatgggt ttaacaacac ctgtgtggag gcctggaccg atgtgaaggt 2880ccgcggttgc gccttttatg gatgttggaa ggccatagtg agccgcccta agagcaggag 2940ttccattaag aaatgcttgt ttgagaggtg caccttgggg atcctggccg agggcaactg 3000cagggtgcgc cacaatgtgg cctccgagtg cggttgcttc atgctagtca agagcgtggc 3060ggtaatcaag cataatatgg tgtgcggcaa cagcgaggac aaggcctcac agatgctgac 3120ctgcacggat ggcaactgcc acttgctgaa gaccatccat gtaaccagcc acagccggaa 3180ggcctggccc gtgttcgagc acaacttgct gacccgctgc tccttgcatc tgggcaacag 3240gcggggggtg ttcctgccct atcaatgcaa ctttagtcac accaagatct tgctagagcc 3300cgagagcatg tccaaggtga acttgaacgg ggtgtttgac atgaccatga agatctggaa 3360ggtgctgagg tacgacgaga ccaggtcccg gtgcagaccc tgcgagtgcg ggggcaagca 3420tatgaggaac cagcccgtga tgctggatgt gaccgaggag ctgaggacag accacttggt 3480tctggcctgc accagggccg agtttggttc tagcgatgaa gacacagatt gaggtgggtg 3540agtgggcgtg gcctggggtg gtcatgaaaa tatataagtt gggggtctta gggtctcttt 3600atttgtgttg cagagaccgc cggagccatg agcgggagca gcagcagcag cagtagcagc 3660agcgccttgg atggcagcat cgtgagccct tatttgacga cgcggatgcc ccactgggcc 3720ggggtgcgtc agaatgtgat gggctccagc atcgacggcc gacccgtcct gcccgcaaat 3780tccgccacgc tgacctatgc gaccgtcgcg gggacgccgt tggacgccac cgccgccgcc 3840gccgccaccg cagccgcctc ggccgtgcgc agcctggcca cggactttgc attcctggga 3900ccactggcga caggggctac ttctcgggcc gctgctgccg ccgttcgcga tgacaagctg 3960accgccctgc tggcgcagtt ggatgcgctt actcgggaac tgggtgacct ttctcagcag 4020gtcatggccc tgcgccagca ggtctcctcc ctgcaagctg gcgggaatgc ttctcccaca 4080aatgccgttt aagataaata aaaccagact ctgtttggat taaagaaaag tagcaagtgc 4140attgctctct ttatttcata attttccgcg cgcgataggc cctagaccag cgttctcggt 4200cgttgagggt gcggtgtatc ttctccagga cgtggtagag gtggctctgg acgttgagat 4260acatgggcat gagcccgtcc cgggggtgga ggtagcacca ctgcagagct tcatgctccg 4320gggtggtgtt gtagatgatc cagtcgtagc

aggagcgctg ggcatggtgc ctaaaaatgt 4380ccttcagcag caggccgatg gccaggggga ggcccttggt gtaagtgttt acaaaacggt 4440taagttggga agggtgcatt cggggagaga tgatgtgcat cttggactgt atttttagat 4500tggcgatgtt tccgcccaga tcccttctgg gattcatgtt gtgcaggacc accagtacag 4560tgtatccggt gcacttgggg aatttgtcat gcagcttaga gggaaaagcg tggaagaact 4620tggagacgcc tttgtggcct cccagatttt ccatgcattc gtccatgatg atggcaatgg 4680gcccgcggga ggcagcttgg gcaaagatat ttctggggtc gctgacgtcg tagttgtgtt 4740ccagggtgag gtcgtcatag gccattttta caaagcgcgg gcggagggtg cccgactggg 4800ggatgatggt cccctctggc cctggggcgt agttgccctc gcagatctgc atttcccagg 4860ccttaatctc ggagggggga atcatatcca cctgcggggc gatgaagaaa acggtttccg 4920gagccgggga gattaactgg gatgagagca ggtttctaag cagctgtgat tttccacaac 4980cggtgggccc ataaataaca cctataaccg gttgcagctg gtagtttaga gagctgcagc 5040tgccgtcgtc ccggaggagg ggggccacct cgttgagcat gtccctgacg cgcatgttct 5100ccccgaccag atccgccaga aggcgctcgc cgcccaggga cagcagctct tgcaaggaag 5160caaagttttt cagcggcttg aggccgtccg ccgtgggcat gtttttcagg gtctggctca 5220gcagctccag gcggtcccag agctcggtga cgtgctctac ggcatctcta tccagcatat 5280ctcctcgttt cgcgggttgg ggcgactttc gctgtagggc accaagcggt ggtcgtccag 5340cggggccaga gtcatgtcct tccatgggcg cagggtcctc gtcagggtgg tctgggtcac 5400ggtgaagggg tgcgctccgg gctgagcgct tgccaaggtg cgcttgaggc tggttctgct 5460ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt 5520gtcatagtcc agcccctccg cggcgtgtcc cttggcgcgc agcttgccct tggaggtggc 5580gccgcacgag gggcagagca ggctcttgag cgcgtagagc ttgggggcga ggaagaccga 5640ttcgggggag taggcgtccg cgccgcagac cccgcacacg gtctcgcact ccaccagcca 5700ggtgagctcg gggcgcgccg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt 5760cttacctcgg gtctccatga ggtggtgtcc ccgctcggtg acgaagaggc tgtccgtgtc 5820tccgtagacc gacttgaggg gtcttttctc caggggggtc cctcggtctt cctcgtagag 5880gaactcggac cactctgaga cgaaggcccg cgtccaggcc aggacgaagg aggctatgtg 5940ggaggggtag cggtcgttgt ccactagggg gtccaccttc tccaaggtgt gaagacacat 6000gtcgccttcc tcggcgtcca ggaaggtgat tggcttgtag gtgtaggcca cgtgaccggg 6060ggttcctgac gggggggtat aaaagggggt gggggcgcgc tcgtcgtcac tctcttccgc 6120atcgctgtct gcgagggcca gctgctgggg tgagtattcc ctctcgaagg cgggcatgac 6180ctccgcgctg aggttgtcag tttccaaaaa cgaggaggat ttgatgttca cctgtcccga 6240ggtgatacct ttgagggtac ccgcgtccat ctggtcagaa aacacgatct ttttattgtc 6300cagcttggtg gcgaacgacc cgtagagggc gttggagagc agcttggcga tggagcgcag 6360ggtctggttc ttgtccctgt cggcgcgctc cttggccgcg atgttgagct gcacgtactc 6420gcgcgcgacg cagcgccact cggggaagac ggtggtgcgc tcgtcgggca ccaggcgcac 6480gcgccagccg cggttgtgca gggtgaccag gtccacgctg gtggcgacct cgccgcgcag 6540gcgctcgttg gtccagcaga gacggccgcc cttgcgcgag cagaaggggg gcagggggtc 6600gagctgggtc tcgtccgggg ggtccgcgtc cacggtgaaa accccggggc gcaggcgcgc 6660gtcgaagtag tctatcttgc aaccttgcat gtccagcgcc tgctgccagt cgcgggcggc 6720gagcgcgcgc tcgtaggggt tgagcggcgg gccccagggc atggggtggg tgagtgcgga 6780ggcgtacatg ccgcagatgt catagacgta gaggggctcc cgcaggaccc cgatgtaggt 6840ggggtagcag cggccgccgc ggatgctggc gcgcacgtag tcatacagct cgtgcgaggg 6900ggcgaggagg tcggggccca ggttggtgcg ggcggggcgc tccgcgcgga agacgatctg 6960cctgaagatg gcatgcgagt tggaagagat ggtggggcgc tggaagacgt tgaagctggc 7020gtcctgcagg ccgacggcgt cgcgcacgaa ggaggcgtag gagtcgcgca gcttgtgtac 7080cagctcggcg gtgacctgca cgtcgagcgc gcagtagtcg agggtctcgc ggatgatgtc 7140atatttagcc tgccccttct ttttccacag ctcgcggttg aggacaaact cttcgcggtc 7200tttccagtac tcttggatcg ggaaaccgtc cggttccgaa cggtaagagc ctagcatgta 7260gaactggttg acggcctggt aggcgcagca gcccttctcc acggggaggg cgtaggcctg 7320cgcggccttg cggagcgagg tgtgggtcag ggcgaaggtg tccctgacca tgactttgag 7380gtactggtgc ttgaagtcgg agtcgtcgca gccgccccgc tcccagagcg agaagtcggt 7440gcgcttcttg gagcgggggt tgggcagagc gaaggtgaca tcgttgaaga ggattttgcc 7500cgcgcggggc atgaagttgc gggtgatgcg gaagggcccc ggcacttcag agcggttgtt 7560gatgacctgg gcggcgagca cgatctcgtc gaagccgttg atgttgtggc ccacgatgta 7620gagttccagg aagcggggcc ggccctttac ggtgggcagc ttctttagct cttcgtaggt 7680gagctcctcg ggcgaggcga ggccgtgctc ggccagggcc cagtccgcga ggtgcgggtt 7740gtctctgagg aaggacttcc agaggtcgcg ggccaggagg gtctgcaggc ggtctctgaa 7800ggtcctgaac tggcggccca cggccatttt ttcgggggtg atgcagtaga aggtgagggg 7860gtcttgctgc cagcggtccc agtcgagctg cagggcgagg tcgcgcgcgg cggtgaccag 7920gcgctcgtcg cccccgaatt tcatgaccag catgaagggc acgagctgct ttccgaaggc 7980ccccatccaa gtgtaggtct ctacatcgta ggtgacaaag aggcgctccg tgcgaggatg 8040cgagccgatc gggaagaact ggatctcccg ccaccagttg gaggagtggc tgttgatgtg 8100gtggaagtag aagtcccgtc gccgggccga acactcgtgc tggcttttgt aaaagcgagc 8160gcagtactgg cagcgctgca cgggctgtac ctcatgcacg agatgcacct ttcgcccgcg 8220cacgaggaag ccgaggggaa atctgagccc cccgcctggc tcgcggcatg gctggttctc 8280ttctactttg gatgcgtgtc cgtctccgtc tggctcctcg aggggtgtta cggtggagcg 8340gaccaccacg ccgcgcgagc cgcaggtcca gatatcggcg cgcggcggtc ggagtttgat 8400gacgacatcg cgcagctggg agctgtccat ggtctggagc tcccgcggcg gcggcaggtc 8460agccgggagt tcttgcaggt tcacctcgca gagtcgggcc agggcgcggg gcaggtctag 8520gtggtacctg atctctaggg gcgtgttggt ggcggcgtcg atggcttgca ggagcccgca 8580gccccggggg gcgacgacgg tgccccgcgg ggtggtggtg gtggtggcgg tgcagctcag 8640aagcggtgcc gcgggcgggc ccccggaggt agggggggct ccggtcccgc gggcaggggc 8700ggcagcggca cgtcggcgtg gagcgcgggc aggagttggt gctgtgcccg gaggttgctg 8760gcgaaggcga cgacgcggcg gttgatctcc tggatctggc gcctctgcgt gaagacgacg 8820ggcccggtga gcttgaacct gaaagagagt tcgacagaat caatctcggt gtcattgacc 8880gcggcctggc gcaggatctc ctgcacgtct cccgagttgt cttggtaggc gatctcggcc 8940atgaactgct cgatctcttc ctcctggagg tctccgcgtc cggcgcgttc cacggtggcc 9000gccaggtcgt tggagatgcg ccccatgagc tgcgagaagg cgttgagtcc gccctcgttc 9060cagactcggc tgtagaccac gcccccctgg tcatcgcggg cgcgcatgac cacctgcgcg 9120aggttgagct ccacgtgccg cgcgaagacg gcgtagttgc gcagacgctg gaagaggtag 9180ttgagggtgg tggcggtgtg ctcggccacg aagaagttca tgacccagcg gcgcaacgtg 9240gattcgttga tgtcccccaa ggcctccagc cgttccatgg cctcgtagaa gtccacggcg 9300aagttgaaaa actgggagtt gcgcgccgac acggtcaact cctcctccag aagacggatg 9360agctcggcga cggtgtcgcg cacctcgcgc tcgaaggcta tggggatctc ttcctccgct 9420agcatcacca cctcctcctc ttcctcctct tctggcactt ccatgatggc ttcctcctct 9480tcggggggtg gcggcggcgg cggtggggga gggggcgctc tgcgccggcg gcggcgcacc 9540gggaggcggt ccacgaagcg cgcgatcatc tccccgcggc ggcggcgcat ggtctcggtg 9600acggcgcggc cgttctcccg ggggcgcagt tggaagacgc cgccggacat ctggtgctgg 9660ggcgggtggc cgtgaggcag cgagacggcg ctgacgatgc atctcaacaa ttgctgcgta 9720ggtacgccgc cgagggacct gagggagtcc atatccaccg gatccgaaaa cctttcgagg 9780aaggcgtcta accagtcgca gtcgcaaggt aggctgagca ccgtggcggg cggcgggggg 9840tggggggagt gtctggcgga ggtgctgctg atgatgtaat tgaagtaggc ggacttgaca 9900cggcggatgg tcgacaggag caccatgtcc ttgggtccgg cctgctggat gcggaggcgg 9960tcggctatgc cccaggcttc gttctggcat cggcgcaggt ccttgtagta gtcttgcatg 10020agcctttcca ccggcacctc ttctccttcc tcttctgctt cttccatgtc tgcttcggcc 10080ctggggcggc gccgcgcccc cctgcccccc atgcgcgtga ccccgaaccc cctgagcggt 10140tggagcaggg ccaggtcggc gacgacgcgc tcggccagga tggcctgctg cacctgcgtg 10200agggtggttt ggaagtcatc caagtccacg aagcggtggt aggcgcccgt gttgatggtg 10260taggtgcagt tggccatgac ggaccagttg acggtctggt ggcccggttg cgacatctcg 10320gtgtacctga gtcgcgagta ggcgcgggag tcgaagacgt agtcgttgca agtccgcacc 10380aggtactggt agcccaccag gaagtgcggc ggcggctggc ggtagagggg ccagcgcagg 10440gtggcggggg ctccgggggc caggtcttcc agcatgaggc ggtggtaggc gtagatgtac 10500ctggacatcc aggtgatacc cgcggcggtg gtggaggcgc gcgggaagtc gcgcacccgg 10560ttccagatgt tgcgcagggg cagaaagtgc tccatggtag gcgtgctctg tccagtcaga 10620cgcgcgcagt cgttgatact ctagaccagg gaaaacgaaa gccggtcagc gggcactctt 10680ccgtggtctg gtgaatagat cgcaagggta tcatggcgga gggcctcggt tcgagccccg 10740ggtccgggcc ggacggtccg ccatgatcca cgcggttacc gcccgcgtgt cgaacccagg 10800tgtgcgacgt cagacaacgg tggagtgttc cttttggcgt ttttctggcc gggcgccggc 10860gccgcgtaag agactaagcc gcgaaagcga aagcagtaag tggctcgctc cccgtagccg 10920gagggatcct tgctaagggt tgcgttgcgg cgaaccccgg ttcgaatccc gtactcgggc 10980cggccggacc cgcggctaag gtgttggatt ggcctccccc tcgtataaag accccgcttg 11040cggattgact ccggacacgg ggacgagccc cttttatttt tgctttcccc agatgcatcc 11100ggtgctgcgg cagatgcgcc ccccgcccca gcagcagcaa caacaccagc aagagcggca 11160gcaacagcag cgggagtcat gcagggcccc ctcacccacc ctcggcgggc cggccacctc 11220ggcgtccgcg gccgtgtctg gcgcctgcgg cggcggcggg gggccggctg acgaccccga 11280ggagcccccg cggcgcaggg ccagacacta cctggacctg gaggagggcg agggcctggc 11340gcggctgggg gcgccgtctc ccgagcgcca cccgcgggtg cagctgaagc gcgactcgcg 11400cgaggcgtac gtgcctcggc agaacctgtt cagggaccgc gcgggcgagg agcccgagga 11460gatgcgggac aggaggttca gcgcagggcg ggagctgcgg caggggctga accgcgagcg 11520gctgctgcgc gaggaggact ttgagcccga cgcgcggacg gggatcagcc ccgcgcgcgc 11580gcacgtggcg gccgccgacc tggtgacggc gtacgagcag acggtgaacc aggagatcaa 11640cttccaaaag agtttcaaca accacgtgcg cacgctggtg gcgcgcgagg aggtgaccat 11700cgggctgatg cacctgtggg actttgtaag cgcgctggtg cagaacccca acagcaagcc 11760tctgacggcg cagctgttcc tgatagtgca gcacagcagg gacaacgagg cgtttaggga 11820cgcgctgctg aacatcaccg agcccgaggg tcggtggctg ctggacctga ttaacatcct 11880gcagagcata gtggtgcagg agcgcagcct gagcctggcc gacaaggtgg cggccatcaa 11940ctactcgatg ctgagcctgg gcaagtttta cgcgcgcaag atctaccaga cgccgtacgt 12000gcccatagac aaggaggtga agatcgacgg tttttacatg cgcatggcgc tgaaggtgct 12060caccctgagc gacgacctgg gcgtgtaccg caacgagcgc atccacaagg ccgtgagcgt 12120gagccggcgg cgcgagctga gcgaccgcga gctgatgcac agcctgcagc gggcgctggc 12180gggcgccggc agcggcgaca gggaggcgga gtcctacttc gatgcggggg cggacctgcg 12240ctgggcgccc agccggcggg ccctggaggc cgcgggggtc cgcgaggact atgacgagga 12300cggcgaggag gatgaggagt acgagctaga ggagggcgag tacctggact aaaccgcggg 12360tggtgtttcc ggtagatgca agacccgaac gtggtggacc cggcgctgcg ggcggctctg 12420cagagccagc cgtccggcct taactcctca gacgactggc gacaggtcat ggaccgcatc 12480atgtcgctga cggcgcgtaa cccggacgcg ttccggcagc agccgcaggc caacaggctc 12540tccgccatcc tggaggcggt ggtgcctgcg cgctcgaacc ccacgcacga gaaggtgctg 12600gccatagtga acgcgctggc cgagaacagg gccatccgcc cggacgaggc cgggctggtg 12660tacgacgcgc tgctgcagcg cgtggcccgc tacaacagcg gcaacgtgca gaccaacctg 12720gaccggctgg tgggggacgt gcgcgaggcg gtggcgcagc gcgagcgcgc ggatcggcag 12780ggcaacctgg gctccatggt ggcgctgaat gccttcctga gcacgcagcc ggccaacgtg 12840ccgcgggggc aggaagacta caccaacttt gtgagcgcgc tgcggctgat ggtgaccgag 12900accccccaga gcgaggtgta ccagtcgggc ccggactact tcttccagac cagcagacag 12960ggcctgcaga cggtgaacct gagccaggct ttcaagaacc tgcgggggct gtggggcgtg 13020aaggcgccca ccggcgaccg ggcgacggtg tccagcctgc tgacgcccaa ctcgcgcctg 13080ctgctgctgc tgatcgcgcc gttcacggac agcggcagcg tgtcccggga cacctacctg 13140gggcacctgc tgaccctgta ccgcgaggcc atcgggcagg cgcaggtgga cgagcacacc 13200ttccaggaga tcaccagcgt gagccgcgcg ctggggcagg aggacacgag cagcctggag 13260gcgactctga actacctgct gaccaaccgg cggcagaaga ttccctcgct gcacagcctg 13320acctccgagg aggagcgcat cttgcgctac gtgcagcaga gcgtgagcct gaacctgatg 13380cgcgacgggg tgacgcccag cgtggcgctg gacatgaccg cgcgcaacat ggaaccgggc 13440atgtacgccg cgcaccggcc ttacatcaac cgcctgatgg actacctgca tcgcgcggcg 13500gccgtgaacc ccgagtactt taccaacgcc atcctgaacc cgcactggct cccgccgccc 13560gggttctaca gcgggggctt cgaggtcccg gagaccaacg atggcttcct gtgggacgac 13620atggacgaca gcgtgttctc cccgcggccg caggcgctgg cggaagcgtc cctgctgcgt 13680cccaagaagg aggaggagga ggaggcgagt cgccgccgcg gcagcagcgg cgtggcttct 13740ctgtccgagc tgggggcggc agccgccgcg cgccccgggt ccctgggcgg cagccccttt 13800ccgagcctgg tggggtctct gcacagcgag cgcaccaccc gccctcggct gctgggcgag 13860gacgagtacc tgaataactc cctgctgcag ccggtgcggg agaaaaacct gcctcccgcc 13920ttccccaaca acgggataga gagcctggtg gacaagatga gcagatggaa gacctatgcg 13980caggagcaca gggacgcgcc tgcgctccgg ccgcccacgc ggcgccagcg ccacgaccgg 14040cagcgggggc tggtgtggga tgacgaggac tccgcggacg atagcagcgt gctggacctg 14100ggagggagcg gcaacccgtt cgcgcacctg cgcccccgcc tggggaggat gttttaaaaa 14160aaaaaaaaaa aagcaagaag catgatgcaa aaattaaata aaactcacca aggccatggc 14220gaccgagcgt tggtttcttg tgttcccttc agtatgcggc gcgcggcgat gtaccaggag 14280ggacctcctc cctcttacga gagcgtggtg ggcgcggcgg cggcggcgcc ctcttctccc 14340tttgcgtcgc agctgctgga gccgccgtac gtgcctccgc gctacctgcg gcctacgggg 14400gggagaaaca gcatccgtta ctcggagctg gcgcccctgt tcgacaccac ccgggtgtac 14460ctggtggaca acaagtcggc ggacgtggcc tccctgaact accagaacga ccacagcaat 14520tttttgacca cggtcatcca gaacaatgac tacagcccga gcgaggccag cacccagacc 14580atcaatctgg atgaccggtc gcactggggc ggcgacctga aaaccatcct gcacaccaac 14640atgcccaacg tgaacgagtt catgttcacc aataagttca aggcgcgggt gatggtgtcg 14700cgctcgcaca ccaaggaaga ccgggtggag ctgaagtacg agtgggtgga gttcgagctg 14760ccagagggca actactccga gaccatgacc attgacctga tgaacaacgc gatcgtggag 14820cactatctga aagtgggcag gcagaacggg gtcctggaga gcgacatcgg ggtcaagttc 14880gacaccagga acttccgcct ggggctggac cccgtgaccg ggctggttat gcccggggtg 14940tacaccaacg aggccttcca tcccgacatc atcctgctgc ccggctgcgg ggtggacttc 15000acttacagcc gcctgagcaa cctcctgggc atccgcaagc ggcagccctt ccaggagggc 15060ttcaggatca cctacgagga cctggagggg ggcaacatcc ccgcgctcct cgatgtggag 15120gcctaccagg atagcttgaa ggaaaatgag gcgggacagg aggataccgc ccccgccgcc 15180tccgccgccg ccgagcaggg cgaggatgct gctgacaccg cggccgcgga cggggcagag 15240gccgaccccg ctatggtggt ggaggctccc gagcaggagg aggacatgaa tgacagtgcg 15300gtgcgcggag acaccttcgt cacccggggg gaggaaaagc aagcggaggc cgaggccgcg 15360gccgaggaaa agcaactggc ggcagcagcg gcggcggcgg cgttggccgc ggcggaggct 15420gagtctgagg ggaccaagcc cgccaaggag cccgtgatta agcccctgac cgaagatagc 15480aagaagcgca gttacaacct gctcaaggac agcaccaaca ccgcgtaccg cagctggtac 15540ctggcctaca actacggcga cccgtcgacg ggggtgcgct cctggaccct gctgtgcacg 15600ccggacgtga cctgcggctc ggagcaggtg tactggtcgc tgcccgacat gatgcaagac 15660cccgtgacct tccgctccac gcggcaggtc agcaacttcc cggtggtggg cgccgagctg 15720ctgcccgtgc actccaagag cttctacaac gaccaggccg tctactccca gctcatccgc 15780cagttcacct ctctgaccca cgtgttcaat cgctttcctg agaaccagat tctggcgcgc 15840ccgcccgccc ccaccatcac caccgtcagt gaaaacgttc ctgctctcac agatcacggg 15900acgctaccgc tgcgcaacag catcggagga gtccagcgag tgaccgttac tgacgccaga 15960cgccgcacct gcccctacgt ttacaaggcc ttgggcatag tctcgccgcg cgtcctttcc 16020agccgcactt tttgagcaac accaccatca tgtccatcct gatctcaccc agcaataact 16080ccggctgggg actgctgcgc gcgcccagca agatgttcgg aggggcgagg aagcgttccg 16140agcagcaccc cgtgcgcgtg cgcgggcact tccgcgcccc ctggggagcg cacaaacgcg 16200gccgcgcggg gcgcaccacc gtggacgacg ccatcgactc ggtggtggag caggcgcgca 16260actacaggcc cgcggtctct accgtggacg cggccatcca gaccgtggtg cggggcgcgc 16320ggcggtacgc caagctgaag agccgccgga agcgcgtggc ccgccgccac cgccgccgac 16380ccggggccgc cgccaaacgc gccgccgcgg ccctgcttcg ccgggccaag cgcacgggcc 16440gccgcgccgc catgagggcc gcgcgccgct tggccgccgg catcaccgcc gccaccatgg 16500ccccccgtac ccgaagacgc gcggccgccg ccgccgccgc cgccatcagt gacatggcca 16560gcaggcgccg gggcaacgtg tactgggtgc gcgactcggt gaccggcacg cgcgtgcccg 16620tgcgcttccg ccccccgcgg acttgagatg atgtgaaaaa acaacactga gtctcctgct 16680gttgtgtgta tcccagcggc ggcggcgcgc gcagcgtcat gtccaagcgc aaaatcaaag 16740aagagatgct ccaggtcgtc gcgccggaga tctatgggcc cccgaagaag gaagagcagg 16800attcgaagcc ccgcaagata aagcgggtca aaaagaaaaa gaaagatgat gacgatgccg 16860atggggaggt ggagttcctg cgcgccacgg cgcccaggcg cccggtgcag tggaagggcc 16920ggcgcgtaaa gcgcgtcctg cgccccggca ccgcggtggt cttcacgccc ggcgagcgct 16980ccacccggac tttcaagcgc gtctatgacg aggtgtacgg cgacgaagac ctgctggagc 17040aggccaacga gcgcttcgga gagtttgctt acgggaagcg tcagcgggcg ctggggaagg 17100aggacctgct ggcgctgccg ctggaccagg gcaaccccac ccccagtctg aagcccgtga 17160ccctgcagca ggtgctgccg agcagcgcac cctccgaggc gaagcggggt ctgaagcgcg 17220agggcggcga cctggcgccc accgtgcagc tcatggtgcc caagcggcag aggctggagg 17280atgtgctgga gaaaatgaaa gtagaccccg gtctgcagcc ggacatcagg gtccgcccca 17340tcaagcaggt ggcgccgggc ctcggcgtgc agaccgtgga cgtggtcatc cccaccggca 17400actcccccgc cgccgccacc actaccgctg cctccacgga catggagaca cagaccgatc 17460ccgccgcagc cgcagccgca gccgccgccg cgacctcctc ggcggaggtg cagacggacc 17520cctggctgcc gccggcgatg tcagctcccc gcgcgcgtcg cgggcgcagg aagtacggcg 17580ccgccaacgc gctcctgccc gagtacgcct tgcatccttc catcgcgccc acccccggct 17640accgaggcta tacctaccgc ccgcgaagag ccaagggttc cacccgccgt ccccgccgac 17700gcgccgccgc caccacccgc cgccgccgcc gcagacgcca gcccgcactg gctccagtct 17760ccgtgaggaa agtggcgcgc gacggacaca ccctggtgct gcccagggcg cgctaccacc 17820ccagcatcgt ttaaaagcct gttgtggttc ttgcagatat ggccctcact tgccgcctcc 17880gtttcccggt gccgggatac cgaggaggaa gatcgcgccg caggaggggt ctggccggcc 17940gcggcctgag cggaggcagc cgccgcgcgc accggcggcg acgcgccacc agccgacgca 18000tgcgcggcgg ggtgctgccc ctgttaatcc ccctgatcgc cgcggcgatc ggcgccgtgc 18060ccgggatcgc ctccgtggcc ttgcaagcgt cccagaggca ttgacagact tgcaaacttg 18120caaatatgga aaaaaaaacc ccaataaaaa agtctagact ctcacgctcg cttggtcctg 18180tgactatttt gtagaatgga agacatcaac tttgcgtcgc tggccccgcg tcacggctcg 18240cgcccgttcc tgggacactg gaacgatatc ggcaccagca acatgagcgg tggcgccttc 18300agttggggct ctctgtggag cggcattaaa agtatcgggt ctgccgttaa aaattacggc 18360tcccgggcct ggaacagcag cacgggccag atgttgagag acaagttgaa agagcagaac 18420ttccagcaga aggtggtgga gggcctggcc tccggcatca acggggtggt ggacctggcc 18480aaccaggccg tgcagaataa gatcaacagc agactggacc cccggccgcc ggtggaggag 18540gtgccgccgg cgctggagac ggtgtccccc gatgggcgtg gcgagaagcg cccgcggccc 18600gatagggaag agaccactct ggtcacgcag accgatgagc cgcccccgta tgaggaggcc 18660ctgaagcaag gtctgcccac cacgcggccc atcgcgccca tggccaccgg ggtggtgggc 18720cgccacaccc ccgccacgct ggacttgcct ccgcccgccg atgtgccgca gcagcagaag 18780gcggcacagc cgggcccgcc cgcgaccgcc tcccgttcct ccgccggtcc tctgcgccgc 18840gcggccagcg gcccccgcgg gggggtcgcg aggcacggca actggcagag cacgctgaac 18900agcatcgtgg gtctgggggt gcggtccgtg aagcgccgcc gatgctactg aatagcttag 18960ctaacgtgtt gtatgtgtgt atgcgcccta tgtcgccgcc agaggagctg ctgagtcgcc 19020gccgttcgcg cgcccaccac caccgccact ccgcccctca agatggcgac cccatcgatg 19080atgccgcagt ggtcgtacat gcacatctcg ggccaggacg cctcggagta cctgagcccc 19140gggctggtgc agttcgcccg cgccaccgag agctacttca gcctgagtaa caagtttagg 19200aaccccacgg tggcgcccac gcacgatgtg accaccgacc ggtctcagcg cctgacgctg 19260cggttcattc ccgtggaccg cgaggacacc gcgtactcgt acaaggcgcg gttcaccctg 19320gccgtgggcg acaaccgcgt gctggacatg gcctccacct actttgacat ccgcggggtg 19380ctggaccggg gtcccacttt caagccctac

tctggcaccg cctacaactc cctggccccc 19440aagggcgctc ccaactcctg cgagtgggag caagaggaaa ctcaggcagt tgaagaagca 19500gcagaagagg aagaagaaga tgctgacggt caagctgagg aagagcaagc agctaccaaa 19560aagactcatg tatatgctca ggctcccctt tctggcgaaa aaattagtaa agatggtctg 19620caaataggaa cggacgctac agctacagaa caaaaaccta tttatgcaga ccctacattc 19680cagcccgaac cccaaatcgg ggagtcccag tggaatgagg cagatgctac agtcgccggc 19740ggtagagtgc taaagaaatc tactcccatg aaaccatgct atggttccta tgcaagaccc 19800acaaatgcta atggaggtca gggtgtacta acggcaaatg cccagggaca gctagaatct 19860caggttgaaa tgcaattctt ttcaacttct gaaaacgccc gtaacgaggc taacaacatt 19920cagcccaaat tggtgctgta tagtgaggat gtgcacatgg agaccccgga tacgcacctt 19980tcttacaagc ccgcaaaaag cgatgacaat tcaaaaatca tgctgggtca gcagtccatg 20040cccaacagac ctaattacat cggcttcaga gacaacttta tcggcctcat gtattacaat 20100agcactggca acatgggagt gcttgcaggt caggcctctc agttgaatgc agtggtggac 20160ttgcaagaca gaaacacaga actgtcctac cagctcttgc ttgattccat gggtgacaga 20220accagatact tttccatgtg gaatcaggca gtggacagtt atgacccaga tgttagaatt 20280attgaaaatc atggaactga agacgagctc cccaactatt gtttccctct gggtggcata 20340ggggtaactg acacttacca ggctgttaaa accaacaatg gcaataacgg gggccaggtg 20400acttggacaa aagatgaaac ttttgcagat cgcaatgaaa taggggtggg aaacaatttc 20460gctatggaga tcaacctcag tgccaacctg tggagaaact tcctgtactc caacgtggcg 20520ctgtacctac cagacaagct taagtacaac ccctccaatg tggacatctc tgacaacccc 20580aacacctacg attacatgaa caagcgagtg gtggccccgg ggctggtgga ctgctacatc 20640aacctgggcg cgcgctggtc gctggactac atggacaacg tcaacccctt caaccaccac 20700cgcaatgcgg gcctgcgcta ccgctccatg ctcctgggca acgggcgcta cgtgcccttc 20760cacatccagg tgccccagaa gttctttgcc atcaagaacc tcctcctcct gccgggctcc 20820tacacctacg agtggaactt caggaaggat gtcaacatgg tcctccagag ctctctgggt 20880aacgatctca gggtggacgg ggccagcatc aagttcgaga gcatctgcct ctacgccacc 20940ttcttcccca tggcccacaa cacggcctcc acgctcgagg ccatgctcag gaacgacacc 21000aacgaccagt ccttcaatga ctacctctcc gccgccaaca tgctctaccc catacccgcc 21060aacgccacca acgtccccat ctccatcccc tcgcgcaact gggcggcctt ccgcggctgg 21120gccttcaccc gcctcaagac caaggagacc ccctccctgg gctcgggatt cgacccctac 21180tacacctact cgggctccat tccctacctg gacggcacct tctacctcaa ccacactttc 21240aagaaggtct cggtcacctt cgactcctcg gtcagctggc cgggcaacga ccgtctgctc 21300acccccaacg agttcgagat caagcgctcg gtcgacgggg agggctacaa cgtggcccag 21360tgcaacatga ccaaggactg gttcctggtc cagatgctgg ccaactacaa catcggctac 21420cagggcttct acatcccaga gagctacaag gacaggatgt actccttctt caggaacttc 21480cagcccatga gccggcaggt ggtggaccag accaagtaca aggactacca ggaggtgggc 21540atcatccacc agcacaacaa ctcgggcttc gtgggctacc tcgcccccac catgcgcgag 21600ggacaggcct accccgccaa cttcccctat ccgctcatag gcaagaccgc ggtcgacagc 21660atcacccaga aaaagttcct ctgcgaccgc accctctggc gcatcccctt ctccagcaac 21720ttcatgtcca tgggtgcgct ctcggacctg ggccagaact tgctctacgc caactccgcc 21780cacgccctcg acatgacctt cgaggtcgac cccatggacg agcccaccct tctctatgtt 21840ctgttcgaag tctttgacgt ggtccgggtc caccagccgc accgcggcgt catcgagacc 21900gtgtacctgc gtacgccctt ctcggccggc aacgccacca cctaaagaag caagccgcag 21960tcatcgccgc ctgcatgccg tcgggttcca ccgagcaaga gctcagggcc atcgtcagag 22020acctgggatg cgggccctat tttttgggca ccttcgacaa gcgcttccct ggctttgtct 22080ccccacacaa gctggcctgc gccatcgtca acacggccgg ccgcgagacc gggggcgtgc 22140actggctggc cttcgcctgg aacccgcgct ccaaaacatg cttcctcttt gaccccttcg 22200gcttttcgga ccagcggctc aagcaaatct acgagttcga gtacgagggc ttgctgcgtc 22260gcagcgccat cgcctcctcg cccgaccgct gcgtcaccct cgaaaagtcc acccagaccg 22320tgcaggggcc cgactcggcc gcctgcggtc tcttctgctg catgtttctg cacgcctttg 22380tgcactggcc tcagagtccc atggaccgca accccaccat gaacttgctg acgggggtgc 22440ccaactccat gctccagagc ccccaggtcg agcccaccct gcgccgcaac caggagcagc 22500tctacagctt cctggagcgc cactcgcctt acttccgccg ccacagcgca cagatcagga 22560gggccacctc cttctgccac ttgcaagaga tgcaagaagg gtaataacga tgtacacact 22620ttttttctca ataaatggca tctttttatt tatacaagct ctctggggta ttcatttccc 22680accaccaccc gccgttgtcg ccatctggct ctatttagaa atcgaaaggg ttctgccggg 22740agtcgccgtg cgccacgggc agggacacgt tgcgatactg gtagcgggtg ccccacttga 22800actcgggcac caccaggcga ggcagctcgg ggaagttttc gctccacagg ctgcgggtca 22860gcaccagcgc gttcatcagg tcgggcgccg agatcttgaa gtcgcagttg gggccgccgc 22920cctgcgcgcg cgagttgcgg tacaccgggt tgcagcactg gaacaccaac agcgccgggt 22980gcttcacgct ggccagcacg ctgcggtcgg agatcagctc ggcgtccagg tcctccgcgt 23040tgctcagcgc gaacggggtc atcttgggca cttgccgccc caggaagggc gcgtgccccg 23100gtttcgagtt gcagtcgcag cgcagcggga tcagcaggtg cccgtgcccg gactcggcgt 23160tggggtacag cgcgcgcatg aaggcctgca tctggcggaa ggccatctgg gccttggcgc 23220cctccgagaa gaacatgccg caggacttgc ccgagaactg gtttgcgggg cagctggcgt 23280cgtgcaggca gcagcgcgcg tcggtgttgg cgatctgcac cacgttgcgc ccccaccggt 23340tcttcacgat cttggccttg gacgattgct ccttcagcgc gcgctgcccg ttctcgctgg 23400tcacatccat ctcgatcaca tgttccttgt tcaccatgct gctgccgtgc agacacttca 23460gctcgccctc cgtctcggtg cagcggtgct gccacagcgc gcagcccgtg ggctcgaaag 23520acttgtaggt cacctccgcg aaggactgca ggtacccctg caaaaagcgg cccatcatgg 23580tcacgaaggt cttgttgctg ctgaaggtca gctgcagccc gcggtgctcc tcgttcagcc 23640aggtcttgca cacggccgcc agcgcctcca cctggtcggg cagcatcttg aagttcacct 23700tcagctcatt ctccacgtgg tacttgtcca tcagcgtgcg cgccgcctcc atgcccttct 23760cccaggccga caccagcggc aggctcacgg ggttcttcac catcaccgtg gccgccgcct 23820ccgccgcgct ttcgctttcc gccccgctgt tctcttcctc ttcctcctct tcctcgccgc 23880cgcccactcg cagcccccgc accacggggt cgtcttcctg caggcgctgc accttgcgct 23940tgccgttgcg cccctgcttg atgcgcacgg gcgggttgct gaagcccacc atcaccagcg 24000cggcctcttc ttgctcgtcc tcgctgtcca gaatgacctc cggggagggg gggttggtca 24060tcctcagtac cgaggcacgc ttctttttct tcctgggggc gttcgccagc tccgcggctg 24120cggccgctgc cgaggtcgaa ggccgagggc tgggcgtgcg cggcaccagc gcgtcctgcg 24180agccgtcctc gtcctcctcg gactcgagac ggaggcgggc ccgcttcttc gggggcgcgc 24240ggggcggcgg aggcggcggc ggcgacggag acggggacga gacatcgtcc agggtgggtg 24300gacggcgggc cgcgccgcgt ccgcgctcgg gggtggtctc gcgctggtcc tcttcccgac 24360tggccatctc ccactgctcc ttctcctata ggcagaaaga gatcatggag tctctcatgc 24420gagtcgagaa ggaggaggac agcctaaccg ccccctctga gccctccacc accgccgcca 24480ccaccgccaa tgccgccgcg gacgacgcgc ccaccgagac caccgccagt accaccctcc 24540ccagcgacgc acccccgctc gagaatgaag tgctgatcga gcaggacccg ggttttgtga 24600gcggagagga ggatgaggtg gatgagaagg agaaggagga ggtcgccgcc tcagtgccaa 24660aagaggataa aaagcaagac caggacgacg cagataagga tgagacagca gtcgggcggg 24720ggaacggaag ccatgatgct gatgacggct acctagacgt gggagacgac gtgctgctta 24780agcacctgca ccgccagtgc gtcatcgtct gcgacgcgct gcaggagcgc tgcgaagtgc 24840ccctggacgt ggcggaggtc agccgcgcct acgagcggca cctcttcgcg ccgcacgtgc 24900cccccaagcg ccgggagaac ggcacctgcg agcccaaccc gcgtctcaac ttctacccgg 24960tcttcgcggt acccgaggtg ctggccacct accacatctt tttccaaaac tgcaagatcc 25020ccctctcctg ccgcgccaac cgcacccgcg ccgacaaaac cctgaccctg cggcagggcg 25080cccacatacc tgatatcgcc tctctggagg aagtgcccaa gatcttcgag ggtctcggtc 25140gcgacgagaa acgggcggcg aacgctctgc acggagacag cgaaaacgag agtcactcgg 25200gggtgctggt ggagctcgag ggcgacaacg cgcgcctggc cgtactcaag cgcagcatag 25260aggtcaccca ctttgcctac ccggcgctca acctgccccc caaggtcatg agtgtggtca 25320tgggcgagct catcatgcgc cgcgcccagc ccctggccgc ggatgcaaac ttgcaagagt 25380cctccgagga aggcctgccc gcggtcagcg acgagcagct ggcgcgctgg ctggagaccc 25440gcgaccccgc gcagctggag gagcggcgca agctcatgat ggccgcggtg ctggtcaccg 25500tggagctcga gtgtctgcag cgcttcttcg cggaccccga gatgcagcgc aagctcgagg 25560agaccctgca ctacaccttc cgccagggct acgtgcgcca ggcctgcaag atctccaacg 25620tggagctctg caacctggtc tcctacctgg gcatcctgca cgagaaccgc ctcgggcaga 25680acgtcctgca ctccaccctc aaaggggagg cgcgccgcga ctacatccgc gactgcgcct 25740acctcttcct ctgctacacc tggcagacgg ccatgggggt ctggcagcag tgcctggagg 25800agcgcaacct caaggagctg gaaaagctcc tcaagcgcac cctcagggac ctctggacgg 25860gcttcaacga gcgctcggtg gccgccgcgc tggcggacat catctttccc gagcgcctgc 25920tcaagaccct gcagcagggc ctgcccgact tcaccagcca gagcatgctg cagaacttca 25980ggactttcat cctggagcgc tcgggcatcc tgccggccac ttgctgcgcg ctgcccagcg 26040acttcgtgcc catcaagtac agggagtgcc cgccgccgct ctggggccac tgctacctct 26100tccagctggc caactacctc gcctaccact cggacctcat ggaagacgtg agcggcgagg 26160gcctgctcga gtgccactgc cgctgcaacc tctgcacgcc ccaccgctct ctagtctgca 26220acccgcagct gctcagcgag agtcagatta tcggtacctt cgagctgcag ggtccctcgc 26280ctgacgagaa gtccgcggct ccagggctga aactcactcc ggggctgtgg acttccgcct 26340acctacgcaa atttgtacct gaggactacc acgcccacga gatcaggttc tacgaagacc 26400aatcccgccc gcccaaggcg gagctcaccg cctgcgtcat cacccagggg cacatcctgg 26460gccaattgca agccatcaac aaagcccgcc gagagttctt gctgaaaaag ggtcgggggg 26520tgtacctgga cccccagtcc ggcgaggagc taaacccgct acccccgccg ccgccccagc 26580agcgggacct tgcttcccag gatggcaccc agaaagaagc agcagccgcc gccgccgccg 26640cagccataca tgcttctgga ggaagaggag gaggactggg acagtcaggc agaggaggtt 26700tcggacgagg agcaggagga gatgatggaa gactgggagg aggacagcag cctagacgag 26760gaagcttcag aggccgaaga ggtggcagac gcaacaccat cgccctcggt cgcagccccc 26820tcgccggggc ccctgaaatc ctccgaaccc agcaccagcg ctataacctc cgctcctccg 26880gcgccggcgc cacccgcccg cagacccaac cgtagatggg acaccacagg aaccggggtc 26940ggtaagtcca agtgcccgcc gccgccaccg cagcagcagc agcagcagcg ccagggctac 27000cgctcgtggc gcgggcacaa gaacgccata gtcgcctgct tgcaagactg cgggggcaac 27060atctctttcg cccgccgctt cctgctattc caccacgggg tcgcctttcc ccgcaatgtc 27120ctgcattact accgtcatct ctacagcccc tactgcagcg gcgacccaga ggcggcagcg 27180gcagccacag cggcgaccac cacctaggaa gatatcctcc gcgggcaaga cagcggcagc 27240agcggccagg agacccgcgg cagcagcggc gggagcggtg ggcgcactgc gcctctcgcc 27300caacgaaccc ctctcgaccc gggagctcag acacaggatc ttccccactt tgtatgccat 27360cttccaacag agcagaggcc aggagcagga gctgaaaata aaaaacagat ctctgcgctc 27420cctcacccgc agctgtctgt atcacaaaag cgaagatcag cttcggcgca cgctggagga 27480cgcggaggca ctcttcagca aatactgcgc gctcactctt aaagactagc tccgcgccct 27540tctcgaattt aggcgggaga aaactacgtc atcgccggcc gccgcccagc ccgcccagcc 27600gagatgagca aagagattcc cacgccatac atgtggagct accagccgca gatgggactc 27660gcggcgggag cggcccagga ctactccacc cgcatgaact acatgagcgc gggaccccac 27720atgatctcac aggtcaacgg gatccgcgcc cagcgaaacc aaatactgct ggaacaggcg 27780gccatcaccg ccacgccccg ccataatctc aacccccgaa attggcccgc cgccctcgtg 27840taccaggaaa ccccctccgc caccaccgta ctacttccgc gtgacgccca ggccgaagtc 27900cagatgacta actcaggggc gcagctcgcg ggcggctttc gtcacggggc gcggccgctc 27960cgaccaggta taagacacct gatgatcaga ggccgaggta tccagctcaa cgacgagtcg 28020gtgagctctt cgctcggtct ccgtccggac ggaactttcc agctcgccgg atccggccgc 28080tcttcgttca cgccccgcca ggcgtacctg actctgcaga cctcgtcctc ggagccccgc 28140tccggcggca tcggaaccct ccagttcgtg gaggagttcg tgccctcggt ctacttcaac 28200cccttctcgg gacctcccgg acgctacccc gaccagttca ttccgaactt tgacgcggtg 28260aaggactcgg cggacggcta cgactgaatg tcaggtgtcg aggcagagca gcttcgcctg 28320agacacctcg agcactgccg ccgccacaag tgcttcgccc gcggttctgg tgagttctgc 28380tactttcagc tacccgagga gcataccgag gggccggcgc acggcgtccg cctgaccacc 28440cagggcgagg ttacctgttc cctcatccgg gagtttaccc tccgtcccct gctagtggag 28500cgggagcggg gtccctgtgt cctaactatc gcctgcaact gccctaaccc tggattacat 28560caagatcttt gctgtcatct ctgtgctgag tttaataaac gctgagatca gaatctactg 28620gggctcctgt cgccatcctg tgaacgccac cgtcttcacc caccccgacc aggcccaggc 28680gaacctcacc tgcggtctgc atcggagggc caagaagtac ctcacctggt acttcaacgg 28740cacccccttt gtggtttaca acagcttcga cggggacgga gtctccctga aagaccagct 28800ctccggtctc agctactcca tccacaagaa caccaccctc caactcttcc ctccctacct 28860gccgggaacc tacgagtgcg tcaccggccg ctgcacccac ctcacccgcc tgatcgtaaa 28920ccagagcttt ccgggaacag ataactccct cttccccaga acaggaggtg agctcaggaa 28980actccccggg gaccagggcg gagacgtacc ttcgaccctt gtggggttag gattttttat 29040taccgggttg ctggctcttt taatcaaagt ttccttgaga tttgttcttt ccttctacgt 29100gtatgaacac ctcaacctcc aataactcta ccctttcttc ggaatcaggt gacttctctg 29160aaatcgggct tggtgtgctg cttactctgt tgattttttt ccttatcata ctcagccttc 29220tgtgcctcag gctcgccgcc tgctgcgcac acatctatat ctactgctgg ttgctcaagt 29280gcaggggtcg ccacccaaga tgaacaggta catggtccta tcgatcctag gcctgctggc 29340cctggcggcc tgcagcgccg ccaaaaaaga gattaccttt gaggagcccg cttgcaatgt 29400aactttcaag cccgagggtg accaatgcac caccctcgtc aaatgcgtta ccaatcatga 29460gaggctgcgc atcgactaca aaaacaaaac tggccagttt gcggtctata gtgtgtttac 29520gcccggagac ccctctaact actctgtcac cgtcttccag ggcggacagt ctaagatatt 29580caattacact ttcccttttt atgagttatg cgatgcggtc atgtacatgt caaaacagta 29640caacctgtgg cctccctctc cccaggcgtg tgtggaaaat actgggtctt actgctgtat 29700ggctttcgca atcactacgc tcgctctaat ctgcacggtg ctatacataa aattcaggca 29760gaggcgaatc tttatcgatg aaaagaaaat gccttgatcg ctaacaccgg ctttctatct 29820gcagaatgaa tgcaatcacc tccctactaa tcaccaccac cctccttgcg attgcccatg 29880ggttgacacg aatcgaagtg ccagtggggt ccaatgtcac catggtgggc cccgccggca 29940attccaccct catgtgggaa aaatttgtcc gcaatcaatg ggttcatttc tgctctaacc 30000gaatcagtat caagcccaga gccatctgcg atgggcaaaa tctaactctg atcaatgtgc 30060aaatgatgga tgctgggtac tattacgggc agcggggaga aatcattaat tactggcgac 30120cccacaagga ctacatgctg catgtagtcg aggcacttcc cactaccacc cccactacca 30180cctctcccac caccaccacc actactacta ctactactac tactactact actaccacta 30240ccgctgcccg ccatacccgc aaaagcacca tgattagcac aaagccccct cgtgctcact 30300cccacgccgg cgggcccatc ggtgcgacct cagaaaccac cgagctttgc ttctgccaat 30360gcactaacgc cagcgctcat gaactgttcg acctggagaa tgaggatgtc cagcagagct 30420ccgcttgcct gacccaggag gctgtggagc ccgttgccct gaagcagatc ggtgattcaa 30480taattgactc ttcttctttt gccactcccg aataccctcc cgattctact ttccacatca 30540cgggtaccaa agaccctaac ctctctttct acctgatgct gctgctctgt atctctgtgg 30600tctcttccgc gctgatgtta ctggggatgt tctgctgcct gatctgccgc agaaagagaa 30660aagctcgctc tcagggccaa ccactgatgc ccttccccta ccccccggat tttgcagata 30720acaagatatg agctcgctgc tgacactaac cgctttacta gcctgcgctc taacccttgt 30780cgcttgcgac tcgagattcc acaatgtcac agctgtggca ggagaaaatg ttactttcaa 30840ctccacggcc gatacccagt ggtcgtggag tggctcaggt agctacttaa ctatctgcaa 30900tagctccact tcccccggca tatccccaac caagtaccaa tgcaatgcca gcctgttcac 30960cctcatcaac gcttccaccc tggacaatgg actctatgta ggctatgtac cctttggtgg 31020gcaaggaaag acccacgctt acaacctgga agttcgccag cccagaacca ctacccaagc 31080ttctcccacc accaccacca ccaccaccat caccagcagc agcagcagca gcagccacag 31140cagcagcagc agattattga ctttggtttt ggccagctca tctgccgcta cccaggccat 31200ctacagctct gtgcccgaaa ccactcagat ccaccgccca gaaacgacca ccgccaccac 31260cctacacacc tccagcgatc agatgccgac caacatcacc cccttggctc ttcaaatggg 31320acttacaagc cccactccaa aaccagtgga tgcggccgag gtctccgccc tcgtcaatga 31380ctgggcgggg ctgggaatgt ggtggttcgc cataggcatg atggcgctct gcctgcttct 31440gctctggctc atctgctgcc tccaccgcag gcgagccaga ccccccatct atagacccat 31500cattgtcctg aaccccgata atgatgggat ccatagattg gatggcctga aaaacctact 31560tttttctttt acagtatgat aaattgagac atgcctcgca ttttcttgta catgttcctt 31620ctcccacctt ttctggggtg ttctacgctg gccgctgtgt ctcacctgga ggtagactgc 31680ctctcaccct tcactgtcta cctgctttac ggattggtca ccctcactct catctgcagc 31740ctaatcacag taatcatcgc cttcatccag tgcattgatt acatctgtgt gcgcctcgca 31800tacttcagac accacccgca gtaccgagac aggaacattg cccaacttct aagactgctc 31860taatcatgca taagactgtg atctgccttc tgatcctctg catcctgccc accctcacct 31920cctgccagta caccacaaaa tctccgcgca aaagacatgc ctcctgccgc ttcacccaac 31980tgtggaatat acccaaatgc tacaacgaaa agagcgagct ctccgaagct tggctgtatg 32040gggtcatctg tgtcttagtt ttctgcagca ctgtctttgc cctcataatc tacccctact 32100ttgatttggg atggaacgcg atcgatgcca tgaattaccc cacctttccc gcacccgaga 32160taattccact gcgacaagtt gtacccgttg tcgttaatca acgcccccca tcccctacgc 32220ccactgaaat cagctacttt aacctaacag gcggagatga ctgacgccct agatctagaa 32280atggacggca tcagtaccga gcagcgtctc ctagagaggc gcaggcaggc ggctgagcaa 32340gagcgcctca atcaggagct ccgagatctc gttaacctgc accagtgcaa aagaggcatc 32400ttttgtctgg taaagcaggc caaagtcacc tacgagaaga ccggcaacag ccaccgcctc 32460agttacaaat tgcccaccca gcgccagaag ctggtgctca tggtgggtga gaatcccatc 32520accgtcaccc agcactcggt agagaccgag gggtgtctgc actccccctg tcggggtcca 32580gaagacctct gcaccctggt aaagaccctg tgcggtctca gagatttagt cccctttaac 32640taatcaaaca ctggaatcaa taaaaagaat cacttactta aaatcagaca gcaggtctct 32700gtccagttta ttcagcagca cctccttccc ctcctcccaa ctctggtact ccaaacgcct 32760tctggcggca aacttcctcc acaccctgaa gggaatgtca gattcttgct cctgtccctc 32820cgcacccact atcttcatgt tgttgcagat gaagcgcacc aaaacgtctg acgagagctt 32880caaccccgtg tacccctatg acacggaaag cggccctccc tccgtccctt tcctcacccc 32940tcccttcgtg tctcccgatg gattccaaga aagtcccccc ggggtcctgt ctctgaacct 33000ggccgagccc ctggtcactt cccacggcat gctcgccctg aaaatgggaa gtggcctctc 33060cctggacgac gctggcaacc tcacctctca agatatcacc accgctagcc ctcccctcaa 33120aaaaaccaag accaacctca gcctagaaac ctcatccccc ctaactgtga gcacctcagg 33180cgccctcacc gtagcagccg ccgctcccct ggcggtggcc ggcacctccc tcaccatgca 33240atcagaggcc cccctgacag tacaggatgc aaaactcacc ctggccacca aaggccccct 33300gaccgtgtct gaaggcaaac tggccttgca aacatcggcc ccgctgacgg ccgctgacag 33360cagcaccctc acagtcagtg ccacaccacc ccttagcaca agcaatggca gcttgggtat 33420tgacatgcaa gcccccattt acaccaccaa tggaaaacta ggacttaact ttggcgctcc 33480cctgcatgtg gtagacagcc taaatgcact gactgtagtt actggccaag gtcttacgat 33540aaacggaaca gccctacaaa ctagagtctc aggtgccctc aactatgaca catcaggaaa 33600cctagaattg agagctgcag ggggtatgcg agttgatgca aatggtcaac ttatccttga 33660tgtagcttac ccatttgatg cacaaaacaa tctcagcctt aggcttggac agggacccct 33720gtttgttaac tctgcccaca acttggatgt taactacaac agaggcctct acctgttcac 33780atctggaaat accaaaaagc tagaagttaa tatcaaaaca gccaagggtc tcatttatga 33840tgacactgct atagcaatca atgcgggtga tgggctacag tttgactcag gctcagatac 33900aaatccatta aaaactaaac ttggattagg actggattat gactccagca gagccataat 33960tgctaaactg ggaactggcc taagctttga caacacaggt gccatcacag taggcaacaa 34020aaatgatgac aagcttacct tgtggaccac accagaccca tcccctaact gtagaatcta 34080ttcagagaaa gatgctaaat tcacacttgt tttgactaaa tgcggcagtc aggtgttggc 34140cagcgtttct gttttatctg taaaaggtag ccttgcgccc atcagtggca cagtaactag 34200tgctcagatt gtcctcagat ttgatgaaaa tggagttcta ctaagcaatt cttcccttga 34260ccctcaatac tggaactaca gaaaaggtga ccttacagag ggcactgcat ataccaacgc 34320agtgggattt atgcccaacc tcacagcata cccaaaaaca cagagccaaa ctgctaaaag 34380caacattgta agtcaggttt acttgaatgg ggacaaatcc aaacccatga ccctcaccat 34440taccctcaat ggaactaatg aaacaggaga

tgccacagta agcacttact ccatgtcatt 34500ctcatggaac tggaatggaa gtaattacat taatgaaacg ttccaaacca actccttcac 34560cttctcctac atcgcccaag aataaaaagc atgacgctgt tgatttgatt caatgtgttt 34620ctgttttatt ttcaagcaca acaaaatcat tcaagtcatt cttccatctt agcttaatag 34680acacagtagc ttaatagacc cagtagtgca aagccccatt ctagcttata gatcagacag 34740tgataattaa ccaccaccac caccatacct tttgattcag gaaatcatga tcatcacagg 34800atcctagtct tcaggccgcc ccctccctcc caagacacag aatacacagt cctctccccc 34860cgactggctt taaataacac catctggttg gtcacagaca tgttcttagg ggttatattc 34920cacacggtct cctgccgcgc caggcgctcg tcggtgatgt tgataaactc tcccggcagc 34980tcgctcaagt tcacgtcgct gtccagcggc tgaacctccg gctgacgcga taactgtgcg 35040accggctgct ggacgaacgg aggccgcgcc tacaaggggg tagagtcata atcctcggtc 35100aggatagggc ggtgatgcag cagcagcgag cgaaacatct gctgccgccg ccgctccgtc 35160cggcaggaaa acaacacgcc ggtggtctcc tccgcgataa tccgcaccgc ccgcagcatc 35220agcttcctcg ttctccgcgc gcagcacctc acccttatct cgctcaaatc ggcgcagtag 35280gtacagcaca gcaccacgat gttattcatg atcccacagt gcagggcgct gtatccaaag 35340ctcatgccgg gaaccaccgc ccccacgtgg ccatcgtacc acaagcgcac gtaaatcaag 35400tgtcgacccc tcatgaacgc gctggacaca aacattactt ccttgggcat gttgtaattc 35460accacctccc ggtaccagat aaacctctgg ttgaacaggg caccttccac caccatcctg 35520aaccaagagg ccagaacctg cccaccggct atgcactgca gggaacccgg gttggaacaa 35580tgacaatgca gactccaagg ctcgtaaccg tggatcatcc ggctgctgaa ggcatcgatg 35640ttggcacaac acagacacac gtgcatgcac tttctcatga ttagcagctc ttccctcgtc 35700aggatcatat cccaaggaat aacccattct tgaatcaacg taaaacccac acagcaggga 35760aggcctcgca cataactcac gttgtgcatg gtcagcgtgt tgcattccgg aaacagcgga 35820tgatcctcca gtatcgaggc gcgggtctcc ttctcacagg gaggtaaagg gtccctgctg 35880tacggactgc gccgggacga ccgagatcgt gttgagcgta gtgtcatgga aaagggaacg 35940ccggacgtgg tcatacttct tgaagcagaa ccaggttcgc gcgtggcagg cctccttgcg 36000tctgcggtct cgccgtctag ctcgctccgt gtgatagttg tagtacagcc actcccgcag 36060agcgtcgagg cgcaccctgg cttccggatc tatgtagact ccgtcttgca ccgcggccct 36120gataatatcc accaccgtag aataagcaac acccagccaa gcaatacact cgctctgcga 36180gcggcagaca ggaggagcgg gcagagatgg gagaaccatg ataaaaaact ttttttaaag 36240aatattttcc aattcttcga aagtaagatc tatcaagtgg cagcgctccc ctccactggc 36300gcggtcaaac tctacggcca aagcacagac aacggcattt ctaagatgtt ccttaatggc 36360gtccaaaaga cacaccgctc tcaagttgca gtaaactatg aatgaaaacc catccggctg 36420attttccaat atagacgcgc cggcagcgtc caccaaaccc agataatttt cttctctcca 36480gcggtttacg atctgtctaa gcaaatccct tatatcaagt ccgaccatgc caaaaatctg 36540ctcaagagcg ccctccacct tcatgtacaa gcagcgcatc atgattgcaa aaattcaggt 36600tcttcagaga cctgtataag attcaaaatg ggaacattaa caaaaattcc tctgtcgcgc 36660agatcccttc gcagggcaag ctgaacataa tcagacaggt ccgaacggac cagtgaggcc 36720aaatccccac caggaaccag atccagagac cctatactga ttatgacgcg catactcggg 36780gctatgctga ccagcgtagc gccgatgtag gcgtgctgca tgggcggcga gataaaatgc 36840aaagtgctgg ttaaaaaatc aggcaaagcc tcgcgcaaaa aagctaacac atcataatca 36900tgctcatgca ggtagttgca ggtaagctca ggaaccaaaa cggaataaca cacgattttc 36960ctctcaaaca tgacttcgcg gatactgcgt aaaacaaaaa attataaata aaaaattaat 37020taaataactt aaacattgga agcctgtctc acaacaggaa aaaccacttt aatcaacata 37080agacgggcca cgggcatgcc ggcatagccg taaaaaaatt ggtccccgtg attaacaagt 37140accacagaca gctccccggt catgtcgggg gtcatcatgt gagactctgt atacacgtct 37200ggattgtgaa catcagacaa acaaagaaat cgagccacgt agcccggagg tataatcacc 37260cgcaggcgga ggtacagcaa aacgaccccc ataggaggaa tcacaaaatt agtaggagaa 37320aaaaatacat aaacaccaga aaaaccctgt tgctgaggca aaatagcgcc ctcccgatcc 37380aaaacaacat aaagcgcttc cacaggagca gccataacaa agacccgagt cttaccagta 37440aaagaaaaaa gatctctcaa cgcagcacca gcaccaacac ttcgcagtgt aaaaggccaa 37500gtgccgagag agtatatata ggaataaaaa gtgacgtaaa cgggcaaagt ccaaaaaacg 37560cccagaaaaa ccgcacgcga acctacgccc cgaaacgaaa gccaaaaaac actagacact 37620cccttccggc gtcaacttcc gctttcccac gctacgtcac ttcccccggt caaacaaact 37680acatatcccg aacttccaag tcgccacgcc caaaacaccg cctacacctc cccgcccgcc 37740ggcccgcccc cggacccgcc tcccgccccg cgccgcccat ctcattatca tattggcttc 37800aatccaaaat aaggtatatt attgatgatg 378301137559DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic polynucleotide" 11catcatcaat aatatacctt attttggatt gaagccaata tgataatgag atgggcggcg 60cggggcgggg cgcggggcgg gaggcgggtt tgggggcggg ccggcgggcg gggcggtgtg 120gcggaagtgg actttgtaag tgtggcggat gtgacttgct agtgccgggc gcggtaaaag 180tgacgttttc cgtgcgcgac aacgcccccg ggaagtgaca tttttcccgc ggtttttacc 240ggatgttgta gtgaatttgg gcgtaaccaa gtaagatttg gccattttcg cgggaaaact 300gaaacgggga agtgaaatct gattaatttt gcgttagtca taccgcgtaa tatttgtcta 360gggccgaggg actttggccg attacgtgga ggactcgccc aggtgttttt tgaggtgaat 420ttccgcgttc cgggtcaaag tctgcgtttt attattatag gatatcccat tgcatacgtt 480gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg 540acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 600atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 660cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 720tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 780agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 840gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 900agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 960gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 1020gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 1080gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag 1140agatctccct atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc 1200ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct 1260ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg agatcttccg 1320tttatctagg taccagatat cgccaccatg gaactgctga tcctgaaggc caacgccatc 1380accaccatcc tgaccgccgt gaccttctgc ttcgccagcg gccagaacat caccgaggaa 1440ttctaccaga gcacctgtag cgccgtgagc aagggctacc tgagcgccct gagaaccggc 1500tggtacacca gcgtgatcac catcgagctg agcaacatca aagaaaacaa gtgcaacggc 1560accgacgcca aagtgaagct gatcaagcag gaactggaca agtacaagaa cgccgtgacc 1620gagctgcagc tgctgatgca gagcaccccc gccaccaaca accgggccag acgggagctg 1680ccccggttca tgaactacac cctgaacaac gccaaaaaga ccaacgtgac cctgagcaag 1740aagcggaagc ggcggttcct gggctttctg ctgggcgtgg gcagcgccat tgccagcggc 1800gtggccgtgt ctaaggtgct gcacctggaa ggcgaagtga acaagatcaa gagcgccctg 1860ctgagcacca acaaggccgt ggtgtccctg agcaacggcg tgagcgtgct gaccagcaag 1920gtgctggatc tgaagaacta catcgacaag cagctgctgc ccatcgtgaa caagcagagc 1980tgcagcatca gcaacatcga gacagtgatc gagttccagc agaagaacaa ccggctgctg 2040gaaatcaccc gggagttcag cgtgaacgcc ggcgtgacca cccctgtgtc cacctacatg 2100ctgaccaaca gcgagctgct gagcctgatc aacgacatgc ccatcaccaa cgaccagaaa 2160aagctgatga gcaacaacgt gcagatcgtg cggcagcaga gctactccat catgtccatc 2220atcaaagaag aggtgctggc ctacgtggtg cagctgcccc tgtacggcgt gatcgacacc 2280ccctgctgga agctgcacac cagccccctg tgcaccacca acaccaaaga gggcagcaac 2340atctgcctga cccggaccga cagaggctgg tactgcgaca acgccggcag cgtgtcattc 2400tttccacagg ccgagacatg caaggtgcag agcaaccggg tgttctgcga caccatgaac 2460agcctgaccc tgccctccga agtgaacctg tgcaacgtgg acatcttcaa ccccaagtac 2520gactgcaaga tcatgacctc caagaccgac gtgtccagct ccgtgatcac ctccctgggc 2580gccatcgtgt cctgctacgg caagaccaag tgcaccgcca gcaacaagaa ccggggcatc 2640atcaagacct tcagcaacgg ctgcgactac gtgtccaaca agggggtgga caccgtgtcc 2700gtgggcaaca ccctgtacta cgtgaacaaa caggaaggca agagcctgta cgtgaagggc 2760gagcccatca tcaacttcta cgaccccctg gtgttcccca gcgacgagtt cgacgccagc 2820atcagccagg tgaacgagaa gatcaaccag agcctggcct tcatccggaa gtccgacgag 2880ctgctgcaca atgtgaatgc cggcaagtcc accaccaacc ggaagcggag agcccctgtg 2940aagcagaccc tgaacttcga cctgctgaag ctggccggcg acgtggagag caatcccggc 3000cctatggccc tgagcaaagt gaaactgaac gatacactga acaaggacca gctgctgtcc 3060agcagcaagt acaccatcca gcggagcacc ggcgacagca tcgatacccc caactacgac 3120gtgcagaagc acatcaacaa gctgtgcggc atgctgctga tcacagagga cgccaaccac 3180aagttcaccg gcctgatcgg catgctgtac gccatgagcc ggctgggccg ggaggacacc 3240atcaagatcc tgcgggacgc cggctaccac gtgaaggcca atggcgtgga cgtgaccaca 3300caccggcagg acatcaacgg caaagaaatg aagttcgagg tgctgaccct ggccagcctg 3360accaccgaga tccagatcaa tatcgagatc gagagccgga agtcctacaa gaaaatgctg 3420aaagaaatgg gcgaggtggc ccccgagtac agacacgaca gccccgactg cggcatgatc 3480atcctgtgta tcgccgccct ggtgatcaca aagctggccg ctggcgacag atctggcctg 3540acagccgtga tcagacgggc caacaatgtg ctgaagaacg agatgaagcg gtacaagggc 3600ctgctgccca aggacattgc caacagcttc tacgaggtgt tcgagaagta cccccacttc 3660atcgacgtgt tcgtgcactt cggcattgcc cagagcagca ccagaggcgg ctccagagtg 3720gagggcatct tcgccggcct gttcatgaac gcctacggcg ctggccaggt gatgctgaga 3780tggggcgtgc tggccaagag cgtgaagaac atcatgctgg gccacgccag cgtgcaggcc 3840gagatggaac aggtggtgga ggtgtacgag tacgcccaga agctgggcgg agaggccggc 3900ttctaccaca tcctgaacaa ccctaaggcc tccctgctgt ccctgaccca gttcccccac 3960ttctccagcg tggtgctggg aaatgccgcc ggactgggca tcatgggcga gtaccggggc 4020acccccagaa accaggacct gtacgacgcc gccaaggcct acgccgagca gctgaaagaa 4080aacggcgtga tcaactacag cgtgctggac ctgaccgctg aggaactgga agccatcaag 4140caccagctga accccaagga caacgacgtg gagctgggag gcggaggatc tggcggcgga 4200ggcatgagca gacggaaccc ctgcaagttc gagatccggg gccactgcct gaacggcaag 4260cggtgccact tcagccacaa ctacttcgag tggccccctc atgctctgct ggtgcggcag 4320aacttcatgc tgaaccggat cctgaagtcc atggacaaga gcatcgacac cctgagcgag 4380atcagcggag ccgccgagct ggacagaacc gaggaatatg ccctgggcgt ggtgggagtg 4440ctggaaagct acatcggctc catcaacaac atcacaaagc agagcgcctg cgtggccatg 4500agcaagctgc tgacagagct gaacagcgac gacatcaaga agctgaggga caacgaggaa 4560ctgaacagcc ccaagatccg ggtgtacaac accgtgatca gctacattga gagcaaccgc 4620aagaacaaca agcagaccat ccatctgctg aagcggctgc ccgccgacgt gctgaaaaag 4680accatcaaga acaccctgga catccacaag tccatcacca tcaacaatcc caaagaaagc 4740accgtgtctg acaccaacga tcacgccaag aacaacgaca ccacctgatg agcggccgcg 4800atctgctgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt 4860gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca 4920ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga 4980ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg ccgatcagcg 5040atcgctgagg tgggtgagtg ggcgtggcct ggggtggtca tgaaaatata taagttgggg 5100gtcttagggt ctctttattt gtgttgcaga gaccgccgga gccatgagcg ggagcagcag 5160cagcagcagt agcagcagcg ccttggatgg cagcatcgtg agcccttatt tgacgacgcg 5220gatgccccac tgggccgggg tgcgtcagaa tgtgatgggc tccagcatcg acggccgacc 5280cgtcctgccc gcaaattccg ccacgctgac ctatgcgacc gtcgcgggga cgccgttgga 5340cgccaccgcc gccgccgccg ccaccgcagc cgcctcggcc gtgcgcagcc tggccacgga 5400ctttgcattc ctgggaccac tggcgacagg ggctacttct cgggccgctg ctgccgccgt 5460tcgcgatgac aagctgaccg ccctgctggc gcagttggat gcgcttactc gggaactggg 5520tgacctttct cagcaggtca tggccctgcg ccagcaggtc tcctccctgc aagctggcgg 5580gaatgcttct cccacaaatg ccgtttaaga taaataaaac cagactctgt ttggattaaa 5640gaaaagtagc aagtgcattg ctctctttat ttcataattt tccgcgcgcg ataggcccta 5700gaccagcgtt ctcggtcgtt gagggtgcgg tgtatcttct ccaggacgtg gtagaggtgg 5760ctctggacgt tgagatacat gggcatgagc ccgtcccggg ggtggaggta gcaccactgc 5820agagcttcat gctccggggt ggtgttgtag atgatccagt cgtagcagga gcgctgggca 5880tggtgcctaa aaatgtcctt cagcagcagg ccgatggcca gggggaggcc cttggtgtaa 5940gtgtttacaa aacggttaag ttgggaaggg tgcattcggg gagagatgat gtgcatcttg 6000gactgtattt ttagattggc gatgtttccg cccagatccc ttctgggatt catgttgtgc 6060aggaccacca gtacagtgta tccggtgcac ttggggaatt tgtcatgcag cttagaggga 6120aaagcgtgga agaacttgga gacgcctttg tggcctccca gattttccat gcattcgtcc 6180atgatgatgg caatgggccc gcgggaggca gcttgggcaa agatatttct ggggtcgctg 6240acgtcgtagt tgtgttccag ggtgaggtcg tcataggcca tttttacaaa gcgcgggcgg 6300agggtgcccg actgggggat gatggtcccc tctggccctg gggcgtagtt gccctcgcag 6360atctgcattt cccaggcctt aatctcggag gggggaatca tatccacctg cggggcgatg 6420aagaaaacgg tttccggagc cggggagatt aactgggatg agagcaggtt tctaagcagc 6480tgtgattttc cacaaccggt gggcccataa ataacaccta taaccggttg cagctggtag 6540tttagagagc tgcagctgcc gtcgtcccgg aggagggggg ccacctcgtt gagcatgtcc 6600ctgacgcgca tgttctcccc gaccagatcc gccagaaggc gctcgccgcc cagggacagc 6660agctcttgca aggaagcaaa gtttttcagc ggcttgaggc cgtccgccgt gggcatgttt 6720ttcagggtct ggctcagcag ctccaggcgg tcccagagct cggtgacgtg ctctacggca 6780tctctatcca gcatatctcc tcgtttcgcg ggttggggcg actttcgctg tagggcacca 6840agcggtggtc gtccagcggg gccagagtca tgtccttcca tgggcgcagg gtcctcgtca 6900gggtggtctg ggtcacggtg aaggggtgcg ctccgggctg agcgcttgcc aaggtgcgct 6960tgaggctggt tctgctggtg ctgaagcgct gccggtcttc gccctgcgcg tcggccaggt 7020agcatttgac catggtgtca tagtccagcc cctccgcggc gtgtcccttg gcgcgcagct 7080tgcccttgga ggtggcgccg cacgaggggc agagcaggct cttgagcgcg tagagcttgg 7140gggcgaggaa gaccgattcg ggggagtagg cgtccgcgcc gcagaccccg cacacggtct 7200cgcactccac cagccaggtg agctcggggc gcgccgggtc aaaaaccagg tttcccccat 7260gctttttgat gcgtttctta cctcgggtct ccatgaggtg gtgtccccgc tcggtgacga 7320agaggctgtc cgtgtctccg tagaccgact tgaggggtct tttctccagg ggggtccctc 7380ggtcttcctc gtagaggaac tcggaccact ctgagacgaa ggcccgcgtc caggccagga 7440cgaaggaggc tatgtgggag gggtagcggt cgttgtccac tagggggtcc accttctcca 7500aggtgtgaag acacatgtcg ccttcctcgg cgtccaggaa ggtgattggc ttgtaggtgt 7560aggccacgtg accgggggtt cctgacgggg gggtataaaa gggggtgggg gcgcgctcgt 7620cgtcactctc ttccgcatcg ctgtctgcga gggccagctg ctggggtgag tattccctct 7680cgaaggcggg catgacctcc gcgctgaggt tgtcagtttc caaaaacgag gaggatttga 7740tgttcacctg tcccgaggtg atacctttga gggtacccgc gtccatctgg tcagaaaaca 7800cgatcttttt attgtccagc ttggtggcga acgacccgta gagggcgttg gagagcagct 7860tggcgatgga gcgcagggtc tggttcttgt ccctgtcggc gcgctccttg gccgcgatgt 7920tgagctgcac gtactcgcgc gcgacgcagc gccactcggg gaagacggtg gtgcgctcgt 7980cgggcaccag gcgcacgcgc cagccgcggt tgtgcagggt gaccaggtcc acgctggtgg 8040cgacctcgcc gcgcaggcgc tcgttggtcc agcagagacg gccgcccttg cgcgagcaga 8100aggggggcag ggggtcgagc tgggtctcgt ccggggggtc cgcgtccacg gtgaaaaccc 8160cggggcgcag gcgcgcgtcg aagtagtcta tcttgcaacc ttgcatgtcc agcgcctgct 8220gccagtcgcg ggcggcgagc gcgcgctcgt aggggttgag cggcgggccc cagggcatgg 8280ggtgggtgag tgcggaggcg tacatgccgc agatgtcata gacgtagagg ggctcccgca 8340ggaccccgat gtaggtgggg tagcagcggc cgccgcggat gctggcgcgc acgtagtcat 8400acagctcgtg cgagggggcg aggaggtcgg ggcccaggtt ggtgcgggcg gggcgctccg 8460cgcggaagac gatctgcctg aagatggcat gcgagttgga agagatggtg gggcgctgga 8520agacgttgaa gctggcgtcc tgcaggccga cggcgtcgcg cacgaaggag gcgtaggagt 8580cgcgcagctt gtgtaccagc tcggcggtga cctgcacgtc gagcgcgcag tagtcgaggg 8640tctcgcggat gatgtcatat ttagcctgcc ccttcttttt ccacagctcg cggttgagga 8700caaactcttc gcggtctttc cagtactctt ggatcgggaa accgtccggt tccgaacggt 8760aagagcctag catgtagaac tggttgacgg cctggtaggc gcagcagccc ttctccacgg 8820ggagggcgta ggcctgcgcg gccttgcgga gcgaggtgtg ggtcagggcg aaggtgtccc 8880tgaccatgac tttgaggtac tggtgcttga agtcggagtc gtcgcagccg ccccgctccc 8940agagcgagaa gtcggtgcgc ttcttggagc gggggttggg cagagcgaag gtgacatcgt 9000tgaagaggat tttgcccgcg cggggcatga agttgcgggt gatgcggaag ggccccggca 9060cttcagagcg gttgttgatg acctgggcgg cgagcacgat ctcgtcgaag ccgttgatgt 9120tgtggcccac gatgtagagt tccaggaagc ggggccggcc ctttacggtg ggcagcttct 9180ttagctcttc gtaggtgagc tcctcgggcg aggcgaggcc gtgctcggcc agggcccagt 9240ccgcgaggtg cgggttgtct ctgaggaagg acttccagag gtcgcgggcc aggagggtct 9300gcaggcggtc tctgaaggtc ctgaactggc ggcccacggc cattttttcg ggggtgatgc 9360agtagaaggt gagggggtct tgctgccagc ggtcccagtc gagctgcagg gcgaggtcgc 9420gcgcggcggt gaccaggcgc tcgtcgcccc cgaatttcat gaccagcatg aagggcacga 9480gctgctttcc gaaggccccc atccaagtgt aggtctctac atcgtaggtg acaaagaggc 9540gctccgtgcg aggatgcgag ccgatcggga agaactggat ctcccgccac cagttggagg 9600agtggctgtt gatgtggtgg aagtagaagt cccgtcgccg ggccgaacac tcgtgctggc 9660ttttgtaaaa gcgagcgcag tactggcagc gctgcacggg ctgtacctca tgcacgagat 9720gcacctttcg cccgcgcacg aggaagccga ggggaaatct gagccccccg cctggctcgc 9780ggcatggctg gttctcttct actttggatg cgtgtccgtc tccgtctggc tcctcgaggg 9840gtgttacggt ggagcggacc accacgccgc gcgagccgca ggtccagata tcggcgcgcg 9900gcggtcggag tttgatgacg acatcgcgca gctgggagct gtccatggtc tggagctccc 9960gcggcggcgg caggtcagcc gggagttctt gcaggttcac ctcgcagagt cgggccaggg 10020cgcggggcag gtctaggtgg tacctgatct ctaggggcgt gttggtggcg gcgtcgatgg 10080cttgcaggag cccgcagccc cggggggcga cgacggtgcc ccgcggggtg gtggtggtgg 10140tggcggtgca gctcagaagc ggtgccgcgg gcgggccccc ggaggtaggg ggggctccgg 10200tcccgcgggc aggggcggca gcggcacgtc ggcgtggagc gcgggcagga gttggtgctg 10260tgcccggagg ttgctggcga aggcgacgac gcggcggttg atctcctgga tctggcgcct 10320ctgcgtgaag acgacgggcc cggtgagctt gaacctgaaa gagagttcga cagaatcaat 10380ctcggtgtca ttgaccgcgg cctggcgcag gatctcctgc acgtctcccg agttgtcttg 10440gtaggcgatc tcggccatga actgctcgat ctcttcctcc tggaggtctc cgcgtccggc 10500gcgttccacg gtggccgcca ggtcgttgga gatgcgcccc atgagctgcg agaaggcgtt 10560gagtccgccc tcgttccaga ctcggctgta gaccacgccc ccctggtcat cgcgggcgcg 10620catgaccacc tgcgcgaggt tgagctccac gtgccgcgcg aagacggcgt agttgcgcag 10680acgctggaag aggtagttga gggtggtggc ggtgtgctcg gccacgaaga agttcatgac 10740ccagcggcgc aacgtggatt cgttgatgtc ccccaaggcc tccagccgtt ccatggcctc 10800gtagaagtcc acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg tcaactcctc 10860ctccagaaga cggatgagct cggcgacggt gtcgcgcacc tcgcgctcga aggctatggg 10920gatctcttcc tccgctagca tcaccacctc ctcctcttcc tcctcttctg gcacttccat 10980gatggcttcc tcctcttcgg ggggtggcgg cggcggcggt gggggagggg gcgctctgcg 11040ccggcggcgg cgcaccggga ggcggtccac gaagcgcgcg atcatctccc cgcggcggcg 11100gcgcatggtc tcggtgacgg cgcggccgtt ctcccggggg cgcagttgga agacgccgcc 11160ggacatctgg tgctggggcg ggtggccgtg aggcagcgag acggcgctga cgatgcatct 11220caacaattgc tgcgtaggta cgccgccgag ggacctgagg gagtccatat ccaccggatc 11280cgaaaacctt tcgaggaagg cgtctaacca gtcgcagtcg caaggtaggc tgagcaccgt 11340ggcgggcggc ggggggtggg gggagtgtct ggcggaggtg ctgctgatga tgtaattgaa 11400gtaggcggac ttgacacggc ggatggtcga caggagcacc atgtccttgg gtccggcctg 11460ctggatgcgg aggcggtcgg ctatgcccca ggcttcgttc tggcatcggc gcaggtcctt 11520gtagtagtct tgcatgagcc tttccaccgg cacctcttct ccttcctctt

ctgcttcttc 11580catgtctgct tcggccctgg ggcggcgccg cgcccccctg ccccccatgc gcgtgacccc 11640gaaccccctg agcggttgga gcagggccag gtcggcgacg acgcgctcgg ccaggatggc 11700ctgctgcacc tgcgtgaggg tggtttggaa gtcatccaag tccacgaagc ggtggtaggc 11760gcccgtgttg atggtgtagg tgcagttggc catgacggac cagttgacgg tctggtggcc 11820cggttgcgac atctcggtgt acctgagtcg cgagtaggcg cgggagtcga agacgtagtc 11880gttgcaagtc cgcaccaggt actggtagcc caccaggaag tgcggcggcg gctggcggta 11940gaggggccag cgcagggtgg cgggggctcc gggggccagg tcttccagca tgaggcggtg 12000gtaggcgtag atgtacctgg acatccaggt gatacccgcg gcggtggtgg aggcgcgcgg 12060gaagtcgcgc acccggttcc agatgttgcg caggggcaga aagtgctcca tggtaggcgt 12120gctctgtcca gtcagacgcg cgcagtcgtt gatactctag accagggaaa acgaaagccg 12180gtcagcgggc actcttccgt ggtctggtga atagatcgca agggtatcat ggcggagggc 12240ctcggttcga gccccgggtc cgggccggac ggtccgccat gatccacgcg gttaccgccc 12300gcgtgtcgaa cccaggtgtg cgacgtcaga caacggtgga gtgttccttt tggcgttttt 12360ctggccgggc gccggcgccg cgtaagagac taagccgcga aagcgaaagc agtaagtggc 12420tcgctccccg tagccggagg gatccttgct aagggttgcg ttgcggcgaa ccccggttcg 12480aatcccgtac tcgggccggc cggacccgcg gctaaggtgt tggattggcc tccccctcgt 12540ataaagaccc cgcttgcgga ttgactccgg acacggggac gagccccttt tatttttgct 12600ttccccagat gcatccggtg ctgcggcaga tgcgcccccc gccccagcag cagcaacaac 12660accagcaaga gcggcagcaa cagcagcggg agtcatgcag ggccccctca cccaccctcg 12720gcgggccggc cacctcggcg tccgcggccg tgtctggcgc ctgcggcggc ggcggggggc 12780cggctgacga ccccgaggag cccccgcggc gcagggccag acactacctg gacctggagg 12840agggcgaggg cctggcgcgg ctgggggcgc cgtctcccga gcgccacccg cgggtgcagc 12900tgaagcgcga ctcgcgcgag gcgtacgtgc ctcggcagaa cctgttcagg gaccgcgcgg 12960gcgaggagcc cgaggagatg cgggacagga ggttcagcgc agggcgggag ctgcggcagg 13020ggctgaaccg cgagcggctg ctgcgcgagg aggactttga gcccgacgcg cggacgggga 13080tcagccccgc gcgcgcgcac gtggcggccg ccgacctggt gacggcgtac gagcagacgg 13140tgaaccagga gatcaacttc caaaagagtt tcaacaacca cgtgcgcacg ctggtggcgc 13200gcgaggaggt gaccatcggg ctgatgcacc tgtgggactt tgtaagcgcg ctggtgcaga 13260accccaacag caagcctctg acggcgcagc tgttcctgat agtgcagcac agcagggaca 13320acgaggcgtt tagggacgcg ctgctgaaca tcaccgagcc cgagggtcgg tggctgctgg 13380acctgattaa catcctgcag agcatagtgg tgcaggagcg cagcctgagc ctggccgaca 13440aggtggcggc catcaactac tcgatgctga gcctgggcaa gttttacgcg cgcaagatct 13500accagacgcc gtacgtgccc atagacaagg aggtgaagat cgacggtttt tacatgcgca 13560tggcgctgaa ggtgctcacc ctgagcgacg acctgggcgt gtaccgcaac gagcgcatcc 13620acaaggccgt gagcgtgagc cggcggcgcg agctgagcga ccgcgagctg atgcacagcc 13680tgcagcgggc gctggcgggc gccggcagcg gcgacaggga ggcggagtcc tacttcgatg 13740cgggggcgga cctgcgctgg gcgcccagcc ggcgggccct ggaggccgcg ggggtccgcg 13800aggactatga cgaggacggc gaggaggatg aggagtacga gctagaggag ggcgagtacc 13860tggactaaac cgcgggtggt gtttccggta gatgcaagac ccgaacgtgg tggacccggc 13920gctgcgggcg gctctgcaga gccagccgtc cggccttaac tcctcagacg actggcgaca 13980ggtcatggac cgcatcatgt cgctgacggc gcgtaacccg gacgcgttcc ggcagcagcc 14040gcaggccaac aggctctccg ccatcctgga ggcggtggtg cctgcgcgct cgaaccccac 14100gcacgagaag gtgctggcca tagtgaacgc gctggccgag aacagggcca tccgcccgga 14160cgaggccggg ctggtgtacg acgcgctgct gcagcgcgtg gcccgctaca acagcggcaa 14220cgtgcagacc aacctggacc ggctggtggg ggacgtgcgc gaggcggtgg cgcagcgcga 14280gcgcgcggat cggcagggca acctgggctc catggtggcg ctgaatgcct tcctgagcac 14340gcagccggcc aacgtgccgc gggggcagga agactacacc aactttgtga gcgcgctgcg 14400gctgatggtg accgagaccc cccagagcga ggtgtaccag tcgggcccgg actacttctt 14460ccagaccagc agacagggcc tgcagacggt gaacctgagc caggctttca agaacctgcg 14520ggggctgtgg ggcgtgaagg cgcccaccgg cgaccgggcg acggtgtcca gcctgctgac 14580gcccaactcg cgcctgctgc tgctgctgat cgcgccgttc acggacagcg gcagcgtgtc 14640ccgggacacc tacctggggc acctgctgac cctgtaccgc gaggccatcg ggcaggcgca 14700ggtggacgag cacaccttcc aggagatcac cagcgtgagc cgcgcgctgg ggcaggagga 14760cacgagcagc ctggaggcga ctctgaacta cctgctgacc aaccggcggc agaagattcc 14820ctcgctgcac agcctgacct ccgaggagga gcgcatcttg cgctacgtgc agcagagcgt 14880gagcctgaac ctgatgcgcg acggggtgac gcccagcgtg gcgctggaca tgaccgcgcg 14940caacatggaa ccgggcatgt acgccgcgca ccggccttac atcaaccgcc tgatggacta 15000cctgcatcgc gcggcggccg tgaaccccga gtactttacc aacgccatcc tgaacccgca 15060ctggctcccg ccgcccgggt tctacagcgg gggcttcgag gtcccggaga ccaacgatgg 15120cttcctgtgg gacgacatgg acgacagcgt gttctccccg cggccgcagg cgctggcgga 15180agcgtccctg ctgcgtccca agaaggagga ggaggaggag gcgagtcgcc gccgcggcag 15240cagcggcgtg gcttctctgt ccgagctggg ggcggcagcc gccgcgcgcc ccgggtccct 15300gggcggcagc ccctttccga gcctggtggg gtctctgcac agcgagcgca ccacccgccc 15360tcggctgctg ggcgaggacg agtacctgaa taactccctg ctgcagccgg tgcgggagaa 15420aaacctgcct cccgccttcc ccaacaacgg gatagagagc ctggtggaca agatgagcag 15480atggaagacc tatgcgcagg agcacaggga cgcgcctgcg ctccggccgc ccacgcggcg 15540ccagcgccac gaccggcagc gggggctggt gtgggatgac gaggactccg cggacgatag 15600cagcgtgctg gacctgggag ggagcggcaa cccgttcgcg cacctgcgcc cccgcctggg 15660gaggatgttt taaaaaaaaa aaaaaaaagc aagaagcatg atgcaaaaat taaataaaac 15720tcaccaaggc catggcgacc gagcgttggt ttcttgtgtt cccttcagta tgcggcgcgc 15780ggcgatgtac caggagggac ctcctccctc ttacgagagc gtggtgggcg cggcggcggc 15840ggcgccctct tctccctttg cgtcgcagct gctggagccg ccgtacgtgc ctccgcgcta 15900cctgcggcct acggggggga gaaacagcat ccgttactcg gagctggcgc ccctgttcga 15960caccacccgg gtgtacctgg tggacaacaa gtcggcggac gtggcctccc tgaactacca 16020gaacgaccac agcaattttt tgaccacggt catccagaac aatgactaca gcccgagcga 16080ggccagcacc cagaccatca atctggatga ccggtcgcac tggggcggcg acctgaaaac 16140catcctgcac accaacatgc ccaacgtgaa cgagttcatg ttcaccaata agttcaaggc 16200gcgggtgatg gtgtcgcgct cgcacaccaa ggaagaccgg gtggagctga agtacgagtg 16260ggtggagttc gagctgccag agggcaacta ctccgagacc atgaccattg acctgatgaa 16320caacgcgatc gtggagcact atctgaaagt gggcaggcag aacggggtcc tggagagcga 16380catcggggtc aagttcgaca ccaggaactt ccgcctgggg ctggaccccg tgaccgggct 16440ggttatgccc ggggtgtaca ccaacgaggc cttccatccc gacatcatcc tgctgcccgg 16500ctgcggggtg gacttcactt acagccgcct gagcaacctc ctgggcatcc gcaagcggca 16560gcccttccag gagggcttca ggatcaccta cgaggacctg gaggggggca acatccccgc 16620gctcctcgat gtggaggcct accaggatag cttgaaggaa aatgaggcgg gacaggagga 16680taccgccccc gccgcctccg ccgccgccga gcagggcgag gatgctgctg acaccgcggc 16740cgcggacggg gcagaggccg accccgctat ggtggtggag gctcccgagc aggaggagga 16800catgaatgac agtgcggtgc gcggagacac cttcgtcacc cggggggagg aaaagcaagc 16860ggaggccgag gccgcggccg aggaaaagca actggcggca gcagcggcgg cggcggcgtt 16920ggccgcggcg gaggctgagt ctgaggggac caagcccgcc aaggagcccg tgattaagcc 16980cctgaccgaa gatagcaaga agcgcagtta caacctgctc aaggacagca ccaacaccgc 17040gtaccgcagc tggtacctgg cctacaacta cggcgacccg tcgacggggg tgcgctcctg 17100gaccctgctg tgcacgccgg acgtgacctg cggctcggag caggtgtact ggtcgctgcc 17160cgacatgatg caagaccccg tgaccttccg ctccacgcgg caggtcagca acttcccggt 17220ggtgggcgcc gagctgctgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 17280ctcccagctc atccgccagt tcacctctct gacccacgtg ttcaatcgct ttcctgagaa 17340ccagattctg gcgcgcccgc ccgcccccac catcaccacc gtcagtgaaa acgttcctgc 17400tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac 17460cgttactgac gccagacgcc gcacctgccc ctacgtttac aaggccttgg gcatagtctc 17520gccgcgcgtc ctttccagcc gcactttttg agcaacacca ccatcatgtc catcctgatc 17580tcacccagca ataactccgg ctggggactg ctgcgcgcgc ccagcaagat gttcggaggg 17640gcgaggaagc gttccgagca gcaccccgtg cgcgtgcgcg ggcacttccg cgccccctgg 17700ggagcgcaca aacgcggccg cgcggggcgc accaccgtgg acgacgccat cgactcggtg 17760gtggagcagg cgcgcaacta caggcccgcg gtctctaccg tggacgcggc catccagacc 17820gtggtgcggg gcgcgcggcg gtacgccaag ctgaagagcc gccggaagcg cgtggcccgc 17880cgccaccgcc gccgacccgg ggccgccgcc aaacgcgccg ccgcggccct gcttcgccgg 17940gccaagcgca cgggccgccg cgccgccatg agggccgcgc gccgcttggc cgccggcatc 18000accgccgcca ccatggcccc ccgtacccga agacgcgcgg ccgccgccgc cgccgccgcc 18060atcagtgaca tggccagcag gcgccggggc aacgtgtact gggtgcgcga ctcggtgacc 18120ggcacgcgcg tgcccgtgcg cttccgcccc ccgcggactt gagatgatgt gaaaaaacaa 18180cactgagtct cctgctgttg tgtgtatccc agcggcggcg gcgcgcgcag cgtcatgtcc 18240aagcgcaaaa tcaaagaaga gatgctccag gtcgtcgcgc cggagatcta tgggcccccg 18300aagaaggaag agcaggattc gaagccccgc aagataaagc gggtcaaaaa gaaaaagaaa 18360gatgatgacg atgccgatgg ggaggtggag ttcctgcgcg ccacggcgcc caggcgcccg 18420gtgcagtgga agggccggcg cgtaaagcgc gtcctgcgcc ccggcaccgc ggtggtcttc 18480acgcccggcg agcgctccac ccggactttc aagcgcgtct atgacgaggt gtacggcgac 18540gaagacctgc tggagcaggc caacgagcgc ttcggagagt ttgcttacgg gaagcgtcag 18600cgggcgctgg ggaaggagga cctgctggcg ctgccgctgg accagggcaa ccccaccccc 18660agtctgaagc ccgtgaccct gcagcaggtg ctgccgagca gcgcaccctc cgaggcgaag 18720cggggtctga agcgcgaggg cggcgacctg gcgcccaccg tgcagctcat ggtgcccaag 18780cggcagaggc tggaggatgt gctggagaaa atgaaagtag accccggtct gcagccggac 18840atcagggtcc gccccatcaa gcaggtggcg ccgggcctcg gcgtgcagac cgtggacgtg 18900gtcatcccca ccggcaactc ccccgccgcc gccaccacta ccgctgcctc cacggacatg 18960gagacacaga ccgatcccgc cgcagccgca gccgcagccg ccgccgcgac ctcctcggcg 19020gaggtgcaga cggacccctg gctgccgccg gcgatgtcag ctccccgcgc gcgtcgcggg 19080cgcaggaagt acggcgccgc caacgcgctc ctgcccgagt acgccttgca tccttccatc 19140gcgcccaccc ccggctaccg aggctatacc taccgcccgc gaagagccaa gggttccacc 19200cgccgtcccc gccgacgcgc cgccgccacc acccgccgcc gccgccgcag acgccagccc 19260gcactggctc cagtctccgt gaggaaagtg gcgcgcgacg gacacaccct ggtgctgccc 19320agggcgcgct accaccccag catcgtttaa aagcctgttg tggttcttgc agatatggcc 19380ctcacttgcc gcctccgttt cccggtgccg ggataccgag gaggaagatc gcgccgcagg 19440aggggtctgg ccggccgcgg cctgagcgga ggcagccgcc gcgcgcaccg gcggcgacgc 19500gccaccagcc gacgcatgcg cggcggggtg ctgcccctgt taatccccct gatcgccgcg 19560gcgatcggcg ccgtgcccgg gatcgcctcc gtggccttgc aagcgtccca gaggcattga 19620cagacttgca aacttgcaaa tatggaaaaa aaaaccccaa taaaaaagtc tagactctca 19680cgctcgcttg gtcctgtgac tattttgtag aatggaagac atcaactttg cgtcgctggc 19740cccgcgtcac ggctcgcgcc cgttcctggg acactggaac gatatcggca ccagcaacat 19800gagcggtggc gccttcagtt ggggctctct gtggagcggc attaaaagta tcgggtctgc 19860cgttaaaaat tacggctccc gggcctggaa cagcagcacg ggccagatgt tgagagacaa 19920gttgaaagag cagaacttcc agcagaaggt ggtggagggc ctggcctccg gcatcaacgg 19980ggtggtggac ctggccaacc aggccgtgca gaataagatc aacagcagac tggacccccg 20040gccgccggtg gaggaggtgc cgccggcgct ggagacggtg tcccccgatg ggcgtggcga 20100gaagcgcccg cggcccgata gggaagagac cactctggtc acgcagaccg atgagccgcc 20160cccgtatgag gaggccctga agcaaggtct gcccaccacg cggcccatcg cgcccatggc 20220caccggggtg gtgggccgcc acacccccgc cacgctggac ttgcctccgc ccgccgatgt 20280gccgcagcag cagaaggcgg cacagccggg cccgcccgcg accgcctccc gttcctccgc 20340cggtcctctg cgccgcgcgg ccagcggccc ccgcgggggg gtcgcgaggc acggcaactg 20400gcagagcacg ctgaacagca tcgtgggtct gggggtgcgg tccgtgaagc gccgccgatg 20460ctactgaata gcttagctaa cgtgttgtat gtgtgtatgc gccctatgtc gccgccagag 20520gagctgctga gtcgccgccg ttcgcgcgcc caccaccacc gccactccgc ccctcaagat 20580ggcgacccca tcgatgatgc cgcagtggtc gtacatgcac atctcgggcc aggacgcctc 20640ggagtacctg agccccgggc tggtgcagtt cgcccgcgcc accgagagct acttcagcct 20700gagtaacaag tttaggaacc ccacggtggc gcccacgcac gatgtgacca ccgaccggtc 20760tcagcgcctg acgctgcggt tcattcccgt ggaccgcgag gacaccgcgt actcgtacaa 20820ggcgcggttc accctggccg tgggcgacaa ccgcgtgctg gacatggcct ccacctactt 20880tgacatccgc ggggtgctgg accggggtcc cactttcaag ccctactctg gcaccgccta 20940caactccctg gcccccaagg gcgctcccaa ctcctgcgag tgggagcaag aggaaactca 21000ggcagttgaa gaagcagcag aagaggaaga agaagatgct gacggtcaag ctgaggaaga 21060gcaagcagct accaaaaaga ctcatgtata tgctcaggct cccctttctg gcgaaaaaat 21120tagtaaagat ggtctgcaaa taggaacgga cgctacagct acagaacaaa aacctattta 21180tgcagaccct acattccagc ccgaacccca aatcggggag tcccagtgga atgaggcaga 21240tgctacagtc gccggcggta gagtgctaaa gaaatctact cccatgaaac catgctatgg 21300ttcctatgca agacccacaa atgctaatgg aggtcagggt gtactaacgg caaatgccca 21360gggacagcta gaatctcagg ttgaaatgca attcttttca acttctgaaa acgcccgtaa 21420cgaggctaac aacattcagc ccaaattggt gctgtatagt gaggatgtgc acatggagac 21480cccggatacg cacctttctt acaagcccgc aaaaagcgat gacaattcaa aaatcatgct 21540gggtcagcag tccatgccca acagacctaa ttacatcggc ttcagagaca actttatcgg 21600cctcatgtat tacaatagca ctggcaacat gggagtgctt gcaggtcagg cctctcagtt 21660gaatgcagtg gtggacttgc aagacagaaa cacagaactg tcctaccagc tcttgcttga 21720ttccatgggt gacagaacca gatacttttc catgtggaat caggcagtgg acagttatga 21780cccagatgtt agaattattg aaaatcatgg aactgaagac gagctcccca actattgttt 21840ccctctgggt ggcatagggg taactgacac ttaccaggct gttaaaacca acaatggcaa 21900taacgggggc caggtgactt ggacaaaaga tgaaactttt gcagatcgca atgaaatagg 21960ggtgggaaac aatttcgcta tggagatcaa cctcagtgcc aacctgtgga gaaacttcct 22020gtactccaac gtggcgctgt acctaccaga caagcttaag tacaacccct ccaatgtgga 22080catctctgac aaccccaaca cctacgatta catgaacaag cgagtggtgg ccccggggct 22140ggtggactgc tacatcaacc tgggcgcgcg ctggtcgctg gactacatgg acaacgtcaa 22200ccccttcaac caccaccgca atgcgggcct gcgctaccgc tccatgctcc tgggcaacgg 22260gcgctacgtg cccttccaca tccaggtgcc ccagaagttc tttgccatca agaacctcct 22320cctcctgccg ggctcctaca cctacgagtg gaacttcagg aaggatgtca acatggtcct 22380ccagagctct ctgggtaacg atctcagggt ggacggggcc agcatcaagt tcgagagcat 22440ctgcctctac gccaccttct tccccatggc ccacaacacg gcctccacgc tcgaggccat 22500gctcaggaac gacaccaacg accagtcctt caatgactac ctctccgccg ccaacatgct 22560ctaccccata cccgccaacg ccaccaacgt ccccatctcc atcccctcgc gcaactgggc 22620ggccttccgc ggctgggcct tcacccgcct caagaccaag gagaccccct ccctgggctc 22680gggattcgac ccctactaca cctactcggg ctccattccc tacctggacg gcaccttcta 22740cctcaaccac actttcaaga aggtctcggt caccttcgac tcctcggtca gctggccggg 22800caacgaccgt ctgctcaccc ccaacgagtt cgagatcaag cgctcggtcg acggggaggg 22860ctacaacgtg gcccagtgca acatgaccaa ggactggttc ctggtccaga tgctggccaa 22920ctacaacatc ggctaccagg gcttctacat cccagagagc tacaaggaca ggatgtactc 22980cttcttcagg aacttccagc ccatgagccg gcaggtggtg gaccagacca agtacaagga 23040ctaccaggag gtgggcatca tccaccagca caacaactcg ggcttcgtgg gctacctcgc 23100ccccaccatg cgcgagggac aggcctaccc cgccaacttc ccctatccgc tcataggcaa 23160gaccgcggtc gacagcatca cccagaaaaa gttcctctgc gaccgcaccc tctggcgcat 23220ccccttctcc agcaacttca tgtccatggg tgcgctctcg gacctgggcc agaacttgct 23280ctacgccaac tccgcccacg ccctcgacat gaccttcgag gtcgacccca tggacgagcc 23340cacccttctc tatgttctgt tcgaagtctt tgacgtggtc cgggtccacc agccgcaccg 23400cggcgtcatc gagaccgtgt acctgcgtac gcccttctcg gccggcaacg ccaccaccta 23460aagaagcaag ccgcagtcat cgccgcctgc atgccgtcgg gttccaccga gcaagagctc 23520agggccatcg tcagagacct gggatgcggg ccctattttt tgggcacctt cgacaagcgc 23580ttccctggct ttgtctcccc acacaagctg gcctgcgcca tcgtcaacac ggccggccgc 23640gagaccgggg gcgtgcactg gctggccttc gcctggaacc cgcgctccaa aacatgcttc 23700ctctttgacc ccttcggctt ttcggaccag cggctcaagc aaatctacga gttcgagtac 23760gagggcttgc tgcgtcgcag cgccatcgcc tcctcgcccg accgctgcgt caccctcgaa 23820aagtccaccc agaccgtgca ggggcccgac tcggccgcct gcggtctctt ctgctgcatg 23880tttctgcacg cctttgtgca ctggcctcag agtcccatgg accgcaaccc caccatgaac 23940ttgctgacgg gggtgcccaa ctccatgctc cagagccccc aggtcgagcc caccctgcgc 24000cgcaaccagg agcagctcta cagcttcctg gagcgccact cgccttactt ccgccgccac 24060agcgcacaga tcaggagggc cacctccttc tgccacttgc aagagatgca agaagggtaa 24120taacgatgta cacacttttt ttctcaataa atggcatctt tttatttata caagctctct 24180ggggtattca tttcccacca ccacccgccg ttgtcgccat ctggctctat ttagaaatcg 24240aaagggttct gccgggagtc gccgtgcgcc acgggcaggg acacgttgcg atactggtag 24300cgggtgcccc acttgaactc gggcaccacc aggcgaggca gctcggggaa gttttcgctc 24360cacaggctgc gggtcagcac cagcgcgttc atcaggtcgg gcgccgagat cttgaagtcg 24420cagttggggc cgccgccctg cgcgcgcgag ttgcggtaca ccgggttgca gcactggaac 24480accaacagcg ccgggtgctt cacgctggcc agcacgctgc ggtcggagat cagctcggcg 24540tccaggtcct ccgcgttgct cagcgcgaac ggggtcatct tgggcacttg ccgccccagg 24600aagggcgcgt gccccggttt cgagttgcag tcgcagcgca gcgggatcag caggtgcccg 24660tgcccggact cggcgttggg gtacagcgcg cgcatgaagg cctgcatctg gcggaaggcc 24720atctgggcct tggcgccctc cgagaagaac atgccgcagg acttgcccga gaactggttt 24780gcggggcagc tggcgtcgtg caggcagcag cgcgcgtcgg tgttggcgat ctgcaccacg 24840ttgcgccccc accggttctt cacgatcttg gccttggacg attgctcctt cagcgcgcgc 24900tgcccgttct cgctggtcac atccatctcg atcacatgtt ccttgttcac catgctgctg 24960ccgtgcagac acttcagctc gccctccgtc tcggtgcagc ggtgctgcca cagcgcgcag 25020cccgtgggct cgaaagactt gtaggtcacc tccgcgaagg actgcaggta cccctgcaaa 25080aagcggccca tcatggtcac gaaggtcttg ttgctgctga aggtcagctg cagcccgcgg 25140tgctcctcgt tcagccaggt cttgcacacg gccgccagcg cctccacctg gtcgggcagc 25200atcttgaagt tcaccttcag ctcattctcc acgtggtact tgtccatcag cgtgcgcgcc 25260gcctccatgc ccttctccca ggccgacacc agcggcaggc tcacggggtt cttcaccatc 25320accgtggccg ccgcctccgc cgcgctttcg ctttccgccc cgctgttctc ttcctcttcc 25380tcctcttcct cgccgccgcc cactcgcagc ccccgcacca cggggtcgtc ttcctgcagg 25440cgctgcacct tgcgcttgcc gttgcgcccc tgcttgatgc gcacgggcgg gttgctgaag 25500cccaccatca ccagcgcggc ctcttcttgc tcgtcctcgc tgtccagaat gacctccggg 25560gagggggggt tggtcatcct cagtaccgag gcacgcttct ttttcttcct gggggcgttc 25620gccagctccg cggctgcggc cgctgccgag gtcgaaggcc gagggctggg cgtgcgcggc 25680accagcgcgt cctgcgagcc gtcctcgtcc tcctcggact cgagacggag gcgggcccgc 25740ttcttcgggg gcgcgcgggg cggcggaggc ggcggcggcg acggagacgg ggacgagaca 25800tcgtccaggg tgggtggacg gcgggccgcg ccgcgtccgc gctcgggggt ggtctcgcgc 25860tggtcctctt cccgactggc catctcccac tgctccttct cctataggca gaaagagatc 25920atggagtctc tcatgcgagt cgagaaggag gaggacagcc taaccgcccc ctctgagccc 25980tccaccaccg ccgccaccac cgccaatgcc gccgcggacg acgcgcccac cgagaccacc 26040gccagtacca ccctccccag cgacgcaccc ccgctcgaga atgaagtgct gatcgagcag 26100gacccgggtt ttgtgagcgg agaggaggat gaggtggatg agaaggagaa ggaggaggtc 26160gccgcctcag tgccaaaaga ggataaaaag caagaccagg acgacgcaga taaggatgag 26220acagcagtcg ggcgggggaa cggaagccat gatgctgatg acggctacct agacgtggga 26280gacgacgtgc tgcttaagca cctgcaccgc cagtgcgtca tcgtctgcga cgcgctgcag 26340gagcgctgcg aagtgcccct ggacgtggcg gaggtcagcc gcgcctacga gcggcacctc 26400ttcgcgccgc acgtgccccc caagcgccgg gagaacggca cctgcgagcc caacccgcgt 26460ctcaacttct acccggtctt cgcggtaccc gaggtgctgg ccacctacca catctttttc 26520caaaactgca agatccccct ctcctgccgc gccaaccgca cccgcgccga caaaaccctg 26580accctgcggc agggcgccca catacctgat atcgcctctc tggaggaagt

gcccaagatc 26640ttcgagggtc tcggtcgcga cgagaaacgg gcggcgaacg ctctgcacgg agacagcgaa 26700aacgagagtc actcgggggt gctggtggag ctcgagggcg acaacgcgcg cctggccgta 26760ctcaagcgca gcatagaggt cacccacttt gcctacccgg cgctcaacct gccccccaag 26820gtcatgagtg tggtcatggg cgagctcatc atgcgccgcg cccagcccct ggccgcggat 26880gcaaacttgc aagagtcctc cgaggaaggc ctgcccgcgg tcagcgacga gcagctggcg 26940cgctggctgg agacccgcga ccccgcgcag ctggaggagc ggcgcaagct catgatggcc 27000gcggtgctgg tcaccgtgga gctcgagtgt ctgcagcgct tcttcgcgga ccccgagatg 27060cagcgcaagc tcgaggagac cctgcactac accttccgcc agggctacgt gcgccaggcc 27120tgcaagatct ccaacgtgga gctctgcaac ctggtctcct acctgggcat cctgcacgag 27180aaccgcctcg ggcagaacgt cctgcactcc accctcaaag gggaggcgcg ccgcgactac 27240atccgcgact gcgcctacct cttcctctgc tacacctggc agacggccat gggggtctgg 27300cagcagtgcc tggaggagcg caacctcaag gagctggaaa agctcctcaa gcgcaccctc 27360agggacctct ggacgggctt caacgagcgc tcggtggccg ccgcgctggc ggacatcatc 27420tttcccgagc gcctgctcaa gaccctgcag cagggcctgc ccgacttcac cagccagagc 27480atgctgcaga acttcaggac tttcatcctg gagcgctcgg gcatcctgcc ggccacttgc 27540tgcgcgctgc ccagcgactt cgtgcccatc aagtacaggg agtgcccgcc gccgctctgg 27600ggccactgct acctcttcca gctggccaac tacctcgcct accactcgga cctcatggaa 27660gacgtgagcg gcgagggcct gctcgagtgc cactgccgct gcaacctctg cacgccccac 27720cgctctctag tctgcaaccc gcagctgctc agcgagagtc agattatcgg taccttcgag 27780ctgcagggtc cctcgcctga cgagaagtcc gcggctccag ggctgaaact cactccgggg 27840ctgtggactt ccgcctacct acgcaaattt gtacctgagg actaccacgc ccacgagatc 27900aggttctacg aagaccaatc ccgcccgccc aaggcggagc tcaccgcctg cgtcatcacc 27960caggggcaca tcctgggcca attgcaagcc atcaacaaag cccgccgaga gttcttgctg 28020aaaaagggtc ggggggtgta cctggacccc cagtccggcg aggagctaaa cccgctaccc 28080ccgccgccgc cccagcagcg ggaccttgct tcccaggatg gcacccagaa agaagcagca 28140gccgccgccg ccgccgcagc catacatgct tctggaggaa gaggaggagg actgggacag 28200tcaggcagag gaggtttcgg acgaggagca ggaggagatg atggaagact gggaggagga 28260cagcagccta gacgaggaag cttcagaggc cgaagaggtg gcagacgcaa caccatcgcc 28320ctcggtcgca gccccctcgc cggggcccct gaaatcctcc gaacccagca ccagcgctat 28380aacctccgct cctccggcgc cggcgccacc cgcccgcaga cccaaccgta gatgggacac 28440cacaggaacc ggggtcggta agtccaagtg cccgccgccg ccaccgcagc agcagcagca 28500gcagcgccag ggctaccgct cgtggcgcgg gcacaagaac gccatagtcg cctgcttgca 28560agactgcggg ggcaacatct ctttcgcccg ccgcttcctg ctattccacc acggggtcgc 28620ctttccccgc aatgtcctgc attactaccg tcatctctac agcccctact gcagcggcga 28680cccagaggcg gcagcggcag ccacagcggc gaccaccacc taggaagata tcctccgcgg 28740gcaagacagc ggcagcagcg gccaggagac ccgcggcagc agcggcggga gcggtgggcg 28800cactgcgcct ctcgcccaac gaacccctct cgacccggga gctcagacac aggatcttcc 28860ccactttgta tgccatcttc caacagagca gaggccagga gcaggagctg aaaataaaaa 28920acagatctct gcgctccctc acccgcagct gtctgtatca caaaagcgaa gatcagcttc 28980ggcgcacgct ggaggacgcg gaggcactct tcagcaaata ctgcgcgctc actcttaaag 29040actagctccg cgcccttctc gaatttaggc gggagaaaac tacgtcatcg ccggccgccg 29100cccagcccgc ccagccgaga tgagcaaaga gattcccacg ccatacatgt ggagctacca 29160gccgcagatg ggactcgcgg cgggagcggc ccaggactac tccacccgca tgaactacat 29220gagcgcggga ccccacatga tctcacaggt caacgggatc cgcgcccagc gaaaccaaat 29280actgctggaa caggcggcca tcaccgccac gccccgccat aatctcaacc cccgaaattg 29340gcccgccgcc ctcgtgtacc aggaaacccc ctccgccacc accgtactac ttccgcgtga 29400cgcccaggcc gaagtccaga tgactaactc aggggcgcag ctcgcgggcg gctttcgtca 29460cggggcgcgg ccgctccgac caggtataag acacctgatg atcagaggcc gaggtatcca 29520gctcaacgac gagtcggtga gctcttcgct cggtctccgt ccggacggaa ctttccagct 29580cgccggatcc ggccgctctt cgttcacgcc ccgccaggcg tacctgactc tgcagacctc 29640gtcctcggag ccccgctccg gcggcatcgg aaccctccag ttcgtggagg agttcgtgcc 29700ctcggtctac ttcaacccct tctcgggacc tcccggacgc taccccgacc agttcattcc 29760gaactttgac gcggtgaagg actcggcgga cggctacgac tgaatgtcag gtgtcgaggc 29820agagcagctt cgcctgagac acctcgagca ctgccgccgc cacaagtgct tcgcccgcgg 29880ttctggtgag ttctgctact ttcagctacc cgaggagcat accgaggggc cggcgcacgg 29940cgtccgcctg accacccagg gcgaggttac ctgttccctc atccgggagt ttaccctccg 30000tcccctgcta gtggagcggg agcggggtcc ctgtgtccta actatcgcct gcaactgccc 30060taaccctgga ttacatcaag atctttgctg tcatctctgt gctgagttta ataaacgctg 30120agatcagaat ctactggggc tcctgtcgcc atcctgtgaa cgccaccgtc ttcacccacc 30180ccgaccaggc ccaggcgaac ctcacctgcg gtctgcatcg gagggccaag aagtacctca 30240cctggtactt caacggcacc ccctttgtgg tttacaacag cttcgacggg gacggagtct 30300ccctgaaaga ccagctctcc ggtctcagct actccatcca caagaacacc accctccaac 30360tcttccctcc ctacctgccg ggaacctacg agtgcgtcac cggccgctgc acccacctca 30420cccgcctgat cgtaaaccag agctttccgg gaacagataa ctccctcttc cccagaacag 30480gaggtgagct caggaaactc cccggggacc agggcggaga cgtaccttcg acccttgtgg 30540ggttaggatt ttttattacc gggttgctgg ctcttttaat caaagtttcc ttgagatttg 30600ttctttcctt ctacgtgtat gaacacctca acctccaata actctaccct ttcttcggaa 30660tcaggtgact tctctgaaat cgggcttggt gtgctgctta ctctgttgat ttttttcctt 30720atcatactca gccttctgtg cctcaggctc gccgcctgct gcgcacacat ctatatctac 30780tgctggttgc tcaagtgcag gggtcgccac ccaagatgaa caggtacatg gtcctatcga 30840tcctaggcct gctggccctg gcggcctgca gcgccgccaa aaaagagatt acctttgagg 30900agcccgcttg caatgtaact ttcaagcccg agggtgacca atgcaccacc ctcgtcaaat 30960gcgttaccaa tcatgagagg ctgcgcatcg actacaaaaa caaaactggc cagtttgcgg 31020tctatagtgt gtttacgccc ggagacccct ctaactactc tgtcaccgtc ttccagggcg 31080gacagtctaa gatattcaat tacactttcc ctttttatga gttatgcgat gcggtcatgt 31140acatgtcaaa acagtacaac ctgtggcctc cctctcccca ggcgtgtgtg gaaaatactg 31200ggtcttactg ctgtatggct ttcgcaatca ctacgctcgc tctaatctgc acggtgctat 31260acataaaatt caggcagagg cgaatcttta tcgatgaaaa gaaaatgcct tgatcgctaa 31320caccggcttt ctatctgcag aatgaatgca atcacctccc tactaatcac caccaccctc 31380cttgcgattg cccatgggtt gacacgaatc gaagtgccag tggggtccaa tgtcaccatg 31440gtgggccccg ccggcaattc caccctcatg tgggaaaaat ttgtccgcaa tcaatgggtt 31500catttctgct ctaaccgaat cagtatcaag cccagagcca tctgcgatgg gcaaaatcta 31560actctgatca atgtgcaaat gatggatgct gggtactatt acgggcagcg gggagaaatc 31620attaattact ggcgacccca caaggactac atgctgcatg tagtcgaggc acttcccact 31680accaccccca ctaccacctc tcccaccacc accaccacta ctactactac tactactact 31740actactacta ccactaccgc tgcccgccat acccgcaaaa gcaccatgat tagcacaaag 31800ccccctcgtg ctcactccca cgccggcggg cccatcggtg cgacctcaga aaccaccgag 31860ctttgcttct gccaatgcac taacgccagc gctcatgaac tgttcgacct ggagaatgag 31920gatgtccagc agagctccgc ttgcctgacc caggaggctg tggagcccgt tgccctgaag 31980cagatcggtg attcaataat tgactcttct tcttttgcca ctcccgaata ccctcccgat 32040tctactttcc acatcacggg taccaaagac cctaacctct ctttctacct gatgctgctg 32100ctctgtatct ctgtggtctc ttccgcgctg atgttactgg ggatgttctg ctgcctgatc 32160tgccgcagaa agagaaaagc tcgctctcag ggccaaccac tgatgccctt cccctacccc 32220ccggattttg cagataacaa gatatgagct cgctgctgac actaaccgct ttactagcct 32280gcgctctaac ccttgtcgct tgcgactcga gattccacaa tgtcacagct gtggcaggag 32340aaaatgttac tttcaactcc acggccgata cccagtggtc gtggagtggc tcaggtagct 32400acttaactat ctgcaatagc tccacttccc ccggcatatc cccaaccaag taccaatgca 32460atgccagcct gttcaccctc atcaacgctt ccaccctgga caatggactc tatgtaggct 32520atgtaccctt tggtgggcaa ggaaagaccc acgcttacaa cctggaagtt cgccagccca 32580gaaccactac ccaagcttct cccaccacca ccaccaccac caccatcacc agcagcagca 32640gcagcagcag ccacagcagc agcagcagat tattgacttt ggttttggcc agctcatctg 32700ccgctaccca ggccatctac agctctgtgc ccgaaaccac tcagatccac cgcccagaaa 32760cgaccaccgc caccacccta cacacctcca gcgatcagat gccgaccaac atcaccccct 32820tggctcttca aatgggactt acaagcccca ctccaaaacc agtggatgcg gccgaggtct 32880ccgccctcgt caatgactgg gcggggctgg gaatgtggtg gttcgccata ggcatgatgg 32940cgctctgcct gcttctgctc tggctcatct gctgcctcca ccgcaggcga gccagacccc 33000ccatctatag acccatcatt gtcctgaacc ccgataatga tgggatccat agattggatg 33060gcctgaaaaa cctacttttt tcttttacag tatgataaat tgagacatgc ctcgcatttt 33120cttgtacatg ttccttctcc caccttttct ggggtgttct acgctggccg ctgtgtctca 33180cctggaggta gactgcctct cacccttcac tgtctacctg ctttacggat tggtcaccct 33240cactctcatc tgcagcctaa tcacagtaat catcgccttc atccagtgca ttgattacat 33300ctgtgtgcgc ctcgcatact tcagacacca cccgcagtac cgagacagga acattgccca 33360acttctaaga ctgctctaat catgcataag actgtgatct gccttctgat cctctgcatc 33420ctgcccaccc tcacctcctg ccagtacacc acaaaatctc cgcgcaaaag acatgcctcc 33480tgccgcttca cccaactgtg gaatataccc aaatgctaca acgaaaagag cgagctctcc 33540gaagcttggc tgtatggggt catctgtgtc ttagttttct gcagcactgt ctttgccctc 33600ataatctacc cctactttga tttgggatgg aacgcgatcg atgccatgaa ttaccccacc 33660tttcccgcac ccgagataat tccactgcga caagttgtac ccgttgtcgt taatcaacgc 33720cccccatccc ctacgcccac tgaaatcagc tactttaacc taacaggcgg agatgactga 33780cgccctagat ctagaaatgg acggcatcag taccgagcag cgtctcctag agaggcgcag 33840gcaggcggct gagcaagagc gcctcaatca ggagctccga gatctcgtta acctgcacca 33900gtgcaaaaga ggcatctttt gtctggtaaa gcaggccaaa gtcacctacg agaagaccgg 33960caacagccac cgcctcagtt acaaattgcc cacccagcgc cagaagctgg tgctcatggt 34020gggtgagaat cccatcaccg tcacccagca ctcggtagag accgaggggt gtctgcactc 34080cccctgtcgg ggtccagaag acctctgcac cctggtaaag accctgtgcg gtctcagaga 34140tttagtcccc tttaactaat caaacactgg aatcaataaa aagaatcact tacttaaaat 34200cagacagcag gtctctgtcc agtttattca gcagcacctc cttcccctcc tcccaactct 34260ggtactccaa acgccttctg gcggcaaact tcctccacac cctgaaggga atgtcagatt 34320cttgctcctg tccctccgca cccactatct tcatgttgtt gcagatgaag cgcaccaaaa 34380cgtctgacga gagcttcaac cccgtgtacc cctatgacac ggaaagcggc cctccctccg 34440tccctttcct cacccctccc ttcgtgtctc ccgatggatt ccaagaaagt ccccccgggg 34500tcctgtctct gaacctggcc gagcccctgg tcacttccca cggcatgctc gccctgaaaa 34560tgggaagtgg cctctccctg gacgacgctg gcaacctcac ctctcaagat atcaccaccg 34620ctagccctcc cctcaaaaaa accaagacca acctcagcct agaaacctca tcccccctaa 34680ctgtgagcac ctcaggcgcc ctcaccgtag cagccgccgc tcccctggcg gtggccggca 34740cctccctcac catgcaatca gaggcccccc tgacagtaca ggatgcaaaa ctcaccctgg 34800ccaccaaagg ccccctgacc gtgtctgaag gcaaactggc cttgcaaaca tcggccccgc 34860tgacggccgc tgacagcagc accctcacag tcagtgccac accacccctt agcacaagca 34920atggcagctt gggtattgac atgcaagccc ccatttacac caccaatgga aaactaggac 34980ttaactttgg cgctcccctg catgtggtag acagcctaaa tgcactgact gtagttactg 35040gccaaggtct tacgataaac ggaacagccc tacaaactag agtctcaggt gccctcaact 35100atgacacatc aggaaaccta gaattgagag ctgcaggggg tatgcgagtt gatgcaaatg 35160gtcaacttat ccttgatgta gcttacccat ttgatgcaca aaacaatctc agccttaggc 35220ttggacaggg acccctgttt gttaactctg cccacaactt ggatgttaac tacaacagag 35280gcctctacct gttcacatct ggaaatacca aaaagctaga agttaatatc aaaacagcca 35340agggtctcat ttatgatgac actgctatag caatcaatgc gggtgatggg ctacagtttg 35400actcaggctc agatacaaat ccattaaaaa ctaaacttgg attaggactg gattatgact 35460ccagcagagc cataattgct aaactgggaa ctggcctaag ctttgacaac acaggtgcca 35520tcacagtagg caacaaaaat gatgacaagc ttaccttgtg gaccacacca gacccatccc 35580ctaactgtag aatctattca gagaaagatg ctaaattcac acttgttttg actaaatgcg 35640gcagtcaggt gttggccagc gtttctgttt tatctgtaaa aggtagcctt gcgcccatca 35700gtggcacagt aactagtgct cagattgtcc tcagatttga tgaaaatgga gttctactaa 35760gcaattcttc ccttgaccct caatactgga actacagaaa aggtgacctt acagagggca 35820ctgcatatac caacgcagtg ggatttatgc ccaacctcac agcataccca aaaacacaga 35880gccaaactgc taaaagcaac attgtaagtc aggtttactt gaatggggac aaatccaaac 35940ccatgaccct caccattacc ctcaatggaa ctaatgaaac aggagatgcc acagtaagca 36000cttactccat gtcattctca tggaactgga atggaagtaa ttacattaat gaaacgttcc 36060aaaccaactc cttcaccttc tcctacatcg cccaagaata aaaagcatga cgctgttgat 36120ttgattcaat gtgtttctgt tttattttca agcacaacaa aatcattcaa gtcattcttc 36180catcttagct taatagacac agtagcttaa tagacccagt agtgcaaagc cccattctag 36240cttataacta gtggagaagt actcgcctac atgggggtag agtcataatc gtgcatcagg 36300atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg ctccgtcctg 36360caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg cagcataagg 36420cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc acagtaactg 36480cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta tccaaagctc 36540atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta gattaagtgg 36600cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt gtaattcacc 36660acctcccggt accatataaa cctctgatta aacatggcgc catccaccac catcctaaac 36720cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact ggaacaatga 36780cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg 36840gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc ccgcgttaga 36900accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact gcagggaaga 36960cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag cagcggatga 37020tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc cctactgtac 37080ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg 37140gacgtagtca tatttcctga agtcttagat ctctcaacgc agcaccagca ccaacacttc 37200gcagtgtaaa aggccaagtg ccgagagagt atatatagga ataaaaagtg acgtaaacgg 37260gcaaagtcca aaaaacgccc agaaaaaccg cacgcgaacc tacgccccga aacgaaagcc 37320aaaaaacact agacactccc ttccggcgtc aacttccgct ttcccacgct acgtcacttg 37380ccccagtcaa acaaactaca tatcccgaac ttccaagtcg ccacgcccaa aacaccgcct 37440acacctcccc gcccgccggc ccgcccccaa acccgcctcc cgccccgcgc cccgccccgc 37500gccgcccatc tcattatcat attggcttca atccaaaata aggtatatta ttgatgatg 37559121109DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic polynucleotide" 12ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc 60ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca 120ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta 180tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta 240tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat 300cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca tctccccccc 360ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag cgatgggggc 420gggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg 480aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg 540gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg ctccctatca gtgatagaga 600tctccctatc agtgatagag atcgtcgacg agctcgcggc gggcgggagt cgctgcgcgc 660tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg 720accgcgttac taaaacaggt aagtccggcc tccgcgccgg gttttggcgc ctcccgcggg 780cgcccccctc ctcacggcga gcgctgccac gtcagacgaa gggcgcagcg agcgtcctga 840tccttccgcc cggacgctca ggacagcggc ccgctgctca taagactcgg ccttagaacc 900ccagtatcag cagaaggaca ttttaggacg ggacttgggt gactctaggg cactggtttt 960ctttccagag agcggaacag gcgaggaaaa gtagtccctt ctcggcgatt ctgcggaggg 1020atctccgtgg ggcggtgaac gccgatgatg cctctactaa ccatgttcat gttttctttt 1080tttttctaca ggtcctgggt gacgaacag 11091333DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 13atacggacta gtggagaagt actcgcctac atg 331436DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 14atacggaaga tctaagactt caggaaatat gactac 361546DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 15attcagtgta caggcgcgcc aaagcatgac gctgttgatt tgattc 461635DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 16actaggacta gttataagct agaatggggc tttgc 351779DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 17ttaatagaca cagtagctta atagacccag tagtgcaaag ccccattcta gcttataacc 60cctatttgtt tatttttct 791893DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 18atatatactc tctcggcact tggcctttta cactgcgaag tgttggtgct ggtgctgcgt 60tgagagatct ttatttgtta actgttaatt gtc 931923DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 19ttaatagaca cagtagctta ata 232020DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 20ggaagggagt gtctagtgtt 202125DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 21caatgggcgt ggatagcggt ttgac 252219DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 22cagcatgcct gctattgtc 192329DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 23catctacgta ttagtcatcg ctattacca 292421DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic primer" 24gacttggaaa tccccgtgag t 212525DNAArtificial Sequencesource/note="Description of Artificial Sequence Synthetic probe" 25acatcaatgg gcgtggatag cggtt 2526592DNAWoodchuck hepatitis virus 26taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc 60tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg 120tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt 180gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac 240tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc 300tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct 360gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct 420cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct 480caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct 540tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc ct 59227543PRTSimian adenovirus 27Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Ser Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro

20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Ile Thr Thr Ala Ser Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ser Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Ile Asn Val Ser Ser Gly Ser Leu Gly Leu Asp 180 185 190Met Glu Asp Pro Met Tyr Thr His Asp Gly Lys Leu Gly Ile Arg Ile 195 200 205Gly Gly Pro Leu Arg Val Val Asp Ser Leu His Thr Leu Thr Val Val 210 215 220Thr Gly Asn Gly Leu Thr Val Asp Asn Asn Ala Leu Gln Thr Arg Val225 230 235 240Thr Gly Ala Leu Gly Tyr Asp Thr Ser Gly Asn Leu Gln Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Ile Asp Ala Asn Gly Gln Leu Ile Leu Asn Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Tyr Ile Asn Thr Asp His Asn Leu Asp Leu Asn Cys Asn 290 295 300Arg Gly Leu Thr Thr Thr Thr Thr Asn Asn Thr Lys Lys Leu Glu Thr305 310 315 320Lys Ile Ser Ser Gly Leu Asp Tyr Asp Thr Asn Gly Ala Val Ile Ile 325 330 335Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly Ala Leu Thr Val 340 345 350Gly Asn Thr Gly Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro 355 360 365Ser Pro Asn Cys Arg Ile His Ser Asp Lys Asp Cys Lys Phe Thr Leu 370 375 380Val Leu Thr Lys Cys Gly Ser Gln Ile Leu Ala Ser Val Ala Ala Leu385 390 395 400Ala Val Ser Gly Asn Leu Ala Ser Ile Thr Gly Thr Val Ala Ser Val 405 410 415Thr Ile Phe Leu Arg Phe Asp Gln Asn Gly Val Leu Met Glu Asn Ser 420 425 430Ser Leu Asp Arg Gln Tyr Trp Asn Phe Arg Asn Gly Asn Ser Thr Asn 435 440 445Ala Ala Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Ala Ala 450 455 460Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Asn Asn Ile Val Ser Gln465 470 475 480Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr Leu Thr Ile Thr 485 490 495Leu Asn Gly Thr Asn Glu Ser Ser Glu Thr Ser Gln Val Ser His Tyr 500 505 510Ser Met Ser Phe Thr Trp Ala Trp Glu Ser Gly Gln Tyr Ala Thr Glu 515 520 525Thr Phe Ala Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Glu Gln 530 535 54028541PRTSimian adenovirus 28Met Lys Arg Ala Lys Thr Ser Asp Glu Thr Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Arg Leu Ser Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Asn Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Val Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Gln Thr Ser Ala Pro Leu Thr Val Ser Ser Gly Ser Leu 100 105 110Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu Thr 115 120 125Met Gln Ser Gln Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Gly Leu 130 135 140Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Thr Leu Gln145 150 155 160Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val Gly 165 170 175Thr Thr Pro Pro Ile Ser Val Ser Ser Gly Ser Leu Gly Leu Asp Met 180 185 190Glu Asp Pro Met Tyr Thr His Asp Gly Lys Leu Gly Ile Arg Ile Gly 195 200 205Gly Pro Leu Gln Val Val Asp Ser Leu His Thr Leu Thr Val Val Thr 210 215 220Gly Asn Gly Ile Thr Val Ala Asn Asn Ala Leu Gln Thr Lys Val Ala225 230 235 240Gly Ala Leu Gly Tyr Asp Ser Ser Gly Asn Leu Glu Leu Arg Ala Ala 245 250 255Gly Gly Met Arg Ile Asn Thr Gly Gly Gln Leu Ile Leu Asp Val Ala 260 265 270Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln Gly 275 280 285Pro Leu Tyr Val Asn Thr Asn His Asn Leu Asp Leu Asn Cys Asn Arg 290 295 300Gly Leu Thr Thr Thr Thr Ser Ser Asn Thr Thr Lys Leu Glu Thr Lys305 310 315 320Ile Asp Ser Gly Leu Asp Tyr Asn Ala Asn Gly Ala Ile Ile Ala Lys 325 330 335Leu Gly Thr Gly Leu Thr Phe Asp Asn Thr Gly Ala Ile Thr Val Gly 340 345 350Asn Thr Gly Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser 355 360 365Pro Asn Cys Arg Ile His Ala Asp Lys Asp Lys Phe Thr Leu Val Leu 370 375 380Thr Lys Cys Gly Ser Gln Ile Leu Ala Ser Val Ala Ala Leu Ala Val385 390 395 400Ser Gly Asn Leu Ser Ser Met Thr Gly Thr Val Ser Ser Val Thr Ile 405 410 415Phe Leu Arg Phe Asp Gln Asn Gly Val Leu Met Glu Asn Ser Ser Leu 420 425 430Asp Lys Glu Tyr Trp Asn Phe Arg Asn Gly Asn Ser Thr Asn Ala Thr 435 440 445Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Ser Ala Tyr Pro 450 455 460Lys Thr Gln Ser Gln Thr Ala Lys Asn Asn Ile Val Ser Glu Val Tyr465 470 475 480Leu His Gly Asp Lys Ser Lys Pro Met Ile Leu Thr Ile Thr Leu Asn 485 490 495Gly Thr Asn Glu Ser Ser Glu Thr Ser Gln Val Ser His Tyr Ser Met 500 505 510Ser Phe Thr Trp Ser Trp Asp Ser Gly Lys Tyr Ala Thr Glu Thr Phe 515 520 525Ala Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Glu Gln 530 535 54029543PRTSimian adenovirus 29Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Ser Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Ile Thr Ser Thr Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ser Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Ala Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ser Thr Pro Pro Ile Ser Val Ser Ser Gly Ser Leu Gly Leu Asp 180 185 190Met Glu Asp Pro Met Tyr Thr His Asp Gly Lys Leu Gly Ile Arg Ile 195 200 205Gly Gly Pro Leu Arg Val Val Asp Ser Leu His Thr Leu Thr Val Val 210 215 220Thr Gly Asn Gly Leu Thr Val Asp Asn Asn Ala Leu Gln Thr Arg Val225 230 235 240Thr Gly Ala Leu Gly Tyr Asp Thr Ser Gly Asn Leu Gln Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Ile Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Tyr Val Asn Thr Asp His Asn Leu Asp Leu Asn Cys Asn 290 295 300Arg Gly Leu Thr Thr Thr Thr Thr Asn Asn Thr Lys Lys Leu Glu Thr305 310 315 320Lys Ile Ser Ser Gly Leu Asp Tyr Asp Thr Asn Gly Ala Val Ile Ile 325 330 335Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly Ala Leu Thr Val 340 345 350Gly Asn Thr Gly Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro 355 360 365Ser Pro Asn Cys Arg Ile His Ser Asp Lys Asp Cys Lys Phe Thr Leu 370 375 380Val Leu Thr Lys Cys Gly Ser Gln Ile Leu Ala Ser Val Ala Ala Leu385 390 395 400Ala Val Ser Gly Asn Leu Ala Ser Ile Thr Gly Thr Val Ala Ser Val 405 410 415Thr Ile Phe Leu Arg Phe Asp Gln Asn Gly Val Leu Met Glu Asn Ser 420 425 430Ser Leu Asp Lys Gln Tyr Trp Asn Phe Arg Asn Gly Asn Ser Thr Asn 435 440 445Ala Ala Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Ala Ala 450 455 460Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Asn Asn Ile Val Ser Gln465 470 475 480Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr Leu Thr Ile Thr 485 490 495Leu Asn Gly Thr Asn Glu Ser Ser Glu Thr Ser Gln Val Ser His Tyr 500 505 510Ser Met Ser Phe Thr Trp Ala Trp Glu Ser Gly Gln Tyr Ala Thr Glu 515 520 525Thr Phe Ala Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Glu Gln 530 535 54030543PRTSimian adenovirus 30Met Lys Arg Thr Lys Thr Ser Asp Lys Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Thr Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ala Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Leu Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Ile Ser Val Ser Ser Gly Ser Leu Gly Leu Asp 180 185 190Met Glu Asp Pro Met Tyr Thr His Asp Gly Lys Leu Gly Ile Arg Ile 195 200 205Gly Gly Pro Leu Arg Val Val Asp Ser Leu His Thr Leu Thr Val Val 210 215 220Thr Gly Asn Gly Ile Ala Val Asp Asn Asn Ala Leu Gln Thr Arg Val225 230 235 240Thr Gly Ala Leu Gly Tyr Asp Thr Ser Gly Asn Leu Gln Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Ile Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Tyr Val Asn Thr Asp His Asn Leu Asp Leu Asn Cys Asn 290 295 300Arg Gly Leu Thr Thr Thr Thr Thr Asn Asn Thr Lys Lys Leu Glu Thr305 310 315 320Lys Ile Gly Ser Gly Leu Asp Tyr Asp Thr Asn Gly Ala Val Ile Ile 325 330 335Lys Leu Gly Thr Gly Val Ser Phe Asp Ser Thr Gly Ala Leu Ser Val 340 345 350Gly Asn Thr Gly Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro 355 360 365Ser Pro Asn Cys Arg Ile His Ser Asp Lys Asp Cys Lys Phe Thr Leu 370 375 380Val Leu Thr Lys Cys Gly Ser Gln Ile Leu Ala Ser Val Ala Ala Leu385 390 395 400Ala Val Ser Gly Asn Leu Ala Ser Ile Thr Gly Thr Val Ser Ser Val 405 410 415Thr Ile Phe Leu Arg Phe Asp Gln Asn Gly Val Leu Met Glu Asn Ser 420 425 430Ser Leu Asp Lys Gln Tyr Trp Asn Phe Arg Asn Gly Asn Ser Thr Asn 435 440 445Ala Thr Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Ala Ala 450 455 460Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Asn Asn Ile Val Ser Gln465 470 475 480Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr Leu Thr Ile Thr 485 490 495Leu Asn Gly Thr Asn Glu Ser Ser Glu Thr Ser Gln Val Ser His Tyr 500 505 510Ser Met Ser Phe Thr Trp Ala Trp Glu Ser Gly Gln Tyr Ala Thr Glu 515 520 525Thr Phe Ala Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Glu Gln 530 535 54031543PRTSimian adenovirus 31Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Thr Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ala Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Leu Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Ile Asn Val Ser Ser Gly Ser Leu Gly Leu Asp 180 185 190Met Glu Asn Pro Met Tyr Thr His Asp Gly Lys Leu Gly Ile Arg Ile 195 200 205Gly Gly Pro Leu Arg Val Val Asp Ser Leu His Thr Leu Thr Val Val 210 215 220Thr Gly Asn Gly Ile Ala Val Asp Asn Asn Ala Leu Gln Thr Arg Val225 230 235 240Thr Gly Ala Leu Gly Tyr Asp Thr Ser Gly Asn Leu Gln Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Ile Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Tyr Val Asn Thr Asp His Asn Leu Asp Leu Asn Cys Asn 290 295 300Arg Gly Leu Thr Thr Thr Thr Thr Asn Asn Thr Lys Lys Leu Glu Thr305 310 315

320Lys Ile Gly Ser Gly Leu Asp Tyr Asp Thr Asn Gly Ala Val Ile Ile 325 330 335Lys Leu Gly Thr Gly Val Ser Phe Asp Ser Thr Gly Ala Leu Ser Val 340 345 350Gly Asn Thr Gly Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro 355 360 365Ser Pro Asn Cys Arg Ile His Ser Asp Lys Asp Cys Lys Phe Thr Leu 370 375 380Val Leu Thr Lys Cys Gly Ser Gln Ile Leu Ala Ser Val Ala Ala Leu385 390 395 400Ala Val Ser Gly Asn Leu Ala Ser Ile Thr Gly Thr Val Ser Ser Val 405 410 415Thr Ile Phe Leu Arg Phe Asp Gln Asn Gly Val Leu Met Glu Asn Ser 420 425 430Ser Leu Asp Lys Gln Tyr Trp Asn Phe Arg Asn Gly Asn Ser Thr Asn 435 440 445Ala Thr Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Ala Ala 450 455 460Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Asn Asn Ile Val Ser Gln465 470 475 480Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Ile Leu Thr Ile Thr 485 490 495Leu Asn Gly Thr Asn Glu Ser Ser Glu Thr Ser Gln Val Ser His Tyr 500 505 510Ser Met Ser Phe Thr Trp Ala Trp Glu Ser Gly Gln Tyr Ala Thr Glu 515 520 525Thr Phe Ala Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Glu Gln 530 535 54032578PRTSimian adenovirus 32Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Thr Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ala Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Leu Ala Ala Ala Val Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Ile 165 170 175Ser Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Gly Ile Asp 180 185 190Met Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Gly Leu Asn Phe 195 200 205Gly Ala Pro Leu His Val Val Asp Ser Leu Asn Ala Leu Thr Val Val 210 215 220Thr Gly Gln Gly Leu Thr Ile Asn Gly Thr Ala Leu Gln Thr Arg Val225 230 235 240Ser Gly Ala Leu Asn Tyr Asp Ser Ser Gly Asn Leu Glu Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Val Asp Ala Asn Gly Lys Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Phe Val Asn Ser Ala His Asn Leu Asp Val Asn Tyr Asn 290 295 300Arg Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val305 310 315 320Asn Ile Lys Thr Ala Lys Gly Leu Ile Tyr Asp Asp Thr Ala Ile Ala 325 330 335Ile Asn Pro Gly Asp Gly Leu Glu Phe Gly Ser Gly Ser Asp Thr Asn 340 345 350Pro Leu Lys Thr Lys Leu Gly Leu Gly Leu Glu Tyr Asp Ser Ser Arg 355 360 365Ala Ile Ile Ala Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly 370 375 380Ala Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr385 390 395 400Thr Pro Asp Pro Ser Pro Asn Cys Arg Ile Tyr Ser Glu Lys Asp Ala 405 410 415Lys Phe Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser 420 425 430Val Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr 435 440 445Val Thr Ser Ala Gln Ile Ile Leu Arg Phe Asp Glu Asn Gly Val Leu 450 455 460Leu Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly465 470 475 480Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro 485 490 495Asn Leu Thr Ala Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Ser Asn 500 505 510Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Ile 515 520 525Leu Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val 530 535 540Ser Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr545 550 555 560Ile Asn Glu Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala 565 570 575Gln Glu33578PRTSimian adenovirus 33Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Ser Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Ile Thr Thr Ala Ser Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ser Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Gly Ile Asp 180 185 190Met Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Gly Leu Asn Phe 195 200 205Gly Ala Pro Leu His Val Val Asp Ser Leu Asn Ala Leu Thr Val Val 210 215 220Thr Gly Gln Gly Leu Thr Ile Asn Gly Thr Ala Leu Gln Thr Arg Val225 230 235 240Ser Gly Ala Leu Asn Tyr Asp Thr Ser Gly Asn Leu Glu Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Val Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Phe Val Asn Ser Ala His Asn Leu Asp Val Asn Tyr Asn 290 295 300Arg Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val305 310 315 320Asn Ile Lys Thr Ala Lys Gly Leu Ile Tyr Asp Asp Thr Ala Ile Ala 325 330 335Ile Asn Ala Gly Asp Gly Leu Gln Phe Asp Ser Gly Ser Asp Thr Asn 340 345 350Pro Leu Lys Thr Lys Leu Gly Leu Gly Leu Asp Tyr Asp Ser Ser Arg 355 360 365Ala Ile Ile Ala Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly 370 375 380Ala Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr385 390 395 400Thr Pro Asp Pro Ser Pro Asn Cys Arg Ile Tyr Ser Glu Lys Asp Ala 405 410 415Lys Phe Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser 420 425 430Val Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr 435 440 445Val Thr Ser Ala Gln Ile Val Leu Arg Phe Asp Glu Asn Gly Val Leu 450 455 460Leu Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly465 470 475 480Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro 485 490 495Asn Leu Thr Ala Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Ser Asn 500 505 510Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr 515 520 525Leu Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val 530 535 540Ser Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr545 550 555 560Ile Asn Glu Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala 565 570 575Gln Glu34578PRTSimian adenovirus 34Met Lys Arg Thr Lys Thr Ser Asp Glu Ser Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Ser Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Asn Leu Ala Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Ser Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Ile Thr Thr Ala Ser Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Glu Thr Ser Ser Pro Leu Thr Val Ser Thr Ser Gly Ala 100 105 110Leu Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu 115 120 125Thr Met Gln Ser Glu Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Thr 130 135 140Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu145 150 155 160Gln Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val 165 170 175Ser Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Gly Ile Asp 180 185 190Met Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Gly Leu Asn Phe 195 200 205Gly Ala Pro Leu His Val Val Asp Ser Leu Asn Ala Leu Thr Val Val 210 215 220Thr Gly Gln Gly Leu Thr Ile Asn Gly Thr Ala Leu Gln Thr Arg Val225 230 235 240Ser Gly Ala Leu Asn Tyr Asp Thr Ser Gly Asn Leu Glu Leu Arg Ala 245 250 255Ala Gly Gly Met Arg Val Asp Ala Asn Gly Gln Leu Ile Leu Asp Val 260 265 270Ala Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln 275 280 285Gly Pro Leu Phe Val Asn Ser Ala His Asn Leu Asp Val Asn Tyr Asn 290 295 300Arg Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val305 310 315 320Asn Ile Lys Thr Ala Lys Gly Leu Ile Tyr Asp Asp Thr Ala Ile Ala 325 330 335Ile Asn Ala Gly Asp Gly Leu Gln Phe Asp Ser Gly Ser Asp Thr Asn 340 345 350Pro Leu Lys Thr Lys Leu Gly Leu Gly Leu Asp Tyr Asp Ser Ser Arg 355 360 365Ala Ile Ile Ala Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly 370 375 380Ala Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr385 390 395 400Thr Pro Asp Pro Ser Pro Asn Cys Arg Ile Tyr Ser Glu Lys Asp Ala 405 410 415Lys Phe Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser 420 425 430Val Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr 435 440 445Val Thr Ser Ala Gln Ile Val Leu Arg Phe Asp Glu Asn Gly Val Leu 450 455 460Leu Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly465 470 475 480Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro 485 490 495Asn Leu Thr Ala Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Ser Asn 500 505 510Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Ser Lys Pro Met Thr 515 520 525Leu Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val 530 535 540Ser Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr545 550 555 560Ile Asn Glu Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala 565 570 575Gln Glu35577PRTSimian adenovirus 35Met Lys Arg Ala Lys Thr Ser Asp Glu Thr Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Arg Leu Ser Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Asn Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Val Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Gln Thr Ser Ala Pro Leu Thr Val Ser Ser Gly Ser Leu 100 105 110Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu Thr 115 120 125Met Gln Ser Gln Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Gly Leu 130 135 140Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Thr Leu Gln145 150 155 160Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val Ser 165 170 175Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Ser Ile Asp Met 180 185 190Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Ala Leu Asn Ile Gly 195 200 205Ala Pro Leu His Val Val Asp Thr Leu Asn Ala Leu Thr Val Val Thr 210 215 220Gly Gln Gly Leu Thr Ile Asn Gly Arg Ala Leu Gln Thr Arg Val Thr225 230 235 240Gly Ala Leu Ser Tyr Asp Thr Glu Gly Asn Ile Gln Leu Gln Ala Gly 245 250 255Gly Gly Met Arg Ile Asp Asn Asn Gly Gln Leu Ile Leu Asn Val Ala 260 265 270Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln Gly 275 280 285Pro Leu Ile Val Asn Ser Ala His Asn Leu Asp Leu Asn Leu Asn Arg 290 295 300Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val Asn305 310 315 320Ile Lys Thr Ala Lys Gly Leu Phe Tyr Asp Gly Thr Ala Ile Ala Ile 325 330 335Asn Ala Gly Asp Gly Leu Gln Phe Gly Ser Gly Ser Asp Thr Asn Pro 340 345 350Leu Gln Thr Lys Leu Gly Leu Gly Leu Glu Tyr Asp Ser Asn Lys Ala 355 360 365Ile Ile Thr Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly Ala 370 375 380Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr Thr385 390 395 400Pro Asp Pro Ser Pro Asn Cys Arg Ile Asn Ser Glu Lys Asp Ala Lys 405 410 415Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser Val 420 425 430Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr Val 435 440 445Thr Ser Ala Gln Ile Val Leu Arg Phe Asp Glu Asn Gly Val Leu Leu 450 455 460Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly Asp465 470 475 480Ser Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro Asn 485 490 495Leu Thr Ala Tyr Pro Lys Thr

Gln Ser Gln Thr Ala Lys Ser Asn Ile 500 505 510Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr Lys Pro Met Thr Leu 515 520 525Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val Ser 530 535 540Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr Ile545 550 555 560Asn Asp Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Gln 565 570 575Glu36577PRTSimian adenovirus 36Met Lys Arg Ala Lys Thr Ser Asp Glu Thr Phe Asn Pro Val Tyr Pro1 5 10 15Tyr Asp Thr Glu Asn Gly Pro Pro Ser Val Pro Phe Leu Thr Pro Pro 20 25 30Phe Val Ser Pro Asp Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45Leu Arg Leu Ser Glu Pro Leu Val Thr Ser His Gly Met Leu Ala Leu 50 55 60Lys Met Gly Asn Gly Leu Ser Leu Asp Asp Ala Gly Asn Leu Thr Ser65 70 75 80Gln Asp Val Thr Thr Val Thr Pro Pro Leu Lys Lys Thr Lys Thr Asn 85 90 95Leu Ser Leu Gln Thr Ser Ala Pro Leu Thr Val Ser Ser Gly Ser Leu 100 105 110Thr Val Ala Ala Ala Ala Pro Leu Ala Val Ala Gly Thr Ser Leu Thr 115 120 125Met Gln Ser Gln Ala Pro Leu Thr Val Gln Asp Ala Lys Leu Gly Leu 130 135 140Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Thr Leu Gln145 150 155 160Thr Ser Ala Pro Leu Thr Ala Ala Asp Ser Ser Thr Leu Thr Val Ser 165 170 175Ala Thr Pro Pro Leu Ser Thr Ser Asn Gly Ser Leu Ser Ile Asp Met 180 185 190Gln Ala Pro Ile Tyr Thr Thr Asn Gly Lys Leu Ala Leu Asn Ile Gly 195 200 205Ala Pro Leu His Val Val Asp Thr Leu Asn Ala Leu Thr Val Val Thr 210 215 220Gly Gln Gly Leu Thr Ile Asn Gly Arg Ala Leu Gln Thr Arg Val Thr225 230 235 240Gly Ala Leu Ser Tyr Asp Thr Glu Gly Asn Ile Gln Leu Gln Ala Gly 245 250 255Gly Gly Met Arg Ile Asp Asn Asn Gly Gln Leu Ile Leu Asn Val Ala 260 265 270Tyr Pro Phe Asp Ala Gln Asn Asn Leu Ser Leu Arg Leu Gly Gln Gly 275 280 285Pro Leu Ile Val Asn Ser Ala His Asn Leu Asp Leu Asn Leu Asn Arg 290 295 300Gly Leu Tyr Leu Phe Thr Ser Gly Asn Thr Lys Lys Leu Glu Val Asn305 310 315 320Ile Lys Thr Ala Lys Gly Leu Phe Tyr Asp Gly Thr Ala Ile Ala Ile 325 330 335Asn Ala Gly Asp Gly Leu Gln Phe Gly Ser Gly Ser Asp Thr Asn Pro 340 345 350Leu Gln Thr Lys Leu Gly Leu Gly Leu Glu Tyr Asp Ser Asn Lys Ala 355 360 365Ile Ile Thr Lys Leu Gly Thr Gly Leu Ser Phe Asp Asn Thr Gly Ala 370 375 380Ile Thr Val Gly Asn Lys Asn Asp Asp Lys Leu Thr Leu Trp Thr Thr385 390 395 400Pro Asp Pro Ser Pro Asn Cys Arg Ile Asn Ser Glu Lys Asp Ala Lys 405 410 415Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Val Leu Ala Ser Val 420 425 430Ser Val Leu Ser Val Lys Gly Ser Leu Ala Pro Ile Ser Gly Thr Val 435 440 445Thr Ser Ala Gln Ile Val Leu Arg Phe Asp Glu Asn Gly Val Leu Leu 450 455 460Ser Asn Ser Ser Leu Asp Pro Gln Tyr Trp Asn Tyr Arg Lys Gly Asp465 470 475 480Ser Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly Phe Met Pro Asn 485 490 495Leu Thr Ala Tyr Pro Lys Thr Gln Ser Gln Thr Ala Lys Ser Asn Ile 500 505 510Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr Lys Pro Met Thr Leu 515 520 525Thr Ile Thr Leu Asn Gly Thr Asn Glu Thr Gly Asp Ala Thr Val Ser 530 535 540Thr Tyr Ser Met Ser Phe Ser Trp Asn Trp Asn Gly Ser Asn Tyr Ile545 550 555 560Asn Asp Thr Phe Gln Thr Asn Ser Phe Thr Phe Ser Tyr Ile Ala Gln 565 570 575Glu371145PRTRespiratory syncytial virus 37Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr1 5 10 15Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 20 25 30Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 35 40 45Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 50 55 60Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys65 70 75 80Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 85 90 95Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 100 105 110Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 115 120 125Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 130 135 140Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu145 150 155 160Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 165 170 175Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 180 185 190Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 195 200 205Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 210 215 220Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn225 230 235 240Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 245 250 255Leu Leu Ser Leu Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu 260 265 270Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met 275 280 285Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu 290 295 300Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu305 310 315 320Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr 325 330 335Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro 340 345 350Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr 355 360 365Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp 370 375 380Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp385 390 395 400Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr 405 410 415Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys 420 425 430Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr 435 440 445Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys 450 455 460Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu465 470 475 480Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 485 490 495Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 500 505 510His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Arg Lys Arg Arg Ala 515 520 525Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp 530 535 540Val Glu Ser Asn Pro Gly Pro Met Ala Leu Ser Lys Val Lys Leu Asn545 550 555 560Asp Thr Leu Asn Lys Asp Gln Leu Leu Ser Ser Ser Lys Tyr Thr Ile 565 570 575Gln Arg Ser Thr Gly Asp Ser Ile Asp Thr Pro Asn Tyr Asp Val Gln 580 585 590Lys His Ile Asn Lys Leu Cys Gly Met Leu Leu Ile Thr Glu Asp Ala 595 600 605Asn His Lys Phe Thr Gly Leu Ile Gly Met Leu Tyr Ala Met Ser Arg 610 615 620Leu Gly Arg Glu Asp Thr Ile Lys Ile Leu Arg Asp Ala Gly Tyr His625 630 635 640Val Lys Ala Asn Gly Val Asp Val Thr Thr His Arg Gln Asp Ile Asn 645 650 655Gly Lys Glu Met Lys Phe Glu Val Leu Thr Leu Ala Ser Leu Thr Thr 660 665 670Glu Ile Gln Ile Asn Ile Glu Ile Glu Ser Arg Lys Ser Tyr Lys Lys 675 680 685Met Leu Lys Glu Met Gly Glu Val Ala Pro Glu Tyr Arg His Asp Ser 690 695 700Pro Asp Cys Gly Met Ile Ile Leu Cys Ile Ala Ala Leu Val Ile Thr705 710 715 720Lys Leu Ala Ala Gly Asp Arg Ser Gly Leu Thr Ala Val Ile Arg Arg 725 730 735Ala Asn Asn Val Leu Lys Asn Glu Met Lys Arg Tyr Lys Gly Leu Leu 740 745 750Pro Lys Asp Ile Ala Asn Ser Phe Tyr Glu Val Phe Glu Lys Tyr Pro 755 760 765His Phe Ile Asp Val Phe Val His Phe Gly Ile Ala Gln Ser Ser Thr 770 775 780Arg Gly Gly Ser Arg Val Glu Gly Ile Phe Ala Gly Leu Phe Met Asn785 790 795 800Ala Tyr Gly Ala Gly Gln Val Met Leu Arg Trp Gly Val Leu Ala Lys 805 810 815Ser Val Lys Asn Ile Met Leu Gly His Ala Ser Val Gln Ala Glu Met 820 825 830Glu Gln Val Val Glu Val Tyr Glu Tyr Ala Gln Lys Leu Gly Gly Glu 835 840 845Ala Gly Phe Tyr His Ile Leu Asn Asn Pro Lys Ala Ser Leu Leu Ser 850 855 860Leu Thr Gln Phe Pro His Phe Ser Ser Val Val Leu Gly Asn Ala Ala865 870 875 880Gly Leu Gly Ile Met Gly Glu Tyr Arg Gly Thr Pro Arg Asn Gln Asp 885 890 895Leu Tyr Asp Ala Ala Lys Ala Tyr Ala Glu Gln Leu Lys Glu Asn Gly 900 905 910Val Ile Asn Tyr Ser Val Leu Asp Leu Thr Ala Glu Glu Leu Glu Ala 915 920 925Ile Lys His Gln Leu Asn Pro Lys Asp Asn Asp Val Glu Leu Gly Gly 930 935 940Gly Gly Ser Gly Gly Gly Gly Met Ser Arg Arg Asn Pro Cys Lys Phe945 950 955 960Glu Ile Arg Gly His Cys Leu Asn Gly Lys Arg Cys His Phe Ser His 965 970 975Asn Tyr Phe Glu Trp Pro Pro His Ala Leu Leu Val Arg Gln Asn Phe 980 985 990Met Leu Asn Arg Ile Leu Lys Ser Met Asp Lys Ser Ile Asp Thr Leu 995 1000 1005Ser Glu Ile Ser Gly Ala Ala Glu Leu Asp Arg Thr Glu Glu Tyr 1010 1015 1020Ala Leu Gly Val Val Gly Val Leu Glu Ser Tyr Ile Gly Ser Ile 1025 1030 1035Asn Asn Ile Thr Lys Gln Ser Ala Cys Val Ala Met Ser Lys Leu 1040 1045 1050Leu Thr Glu Leu Asn Ser Asp Asp Ile Lys Lys Leu Arg Asp Asn 1055 1060 1065Glu Glu Leu Asn Ser Pro Lys Ile Arg Val Tyr Asn Thr Val Ile 1070 1075 1080Ser Tyr Ile Glu Ser Asn Arg Lys Asn Asn Lys Gln Thr Ile His 1085 1090 1095Leu Leu Lys Arg Leu Pro Ala Asp Val Leu Lys Lys Thr Ile Lys 1100 1105 1110Asn Thr Leu Asp Ile His Lys Ser Ile Thr Ile Asn Asn Pro Lys 1115 1120 1125Glu Ser Thr Val Ser Asp Thr Asn Asp His Ala Lys Asn Asn Asp 1130 1135 1140Thr Thr 1145381502DNAHuman immunodeficiency virus 38atgggtgcta gggcttctgt gctgtctggt ggtgagctgg acaagtggga gaagatcagg 60ctgaggcctg gtggcaagaa gaagtacaag ctaaagcaca ttgtgtgggc ctccagggag 120ctggagaggt ttgctgtgaa ccctggcctg ctggagacct ctgaggggtg caggcagatc 180ctgggccagc tccagccctc cctgcaaaca ggctctgagg agctgaggtc cctgtacaac 240acagtggcta ccctgtactg tgtgcaccag aagattgatg tgaaggacac caaggaggcc 300ctggagaaga ttgaggagga gcagaacaag tccaagaaga aggcccagca ggctgctgct 360ggcacaggca actccagcca ggtgtcccag aactacccca ttgtgcagaa cctccagggc 420cagatggtgc accaggccat ctccccccgg accctgaatg cctgggtgaa ggtggtggag 480gagaggcctt ctcccctgag gtgatcccca tgttctctgc cctgtctgag ggtgccaccc 540cccaggacct gaacaccatg ctgaacacag tggggggcca tcaggctgcc atgcagatgc 600tgaaggagac catcaatgag gaggctgctg agtgggacag gctgcatcct gtgcacgctg 660gccccattgc ccccggccag atgagggagc ccaggggctc tgacattgct ggcaccacct 720ccaccctcca ggagcagatt ggctggatga ccaacaaccc ccccatccct gtgggggaaa 780tctacaagag gtggatcatc ctgggcctga acaagattgt gaggatgtac tcccccacct 840ccatcctgga catcaggcag ggccccaagg agcccttcag ggactatgtg gacaggttct 900acaagaccct gagggctgag caggcctccc aggaggtgaa gaactggatg acagagaccc 960tgctggtgca gaatgccaac cctgactgca agaccatcct gaaggccctg ggccctgctg 1020ccaccctgga ggagatgatg acagcctgcc agggggtggg gggccctggt cacaaggcca 1080gggtgctggc tgaggccatg tcccaggtga ccaactccgc caccatcatg atgcagaggg 1140gcaacttcag gaaccagagg aagacagtga agtgcttcaa ctgtggcaag gtgggccaca 1200ttgccaagaa ctgtagggcc cccaggaaga agggctgctg gaagtgtggc aaggagggcc 1260accagatgaa ggactgcaat gagaggcagg ccaacttcct gggcaaaatc tggccctccc 1320acaagggcag gcctggcaac ttcctccagt ccaggcctga gcccacagcc cctcccgagg 1380agtccttcag gtttggggag gagaagacca cccccagcca gaagcaggag cccattgaca 1440aggagctgta ccccctggcc tccctgaggt ccctgtttgg caacgacccc tcctcccagt 1500aa 1502

Claims

1-42. (canceled)

43. A recombinant chimpanzee adenovirus ChAd155 comprising a nucleic acid sequence encoding a heterologous protein wherein: (a) the E1 and E4 regions of chimpanzee adenovirus ChAd155 are deleted; (b) E4orf6 of human adenovirus Ad5 is inserted; (c) the nucleic acid sequence is operatively linked to one or more sequences which direct expression of said heterologous protein in a host cell; and (d) the heterologous protein is an antigenic protein or fragment thereof derived from a virus and is selected from fusion protein (F), the attachment protein (G), the matrix protein (M2), and the nucleoprotein (N) of respiratory syncytial virus (RSV).

44. A composition comprising the recombinant chimpanzee adenovirus ChAd155 vector according to claim 43, and a pharmaceutically acceptable excipient.

45. The recombinant chimpanzee adenovirus ChAd155 according to claim 43, wherein the nucleic acid sequence encoding a heterologous protein encodes an RSV F.DELTA.TM antigen, an RSV M2-1 antigen and an N antigen.

46. The recombinant chimpanzee adenovirus ChAd155 according to claim 43, wherein the nucleic acid sequence encoding a heterologous protein encodes a sequence according to SEQ ID NO: 37.

47. The recombinant chimpanzee adenovirus ChAd155 according to claim 43, wherein the recombinant adenovirus is replication-incompetent.

48. The recombinant chimpanzee adenovirus ChAd155 according to claim 43, wherein the adenovirus is capable of infecting a mammalian cell.

49. The composition according to claim 44, further comprising at least one adjuvant selected from inorganic adjuvants, organic adjuvants, oil-based adjuvants, cytokines, particulate adjuvants, virosomes, bacterial adjuvants, synthetic adjuvants, synthetic polynucleotides adjuvants, and immunostimulatory oligonucleotides containing unmethylated CpG dinucleotides ("CpG").

50. The composition according to claim 49, wherein the adjuvant is a 3D-MPL, QS21, or a mixture thereof.

51. A method of treatment or prophylaxis of respiratory syncytial virus (RSV) infection comprising administering to a patient in need thereof the recombinant chimpanzee vector ChAd155, of claim 43.

52. A method of treatment or prophylaxis of respiratory syncytial virus (RSV) infection comprising administering to a patient in need thereof the composition of claim 44.

53. An isolated polynucleotide comprising the sequence of SEQ ID NO: 11.