BACTERIOPHAGE COMPOSITIONS FOR TREATING STAPHYLOCOCCUS INFECTION

Abstract

The present disclosure relates to bacteriophages and compositions capable of infecting and killing Staphylococcus, and use of the same for treating Staphylococcus, e.g. Staphylococcus aureus, bacterial infections.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 62/978,006, filed Feb. 18, 2020, which is incorporated herein by reference in its entirety and for all purposes.

SEQUENCE LISTING

[0002] The instant application contains a Sequence Listing, which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 18, 2020 is named 054249-519P01US_SEQUENCE_LISTING_ST25.txt and is 377,606 bytes in size.

BACKGROUND

[0003] There is an increasing demand for alternative antibiotics as the number of bacterial strains resistant to traditional, small molecule antibiotic treatment regimens are becoming more numerous. Bacteriophage therapy uses bacterial viruses, or phages, to target and destroy bacteria at various sites of infection. Recent advances in biotechnology have allowed for the fast expansion of naturally existing phage libraries in order to generate potent and specific bacteriophages that can target and destroy a bacterium of interest. Antibiotic-resistant Staphylococcus aureus (SA) is typically found in hospitals and in areas where immune-compromised patients reside. Secondary SA infection is a potentially lethal infection (>20%) that is a common threat to these patients. Indeed, there are approximately 50/100,000 population SA bacteremia cases diagnosed each year in the US alone. Bacteriophage treatment approaches that can circumvent traditional mechanisms of antibiotic resistance, avoid the toxic side effects of traditional small molecule therapies, can be effective against biofilms, and avoid disruption of the native gut flora are especially attractive.

[0004] Thus, there is a large unmet need for a more efficient, potent, and specific anti-SA therapy to replace or augment the traditional small molecule antibiotics currently used to treat SA infections today.

SUMMARY

[0005] Described herein are bacteriophages, compositions of bacteriophages, and use of the same for medical and non-medical applications.

[0006] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 1.

[0007] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1. In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1.

[0008] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 2.

[0009] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0010] In an aspect, provided herein are bacteriophage compositions that include one or more bacteriophages selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In an aspect, provided herein are bacteriophage compositions that include one or more bacteriophages selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0011] In an aspect, provided herein are uses of a composition including one or more distinct bacteriophages that target Staphylococcus aureus in the treatment of subject with a Staphylococcus aureus bacterial infection. The uses include administering the composition to a subject; where at least one of the one or more bacteriophages is selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, at least one of the one or more bacteriophages is selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0012] In an aspect, provided herein is a bacterial host manufacturing strain including a bacteriophage where the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0013] In an aspect, provided herein are methods of treating a subject with a bacterial infection including selecting a bacteriophage based upon resistance to blood complement inactivation and administering the bacteriophage to the subject.

[0014] In an aspect, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophages selected from a bacteriophage including a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the methods of treatment include administering to the subject one or more distinct bacteriophages selected from a bacteriophage including a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0015] In an aspect, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus bacteria, where the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Embodiments will now be described, by way of example only, with reference to the accompanying drawings, in which:

[0017] FIG. 1 shows efficiency of plating and plaque morphology. Equal titers of phage were serially diluted and 2 .mu.L were plated on a lawn of S. aureus. Phage potency was assessed by plaques clarity and efficiency of plating.

[0018] FIG. 2 shows compstatin effect on Sa87 activity after exposure to plasma. Sa87 was exposed to fresh plasma isolated from three donors, in the presence or absence of complement inhibitor compstatin, for 60 minutes; phage were titered using the double-layer agar method. D indicates donor.

[0019] FIG. 3 shows lead phage activity after exposure to plasma. Lead phage candidates were diluted in fresh plasma from six donors and the infectivity was monitored for 90 minutes.

[0020] FIG. 4 shows AP-SA02 markedly reduces SA biofilm mass. Biofilms were treated with AP-SA02 (10.sup.7 phage/well of a 96 well plate) for 5 hours and the percentage of biofilm that was eradicated calculated is reported as percent relative to the same strain treated with vehicle. NRS100 is the negative control.

[0021] FIGS. 5A-5B show AP-SA02 activity in the presence of vancomycin. FIG. 5A shows bacterial growth measured by turbidity (absorbance at 600 nm) in the presence of AP-SA02 and vancomycin in a checkerboard assay. Grey boxes indicate lines on graph depicted in FIG. 5B. AP-SA02 is active against a VRSA strain. Vancomycin, 16 .mu.g/mL; AP-SA02, 0.1 pg/mL.

[0022] FIGS. 6A-6B show the synergistic activity of vancomycin and AP-SA02. FIG. 6A is data showing bacterial growth measured by turbidity (absorbance at 600 nm) in the presence of AP-SA02 and vancomycin in a checkerboard assay. Grey boxes show lines on graph depicted in FIG. 6B. AP-SA02 and vancomycin show synergistic activity against a VRSA strain. Vancomycin, 2 .mu.g/mL.

DETAILED DESCRIPTION

[0023] It is to be understood that the present disclosure is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present disclosure will be limited only by the appended claims.

[0024] The detailed description of the present disclosure is divided into various sections only for the reader's convenience and disclosure found in any section may be combined with that in another section. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present disclosure belongs.

Definitions

[0025] It must be noted that as used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "a bacteriophage composition" includes a plurality of such candidate agents and reference to "the bacteriophage" includes reference to one or more bacteriophages and equivalents thereof known to those skilled in the art, and so forth.

[0026] The term "consists essentially of" as used herein means that only the bacteriophage(s) explicitly indicated are present in the bacteriophage composition, but that said composition may also contain a further non-bacteriophage constituent, such as a pharmaceutically appropriate carrier, diluent, excipient, antibiotic (e.g., chemical antibiotic), etc., or combinations thereof.

[0027] As used herein, the term "about" when used before a numerical designation, e.g., temperature, time, amount, concentration, and such other, including a range, indicates approximations which may vary by (+) or (-) 10%, 5%, or 1%.

[0028] When a range (e.g., dosage range) is listed herein, it is to be understood that the value may include any individual value or range within the recited range(s), including endpoints.

[0029] As used herein, the term "mutant" refers to a bacteriophage differing genetically from ARSA0001 or ARSA0002 but still retaining the ability to infect and kill Staphylococcus aureus target bacteria. Mutants typically comprise bacteriophages with, e.g., silent mutations, conservative mutations, minor deletions, and/or minor replications of genetic material, and retain phenotypic characteristics of the reference bacteriophage. In an embodiment, the mutants retain any observable characteristic or property that is dependent upon the genome of the bacteriophage as described herein, i.e. phenotypic characteristics of said bacteriophage and/or lytic activity against Staphylococcus species. Preferred mutants retain the ability to infect and kill Staphylococcus aureus target bacteria and have less than 10% nucleic acid variation as compared to the genome of the reference bacteriophage, even more preferably less than 7%, more preferably less than 1%. Alternatively, or in combination, mutants have preferably less than 7% amino acid variation in a coded polypeptide sequence as compared to a polypeptide of the reference bacteriophage.

[0030] As used herein, the terms "% identity", "% sequence identity" and "percent identity" in relation to nucleic acid or amino acid sequences designates the level of identity or homology between said sequences and may be determined by techniques known in the art. Any of a variety of sequence alignment methods can be used to determine percent identity, including, without limitation, global methods, local methods and hybrid methods, such as segment approach methods. Protocols to determine percent identity are routine procedures within the scope of one skilled in the art. Global methods align sequences from the beginning to the end of the molecule and determine the best alignment by adding up scores of individual nucleotide pairs and by imposing gap penalties. Non-limiting methods include, e.g., CLUSTAL W, see, e.g., Julie D. Thompson et al., CLUSTAL W: Improving the Sensitivity of Progressive Multiple Sequence Alignment Through Sequence Weighting, Position-Specific Gap Penalties and Weight Matrix Choice, 22(22) Nucleic Acids Research 4673-4680 (1994); and iterative refinement. Non-limiting methods include, e.g., BLAST, Match-box, see, e.g., Align-M, see, e.g., Ivo Van Walle et al., Align-M--A New Algorithm for Multiple Alignment of Highly Divergent Sequences, Bioinformatics 20(9):1428-1435 (2004). This definition also refers to, or may be applied to, the compliment of a test sequence. The definition also includes sequences that have deletions and/or additions, as well as those that have substitutions. As described below, the preferred algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 100 nucleotides in length, or more preferably over a region that is 100-1000 or more nucleotides in length.

[0031] As used herein, the term "bacterial complementation" refers to the ability of a bacteriophage with a particular genome to compensate for a different, distinct bacteriophage with a different genome. More specifically, bacteriophage insensitive mutant colonies (of target bacteria) may arise to a particular bacteriophage but may still be sensitive to a different bacteriophage. In other words, bacteriophage resistant mutant bacteria arising to one phage are still sensitive to another phage.

[0032] As used herein, the term "generalized transduction" refers to a process by which any bacterial DNA may be transferred to another bacterium via a bacteriophage. It is a rare event; a very small percentage of phage particles happen to carry a donor bacterium's DNA, on the order of 1 phage in 10,000. In essence, this is the packaging of bacterial DNA into a viral envelope.

[0033] As used herein, the term "treat" or "treating" is intended to encompass prophylactic treatment as well as corrective treatment (treatment of a subject already suffering from a disease). This may include the medical management of a subject with the intent to cure, ameliorate, stabilize, or prevent a disease, pathological condition, or disorder. This term includes active treatment, that is, treatment directed specifically toward the improvement of a disease, pathological condition, or disorder; and also includes causal treatment, that is, treatment directed toward removal of the cause of the associated disease, pathological condition, or disorder. In addition, this term includes palliative treatment, that is, treatment designed for the relief of symptoms rather than the curing of the disease, pathological condition, or disorder; preventative treatment, that is, treatment directed to minimizing or partially or completely inhibiting the development of the associated disease, pathological condition, or disorder; and supportive treatment, that is, treatment employed to supplement another specific therapy directed toward the improvement of the associated disease, pathological condition, or disorder. It is understood that treatment, while intended to cure, ameliorate, stabilize, or prevent a disease, pathological condition, or disorder, need not actually result in the cure, amelioration, stabilization, or prevention. The effects of treatment can be measured or assessed as described herein and as known in the art as is suitable for the disease, pathological condition, or disorder involved. Such measurements and assessments can be made in qualitative and/or quantitative terms. Thus, for example, characteristics or features of a disease, pathological condition, or disorder and/or symptoms of a disease, pathological condition, or disorder can be reduced to any effect or to any amount.

[0034] As used herein, the term "lytic" or "lytic activity" designates the property of a bacteriophage to cause lysis of a bacterial cell. The lytic activity of a bacteriophage can be tested on a bacterium (e.g., S. aureus strains) according to techniques known in the art. The lytic cycle is named for the process that occurs when a phage has infected a cell, replicated new phage particles, and bursts through the host cell membrane. Some phage exhibit a lysogenic cycle during which the bacteriophage DNA remains practically dormant due to active repression of bacteriophage processes. Whenever the bacteria divides, the DNA of the phage is copied as well. In this way, the virus can continue replicating within its host without lysing the host. At a certain point, conditions may change and the phage enters a lytic cycle. "Obligately lytic" refers to phage that are unable to undergo a lysogenic cycle.

[0035] As used herein, the term "complement system" or "blood complement system" refers the part of the innate immune system that triggers phagocytosis, inflammation, and membrane disruption of foreign bodies, including bacteriophages. The complement systems consists of a classical pathway, an alternative pathway, and a lectin pathway. The classical pathway initiates when a multi-protein complex called C1 is formed upon antigen recognition by IgG or IgM. C1 multi-protein complex is composed of one molecule of C1q, two molecules of C1r, and two molecules of C1s. After undergoing several internal proteolysis steps, the subunits C4 and C2 are generated, and further processed to form C2a, C2b, C4a, and C4b. C2b and C4b combine to form classical-form C3-convertase. C3 is further processed to form C3a and C3b. C3b can then join C3 to form a C5-convertase. Low levels of C3 can be converted to C3b without the presence of an antigen, and can combine with other proteases to form alternative complexes in the alternative complement pathway. The lectin pathway replaces the C1q protein from C1 with lectin-binding proteins, including mannose binding lectin (MBL).

[0036] As used herein, the term "C3" or "complement component C3" refers to any of the proteins involved in the complement pathways: classical, alternative, or lectin. One form of activated C3 is a heterodimer of activated C2 and C4 proteins, C4b2a, also known as C3-convertase. One form activated C3 is a heterodimer of activated C3b and activated factor B, Bb, to form C3bBb.

[0037] As used herein, the term "bacteriophage target" refers to any bacteria species that can be infected by a particular bacteriophage. A bacteriophage recognizes the target bacterial cell surface, binds, and injects its genetic material inside the bacterial host. The genetic material from the infecting phage can be incorporated into the bacterial genome. The bacteriophage may become lysogenic, where the viral genome remains dormant in the bacterial host genome until a triggering event. The bacteriophage may also become lytic, wherein many copies of the infecting phage are produced by the machinery of the infected bacteria, and the copies are subsequently released by bacterial lysis, extrusion, or by budding.

[0038] As used herein, the term "bacterial host manufacturing strain" or "manufacturing strain" refers to the bacteria used to grow bacteriophage. A method for bacteriophage production may require a production process involving at least two operating units, growth of the host bacteria and bacteriophage propagation (or infection). It is important to consider basic parameters for bacterial growth and phage infection, such as the selected substrates for the bacterium and the optimal temperature, both for bacterial growth and phage infection, since these factors may influence the infectivity of phages.

[0039] As used herein, the term "bacteremia" refers to the presence of bacteria in the bloodstream. Bacteria may be introduced into the bloodstream by ordinary activities including brushing teeth, or may be introduced by surgical procedures, implantation of temporary medical devices, urinary tract infections, at the site of a severe injury, or at the site of long-term device implantation.

[0040] As used herein, the term "septicemia" refers to a bacterial infection elsewhere in the body which enters the bloodstream; also known as blood poisoning by bacteria.

[0041] As used herein, the term "Silviavirus" refers to a virus that belongs to Regum: virus, Group 1: dsDNA, Ordo: Caudovirales, Familia: Herelleviridae, Subfamilia: Twortvirinae, Genus: Silviavirus. Species of Genus Silviavirus include, without limitation, Staphylococcus virus Remus, Staphylococcus virus SA11, Staphylococcus virus Romulus, Staphylococcus virus Qdsa001, Staphylococcus virus MR003, Staphylococcus virus StAP1, and Staphylococcus virus Stsau2.

[0042] A use or method typically comprises administering a bacteriophage or bacteriophage composition described herein to a subject. As used herein, a "subject" is a mammal, such as a human or other animal. Preferably, the subject is a human.

[0043] The term "in need of treatment" as used herein refers to a judgment made by a caregiver (e.g., physician, nurse, nurse practitioner, or individual in the case of humans; veterinarian in the case of animals, including non-human mammals) that a subject requires or will benefit from treatment. This judgment is made based on a variety of factors that are in the realm of a caregiver's expertise, but that include the knowledge that the subject is ill, or will be ill, as the result of a condition that is treatable by the compositions of the invention.

[0044] As used herein, the term "isolated" indicates that the bacteriophage are removed from its original environment in which it naturally occurs. In particular, an isolated bacteriophage is, e.g., cultivated, cultured separately from the environment in which it is naturally located.

[0045] As used herein, the term "purified" indicates that the bacteriophage are removed from manufacturing host bacteria. In particular, a purified bacteriophage has production impurities, such as bacterial components, removed from its manufacturing or production environment. Bacterial components include but are not limited to bacterial host proteins, lipids, and/or bacterial endotoxin. The term "purified" may also refer to genetic purification in which the strain of bacteriophage is genetically homogenous.

[0046] As used herein, the term "substantially purified" refers to a composition containing less than 1%, less than 0.1%, less than 0.001%, or no detectable amount of contaminants such as host bacterial proteins or endotoxin. Also, as used herein, the term "substantially pure" when used to describe a bacteriophage strain refers to the genetic purity of the composition such that the strain is greater than 99%, greater than 99.9%, greater than 99.999%, or 100% of one particular genome sequence.

[0047] Typically, a composition is substantially pure when at least 80%, at least 85%, at least 90%, at least 95%, at least 98%, or at least 99% of the total material (by volume, by wet or dry weight, or by mole percent or mole fraction) in a sample is free of impurities or genetic variants.

[0048] As used herein, the term "subject" or "patient" refers to a human or non-human animal. Preferably, the subject or patient is in need of treatment with the composition as described herein, e.g., has a bacterial infection susceptible to treatment with the composition.

[0049] As used herein, the "synergistic amount" refers to the sum of a first amount (e.g., a bacteriophage) and a second amount (e.g., a different bacteriophage) that results in a synergistic effect (i.e. an effect greater than an additive effect). Therefore, the terms "synergy", "synergism", "synergistic", "combined synergistic amount", and "synergistic therapeutic effect" which are used herein interchangeably, refer to a measured effect of the compound administered in combination where the measured effect is greater than the sum of the individual effects of each of the compounds provided herein administered alone as a single agent.

[0050] As used herein, the term "substantially free" refers to something having less than 10% of the substance that it is to be free from. For example, 0.01% to 10% free of the substance, including any subvalue and subrange therein, including endpoints. For example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10%.

[0051] As used herein, the term "obtainable" as used herein also encompasses the term "obtained." In one embodiment, the term "obtainable" means obtained.

[0052] Additional terms and phrases are defined below.

Bacteriophage Compositions

[0053] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 1.

[0054] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1.

[0055] In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 99.9%, 99.8%, 99.7%, 99.6%, 99.5%, 99.4%, 99.3%, 99.2%, 99.1%, 99.0%, or 99% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 98.9%, 98.8%, 98.7%, 98.6%, 98.5%, 98.4%, 98.3%, 98.2%, 98.1%, 98.0%, or 98% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 97.9%, 97.8%, 97.7%, 97.6%, 97.5%, 97.4%, 97.3%, 97.2%, 97.1%, 97.0% or 97% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 96.9%, 96.8%, 96.7%, 96.6%, 96.5%, 96.4%, 96.3%, 96.2%, 96.1%, 96.0%, or 96% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 95.9%, 95.8%, 95.7%, 95.6%, 95.5%, 95.4%, 95.3%, 95.2%, 95.1%, 95.0%, or 95% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 94.9%, 94.8%, 94.7%, 94.6%, 94.5%, 94.4%, 94.3%, 94.2%, 94.1%, 94.0%, or 94% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 93.9%, 93.8%, 93.7%, 93.6%, 93.5%, 93.4%, 93.3%, 93.2%, 93.1%, 93.0%, or 93% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 92.9%, 92.8%, 92.7%, 92.6%, 92.5%, 92.4%, 92.3%, 92.2%, 92.1%, 92.0%, or 92% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 91.9%, 91.8%, 91.7%, 91.6%, 91.5%, 91.4%, 91.3%, 91.2%, 91.1%, 91.0%, or 91% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 90.9%, 90.8%, 90.7%, 90.6%, 90.5%, 90.4%, 90.3%, 90.2%, 90.1%, 90.0%, or 90% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 89.9%, 89.8%, 89.7%, 89.6%, 89.5%, 89.4%, 89.3%, 89.2%, 89.1%, 89.0%, or 89% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 88.9%, 88.8%, 88.7%, 88.6%, 88.5%, 88.4%, 88.3%, 88.2%, 88.1%, 88.0%, or 88% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 87.9%, 87.8%, 87.7%, 87.6%, 87.5%, 87.4%, 87.3%, 87.2%, 87.1%, 87.0%, or 87% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 86.9%, 86.8%, 86.7%, 86.6%, 86.5%, 86.4%, 86.3%, 86.2%, 86.1%, 86.0%, or 86% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 85.9%, 85.8%, 85.7%, 85.6%, 85.5%, 85.4%, 85.3%, 85.2%, 85.1%, 85.0%, or 85% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 84.9%, 84.8%, 84.7%, 84.6%, 84.5%, 84.4%, 84.3%, 84.2%, 84.1%, 84.0%, or 84% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 83.9%, 83.8%, 83.7%, 83.6%, 83.5%, 83.4%, 83.3%, 83.2%, 83.1%, 83.0%, or 83% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 82.9%, 82.8%, 82.7%, 82.6%, 82.5%, 82.4%, 82.3%, 82.2%, 82.1%, 82.0%, or 82% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 81.9%, 81.8%, 81.7%, 81.6%, 81.5%, 81.4%, 81.3%, 81.2%, 81.1%, 81.0%, or 81% identity to SEQ ID NO: 1. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 80.9%, 80.8%, 80.7%, 80.6%, 80.5%, 80.4%, 80.3%, 80.2%, 80.1%, 80.0%, or 80% identity to SEQ ID NO: 1. In embodiments, the bacteriophage genome comprises the polynucleotide.

[0056] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence identified as SEQ ID NO: 2.

[0057] In an aspect, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the purified bacteriophage includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0058] In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 99.9%, 99.8%, 99.7%, 99.6%, 99.5%, 99.4%, 99.3%, 99.2%, 99.1%, 99.0% or 99% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a bacteriophage that includes a polynucleotide sequence with at least 98.9%, 98.8%, 98.7%, 98.6%, 98.5%, 98.4%, 98.3%, 98.2%, 98.1%, 98.0%, or 98% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 97.9%, 97.8%, 97.7%, 97.6%, 97.5%, 97.4%, 97.3%, 97.2%, 97.1%, 97.0%, or 97% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a bacteriophage that includes a polynucleotide sequence with at least 96.9%, 96.8%, 96.7%, 96.6%, 96.5%, 96.4%, 96.3%, 96.2%, 96.1%, 96.0%, or 96% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 95.9%, 95.8%, 95.7%, 95.6%, 95.5%, 95.4%, 95.3%, 95.2%, 95.1%, 95.0%, or 95% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a bacteriophage that includes a polynucleotide sequence with at least 94.9%, 94.8%, 94.7%, 94.6%, 94.5%, 94.4%, 94.3%, 94.2%, 94.1%, 94.0%, or 94% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 93.9%, 93.8%, 93.7%, 93.6%, 93.5%, 93.4%, 93.3%, 93.2%, 93.1%, 93.0%, or 93% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 92.9%, 92.8%, 92.7%, 92.6%, 92.5%, 92.4%, 92.3%, 92.2%, 92.1%, 92.0%, or 92% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 91.9%, 91.8%, 91.7%, 91.6%, 91.5%, 91.4%, 91.3%, 91.2%, 91.1%, 91.0%, or 91% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 90.9%, 90.8%, 90.7%, 90.6%, 90.5%, 90.4%, 90.3%, 90.2%, 90.1%, 90.0%, or 90% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 89.9%, 89.8%, 89.7%, 89.6%, 89.5%, 89.4%, 89.3%, 89.2%, 89.1%, 89.0%, or 89% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 88.9%, 88.8%, 88.7%, 88.6%, 88.5%, 88.4%, 88.3%, 88.2%, 88.1%, 88.0%, or 88% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 87.9%, 87.8%, 87.7%, 87.6%, 87.5%, 87.4%, 87.3%, 87.2%, 87.1%, 87.0%, or 87% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 86.9%, 86.8%, 86.7%, 86.6%, 86.5%, 86.4%, 86.3%, 86.2%, 86.1%, 86.0%, or 86% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 85.9%, 85.8%, 85.7%, 85.6%, 85.5%, 85.4%, 85.3%, 85.2%, 85.1%, 85.0%, or 85% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 84.9%, 84.8%, 84.7%, 84.6%, 84.5%, 84.4%, 84.3%, 84.2%, 84.1%, 84.0%, or 84% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 83.9%, 83.8%, 83.7%, 83.6%, 83.5%, 83.4%, 83.3%, 83.2%, 83.1%, 83.0%, or 83% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 82.9%, 82.8%, 82.7%, 82.6%, 82.5%, 82.4%, 82.3%, 82.2%, 82.1%, 82.0%, or 82% identity to SEQ ID NO: 2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 81.9%, 81.8%, 81.7%, 81.6%, 81.5%, 81.4%, 81.3%, 81.2%, 81.1%, 81.0%, or 81% identity to SEQ ID NO:2. In embodiments, provided herein is an isolated, purified bacteriophage that includes a polynucleotide sequence with at least 80.9%, 80.8%, 80.7%, 80.6%, 80.5%, 80.4%, 80.3%, 80.2%, 80.1%, 80.0%, or 80% identity to SEQ ID NO: 2. In embodiments, the bacteriophage genome comprises the polynucleotide.

[0059] In an aspect, provided herein are bacteriophage compositions that include one or more bacteriophages.

[0060] In embodiments, provided herein are bacteriophage compositions that include two bacteriophages according to any embodiment described herein. In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophages according to any embodiment described herein. In embodiments, provided herein are bacteriophage compositions that include three or more bacteriophages according to any embodiment described herein. In embodiments, provided herein are bacteriophage compositions include four or more bacteriophages according to any embodiment described herein. In embodiments, provided herein are bacteriophage compositions that include five or more bacteriophages according to any embodiment described herein.

[0061] In embodiments, the composition includes one or more bacteriophages that are resistant to inactivation in the blood. In embodiments, the composition includes two or more bacteriophages that are resistant to inactivation in the blood. In embodiments, the composition includes three or more bacteriophages that are resistant to blood complement inactivation in the blood. In embodiments, the composition includes one or more bacteriophages that are resistant to blood complement C3 protein-mediated inactivation in the blood. In embodiments, the composition includes two or more bacteriophages that are resistant to blood complement C3 protein-mediated inactivation in the blood. In embodiments, the composition includes three or more bacteriophages that are resistant to blood complement C3 protein-mediated inactivation in the blood.

[0062] In embodiments, the composition includes bacteriophages that target Staphylococcus bacteria. In embodiments, the composition includes bacteriophage that target Staphylococcus aureus. In embodiments, the composition includes bacteriophage that target one or more of vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), and/or methicillin-resistant Staphylococcus aureus (MRSA). In embodiments, the composition includes bacteriophage that target vancomycin-intermediate Staphylococcus aureus (VISA). In embodiments, the composition includes bacteriophage that target vancomycin-resistant Staphylococcus aureus (VRSA). In embodiments, the composition includes bacteriophage that target methicillin-resistant Staphylococcus aureus (MRSA).

[0063] In embodiments, the composition includes bacteriophage that infect and kill Staphylococcus bacteria. In embodiments, the composition includes bacteriophage that infect and kill Staphylococcus aureus. In embodiments, the composition includes bacteriophage that infect and kill one or more of VISA, VRSA, and/or MRSA. In embodiments, the composition includes bacteriophage that infect and kill VISA. In embodiments, the composition includes bacteriophage that infect and kill VRSA. In embodiments, the composition includes bacteriophage that infect and kill MRSA.

[0064] In embodiments, provided herein are bacteriophage compositions that include one or more bacteriophages that belong to the genus Silviavirus. In embodiments, the bacteriophage composition includes a strain from bacteriophage genus Silviavirus. In embodiments, the bacteriophage composition includes a bacteriophage selected from MR003 (Accession No. AP019522.1), Qdsa001 (Accession No. KY779848.1), Remus (Accession No. NC_022090.1), Romulus (Accession No. NC_020877.1), SA11 (Accession No. NC_019511.12), StAP1 (Accession No. KC532239.1), and Stsau2 (Accession No. NC_030933.1). In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus Remus. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus SA11. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus Romulus. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus Qdsa001. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus MR003. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus StAP1. In some embodiments of the bacteriophage composition, the bacteriophage is Silviavirus Staphylococcus virus Stsau2.

[0065] In an aspect, provided herein are bacteriophage compositions that include one or more bacteriophages selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the compositions include one or more bacteriophages selected from a bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 9% identity to SEQ ID NO: 2.

[0066] In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 99.9%, 99.8%, 99.7%, 99.6%, 99.5%, 99.4%, 99.3%, 99.2%, 99.1%, 99.0%, or 99% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 98.9%, 98.8%, 98.7%, 98.6%, 98.5%, 98.4%, 98.3%, 98.2%, 98.1%, 98.0%, or 98% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 97.9%, 97.8%, 97.7%, 97.6%, 97.5%, 97.4%, 97.3%, 97.2%, 97.1%, 97.0%, or 97% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 96.9%, 96.8%, 96.7%, 96.6%, 96.5%, 96.4%, 96.3%, 96.2%, 96.1%, 96.0%, or 96% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 95.9%, 95.8%, 95.7%, 95.6%, 95.5%, 95.4%, 95.3%, 95.2%, 95.1%, 95.0%, or 95% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 94.9%, 94.8%, 94.7%, 94.6%, 94.5%, 94.4%, 94.3%, 94.2%, 94.1%, 94.0%, or 94% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 93.9%, 93.8%, 93.7%, 93.6%, 93.5%, 93.4%, 93.3%, 93.2%, 93.1%, 93.0%, or 93% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 92.9%, 92.8%, 92.7%, 92.6%, 92.5%, 92.4%, 92.3%, 92.2%, 92.1%, 92.0%, or 92% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 91.9%, 91.8%, 91.7%, 91.6%, 91.5%, 91.4%, 91.3%, 91.2%, 91.1%, 91.0%, or 91% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 90.9%, 90.8%, 90.7%, 90.6%, 90.5%, 90.4%, 90.3%, 90.2%, 90.1%, 90.0%, or 90% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 89.9%, 89.8%, 89.7%, 89.6%, 89.5%, 89.4%, 89.3%, 89.2%, 89.1%, 89.0%, or 89% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 88.9%, 88.8%, 88.7%, 88.6%, 88.5%, 88.4%, 88.3%, 88.2%, 88.1%, 88.0%, or 88% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 87.9%, 87.8%, 87.7%, 87.6%, 87.5%, 87.4%, 87.3%, 87.2%, 87.1%, 87.0%, or 87% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 86.9%, 86.8%, 86.7%, 86.6%, 86.5%, 86.4%, 86.3%, 86.2%, 86.1%, 86.0%, or 86% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 85.9%, 85.8%, 85.7%, 85.6%, 85.5%, 85.4%, 85.3%, 85.2%, 85.1%, 85.0%, or 85% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 84.9%, 84.8%, 84.7%, 84.6%, 84.5%, 84.4%, 84.3%, 84.2%, 84.1%, 84.0%, or 84% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 83.9%, 83.8%, 83.7%, 83.6%, 83.5%, 83.4%, 83.3%, 83.2%, 83.1%, 83.0%, or 83% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 82.9%, 82.8%, 82.7%, 82.6%, 82.5%, 82.4%, 82.3%, 82.2%, 82.1%, 82.0%, or 82% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 81.9%, 81.8%, 81.7%, 81.6%, 81.5%, 81.4%, 81.3%, 81.2%, 81.1%, 81.0%, or 81% identity to SEQ ID NO: 1. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 80.9%, 80.8%, 80.7%, 80.6%, 80.5%, 80.4%, 80.3%, 80.2%, 80.1%, 80.0%, or 80% identity to SEQ ID NO: 1. In embodiments, the bacteriophage genome comprises the polynucleotide.

[0067] In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 99.9%, 99.8%, 99.7%, 99.6%, 99.5%, 99.4%, 99.3%, 99.2%, 99.1%, 99.0%, or 99% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 98.9%, 98.8%, 98.7%, 98.6%, 98.5%, 98.4%, 98.3%, 98.2%, 98.1%, 98.0%, or 98% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 97.9%, 97.8%, 97.7%, 97.6%, 97.5%, 97.4%, 97.3%, 97.2%, 97.1%, 97.0%, or 97% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 96.9%, 96.8%, 96.7%, 96.6%, 96.5%, 96.4%, 96.3%, 96.2%, 96.1%, 96.0%, or 96% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 95.9%, 95.8%, 95.7%, 95.6%, 95.5%, 95.4%, 95.3%, 95.2%, 95.1%, 95.0%, or 95% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 94.9%, 94.8%, 94.7%, 94.6%, 94.5%, 94.4%, 94.3%, 94.2%, 94.1%, 94.0%, or 94% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 93.9%, 93.8%, 93.7%, 93.6%, 93.5%, 93.4%, 93.3%, 93.2%, 93.1%, 93.0%, or 93% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 92.9%, 92.8%, 92.7%, 92.6%, 92.5%, 92.4%, 92.3%, 92.2%, 92.1%, 92.0%, or 92% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 91.9%, 91.8%, 91.7%, 91.6%, 91.5%, 91.4%, 91.3%, 91.2%, 91.1%, 91.0%, or 91% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 90.9%, 90.8%, 90.7%, 90.6%, 90.5%, 90.4%, 90.3%, 90.2%, 90.1%, 90.0%, or 90% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 89.9%, 89.8%, 89.7%, 89.6%, 89.5%, 89.4%, 89.3%, 89.2%, 89.1%, 89.0%, or 89% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 88.9%, 88.8%, 88.7%, 88.6%, 88.5%, 88.4%, 88.3%, 88.2%, 88.1%, 88.0%, or 88% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 87.9%, 87.8%, 87.7%, 87.6%, 87.5%, 87.4%, 87.3%, 87.2%, 87.1%, 87.0%, or 87% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 86.9%, 86.8%, 86.7%, 86.6%, 86.5%, 86.4%, 86.3%, 86.2%, 86.1%, 86.0%, or 86% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 85.9%, 85.8%, 85.7%, 85.6%, 85.5%, 85.4%, 85.3%, 85.2%, 85.1%, 85.0%, or 85% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 84.9%, 84.8%, 84.7%, 84.6%, 84.5%, 84.4%, 84.3%, 84.2%, 84.1%, 84.0%, or 84% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 83.9%, 83.8%, 83.7%, 83.6%, 83.5%, 83.4%, 83.3%, 83.2%, 83.1%, 83.0%, or 83% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 82.9%, 82.8%, 82.7%, 82.6%, 82.5%, 82.4%, 82.3%, 82.2%, 82.1%, 82.0%, or 82% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 81.9%, 81.8%, 81.7%, 81.6%, 81.5%, 81.4%, 81.3%, 81.2%, 81.1%, 81.0%, or 81% identity to SEQ ID NO: 2. In embodiments, the bacteriophage composition includes a bacteriophage that includes a polynucleotide sequence with at least 80.9%, 80.8%, 80.7%, 80.6%, 80.5%, 80.4%, 80.3%, 80.2%, 80.1%, 80.0%, or 80% identity to SEQ ID NO: 2. In embodiments, the bacteriophage genome comprises the polynucleotide.

[0068] In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophages selected from bacteriophage including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2; and where the composition's target bacteria range is broader than the cumulative range of the individual bacteriophage in the composition. In another aspect, the bacteriophages compositions may include two or more bacteriophages selected from bacteriophages including a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2; and where the composition's target bacteria range is broader than the cumulative range of the individual bacteriophage in the composition.

[0069] In embodiments, the bacteriophage composition includes one or more additional bacteriophages. In some embodiments, the one or more additional bacteriophages are suitable for treating a bacterial infection, in particular a Staphylococcus infection. In embodiments, the additional one or more phage can be natural or non-naturally occurring. In embodiments, the one or more additional phage can be a phage with at least 80% nucleic acid sequence identity to any of the phage described herein. In embodiments, the one or more additional phage can be a phage with at least 80% nucleic acid sequence identity to SEQ ID NO: 1. In embodiments, the one or more additional phage can be a phage with at least 80% nucleic acid sequence identity to SEQ ID NO: 2. In embodiments, the bacteriophage include a polynucleotide sequence with at least 80% but not 100% identity to any one of SEQ ID NO: 1 or SEQ ID NO: 2.

[0070] In embodiments, the range of target bacteria of the bacteriophage composition is broader than the range of target bacteria of any single bacteriophage included within the composition. Such activity can be considered synergistic as the effect of the composition (target killing range) is greater than the sum of individual effects (target killing range) of each component bacteriophage. In embodiments, provided herein are bacteriophage compositions where the composition's target bacteria range can have an effectiveness that is greater than the sum of effectiveness of the individual bacteriophage.

[0071] In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophages, where the composition includes a bacteriophage with polynucleotide sequence of SEQ ID NO: 1 and the composition targets more Staphylococcus aureus strains than a bacteriophage with polynucleotide sequence of SEQ ID NO: 1. In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes a bacteriophage with a polynucleotide sequence with at least 93% identity with SEQ ID NO: 1 and the composition targets more Staphylococcus aureus strains than a bacteriophage with a polynucleotide sequence with at least 93% identity with SEQ ID NO: 1. In embodiments, the composition includes a bacteriophage with a polynucleotide sequence with at least 90% identity with SEQ ID NO: 1 and the composition targets more Staphylococcus aureus strains than a bacteriophage with a polynucleotide sequence with at least 90% identity with SEQ ID NO: 1. In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophages, where the composition includes a bacteriophage with polynucleotide sequence of SEQ ID NO: 2 and the composition targets more Staphylococcus aureus strains than a bacteriophage with polynucleotide sequence of SEQ ID NO: 2. In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes a bacteriophage with a polynucleotide sequence with at least 93% identity with SEQ ID NO: 2 and the composition targets more Staphylococcus aureus strains than a bacteriophage with a polynucleotide sequence with at least 93% identity with SEQ ID NO: 2. In embodiments, provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes a bacteriophage with a polynucleotide sequence with at least 90% identity with SEQ ID NO: 2 and the composition targets more Staphylococcus aureus strains than a bacteriophage with a polynucleotide sequence with at least 90% identity with SEQ ID NO: 2. In embodiments, the compositions can have any combination polynucleotide sequences of SEQ ID NO: 1 and SEQ ID NO: 2.

[0072] Provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes at least one bacteriophage that is genetically modified. Provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes at least one naturally occurring phage. Provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition excludes naturally occurring phage. Provided herein are bacteriophage compositions that include two or more bacteriophage, where the composition includes one or more bacteriophage that is resistant to inactivation by the blood complement system.

[0073] In embodiments, the bacteriophage composition includes an additional component selected from a pharmaceutically acceptable carrier, diluent, excipient and combinations thereof. In embodiments, the bacteriophage composition includes a pharmaceutically acceptable carrier. In embodiments, the bacteriophage composition includes a diluent. In embodiments, the bacteriophage composition includes an excipient. In embodiments, the bacteriophage composition includes a combination of a pharmaceutically acceptable carrier, diluent, and an excipient. In embodiments, the bacteriophage composition includes a combination of a pharmaceutically acceptable carrier and diluent. In embodiments, the bacteriophage composition includes a combination of a pharmaceutically acceptable carrier and an excipient. In embodiments, the bacteriophage composition includes a combination of a diluent and an excipient.

[0074] In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 8.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 7.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 6.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 5.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 4.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 3.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 2.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 1.degree. C. In embodiments, the bacteriophage composition includes a storage media for storage at a temperature at or below 0.degree. C.

[0075] In embodiments, the bacteriophage composition is in a liquid, semi-liquid, solid, frozen, or lyophilized formulation. In embodiments, the bacteriophage composition is in a liquid formulation. In embodiments, the bacteriophage composition is in a semi-liquid formulation. In embodiments, the bacteriophage composition is in a solid formulation. In embodiments, the bacteriophage composition is in a frozen formulation. In embodiments, the bacteriophage composition is in a lyophilized formulation.

[0076] In embodiments, the bacteriophage composition is stored in containers containing from about 1 ml to about 5 ml injectable solution. In some embodiments, this includes single dose containers for single use. In other embodiments, this may include multi-dose containers containing injection solutions that provide multiple doses of the bacteriophage composition described herein. The composition may also be stored in various suitable containers, including, but not necessarily limited to, vials, cuvettes, cartridges, prefilled syringes, plastic bags, ampoules, bottles, pouches, pumps, sprayers, stoppers, needles, plungers, caps, stents, catheters, implants, or blister packages. In some embodiments, the aforementioned containers may be made of glass or plastic, or they may be plastic-coated, or may be made of various other suitable materials. Containers may be clear, or may provide protection from light by being amber colored or of various other colors, or may be wrapped in aluminum foil.

[0077] In some embodiments (alternatively or additionally), a "mutant" bacteriophage is capable of lysing some or all the same target bacterial strains as one or more of ARSA0001 and/or ARSA0002, and/or further capable of lysing one or more additional bacterial strains. In one embodiment, a mutant may have at least 90, 91, 92, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to a nucleic acid sequence of one or more of ARSA0001 and ARSA0002. In some embodiments, a mutant or variant may have at least 90, 91, 92, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity across its entire genome sequence when compared to one or more of the genome sequence of ARSA0001 and ARSA0002. In one embodiment, a mutant may have at least 90, 91, 92, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity across its entire genome sequence when compared to SEQ ID NO.: 1. In one embodiment, a mutant may have at least 90, 91, 92, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity across its entire genome sequence when compared to SEQ ID NO.: 2.

[0078] In embodiments, a "mutant" may be a bacteriophage progeny. A bacteriophage progeny may be a bacteriophage obtainable after lysing Staphylococcus (e.g., S. aureus) target bacteria using a bacteriophage as described herein (i.e., the "parent bacteriophage"). In other words, the bacteriophage progeny may be a second (or further) generation bacteriophage.

[0079] In embodiments, "genetically modified" may be a bacteriophage whose polynucleotide sequence has been altered by genetic engineering techniques. Genetic engineering of polynucleotide sequences can be achieved by any modern molecular biology technique well known in the art, including but not limited to homologous recombination, bacteriophage engineering, CRISPR-Cas based manipulation, transformation of full-length naked phage into a host bacteria, and any combinations of techniques thereof.

[0080] In embodiments, a bacteriophage progeny is obtainable by contacting one or more bacteriophage(s) described herein, including for example, one selected from ARSA0001 or ARSA0002, with a Staphylococcus target bacteria such that the one or more bacteriophage(s) infects and lyses the target bacteria; and obtaining a bacteriophage released following lysis of the target bacteria. The bacteriophage progeny will typically comprise one or more nucleotide(s) mutation(s) when compared to the relevant parent bacteriophage.

[0081] In embodiments, the bacteriophage may be provided in the form of a single therapeutic composition or as a number of separate compositions each comprising one or more bacteriophage components of the composition. In embodiments where the bacteriophages are provided in a number of separate compositions, the bacteriophages may be administered to a subject sequentially or simultaneously (suitably simultaneously).

[0082] In embodiments, the bacteriophage composition includes bacteriophage concentrations between 1.times.10.sup.5 and 1.times.10.sup.11 PFU per ml of each bacteriophage. In embodiments, the bacteriophage composition includes bacteriophage concentrations between 1.times.10.sup.6 and 1.times.10.sup.11 PFU per ml of each bacteriophage. In embodiments, the bacteriophage composition includes bacteriophage concentrations between 1.times.10.sup.7 and 1.times.10.sup.11 PFU per ml of each bacteriophage. In some embodiments, the bacteriophage composition includes bacteriophage concentrations between 1.times.10.sup.8 and 1.times.10.sup.11 PFU per ml of each bacteriophage. In some embodiments, the composition includes 1.times.10.sup.8 to 1.times.10.sup.9 PFU, 1.times.10.sup.8 to 1.times.10.sup.10 PFU, 1.times.10.sup.8 to 1.times.10.sup.11 PFU, 1.times.10.sup.9 to 1.times.10.sup.10 PFU, 1.times.10.sup.9 to 1.times.10.sup.11 PFU, or 1.times.10.sup.10 to 1.times.10.sup.11 PFU of each phage per ml of composition. In some embodiments, a bacteriophage composition is administered to a subject at a dosage of at least about 1.times.10.sup.8 PFU of each phage, at least about 1.times.10.sup.9 PFU of each phage, at least about 1.times.10.sup.10 PFU of each phage, or at least about 1.times.10.sup.11 PFU of each phage per ml of composition. In embodiments, one or more bacteriophage(s) may be combined to form a composition that includes 1.times.10.sup.8, 1.times.10.sup.9 or 1.times.10.sup.10, or 1.times.10.sup.11 PFU of each phage per ml of composition. Concentrations include any value or range within the recited ranges, including endpoints. In specific embodiments, the composition may be administered at a dosage of at least 1.times.10.sup.8 PFU of total bacteriophages per milliliter. In specific embodiments, the composition may be administered at a dosage of at least 1.times.10.sup.9 PFU of total bacteriophages per milliliter.

[0083] In some embodiments, the total dosage may vary depending on the formulation and storage container. In some embodiments, the total dosage may be lower or higher when administered to the patient, depending on whether it is delivered from a single-dose pre-filled syringe, or a multi-dose container. In some embodiments, the bacteriophage composition may be administered at a basal dose rate or a bolus rate. In some embodiments, the bacteriophage composition may be administered by an IV fluid drip.

[0084] In embodiments, the bacteriophage composition is stored at a range between 2-8.degree. C. In some embodiments, the bacteriophage composition is stored between 2 and 3.degree. C. In some embodiments, the bacteriophage composition is stored between 2 and 4.degree. C. In some embodiments, the bacteriophage composition is stored between 2 and 5.degree. C. In some embodiments, the bacteriophage composition is stored between 2 and 6.degree. C. In some embodiments, the bacteriophage composition is stored between 2 and 7.degree. C. In some embodiments, the bacteriophage composition is stored between 3 and 4.degree. C. In some embodiments, the bacteriophage composition is stored between 3 and 5.degree. C. In some embodiments, the bacteriophage composition is stored between 3 and 6.degree. C. In some embodiments, the bacteriophage composition is stored between 3 and 7.degree. C. In some embodiments, the bacteriophage composition is stored between 3 and 8.degree. C. In some embodiments, the bacteriophage composition is stored between 4 and 5.degree. C. In some embodiments, the bacteriophage composition is stored between 4 and 6.degree. C. In some embodiments, the bacteriophage composition is stored between 4 and 7.degree. C. In some embodiments, the bacteriophage composition is stored between 4 and 8.degree. C. In some embodiments, the bacteriophage composition is stored between 5 and 8.degree. C. In some embodiments, the bacteriophage composition is stored between 5 and 6.degree. C. In some embodiments, the bacteriophage composition is stored between 5 and 7.degree. C. In some embodiments, the bacteriophage composition is stored between 6 and 8.degree. C. In some embodiments, the bacteriophage composition is stored between 6 and 7.degree. C. In some embodiments, the bacteriophage composition is stored between 7 and 8.degree. C. In some embodiments, the bacteriophage composition is stored at 2, 3, 4, 5, 6, 7, or 8.degree. C. The temperature may be any value or subrange within the recited ranges, including endpoints.

[0085] In embodiments, the bacteriophage composition is stored at room temperature. In embodiments, the bacteriophage composition is stored at about 20-30.degree. C. In embodiments, the bacteriophage composition is stored at about 20-25.degree. C. In embodiments, the bacteriophage composition is stored at about 20-22.degree. C. In embodiments, the bacteriophage composition is stored at about 20.degree. C. In embodiments, the bacteriophage composition is stored at about 21.degree. C. In embodiments, the bacteriophage composition is stored at about 22.degree. C. In embodiments, the bacteriophage composition is stored at 23.degree. C. In embodiments, the bacteriophage composition is stored at 24.degree. C. In embodiments, the bacteriophage composition is stored at 25.degree. C. The temperature may be any value or subrange within the recited ranges, including endpoints.

[0086] In embodiments, the bacteriophage composition is resistant to inactivation by the immune system of a subject. In some embodiments, the bacteriophage is resistant to inactivation by the mononuclear phagocytosis system of a subject. In some embodiments, the bacteriophage is resistant to inactivation by the complement system of a subject. In some embodiments, the bacteriophage is resistant to inactivation by the blood complement system of a subject. In some embodiments, the bacteriophage is resistant to inactivation by the blood complement C3-complex of proteins of a subject.

[0087] In embodiments, the bacteriophage composition includes at least one lytic bacteriophage. In some embodiments, the bacteriophage includes at least one lytic phage that can kill a bacterium and release phage progeny through cell lysis.

[0088] In an aspect, provided herein is a bacterial host manufacturing strain including a bacteriophage where the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, provided herein is a bacterial host manufacturing strain including a bacteriophage where the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0089] In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 1. In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 2. In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of with at least 93% identity to SEQ ID NO: 1. In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In other embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of with at least 90% identity to SEQ ID NO: 1. In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage that includes a polynucleotide sequence of polynucleotide sequence with at least 90% identity to SEQ ID NO: 2. In embodiments, provided herein is a bacterial host manufacturing strain including a bacteriophage according to any of the various embodiments described herein.

[0090] In embodiments, provided herein are uses of a composition according to any of the various embodiments described herein in the treatment of a Staphylococcus aureus infection in a subject. In embodiments, the use includes administering a composition according to any of the embodiments described herein to a subject suffering from a Staphylococcus aureus infection.

[0091] In embodiments, provided herein are uses of a composition including one or more distinct bacteriophages that target Staphylococcus aureus in the treatment of subject with a Staphylococcus aureus bacterial infection. The uses include administering the composition to said subject; wherein at least one of the bacteriophage is selected from a bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. The uses may include administering the composition to said subject; wherein at least one of the bacteriophage is selected from a bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

Methods of Use

[0092] In an aspect, provided herein are methods of treating a subject with a bacterial infection including selecting a bacteriophage based upon resistance to blood complement inactivation and administering the bacteriophage to the subject.

[0093] In embodiments, selecting a bacteriophage includes performing a blood/serum resistance assay and selecting bacteriophage based on survival in the blood/serum for a pre-determined amount of time.

[0094] In an aspect, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage selected from a bacteriophage including a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage selected from a bacteriophage including a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2. In an aspect, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage as described in any embodiment herein.

[0095] In embodiments, provided herein are methods of treating a subject with a bacterial infection. In some embodiments, the bacterial infection at least partially includes Staphylococcus. In some embodiments, the bacterial infection at least partially includes Staphylococcus aureus. In some embodiments, the bacterial infection includes Staphylococcus aureus strains resistant to chemical antibiotics. In some embodiments, the bacterial strains include drug resistant and/or multi-drug resistant Staphylococcus aureus strains. In some embodiments, the bacterial strain is the drug-resistant strain vancomycin-intermediate Staphylococcus aureus (VISA). In some embodiments, the bacterial strain is the drug-resistant strain vancomycin-resistant Staphylococcus aureus (VRSA). In some embodiments, the bacterial strain is the drug-resistant strain methicillin-resistant Staphylococcus aureus (MRSA).

[0096] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation in the blood. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation by a blood complement system. In embodiments, the bacteriophage can be any bacteriophage as described herein.

[0097] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence of SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence with at least 93% identity to a SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence with at least 90% identity to a SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0098] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that infects and kills one or more of vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), methicillin-resistant Staphylococcus aureus (MRSA). In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that infects and kills vancomycin-intermediate Staphylococcus aureus (VISA). In embodiments, the bacteriophage composition includes bacteriophage that infects and kills vancomycin-resistant Staphylococcus aureus (VRSA). In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that infects and kills methicillin-resistant Staphylococcus aureus (MRSA).

[0099] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophages. In embodiments, the one or more bacteriophages are suitable for treating a bacterial infection, in particular a Staphylococcus infection. In embodiments, the bacteriophage includes one or more additional phages and can be a phage with 93%-100% nucleic acid sequence identity to any of the phage described herein. The bacteriophage can have a polynucleotide sequence, that includes a polynucleotide sequence having at least 93% but not 100% identity to any one of SEQ ID NO: 1 or SEQ ID NO: 2. In embodiments, the bacteriophage includes one or more additional phages and can be a phage with 90%-100% nucleic acid sequence identity to any of the phage described herein. The bacteriophage can have a polynucleotide sequence, that includes a polynucleotide sequence having at least 90% but not 100% identity to any one of SEQ ID NO: 1 or SEQ ID NO: 2. Percent identity may be any value or subrange within the recited ranges, including endpoints.

[0100] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes one or more bacteriophage and the composition's target bacteria range can be broader than the range of any individual bacteriophage or the phage collectively in the composition, or have an effectiveness that is greater than the sum of effectiveness of the individual bacteriophage. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with polynucleotide sequence SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 90% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 91% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 92% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 93% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 94% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 95% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 96% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 97% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 98% identity with SEQ ID NO: 1. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 99% identity with SEQ ID NO: 1.

[0101] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with polynucleotide sequence SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 90% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 91% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 92% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 93% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 94% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 95% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 96% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 97% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 98% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes a bacteriophage with a polynucleotide sequence at least 99% identity with SEQ ID NO: 2. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that have any combination polynucleotide sequences of SEQ ID NO: 1 and SEQ ID NO: 2.

[0102] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes at least one bacteriophage that is genetically modified. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes at least one naturally occurring phage or can exclude naturally occurring phage. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes at least one lytic phage. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage composition that includes at least one bacteriophage resistant to inactivation by the blood complement system.

[0103] In an aspect, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus bacteria, where the bacteriophage includes a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In another aspect, the bacteriophage may include a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0104] In embodiments, modifying the microbial flora includes killing the majority of a particular bacterial strain in the microbial flora, limiting growth a particular bacterial strain in the microbial flora, and/or slowing the growth of a particular bacterial strain in the microbial flora. In embodiments, modifying the microbial flora includes killing the majority of a particular bacterial strain in the microbial flora. In embodiments, modifying the microbial flora includes limiting growth a particular bacterial strain in the microbial flora. In embodiments, modifying the microbial flora includes slowing the growth of a particular bacterial strain in the microbial flora.

[0105] In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject a bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence of SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence of SEQ ID NO: 2. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that targets Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0106] In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject a bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence of SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence of SEQ ID NO: 2. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 93% identity to SEQ ID NO: 2. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage that infects and kills Staphylococcus aureus bacteria, where the bacteriophage includes a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

[0107] In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject a bacteriophage that that is genetically modified. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one naturally occurring bacteriophage or can exclude naturally occurring phage. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one lytic phage. In embodiments, provided herein are methods of modifying the microbial flora in a subject including administering to the subject at least one bacteriophage resistant to inactivation by the blood complement system.

[0108] In embodiments, provided herein are methods for administering a bacteriophage to a subject, where the bacteriophage includes a bacteriophage concentration range between 1.times.10.sup.8 and 1.times.10.sup.11 PFU per ml of each bacteriophage. In some embodiments, the bacteriophage concentration is 1.times.10.sup.8 to 1.times.10.sup.9 PFU, 1.times.10.sup.8 to 1.times.10.sup.10 PFU, or 1.times.10.sup.8 to 1.times.10.sup.11 PFU of each phage per ml of composition. In some embodiments, the bacteriophage concentration is 1.times.10.sup.9 to 1.times.10.sup.10 PFU, or 1.times.10.sup.9 to 1.times.10.sup.11 PFU of each phage per ml of composition. In some embodiments, the bacteriophage concentration is 1.times.10.sup.10 to 1.times.10.sup.11 PFU of each phage per ml of composition. In some embodiments, the bacteriophage is administered to a subject at a dosage of at least about 1.times.10.sup.8 PFU of each phage, at least about 1.times.10.sup.9 PFU of each phage, at least about 1.times.10.sup.10 PFU of each phage, or at least about 1.times.10.sup.11 PFU of each phage per ml of composition. In embodiments, one or more bacteriophage(s) may be combined to form a total concentration of 1.times.10.sup.8, 1.times.10.sup.9, 1.times.10.sup.10, or 1.times.10.sup.11 PFU of each phage per ml of composition. Concentrations include any value or range within the recited ranges, including endpoints.

[0109] In embodiments, the methods provided herein include administering a bacteriophage, where at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 81% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 82% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 83% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 84% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 85% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 86% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 87% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 88% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 89% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 90% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 90% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 92% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 93% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 94% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 95% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 96% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 97% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 98% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In embodiments, the methods provided herein include administering a bacteriophage, where at least about 99% of bacteriophage retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes. In specific embodiments, the time period is between about 10 minutes and about 90 minutes.

[0110] In embodiments, the methods provided herein include administering a bacteriophage, where at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 20 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 30 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 40 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 50 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 60 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 10 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 30 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 40 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 50 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 60 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 20 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 40 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 50 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 60 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 30 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 50 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 60 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 90 minutes. In some embodiments, the bacteriophage is administered to a subject for a time between 40 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 40 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 60 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 50 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 70 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 60 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 70 and 80 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 70 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 70 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 70 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 70 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 80 and 90 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 80 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 80 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 80 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 90 and 100 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 90 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 90 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 100 and 110 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 100 and 120 minutes. In some embodiments, at least about 80% of bacteriophage retain lytic activity after exposure to human plasma for a time period between 110 and 120 minutes. The amount of time may be any value or subrange within the recited ranges, including endpoints. The bacteriophage composition retains at least greater than 80% of its lytic activity in human plasma at the end of the time point.

[0111] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is at least partially resistant to inactivation by immune system of the administered subject. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation by the mononuclear phagocytosis system of the administered subject. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation by the complement system of the administered subject. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation by the blood complement system of the administered subject. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage that is resistant to inactivation by the blood complement C3-complex of proteins of the administered subject.

[0112] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophages that belong to the genus Silviavirus. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject a bacteriophage strain from the bacteriophage genus Silviavirus. In embodiments, the bacteriophage includes a bacteriophage selected from MR003 (Accession No. AP019522.1), Qdsa001 (Accession No. KY779848.1), Remus (Accession No. NC_022090.1), Romulus (Accession No. NC_020877.1), SA11 (Accession No. NC_019511.12), StAP1 (Accession No. KC532239.1), and Stsau2 (Accession No. NC_030933.1). In embodiments, the bacteriophage is Silviavirus Staphylococcus virus Remus. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus SA11. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus Romulus. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus Qdsa001. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus MR003. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus StAP1. In embodiments, the bacteriophage is Silviavirus Staphylococcus virus Stsau2.

[0113] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophage administered intravenously. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophage administered via an intra-articular injection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophage administered via inhalation. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophages administered via nebulization. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to a subject one or more bacteriophages administered intranasally, orally, by inhalation, vaginally, rectally, or parenterally, for example by intradermal, subcutaneous, intramuscular, intraperitoneal, intrarectal, intraarterial, intralymphatic, intravenous, intra-articular, intrathecal, and intratracheal routes. Parenteral administration, if used, is generally characterized by injection.

[0114] In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage. In embodiments, the bacterial infection is selected from bacteremia, septicemia, pulmonary infection, rhinosinusitis, urinary tract infection, intra-abdominal infection, skin infection, skin structure infection, endocarditis, and an implant infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is bacteremia. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is septicemia. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is pulmonary infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is rhinosinusitis. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is urinary tract infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is intra-abdominal infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is skin infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is skin structure infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is endocarditis. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is an implant infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is a cardiac implant infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is a cardiac implant infection caused by a ventricular assist device. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is a cardiac implant infection caused by a pacemaker. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is a prosthetic joint infection. In embodiments, provided herein are methods of treating a subject with a bacterial infection including administering to the subject one or more distinct bacteriophage, where the bacterial infection is prosthetic valve endocarditis. In embodiments, the bacterial infection is resistant to one or more antibiotics.

[0115] In embodiments, provided herein are methods for treating bacterial infection by administering any bacteriophage composition described herein in combination with an antibiotic. In embodiments, the antibiotic is selected from the group consisting of a fluoroquinolone, carbapenem, aminoglycoside, ansamycin, cephalosporin, penicillin, beta lactam, beta lactamase inhibitor, folate pathway inhibitor, fucidane, glycopeptide, glycylcycline, lincosamide, lipopeptide, macrolide, oxazolidinone, phenicol phosphonic acid, streptogramin, and tetracycline.

[0116] In embodiments, provided herein are methods of administering to a subject any of the bacteriophage described herein, where administration is over a range of about 6 to about 24 hours. In embodiments, the bacteriophage is administered to a subject every 6 hours. In some embodiments, the bacteriophage is administered to a subject every 12 hours. In embodiments, the bacteriophage is administered to a subject every 18 hours. In embodiments, the bacteriophage is administered to a subject every 24 hours.

[0117] In embodiments, provided herein are methods of administering to a subject any of the bacteriophage described herein for up to 7 days. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of one dose. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of two doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of three doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of four doses (1 day). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of five doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of six doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of seven doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of eight doses (2 days). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of nine doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of ten doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of eleven doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twelve doses (3 days). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of thirteen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of fourteen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of fifteen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of sixteen doses (4 days). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of seventeen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of eighteen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of nineteen doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty doses (5 days). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-one doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-two doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-three doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-four doses (6 days). In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-five doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-six doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-seven doses. In some embodiments, the bacteriophage is administered to a subject every 6 hours for a maximum of twenty-eight doses (7 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of one dose. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of two doses (1 day). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of three doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of four doses (2 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of five doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of six doses (3 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of seven doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of eight doses (4 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of nine doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of ten doses (5 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of eleven doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of twelve doses (6 days). In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of thirteen doses. In some embodiments, the bacteriophage is administered to a subject every 12 hours for a maximum of fourteen doses (7 days). In some embodiments, the bacteriophage is administered to a subject every 18 hours. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of one dose. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of two doses. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of three doses. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of four doses (3 days). In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of five doses. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of six doses. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of seven doses. In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of eight doses (6 days). In some embodiments, the bacteriophage is administered to a subject every 18 hours for a maximum of nine doses. In some embodiments, the bacteriophage is administered to a subject every 24 hours. In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of one (1 day). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of two (2 days). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of three (3 days). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of four (4 days). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of five (5 days). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum dose of six (6 days). In some embodiments, the bacteriophage is administered to a subject every 24 hours for a maximum duration of seven (7 days). In some embodiments, the bacteriophage is administered for at least 7 days. In some embodiments, the bacteriophage is administered for at least 14 days. In some embodiments, the bacteriophage is administered for at least 21 days. In some embodiments, the bacteriophage is administered for at least 28 days. In some embodiments, the bacteriophage is administered for at least one month. In some embodiments, the bacteriophage is administered for at least 2 months.

[0118] In embodiments, is a method of administration of a bacteriophage composition to a subject where the subject is human.

EXAMPLES

Example 1: AP-SA02 Product Optimization

[0119] Experiments were conducted to create a bacteriophage therapy that met the following criteria: 1) Obligately lytic, to avoid specialized transduction of bacterial genes; 2) Not known, by empirical testing and/or inference from genomics, to be prone to generalized transduction, and 3) Fully sequenced, to avoid phages with genes known to carry antibiotic resistance or bacterial virulence genes.

[0120] Collectively, the phages used together to treat a subject should: 1) Have broad activity against the target pathogen but not other species, to maximize potential utility and minimize off-target effects, and 2) Be capable of complementation, in which resistant mutants arising to one phage are sensitive to another phage.

[0121] In addition to characteristics of the phages themselves, material for clinical use should be produced in such a way as to give confidence that the final product retains these characteristics (i.e. are still the same phages) and does not contain potentially harmful (or harmful amounts) of impurities such as endotoxin or host cell proteins.

[0122] Each of the phages were identified by acquiring a diverse panel of MRSA isolates and several VRSA strains that were then screened against a variety of phages to identify phages that exhibited both broad host range coverage and robust potency. Similar to antibiotics, bacteria are considered susceptible to phage if the minimum inhibitory concentration is less or equal to the susceptibility breakpoint of 10.sup.3 phage/mL which corresponds to 0.1 pg/mL of protein.

[0123] Each of the phage candidates was then advanced through a series of selection criteria and different methods, including sequencing, bioinformatics and comparative genomics, in order to identify potential receptors, phage identity and confirm lytic activity. This process yielded a smaller candidate phage pool with the desired attributes for a product candidate, namely, broad host range, complementarity, compatibility and targeting different bacterial receptors which are essential intrinsic attributes that contribute to the robustness and potency of the therapeutic cocktail. Complementarity aims to ensure that a clinical isolate is targeted by more than one phage which limits the emergence of resistance. Targeting different receptors on the surface of bacteria also contributes to resistance prevention and also has the potential to decrease bacterial virulence and fitness. Compatibility between different components of the multi-phage product ensures that the activity of one phage does not interfere with the infectivity of another phage.

[0124] Phage candidates were then validated for efficacy and potency. Specifically, this included performing killing kinetic assays to demonstrate cooperativity, activity in bodily fluids and in the presence of current anti-Staphylococcal therapies in vitro and biofilm inactivation.

[0125] Phages were also selected based on manufacturing feasibility and process optimization efforts with the goal of achieving high-quality phage product free host cell proteins and other contaminants whilst maintaining adequate phage titers. Equally important, the ability to formulate phage components in the same diluent suitable for inhalation and intravenous (IV) delivery that would allow long term stability is an important consideration in the selection process.

Example 2: Selection of Phage Components for Optimized Product AP-SA02

[0126] Host range and potency. The host range of SA phage is generally above 80% (Table 1), yet their potency is variable. While phages belonging to the family Kayvirus, such as Sa87, have a broad host range, their potency is not ideal. By contrast, as exemplified by plaque turbidity, Silviaviruses such as ARSA0001 are extremely potent and completely eliminate bacteria, which results in the formation of clear plaques and very high efficiencies of plating (FIG. 1). ARSA0001 potency was further demonstrated by the failure of attempts to obtain phage-resistant bacteria.

TABLE-US-00001 TABLE 1 % S. aureus Phage Family Isolates Sensitive J-Sa36 Kayvirus 83 Sa83 Kayvirus 86 Sa87 Kayvirus 92 ARSA0001 Silviavirus 83 ARSA0002 Silviavirus 91

[0127] Compatibility with relevant biological fluids. A criterion for lead candidate selection is phage activity in bodily fluids to ensure that infectivity is not locally or systemically inhibited. To ensure in vivo efficacy, the viability of individual phage after exposure to human blood and plasma was evaluated. Phages were diluted to a concentration of 10.sup.7 phage/mL into plasma obtained from three healthy volunteers or phage buffer and incubated at 37.degree. C. The activity of each phage component was assessed by using a standard double-agar layer plaque assay. Ten (10) S. aureus phages were screened and most were partially inactivated within 60 minutes of exposure to blood or plasma compared to phage diluent (Table 2). The lack of recovery after exposure to blood was abolished by heat inactivation of serum and the complement inhibitor compstatin, suggesting that these phages are inhibited by complement (FIG. 2). No significant loss in phage titer was observed for 2 lead candidates, namely ARSA0001 and ARSA0002.

TABLE-US-00002 TABLE 2 Phage % Recovery J-Sa36 0.06 Sa83 0.95 Sa87 6.33 ARSA0003 1.07 Sa474 0.03 ARSA0001 93.94 ARSA0004 1.76 Sa101 0.05 Sa68 0.71 ARSA0002 94.44

[0128] Next, the activity of Sa87, ARSA0001 and ARSA0002 was assessed at 90 minutes after exposure to plasma obtained from 6 subjects to ensure that the inhibition is not donor specific (FIG. 3). Since all phages from AP-SA01 are highly related, Sa87 was selected as an example of a Kayvirus. A significant loss of activity was observed only in the case of Sa87. Recently published data also suggested that S. aureus phage may not retain full activity in human blood. The data herein demonstrate that antimicrobial activity of ARSA0001 and ARSA0002 is not inhibited by blood components and these viruses are suitable therapeutic candidates.

Example 3: AP-SA02 Characterization: Biofilm Activity

[0129] AP-SA02 characterization: biofilm compatibility. Biofilms formed by several different S. aureus clinical isolates were treated for 5 hours with AP-SA02. The remaining biofilm biomass was stained with crystal violet and quantified (FIG. 4). NRS100 is not infected by any of the component phages of AP-SA02 and serves as a negative control. The extent of biofilm eradication achieved with one concentration of AP-SA02 ranged between 60%-90%. These data show that AP-SA02 can penetrate pre-existing biofilms and decrease attached biomass.

Example 4: AP-SA02 Characterization: Compatibility with Current Anti-Staphylococcal Therapies

[0130] Standard therapy for subjects with a S. aureus infection includes vancomycin and daptomycin. Since subjects who receive AP-SA02 are likely to be on these therapies, the effect of AP-SA02 on these antibiotics and vice versa was assessed. Using the standard checkerboard assay, the minimum inhibitory concentration of each antimicrobial alone or in combination with each other, was used to calculate whether two antimicrobials are synergistic, antagonistic, or indifferent (Table 3). AP-SA02 showed additive, indifferent, or synergistic effects in combination with vancomycin in killing all S. aureus strains tested. No antagonistic effects of AP-SA02 in combination with vancomycin were noted. Several strains resistant to vancomycin were also tested (MIC of >16 .mu.g/mL). While vancomycin does not have an antimicrobial effect on these strains, less than 1 pg/mL of phage was able to inhibit growth (FIGS. 5A and B). It was observed that in the presence of phage, the breakpoint for vancomycin changed from resistant or intermediate to the sensitive range (0.5-2 .mu.g/mL) (FIGS. 6A and B). In addition, these data indicate that vancomycin and AP-SA02 act synergistically since addition of AP-SA02 at subinhibitory concentration (100 pg/mL) to a subinhibitory concentration of vancomycin (2 .mu.g/mL) results in complete inhibitions of SA growth. Inhibition of VRSA can also be achieved with AP-SA02 alone at a higher concentration (10 ng/mL). AP-SA02 clinical candidate demonstrates robust activity against both MRSA and VRSA strains and maintains its activity in the presence of current standard anti-staphylococcal therapy.

TABLE-US-00003 TABLE 3 Vancomycin Daptomycin S. aureus FIC value S. aureus FIC value HFH-29753 1.01 HFH-29753 1.00 F339777 1.01 F336222 1.00 NRS35 2.00 NRS35 1.00 NRS696 1.10 NRS696 1.00 HIP13170 0.07 HIP13170 1.00 NRS719 1.01 NRS719 1.00 NRS698 1.01 NRS698 1.01 NRS706 0.51 NRS706 1.10 NRS713 1.01 NRS713 1.01 HIP15178 1.00 HFH 30364 1.00

Example 5: Manufacturing of AP-SA02

[0131] AP-SA02 manufacturing includes phage and host bacteria selection, and increased robustness in the purification process. Additional information and protocols for bacteriophage growth and manufacturing can be found in for example, PCT/US19/12113 (WO 2019/136108), PCT/US19/12114 (WO 2019/136109), PCT/GB17/50376 (WO 2019/136109), and U.S. Pat. No. 10,517,908, each of which is incorporated herein by reference in its entirety for everything disclosed therein.

[0132] All processes are conducted under cGMP conditions including manufacturing, product storage, Quality Control (QC) raw materials, analytical and stability testing, and product release by Quality Assurance (QA). Bacterial fermentation, filtration and chromatography are performed in ISO 8 certified cleanrooms. Aseptic filling is performed in an ISO 5 certified isolator located within an ISO 7 certified cleanroom. QC analytical and stability testing are performed in a controlled environment. Where possible, single-use disposable parts (filters, tubing, vessels, etc.) are used to reduce the risk of contamination during the manufacturing process.

[0133] All publications mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described methods and system of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the present invention. Although the present invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in biochemistry and biotechnology or related fields are intended to be within the scope of the claims.

Sequence CWU 1

1

21144299DNABacteriophage ARSA0001 1ctwcatagtg tataaatagt taggtwtcta actgttagat acctaactat ttatttttat 60atagttttaa ctactgtgaa ctatgcttat gtagtattaa actatgctga ttatatgcta 120aactattcta atgtatagtt aaactaagct gaagtagtat ttactgtgta taaaggtata 180tttagtatta gatattgtgt atatggtata ctataattct gaacattact tatttaatat 240atatatatag tttgtttcta tggtagtatt gacttaattt tccctagagt aaaagtttaa 300tatatttagt aatttccgaa caataaagaa attttaacta ttttacacat atgtgttgac 360agtatattac ttatggttta tactaagtat ataaagttaa aggagatgat ttatcatgaa 420gattaaaaga gaagtttcgt ttatagaatt aatgtatatg tattataaag gtgatgtagg 480taaaggtcag tactattcta ctaatagtca gtttattgtt gttataactg ttgatgatat 540atcgttttat aatgcattgt accctaataa atctattact attactatac ctaatgacac 600taagtttatt gtagaagcgg ttatagatgc ttctactgag ttaagtagta tagtagttac 660ttataagcaa ggtaacagtg tattaaactc agtatggtat aggattagta ttaatgaagt 720tattgactac tatgtcgaag gtaaaaatac atggttacta tctgttagta ctgttgtaga 780taatgagtta gttactatat ggaaagatgg taacgtattg tgatttggta tatagtaata 840ttcagtatac ttatatatgt acatcacttg tattattatg tgtagtacta gtatatagag 900gggttaaata accgcttcaa taaagactta gtaacgagga gttgtattat gagtttatca 960gatatttatg tacatttaaa tcagttagga tataaaatag aagttttagg ggacatgagt 1020acattaaaag ttaatgacta ctacatcgaa aatagatgta tagatagtgg ttttagggtt 1080acaggggata atgtattttt atctgtatat tatggtgaag acgtagtaag attctttaaa 1140caaaggttat taaaatagta ttttgttaag ttatacttga gaataattat aaaggaggga 1200ttagtttatg agtatattta taagtatagt ttctatattt ttagctacta ttagtattgt 1260actaagtata aggtttggta agaagtatta taagcatgta cttgataatt atgatagtgt 1320tagtgattta gaatcagcta gtgtatttgg tttattattt atgagtattt gtattggtac 1380tatttctatt gttttgagtt taggttacat agtaagtaga gtattttatt atataggagg 1440gttgtagatg atgagttcaa ctttaatgta tattgcggtt agtattttag gtattagtat 1500tatagttggt atgcttagtg ctttaattac tgatatagtt aaatctatta agcagaaaga 1560agtgtttttt agtatatatc ttattgtttc ttttgtttta actgttttag tttttgcttc 1620tataatacta catatgttag gtatgtaata gaaagagggt attagtatag gttactttgt 1680agtaagttta tcattaatgt atttagttat agatatagat atatgttata gaatatatag 1740taaagaaggt aatagtaata gatttaagtt agcagtgttt ttaactatac ttatattgat 1800tatgtttata tatggagtag gtgttttatt aacacaatag aaagaggctt attatggaag 1860aattagatat actagataga gtgttacata ataaatcagg tataggtgag tttacgtata 1920caaattgtat aagaacaagt gatgataagt atatttatag gttctttctg gaagatactt 1980attttggttg tgctattatg gtatatgatg atatgagtga gtatgaagta gtagtacaag 2040gtacaggtaa ggtgtatgtt tccttattga aagatgtagt tagtaatatg tataagatac 2100tagtagatga gtatgataag tatttaaaag atagtgcata tcaaaaatat atgtataata 2160tatttgaaga acaagtagaa cagtataact aaagtttttc tctagggaaa agcagtcaaa 2220ggtaaaaata gggcttgaac ccgcattcta tggttgacat ttaggtaaaa ttagataggt 2280tttccctaga agaaaagttt aaaaggtaaa aaaggagttg gttactatgt caaaattagc 2340taagttttgt aggaagtatg gagaagttac tggcataatg gagagtatta cagattatga 2400ggtgtactta ggtaggggtt ataaagtaag gtgtagagta ggtaatagcc ttatttatat 2460tcttgtatat aaagacaatc atatcattgc taggtttgag gaagcggata atatagtatt 2520tcctttgagt gatacgcttg aggtgggaac aattaaagac ttagaggagc tagaaggttt 2580gtatactaat atctatatat tactagggta tttatataca gaatatgaaa ataaagttat 2640gtatgaatat gggaggttag aataatggat attatggtaa gtgaattatt tgagtatata 2700ttaggtcata acactcacat tcttgggaat tggcatactt attacttaga taaaggttac 2760tgtattaaag ttaatgatga taaacattat aataacatga agtttatcaa aaatggtaga 2820gtagtaaaag aggttattaa cagtgacacc ttactaccta aaggattcag tagtatctat 2880agtcttattg attactatga ggaagcttta gatgaaaagt gcagaaaaga aaaagagcgt 2940ctgaaagaaa ttcgtacgtt cctaggtaag taagtattat atataaccgc ttctatatga 3000aactttatac ctatagctat tataactata ggtatttttt tatatttctt acataaatgt 3060gttgatttta tgtgtgttaa ggtttatact taatatataa ttaaaggagt gaatataata 3120tggatatgaa caaggaagta ttagaatgat tagatagttt aggtggtaag ttagaacaag 3180caggtacaca tagttatgaa tctttaatta aatacacaat tactcaaggt attatagatt 3240tatgttcaat aagtatatta ttatctataa cagctatctt atgggtggct ttgtataagt 3300cagataaaaa gtctaatgaa ggtcatagta ccctattatt tgagtttgtt tataagaatg 3360aaaaagagct ttctgctgca ggatgcacag taattatatt tgctgttact ctgtctatta 3420tttctttttt agtgctatta ataggcttgc ctattgctat tcaagagatt tttaatccag 3480aaggatattt gattaagagt acgatagata atttaaaata attgtaaaaa taaggaggaa 3540aatataatgt tagaacaagc taaaggcata actacagatt atattatgga atttattgat 3600gaacatgagc attatttcta tgaagactta cacaagttag caggggagtt agtgttgaaa 3660gatacacatg acacaaaccc tattgttatt aatgatggtg atggttactc aggtactatt 3720atatctaaat ttaaatcaaa ggtagagggt gttccagata tcactgttag tgatttttac 3780ggttcatgtt ctttctgtga tactttagct aatatctatg aaggtagtga tgaacttgag 3840ataattagag atttagctac tatggtacta catacaattc aatctatgga agagaaagta 3900gaataatgta taagggagtg atatagtgtt tagtaagaga aaagaaatta aagagtataa 3960gaaacaaggt tactctgttg attatatggg tggtttttta ggattatttg gtcttggcga 4020tgttttatac tatgtagaaa ctaataagaa atacttaaag tcaattagcg taggtaaaga 4080tgacaaccaa tatgtatatg actttaatgg ttatgaatac ttatcaagac ataagttaaa 4140tatcaaagaa gaagaactaa tgtctaaagc tattgctcag ttaagtatca aaggtttaaa 4200gaattttaat ggagttaagc atatttggga tgtaggtttc ttagagcaat cttttaatat 4260acatcgtaaa gatattgata cggttaaact taaactaagt tttgatgaag agggtaacct 4320atattatgaa ttagaattag gttggattaa tatttataaa gagtatacag gtgtaaaaga 4380ctttcttaat acagtagata actatctcaa cttcttctat aaagatatag tcactagtgg 4440tcttgagtta aaacaagtac tatataatac ttttatggga ggagattatg agtttgtagt 4500atctccatat aatgttgtag tatataggga agttgagtta attgatataa agaaatttta 4560ctctgatact tatggaattt attcctatgg ttatggcact aatgtacata aacctttaca 4620aacaattaag tattatctgg aataccctat gaatgaagta taaccacttc aaatattata 4680taaaaggagt gcttaatatg agtaacggaa aagtagcgtt aattggtagt aaggtattag 4740aagattataa tatttataca atcatgagtg agaaacatat atacttaaga gatagtgttg 4800atgtgacttt taatgatggg aaggtattac ctatatacat tgatagtgta ttaaaacaat 4860taagtaaaga tgataaaaat ctatattttt ctgaagaaga tatagatatt agtaaactta 4920ctaatgacga gtattataca gttactaaaa aataaaagga gaatagataa tgagtagtaa 4980taaaaaaata gcagaaagag ttattgagaa atttttagat gagactaata aaggtgtaga 5040ttttactaat caagatgaat ttaaccgctt cttagataat acagaagact tgtatgaagt 5100atctggtact caaagagata agattattaa gtgtttacaa aacattgtag ttactgtatt 5160tatggataag gggaaataac aatgaaaaca ataaaaagaa aaatagtaca agaaggtatg 5220aacaaagaag aaactatgat ggaagacgat tctgttgtaa taaaaaaaat tcaaaaaata 5280acaggcggag ctattcttcc tttagccaat ggcaaggaat atgtagtagt gtttagtaaa 5340gtagacccta ctaaattaat tgtatttaat gtggaacgta atcaaatcta tttaagtggt 5400tctggtttcg atagtgaact gtcttatgta gacagtaaaa gcaaccctat taccttagaa 5460acagttaggt taatcactaa tttattataa aggttattag gcttttaaag attaagttat 5520tttatagaat aaatactact agaaaatgat tactgtttaa tacagaattt taacgtacct 5580agcttaaggg tattaaatat aaaggagggt attagaatga ctaaagttgt aagtagagga 5640tatagttttg aagaacaaga agtaagtatg aactataatc aaggacaatg ggtgatttat 5700gcaagtagaa aaccttatat tactgatatt atgaaaaagt accctgataa ggtggaagta 5760ttagaacaat tagaaaatga aacaccagta ttggttaaag ttgtattgga tgaagattta 5820attacattga gaaagccaat aagtaacgag cgtaaagaac aaatgaaaaa gattgctaaa 5880gaaagatttg gtaaataata gagaggctga ctttaatgaa catcagtatg tacactaaca 5940cctgtaggga ctagattaat attacaagat atcttatagg gttatagtgt cattgagaat 6000gagtatgctt tattaaggtt agttaaagaa gataaacagt atttataata tcatattgaa 6060gaagtagaag cggtattaaa ccgcttcttt tttatattat atttatattc tgagtaatta 6120tgttgtattt aatcttggct aataattgta tatcaatttg agcatagtat gcccgtttca 6180acatagttaa tctaataatt tgtatattta tctgttagtt atgtataaat atttgttatt 6240acttatttat atatttgtat ttcgtactaa ccgtacgact tatcttttta aaaagataag 6300aacaaaacag cgtatacctt gttgttttac gctacgctac aacaaggtaa cgcctgtaat 6360aagttattcg tattaaaata ctaacaacta attacttgtt gtttagatta taacatatgt 6420ttatgagaat tagatgagaa tttagttaca acagcattat aataatatta cagttatgtt 6480acaagttgct aagtatgttt tgttactaca atatattgaa tatgaaagct ttagaccttt 6540tctgcagaca agtaattatt acaggtatgt atgataaaag ataagtatca gggattaaat 6600taaggttgga ttaatgaagc ggataagtta gatactggtt aaaataaaat actttacatt 6660acctaaaact tatgatacac ttaggatagg ataaaggagg aatatcaatg aatattcaag 6720aagcaaagga taaattatac gatgaattac tttatacagt aagtctttgt gagggaacag 6780aagaagattt actagaactt attgagaatt tattttatat ttacaatgac gagcctgcat 6840ttttaagtaa agacggtatg caatatacta ttaaagattt tatggagaga agaaaaacat 6900tagaacctat cttaactgaa ttaggtatag ggtacgcaat gatagaatat cacacacata 6960cagaatacga gttagttact tattcagtac ttaaagttat acagtatgat gtagataact 7020atactgtaat tattgatact aatagtgata agaatattaa gttatcagat ttaacattag 7080aagctgttaa ggatattttg aatcaaatta agtagctagg gttgttttac tctagctttt 7140tcatatgctt gtgttgccta tttaactacc ttatataagc aagtaagtat tataggataa 7200atactaccta aaaagtatta ccgttgaata tagacctata agcttaatgc tctcttactg 7260ttataaacat cataagtata aatctatgat tttcctaagt agcaggcgct gttttccctt 7320tatattaacc gcttcaaaca acataaaaaa agattaggtt aatagcctaa tctataactc 7380ttttatataa ttcttgtaat tctttttcta acttttttat tgtttctata tcattatttc 7440ttttaataga ctgacatata aatgcaatac ctttaatcaa attaaatggt tagttttaca 7500ctgcattgta tacaattaaa tcgatcgatt ataataatta atttaatctg tactttctag 7560tttcttctat ataatagtaa gaaatcattt cttttgaaaa actttcgtat aacctattga 7620cattaaatct aggatagtgt aatgtaataa gcgtagtaaa caaaccgaaa ggaattgata 7680agatatgaac gtaaatcaaa ttggagatat actaatggaa ttattagata tagatggtta 7740caaaagcaat aactactata gaaatgactt aaaatactca acacattatc aagttaaata 7800tttagcttac attgatggta gttatgaaac attagaacta tttaaagaaa cgaaagtctt 7860tagcgtatca cattcaaata gattaccaat taacattaat gttaaggtag tgaacaaaca 7920cttatttata gagctagata atacgttata cctagtgaat gagaatgcag aaattattaa 7980agaaaaaaag ttaaaataat agttgacact atcattaaga tagtgtaata taatagatgt 8040agtaaacaaa cagaaaagga attgattaat tatgaaaaca ctaattacta acagtaaacc 8100atataagaac tacggctatg aaatggaaca attcgagaga gaaaacaacg taattatcac 8160acgagcatac cacgaaccaa caaagcaagg ttatagtctt gtaatacact atacggaggt 8220taaataatat gaaatattta tattacatta aaggaactta taacagaatt aaagcacaag 8280gtacaatatc aaatgactat agattatggt caggtattga tgaatgtgat gacttatact 8340accatattaa taaagcttgt catagtcttt ataataatgg tgtaaaggaa attacagtta 8400cagacaaatg cgttaaacta acacttaata ataataaaac aaaacttatt aaaaaagttt 8460aagaaaagtg ttgacactta ctaaaataca tggtaatata taaatataaa gaaaacacaa 8520taaacgaaaa ggattgatta attatgaaaa acacagtaaa agaaatggca aacggaaaca 8580ctaaacttga aagattatta gttttagcaa ttgaggaagc ggttatgaca gagcttgttg 8640aatatgatgc attagataaa tacaaccact tagaacaaca gttattaaac aatgaagcat 8700taacacaagc agaacgtaaa ccatctaaca ttgattatag cacttacgag ggagctatat 8760tagcacaaga caaagcagaa cactttacta acgttatctt aaaccacatg aacaaagaac 8820aatttgaaca aatgattatg gatattgaaa cactagaatt taatgcagaa caaatgctat 8880tctaaggaga cattacacat gaacttatct gataaagaac ttatagatat aatggacaac 8940gttaatagct tcactgatat cagtgaagct attaacgaaa cagtaagcaa acaaacaatt 9000aaaggcagtg acaaagacag cggaacgatt aaacagtaca atagtttaga tgagttaaga 9060caagactatg acataacaac actagcacca gacgtaataa aagaattact gaataatcat 9120tagtgtaaaa cttcccaaaa taattaacta aaactattgc aattaactgt atatttgata 9180taatgtaatt aaggaaatac aaataaaaga aaagggattg ataaactatg aaattactta 9240accaaatgga acaaacagca gaacttgaag gaattgaatt tgacttatta ctaacagcta 9300tctatgaaac aatagaggta gatgttgctg aacacgattt actatgcaaa tacattcata 9360ttgtaaacca attaaaagag aataaagaca taacaccatt agaatatata ccgtctaacc 9420tagactttac agacgataca acaataagac tagttgataa taaagtgttt gagttagcag 9480attatatatt ggaacatatg cgtgttgaag agtttaataa acacattaaa gactatgaac 9540aaattaaagc agaagctata gaaatgatgt aaaacaaatt gaaagggaat aaactccctt 9600tctttttttt tattatttat taggattgta tacaataggt taatataaat atattatacg 9660ggggcagggg taaaatgcca ctaaagtggg tgggtctgac agggctatgg ggctacctaa 9720ggaacctaat tagtgagtaa tattatataa cttattatta aaagtcaaca ttaaccatta 9780ctttattaaa ctaggtcaac attactaata actaattgta ttcattttac aataaagtta 9840gtaatatatc cccctcttcc cttacactta attagagtat tagtatatta cagcatataa 9900gtagtttagt atataggagc ctttccttat atatagtttt ctatggtatt ctttagtata 9960ccattttaat aactagttat actatgtact attagtagtg agtaatatta tataacttat 10020tattaaaagt caacattata aagtatataa taataaaaag tcaacatagt tttattattg 10080ttattaaagt aaacatggta agatttcttt tactgttatt attgtcctgt ctatctctac 10140tgcctttact attatagtag tagtgttact ctatttctta caatataaaa aacacctaaa 10200ttaataggta tttaatgtga catatcatat ctatattcaa ataattctct atctacttgt 10260tcgaaacctt tctttttatc ttttataata tagttaccat gtaaaacttt ttcaatacct 10320gaaggtgcat taataaacag gctattgttt ccttgtttgt ctactgctct aaatgtctga 10380ccttctgtcc actgattgat gtcattctta ttatagcctg tatattgaat atattctact 10440acgtattcca tgtcaattaa gacttttagc atatactctc ttactttagc ataatcatct 10500gtaagggtat ctaagtctag aggttttact tttgctatat tgcttatact acgttctttt 10560acaggtgttt ttgcatattc taccattaaa tcaaataact cactatctgt gcctaagctt 10620cgaaaagaat atggttcatt tagaaatacc caagcaatag gttgttggtt ttctttttta 10680ataagtattt tttcttttct cttggtagta tttttatttg cgaggctggt ttcatatcct 10740aactgattta ccttcttaat aaattcattt gtatacattt tttaatacct ccttatttat 10800tgtccacgat ttctatttca tgtattgtaa tcatgtcatc tctaaaatca tctatatgtt 10860taaggtaaac aataccatca tgatttctag acatgccttg taattctttg tatccttcag 10920atttaatgtc tttaataagc tgttcttgac tagtatatat tttatcttct ctataagagt 10980agctgtcttc gtatagctca caattatcat gctctacttg gtaatatttc attctttttt 11040actccttttt tcatagatat ttcctacaac ttcagtatta ccaatctctg aaatgcacat 11100catagagaat ggtatgtaat ctcccccttc aacccatcca aaagaagctt ctttaaatat 11160tacaggtcta caatcccccc aatatctaag tatatcacct tcaaatattt cagtaccatt 11220cttatcttca agtcctgtag attgcataat tacaaggttt tctcctaagt aaccatcaca 11280agcaaatagg tgtgaatata ctgtatggtc tgcaaagtca aatctagcaa tattaaacat 11340tctttgtgat tctttatccc atgctctaaa tttcggtatc attctattac ctccaataaa 11400tgagatgatt caaatacgtt gcctttaacc tcacagtcgt acataaggaa agattttttg 11460tctgtatact caaagtaatc attttcagag attgcgctct caaacataaa gtcttttaag 11520tgaatgccac ttacaacatc aatagatatc actgctctgt taattgtttc tactgcagat 11580tcaaaatcac ctggtattgc taacacttca tcttcgaact caataatatc accctcatat 11640attttagtac cgtttttgtc tttaagtcct gtgtattgta gtaactgtat atccttagaa 11700aaaataaaat taccaccttc taacattatt ttctcatctt ttttccatgc tctaaaccta 11760agtgtcatac tgctaccttc actttttcga cccctatgct tgcagttttg aatgggagtt 11820ttttacgagt cagttttaat gtcctatttt tggcttcttc ctcattcgta ctttgcacaa 11880aataatgctt ttttatttta taatcacatt taaacgctaa gaacttaata caaagactca 11940ctttataggt ttgcatcatt ctaccaactc cccatctttc cagattaacg tcatagttag 12000gtcatcgttt aagatgtaga atgctttggt aggcacacat ctgccatata aacattcttt 12060tatactagtg ttctcatata gtgtagagtt atagtctcct tcttgaatct cgaataattc 12120aatcaaccta tcaaccttag cctcttctgt gatttcctct tcagcttcga cttcaaaagt 12180gtcgtcagct gatataaatt cactaacaag acattttctt ccgtcttccg aagaaaaata 12240aacaaagttc tcattatctt gattttctgt gtaaattctc tttccttttg ttaaatcagg 12300atattcccaa gcccattcca tgagttcggc tagcgtcatt acttttttag tttttatttt 12360catttctata tctcctaatt atttaatttt tctatcattt tcacaatctc ttttgatttt 12420ctaatgtcag cattttcaca gttttttaat atgaagttaa ttttgttttt tacatcatta 12480acgatactgt ctacttcttt ttctgttggc ttagtaggga aaagcaaccc tacaactacc 12540tgaatttgat ttttatttag tgagtaaaca ctaatgttac atttctcatt aaagtcaata 12600tgtggtttac ttgaattaaa tacctcatct acaattgtat ttaattcttg tataggttta 12660aaataatgtt gttttctttg tattattacc tgtgacatta gtttatatag tttctgttct 12720ttatcaagaa cttcttttgt aagcctttta acttctccta tccttatagt attaccccat 12780gcatcataat tatttttaac atactcagct tcttctatgt tagtagtata tcctattact 12840tttgaggtgg gttcctcatc ataataacag tcctcttcta catatatagc atatatctta 12900ttcatatcta tcaaaccttt ctttaagtta aattaactat aacatataaa cattaggatg 12960tcaactacta atatacactt ttttcagtaa gcaaaaaaaa agaacctttt tacaggttct 13020ttactgggtt attaattttt taaatcttgg tttcctttta ttaatttttt atcatcaata 13080ggatgaccat tgtataaata ttttacttcc atatatacat gattatccgt agccgtaagg 13140gcatctagga tatccggatt tgtgttaatt gcatttgtat caggaaacga aaattttctt 13200ttatccgact ggattatatc tacatgaaat ttttcttgtt ttggtaaagc gtaattaagg 13260tcttctaaat tttgtaagaa tttagtaaga gaaaagggtt taaactttcc ttgtaaatta 13320ttatctatat agtcatttaa tagtcttgtc atttcctctt tatttaaagt cattgtttca 13380taatcgttaa catcataaaa aacaacaaca ttaggttgct caatacttgt gtctccatct 13440ttgtacttag caatgtaata gcctatttca cctttgtgag ctaaataatc ttctttcatg 13500atattaaata cttctctagc aataggtttt gtatatagtt cttcccattt atttgtttct 13560gtgttgtaaa aatgtggtaa taagtttgcc attctgagtt atcctttctt attctgattt 13620aagccatatc ttattagtat ttttaggcgg ttcattactt attgtgtatc catcagtacc 13680catatctagt gtgtttacaa tgacaggctg agctacagct tctttttcac tctctaatgt 13740tttgaaacta ggcacgtctg ttttattaga ttcttgtcca tcgactaacc aagagacttt 13800aaagtcacct ttattataag tagtattagg ttttaaatct gttaatgtta cttttacaga 13860actacctgta acttcatcag aagttaaaat aagctgttcc tctttgttgt agacctttaa 13920ttttttagac ataatgttat ccctttctgt tgtgtaatac actaataata taacatataa 13980aaaacaggta aggtctttca aaacctttac ctgcttattc tttactgata atcataccaa 14040tcaagaaaat catctgaaca gcttaactct atagttatat catttataag tttagtagct 14100tcatctttac ttaatgactc tatatcaaaa gtaaactcat catataaaca atctatatgc 14160ttataaataa aatctttttg tttttccgta gctttgttta attcattgct ttttttactt 14220ataaattgac taaagttatc actcatttaa atcttcctct ttaataaagg taccattaac 14280tgttcttcct ttacgacctt taatttcatt ataagcaaac tctaaacact cttgtaatga 14340catgtcgtgt tgctgagcta aaataattaa agtaactaca gtgtccccaa taccatcttt 14400aagagcttct aggttaccac gtgataatgc cgatgctact tcacctgctt cttcgtagaa 14460tttaagagct tgtctatcag ggttgttatt gttcaatcct ttatctttac tccattcctc 14520tacttgacta actaaacctt ctagcgtgcg gtcttctgtt tcaccttcat taaagttagg 14580tttttcatcg tttggtatat ggtcttcttg ttctctatcc tctattgtaa taaataaagt 14640gtctatttct ttttcgtact tatttctctg catataatta tactgctcat actcaggata 14700aggtacatat acagtatcgt ctgtaccatc ctcataattc aaacaaacac aaacaatatc 14760tttgccactt agtctatcat ataatgtcat gttgtagggc tcatctaaga aaccatgaaa 14820ctcttcaaag tattcatcct tcataccact tacctcaata gaaacttttt ttgctgattt 14880acttgtatct acttcactat ttccatatat catagttttt tcttcactaa tgccttctag 14940tatcaactct acattttctg gttctaacat tgcgctatct aagttttcaa aaacaatttc 15000aatattttta atttttttag tcattaataa

tcattccttt tttttagtat atagtaaata 15060taacacataa gtaaatagaa gtcaataaaa agacacctac tttaaaaata agtaggtgta 15120agatattttg acaggtagct tgtggaaaaa aatcctgaga gaggactcga accccaacga 15180ctaggtagct acaactagcc aataccatta ctcaggattg atagtaacgc taaatagagt 15240cataacgtta ccatagacct tttctacgct tggtatatag gtagaatata atgattttac 15300agtacccata tagttagact gttactctca ttataaggtt aaaaaatgct aactttgttt 15360cgcattgtca agaggcgtta gttaactact ataataatat agcatatatt ttattgtttg 15420tcaagttctt tattccattt acttttttct tttagtaatc cttttttaat tagttcttca 15480ctaatatttt tatactcttt attttctttg tagaaaactt tagctaaata tctaccaaaa 15540gaatcatctt tgtatgtttg aattaaaaca tcttttcctt ctagcatagt tgttgtaaat 15600tccttagctt cttggtaatt attttgtttc ttttctggtg tgtcgacacc tagtaatctt 15660attctttgct cagaatatgt tctcattccg tggtcaatag ttacatgtat agtatctcca 15720tccactactt tgtccacatg tgctttaaat aaatataaat tgtcttctat catcattaaa 15780tccccttttt actaatttaa aattatccaa tcagtattgc ttgatgtacc cttaactaca 15840tatacagatg aacctattat agcaatttga cctttattta cagatatcat ttagatgaat 15900atggtcttgt actgaaaagt ctacaatgac atgtttatgc tttttctttt ttgttaatac 15960tttatatgtg ataaagaatg atataatagt taaacatata tttaattttt tcataaaatt 16020tctcctttaa agaaggtatt taccatctca gtagttaatt ctttgctttt aaagatacaa 16080tattctgtat ttttattcaa tatttctaac atattttgca tactacttgc tttttgtaaa 16140tccgttaagt ctataacaac tgttatttct gcgttatcta ttagaatatt acctatgtaa 16200taatttttaa ctccattctc cgtagcatga gaggtaacat tatgatttaa aacaactata 16260ccttttgatg gtaagtactc tgaaaagtat aagtaacaaa agtatttgtg tatctttttt 16320ttattctctt ccattactat taccatattc tatgaagttt aatagccttt cggtataggt 16380tttaattttc tctacttctt ttctttcatc gtcttttctt cctaatcttg ttgtatattt 16440aacaatatta aatagcatgc agtctataaa gccaataatg tagaaatatt cttctaaaaa 16500tgatataaca tcttttttac ctttataatg gttcggtgta ttagtggtag aattgacatt 16560atagtataac tccagttgtt ctacattttt cataagcttt ttagcataat ataatgtgtc 16620atctaaagaa tgtgtcacat ctaaagatgc ttcaacaatg tttatcttta attcttttaa 16680ttctgttgcc tctttgttac ttccaatttg tgaatcaata aattctctag tatccatatt 16740ggtgtccttt cgtatctaaa ataaaaaccc tatctagaat atagataggg aaaaggaaag 16800atattatgga agtgtactat aaagtacaca tataatataa cagttccttt gccttttaat 16860ctatatcatt tattttaact tcttgtactt taacataatc tgataaacta ttaacgacga 16920tattatcttc tactaattcg tttctattat ttgtaacatc atatgagtct ctataaggtg 16980tttgtactaa tgctctaact gtaatgtcta tatctacata ttctttacta tacctttcca 17040ttactcaacg tagtttcctt tagcaagctg atactttttg tgtaattctt catataattt 17100ctccatatct ttatattttc gtacatcttc ttcaaaatga cttaaatact ctattaatgt 17160cttaacttct ttaggttcta aagttataac tggttttacc attacgcaac atcctcacta 17220aattgtttat ttatattttt aatatctttt attaattcgt cttttaattc tttaggtaac 17280tcatgacttt ttaaagattg ttgttgacct aacgtatatc catattttgt tatccttact 17340tctacagtat accatgattt ttctaaatcg tcaacttttc tagctagtaa tattaaacat 17400ctgtcattta taatattcga agcataactg ccgacacaat gagatagctg ttcaccttct 17460ctttttaatt tttcagtagt atccgcaggt aaaaatttaa ctttagagcc atcgtttaac 17520ttatattctt tatttgtgat attatttaat ttattatcat atttttgttg taactttaag 17580tcatcgactt catctttaac tgttaaatac tcatcagtaa caatatcatg ctctagtttt 17640aaagaatatg gtgttaagtt aatactttct ttagttctat atccaagaag tactaggtct 17700gaagcaaagt ctatataatc tctatataaa ttattaacag cgtatgaatg tatacgttgt 17760ctgtttctga catcatagtt tatataattc accatttttc taaagtcaga aaatgaaaag 17820ttaagaactt ctttcgtagt acctttaaaa gataaagcat ttcctattga atatgaatta 17880gtcaccatta taaagtcgtc atcgaatagt ttgtgtaagt tagactcatt atataaacta 17940ggaaatttat ttatgataac tcgaagtata ttaaggtaat tttcttgctc ttctttacta 18000agagtaataa acttattata tgtttgttta cttaaattta aagcttcatg taatttccat 18060ttatttttgt ttggtattac tagaaactct ttgtgttctt taaatatatc acaatcttcg 18120ttgttataaa ctttatcaat attagacaca actaatttta acatattgtt taaattatca 18180gtagcatttt cacctttact aactgtgcga taaccatcag gtctatctat catagagtat 18240acatcaaagt tttttacatt aagtctactt agatttaagt aataatcatt attctttagt 18300gtttggatta ttatgttaaa agctaaattt tcctttccat atttacttaa aataatattt 18360aaaaggacag gtaaagtaat gttatttttt agtttatcct tattaaaatc atcttcatac 18420atattaaatt taaattcttt atgttgtagt gtatttgata ggtgtaggta tacatttcca 18480tttttattat taaagtcacc gtttactata ctccaatctg ttgttactat acttatgtct 18540tttaaataac aagtcttaat taaaaacgga gtattattat cttttatagg tgttaatttg 18600ttaagcccta tttttatgtt ttttaaaact tcattgtagt attcgtagtt attatcataa 18660gatttaccaa atgcataagg gtcaatatta ataccaaata tactatagtc acccattaat 18720aatacatcaa gtatatcatt agttgtagta tttatttgtc tttttaagtc tcttattttt 18780tttgtaaggt aattattact attcttattt tgcgtattgt caaactgttt tagttcattt 18840tcatagtttg cacggcagta tatattatta cgatagtgtc ttttgttata taaaggaaat 18900tcagacctat cgtcactttc tatatactca ctatatacag tatttacatc tgtaactgtt 18960ttacttaact cttgtacttt tttatatggg tctcccttaa acgtagtaag ttttttattt 19020ccacataatg ctataaataa aagtaaattt aaagcgctag aataacaaaa ggtattatta 19080atatctctta ataattcttt agagccaata tctacaatat ttttattatt tatttttaaa 19140tatactcttt cttcacctat aaatatacta tttctattta ctttagacaa tttaagaatt 19200tcttcttccg ttaatcctgt ttctttatat tctactgaca tgtgtcatca cctcatttat 19260tattatataa gtatgataac atagttaaat ttaatagtca acaaaaaaga agaacttttt 19320tacagttctt ctagataagt ttcatattta atttttttag ttcttcttac gggtacaata 19380tcgggattac tcattaagtc tttgtacttc ttagaatttt taaagttaat agtattaggc 19440attgctaaaa cttcctctaa ctcatctgtg tacatagtaa ctttagatat tatatctatg 19500tcactaatat ataaattttt agatttactt ttaaaaataa tctcatcggt actagttact 19560tctttattat ctattaaatc catatagaag tcctttctag tctacataaa caagtataca 19620atctttgtct gataaagaca ccgaggtcat atcattaagt tcttgtagtt gtttaataga 19680cacatcatat ttcttactta tagtccataa ggtatcacca tttctaacct tataataaaa 19740tttattacct ttttgtatta agtctttcat tgttatctac gcctttatat tcataataag 19800atgcctgtag gtaacatatc gtaataagaa taaagttagc tacttctgta tatattacat 19860gtggtgtcgt atttgttatt aacatactaa taattaaaca agctaatgca atacctataa 19920taagaaataa atatttgcta gttccatttg tacttttagt tttataaaat ttatttattt 19980gggataaata agctacgata atactaatag tagccattat ctgtccatat tcaacactat 20040agttagctac tgaatagcca atataaataa caattataaa cataaccatt tctaaaatac 20100taacttctgt tgttctaaat aagtatataa taaaacaaat aatacctagt aataaattaa 20160tacttactga tataatttga aataggggtg catgtgttac aaataagctt gttaagctaa 20220tacttactgt aacaacaata taaaaccaaa aatagctatc tacaccttta acattcttat 20280ctcttatcaa acctactaaa gcaggtatat atcctacagt aactaatata gcatatagga 20340tgcttaatat atgagctaaa ttattcatat gaccctccga aattctctat ctcatttaaa 20400acttcttccc atgaaataaa acctttaccg ttggttaatg ataaaatgtg cttggtaaga 20460ttattccatg ttttattatt tttaatattt gtaattgtag tataagtaac tttaaatttt 20520ttagataaag tagatgcctt ctctttgctt gtgtaaatca agtagacatc atagtctgtt 20580aattttgaat ttataccaaa aatattgtcg ttccttagac tggtttttat tgcatgtaaa 20640gtgttctctc taggagtaac ccattctaag ttttcaactc tattatcatc ttttatccca 20700tttttatgat tcacttggtt tctatcaata tttttattta agtctagcaa aaagcattct 20760gctataatcc tgtgtacttt gcattgaata cgtttgttat tttctccaaa taacgttact 20820attatatacc catctttatc ttttcttgtc tttaatacat ttttacgctt acctttgatg 20880atacctgcta tacttataga atattctttt gcaaatggaa tagtagacca taaaagacca 20940tcttcaaaat aaatatttct aggagtgtat ttcaaagggt aatacttcat agaatctttg 21000tagcttctag gagaatagtt atatttttta aatatagttc tcagttccgt ataactaact 21060ccatactttg tagcaacttt cctcatactg agaccactct cataatctct tattgcatta 21120tcaatcttgc tgtcccaatc tttcaagttc taataatacc tcctcccacg aaatgaaacc 21180tttgccatcg gttaatgaca gaatcatacc aaaaataaac tggttcgttg aaaactccgc 21240tctgtctggg tcagtgtatg gttttccgtg cccttgacga atatcagagc aataaattaa 21300aacaggttta ttgacgacat gatacgcttc taatatatca tcttgtgtgt ttttatctaa 21360ctctctaaaa tctacatctt catatttgtt gataatttgt tgagcttggt gtttcattcc 21420taataaaata ctaagttctg ctattgtacc taatccctca ttcaatacat caaatacaaa 21480tatatctgac tcttgcatag ccttaaagtc attatttaga atacgctcag ccaaaccctc 21540ctgtctagca tttgctttgt cgttaattga gccatcttga tgaggagagt atggagatac 21600acctacaatt ccttctactt gattgtgttg tttttctcta tattctatca ttgcttgatt 21660aagtagatga cctcccatat agcaaatctt atctttgatt ttatttacca ttgtttttat 21720ctccttttta tttatttaaa agttacttta cccatttcca atacttgtat tctcttattt 21780ctctgattgt agttctattt acaccatact tttttgctaa ttctgtatga cttaaatcac 21840tcactcttac ttcttttatt ttttcttcat ttaacttaga aacagggttt tttcttttac 21900cacttatata agaattaagt ttatgctctg tattatactc attagtacac cactctagat 21960tagaagcata gttgttactt ttatcaaaat ccttatgatt gacttggggt aggttgtaag 22020ggtttaaaat aaaaacacta gcaactaatc tatgcactat ttgagtgtta ctcttatctg 22080agtagtttct taaagacaca atatgatacc cttttttgtt tatcgtatgt tttagtatct 22140ttttggtttt atcactgtat acatttcctt tttcgtttat ataataaccg tagaagttaa 22200ataaagggta aaataccttt ccatcaacat ttttaatatt taaaggctct tgatttctat 22260taacaaaacc atatttattt ttcttcttgt atgctgagta acaaccacaa cttctaatag 22320ttctattttt atactggtct tttcttacct ctactatatt accacactta cataagcatt 22380taacatattt acgctttcta tttttacatt gtttaaatag tgtttttatt gggattaacc 22440atgtttcttg taattccatc atacaactcc cttatatctt ataatttctc cttttctttt 22500tcaaactcat ctcttagtgt gatgatatct ttattaagtt catctgaatc tttcatttta 22560gcccaatagt aaaagtctct aagttcagga tttcttgcta aaatatattg cttaggtctt 22620acatctcttc cttgtgataa gaagtaagct atatctctca tatatttcca gtctttgtaa 22680tagtcagact tatatttaaa cataaatcct ttcaaatctt caaatacata cccttcatgc 22740aatatattat aagagccatt attatcctta taccatttat aaaattcttc ccaactagca 22800aactccaact ctttttcttt tagttgtaat cctacttcat cagcaacata tttcaaataa 22860tcataatctt tctttttcat atttaacgta tttgaaataa tatcgagtaa gaatatatcg 22920ctttttcgat attttatgat atgagggtct tcttcgatat caactacttc aaacactaaa 22980gtaaaactat cgtcagcaat ataatgattt tcaaggaatg ttgttaatgt ctgtatctgt 23040cttttagtta aagttttttc taccagctct ttaaataata atgcgtattt attcccatgt 23100ccacttaaat gtgtttttga tttacttgca tatacaattc cttctaacgg gtcatagaac 23160attaatccta aaaatccatt ttctttctta tatccagtta aagggaattg gatagtgtct 23220ggcatattct ctaatttggt ttcttctact tcattgatat taaagaactt attatatcct 23280cttcctaata ctgtatttct accttcatca atataaagac ctctagagct cactgttaat 23340tgattccatt tctttttaga aaaagctctt tttgtaaagt taactgagaa cacatctcta 23400tattgtttat tggttttgat gattttattt tcttttctag ctatatctaa gtattgatta 23460ggagtgaggt ctttgtcaat actatcattt cgtctgtttg ataaaaggaa tttagggtcg 23520tagacagtgt tttttatttc atgtttctca atgttgttgt ttttgtctat tgttactgct 23580cttaaacaac cacctttttc tacgcgccct tctaaattaa ttgatttttt attattattt 23640aaaggttctc tatataaatt tctataccca tgtatttgga ttacgtcaga atgttcccat 23700tggtcatcaa cattaaaatc atatcccccg attccattaa taagctgact tgttgaaatc 23760ttgtttaaat taccaagaac ttcaggaagg actccgccat gactaacaat atagtcctga 23820cctttaaaac taaagtaagc cacctgttgt aattttctaa gaatagactt tactctattt 23880tgagttattc cgttctctat gaaggatttc aaggtaggca taaatcctct tgcatgaaac 23940agatttagag catgtttata aaaataactt ttcccaaaat ccaccttttt gaaacttctt 24000tgataatttt ttcatcataa tatttctcct tatattccaa ttgctttttt tgctaatgca 24060tctacatatt cattccattt gttattatca tgagacttta cttttataaa atttatatct 24120ataaactttg agtattccct tagcatatta atatatgttt tacttaaatt gtttttagtt 24180ttccacgaac cttcatacca ttgaataagt cctatataat ctacatgaat aatagcctgc 24240ttataaccta gttttatagc ctcttcaata ccataacaac aagctagtat ttcacctgca 24300acattattat acttaattaa attactattt tcaataggtt tactgatttc ttttacaatg 24360ttctcatttt tatctaagat aatagctcct gctccaacaa gacctttatt ataagatgag 24420ctaccatctg tatatattaa tgcagtctta tgcatattta tgcctttcta caaagcaagg 24480gaacatctca cttgtataaa tctctttgta gtcttgtaat tttatagtag agaaatcaaa 24540aaacttataa caatgttctt ctgcttcgat atagtcatct gcaataacat taacttcaaa 24600accatcaact aaaataacga acaatttctt aaacatttaa aaaacccctt tataatttaa 24660taaggtactt aattaaatca atttcagtgt acttttctga gtgttctagc tcttctaatt 24720tttcttttac ttcttcaagt ctgtatgact cttctaaaag ttcaaactgc tctaataatg 24780tgatactatc aaattcacta ctattaataa tgttgtgtat atattctaga tgtgtgtctt 24840taataacgtt tgttaagtca tcaccagtat aataatcctc gatatacgat aggtctccta 24900ataactcagc cgtacttcta ataatactat atttagatat attagggtaa gattgatata 24960aacaattatc taatttatta cttaaatgct ctactacttt ttgcattgta ttaccttttt 25020cttcagtact atatgaaatt ctaatattag ggtttttaga atcataatca actaaagaac 25080tcctattagt gtttaataac ttatctaaag aagttaaaat aatagctcta tcttctatat 25140tatctaaggt taagatagta tctataatag tataaaatgc tttgtctcct attgctttat 25200taacatcttg aagttcaaaa atattaatca tatcctcaat ctcatgacgc tcaacaaagt 25260taataataga ttttgtaaat ttattcatca acgtcaacat ctttaaataa ttctacacta 25320ttagtattta aagctttttc taatttcata agattagcac tcttaggttt tcttttacca 25380ctctcccaat aagaaataag tgagtagtga actccaatct cttgtgctag acttctaact 25440gtatgacctt tttcttctct tacttttttt aaatttaata ctttattctc ttccataata 25500aaccactacc tatctttctt caatttttaa aatactatag ttatttttat tataagcata 25560cttatttaaa acgtcaagcg ttttttcttt agcctctact ttacctttag ctttcatatt 25620aacatagaaa acattacttt tatttgaacg tgtatgctta atatatactt tgtactgcgt 25680aacctcactt tttaatacat tacgtttaaa ccatttcttt aatttttcca tttattataa 25740ccacctttaa aacttatata tgtattgtag catatgataa atacattgtc aacttaaaaa 25800taaaaaaata ctagggaatt ttccctagta aattatttcc aattaatacg accccaatac 25860ttctctttta gcatacgttc ccacttgtca gtgattttac atactgccat atagaagttc 25920ccagctgacg ggtttgtagg atatttaaat ctaatccacc aatagccatc tgctttaata 25980acttggtcaa agtttacata ttgaccacta taaataaatg attcagctcc tacgattgaa 26040ccacttaaac ctggtgttcg tcttacctta atcgttctat cagcagtaaa tttacctctc 26100caattccaag ttgtttgtac ctcgtctttg aaattaggtt ctataaacca cataggaaag 26160tcgtaaccat gggctctaat agtagctttt tcccagccac cgcctccttg agcatctccc 26220caagtccaac ctccacctaa ccaattattt tcaattacta taatttggtt ttggtttgca 26280cttagtaccc atgcgacatg accatgacca cacccgtatg aattattaaa gataaccata 26340gtgcctggtt taggaatgta ggatagtgta ttttctacta ctctagcttt atcttttaac 26400atagctttat tatcccatgg aatattacat gcacttgctc cacctaaaga ataacctggg 26460aagagcttgt taaatccata gttagctaag tcgtaacatt gctgaccata ccaaccatca 26520aagtctattg ctttgccttc tagacttttt aaaaatcgaa caaattcact tctagtcatc 26580gatgctttca aaagttttca ctccttattt ccaatctatt tttccaaaat atttttcttt 26640cttaatacgc tcttgtttat ctgttatctc acatacagca caatagaaat aatttttact 26700agagcctggt tttggatatt taaatcgaat ccaccaatag ccatctgctt taataacttg 26760gtcaaactca acccaatcat ccttatcgta tagccatgaa tctctattta ctatagtgcc 26820tttaagtcct ggagattttc taactttaat agctctatct ggataaaaag tacctttcca 26880gctccacata gttttagtag attgtgtttt tactctaggc tcagcattac ctgatttctt 26940tacatctact gacttaataa ctttcttgta atacttagct acttccttat ctaagttact 27000agtgtttcta cctaatccac atgcttctaa taagttacct gggtcttgtt tgtcgttttg 27060gatgtcttgg tgacctggca tatttgtttt gtaatcaaca ccccagtatt cagctaaata 27120agctaagaca cgagctccat tgtctaatga ttttttagaa cgttctttat cactaaagta 27180acaaatttct acaccaatag caccatcatt agcgttaatt ccgtaccata ggtcatccat 27240aggagcgtta tacaacacat gccaagcttt ttctgtagta ggaacacata tgatagcttc 27300tttatcatct acaaagatat gtgcggatgc agtggaagcc caatcaatgt tatatgtatt 27360tttgtaataa tctacattat tttgagctgt agtattaata ttccctgtat catgagctac 27420aataaaaacg ggttttttaa ccgccatagc ttgacctgtg cgtcttgttc caataggcag 27480taaatcatat ctaacattta cacctttcca aatttctatc attactgttc acctacttct 27540tttgggttat cttctttatc taattcagac actaagtctt tttctacttt accatgttct 27600aatggttctg catgacttgt atctatgtct tcattattaa ctccttcagg agccatcggc 27660atctttgtag gaggtaactc tgaggtacta ttcattgctt cactcttgta tgttaaagct 27720ttatctgggt cattataatc tctaggtttg ttaaagtcct gtacaatagg gctatccgct 27780atacctttag tgtcatgact tacaagaaca cctaaaccag tcaagaaact aataactaca 27840cctgcaattg cagtgccttg gtttacaata tcttctgcac ctttgattcc tagtaaacta 27900catacactaa caataaacgt agctaaaaca ggtacaaaac ctgtccaaaa tgtagcactt 27960tttgcttttg cagtaatatt gttacctgct attaataatg gttttttatc tttttttgac 28020ataaaaaaat accatccttt ctgttattgt aaagctaata ataatataac aaaaagaatg 28080gttttagtta ttaaatttta agttattgtt cgttaatttg agaaagtgtt ttgattactt 28140ctgacatttg tttattatct aagtcttcta acttagtgtg tggaagtaaa tctaatttat 28200cccaaatatc ttttttagtt gtgaattttt cattaataat tgctctaccg attaaacttt 28260cggtataata aatttgtttt gcagatgcca tattagtatc taccgttgtc aaaaatttat 28320aaaactttat aaatcctatt cctttttcaa cgtatcccct tttgagtacc ctcatcatta 28380ctgattactc ttatatactc tactcggatt tgtatgatac tccaaaggct taaattccca 28440tacaacgaat ggtacacata tttagtatct tatttgtgat aacttaaata ttatagttag 28500ctaaattaat actagcatta aggtctctat caatactaaa accacattta catttaaata 28560ctctgtctga tagttttagg tttttatgga tactaccaca tgtagaacat gttttactag 28620aagggaaaaa tctatctaca ataacaagtt caattccttg tctttcacat ttgtattcta 28680attgccttct aaactcataa aatccttgtt tttgtattgc tttagctaaa tgtctattct 28740tcatcatccc ttttacattc aaatcttcaa taacaattct tctaggtttg gttttcacga 28800tagaagatgt tacttgatgt aaatagtttt tacgaatatt agacaatctt cgttgtagga 28860gtttaatttg tttttctagt tttatgatat tgcaagtttt gacaaacgta ctcccttctt 28920tatttttttg gtatttgaaa gataccttac gttgcaacct acgtaatcgt ttttctaatt 28980ttttaacctt tattgtttta ttaatattac cataaatagt accatctgaa catacagcta 29040actcttttat ccctaaatca atacctaagg actcgttggt caaatcttca tatttatttt 29100cttcttctat agagatactt atataccagt atttaccatc aaaagtaatt ctaggattgt 29160agtacttagt gtctataggt agttgttcag aagttctaac ccaacctacc ttttctatta 29220gtactttttt ctcttttact actagtgcat acgtgtcatt atagaaacta ggtcttgttt 29280tctttttaga tttgaactta gggaaaccag atttcttttt aaaaaatttt ttatatgcat 29340tgcatgcgtc tttaactgct tgtttaggaa cattgttact tacttcatgt aaccaactaa 29400actctttagt tttctttagt tgtgtaattt cttttcttaa tactgtgtct tgtataaatt 29460ttttaccttg ttcgtaattt tcttgctgtt ttgctatagt ccaattatat ataaatcgtg 29520ctataccagc tgatttacat aattttaatt tttgttgctt ggtaggttta agtctgactt 29580ttttcgttat cactattcaa ttcacctact atttttttag cgttgttctt gtgtcttatt 29640tgatttactt ctaagaactt atttggtttt atttctgttt tttacggagc atataggatt 29700tgaacctatg agtgaaataa atcacctatt gagttagcaa cccaacctct taagccactt 29760gagtaatact ccttagtata attaaacata catacataaa ccgtctcact ggtaagtaac 29820atattagacc tattgttaag ttaatcacta cgcttgactc tattaggtag ctaacctaag 29880tccatctcac gtaacctact aaagcagtac aaccataggg ttgagtccgt ttaatagtgt 29940aatgtgatac taacatatta attagtaact ttcacatggt atgaagaatt ttaacggcat 30000ctttatattt ttaccaatta ttattttgca ggtttatgct actcgtacta gtatcgtatg 30060ttatcaaaca tttttcaatg ctccaactgc

atgtacttgt taaggtgtat ttgtaaagga 30120taccaccaaa accccctaca aaaattaagc ccatcggata ctatacttta taaacctaat 30180acattactgc taagcattcc gattgtaata aacattacta ttgacgaatt accttaccga 30240cgtataccga taagttttaa ttcgttcgac aatcttacgc cttacaggta ccaccctgtt 30300taaatcagcc attatgtatg tatgtttaat tatactacat ttaaagtata acatattatc 30360attcatttgt caattaaaaa atgtgttacg ttttatagtt tttttatact agggtaaaaa 30420cgtaataaaa gacctagttt cgacaaataa aaataaggag aagaatgttt attatgcaaa 30480atgaaattat agctctttat gagcttatat ataatataac atactatttt gagtttgtca 30540agttattttt tactttttta tcttgataat tcttcttgta ctctatccca atatttttct 30600gattctgttc tattatcctc aatgtgagca gtagtacatt tacatttgat acagtataaa 30660tgctttatat gtccctcttc tcttttctga gctctttttc ttggtactgt aaaagtatta 30720ccacattttg aacaaactaa attactgtgg aacattttct gtcttttttt catgattatc 30780aatccttttc ttttaatttg ttttatattt agattatatc aggtgttgag tattaggtca 30840acacctttat ttaatgtttc tagttaattt ttaatactca agctttaaga aacaagatgg 30900gtattcttct gatactggag tagtatattt atcttctaag ttatctaggg ctttgaataa 30960tttatcaacg tactcaatat cagttcctat agtgtcaata atttttgtat tatctattgt 31020actttgagga acgttattac ttttcatttt ctttaatctt cgagtatgtt ttgatttaat 31080attgagattt tgagaatata gcatttcttt ataaacctca ttccatgttt taccaaagtt 31140ggggttgata atactactaa ttttaggtgt taattttcta acccttttat ttgcttcttg 31200tttccaatca ttattttcag gtcttttttg taaaaactct agtttatttt ctaattccat 31260aacttcgttc tctactgaag ataacctatc attttctttt tgtaaatcag tcaccaattt 31320atttaatctt tctgactcct caaagtactt aagcatttct tttttagctt cttgaggatt 31380atctataata gctttagcaa aatcatcatt catgtacatt ccatactttc taatatcagg 31440tagaacttct gaagttaccc aacgcttgaa tcgtttagct tattctagtt ttgatgaaaa 31500gattaaactg tataaacctg attcgttgat taatgtcaca ttccttaatt gacctgcgta 31560cctaatttgg gtacgtagct tatcttcatc ctctgcatgg ttatttatag cgtttcgata 31620atttgaatat cctaatatct tagctacttc gttacctaca aagtaagttt gattgtcttt 31680aactactgtt cttactgatt ctccttcaaa attaaacatt aattggtttt ccatgttaca 31740tcagtccttt tcttttaatt gatactctta ttctaacgta agacttaata aatgtcaatg 31800ctttttgtta aattttatgt aattattttg agaaatcctt ttatatcaag gtttttaaag 31860atttttttac ctatttggaa aataaggagg attccttata tatataataa ataattataa 31920atactaaaat aataatacta gttataataa ttaataatat atataggaaa gtcaacaaag 31980agtaataaaa aagtgactta cttaaaagtc actaattttc aaatactaat ttaaatgatt 32040ctatgaataa agggttaatg aatactgtat cagaattaat atcctcagag actctaactc 32100taactgatgc ttgtccatgt cctctaattg ttccatttat ctctctttgt gtatactcaa 32160tactatcgtc agagattaaa taatattttt ttccactaat cattgttacc tcagcatgtt 32220ttaccatatc aaaactccta actaaattta ttgaaaatga aagttataat agaacctaac 32280actagtaata gtactttctc ggtagtatcc ttctttcttg tgtccttaac aactgtattg 32340ttagtgagtt cttttatctt ttcgtctaat ctatctagct gtatgtagat agacgattgt 32400ttctcactat taacagctac ttctttgtct aaactaacta ccatttttct tagttcatca 32460acttcatttt ctaattcctt atacgtattt ttatcaatat agctaccatc ttgtatttta 32520tcttttatct tatctacttg tcctacaagg ttttttagtt cttcattcaa ctaaagtcac 32580ctcttaatgt ctaacttttc agattctgaa tggacgtcat agttttcgaa aaagttatta 32640ataatttgca tataatcctc agtaactatc tcaccgtatg acgttttagt atttatttca 32700aacctaagct taccaaactc atggaggtct atttctttaa taacggtatt aggattatca 32760gatggtatgt aataataatc aaaatatata atagagccgt tgataagcaa cctatcaatc 32820ctatagacgt ggaagaattt tctatctcgt ctaaagtgag ctaaggcatc tttaaactct 32880aattttaata tatctttata cttagtcaaa tcaacttacc cccttataat taattttgag 32940ctacactagt tttgtgttat aatagttatt gcagtagcag atataagtat tatgtttaat 33000aaaattagca accaccaacc acctgtactt attaaccata atgaaaaaca agatagtata 33060taaacaacca ccaagtagcc tatatatttc ataatgtttt tacactcttt taatactact 33120acgtatgcta gtgatttaga taagctaaac agaaaataaa aataaaaaat aaaaagaggt 33180atagctataa tgcctgctag tataaccact aattacacct aatttctttt agctagataa 33240taaaatctta tataatacaa ctttaatata acattgaaac ctgtttataa atcaacaatg 33300ttacattaat agtgtacggt atattttaaa ttaggaggac tgaactaata gggtgaataa 33360taacatagct gtatttatat ttaaaactct aataattatt atttttattt tgtttatttt 33420gtctattatt aactcactgt cattaatata ctctattcga cctagtacag ttatgactta 33480ctttatattc ggtgggatag tttctaatgt ggcattaaca ataactgata aattattatt 33540acacaaagaa gaccccttac ccgattatat tctaaaagaa gtagagctaa ataacaatga 33600attacaagta ctaaagaaaa ttgtggagtc acaaactaat gtttctgctg aggaagtaag 33660agtaagagca aaagcacaac gtcgaatact aaaagataaa aagagagatg ctgtcgatga 33720aaacgaagaa ggacattaag gaacaacgta aagagctaaa agataatgca accgctgttt 33780ccttaacaaa aaaaggagat aaacgtattg caagtcctag tagggtgtgt tgtttatgtg 33840gtcaatctct ttcagggatg aactatacta aaggtaaatc tatagctaaa gttaatcatt 33900ttcatttaca gtattctaag tacttatatt ttgacatatg cgcagatatt aataactgtt 33960acaagaattt aaagaaagta ggtgaattga tagagtgagc gctgaaagtt taagggatat 34020gttatctaag aagaaaattg aagacgaaga taaacgtaaa tatatagctg atggatttat 34080gtcaggtatt actaaactta tgtatgactt taataaaaag attgatagag gggaaataga 34140agtaagagac cctaatgatt tgtacaaagt atttgttatc ttccaacaaa tgcaaaactt 34200aattacagat ggttctgatg gtggtggtgc tataccgcaa ttatcaagac cacaacaaga 34260gctctttgat gaaataacaa atgagaatag taaaggtgag aaagaagtag atttagagaa 34320gttatctcaa ctatctgctg atgacattac tgctatgatt attgataaag aaaaggttat 34380gaacgaagag aactcaaata cattctaaag aaaggtgtat atgaatggac ggtaaagaat 34440tattaaaaat aacacaagaa acattcggta cacaaaatgt tacgcaagaa caagttgacc 34500atattatcaa catgttaaac cctagtactt atatgctaaa atatcatacg ttacgaggtc 34560acccgataac ttttagtatt ccaaacaggg acagaagtaa agcacaagct catagacctt 34620ggcaagtccg taaacatact gtgcggacta taaacctttt ctaaacttgg aaactctaag 34680tgcttaaaca agcatatgac aatcaagtgc taaatttagt agtgatacta ataaatgcct 34740aacgactaaa cttactggta aacttataaa tggataagtg tagaacagta taaaagggaa 34800accgtaacga aagagggcgt atacacctaa atgtatacgt atgatatagt ctaatcccct 34860aataaatatc gggaaaccga gggtaataaa tgatagtaaa tgacaaccat cctaataaag 34920ttgtgattaa atcacgacag cttggataaa gctttgttca agtaaaactt tcactaaaag 34980gaaaaactct aagggataat atcctatgac aattccttgc taaaaaaatg cctaacgact 35040aaatttctag gtagataaac gaataggttt attgagaact agataaaagg gttaatgacc 35100cgtaacgtga aagagttaat gtcttttcat tagctaagat atagtctaaa ccgattctta 35160aatgaatgtt aaagtattac gaaagtaacg gtagtaattg taagtgagat gggtgtaatg 35220gaaatggtac attttgctga tatgcatagt tatgcaagtg taaagtgtct atacacattc 35280cctagattat aagttgggga attaaaactc tgttaaacgg tcataggaaa ataaagaata 35340tcctggtaag agagactaag tcctaatgga tagagttaat accgtgctaa atcaacctaa 35400taagttgtaa atgccgaacg actaaatttc tagatagctt attaaaagga ataagtgaaa 35460actagataag aaagtcttga caaaaatacc aaagtaagtt aatatattaa ataggaggtg 35520gaaaaacaaa tgcctagaaa aaaacacatg aagaatttgt aaaacaagta gaagacatag 35580caggaaatga atacgctgta atagggcatt atgaatacgc aaatcaaaat ataaaaatgt 35640ttcataacga atgtaaggaa gaatttgaaa taagaccaaa taatttccta caaggtaaaa 35700gatgttctgc ttgtagaagt aaaagaataa gtaggataca agataaacca cttagtgaag 35760ttaaaagaca actaaaagag aaacataagg gtactataga gattataggt gagtatacaa 35820atactcacac taaaacagat tttaaatgtt taacatgcaa ccatactttc tcttcagaac 35880ctaattctgt tttaagactg agtggatgtc ctaaatgtaa agtttctaaa agggaaaaat 35940taatagctga attccttaaa gaaaataata tacgttttaa agaacagaaa agatttaaag 36000attgtgttca taaaagacct ctaatatttg atttctacct attagattta aatactttaa 36060tagaatatga tggattacag cacagtaagc caatagatta ttttggcggt gttaaagctt 36120ttgaagaatt gaagtataga gatagcttaa aagatgatta cgcaaaaaga aataatatta 36180ggatggtaag agtgtcctat aaacaaaaag agaaagagat aatagaagaa ttagaaagtg 36240ttttgggtgt ggtaacccgt caagaaagta aagcagagag ctcaacacca aaaagttgag 36300ttaagatata gtctagtccg tatgtaaata tcacgaaagt gacggtagta acgactaatg 36360aacagatgaa gaaattcgta caatcaagac ttaatccagt attagaaaaa ccttatttta 36420gagatattgt taattgggat aaggactcat taggttataa acaaataaga aattctagtt 36480tatttttcag aactagtagt aaagctagta ctgtcgaagg tgtggatagg taacaagtcc 36540acattaaact ctgttaaacg gggaaacccc taacgtaaag acgagggcaa tcccgtgcta 36600aatgttgact ttataaaaag aatatgatat aatgtattta taaggttagc taaatgccta 36660acgactaaat ttctaggtat ctatacaaaa gggtatagtg agaactagat aagaaaaccg 36720ccaagattat ttttaataag taaataattt tatgaaaaaa agcgtgtaaa gcatattact 36780aatgataaga ataaagtaca agccttaatt aaagattatc aatatatgga cttacatgga 36840tgagttattt gaaggggaat ataaattttt agaaccttat ataaatagtg acacagctat 36900caaaggaact aatattagaa cttcttggcg gaagtaaagc agagaacctt tcacctaata 36960gaaaggttat gatatagtct aaacccactc ttaagtaagt gttaaagtac taggaaacta 37020ggggtacaaa ttgattgact atctttcact tgacgagtac gaccgtgtaa ataatttagc 37080tgagagctca gctttagaat ctatgtcaag ttcacctttt aaaatagtaa gaaggtggtc 37140tacaccaact gtaagagatt atggtataga taaactgtat aaacaatcag accaatggtt 37200ttatggttat gattgtgaac actgtggtca ttttaatgaa atgaagtatg ctgattataa 37260acctgatgac ttagaaaata gtggtaatgt attactagta aatccagatg gaatagatga 37320gatagctaaa actgtccaag atggtactta ccaatatgtt tgtcaaaaat gtggaaagcc 37380tttagatagg tggtactctg gacgttgggc ttgtaaatat gccgagagaa cagaaaataa 37440taaaggtatt cgtggatact atataagtca attaaacgca acgtggataa gctgtgatga 37500gattaaagaa aaagaaatga atacagaatc taaacaaagc ttttataact acatcatcgg 37560agcccctttt gacgatgtaa aaatgaaagt aacagaagat gatgtattca ataataaatc 37620tgaaattgca aaaacacaat tatttaatag agataaatac aaatttattt cttgcagtgt 37680tgactggggt aattttcact ggtgtgctgt acacggtatg acagaagatg gtcatgtaga 37740tttaatacgt ttattttctg ttaagaagaa tagtagacct gatatggtag aagcagacct 37800agaaagaatt atattggagt tctctaagta cgaccctgat attattgttg ctgataatgg 37860tgattctggt aataatatcc ttaaattgat taattttttt ggtaaagata aagtatttgg 37920ttgcacttat aagtccagcc cacgttcatc aggtcaattg tacgcacagt ttaatgagaa 37980tagtaataca gtaactgtag ataaattaat gcataataaa cgttatatac aggatttaaa 38040agctaaacgt attagtgtat accaacaagt agatgaagag ttaaaaactt atcttaaaca 38100ttggcaaaac gttattataa tggatgaaga agatgataag acaggagaaa tgtaccaaat 38160tattaaacgc agaggagacg attttgtaat atggtcgtct ataaacagtg ttaaacgggc 38220atagtaaaat aatgtataga aaaacaatat actggtaaga aaccctaaat ctgactatac 38280acagacagtg ggaaccaacc gtgctaaatt cttaatttaa atattaacat tatatttttt 38340aatgttatta ttaaattaag ataaaagcct aacgactaaa ttcgttacta ttaacgtaag 38400agattaaaat aatttattga gtatactaaa aaggagggta gttaagtggt ttatgataac 38460gagtggttta ttaatagaat taaagatgtt agaccagagg actatgaaga atatgaattt 38520ttagatgact atgttaatca gtacacaaaa ctaagagcta ttcataaaaa atgtggtaac 38580aaaatactta taacaccatc aacatttatg agtaaacgta agacaggttg taatacatgt 38640tctcaaaaaa gagtccatag taagcaaaga aaaacacatg aagaatacca aaaggaatta 38700cctgaaggta taatggctat aacaaaatat gaaggtgcat ttaagaagat aactttacac 38760tgtttctttt gtgatagtac ttatactatt actgcaagag atattttaaa gtataaacaa 38820tgttcgagat gtaacaggag atttaatagg acattggaag atattaaatt tgaagtacgt 38880aaagaaacga aaggaaacta tgaagtagtt tcaaatcatt ataaaaatgc acacaccccc 38940atagaaataa agcataatga gtgcggaaaa acatatcggg gaactatggc aaattttaga 39000aaaggtagaa gatgctcaca ctgtagaaat tccataggtg agaaattagt agaaagttat 39060ctagagcaaa aaggtataac atatgaaaaa caaaaaactt ttgaaggctt aaagttaata 39120aataacttat catatgattt ttattttcct gaatataact tacttatcga atatcaaggt 39180gaacaacacg ttaaacctgt caagcatttt ggaggagaag aacaatttaa gctacaaaaa 39240aagatagata gtataaaaag ttcttatgca aaagataacg gttatgagct ttttgagata 39300ttctatacaa ctaaggatta caaaagtata gagaaattgt taaacaataa attattttat 39360tcgtaaagca ctgagttatc aatctagata actaagatat agtctaatcc cctaataaat 39420atcgggaaac cgagggtatg aaatgcatta cgcacagtct tcagtaattg gttacattgg 39480tcttactcgt ttaaaagaat tgtatgataa aggcaacggt acagcattca catccacttt 39540tataccaacg gattataata atacacaaaa caactcgtct aatgagttct attttgatga 39600ataagaaagg actgacgact tgacaaatat attaaattat gatacaatac aagaagatga 39660tataagcaag gagacattta atttattaat tgaagagcct ttaacattat catatgtttc 39720tatacatagt gattttttag ataataaata cgattacata tataaatcct taggctttga 39780taatttcatg gactgttatt tatacgtaac aagagaacca gaacgtatat ataaaggcgg 39840agctaaagat ataggctcat tgaataaagt aaaaagaact gtagtacgta atgggaaaga 39900aattgaaatg acaatctatg aagataataa aaacgatgat aaacctaaag agagtaatag 39960tgaagaacca aaagaaccta aaactgctaa aggttctagg gttattactc acggtgatga 40020tgagaaacct aatcctaaaa agattgccag ttctctatct accttaaaga ataaaggtgt 40080gaacactgac cacatagatg gcaacgcatc attatataaa gaatttgtag atgataataa 40140taatacaata ggactagctt cctttaaaga gacagattct gatattatat tacatggata 40200tgtatcagac tttgaaacta ctggcgtagg tgctaggtct ataatagagt taatttattt 40260agcaataaag aagaacaaga acgctgttgt ctatgctata gaattacctc aagctataga 40320gttcttaaaa ttgttagggt ttattaaaaa taaagattac tatgtattaa aaaaacaaga 40380tataaagtta tttttaggtg agtacagtga gcttatttag cactgtactc atttatacaa 40440ttatatatat aagtattatt atattagtag ttgtaaatgt aatagtaaaa gaaaaaagat 40500tgaataatgc taagcagtta cttatacaag taaaaaagga tattataaac aacttaaaaa 40560agggagatat gaatgattaa agataataat acaaaaacat tggaagagtt aattacacct 40620atttctacag aagaaaaaga aaataaagtt aaagaattta gtaaaacatt atgtgagatg 40680attaataagc tatatagttc ttacaatgta ttaaggcaag accctattga tgaaacacaa 40740agattagacg gttctctaat ggtgtttcaa agtagattag atgatacatt aacaggtgaa 40800gaacaccaaa aactttttaa attagctttt gattataata ttgatatttt tgaagctaac 40860aagcagttta aagaagatgt acaaaatgga gaagctatta agttaggtga tgttgttgta 40920accgacacag ctttaagtaa tgttttatct agtaatgagc ttaatgttag tattacattt 40980atgttaagca aagactatga agaaaagaaa cgtattgaag aagaagaaaa ggaaaaacta 41040gataagttat aatagatatt atgagacctt tatggatagg taggaataaa taatatgaaa 41100cgtaagttta gtagtaatga gattactata acacttataa ctattgtagt tgctctattt 41160atagtattaa ttacagtagc atttaacaag taccaaattg ctaaagaaga taaggacaga 41220tatcaaaagc tagtagaaat ttatcaaaaa gcagatgatg atgacggtaa aactaaaaaa 41280aggtatgttg agaagttaaa tagggctgag gaagaactta aaaaggttaa agaagaaact 41340aattataaag gttataatga taaaacagaa aaagaaagag ataaagagga taagagtgta 41400agagaacgta tttatggtaa tgataaggat aaagatttag tattagtaaa taataaggtt 41460gttgtaagta atgaagttac tagacctaag ataatagaag ataatggtgt cagtacagtt 41520gtagtacctc ctgttgtaag tcctgttgag ccaccaagtg aacctagttt atcttctcct 41580actataccta aacctattat tcctaatcct attaacccta aacctattat tcctaatcct 41640attaacccta atcctattct acctaaacct aacatcccta cccctaaccc actaccccct 41700atagaacctg aaaaacctat agaacctgaa aaacctatag aacctgaaaa acctatagaa 41760cctgaaaaac ctatagaacc tgaaaaacct agctcagata ctacaatacc tttagttcca 41820ttggaaccta gcacacctgc agatgaaagt aatgatacta atggagaggg ataacctctc 41880cttttttttg ctatattaaa agagtaataa aataaacatt atagttggtg attttttgat 41940aggattaaac gtacttacag ctatatccgt agtttttgct tgtgtaagtc tactagcact 42000aatggtattt gcgtatatta aaactgaaaa aagtagtaag ttggttctat atttgatata 42060tgctataatt gctataggtt cttatgtagt attaacaatg tttcaagcca cgtcaatcat 42120tataaaaaat gatgtcatag actctattga gaatacggag cagtatgtag ggtttaataa 42180ccctttaatt gtttttggta taagtttctt tggagctgta ataggcagtt tttggttttt 42240agttatgaag attgtaaata ctaggaattt aaaaaataaa aaattaaagg attgaagcat 42300ttgctatttt caaaagacga taaatgggat gaagcaaaag actttataaa aggtcaagga 42360ttagcagata attggataga agtagtggat tattatagac agataggtgg taaacatgta 42420gctatgttta ttgctattga taaagttaaa tatatggtac tagaagctac aaaggataat 42480aaagtaatat tggtagataa ggataataat attgtgttag aggattatga tattgttatg 42540gaaagtaaga aaatgtttta ctatatagaa gaaccattcg aagtaaagat aaatattcct 42600aaacatatcc aagacattac ctataataac actgttatac taactactat tcgaggaggt 42660aaataaaaag ttgcctgatt tatttaaaag tctaaggtta ggtagtatgt ataaagaaga 42720cactgaagac cttatggttc ctatagatga cggaatacaa gctaacatta gacaaataga 42780acaagataca aaagagatgc aagaaattac taaatctcta tatggtaaac agcaagctta 42840cgcagaacca tttttagaaa tgatggatac aaatcctgat tatagagata agaagagcta 42900catgaggaat gctcataact tacatgaagt gttaaagaaa tttggtaata actctatact 42960aaatgctata attattacaa gagctaacca agtatctaca tactgtaaac ctgccagata 43020ttcagaaaaa ggcgtaggtt ttgaagttaa attaaaagac ttagacgcta cacctggtat 43080taaagaaaaa gaacagatga aacgtattga agaatttatt cttaatacag gtacagataa 43140agatatagac agggattcat tccaagagtt ttgtaaaaaa atagtaagag atacttacac 43200gtacgaccaa gttaacttcg aaaaagtttt tagtcctaaa aacaaaacta agatggagaa 43260gtttattgca gtagacccta gcaccatttt ttatgctact gataaaaacg gtaagataat 43320taaaggtggc aatcgctttg tacaggtcat agataagcaa gtagtagcta gttttacaag 43380cagagaactt gtcatgggta ttaggaaccc taggtcagac ttaaattcta gtgggtatgg 43440attgtcagaa gtagagattg caatgaaaga atttatagct tacaataata ccgaaagttt 43500taacgatagg ttctttagcc atggcggtaa caataagtta caattaaatt aaaataaaaa 43560aatatttaat ataaactttg ccgtgcatgt ttagtaataa gcatgtatca agggttaaat 43620gctatgaaat cctaaagctc aattaactaa aacagaaaga gaaatcttag acggaaaagt 43680tacgaaagta gaaaaaataa ttgagatacg ttaaggttaa atcctaagac gaagaacaat 43740ggaagtatag cagggaaagt cctaagttca aatgaataag gaagaccctc aacgactatc 43800tcctgacggg agagtaaagc cacaagctat tggtggaaga aaaatcctta tcctacgaaa 43860agtaggaatg acaaatagtc tccactcgta tcgaaagata gagctataga ttaactatag 43920gagttataag tagcgttata actcaaagaa agttaaaatt tatagataat tacaatttta 43980ttccaaataa ctgttgacat tatttccttt atgtagtata ttatatacta taaggaggtg 44040aatataatgt cggaagagaa atataaacgt attaatatta gattactacc aacaaaagaa 44100caagaagaat taatgtggaa gtccgtaaat aatgttagat ttattaagaa ttattttatt 44160gctcgatgtt acgaggaaaa agataaaggt acttttataa atttgtcttt ggaaaaagac 44220tttaaaaaag aattaacata tattactaaa ctaaacgaat ataaatggtt aaccgaatcc 44280gatagacatt ctaaagtagt agcaataaaa gatgttttga atggttttgt tagatactat 44340aagggcatag caggaaaacc taaatttaga aagagagggc taacacctaa taccttttct 44400gttagaaatg atgtaatgcc tagtggatta tgtaggttta gaagagatgg taatacattt 44460aaagtatctg taataggata tattaagtat tctaaaagaa gctttaataa tttcaaacat 44520atatttgata ttatagagga taaagataaa ttttattctc ctgtaataag acatgatggt 44580aagtactggt atatttcatt gttatataaa gataacttag ttacaaatca aaaaccaaga 44640gagttaactg atgaaattat aggtatagat ttaggattaa gaacattaat gacttgttca 44700aatggtatta aagtcagaaa tattaattta gatagaaaag ttttaatact agaaaaaaga 44760gaacgacgat tacaaaaaca ggtttttaga aaatatgaca tgaataaaca aggtaataaa 44820tatgttaaaa ctaaaaatat tattaagtta gaacgtaaaa taagacacat aagaagaaaa 44880cttaaaagta taagaaataa tcatatacac acagaaacta aaaaaatagt tgaaatgtta 44940ccgaaagaaa tagttataga agatttacat gttaaagaaa tgttaaaaga taaatggaga 45000agacatgaaa tacaatatgc taagttcttt gctataagac aaatactttc atataagtgt 45060aaagatagag gtattctact aactgttgct aatagatggt acccttctag tcagttatgt 45120agtaattgtg aaactagagt aactggtaaa

caaaaaacaa ctattaagtc gggttatcat 45180acttttaaat gtaaaaactg taatcataat ctagatagag atttaaacgc tagtattaac 45240ttaaagaact atagatactc caattggtat cgaaataata ttattgagaa acaacaatag 45300taatattata tgtaccgttc catgaacggg agtttaagcc tttggagtat ctagttagta 45360gaatattaaa agtaactaac ttagttagtg aatgaatgaa tggattattc aaaaacagtt 45420acagaataag gaataaaata tataattatt tataaatttt aactcatggt actactcggg 45480gcatattaca gattagagct gaccaacagc aatctcaaca tgcgttagaa aattttaaaa 45540gagaatggaa atctagtttt tcaggtataa atggtagctg gcaggtgcct gttatgatgg 45600ctgatgatgt taagtttgtt aatatgacac caacagcaaa tgatatgcaa tttgagaaat 45660ggttaaactt tttaatcaat attatttctg ctttgtatgg tatagaccct tctgaaatag 45720gattccctaa tagaggagga ggagccacag ggtcaaaagg cggttctaca ttgaatgagt 45780cagaccctgc taagaaacaa caacagtcta tgaataaagg tttacagcct ctattaagat 45840ttatagaaga attaattaat agacacatta tatctgaatt tggtgataag tatactttcc 45900aatttgttgg aggagatact aagtctgaat tagataagct tagtatctta caaaaagaag 45960tacaagtata taaaactgta aatgaagcaa gggaagaaca aggattgaaa ccaatagatg 46020gtggagatgt aattcttgat tcagcatttt tacaaagtac agcacaagaa atacaaaaag 46080accaatattt agatactaaa caaaaagaaa gacttcaatt acttatgagc tatacacaac 46140cacaaactga tgagcctact gatgatagta aacaagaaac aactaatcaa gaggtaggaa 46200cagataatca gttaaaaggt gatgataacg tatatagaac acaaacatca aataaaggac 46260aaggaagaaa aggtgagaaa tcttccgact ttatgtaaat aatactaaca acctaattaa 46320tacttaggtt gttatttttt aatttggagc tataaatatt ttatgctata ctatgtgtgt 46380agtaatgaat aatgttgatg atatactttt tgttatatta tgtatgtaca tataaaataa 46440caattaagtg aggtgtataa tcactttgga agaaatgaaa tttaatgctt ttgttcctat 46500ggacttaaag aaatccatag atacggaaga tgatacaaat aaatattcta tcgtatctgg 46560ttgggcttcc acaccagctg ttgatttgca gaatgacatt ataaatccaa aaggtattga 46620tatagaatac tttaaaaaaa atggatatat taactacgaa catcaacaag ataatgtagt 46680aggtatacct acagataact gttatgttga tttagaaaaa ggtttattta tagaagctaa 46740gctatggaaa gatgatgaaa atgttataaa aatgttagac ctagctgaga aactagaaaa 46800gtcaggtagt ggtagacgtt tagggttttc tatagaaggc gctgttaaga aacgtaacat 46860aaatgacaat agaattgttg atgaacttat gattacaggg gtagcactag taaaaaaccc 46920agctaatcct gaagctacat gggagagttt tgttaaatca ttccttactg gaacggaaac 46980aacaccagac acacaagtag atgcaggagc cttacgtaaa gagtcattag caagctctat 47040tactaattta acctatgtaa caaaaattaa agatgttaaa gagtataatg atatttggaa 47100taatgtagta gaggacttaa ctaaatctaa taatatgggt tatgaagaat cagttattac 47160attacaatta gccaaaggac tatcaagaaa agatgctgag atagcagtta tgagtattaa 47220taaaaaaaat ttagaatagg ggattatatt atatgcctac ggaattacaa aatattctac 47280aagaatatga taacttagac aaagaagaag tatcaaaatc tgtagaagag tctaaagaag 47340aagtaaaaga agataaaaca gaagacacta aaacagaaga cactaaaaca gaagaaaaag 47400aagaaattaa aaatgaagta gaagctacag aagagcaagt agcagaagct aaagaagaac 47460cacaagaacc tgcaaaggtt actgaagaag atgctaaaga agcacatgaa caagaagaaa 47520atctagaaga agaagtatct aagtcagcta aggagtcgaa agaccctgta gataaaaaag 47580atactaaaac agaagacaaa gacaacgaga aacgaaaaaa taaaaaagac aaaaaagaag 47640aaaaagatga agaagaggaa gaaaaaacat ctaaatctat ttctgataaa gatattgtag 47700atggtttccg tactatcttg aaatcattcc aagacattaa aaaagaaaat gaacaatatg 47760tgactaaatc agatttagaa gaagtaacta aatctattca agctttaact gataaaatta 47820attctaatga agaagtttct aaatcagttg agagcaacca agaagataaa gaagaagcag 47880tagaaaaatc cgtaacgact aataacactt cgaatgaaca agatgtagtt ggttatgtag 47940ctaaatcagt acaaacagaa gaacaagcag aaactacaga agataaagaa gaacaagaag 48000tagaagttaa agaagaaagt agagacttat ctgtagaaga ccgtgaaaaa ttcatgagta 48060cctataaaga aaaatctcaa aacccacata cgaatcgttc agaagtattg aatgcttatc 48120aagcttactt aaatatccgc aacaatccag agcaagcaag tgaaaaagac tttaatattg 48180taaaagaatt tgctaatctt taattaagaa acaaagttgt gttatattat agtgtgtaaa 48240ataaaacaat aaaaaaaaag agcatatatg aaaggtgata tatataaatg aaccaaaatg 48300aactttcaaa aaagcaacat gcagttgctg atgaattaca agaaaaatta tcgaaatcct 48360tccaaactgg atatggtatc actcctgaaa cacaagtgga tgcaggtgct ttacgtcgtg 48420aaattttaga cgaccaaatc actatgctta catggggaaa taatgattta gtattttacc 48480gtgatgttgc acgtagacca gctgaatcaa cagtaattaa atatgatgtt ttcttacgtc 48540acggtaaagt aggtcattct cgttttgtac gtgaaatcgg agtagcgtca gtttcagacc 48600ctaatatccg tcaaaagacc gttacaatga aatacatttc tgatactaaa aatatgtcat 48660tggcatctag tttagtaaat aacattgctg accctggtca aatcttgact gaagatgcta 48720tctcagttgt tgctaaaaca attgaatggg cttcattcta tggtgatgct tcattaactt 48780ctgaagttgg tggagaagga ctagaatttg atggactagc taaattaatt gatgctgata 48840acgttatcga cgctaaaggc gctcacttag atgagaaatt attaaaccta gcttcagtta 48900aaatcggtaa aggttttggt acagctacag atgcttacat gcctatcggt gtacattctg 48960actttgttac taatatttta ggtcgacaaa tgcaattaat gcaagacaat agtggtaatg 49020taaatactgg tttcagtgtt aacggattct attcatctcg tggattcatt agattacatg 49080gttctactgt aatggaaaat gaattaatcc tagatgaaac tttaatccca caaccaaatg 49140caccacaacc agctacagta aaagctgaag taaaaacaaa ccaaaaaggt aaatttacta 49200aagaagaaga ccgtgcaggt ttatcttata aagtagttgt tcactctgat gaagctgaat 49260cagcaccatc agaagcacaa gttgctacag taacaaatgc tacagatgga gtagaattaa 49320agattactgt taactctatg taccaacaaa gcccacaatt cgtatctatt taccgtcaag 49380gtaaagaaac aggtatgtac tacttaatta aacgtgtagc acttaaagat gcacaagaag 49440atggttcttt agtattcgtt gataaaaacg aaacattacc tgaaacagca gacgtattcg 49500ttggtgaaat gtcaccacaa gtattacact tgttcgagtt attaccaatg atgaaattac 49560cattagctca aattaatgct agtattacat ttgcagtatt atggtatggt gctttagcgt 49620tacgtgctcc taaaaaatgg gctcgtatta aaaacgtaag ttaccttgca ttaaaatagt 49680aaatacaatt aaaaattgaa tacaatagaa taaggagtat acctaagggt tgctcctttt 49740ttattactac ttatagtata caagaaagga atttaaaaat caatgttaac ttataaatta 49800aaaaatatta aaatggctac tgtacatggt caagtagaag tagacgataa aggcgtagtt 49860aaaggactaa ctgctaaaca agaaaaagat tttgctaatt taccaggttt tacacatatg 49920gaagacaaga aaacaacaaa gaaagaagta aagcctaagg aagaaaaaga agagaagaaa 49980ccaactaaaa aaacaactaa aaaagaagat aagtaggttg ataaaatggt aaacagtatg 50040tttggtggta gtttagaccc ttacgaaagc tctttatcat atgagtatcc ttatcaccca 50100tctggaaacc caaaacatat agataaaaga gaattagata gtattactct agctgattat 50160ggttggtcag cagatgctgt gaaagcctat atgtttggta taacagtaca aaaccccgat 50220acaggacaac ctatgggtga tgatttttat aatcatatat tagaaagagc tataggtaaa 50280gcggaaagag ctttagatat atctatttta cctgacttac aacatgaaat gagagattac 50340tacgaaacag aatttaatag ttatatgttt gtacacgcat ataaaaaacc tatattacag 50400gtagaaaatt tacaactaca atttaatggt agacctatgt atgattatcc agctaactgg 50460tggaaagtgg agcatttagc aggtcacgta cagttattcc ctacagcttt aatgcagacg 50520ggtcaatcta tgtcttacga tgctgtattc agtggatacc ctcaattagc aggaatgtac 50580ccaccaagtg gagcaacttt tgcacctcaa atgattacat tagattatat tagtggtatg 50640ttacctagac aaagagcagg tagaactaaa ccatgggaag taccaccaga attagagcaa 50700ttagttatta aatatgcact aaaagaaatt taccaaatat ggggttacga tgatattacc 50760ctgtgtgtag cgtaagttgc acattttcaa aggttaactg ctaagaaatc ctaaagctaa 50820ctaaactaca aagtaagtcg aaagactaag cttgaatgtt gagaaatcag aaaaaattag 50880ttagatactc taaggttaaa tcctaaagag aagagcaatg gaagtttagc atcgaaagtc 50940ctaagtcaat agataaggaa tacgttcaac gactattctg tatagacgac agaagtaaag 51000ctccaagtga ttgggagaag aaaaatcttt accctagtct tagggataac aaatagtctg 51060cacacgtctt gaaaaggagt gctaggaatt gacctagact tatttagtag cgtaagtaag 51120gaaacaatgt taattaaatg aaaacttcct aggaagttaa tttaattaac atatggtaat 51180ctcattatcg gtgcaggaat agcaaacaaa actctagatg tagatggtat tacagaaaca 51240ataggtacta cacaatctgc tatgtatggt ggagcaagtg ctcaaatact acaaatcaat 51300gaagatataa aagagctatt agctgggtta aaatcttact ttggctccaa tatgataggc 51360atatagtagg aaggagatat taaatgcaaa aaccttttat gataggtact aataataata 51420cttctaatat aattaataag tctactatgt atacatctac aacacaagca gatgaacaag 51480aacaaaagtt atctacagct agactagagt ttgacactaa ggatatgaga agatttgtca 51540atgatagagg tataaaggta ctgtgggaaa gagcttactt ttgtccttgc cttaaccctg 51600acacaggaca tcctagagta gattgtccta ggtgtcacgg taaaggtatt gcctatttac 51660ctcctaaaga gacaataatg gctattcaat ctcaagaaaa aggaactaac aatttagata 51720taggaatttt agatactggt acagctatag gaactacaca actagaaaaa cgagtatctt 51780atagagacag gtttactgtt cctgaagtat tgatgccaca acaacttata taccatgtta 51840ctaaagagcg tatacaaaaa ggtattcctt tgtattatga tgtcaaagaa gtaactttta 51900ttacatctaa cgatggtaat gtttatgaag atgactataa tatagagaat aatagattat 51960tcatggacgc taagtttgaa aacaaaacta tatccttaaa tattttaatg gtacttagat 52020atgtagtatc agatatatta aaagaaagtc gataccaata tactaaattt aatcaaccta 52080atacaaagtt tgaaaattta cctcagaagc tattattaaa aagggaagac gttattgtac 52140tacctgagcc atttaaagtt aatgatggta tagaagagga cttagagata caggtagaag 52200accctaaaaa agaatctaaa gataatcatt caggtggttt ctttggagga atgctataat 52260gcctataaaa gcaactagac ctaagttatt tagagacaag aactataaaa atataggtaa 52320gagaacagta gatgctatgc gttctgatat tttagataga ttacaagcta cagcattaca 52380agtagataat gtaagtgtca aacgcatgcc tacttatcta caaataactg agaaaaagct 52440agagaagcaa ggtgtaatag accttaagaa agcttttgct cattcatcta aaaagaaaag 52500gactaaagat ggtggttggt atctaacggt gcctataaga ataaaaacaa gtaagatgaa 52560taataaaaca taccaagact taaggtcttt aaaaatagac agttcaagta attcagtatc 52620tactcttact gattatctag aaggtagacg aagtaatatt agtcacccat cactaaagcc 52680tgctagtaaa tcaagtagaa ttactaaagt aagaaatggt aaaaaatcta gttactttat 52740gtttagaaca gtatctagta aatcccctgc aagttcatgg atattaaata gagataaggt 52800taatgaaaac aacttctcta aaacaacatt aaagtatgtt agaaatctga tgaactggaa 52860gattaagaat ttaatgtaga aaggttatgg aagtaggatg gcaataacat cagtagactc 52920atatttatta gagcaaataa agcccagatt acatacagta ctaagtaatt gttatattat 52980agatgaagtt ttaaaagact ttgattatca aactagggaa atgttcaaag aggctttttg 53040tggtaagaac gcaaagcacg aagtaacagt agggttcaat ttccctagct ttaaaaacaa 53100ctacgaagct cattacctaa tacaactagg gcaaggtcaa gaggttaaaa actctttagg 53160tagtatacaa gggtcttatc tagaagcttc gggtaacaca tatagtgaac aatcagtagc 53220taaaagagaa ggtaatcgtt tagtatttca tgtatctaaa cctatttcta atgtaataag 53280agtagaagac atagcgtttg attcttacga tgatgttaaa gtatcagata acactgtatc 53340ttttaattat actaacaatg agacttatga aggctacaac gcaaatattg tatatgtaga 53400aaaaacaaat gatagtaaag ggttagtaaa aggtattacc atagaagaac aagtaacaat 53460tgtgggtatg tcgtataatg tagatgttgc tagatgttta gatgccgtat taaaaatgat 53520attgatatct atgagagaca gtatagaaga acaacaaaca ttccagctac aaaatcttgc 53580atttggagat atcgcaccta tattccaaga cggtgagtca tctatctttg gtagacctac 53640tataattaaa tacacaagtt cattagattt agattataca ataacacaag atattaataa 53700gattactttc aagaataaag gagcaaaaag ataatggtta agaaaacacc taaaggtaaa 53760acctttacag gttatgtaca tatagataca tttttaaaaa cagcacagac cttgtttaat 53820atgaaagagt cacaggtagc aggttttaaa gcctacatgg aaggtaaaca ctacctgttc 53880aatgaaaaag actttattcc atttttagaa aagtatttag gtagagaatt agaaatttaa 53940tatatagata ggagaattat acatggcagt tgaaccgttt ccacgaagac ctgtcactcg 54000tccacatgca gtcattaatg tagacagtac aggtatcggt aaatcagcta gctccagtga 54060aaagatttta tgtttaattg gacaagctga aggtggtaaa cctgataccg tatatgaatt 54120aagaaactac gcacaagcta aaagactatt ccgctcaggt gaattacttg atgcaattga 54180attagcttgg ggttctaatc cacaatacac agcaggtaag atttttgcta tgcgtgtaga 54240ggatgctaaa ccagctacag ctgaagtagg cggattgaaa gttacttcac agatttatgg 54300taacgtagct aacaacattc aagtaggatt agaaaaaaat acaatcagta attcattacg 54360tttacattta atcttccaag atgatagatt 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gcatctcaaa agattggttc agactcagat 59460ataacaaaca gaataaaaga aatgaaaaca ctgaaccaag ttacagaaga gtataataaa 59520ttagtaaaag atgccagttc agctaaggag tacacaaagc aactaagagc taatcgtaat 59580atggttagag gtcatatatc taggtctgaa ggctctaata gaatgtccta tgaccaaggt 59640gctagagtac gttctgaatt aggtaaagta gacacttttg aaaagcaacg agaagctaac 59700aatagaagaa taaaagaaaa ccaagataga tatagaggtt atagacaaca acaacaagat 59760ttagtaggca aaagagctcg tggtgaaata agttctgagg attataaaaa acaatcagct 59820tctattaaaa tgatgattga tgaaagtgaa aagctttctg aagtttatag aaaaacaggt 59880gctgaattag acaagtcaat caactactat aaaaatagtg ctaaaaaaca gtttgctcag 59940cgtgagatag aacagcaacg aggaacaatg ggtaaattgt tccaagatag attaccatct 60000attggtgcac atgctactat ggcagtaact gctcttgcag gtggtatgta tatgaaaggt 60060gcctccttat ccgaggcaaa tagacctatg gtaacatcat taggacaaaa ttcagataat 60120atggatatag acgcagtaag aaatacatat ggagatttgt caatagataa taagcttggt 60180tataattcaa ctgacatgct aaaaatggct

acgtcatatg aaagttctat aggacataaa 60240agcgatgcag atacgtataa aggagctaaa cagttagctg taggtggtcg ttcattaggt 60300atacaagacc aagaagctta tcagcaatcc atgtcacaac ttatgcatac aggtggcgta 60360aactcagata atatgaaagc tatgcaagat gctttcttag gtggtatacg tgaatctgat 60420atggttggta gacaagacga gcaattaaga gctttaagta ctattgccga gcagtcagga 60480caaggtagaa cattatctaa aggggaaatg tctaatctta cttctttaca agctcaagta 60540gcgggtacag gtagtaaagg tctacaaggt gcacaaggag ctcaagcctt aagtagtatt 60600gaccaaggta ttaaaaatgg tatgggtaat tcttatacta gattagcaat gggatggggt 60660actaagtacc aaggattaga aggtatgcat gacttacaag cacaaatgga taaaggtata 60720tcagacccta ataacttagt taatatattt gaccaagcta ataatatagg aagtacaaca 60780aaagaaaaac aagccatagc taaaaaaggc tttgaaagca tgggagctaa cttaacacaa 60840gagcaaacag atgagttgta caatctttat gcctcaggta aactatctaa agaagagtta 60900gctagtaaag ctaagagcat ggaacaagaa ggctctaaag caggagataa aaataaggat 60960aagtattccg agtctaaagc aggtagaaat gaccagaaca aagctaagac agatgataaa 61020gctgaggata tttatgactt agctcaacct 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gttctttatt attacatcct gaatatggtt 72000ctaacattca taatttattt ggtttaaata tacctgaaca agctacgtta attgaagtag 72060atgtattaaa aaccctaaca tcagatagta gagttaaatc agctaactta aaaggttggg 72120agataaaagg taatgaatac tatgggtcat ttaatgtaga aatcaagtcc gtagaagaat 72180ctatagactt tgtattaggt caagatgatt caggtgtctt tgctttattt gactaagaaa 72240ggaaatttat atgagaacaa gaaagttaac acagatatta tctaggttaa tggataagac 72300gatacaaggt acaagcaaaa taacagactt tacacccggt tcagctgtac gctctctttt 72360agaagcagta gctttagaaa tagaacagta ttatatatta acaagagaaa acattaattg 72420gggcattcaa gaagggatta ttgaagcttt tgattttcaa aaaagaaaag ctaagcgttc 72480ttatggtaat gtagatattc aattttacca acctttagac atgagaatgt atatacctgc 72540aggtactaca ttctcatcta ctaggcaaga ataccctcaa caatttgaaa cattagttga 72600ttactatgct gaagaaggaa ccactgaaat tacagtagaa gtttactgta aagaagttgg 72660tattgtaggt aatatacctg aagatatcat taatacaata gcctcaggct ctagtttaat 72720tcgtacaatt acaaacccga cttcctttaa tacaggaaca aaagaagaat ctcaagagga 72780ttttaaacgt aggttccata tgtttgtaga 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gtatatgaac cttttaaaaa tatattctat 73680accaataaat caaaattaaa tggtgaagat tatttaatgg gttattatta tagatttgct 73740gtgataaatg tttctgttga tggttacttt cctttagaga ttatagatgt aataaatgaa 73800tttaaacccg cgggtgttaa gttatattta acttatgatg gtgctactac cataaagggt 73860gatggtgttg ttaaatggct taaaaatcta cctaaaattg aaacatatac ggatttagat 73920agattattag gttatgatga aactttctat gggcatttaa acatgagtga agcaacagct 73980gaacaatctg ataaaacaag gttcagaaca aataagagta cattaaatag tgaagatatt 74040ctatcaggct cttctaatat tggacgtaga tttataaatt atgcttatgt tacgacatat 74100gcatatgaac ctactagtac atcagccgtc acacatatag cttctttaaa tgataaagga 74160aaagaagcac ctttagatta ttacttatat acatccttaa agaatactaa tgatataaat 74220atatcaatgg aaactgctta tggtgtgtct tatttataca ataactttaa tgtaggtgag 74280tttatcagta gatacaaacc taatatagat ataactagag ataatgctaa aaaacaaata 74340tccgattttg taggggaact aacaattgat ttctttgcaa aagctttagt ttcacctgat 74400gaatcattac ctattaagtt acaaatattt gattttcgta ctaatgaatg gttaactgta 74460tcagaaacag aactatcttt ttacgagaaa aacataggtg taaacatagg ttatataaga 74520gattacttaa atgatgacct taatttattt acaagattag aggttaatat aggtaaagat 74580gagcaaaaag atataagtat taactacatg gatttacatt tttataatta taaaaaagat 74640gtgtatacta tcaaaccttt taaggcacta gttgaaaact acatagattt gactaaagat 74700acttatattg aaggctttaa agtagcctca ttattaaatg gagacataat taataaaaat 74760ggatatcaac ccataaaata tttaaggtta catgctactt atgattcaac taaacctatt 74820gtaagtatta caggtaaaaa cagcaataat gaggtacaaa ataatacacc tatagattta 74880tataaaaata caactaatag aaacttattg caatcatata aaggtgatag tagtatattc 74940aagggtgttg taagcacaaa agagttttat atctcatcat ggtctgacac cttatataac 75000tcaacgtatt tatctaaagt actagaaccg caaaaagtat atactttgtc attcgagatg 75060gaaatcacag atgctaatat ggacttaaaa acatattctg acaatcatgg tatatattta 75120tatagtagta ctaaaggtat tgttgctaat ggtgttaaaa gcatgcaaag aaagataggt 75180aataagattg atgtatctac cacatttaca gcacctacaa ttacagacca tagacttgtt 75240gtttacacag gtagatatac agcagatggt

actgcctcta aaacacctat tgcttctaat 75300acggtaaaag taacaaacct tcaactaaaa gaaggagcta ctaagaagga ctacacggta 75360gcacctgaag atgtaactaa tgttatagac aaagctattg tgtttgataa catattaaca 75420gatatacaaa caataggaat aaatacaaca acacctctta aaaatattga gctaagttat 75480tcttattatg gggataattg gacaaaccta aaaacaataa gtaatttaag tcaaggtgaa 75540acaataacac ctaataacct agtagattta tatggcttag aaacaataga ttactcaagt 75600attacacctt tctctagggt tatacttaaa actatatgga atgctaacct gaataattta 75660acaaataaaa aaggtagtat ttctaacatg agtaataact atttcaatgc tgtatggcaa 75720gaggtagata tgatatataa cactacatta agtagcatga gcatacttac tgatagtgaa 75780ggtaatgtat ttgatagttc aacaggacag gtaataaaat tagcacctaa gatataccaa 75840ggatatactg atgtagatag attgctaacg tctacgactc tatataacga gaatattaca 75900ttaggttcaa atagatttat ttatgactta cgggatatgt tactatcaag tgatacattc 75960acagtagata ataaaattaa agtaatagat acatacacag aagtacagta aagatattga 76020caataaagta ttaatatgat atagtaaggt atgcgtatta tagtatacct tgttatatta 76080atacagaata ctagacatga aaggaataaa aaatatggct atagcaacaa atgcttcaca 76140tgtagaatta gctaaataca ttgtaagtaa ggctgattct atttatttaa caattggtaa 76200aagtacagcg tggtctaatg aaacaagtcc acctcaacct gaagaaacag caacatcatt 76260acaagaagtt atcggatata aaaaagcaac taaggtagca ttagttagac ctgcaaaaac 76320aacgggtgat gaaagtaaaa aagaaattac atatggtaat aaacgatggg tagaaattga 76380ctcagctaat gcagttgctg aaggtgctaa gtgggtgtac ttagaaagta gtattgttgg 76440agatgagtta cccttaggta cgtatagaca agtaggattt gttatggatt tgttagctaa 76500agatagtatt tctaaattta acttattacc tagtgaagtg caatctacag gaactttatt 76560attttatgat aataaacaat tccaaaatag aagtgaacaa acaactgtaa aagagcgctt 76620tatcattgaa gtttaaaaag gagaattgaa tatatatggc aattaatttt aaaagttctc 76680catacttaga tagatttgac cctacaaaag atagaacaag agtactattt aatccagata 76740gaccactaca acaatcagaa ctaaatgaaa tgcagtctat tgaacaatat tacttaaaaa 76800atttagggga ttctattttt aaagatgggg ataaacaatc aggattaggt tttacattaa 76860ctaaagataa tgtactacaa gttaacccag gttatgtgta tataaatggt aagatacgtt 76920actatagtag tgaagacact gttaaaatta 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ctattaattt cacacctgtt aatggtacta 77820agcctattga ccaaagtgtt gtacttgtag actatactta ctacttagct cgtaaagatg 77880ctgtttttat taataagttt ggtgatattg ctattcttaa aggtgaacct aatattatga 77940gattagtaac accaccttta aatacagacc ctgagaacct acaattaggt actgtaacag 78000tattaccaga ctctaatgaa gcagtatgta tttcatatgc tattactaga ttatctatgg 78060aagacttaca aaaagtaaaa actagagtag ataatttaga gtataatcaa gctgttaatg 78120ctttggatga tggtgcaatg gaaaaacaaa acccattaac attacgttct gtatttagtg 78180aaggttttat atctttagat aaagccgaca ttacacatcc tgactttggt attgtattta 78240gttttgatga tgcagaggct actctagcgt ataaagaagc tgtgaaccaa cctaagatta 78300ttcaaggaga cactacagct catatatggg gtcgactaat ttccgcacca tttacagaag 78360agcgtacaat ttatcaagga caagcatccg aaactttaaa tgtaaaccct tataatatac 78420caaataaaca aggtgtgtta aaattaactc ctagtgaaga taactggata gacactcaga 78480atgtaacaat cacagaacag aaaactaaaa aagtaacaat gaaaagattc tggagacata 78540atgaaagtta ttatggagaa acagaacatt acttatattc taacttacag ttagataaag 78600gacaagagtg gaaaggtaag tcatacgcat atgatagaga acatggtaga acaggtactc 78660tattagaggc tggaggacag cgtacacttg aagaaatgat tgaatttatt cgtgttcgtg 78720acgtatcttt cgaagttaat ggtttaaatc ctaatgataa taatttgtat attttatttg 78780atggtgttcg ttgtgctatt acaccagcaa caggttatag aaaaggttct gaagatggta 78840caattatgtc tgatgctaaa ggcacagcta aaggtacatt tacaattcca gcaggtattc 78900gttgcggtaa tagagaagta acattgaaaa atgctaactc tacaagtgct acaacatata 78960cagctcaagg acgtaagaag actgtacaag atgttattat caaaacacgt gttacagtaa 79020acttagtaga cccattagca caatcattcc aatatgatga aagtagaact attagttctt 79080taggtttata ctttgctagt aaaggagata agtctagtaa tgtaactgta caaattcgtg 79140gtatgggaga tacaggttac cctaacaaga cggtatatgc tgaaacagta atcaactcag 79200atgatattaa agtatctaat aatgctagtg ctgaaactag agtatacttt gatgacccta 79260tgatggctga agcaggtaaa gagtatgcta ttgtcattat tacagaaaat agtgattata 79320ctatgtgggt cggaacaaga acaaaaccta agattgataa acctaatgaa gttattagcg 79380gtaatccata tgtacaaggc gttctattta gttcatctaa cgctagtact tggactccac 79440accaaaattc agatttaaaa tttggtgtat atacctctaa gtttaatgaa acagctacaa 79500ttgaatttga acctattaag aatgtatcag cagatagatt agttttaatg tctacgtact 79560taactcctga aagaacaggt tgtacttggg aaattaaaat gattttagat gacatggcta 79620catctactac atttgaccaa ttaaaatggg aacctattgg taactaccaa gatttagagg 79680tattaggttt agctaaacaa gttaaattaa aagctacatt tgagtctaat aagtatattt 79740cacctttatt aagttctaat gacttaacgt ttactacatt cttaactgag ttaaaaggtt 79800catatatcgg tagagctatt gatatgacag aagctccata caacacaata agatttagtt 79860atgaagcatt cttacctaag ggcactaatg ttattcctaa gtattcagac gatgatggta 79920aaacttggaa aacatttact aagtctgctc aggtagttaa ggctaataga gactttaata 79980gatatgttat tgatgagaaa gtaaatcaat ctactaagaa taacaaatta caagtaagat 80040tagacttatc aactgaaaat agtttcttaa gacctcgtgt acgtagactt atggttacaa 80100caagagatga gtaagtttaa agagggtttc ataccctctt tttatttaac taaggaagtg 80160atattatgcc tacagaatat agagaccctt actcacaagc taaactcttt attcctactg 80220tagaagaaaa agctataaaa gaaatggaac aaacatataa agataaacta caagaagtta 80280atgagcttat tgatgagctt aaaaaattga aaggtgatta cacacatgac gtttaactac 80340acacctctaa cagaatcaca aagattaaag gatatgtacc ctaaagtaaa tgaaatgggt 80400aaatacttaa aagaagaagt taacttatct gatttaaaaa cgattagtta tcctgattta 80460aataatgttt taaatttcat acaagactca ggtgactact ttgtaacaca agcaagaaac 80520accccgcaag gtgtaagtaa tatagggttt ttacacttag ataaaaaggg tagtacttat 80580tataagttat attatgcccc gtctaacaca aataaattgt ttgtgaaaac ttattataat 80640ggtactgtct atgattgggt tagttttaaa ctagatgaag gtacattata cgattcagga 80700aatacaatta atgtaaaaaa tttaacagag tccacaactc aatttgcaac actcataaat 80760ccccctaaaa gtaatttaaa cacaggatgg ataaattata aggaaagtaa aaatggtacc 80820tcagctttag ctgaatttaa tcctattaat tctacttcaa catttaaaat gattagaaag 80880ttaccacgcc aagaccaaca acctaactta ttaagagata gtttattcac attaccaatg 80940acggatgtag ctaatataag aacggattat atagataata catctttttg gggttttact 81000aataatgcat ctacctcaac agttagatat atgggtgaaa atactattca attagatgat 81060ggaggggaat catatcctac agttatgtca aaacgattta gaataggaga cgaactatat 81120gtaggggata ctgttacaat gtctgtttat attaaagtaa atgaccctaa tttgttaaat 81180ggtaatttcc cctactttga gattgctggg tataattatg tttatcaaga caataaccca 81240tacacaggag gtaggagaga ggttaactat tatgacttat ctacggagtg gaaaaagttc 81300tcctttactt ttactttaca atcatataac caagagtcta gtaatgatag ggttaattat 81360atatcagccc tactaagatt taactgctct aattctacta ataatggagc tattgtgtat 81420tatgcactac caaaattaga aaaatcatac tcggtaactc cttttattac tcatacttat 81480gataaaagaa aatatgatga aatatggagt aattggactg agacaacaag taaagatgag 81540cttcaatcac acagtagcgt agatacatat agtaatgact actataaata cgtatgggat 81600taccaaagct cgaatggtag aagtctgcaa caattagcaa tgtctgtacc tcaaggtttt 81660tataccttct actgtgatgg ttctataagt ggaactccta gtaataaaac aatacaaggc 81720acaatacaag tagcgtataa aaataataat ataaacacta caaataaagt aatacaaatg 81780gattttagtg atactaaagg caagaaatat tctttaacat ataataaaga taataatggt 81840tggcaagcca tgaaagttca aatggctagt aatagccttt gggaaggaac gcttgacctt 81900gcttcaggaa acacagtaaa tctatcagat tcgttatata actatgattt tattgacgta 81960gtatattgga ctagaagttc tggacataat gcaactagaa gattccctgc tactacatct 82020agtattgtaa ttagagactt taacttagta aatgatggct ctaattctag cgtagatttc 82080tttgaaggat attgtgacat tactgataag ataaacgtca ctgctaaaat gtcaaaaaca 82140attaacctag atggaaatag aaataccaca acagtcgcac aattcaatca aacaggtcac 82200attgaagtac taagagtaat agggttaaca tatatttaag agaagaggtt ttatagatga 82260taaagtatga cattggtaaa gacgaaattg tgttacactt aaaagataat aaatatatta 82320tgggatatac tattgtaggt ggatatgaag agaacaatgg tgatgtaaaa gtatcaaggt 82380ctattctacc tgatggattc tttgttgatt ttgttagtaa taagtatgcg tattataaga 82440acactaacga agtaatatat aataaaagct ttgaagataa ctcgaagagt gtagaggata 82500tagaatacca accaccagaa gagtttgtac ctaaagaaga ctacaaaaaa ttagagagtg 82560aagtagagga actaaaaaga atgttacaag aattgttatc taagaaagga taaatagtat 82620ggcactaaat tttacaccta ttacggaaaa cagtacaata gcagacctaa caaaacaagt 82680taataacata ggtagtgtat taactgagga tagaaatatc tttgaagtaa ctacagactt 82740acaattagac gtaagtaaag cacagaaagt taagttaaca acggatagag gattagctaa 82800agatatagat tataccaatt acttaagaga cattaaaaaa gtaggtttat attacatagg 82860agcacgtaca ttggctacta tgtatgataa accagatatg gaaaatatag atgtattact 82920gcaagtatta acattagata ctgaggatag agtaatacaa atattgtata cattgtcaac 82980ggaggacagt aaatcaaaag tgatgcaccg attcgttact aactaccaaa catcacaatg 83040gcaagtagta caaagtttac ctaataataa atatacatca catataggtg gaagtccttt 83100tgatattaat acacaaggta catattacgt gtctaatatg tcggatatgc ctagtggtgt 83160ttatgaagga ttcttacaag tttccataga cagtaatgat aatagaatgt taagattaac 83220ggatagtaac acgggaaaag aatatcttaa tgttaagaaa tcgtatgaca attggggtga 83280ttggagaact gatttagacg tacaaaagat aagcaagtat cttgtatcta atgtaaatgg 83340agatgcggaa aacaataatt actcattatc cgtatataca tcagacaata taacattcca 83400acaagctata gctaaacata ttgaagaaac aagtaaaact gtttttactt tctatataca 83460aggtggtgtt tcaggctctc cgtctacggt tagttgcaga ggtatattta tatcagactc 83520aaacaactat actaatttat atggtgtata taccgcaata ggtactgacg gtagaactat 83580taatggttcc gtaaatggta atacatggaa cacaacaaaa acattacctg gttttaaaga 83640actatggaat ggagcacata actttaaaga tacaaataaa aaagaaacta tgtctgattc 83700tatatctaac taccaatacg tagagatata cacaagatac agagccttac aaaacacaaa 83760aggtacggat aaaacaggta ctttatgtca taagttttat atagatggag atggtattta 83820cacatgttca ggagcttatg tatcaggaga ctctaatatt ggagtagagt actatcgagt 83880aactttatct attactggtg atacatggac aattaaagat agtgcagtaa ataataataa 83940agaccaatat gttacacgtg ttgtaggtat ctctttacca tagactagga taattcctag 84000tctttttttt ttcttgacta actttaataa atatggtaag ataataaagg actaaaaaga 84060aaggagaata tatgcagtta agacaacaga atatatatac atatgtagat tttgatgaaa 84120gtgacgggta tattaaagat atcatactta agcgtgttca taaaacgtta ggagctaaga 84180aagagggcta tcaacatagc ttagctttta aacgaggtgt gtgggatggt tatgtggatt 84240tctacgatta tgctgagaac aaattcccta gcgggttgtt acctaagatg ataacattac 84300taggtgagtt acaatcaaga cataactttc aatacgaaat tattgatgaa aaatctgaaa 84360gctttttagc tgaagaagat attgatgatg aaatacaact actagataat aacgtaggta 84420agattacatt acgtgactat cagtatgaag ctgtgtttaa tagtcttgtc aattataatg 84480gtatatgcaa gcaagctacc aatgcaggta aattttgccc cttatagtag aaatattata 84540agtgtaactc ctttaattca tgggaactct ctcatttgag acaatcatga gccaagctta 84600ataaattact aggaaggtgc aacgactatt atgtacaatc aagtgattgg aaacagggag 84660aacctaagtc tcattagata tggttaagat atagtctgaa ctttgtagga gactacaaga 84720aggttaggag taacgaacct aatcgtaaca taattgaaaa cagaggttgc tagcggtatc 84780atagaccaac tattaccaca actagaaaaa ggagagcgtg tagctttttt tacaagttct 84840actgagattt ttaatcaatc tgctgaccgt ttaagtgaac gattgaatat accagtaggt 84900aaagtaggtt ctggtaagtt tgatgttaaa caagtaactg tagttatgat tcctactgtt 84960aactctaact taaaagaccc tacagaagga gtaaaagtat ctgctaaagt aaacttaagt 85020aaaaagatag ctaaagagat acttcctaaa tttgaaggtg gtaaaaatca aaaaaggtta 85080cttaagttat tattagaaag tacaacacct aaaactaaag tagagcagaa tgtgcttgat 85140atacttcaag atatttatca taattcaaag acggatgctg aagtattaat ggcattaaac 85200aatcataatg ttattttcca aaaagaagta agaaagaaaa atcaaaagag ctatgataaa 85260tatcataaaa tgcgtgagtt cctagactct atagctgtaa tgatagttga tgaagcacat 85320cacagtaaat cagattcatg gtatacaagt ttaatgtcct gtgagaatgc actatacagg 85380atagcactaa caggctccat agacatgaaa gatgagctac tatggatgcg tatgcaagca 85440ttattcggag atattattgt aagaacatct aatgagtttt taatcgagaa tggctattca 85500gctagaccta caataaatat tatccctatt gctaaccctg atgatataga taatattaag 85560gattacaggg atgcatataa taaaggtatt gtacataacg agtttagaaa taaacttatt 85620gcaaaactaa cagctaagtg gtataatcaa gataaagcta cgcttattat tattaatttt 85680gttgagcatg gtgaaatact atccactatg ttgaatgaaa tgggtgtaga gaatttcttt 85740ttacatggtg aaatagagtc ggatatgcgt aaacaaaagt tagatgaaat gcgtaatggt 85800aaacttaaag ttatgattgc tacaagcctt attgatgagg gtgttgatat cagtggtatt 85860cgttcattaa tcctaggtgc aggtggtaaa tctttacgac aaacactaca acgtgtaggt 85920cgtgcgttac gtaaaaagaa agaagataat acaacacaga tatttgattt taatgacatg 85980acacataagt ttttatataa acattctaat gaacgtagaa aaatatatga agaagaaaaa 86040tttgaaatta aagaattagg aaagtaggta tgagtagtga ctaagacaga aagaagatta 86100tatgattaca ttgaaaaaaa atcaaaaaat aatacttatc aaatagctac taaaaaagag 86160ttagcagaag aactagatgt ctcagtctct actttatcta aaaaccttaa aagattagag 86220caggataaca aaattaatgt tgtctctaaa agaggaaata aaggtggtat tgttatatca 86280ctagtaagag attatgatac agatagtctc ttacatttta atgacacaaa tgataatgtt 86340attacttcta atctagaata cgctactgaa ttacgaaata gattttttcc tagctacgta 86400tatgaaagaa aagaaaataa acgtagaaca aaattagaaa tggttcaata taatgctagt 86460aaagataaaa acaggaaaat aatatcagat atgaattttt ataatagtag cttaccttac 86520cctactaaag atatttttaa tatgtcttat gaccctgagg gtttttataa agcttatatc 86580ttatgtaagt tatatgacca atatgctata gcacacatga atgctaaata tatacaacat 86640ttaacattat caaatggtaa tgaagacgta gatagacata agcatttatc tgagtactac 86700agaaagaaaa tgttacagaa tttatcacga gatagtattt gtaaagactt ctttggtagt 86760aagacattta atacattcta caacttttac ttaaagataa aagataagaa cattaatgtt 86820tttaaataca tgcaaaatgt ttttaagaat accacatttg ggtttgagaa taaaacacaa 86880ccttacccta tacctgcacc aaattttttt agttccgata aatacttaac taattatgaa 86940aattatgtaa aaggtattaa acgaggtgta aataaaacaa atagacaaat tggggaagta 87000gagtctttaa ttaagtcatc tgattactta ttaaatcctg ctgtagcaca attacatcaa 87060ctatatacaa cacctttaaa tgaagagata catgatattg atacaatgtt taaaacagct 87120ttagatatag aagatactat ttatggtata tttaatggca tgaaacatat tatactttta 87180tcatataata aatatataga acatctaata gaaaaattac ctagtaaaca taaaaactta 87240ttaaataaat ttattaaaca atgtattgta aatgagtatt cacctactac aatacctaac 87300aatgctagac tatctatgtt tttaatgcaa aaagagtata aagcaaatat cgcagaatta 87360aatggtggta tagatagaag agacttaata gatataagtt tagtaaacac tacagactta 87420agtaaacaag atattgtaaa tatagaacaa acaacaatga attatctaca tatgagaaga 87480tttacttcaa catcatatat tctacaaatg tatagtaatt atttaggata tgaggttaat 87540ttaacagaag ttaagactat tattgaaaag tataatttat ttaatgaaat accattgaca 87600aaagaaggta tgatagaata caataaggtt attgatatag taaaggatga cacatatgag 87660taaacgaatt aaggagatta tcctacataa gtctatgaag gatatacatt ttgcaagaga 87720agtactagat aagttaccta aaagtctatt tgctacagaa tcagaagaca tgggttactt 87780attcacagct ataaaaagaa cagcacacat tgctgataaa atgtcaaacg aatctttagc 87840tattaaagta gagcaattaa tgggtagtga taaacaagat gatgaaaaag taacacaaac 87900attaaaatat ttagatagtt tatatacagt agacatgaat aataaagacg attctgtaaa 87960ctatgaagta gaaaaatata ttaaaacaga aatgtctaaa gaagtattag ttaagttcat 88020agctgagaat aagcaagagg actcagataa cttacctgaa ctagtagaga aactaaaaca 88080aatagaagtt agtgacatta atggtactga tggtgaattt attgatttct ttgaagatat 88140agacaagaag agagaactat taagtaactt aagtattaat aaatattcta caggtttcca 88200ttctatagac caacaaattg aaggtggtat tggtagaggg gaagtaggac tagttattgc 88260acctacaggt agaggtaagt ctcttatggc aagtaattta ggtaagaact atgttaaaca 88320aggtttaaat gttttatata ttgccctaga ggaaaagatg gatagaatgg tattaagagc 88380ggaacaacaa atggtaggtg tacaaaagaa tcaattactt aatggtgact tatctttaaa 88440cacagatgct tataataaga tacaagaaca ctataaaaag aatagacaac tgctaggtaa 88500cttttatatc gttaaacata tgcctggtga ggtaacacca aaccaattag aacaaattat 88560aattaataca acaattaaga aagataagca tatagatgtt gttattattg attatcctaa 88620acttatgcgt aacccttacc ttaagtatca aagtgaatca gatgctggtg gtcgtatctt 88680tgaagatatt cgaaaattat cacaagaata caattttgtt tgttggacat tagcacaaac 88740aaacagaaca gcttatggtt cagaaattat tacaagtgaa catgttgagg gaagtagaaa 88800gattgtcaat gctgtagagg ttgcttttgc cgttaaccaa aaagatgaag aatttaaaaa 88860tggtttttta agattgtact tagacaaagt aagaaacagt tcaaacacag gtgagagatt 88920tgttaatctt aaagtagagc ctactaaaat ggttgttaga gatgaaacac cagaagaggc 88980agaagaacat aagcaaatac tagcggaact taatggtgaa gataaaagta gatttaaaga 89040aaaacctaat aaagctgaag ctattaataa ttcttttgga gggctgagtt tttaatggat 89100gactttacta agctttataa aaaagtacgt agaacattta cacgtaataa agcagaatgg 89160gattatacaa atacaggatt aagaaccttc caattaaaag gaactaatgt atgtgttaca 89220ttactagact ctatagcaag gaataataca acaggatata agtacaacgt tatgtctaat 89280aaagtacctg ctataccttg caatacacat caagaagtaa ttaaagcaat tgaatataag 89340ttaaaaaatt gagaaaaagc cttgacaatg tatttgttaa ggattatact tttattataa 89400acaataaaga ggtggtaaga tttgaactta aatgaagcaa aagtaaaatt aaaaaacttt 89460aaagtcattg tagtgaggga gatatagtat ttgatggttt catgggtagt ggtaccactg 89520ctattgcctg tatgaatact aatagaaatt atataggttt tgaattagat gaagaatact 89580ataatttagc cagtgaaaga atagaaaaac ataaggagat actaaacaat gaaaatgaca 89640atacaggaac tacaagataa cactgaattt ttaagacatg taaaggtaga tacggaagaa 89700gcaatggata tccttgaaga tatattaaga ggagagcctt acacagatga ggtatgtgaa 89760ttgatacatt tttattcaag taagctacta aatgagatta atgacaatca tatgtttaaa 89820ttacaggagt ttgctaatca tgatgttata ggaattagtg aagagggagt aaaataatga 89880taaaattatt acagggggat tgcctagagt cactagatac agttgaagat aatagtatcg 89940atgctattgt aacagaccct ccatataaca ttgcaaaaga gaacaggttc acaactatgg 90000gtagagctgg tattgatttt ggggaatggg ataaaaattt tgaagctact ttatggatta 90060ataaagatat accaaaagtt aaaaaaggtg gtaatatcgt tgtgttttgt gacatgagac 90120aatttacacc tattattgat actatggaag cattaggctg tgaatttaaa gatgttatac 90180gtatggaaaa atctaatcct atgcctcgta atagagatag acgatttatt tttgatactg 90240aatttgctct ttattttgtt aaaaaaggag ctaaatggac ttttaaccgt ttagatgaaa 90300aatatgaaag accttgtatt aaaacaagtg

taacacctag aagtgaaaaa ttaggtaaag 90360gacacccaac acagaaacct ttatatgcta tggaatggtt gttagagcgc ttaactaatg 90420aaggagacat tgttctagac tgcttcatgg gaagcggaac aacaggtgtc gcatgtaaaa 90480agttaaatag gaattttatt ggttgtgaat tatcagaaga atacttcagt atggcacaag 90540atagattact aaataataca aattaaaaca aaacccttga caacatgttt gttaagggtt 90600atacttttat cataacgtac taaaggagga cactaatgaa atttatattt tttacagata 90660gccattttca tatgtttacg aattatagta aacctgatga agaatatggt aatgatagat 90720ttaaagaaca aattgagaca ttacaaaaag tatttgattt agctagagaa aataaagcta 90780aagttatatt tgggggtgat ttgtaccaca aacgtaatgc agttgatact agggtatata 90840acaaagtgtt tgaaacattt gctaataatc aagatattca agtttacatg gtacgtggaa 90900atcatgatgc tatttcaaat agtttgtata ctcaatctag tattgacatt tttgaaacgt 90960tacctaatgt tgaagttact aagtctttgc gtagtgaatc attaagttca aaagtacagt 91020taactatgtg tgcatatggt gatgaggtac aggaaattaa agactttatt agtaagtcat 91080atgttaaaga taaggtaaat attttagtag cacacttagg cgtagagaat agtttaacag 91140gtaaaggctc ccatagatta gaaggtgcat ttggttacca agacttatta ccagaacaat 91200atgattttat tcttcttgga cattatcata gacgccaata tctaaacaat aatcctaacc 91260atatgtatgg tggttcttta atgcaacaat ccttttcaga tgaacaagaa gctaacggcg 91320tacacttaat agacacagac aagctaacat caacgttcat ttcattagat actagaaagt 91380ttattacagt acaaggtgac aatgtaccag ataacatgaa tgatttagta aaccaaggtc 91440actttattag gtttattggt actccagaac aagctaaagt aattgaatta gataaaacag 91500aagatgaatc taatgtacaa gtacaaatga agaaagaata cacagtagaa aagagagtcg 91560acgctgacgt gtctgacagc cctataacga ttacttctag ttatgcagac aaatactatc 91620cagaagcaaa agatgagctt ctagagtgtt taaaggcggt gttgtagtat gatagatatt 91680attataaaga atattaaacc aagtatagat aaatctaaac ctattttaca gttcttacat 91740aataaaagaa catatgatgt atgtaatgtt aaaaatattg atgatgcgat gtaccttatt 91800aacaaagtat tagaggaagc taactacgct cattattata cgagggttat tgaacaagaa 91860gattgttata ttctagatta tggttcacat caatgtttct ttaaattgtt aaaagaaggt 91920ggtacaaatg gttaagttta attatgtaga gatgaataac tttttagcta ttgagcatat 91980caagctaaat ctggataagc aaggtcttgt 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ctaaacttta tggagagcct tctattttaa aaggttatgg 101280tagaagaaat tcatgtttga tggcggtagc accttaattt atagggcgta tatggattaa 101340catatatgat aacactcttg aatttctgaa aagcctaagt gtgtaaacat aaggtaatca 101400gaagctaaga tttatttata gctaacttga caaaaacaaa tatatacatt atactagtta 101460ctaagaggtg ataataaatg tggaaaaata gtattagttt tcctaggctc gaagtaacta 101520aggatggaag agtaagaatg tggaataaat catggaaaag atatgtagaa aaaagacata 101580ggtatgataa agatggttac tcaataattt ctacaagaaa agaagatggt acatccacat 101640cagcaagagt tcatagatta gtagcagaag cgtatatacc aaacccatac aataaacctg 101700ttgtaaatca taagaatggg attaaagatg ataatagggt tgaaaattta gaatgggcta 101760ctatatcaga aaatactaaa catggttatg atgttttagg tgttaaacac gctaacgctc 101820aactaatttt agtctactta gatggcaaac ctttttctag ttatgactcc ttaactttaa 101880tgggtaaaac attaggtata aatagaaatc ttatacgtag agtagaaaaa gaaactgatg 101940ggtacatctc atttaaatgg atagaaaaac catataaagt acacaataaa gatttttgga 102000aaacatcaag aaaattaaat acgagaggct cttgttatgt tgtaaataat gtatactata 102060atagtgcaaa 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102900atgatatttt ctcacaagta agtaatgtac aagaccctat taagatgttt aatagggaag 102960atgatactaa agcagatagt aaatcaagta aatttcagct agagtttatt tataatacat 103020atgtgtacat tcttatatat gaaggtacat taaagctatt taaagctgat ggtacggagc 103080agttaacaca tgtagctgat attgaaacat ttaaagatat tattgacaca ctagaaaagg 103140atgatacaga aaatggaaaa agtgaatagt ttactagaat taaatacaac aattagacaa 103200aagaaagatg ttattgtcat ggttacacaa gatgagtgtg ctaaatgtga aattttaaaa 103260agtgtgattc ctcttttcga agcagaagga gatattacta aacctgttta tgttattaac 103320ttagatgata aagatgtaga tagagaaaaa gcggtcaagt tatttgacat tatgagtaca 103380cctgtactta ttggttataa agatggggaa cttgctaaga agttcgaaga ccaagtaaca 103440cctaaaaact taatggaatt agatttactt taatttgtaa ttacctacta cttatgctat 103500acttatatta gtaaaaggta gtaggttttt tcatgaaagg atgaatagtt atcgcaaaaa 103560ataagacatt aactatatat aatagtgata gatattttaa tatacatgta aaaaacaaag 103620atgaattatc taaagctatt aaagttacaa ctttaaatga agatgatata gaaaaagata 103680tggatatctt agctaataaa tcaactaggt atatactaag agacaataaa cattacatgc 103740tatttaatga gaagtataac aatgataagt tgattgaaaa aatatgtaag catggtggac 103800aagtaacata ctataccgat tcagtagttc cttactatgt gcttaaagac ttatcagccc 103860accctaaatc ctcagttgta tacagaatgc gtagtaaatt caatagcaaa gagatggata 103920atatagcctt gagtttcatg ggaacaaaag tcattattga tatttcagtt gtatttcctt 103980acgtcaatcc ttacgatatt attagaagtt tatatgatgt taaaacaaat gtagacgagg 104040ttcatctatc attccctcgt attagttcta tagacgctaa acaaggtaag tactatacgt 104100atgataaaga agcttataaa ctaaatcctg agtatacact tgattttgca gataaattaa 104160gagtttcttt gtccgtgtgg aaaatgtata tctatattct tgctagtaaa gaaaataaag 104220attatgaaat aatagaagac ctacttactg aattaaaaag acaaagaaag attaagattt 104280aggtgatttt gtgagtacag caaatagaag agatatagca agaaagatat ctgagagtac 104340agggtactat atccaagacg tagaagagat actagaagca gaaacaaaag ctatttctga 104400attgttactt gaagattatg ataaggtaaa gaatcataag tactttcaaa tagaagtagt 104460agagcgtaaa ggtaaaaaag catgggatgg actaaataaa acatacttca ctttacctaa 104520tagaaaggca ctaaagttta aacctttgtc tgaattagat aaagttatag atgtattaaa 104580caaagaggat taagttcctc ttttttttat tgactactat gattagatat gctatactgt 104640atttaagtta aagaagggat tggtaataac atgaaagttt taattttata cgactatatc 104700agagaggaac acttttcagt tagtaatgat ggtagtgtta agaatgtact actaaataca 104760cctaatggta gagtattaaa acaactatta tctaatattt ctggtattaa tcgagataga 104820agtacaaaag attatgatat tgagttttta tatcctatgg tgcctacacc tattaagaat 104880aattatggta aaacaattaa gtaccaagac gttaagttat ctgaagttaa accttactat 104940gaaagaatga atcaaataat cataaacaat aagtacgata ttattattcc tttaggtaag 105000ctaggggtta aatatttatt aaatgtatca gctattggta aagttagagg tgtacctaat 105060aaagtaacta ttactagtga agataaaaaa catgatgttt gggtattacc tacttatagc 105120atagagtaca caaacgttaa taagaatagt gagcgtcatg tagtagcaga ccttaagtta 105180ttaggtaagt ttgtagaaca aggtgaagac gtatttaaac ctaaagaagt taagtatgaa 105240cttgttacaa gtattgagcg tgtaagagaa atatttaata aagaagtaaa gaatgataat 105300catgacggtg tagacattac cgcatgggat ttagaaacta actcacttag tcctgataga 105360gaaggaagta aacccttagt attatcaatg

agttgggaaa atggtcaagg tgttacaata 105420cctttatata aatcagactt tacttgggag aatggacaac aagatattga tgaaattctt 105480tccttactaa aagaatgggt agctagcaaa gaagacatta aggtactaca taatgctact 105540tatgatataa attttctaat gacaacacaa ggtttcacag actttgaaaa taatcaagac 105600actaaggtag gttggtattt agctgtaaca caagaacaag cagagtctct aagattatca 105660gaccttgctt acgaagtaac agatgtagga ggatatgaca aaccccttga agattttaaa 105720gagtggtatg tattgaagct actaagattc ttatcagata aactaaaaga gattaaaaaa 105780gaaaataaaa aagttgttaa gaaagaatat aacataaaag caaatgagta tgatacttgg 105840ttgaaaaata aactcgataa cattgatata gaactaacag atgaagataa gtattatggt 105900atcacagaag agcaaaaaag atatttagag ttaaaactaa cacctgaggt tattacaaag 105960aatatgctta tggattctga atttaaagaa gtagccgaat catcacctga gtatatgagt 106020ttatctaaca aagctaaaga ttatgtatta ggtacatcta ttaatttaat taacacgtat 106080aaagacaata ctaaagttat taatgaggta gatggaggtg actttaatta tgattggatt 106140ccattagagc ttatgcatcc ttatgccagt ggtgacaccg atgtctgtag aagaatatac 106200tgtgatgtta ttgaaaagtt aaaagaacaa aatagaccta aagcattgga cttaatgtca 106260ataagttacc ctagattaat tagaacatta gctagaatac aatcaaatgg tttacattgt 106320gacctagaat acatgcataa aaatgatgaa ttttatatta atgagatgga aaaaacccac 106380caagaaatta gagaacattg ggctatccaa gaatttgagg agactaggta taatttatac 106440caattagcct tagcagaaca tgagaagaaa ccatctgata gaaataaaga aatacatgag 106500tatagagcta aatttaaaga tgaaggttgg aagtttaaac caagctcagg tgaccataaa 106560ggtgaagtat tgtatagcat tttaggtata cagttacctt atagtaaaga gacagttaag 106620gataaacctt tcagtaatgg tactaaagaa gatgagttat catggaaaga ttacaaaaca 106680gatactaagt ctataaagat ggcattatct ttggttgaga atgaagataa taaaaagcta 106740ctagacttac ttatttatta tgcctctttg caaactaaaa gaaattcttt tactaagaaa 106800ttacctaaaa gagtaaataa gaatacacat aatttacatg gtaactataa tagtacagga 106860actgcatgta ttacaggtga ttctttagtt attactgata aaggtataaa aaaaataaaa 106920gacttatcaa ataatagaaa agaaaaagta tttagtagta ttgatgtagg tattgttaat 106980agacagggaa atttagaaaa agcttcacac ttttattata gtggtgtaag aaatggatta 107040aagattactt tagaagatgg tactacatta actactactt taaaccaccc cttattacga 107100aataattatt atagtaatac tggtagggtt ctaaataaaa caaaacaaac aactaagcat 107160ttactagata atgattgggt tgtagctgaa gatttaaaaa taggtgatta tataaaaatg 107220tcttataatt ctaatcttta taataatagt tatattgatt tagatactaa agattttata 107280tatagtaaag aaaaaagtat tacaaacaca aaaagctata cactacctaa ttatgtatct 107340gaagattttg ctgaatggta cggtatgtat acagctgatg ggtctttttc tacaaataac 107400ggttcattca gtataagatt aactaatagt aatcttgaag ttaggaatag attctttaac 107460ctaactaaag atttatttga tattacacca tactacatta gtaataaaga tagaagtgat 107520tctattgaat tttcttcaat tggtttaggt agatggttag aacatatttt taatatgcaa 107580agtaaagcat taaataaaga aatcccacaa caaatattag atagccctaa aagtgtacaa 107640caagcatttc ttaagggttt aagtttagat actgcaacag aaaagaaaaa gtatcctagt 107700ttgtactata atactgtatc taataaaatg gctttacaaa taagaacaat gctaatgaat 107760atgggtatct attgtaggta ttctataggt aaagtttata aaaatattaa tagaaaagta 107820caaaatgaat gctattctat acaaataact tatgatgcat tagataaatt ttacgatgaa 107880atagggttta ttgagagtat taagcgtgat agagtaaagt ataaatcaga aaatctaaag 107940gcattaggca gaagaaacgg tattctttta tatgataatg ttttattagg taaaataaag 108000aaaattgaaa aaataaaaga tatggaattt tttgatttac atgttcctag tagccattca 108060tttgtagcta ataatattgt aaatcataat actagcaggc tttctagtaa caaccctaac 108120cttcagaatc ttcctgctca tacatctgat gtaaataagt ttgattatca ccaccctatt 108180aaacgttctt ttatctctag atttaaagat ggtgtaattt tacaagccga ttacagtgcc 108240ttagagatgc gtattacggc actatataca gatgataaag aaatgttaga gatgttttta 108300acaggacaag atattcataa aaatacggca agtattatgt atggtaaaag tatgaaggac 108360gtaacagcag aagaaagaca agccagtaaa gctgtagcct ttggtttaat ttacggttaa 108420caaaatatag ccgtagtaaa actaggtaaa cctattgagt atagggtgta tagttcacgt 108480taggagctac aggaaatggt agttaagaac tatgctaaca gggaaggctt taaaatgcta 108540atcctgtgta gaataattta agtgtaattt aataagtaag gatgatttaa atagaattta 108600aaataggaga aagatataat cacaataagc tatattctaa attagctcat gtatggtctc 108660atatgataga tagatgttat aatcctaaat gtaaggaata taaatattat ggattactag 108720gaataacagt agacgataga tggcataatt ttaataactt tcttaaggat gtagagttaa 108780ttgatggttg gagtttagag aagtataaaa atggtgagtt agtgttagat aaggatatta 108840aagaactagg taataaagta tatagcttag ataaatgtaa atgggctact agagaagaga 108900acttaggatt tgtaccttca agaagtaaaa agatattagg tatagaccct acaggtaaag 108960aatatacatt cttcaatcag tctaaatttg ctaaggaaca taacttaatt caaagccata 109020tttctgcagt tcttagaggg gaaagaaaac atcataagaa ctgggttttt aaaacactac 109080aagaatataa ttatcaacct gtagaaaacc cttctaaact ttatgcacct cactatgttg 109140cttataagaa tcatgtggaa attgattatg atagagtaaa aactaagcta ctaaagagac 109200taaatatacc tacgtcaggc actaacttta gaaaaatgga aaccggtgaa gattgttatg 109260ggattacatt caaaatagag aaaagagaac gatttgatta cacttaaaca cttaaattat 109320tttatcgaac gactatcaaa aggtgagctt tacgccgaga gggcttattg caatataacc 109380gagtagagta catgtagctc atacctacat ggaatagcct agaagtagat agtaacgtat 109440ttacttaaga tatagtctag tcccctaata aatatcggga aaccgagggt ataaacggag 109500tcagagtttt cgtttgcagg taaaaataat atgacagttg atgaagctac tgaaatattt 109560aataagtttt attctaataa acctgctatt aagaagtcta tagatgaaac tcatgagttt 109620gttcaaaaac atggatatgt agaaacaatg aatggacaca gaagatatat acactcagca 109680caatctagag ataaaaagat taaaaatgag ggtcttagac agtcctttaa cacgattatt 109740caaggtacag gtggttacct tactaacatg gctattactt atattgacga ctttattcaa 109800aataagaata tgaaatcgaa gttagtagct actgttcatg atagtattgt agtagactca 109860cctcctgaag aagttaatat tatggctaaa gttattgtcc atgtaatgga gaaccttcct 109920tatgatttcc taaaaataaa aattaatggt gagttaaggc agtatcctat agatgctgat 109980atagaaatag ggctaacata taatgatatg gtagaataca acgaagagtt aataaataaa 110040tttaattcat ataaaggata tattaaatat aaactagcct tacagcaaat taaggactac 110100tatgaatcag gtaaactaac tgaagagcag tacaaacaaa aaacggaata tattaaaaat 110160aatattgaca gtttcaaagt tatatagtat agtaacctat atcataataa aatagaggat 110220ggtattatgg agatacattt agatacatta gatttcaatg agttaacctt aaaagataac 110280aatggaaaca cacagacttt taatatccat gatgaactaa aacttagtga gtatacaatt 110340caagacgaaa tgtaccaaca gtcgtctaaa tttgcatggt gggcttcctt aaaagaacgt 110400gtgagtaatt atgccgaagc agagcaacgt aagttagaaa aaataggagc tcaacttaat 110460ctacaaatta gagctcagta cgaacaacag ggaaagaaac ctacaaaaga ccaagtagag 110520tctgctgtat ttctttctga tgaatatcaa cagcaagcaa aggttgtaga agcatggaat 110580tatagagaaa aacaattaca ttatatcgta aaagcttttg aaacacgtac aactatgtta 110640gtacagatta gtgcggaact aagacaaaca aataaaaatg gtggtgttac taacccattt 110700acacattagg tattgacaaa caaaagaaaa catgttatac taattaagta atttttaaaa 110760taaaaggaga aaagatatta tggattttaa tcaatttatt aatcagcaat cagaaaagct 110820acaatcaagt ggttttgaca atgaggtaga gacgtacaaa ccaaagaatc cggttttgcg 110880attaggaaag attaaggacg ttaacaataa tcaaattaat aaagagtctg cacttgtacg 110940tgtactaccg cctgtagcag gttctaatga gttctttaag gaatttagaa cattaggtat 111000taactatgtt aaaaaagacg gggcacaaaa gttctctatg cttactttac ccgagaaagt 111060taactcatct gttgtagacc cttatgtaaa tacatggtta aagcaaggtg tacaatttag 111120taacttccct aataaacctg cacgacgagc atatattcat gttattgaat actttaatca 111180aaatggtcaa ttagttccta acacagatga acaaggtaat gttgttattc aacctatgga 111240gctatctaac acgggtctgt ctcaattgat tgaccgatta aaagataaaa tgttatcacc 111300atcacctact gctacacaca gctttatttc agccgatgat gcattcccta ttaatattgc 111360taaagctaaa aaaggtgaaa aatcatggaa tgtaactgtt tatcctacag taaaattagg 111420tgccttacct caaggttggg aacagcagtt atcggattta gataagttag ctacaccaac 111480agaagaaaat aaccctaact ttgtaaactg gttgattaac aatgttaata acacagaagt 111540ttctcatgat aattttaaat tcagtagaga aacaaacaca ttaggtgaag aatcatcaac 111600acaagagcaa acacaagctc ctacgcaaca aagtgtagag caacaattac ctagtaattt 111660aggtggacaa aataacacac aaccaaactt taataatgta caacaaccaa caccacaagt 111720tcccccacaa caaaatacac agtttggtca aggaacacct gtgcaacaag caccacagca 111780accaacacaa caagaacaaa gtaatccatt tgagaacttt gatgctaata acattgacga 111840ttctcaaatc ccattcaaca caaatgaatc aacaccagaa ccacctaaac aaaatcaacc 111900taagagtgta gatgatgtat tagcaggttt agatttataa taactttata gagtgctatc 111960ttagcactct tttatttaaa tttcatataa aaggatgata taatggctag agcaaaaaaa 112020ggtaaagaag tagatactac aaatttaaat actattgact taggtaaaga attaggttta 112080actttactat cagatagtaa tagagcagat attaagaata tcattcctac tatgattcca 112140caatatgata gaattttagg tggaggtatt cctctaggaa gacttacaga agtttacgga 112200ttaacaggta gtggttacct taaatagcca caatggctta taatgagtta ttacaaatcc 112260acgtgaattg ctgggaagcc ttaaagactt gttaactaca acgtaactgg aaacggtaag 112320cgtgaatgtt aaaaataaca agtatatgag ttatatggta taacgagtta ttaaactgtt 112380atattatata gtgtaggtaa tcagcatcca agctcctgta aaatggagaa ggttcaacga 112440ctatcgaaaa ggtagctaat attgagaagt attagtgagt aactgagtag agtagggaaa 112500ccgaagtacg tgggaattgc ctacgaaatc tatttaaaat ggagagtagt ataatatggt 112560aaaacgagta tggtctaatg aagaaaaaca agatatagtg aaatcctttc aagaaggtaa 112620gaaatttagt gagatacaaa aaaagtataa tgcacattac tttacaatta aaaaagtatt 112680agatgagttt aatattgaca caaatagcaa gagaagatgg actagtaaac aaaaacaaga 112740tattttaaga atgtacactg aagagtctat gtctattgca gagataaaag cagtctatac 112800aacacatgca agagagataa gtaaaatatt aagagacttt ggtattgata catcttacta 112860tcaacctagg agagttaata gaaatattaa taaagatttc tttgaagtaa ttgatactga 112920agagaaagca tatattttag gtttattgat ggctgacggt tgtgttagat atagaagaga 112980aggtcaatgt tacttaacac tagagttaat tgataaagaa atagtagaaa gagttcaaaa 113040agaattgaat tcagacagta aaatttatga atctcataga aaaagagatt atataaaaaa 113100tgaaaattct acgtatactt ttagtgttac cgatgaaaaa ctatgtaatg atttagctaa 113160atatggtata atacctatga aaactaaaaa aacagattgg ttaacacaag acatacctta 113220tgatttaagg aaacattact taagaggatt gtttgatggt gatggttcta ttggatgtta 113280taataataat aataataata gatggtcaat aactttagtt aacaatcatc ctgaattttt 113340aaaagaagta ggtagttgga ttgaagactt attaggtttt aaatgtccta caatatctaa 113400aacttctacc tcttatagaa taggttatac aggtaaaaaa gctaaaaaat taatgaaaac 113460attatatcga gataataata ttcatataga ccgaaaacaa aaacttgcag accaagcaat 113520taaagatata gtctaagccc actattaagt tagtgttaaa gtactaggaa actaggggta 113580gtaactgaaa tcgacctttg cagtacactt atctagagta gcaacacaat taggagttat 113640tacagtttgg attgacattg aaggaacagc ggataaccaa cgtatggaac agttaggtgt 113700agacgtatct aaattgttct caatacagtc aggtgaaggt agacttaaaa atgttactga 113760actatcagta gaaaccgtag gtaaagagtt agaatactgg attgatacat ttaatgagaa 113820agcaccaggc gtacctattt tgttcatttg ggattcccta ggagctacac gcacacaaga 113880tgaaattgat gcaggagtag accataaaaa acttggaacg aaagcgacaa gtacacaaaa 113940agtagtaaat gctatttcac ctaagcttaa tgatacaaat acaggattaa ttgttattaa 114000ccaagcacgt gataatttaa atatgagtaa tccttatgat gaccctatta agtctacagg 114060aggaagagct tttgaacatg gtgctagttt acgtattaaa gtatctaaag gtaaagaatc 114120agaattaaaa cagaatgatg ctatgacagg taaacctacg tataaaggtc atgttatgcg 114180tattgaaact aagaagtcta agctatctag acctggtcaa aaagcggaag ttgatttatt 114240atcaggttat gaagtaggtt ctgatgaaga tactattcaa ttaaacggtg ttgaccctta 114300tcatactatc tataaagaag ccgttgagcg tggtttaatt actaaaggaa catggcgtaa 114360ttatgttacg ttaaatggtg aagaaattaa aaaatatgat aaagattggg taccgacatt 114420aatggacaac catgaattat acttagaatt atttagtaga gtttaccacg agaatttccc 114480tcataagtat gcacctttaa acaatacaaa agtagacact actcaattag aagagtttaa 114540agcattacaa gattactacg aagagcttag ctctactaat aaagagacta aggaagatgt 114600aaatgaataa tctaatagat agaaatatta atagtgttaa agaagcatta ggtagggcta 114660atacaaatga tgtattgccc ttaccttata ttgaaatagc agaacgtttt aaaaaagcta 114720gagataataa ggagcctatc attgtagaag agtcgggatt tccttacact gattctacag 114780ttatgtatat tgagcatgta gagtcaagat gggcaggagg ttactcttta gtacgttata 114840atagttctga agtcaaagta cctaaaacaa tacattattc cgatatctat gtatcaaatg 114900atgtacacag gattaagatt gtatttgagg gagcacatcc ttatgaagaa agttaataat 114960gggaatagat atattataga cttagatggt attcctattg actttggtag agacttagac 115020atgcttttaa agagatataa aaaccttaga tggtcattat ttcataggta ctctagaggt 115080atgagtcatg actttgagaa acaagagcta cgggaataca tagatgagca gtttattaag 115140ttagttaagg agtatgatat acaaagtaaa gtagattttc cagggtatat taaaactaaa 115200ctaacactac gagtacagaa cagttatgtt aagaagaaca ataaatataa acgtactgaa 115260cttgtaggta aaacagatta tacagtagag tccttaacac aggagttaaa tgtgggatta 115320gaagaaaatg aattacttaa ttatgtcttt gatgatacac aatttactga agtacaaagt 115380gaactgctaa aagagctcct tattaatacg gataaagaag acaacgcatt tattgtgtct 115440actgtagcta ataggttaga tgtagaacgt tcagaagtat ctagagagct tacagaactt 115500aaagattatg ttaaatttaa aataaatgct tatcacgaac aaaacagtag aagatacatt 115560agagacaaca aaatagatac acaaaatcat gtatgggaat aacacaaaca agccttcctt 115620ttgttatatt attaatgaaa ataataacat agggaggttt tttctatgtt ataatgtaaa 115680aaataatgat tggagattaa ttattatggc taagaaaaat attaatgaag tattaaaaca 115740agataccgct actgtagcag ataagtattt acaagttcaa gtagagcaag atggttatac 115800acgtacacac cgtggtcagt ataactacaa agtagtagat aataagggag aattattctt 115860atacccgatt gaaacagatg gtagaggaaa tattaaaatt atgaaaaagg ctcctgttgc 115920ttatacagat ggagaccaaa ttcattttgt agttaatact gttaaagacc cttacaacca 115980tgcttttatt agaactgaaa atattaaagg taaagataaa ggtaaacaat taattcaagc 116040gtttttagca ttcgttgaag accgtttcag ctttggagta tacaatgtat tccttgctaa 116100taacaagagg gatgtttttg ctttagttga tgctgaaagt aaagatgcta aaaaagtagt 116160agatagtaat gagaaacctc atgaagacgt gagcgctgag tttcctgcta gtccactacg 116220taaagacgtt aaaggagtag actcaggaga aggtcaagga gatacttcag aaccgtcagt 116280acctaaaaat gtaacagtaa cagctaaaga aacaacagct gatattacag ctgaataatt 116340atataaagga tgacttagtt tggataaatt aaatttatat aaaggtgacc agctattaaa 116400aagtgaagag aaacaagcag gtaaaacatc aattacaatt gataacttaa ctgctaacac 116460agactaccca caaggtacat ataaagtatc tttctctaat gaatcaggag aatcagaaaa 116520agtagatgtt cctgcgttta agactaagga cattaaagta gtatccgtta ctttagatgt 116580agaaacacta gatttaaaag taggagaaac acataattta gtagctacga ttgaacctag 116640taacgcaaca aaagctactt atacatttac ttcagaacat gatgatattg ctagtgtatc 116700aagtaaaggt ttagtagaag ctaaagcaaa aggtcagact acaatcactg ttacaactga 116760tgatggtaat catacagata ctgtaactgt agttgttaaa gataaagtac ctgaagctcc 116820tacaaatgta actgtagacc ctaaagaaac aacagctgat attacagcat aatcggaggt 116880aaaaataaat ggaaaaaaca ttaaaagtat ataaagatgg tgaagtagta ggtactaaga 116940ctgctgaaca aacaggtaaa acaactattt ctattagtgg tttaacagca gatactacgt 117000atcctaaagg aacttataaa gtagcatact ctaatgagtc tggtgaatca gaaaaggtag 117060atgtacctga atttaagaca gcaccacata gtgagctata ataaattaaa gtccaactta 117120attgttgggc ttttttttat tgacttatat ttatttatat gctatagtta aacaagaatt 117180aataaaggag gtactatatg gatattaaaa cagtacactt aacttcagat aacgaccatt 117240tgaaagttaa aaaattaatg gaagataagg aaaagtatat tgcagttgcg tatgataata 117300aatcagtaag taaggtcaat atcattatgg ttattaatgt tattaaagac ctagtgcata 117360tgtataggta taaaattgtt gagtatggat tatctaataa tgataaggaa aatgaaaagg 117420tagggtattt aatagaaagg attgaggatt gatgttattt attttaaatg aagtagcttc 117480acacacagaa catttatccg aaggtataga tatgttcgac gttgaaagtg tagtatcttt 117540tgactcggca ttacatttag ctagtgataa tacgtatgat tctgttattt ttttaggttt 117600tatatacaat aatgaggatt acttaaagta taaagaatta ttaaaggata caaaattata 117660ctttgtttct aatattaact tacccgataa caaagatttt attaccgtag gtgatgattt 117720aaaataccta tccttattag agcaacttgt ggttctagat gacaaaggtt taaatattaa 117780tttcagtagt tatacaaaag acattgctca caagtacact gagttgttta gctttaaatc 117840tacttatgag gaggcaaaag aaaagggtct agtaggttac cctgtagata tagtattacc 117900tattatgact gacaagtttt acaacgtaaa tgatttgtat gtactatatg aagtagcacc 117960tgagtataaa ttacctttag catatgaatg ccttaaggat aaagaaaaag gtattgttgt 118020tataggttca caaacaagag gtactagtga tatccttact ttctatgtaa aagggtatga 118080tgtcagtagt gttgctaaaa cgtttggagc atcctataat gaaaattcta atatatttag 118140tatctttatt gatagtcata ttagtgtatt aggtgagaat atgaacaagt atttaataac 118200ggaaggatgt atttatgagt aattataaaa caatagaaga gttacaagca attattgtag 118260gtattttatt taaagatgaa ggtaaggtag ttacatctaa atttaataag attctaacaa 118320gttttggtat tgatagagta aaccgtaatg agttaaaaga cattgtagaa aatattagaa 118380gtgatgagta ccttaaccaa ctaaagaata aagctgttaa aggtgaagtg ttattagaag 118440acttaagaga tgtagaagat aaacaagtat ttgagggtaa tgactatcat caagaagtgt 118500catcttatgt agtagcacat gaaaaagaac tatctagact aagggaatta cgaaagatta 118560atagacaaac tgcataccct actattttgt ttgatgaatt aaagcgtact atggttaatg 118620agctaaaagg gaataagtta ctagaccata aagtaagtaa gtatacttct actgaggaag 118680aagaagagct ggttatctta ctgtcggact tccatgtagg ttgtgctttt caagatttaa 118740ctaatgagta taactttgag gtactaaaaa gaagattaaa tcagctacta caggaaacta 118800ttaaggatat tagtaaacgt ggtattagta atgttacagt atactttgta ggtgatttaa 118860tagagcatat taatatgaga gatgttaacc aagcttttga tactgagttc actatggcag 118920agcaggtagc aaaaggaact agactattaa tcgacttctt aacagaatta tctccatatg 118980tatggggtaa tttacgtttc ggtatgatag caggtaacca cgaccgtgta cagggtaata 119040agaaccaaaa agtatacaat gatagtgtag cttatattgt attggattct ttactgctgt 119100taaaagaaaa cggtgtatta gaaggtattg agattatcga caatagaaaa gatgtatata 119160ctattaaaga cacagtatgt aacttaaata ttattataaa ccatggagat ggacttaaag 119220gtaaaggtaa gcatattcct aaatttattg agaacactca cattgatttg ttaattacag 119280gtcatgtaca ccacttctca gtaacacaag aagattacaa tagaatgcat attgtagcaa 119340gtagtcctat gggatataat aattatgcta aagaactaca tctatctaga acaaaaccat 119400cacaacaact actattttta aataaaaaaa ataaagacat tgacattaaa actgtattct 119460tagattaggg agagataata tggacattct atcaattata gccttaacat tgcttatcat 119520tattattgtt aataccacaa tgaactttgt aggtatgtta cgtggtgagc gtgaattagt 119580aaaaaaagga ggtaaccctc tacccaattg gcagtactat aatgtgttat tacctaattt 119640atgtggtatt atcctcttag gtattgttgt ttattttgga gattcgattt ataaaattac 119700aacaaggtta gaagttcttt ttgctattat tgcgcttatt gtaatagatg tattgttaac 119760agcgttagta ttattagtat tgagtttcgt aacaaaaaat aaagaatagt aaagaaggga 119820gtctggttta tacttgactc tctttgttat ttatggtata ttagatatga ggtgattttt 119880gttgcaatta aattttggta aatttgataa tgaaattatt aagacaaaag taagtgaagg 119940tgtttactct tttagaggtg ttccttatta ctacatagaa catgtccaag atgaaacttc 120000tgagtatgta ttagtatata acatacatag tgttgatgat gaggtaccac aaaagaaata 120060taaaatagaa acagtaagta aaactattag aggtggtacg atattaagta atacaattaa 120120gtcaatgcta cctaataata agaagtataa aaaagtatat gaacctccta tctttttagc 120180taatattata cctttaggta cagatacaac tacaggttct gtaggtaaag ggtttttcga 120240aagagaaaaa gatagagtaa ctattacaca aaaagaaggc actaaagtta tacatggtga 120300gtatacagga gtatttatat gtttatctaa tgttaaatgg attaagtctt atacaccttt 120360agatagtata ttacaatatt atcaacgtat taaaggggat agaataaatg tctgagataa 120420ctaaattcta tgagcaggat attaaagatt

taattagaac gaagagacac atgtttaaag 120480atgatgagat aacaagtaat atacaagata ttagaatatt taatgaaaaa gctatttgtc 120540aaggtaaatg tagaactgac tgtttaattc ttgatagaaa tggtactgtt atgggtatag 120600agataaagac agaacgagac tctacacaaa gacttaataa acagttatac tattatagtc 120660tagtatgtaa gtatgtttat gtgatgtgtc atgataagca tgtacctaaa gtagagcaaa 120720tactaaaaag gtataaacac catcatgtag gtattatgag ctatattaac tttaaaggca 120780gtccagtagt aggtaagtat aaggaagcta cgccttcacc actaagaagt ccttatcata 120840cactaaatat tttatggaag caacatttaa tgactatact taaacagtta agagattata 120900atacatacct aactggatat aactataggg agcacggtaa aaatactaac aatgagggta 120960gttatacaga gggaacccaa cgtatgagaa tgaaaaagtc agctattatt aaccaagtta 121020ttcattactt aggtgtagag aactcttata agatatttac tagaggtgtt atctatggtt 121080acagtaatag atggcagata ttagaagatg atttctttaa agttatacag aacggagtga 121140gggtattata tggcaaagag gaaacctgat acatttaaac ctaaatctaa cggatataaa 121200catcaacctg ttaactttgc tcctacgggt aacttatcag gtagaagtac ttcttttttt 121260aataaaaaaa gaaaagatat atcagatgaa agtattgttg ttaaatacaa acctttgttt 121320gttaaaaggt ttgataatat tactgctaca gacattaaaa tacaaaagaa gtatgcgtta 121380gacttaatta gtgaagctgt gaatataaag aagaaatatc ttgtaatgaa gcaaaaaggt 121440aaattaacac aaactatttt acatacggat agagtttatt atgtttatag aggtaagaaa 121500ttaataggta aatgtagtat tcgtgaacaa cgtacattta gaggtacaca tttaatctac 121560atttttagta ctagacatag aatatctata cgcaaaaata gtagattaga taagaaaaga 121620acaccaaaga aaatgatata taaaggtggt aaataatggt taaatattta agaacaaaag 121680ctaaaaaaac aaatataagt actttattta agaaactaca aagtaaagat attacactat 121740taggagtgtc ctatgatagt gattatttcc ctagcggtgt aacaataata ccttatttag 121800aggacatatc acaagtagaa gatggtatag aatttacgaa taaagtaata gttactgaga 121860acttaaaacc tgctattgta ggtatgaata atatgataag tgattcagga ctaggttatg 121920ttaaaacaga gcagttaaat aaaagattag aaaatactgg attaatgaca gatttattat 121980ctaaaggaac agaattaact tcaacaaaga aagtagacat tgtatcaact tttattgaac 122040ctactattat gtaccaagat actactatta ataaagaatt aaaacttaga ttatacacta 122100tcgaagatgt atccccttta aatgattaca cacatgttgt atacttacta gtaactgata 122160agcaatatga cggtcaatca ttcataggta cattatgtaa ccaaggtaca ttaaacaaat 122220tagatactct aaaagttctt acattcttca agggtaataa tttaatcaat agaagtgtgt 122280tttctgttaa gttagatacg aataaatatc attatagttt atataataca catgagaccg 122340gtattttctt tttagatgat gataaagact taattattgc ttgtggtcaa tcctatgtaa 122400aagttagata taaagatatt gttagtagta aagtagagaa agttagtgat aataactata 122460aaatgattgt taatcttgtt ggtaatgatg agctaacaat tctcttatag tataatactc 122520ccttaaatat gtatactaag gtataaatat acgtatataa gggatttttt atacatattt 122580ttttcaagta gttagttaat ttctaaaagg tattattctt attttaaaat tatatttata 122640aaacattaaa atacctttta ggtatagggt tttagaaaaa agatttatat tgcttaaaat 122700agttacacta tagtgtaaaa aattagaata tcctttatga aaataaaata gatgcagaaa 122760ttgtgatata ttatatagtg taaagtataa aacagttgat ttgataaggt tatgtgaata 122820cacatactcc ttattttagt tcacacatat gtaaagacac ttgagacaag aagggaatat 122880ataatggcta gaaaaaagaa tttaagaaat aaaaaatctg atataaaggt agttccagat 122940aaggaaagta ttctatctaa actatataat aataaactat taaggtctaa agtggataat 123000gctatagatg aagatgttag ttatgatgat attatagacc tatgtaaaga gtatgactta 123060gagttatcca aatctgccat tacaagatat aagagtaaac gtaaagaagc tattgaaaat 123120ggatgggatt taggggaact tattgataaa agaaagaaag ttagcgctac tcaaatacag 123180aaaaaagaaa atcctatgaa agaattagat agtgagaatt atacaccttt tgaactggct 123240acacagaatg tacaaacaat atatgatgat attcaaatac tagatatgat tattcaaaaa 123300ggtgctaaag gtttaaactt tgtagaaaca ttagaccctg ctttaatgat taaagctatg 123360gaaacaaaag atagaattac gggtaaccaa ctaaaaggta tgtcattcat aggactaaga 123420gaactaatga ttaaacaaca agcacaagat actgctatga cagaagttat gcttgagttt 123480attcctgaag ataaacatga agaagttctt caaagaatgg agcaactaca agaagagttc 123540tataaaaact tagatttaga tgaagaagga agaaagttaa aagatacatt agatagagta 123600ggctatacaa tatagataat gaggtaatac atatgacaga agaaattagt ttaattccaa 123660taaaagatgt taaaccactt acagatatag tagatattat aacacaccta tataaaggtg 123720atgtacttag agttaaacaa gagaaccaag gagatatatt acttagacta agtactggaa 123780aacataagtt tactgaagtg tcaagagact tagataaaga aaccatgttc tataaaaggt 123840attgggtact atacaatgta tctattaatt ctttactaac ttttgatgtt tatttagaag 123900acgattatgt agaatctaca aaagttaagt tccctaagaa cacaattgta gaatatgtaa 123960gagataatca agaatcagat gtagctaagg ttaaagatat tttagtagat agtaacggta 124020attatttcta tgcactttca ggagaaacat ctttatataa tgaagataaa cttaataaaa 124080ttaaaagtta atgattgaca cactcatatg ggtgtgttat tcttttatta caaacaataa 124140aaggagcaat tgattatgat tattacatta aatgaagaag agaaagcatt attagaaaat 124200aaaagcaact atacgccatt aagtaagaat aaagagttca atacaccaaa agaagaatat 124260attgttacaa gttataataa aggtgtacct gtaactgata ttgccaaaga agctaaagta 124320agtatgggtt tgatttatac agtgttaaac ttctataaag tacctaagaa acataagaaa 124380tctagagtag caaaacgtgt aaagcatatt actaatgata agaataaagt acaagcctta 124440attaaagatt atcaatatat ggacttacaa agtatctata aaaagtataa cattcacaag 124500aatggtttat actatatttt agatttatat aatattgaaa gaaaatcaga tttaaaagag 124560aaagccttag aagatactat cgaggtagaa taagaggtgt catatgcgca aagaacgaat 124620tgtagattac ttgtataatg taaagaacat tgataataat ttaactatac aaggaataga 124680aaatagttta tttaataaag aatctctaca agacttagta cctgattttg atacttctag 124740taaagagatt aatgaaagta atttatacct atgtacaata ccagaagatt ataactccga 124800ccatgtagaa agtggtcagt atataggtat agatgttggg tatgtatctg aagaccctgc 124860ttttgaccat ttaataggtc aagttcctag aagtgtatat gagaaagcgc atgttatgca 124920accactaatt aagatagaaa atactgatat agattatacc caggctgata tgattaatga 124980tattaaagta ggtacaagta ttagtgatgt aaagattaaa gataaattaa gtttaatgtc 125040aaataatctt attacacatt tagaaattgt tgataagtat tactttgata gtagtataga 125100agaagcacta ctaaagtatt atgagttaaa aaatcctgac tattatttaa aacattttct 125160taaactaaaa gaacttgtca gagacaatag aatgatatat tgtcctttac tgttaaaatg 125220tattaaagtt atagactaag ttattatatt ataagtagta aaggatggtg cgctatgagt 125280aaaaaagcaa taattgctta tgtaattatc ttagttatgt tagctttatc tatatctact 125340tattacgtat cctcatactt atatcatgaa aaaaccaaat cacaagttac agaccaatta 125400acacaccacg gtaaactaaa aaaagataag aatgtagagt atgtagggga ctatacactt 125460aagaaagtaa tagacaacaa agcatacttt atggaaaaac tacctaccta tttaccagga 125520agaacaagtg ataaaagtat tgatatgaga tattatagga ctagtaaatt tagagaaggt 125580gtaaacttta aacttattcg tgtatacaca gaggataatg acaataatcc agtacacaaa 125640tataggtttg aggcagtatt aaataaaaag taaaggtatg atagtctatg accgtagtaa 125700ttatactagt atgtattgct attatatact atttatttaa caaggattga gtcaagttta 125760tacttgactc tttttttatg ctatgttata gtttaaatat aaggagatga taaatgatga 125820aaaaaagtga tttagataat ttgtatattg tggtcgtaag tattaagaat ggtgttttac 125880ctgatgagcg tgtaattcca attggtttag atgtactaag taaagtatta gagggtaaaa 125940ctacatggac agttaagaaa gaaattaaac atacatttgg taaagatgaa ttaaaaagat 126000ttaaagataa ttacaagttc ttgcaacata aaattgtaga ccttgctaca caaggatata 126060ggtaggtggt ataaatggat atagtagata aactcatgtt aggttttatt ttattgtttt 126120atgtaggtgt atttatttgg tacttatggg aagtctggaa attaacttct ttaatatctg 126180atatagttat taagtattat gttcgtaagg gatgggttaa aggtttatta ccttatttga 126240ttcatcaagt tattattacg ttagtttggg ctactctagt attagtacct tttatactta 126300gttatataat gataaaatat ttgataggag gttactaaat ggaagtagta tatgagaatg 126360aatgtagagg atattatatt tgtgtcatag ataatgaagg taagtatgaa gtatcatctt 126420ttaaaaaatc agtaaacaaa tatacccctg aaattatagg gtatactaca gaaaagttac 126480tcttggaatt aaaaatacca tgtacatatg taaatgctag tgaagtagaa agttttatgc 126540aagaattaaa agtagcacgt attgcgcttg acaagtttac taaagattta tataataaag 126600gcataacaaa tattatattc taaagggtgg ttagtatgta tacagaaaaa tatagaaatt 126660taatccatat tacacatagt atcttggtta gtattcaaga attagcaagt aatttattaa 126720ataaggaagt aaaactagtt acaaaagaaa ataagtactt atgtgttgta gatggtatta 126780ttatgttaat tgttgaagaa gggttagtat acacctattt tgataaggta ggtttaaaag 126840tgcctgaacg tattgcactt ggtcatttag caaaaagttt acagtttaca atatcagaat 126900caaataaaga tttagaaaat caaaaataag tgttgacacc tttaacatgt tgctttatac 126960taagagtaac aaaacgttag aggtgatttt ttatgtgtaa agaaaaagtt catagacagc 127020tatctaatgc tatagaaata ttagcaactt acaaagagtg gtggtctttt ccaaaagaat 127080taagtaccac agaaacattt aagattatta actggaaaga agatacatta gtatttgaag 127140ttagagataa cggtaattat ataggtaggt ttagtgtagc aactcctatt attgactttc 127200attatgatag aattaaaaaa acgacagcac aatacatgat aaattatttt gctaaactag 127260tatgtaaaga tatgtatacg tattataaat tacagagagg acagtaaaaa tgaaaaattt 127320aaataaacag aaacgcttga cgttggaatt gattagtgat aatctaaata cacaacataa 127380cttaaataca tcggttagtc ttgtagatta tagtataaaa gactttacaa atagaaaagt 127440gtatgtaaga actaaaaaag gtttagaact tactaatatg aaaagtttaa aaagtactga 127500gtcattagat ttattattta agtatctaga attaatttta aaaggagatg tataacatgc 127560taacaccaga acaaagaaca caattaaaag aatatcaaaa taaaatgaca aaaaagaaaa 127620aataaatgtt gacttactaa ataacaagtt gtataattaa cttaacaaag aaaaaggaga 127680ttgataaata tgaaaaactt atataaaatt ttaacaggag tattctttag cactacacta 127740ttattaggag gttgtgctta ctactcacaa gaagatacac cgacgcacaa ttataaggaa 127800gacaagaaag aaaataagaa agatgaaact tcctcattag aagaacaaga gaataaacaa 127860attaaagaag acaacactgt tcaaaataac caacaagata accaaacaca aggacaagat 127920aagactcaag ctcaacaaaa tgaacaaatg caagaagcaa gtagaagtga acataatggt 127980ttatctaatg ctgagtatgc agacaagtat aatcaatata gggaagctca acgagcacaa 128040gcagaattag agaatagaac tgaggcggat aaagctagcg gtggtggagg cggaggagcc 128100tcatggaact atgcaggagc taatgaaagt tttgaacaat ggttacaacg ttcacaacaa 128160gaaagagcag aggcaggatt acaataaaat taataaaaga tacaggagaa taagtatgaa 128220aacaataaca caggaagaac taaataaaat tctagtagaa cataagctag cgtaagtaga 128280tacaaggatg attaaatatg aacattgtag aacaacgaaa acctataaaa agtaagcata 128340ttaacctaac taaacacgcg tatgaacgtt ataccttaag agttagtaac gatagtaaag 128400aacgtgcttg tcagtggttt gctagtgctt taatgcaagc tacttttgaa catacacaaa 128460aaggcggtaa tgaagtatat gtatttaaaa attatagaat tattattgat aagcatctaa 128520ctattattac cgttatagat actgaagatg ataattggga aggcataaag gaagcaagag 128580aacaaataga tacgtatatt aaaggtaagc taaaaagaac tgttacacct ctatttacta 128640agttagatag aatagatatt agtatccatg aagcacatat cagcatgatt aaaacaagaa 128700accctaagac aaaagatata attaacaaaa atattgttga acttgaaaga aataaatctt 128760tactattaaa tagtatagaa ggtgtaaaga aaacagcaca taagtattat gtagaattaa 128820aagacattca taaaagatta aaggactgat aataatgtgt ttaaaagatt taattgaaga 128880ttatataaat caagataaag aaataattat aacagttaca agtactaaag taattattga 128940ggcagactat gatgttattt gtttacctaa aagtaaaatt gatattgacg atttaaaagc 129000ttatgtatat ggatttaata gatttaatat agagcaaatt gtattaaagg acgtggaata 129060atgcaagact taaaaaggat aacacaacct gaattagatt tattgataga aaagcatgaa 129120caatggctag ctacaaatga aaaggaagga gaaaagcttt ttttacagtg tgtagattta 129180agaaatcttg actttcattc cgctgacctt caatattcaa ctattgtaat gtctagttta 129240agtgatgcta acctaagtta ttgtgattta agttattctg atttaagtta cagtgagtgt 129300atatctacga gatttacaaa tgctcgaatg aaagatattg agttgcatca tactaactta 129360gagtgggcta atttagtaaa agcaaactta gaaaatgcct gcttagctga agctaatgta 129420agtgaggcag acgcaaggtg ggctaacatg aaaaatgcta acttaagtat ggctaattta 129480aaaggtgcag attttggtgg tacaaaccta actaatacaa cattatatta tgctaacatg 129540cttgacgtgt ttgggataag tatctatact ataagtaatg tacttgattt tgacgagcat 129600gtaacttatt tacctgatta tgatagaatt attagtaatt ataatgaata tacccttgaa 129660gagtttggta aactagaacc tacacttgag tacgaagaag atagaataaa agaagtctca 129720aagaaaatta aattagctta cgatttcttt aaaggagtga aagaacttga taaaatttaa 129780ttcagacgaa cataaacata tacttaatgt tatggataga ttaccatata tttgttggtt 129840agatactgta gatggtgagt caggtgctga ctttttatgc gtatcgcata gaacacacta 129900tgaacttact gaactaggta taatgattta tagttatggt agttggtata tgatacctta 129960tgacaaagaa gatttaattg aatatgcaat aaaaagagat atagaggagg aaggggaatg 130020gtaggtatgg tgattacatt tttaattgtt ttaggtatta tattgctaag tgtactaatt 130080attgttatac cagatttaag caaagcaaaa aaacgtaaag aagactcaga tattaactat 130140aatcaatata ctaaagacat ggcttctgag tactatgaaa agtatataac acctaccgaa 130200cacattattc aaactaaagt agaagaggta attgaaaata taaagaaaga atataatgtc 130260tctactgtaa ttattgactc ttctagtaat gaagacaaaa ttatcttaca tgttaacgat 130320aagtacttaa aaaaggtagt gtataaagat acgtatgaat acatctacga ttctaataca 130380aaataccaat acattattaa taatgtaaca tatgagtcga gtatcttatt aaaacaagat 130440gaagtaaata aattaaaaga tatacttaat aaagtacctg tcacagctaa gcatacattt 130500aaaaatgagt tgcttaatcg taggaatgaa tatgtgttag gttatattac aatatatatt 130560tatggtgact taactgctaa aattacaaag aatggttatg tacaagactt tagtacacta 130620gaagattttt gtgataagta tgaagcttac tgtagatttg ttagaattga tttatatgac 130680tgggtaaaag aagtaagaac tattaatggg tataaattaa aggtagatat taaaccttat 130740tttaaaatta ctgctactaa aacaagtaaa tacgaatttg tagtaagtga tgatgtatct 130800aatgttaagg tatatagaga tgatatacta ctaacaaaca ggtatgtgca aaaagcaatt 130860gatatacagg aaatagtaga ggaaacattg aataataata ctgtggtatt ttaaaaaaag 130920ggtatgaata atgaaaaatt taggtaaaat tataaatatt attgaaagag aatgggatat 130980taacatagat agagaatatt tggcagatat ttattataat gaagttgaac aaggtagaaa 131040taaagcaatt agtacgctaa aacgtatact agaaagagat aaagagttat caaagtacta 131100ttatgacact tttctagagg cattaaaaaa gagagacatt aaaagagttg tatcttattt 131160taaataaatt ttataaggtg ggagaataat gataattcaa aagacatata cttgtaaaga 131220attaatagaa aaatacttta atggttattt aaaagaaggt acttacacag gtacatccga 131280tggcttagat acttattacc ttctgttaga aaataaccgt atgactattg gatatcaagt 131340acctttggac gctagtttta tagtagaaga agaaattact aatgacacaa aactagaaaa 131400ctgctgggta ttattaaata gtcatgcaaa agaactattc atggataaca caggtaatgt 131460gagtattaat gattgtatag aaatatacgg agatgaatta ttaactgtca gtatcttaat 131520cgatggtacc tttattaatg tatggagaaa tgatgattat tttaatagag gaggagaata 131580atgaaaacaa taacaaaaga agaattaaat aaagttctag aagagcataa attatggata 131640gaaagcaatg aggaagaagg taaaagagca gatttaagtt ttacagactt acgtgaccta 131700gatttaaagg atgttgattt aagagaagct accttaatag gtgctgattt aagttatgta 131760gatttaacag gagcagattt aagatatgct gatttagcgt gtgctaaact aatagaagtt 131820aatttaacag aagctatctt agcatatgca gatttaagtt ctgttgattt aataaggtct 131880aatttaaaaa atacccattt aacagaagct aacttaaaag gtgctaattt agtagatagt 131940gatttaacaa atgctacttt aatagaggct gacttaaagc atgcctcctt atcaggtatt 132000aatttaataa gtgcatattt acaaaatgct gatttaagat tttcttattt aagaaatact 132060ggtttaatag gtgctaactt atctcaagca tctactcaag gtattagagg tttagaaatg 132120tattctatag ataatattgg tagttttaaa aataaagtaa cgtacctacc taaatataat 132180aaagtatttg taggatgttg ggaaggaaat ttagaagaat ttctaaaaaa aggattagaa 132240atgaatgaag gagataataa agagcgtacc aacattgtac tagcttatca gttctttaaa 132300aaccagctat aataatttaa gtatgagtat ttcttagtaa gtaataagta ggataaaata 132360tcctacttat ttcatatata agtgttgaca tgaataagtg taaggtttat aataagtata 132420taagttaaat aattatagag gagacattaa tcatgaaaaa aatattaagt ttagttttat 132480ccgtattaat tgtactaaca ataatcaatg tgttgaaaaa ccaagagcaa gtagaacaaa 132540gtaaccaaga acctaacaac caagagcaag tagaacaaag taaccaagag tctcaaaata 132600atgatgcaga tgaccatact tcatacgtac ctgagaataa cggagagcat aaagacgtta 132660gtgaagaacg taaaagatta tggggtacag agtatcaaga aggtgaaaca cataacccaa 132720atgctaaagt gtttaatcaa gatacaggag aacaggttca ataaagagta agaggagcac 132780ttattatgga gtactggaaa gaacaagaca tatattattc aaaaacaaaa caaggtgtta 132840taagctatat agacttatct tccttaccta aaaagaagtc tcgtattgat tgggtaaatg 132900taaaccatta tatacccttt gagtatcata gcacgaaagg taagctctat attaaatacc 132960ttacaccaac taaaaaagaa tctagagtag aaataactta caacaataaa atccaagcta 133020cccaagtagc taatgtctat aaggttaaat tcaactttat tacccaaggt cagaagtctt 133080atactgttca taatataaaa caaggagata ttattaaaaa ttgcgaagta ctaaaagtag 133140tagacactca tttaggtaca caactttatg tatataacat aaaggaagaa gtctatggta 133200aagtagtaaa caaaatttac taaaatataa aactgataac tatataccat atggtactat 133260tcctcaatct aagatgttat accataagaa acatattcat aagtatgcta aatataaaga 133320cttatttaaa tataagtata caactaagaa aaagatagaa acgatttgcc ctaattgtaa 133380aagaaaaaaa gatattagaa ttacagattt aattaaagat aactatagct gtcaatgctc 133440taaacaatac tctagcttcg gagaaagatt aacacaaagt tatttagata ttgcaaacat 133500agagtatatt agagaatata aatttaaaga attaggtaaa aaaagatttg attttttctt 133560acctaagtat aataccgtta tagaagtaca cggtgttcaa cattaccaag aagtcagtgg 133620atacatgaac caccagaaaa caaaattatc agacatagaa aagagagaat attgtaaaga 133680aaatagtata caatatatag agattgatgc tagaaaatct acctttaaac atatattaag 133740taacctacaa agaacattta aatactctaa tatagatagt aaagaagtaa ttaaaagata 133800tagacatgta tataggtaag tgtagaagag taaacaacca aacagacaaa caaataggta 133860tagagattga tgtaggtaga agttatataa gtaagtaata ggtaaaagaa agcaatatat 133920atatataagt agataaagaa atcagataag taacacataa agaaacaact gatattataa 133980gtacctatat atcaaggaaa taaataatag ataaaaaaac aataattgat agcacataga 134040taagcagtag gtagtaggta gtgtataagt aatagctaaa tagataagta aataaatact 134100gtataacagt ttgaagatat gaataataag aagaaagaat tattaagtaa cttaagtatt 134160aataaatatt ctaatagtaa gtaatagata ttaagtaata ggtaagtaac taaaagaaag 134220taactaaaag aaagtagcta ccactatcac ttaggttagg taagaacagt tacctagtaa 134280tttctttaca tcttctagat agataaataa gtagatacta agtaatagct agtaagtaat 134340taaaagaaaa caggtacatg gtatacctat atactaagta gcaagtatca agtatcaagt 134400atcaagtatc aagtatcaag tagcaagtat caagtatcaa gtatcaagta gtaagtagta 134460agtagtaagt agtaagtatc aagtatcaag tagtaagtag taagtagtaa gtatcaagta 134520tcaagtagta agtatcaagt atcaagtagt aagtaagaac agttacctag gaatttcttt 134580gcttcccacc ttcatagtgt ataaatagtt aggtatctaa ctgttagata cctaactatt 134640tatttttata tagttttaac tactgtgaac tatgcttatg tagtattaaa ctatgctgat 134700tatatgctaa actattctaa tgtatagtta aactaagctg aagtagtatt tactgtgtat 134760aaaggtatat ttagtattag atattgtgta tatggtatac tataattctg aacattactt 134820atttaatata tatatatagt ttgtttctat ggtagtattg acttaatttt ccctagagta 134880aaagtttaat atatttagta atttccgaac aataaagaaa ttttaactat tttacacata 134940tgtgttgaca gtatattact tatggtttat actaagtata taaagttaaa ggagatgatt 135000tatcatgaag attaaaagag aagtttcgtt tatagaatta atgtatatgt attataaagg 135060tgatgtaggt aaaggtcagt actattctac taatagtcag tttattgttg ttataactgt 135120tgatgatata tcgttttata atgcattgta ccctaataaa tctattacta ttactatacc 135180taatgacact aagtttattg tagaagcggt tatagatgct tctactgagt taagtagtat 135240agtagttact tataagcaag gtaacagtgt attaaactca gtatggtata ggattagtat 135300taatgaagtt attgactact atgtcgaagg taaaaataca tggttactat ctgttagtac 135360tgttgtagat aatgagttag ttactatatg gaaagatggt aacgtattgt gatttggtat 135420atagtaatat tcagtatact tatatatgta catcacttgt attattatgt gtagtactag 135480tatatagagg ggttaaataa ccgcttcaat

aaagacttag taacgaggag ttgtattatg 135540agtttatcag atatttatgt acatttaaat cagttaggat ataaaataga agttttaggg 135600gacatgagta cattaaaagt taatgactac tacatcgaaa atagatgtat agatagtggt 135660tttagggtta caggggataa tgtattttta tctgtatatt atggtgaaga cgtagtaaga 135720ttctttaaac aaaggttatt aaaatagtat tttgttaagt tatacttgag aataattata 135780aaggagggat tagtttatga gtatatttat aagtatagtt tctatatttt tagctactat 135840tagtattgta ctaagtataa ggtttggtaa gaagtattat aagcatgtac ttgataatta 135900tgatagtgtt agtgatttag aatcagctag tgtatttggt ttattattta tgagtatttg 135960tattggtact atttctattg ttttgagttt aggttacata gtaagtagag tattttatta 136020tataggaggg ttgtagatga tgagttcaac tttaatgtat attgcggtta gtattttagg 136080tattagtatt atagttggta tgcttagtgc tttaattact gatatagtta aatctattaa 136140gcagaaagaa gtgtttttta gtatatatct tattgtttct tttgttttaa ctgttttagt 136200ttttgcttct ataatactac atatgttagg tatgtaatag aaagagggta ttagtatagg 136260ttactttgta gtaagtttat cattaatgta tttagttata gatatagata tatgttatag 136320aatatatagt aaagaaggta atagtaatag atttaagtta gcagtgtttt taactatact 136380tatattgatt atgtttatat atggagtagg tgttttatta acacaataga aagaggctta 136440ttatggaaga attagatata ctagatagag tgttacataa taaatcaggt ataggtgagt 136500ttacgtatac aaattgtata agaacaagtg atgataagta tatttatagg ttctttctgg 136560aagatactta ttttggttgt gctattatgg tatatgatga tatgagtgag tatgaagtag 136620tagtacaagg tacaggtaag gtgtatgttt ccttattgaa agatgtagtt agtaatatgt 136680ataagatact agtagatgag tatgataagt atttaaaaga tagtgcatat caaaaatata 136740tgtataatat atttgaagaa caagtagaac agtataacta aagtttttct ctagggaaaa 136800gcagtcaaag gtaaaaatag ggcttgaacc cgcattctat ggttgacatt taggtaaaat 136860tagataggtt ttccctagaa gaaaagttta aaaggtaaaa aaggagttgg ttactatgtc 136920aaaattagct aagttttgta ggaagtatgg agaagttact ggcataatgg agagtattac 136980agattatgag gtgtacttag gtaggggtta taaagtaagg tgtagagtag gtaatagcct 137040tatttatatt cttgtatata aagacaatca tatcattgct aggtttgagg aagcggataa 137100tatagtattt cctttgagtg atacgcttga ggtgggaaca attaaagact tagaggagct 137160agaaggtttg tatactaata tctatatatt actagggtat ttatatacag aatatgaaaa 137220taaagttatg tatgaatatg ggaggttaga ataatggata ttatggtaag tgaattattt 137280gagtatatat taggtcataa cactcacatt cttgggaatt ggcatactta ttacttagat 137340aaaggttact gtattaaagt taatgatgat aaacattata ataacatgaa gtttatcaaa 137400aatggtagag tagtaaaaga ggttattaac agtgacacct tactacctaa aggattcagt 137460agtatctata gtcttattga ttactatgag gaagctttag atgaaaagtg cagaaaagaa 137520aaagagcgtc tgaaagaaat tcgtacgttc ctaggtaagt aagtattata tataaccgct 137580tctatatgaa actttatacc tatagctatt ataactatag gtattttttt atatttctta 137640cataaatgtg ttgattttat gtgtgttaag gtttatactt aatatataat taaaggagtg 137700aatataatat ggatatgaac aaggaagtat tagaatgatt agatagttta ggtggtaagt 137760tagaacaagc aggtacacat agttatgaat ctttaattaa atacacaatt actcaaggta 137820ttatagattt atgttcaata agtatattat tatctataac agctatctta tgggtggctt 137880tgtataagtc agataaaaag tctaatgaag gtcatagtac cctattattt gagtttgttt 137940ataagaatga aaaagagctt tctgctgcag gatgcacagt aattatattt gctgttactc 138000tgtctattat ttctttttta gtgctattaa taggcttgcc tattgctatt caagagattt 138060ttaatccaga aggatatttg attaagagta cgatagataa tttaaaataa ttgtaaaaat 138120aaggaggaaa atataatgtt agaacaagct aaaggcataa ctacagatta tattatggaa 138180tttattgatg aacatgagca ttatttctat gaagacttac acaagttagc aggggagtta 138240gtgttgaaag atacacatga cacaaaccct attgttatta atgatggtga tggttactca 138300ggtactatta tatctaaatt taaatcaaag gtagagggtg ttccagatat cactgttagt 138360gatttttacg gttcatgttc tttctgtgat actttagcta atatctatga aggtagtgat 138420gaacttgaga taattagaga tttagctact atggtactac atacaattca atctatggaa 138480gagaaagtag aataatgtat aagggagtga tatagtgttt agtaagagaa aagaaattaa 138540agagtataag aaacaaggtt actctgttga ttatatgggt ggttttttag gattatttgg 138600tcttggcgat gttttatact atgtagaaac taataagaaa tacttaaagt caattagcgt 138660aggtaaagat gacaaccaat atgtatatga ctttaatggt tatgaatact tatcaagaca 138720taagttaaat atcaaagaag aagaactaat gtctaaagct attgctcagt taagtatcaa 138780aggtttaaag aattttaatg gagttaagca tatttgggat gtaggtttct tagagcaatc 138840ttttaatata catcgtaaag atattgatac ggttaaactt aaactaagtt ttgatgaaga 138900gggtaaccta tattatgaat tagaattagg ttggattaat atttataaag agtatacagg 138960tgtaaaagac tttcttaata cagtagataa ctatctcaac ttcttctata aagatatagt 139020cactagtggt cttgagttaa aacaagtact atataatact tttatgggag gagattatga 139080gtttgtagta tctccatata atgttgtagt atatagggaa gttgagttaa ttgatataaa 139140gaaattttac tctgatactt atggaattta ttcctatggt tatggcacta atgtacataa 139200acctttacaa acaattaagt attatctgga ataccctatg aatgaagtat aaccacttca 139260aatattatat aaaaggagtg cttaatatga gtaacggaaa agtagcgtta attggtagta 139320aggtattaga agattataat atttatacaa tcatgagtga gaaacatata tacttaagag 139380atagtgttga tgtgactttt aatgatggga aggtattacc tatatacatt gatagtgtat 139440taaaacaatt aagtaaagat gataaaaatc tatatttttc tgaagaagat atagatatta 139500gtaaacttac taatgacgag tattatacag ttactaaaaa ataaaaggag aatagataat 139560gagtagtaat aaaaaaatag cagaaagagt tattgagaaa tttttagatg agactaataa 139620aggtgtagat tttactaatc aagatgaatt taaccgcttc ttagataata cagaagactt 139680gtatgaagta tctggtactc aaagagataa gattattaag tgtttacaaa acattgtagt 139740tactgtattt atggataagg ggaaataaca atgaaaacaa taaaaagaaa aatagtacaa 139800gaaggtatga acaaagaaga aactatgatg gaagacgatt ctgttgtaat aaaaaaaatt 139860caaaaaataa caggcggagc tattcttcct ttagccaatg gcaaggaata tgtagtagtg 139920tttagtaaag tagaccctac taaattaatt gtatttaatg tggaacgtaa tcaaatctat 139980ttaagtggtt ctggtttcga tagtgaactg tcttatgtag acagtaaaag caaccctatt 140040accttagaaa cagttaggtt aatcactaat ttattataaa ggttattagg cttttaaaga 140100ttaagttatt ttatagaata aatactacta gaaaatgatt actgtttaat acagaatttt 140160aacgtaccta gcttaagggt attaaatata aaggagggta ttagaatgac taaagttgta 140220agtagaggat atagttttga agaacaagaa gtaagtatga actataatca aggacaatgg 140280gtgatttatg caagtagaaa accttatatt actgatatta tgaaaaagta ccctgataag 140340gtggaagtat tagaacaatt agaaaatgaa acaccagtat tggttaaagt tgtattggat 140400gaagatttaa ttacattgag aaagccaata agtaacgagc gtaaagaaca aatgaaaaag 140460attgctaaag aaagatttgg taaataatag agaggctgac tttaatgaac atcagtatgt 140520acactaacac ctgtagggac tagattaata ttacaagata tcttataggg ttatagtgtc 140580attgagaatg agtatgcttt attaaggtta gttaaagaag ataaacagta tttataatat 140640catattgaag aagtagaagc ggtattaaac cgcttctttt ttatattata tttatattct 140700gagtaattat gttgtattta atcttggcta ataattgtat atcaatttga gcatagtatg 140760cccgtttcaa catagttaat ctaataattt gtatatttat ctgttagtta tgtataaata 140820tttgttatta cttatttata tatttgtatt tcgtactaac cgtacgactt atctttttaa 140880aaagataaga acaaaacagc gtataccttg ttgttttacg ctacgctaca acaaggtaac 140940gcctgtaata agttattcgt attaaaatac taacaactaa ttacttgttg tttagattat 141000aacatatgtt tatgagaatt agatgagaat ttagttacaa cagcattata ataatattac 141060agttatgtta caagttgcta agtatgtttt gttactacaa tatattgaat atgaaagctt 141120tagacctttt ctgcagacaa gtaattatta caggtatgta tgataaaaga taagtatcag 141180ggattaaatt aaggttggat taatgaagcg gataagttag atactggtta aaataaaata 141240ctttacatta cctaaaactt atgatacact taggatagga taaaggagga atatcaatga 141300atattcaaga agcaaaggat aaattatacg atgaattact ttatacagta agtctttgtg 141360agggaacaga agaagattta ctagaactta ttgagaattt attttatatt tacaatgacg 141420agcctgcatt tttaagtaaa gacggtatgc aatatactat taaagatttt atggagagaa 141480gaaaaacatt agaacctatc ttaactgaat taggtatagg gtacgcaatg atagaatatc 141540acacacatac agaatacgag ttagttactt attcagtact taaagttata cagtatgatg 141600tagataacta tactgtaatt attgatacta atagtgataa gaatattaag ttatcagatt 141660taacattaga agctgttaag gatattttga atcaaattaa gtagctaggg ttgttttact 141720ctagcttttt catatgcttg tgttgcctat ttaactacct tatataagca agtaagtatt 141780ataggataaa tactacctaa aaagtattac cgttgaatat agacctataa gcttaatgct 141840ctcttactgt tataaacatc ataagtataa atctatgatt ttcctaagta gcaggcgctg 141900ttttcccttt atattaaccg cttcaaacaa cataaaaaaa gattaggtta atagcctaat 141960ctataactct tttatataat tcttgtaatt ctttttctaa cttttttatt gtttctatat 142020cattatttct tttaatagac tgacatataa atgcaatacc tttaatcaaa ttaaatggtt 142080agttttacac tgcattgtat acaattaaat cgatcgatta taataattaa tttaatctgt 142140actttctagt ttcttctata taatagtaag aaatcatttc ttttgaaaaa ctttcgtata 142200acctattgac attaaatcta ggatagtgta atgtaataag cgtagtaaac aaaccgaaag 142260gaattgataa gatatgaacg taaatcaaat tggagatata ctaatggaat tattagatat 142320agatggttac aaaagcaata actactatag aaatgactta aaatactcaa cacattatca 142380agttaaatat ttagcttaca ttgatggtag ttatgaaaca ttagaactat ttaaagaaac 142440gaaagtcttt agcgtatcac attcaaatag attaccaatt aacattaatg ttaaggtagt 142500gaacaaacac ttatttatag agctagataa tacgttatac ctagtgaatg agaatgcaga 142560aattattaaa gaaaaaaagt taaaataata gttgacacta tcattaagat agtgtaatat 142620aatagatgta gtaaacaaac agaaaaggaa ttgattaatt atgaaaacac taattactaa 142680cagtaaacca tataagaact acggctatga aatggaacaa ttcgagagag aaaacaacgt 142740aattatcaca cgagcatacc acgaaccaac aaagcaaggt tatagtcttg taatacacta 142800tacggaggtt aaataatatg aaatatttat attacattaa aggaacttat aacagaatta 142860aagcacaagg tacaatatca aatgactata gattatggtc aggtattgat gaatgtgatg 142920acttatacta ccatattaat aaagcttgtc atagtcttta taataatggt gtaaaggaaa 142980ttacagttac agacaaatgc gttaaactaa cacttaataa taataaaaca aaacttatta 143040aaaaagttta agaaaagtgt tgacacttac taaaatacat ggtaatatat aaatataaag 143100aaaacacaat aaacgaaaag gattgattaa ttatgaaaaa cacagtaaaa gaaatggcaa 143160acggaaacac taaacttgaa agattattag ttttagcaat tgaggaagcg gttatgacag 143220agcttgttga atatgatgca ttagataaat acaaccactt agaacaacag ttattaaaca 143280atgaagcatt aacacaagca gaacgtaaac catctaacat tgattatagc acttacgagg 143340gagctatatt agcacaagac aaagcagaac actttactaa cgttatctta aaccacatga 143400acaaagaaca atttgaacaa atgattatgg atattgaaac actagaattt aatgcagaac 143460aaatgctatt ctaaggagac attacacatg aacttatctg ataaagaact tatagatata 143520atggacaacg ttaatagctt cactgatatc agtgaagcta ttaacgaaac agtaagcaaa 143580caaacaatta aaggcagtga caaagacagc ggaacgatta aacagtacaa tagtttagat 143640gagttaagac aagactatga cataacaaca ctagcaccag acgtaataaa agaattactg 143700aataatcatt agtgtaaaac ttcccaaaat aattaactaa aactattgca attaactgta 143760tatttgatat aatgtaatta aggaaataca aataaaagaa aagggattga taaactatga 143820aattacttaa ccaaatggaa caaacagcag aacttgaagg aattgaattt gacttattac 143880taacagctat ctatgaaaca atagaggtag atgttgctga acacgattta ctatgcaaat 143940acattcatat tgtaaaccaa ttaaaagaga ataaagacat aacaccatta gaatatatac 144000cgtctaacct agactttaca gacgatacaa caataagact agttgataat aaagtgtttg 144060agttagcaga ttatatattg gaacatatgc gtgttgaaga gtttaataaa cacattaaag 144120actatgaaca aattaaagca gaagctatag aaatgatgta aaacaaattg aaagggaata 144180aactcccttt cttttttttt attatttatt aggattgtat acaataggtt aatataaata 144240tattatacgg gggcaggggt aaaatgccac taaagtgggt gggtctgaca gggctatgg 1442992145838DNABacteriophage ARSA0002 2ccttcatagt gtataaatag ttaggtgtct aactatttat ttttatatag ttttaactat 60tgtgaactat gcttatgtag tattaaacta tgctgaacct atagtaaact gttctaatgt 120atagttaaac taagctgaag tagtatttac tgtgtacaaa ggtatattta gtatcagata 180ttgtgtatat ggtatagtat aattatgaac attattatta ttattcatat atattgtttg 240tttttacagt actattgact caattttccc tagagtaaaa gtttaatata tttagcagtt 300tccgaacatt aaagaaattg taagcacttt gtatatatgt gttgacactg tgttgcttat 360agtgtatact taatgcataa aggtaaagga gatgatttat aatgaagatt aaaacagaag 420tttcgtttac agagctaatg aatatgtatt acaaaggcag tatagacaaa ggtcactact 480attctactaa tagtcagttt attgttagta taactgatgg tgaggtatcg ttctataatg 540tgtttttccc taatactacg gttggtacac ctaatagtac tactatacct aatgatacta 600gatttattgt agaagcggtt gtagatacca ctactgaatt atttagtcta gtaactactt 660ttaagcaagg tagtaacgta ttaaactcag tatggtatag agttagtatt gatgagttat 720ataatcatta taaaagtaaa aataaagagt tattatcagt tagtactgtt gtagatgatg 780agttagttac tatatggaaa gatggtaaga tattgtgatt tggtatatag tactatttag 840tatacttata tgtatagtta gtgttttaat tctatacgta tcttacaaag aaggttttac 900tattaggata ctaggttact gatactacta tttatactaa cagaaattac aagatttagt 960atcaatacaa gtaatgctat tctatgtaca gtacttgtat tgttatgtgt agtactagta 1020tatagaggag ttaaataacc gcttctatat gaaactttat acctatatct attataacta 1080taggtatttt tttatatttc ttacataaat gtgttgattt tatgtgtgtt aaggtttata 1140cttaatatat aattaaagga gtgaagttaa tatggatatg aataaagaag tattagaacg 1200tttagatagt ttaggtggta agttagagca agcaggtaca catggttatg aatccttaat 1260taaatacaca gttactcaag gtattataga tttatgttca ataagtatat tattatctat 1320aacagctatc ttataggtgg ctttgtataa gtcagataaa aagtctaatg aaggtcatag 1380taccttatta tttgagtttg tttgtaagaa tgaaaaagag atttcttctg caggatgcac 1440agtaattata tttgctgtta ctctgtctat tatttctttt ttagtgctat taataggctt 1500gcctattgct attcaagaaa tttttaatcc agaaggatat ttgattaaga gcactataga 1560tagtttaaag tagagtaatg tataaaggag tggtatagtg tctaaaaaaa gaaaagaaat 1620taaagagtat aagaaacagg gttactctgt tgagtatata ggaagtattt taggtttatt 1680tggtattggc gatgttttat actatgtaga aactaataag aaatacttaa agtcaattag 1740cgtaggtaaa gatgacaacc aatatgtata tgactttaat ggttatgaat atctatcaaa 1800atataagtta aatatcaaag aagaagaact aatgtctaaa gctattgctc agttaagtat 1860caaaggctta aagaacttta acggagtgaa gcatgcttgg gatgtaggtt ttttagagca 1920agcttttaat gtacatcgta aagctattga tatggttaag cttaaactaa gctttgatga 1980tgagggtaac ctatattatg aattagaatt aggttggatt aatatttata aagagtatac 2040aggtgtaaaa gactttctta atacagtaga taactatctc aacttcttct ataaagatat 2100agtcactagt ggtcttgagt taaaacaagt actatataat acttttatgg gaggagatta 2160tgagtttgta gtatctccat ataaggttga agtatatagg gaagttgagt taattgatat 2220aaagaaattt tactctgata cttatggaat ttattcctat ggttatggca ctaatgtaca 2280taaaccttta caaacaatta agtattatct ggaataccct atgaatgaag tataaccact 2340tcaaatatta tataaaagga gtgcttaata tgagtaacgg aaaagtagcg ttaattggga 2400gtaaggtatt ggaagactat aatatttata caattatgag tgagaaacat atatacttaa 2460gagatagtgt tgatgtggct tttaatgatg ggaaggtatt acctatatac attgatagtg 2520tattaaaaca attaagtaaa gatgataaaa atttatattt ttctgaacaa gatatagata 2580ttagtaaact tactaatgac gagtattata cagttactaa aaaataaaag gagaatagat 2640aatgagtagt aataaaaaaa aatagcagaa agagttattg agaaattttt agatgagact 2700aataaaggtg tagattttac taatcaagat gaatttaacc gcttcttaga taatacagaa 2760gacttgtatg aagtatctgg tactcaaaga gataagatta ttaagtgttt acaaaacatt 2820gtagttactg tatttatgga taaggagaaa taacaatgaa aacaataaaa agaaaaatag 2880tacaagaagg tatgaacaaa gaagaaacta tgatggaaga cgattctgtt gtaatcaaaa 2940aaattcaaaa aataacaggc ggagctattc ttcctttagc caatggcaag gaatatgtag 3000tagtgtttag taaagtagac cctactaaat taattgtatt taatgtggaa agtaatcaaa 3060tctatttaag tggctctggt ttcgatagtg aactgtctta tgtagacagt aaaagcaacc 3120ctattacctt agaaacagtt aggttaatca ctaatttatt ataacggtta ttaggctctt 3180aaagattaag ttattttata ggataaatac tactagaaaa tgattatcgt ttaatataga 3240aatataacgt ccctagttta agggtcttaa atataaagga gggtattaga atgactaagg 3300ttgtaagtag agggtatagt tttgaagaac aagaagtaag tatgaactat aatcaaggac 3360aatgggtgat ttatgcaagt agaaaacctt atattactga tattatgaaa aagtaccctg 3420ataaggtgga agtattagaa caattagaaa atgaaacacc agtattggtt aaagttgtat 3480tggatgaaga tttaattaca ttaagaaaac cggtaagtaa tgagcgcaaa gagcaaatga 3540aaaagattgc taaagaaaga tttggtaaat aatagagagg ctgactttaa tgaacatcag 3600tatgtacact aacacctgta gggactagat taatattaca agatatctta tagggttata 3660gtgtcattga gaatgagtat gctttattaa ggttagttaa agaagataaa cagtatttat 3720aatatcatat tgaagaagta gaagcggttt aataccactt cttttttata ttatatttat 3780attctgagta attatgttgt gtttaatgtt ggctaataat tgtataccaa tttgagcata 3840gtatgtccgt ttcaacatag ttaatctatt aatttgtata tttatctgtt agttatgtat 3900aaatatttgt tattacttat ttatatattt gtatttcgta ctaaccgtac gacttatctt 3960tttaaaaaga taagaacaaa acagcgtata ccttgttgtt ttacgctacg ctacaacaag 4020gtaacgcctg taataagtta ttcgtattaa aatactaaca actaattact tgttgtttag 4080attataacat atgtttatga gaattagatg ataatttagt tacaacagca ttataataat 4140attacagtta tgttacaagt tgctaagtat gttttgttac tacaatatat tgaatatgaa 4200agctttagac cttttctgca gacaagtaat tattacagtt atgtatgata aaaggtaagt 4260atcagggatt aaattaaggt tggattaatg aagcggataa gttagatact gattaaaata 4320aaatacttta cattacctaa aacttatgat acacttagga taggataaag gaggaatatc 4380aatgaatatt caagaagcaa aggataaatt atacgatgaa ttactttata cagtaagtct 4440ttgtgaggga acagaagaag atttactaga acttattgag aatttatttt atatttacaa 4500tgacgagcct gcatttttaa gtaaagacgg tatgcaatat actattaaag agtttatgga 4560gagaagaaaa acattagaac ctatcttaac tgaattaggt atagggtacg caatgataga 4620atatcacaca catacagaat acgagttagt tacttattca gtacttaaag ttatacagta 4680tgatgtagat aactatactg taattattga tactaatagt gataagaata ttaagttatc 4740agatttaaca ttagaagctg ttaaggatat tttgaatcaa attaagtagc tagggttgtt 4800ttaccctagc tttttcatat gcttgtattg cctatttaac taccttatat aagcaagtaa 4860gtattatagg ataaatacta cctaaaaagt attaccgttg aatatagacc tataagatta 4920agtctctctt actgttataa acatcataag tgtaaatcta tgattttcct aagtatcagg 4980cgctgttttc cctttatatt aaccgcttca aacaacataa aaaaagatta ggctattaac 5040ctaatctata attcttttat ataattcttt tatataattc ttttatataa ttcttgtaat 5100tctctttcta acttttttat tgtttctata tcattatttc ttttaataga ctgacatata 5160aatgcaatac ctttaatcaa attaaatggt tatttttaca ctgcattgta tacaattaaa 5220tcgatcgatt ataataatta atttaatctg tactttctag tttcttctat ataatagtaa 5280gaaatcattt ctttaaaaaa ctttcgtata acctattgac aatcaatata agatactgta 5340atataataag cgtagtaaac aaaccgaaag gaattgatag gatatgaacg taaatcaaat 5400tggagatata ctaatagaac ttttagacat ggacggttac aaaagcaata actactatag 5460aaatgattta aaatattcaa cacattatca agttaaatat ttagcttaca ttgatgatag 5520ctatgaaaca ctagaactat ttaaagaaac gaaagtcttt agcgtatcac attcaaatag 5580attaccaatt aacattaatg ttaaggtagt gaacaaacac ttatttatag agctagataa 5640tacgttatac ctagtgaatg agaatgcaga aattattaaa gaaaaaaagt taaaataata 5700gttgacacta gaactaagat agtgtaatat aatagatgta gtaaacaaac agaaaaggaa 5760ttgattaatt atgaaaacac taattactaa cagtaaacca tataagaact acggctatga 5820aatggaacaa ttcgagagag aaaacaacgt aattatcaca cgagcatacc acgaaccaac 5880aaaacaaggc tatgaccttg tagtacacta cacggaggtt aaataatatg aaatatctag 5940aatacattga aggaacttat aacagaatta aagcacaagg ttctataata aatgactata 6000gactatggtc agatatggaa gaatgtgatg atttatacta tcatattaat aaagcttgtc 6060atgctcttta caatagcaat gtaaaagaaa ttacaacaac agacaaatgc gtgaaactaa 6120cacttgaaaa tggaaaaaca aaacttgtta aaaaaggtta aaataatgtt tgacattaca 6180tttaagatac tgtaatataa tagatgtaat acaaaaacaa acaaaaggga gctaataaca

6240tgagagatat aagaatagtt ttaagagaaa ttgacgaggt acagcaagcc ttaatatatg 6300gtaggaatag cagagagtta gcacgttttt tacgtagaca actggtaaaa ctagagaaag 6360aaagacaaga tataaattgg tcatagccaa aagcctatta cataggctta aaaaataaaa 6420ataagggatt gatacacaat gattaaagtt aaatataaag gcaagaaata ccgctcaaca 6480caaaatacag atgctattgt aactattata ggtggtacag cagtaatcac attgatagac 6540tggtttatta gattacaaga gaatattaat atatttatta gataagggct aaccaccctt 6600atttttttat gtctatataa ccgcttcaca ttagtgtaaa acttccctta tttctttgat 6660ataatacttt acaaatacga gcttatactg taatatatta attgtagtaa ggaacacaac 6720aaacaaaaaa agaagaggga ttgattactt atgaaaaact ataaaacttt agaagaatta 6780aaccaagatt atacagttat tagaacacaa aacgaagctt caagcaaacg taataactta 6840gatgttactg atatttatgt taatgattgg ggtttgttac aatatggtat ttactttaac 6900aaattcgata acgtgtacaa tgtagtttca atgacatcag gaaacaagaa atataatatt 6960actgcttatg aacttgatag ctttattatg gatgagttaa acaaacagtt agagttattt 7020attaatgcag gaagactata aaggaacaca acaaagaaca gcaaacaaat aaaaaaaact 7080taaaaaagtt ttaaaaaagt gttgacacta acatcaacat agtgtaatat aatagatgta 7140gtaaacaaaa acaaacagaa aaggattgat taattatgaa aaacacagta aaagaaatgg 7200caaacggaaa cactaaactt gaaagattat tagttttagc aattgaggaa gcggttatga 7260cagagcttgt tgaatatgat gcattagata aatacaacca cttagaacaa cagttattaa 7320acaatgaaac attaacacaa gcagaacgta aaccagctaa cattgattat agcacttacg 7380agggagctat attagcacaa gacaaagcag aacactttac taacgttatc ttaaaccaca 7440tgaacaaaga acaatttgaa caaatgatta tggatattga aacactagaa tttaatgcag 7500aacaaatgct attctaagga gacattacac atgaacttat ctgagaaaga acttatagat 7560ataatagaca acgttaatag cttcactggt attgatgaag ctattaacga aatggaaaac 7620aaacaaacaa ctaaaggcag tgacaaagac agcggaacga ttaaacagta caatagttta 7680gatgagttaa gacaagacta tgacataaca acattagcac cagatgtaat aaaagaatta 7740ctgaataatc attagtgtaa aacttcccaa aataattaac taaaactatt gcaattaact 7800gtagatttga tataatgtaa ttaaggaaaa acaaataaaa gaaaaaggat tgataaacta 7860tgaaattact taaccaaatg aaacaaacag cagaacttga aggaattgaa tttgacttat 7920tattaacagc tatctatgaa acaatagaga tagaagctgt tgaacaggat ttactatgta 7980aatacattca tattgtaaac caattaaaag agaataaaga cataacacca ttagaatata 8040taccttctaa cctagacttt acagacaata caacaataag actagttgat aataaagtgt 8100ttgagttagc agattatata gtggaacata tgagtgttga agagtttaat aaacacatta 8160aagactatga acaaattaaa gcagaagata tagaaatgat gtaaaacaaa ttgaaaggga 8220gttaattccc tttctttttt ttattattaa ttaggattgt atacaatagg ttaatataaa 8280tatattatac gggggcaggg gtaaaatgcc actaatacca cacattttat atgtatatac 8340ccgtctaccc aggtactatg taagtactat aactatacag tatcaataca aaagtcaact 8400aaataaataa acaaaaactt atttatttta ttataagtca acaatttttt tttatacctc 8460ttgttagctt tacatgtatt atattatagg tagataataa aaaaatgagg tattaaaaat 8520atggataaaa atattataaa agttaataag agtaattatg aggtatggat agacttatct 8580aaccttcctt taaagaaaac taaatatata aaatataact ataatattat agaaaaaatg 8640aaaaacattg aggttccttt tagttacaaa ggtttagaag acacaatgta cttaacttta 8700aagtctagaa ctcctgaggt aacgtatgac tatgagtata aaggtgaaaa aggaacaata 8760actatgagtt ctcttaatag agtagcatta gatagagtaa catacaatga acgtaaaaga 8820aaaggcttaa ttaaaagatt taatggtaaa cgttctgtag acttaaataa tctaagaaaa 8880cttgataaag aaaagtatta tggtagagta tcttatgata tagattttaa aaatagtata 8940ggtctttctt ttacctattg ttttgaagat aagaaaggaa aacttaaaat tatagatgct 9000ttttctaaaa aaaataacaa aggtaaagac gttgaatatg ttagattaga aaatagtaat 9060ggagatactt tcttatataa tgctcttaat attatcatag gaaatttaca acgggttgct 9120gacccttatg tttatcctta tgatgtagga aatactttag gtaaatttaa tgtaaaagaa 9180aatataacag aagaaaagat agctaaggat ggtaaagtag agacaacacg ttttagtata 9240gtagagtgta atgaatgtgg tatgataaag aaaataaaaa caagccacat aaatagttat 9300tctagggatt attgtgcgga ctgttcttct atgaataaat ccattaacaa ggttaataaa 9360catagaagcc gaggggagtc tatggtggag caggtattaa aacatcaaaa tattacttat 9420attgcggaaa aatcatttga ctggtctaat cgtaagcgtt atgactttta cttacctgag 9480tataacaccg ttatagaggt acatggtgtt caacattacc tagaacaaaa aaagggtcaa 9540aggtttcatt taacattaga agaaaacaag aaaaatgata aatggaagag aagtcaagca 9600ctttcccatg gattaaagta tatagaaata gatgtaagag aacatagctt tgactatatt 9660aaaaaaagta ttataagtag tgacttacct acagaatgcg tagactggaa agaagtatat 9720aggtatatgg aaaatggatt tattcaagaa attatagatt tatacagtaa aggttatagt 9780attaaaaaaa ttagtgaagc attaaatact tctacttcag taattacgga taggttaaaa 9840aaggcatcta gtcttggtct tgtagactat acaccttttg accataatat taagcaagta 9900gaagaaaaac tatcaagaat gaaaaaagaa agagacaagt atttaaaaaa tataaggaac 9960ctttagttta gattccttac cttaacactt atatacctct attatgatat gaaaaaaagc 10020acctactaaa taccataggt gcttactata catactcatt aattagacat caaggtcata 10080tctatattca aacaattctc tatctacttg ttcgaaacct ttctttttat cttttataat 10140atagttaccg cgtacaactt tctcaatacc tgaaggtgtt ttaataaaca ggctattgtc 10200tccttgttta tctactgctc taaatgtttg accttctgtc cactgattaa taacatgctt 10260attatatcct gtatattgaa tatactctac tacgtcttcc atatcgatta tgacttttag 10320catagactct cttactttag cataatcatc tgtaggggta tctaagtcta atggttttaa 10380ttttgctata ttgcttatat tacattctct tacaggtgtt tttgaatatt ctaccattaa 10440atctagtaat tcttcacttg cacctagact cctaaaagaa tattgttcgt tgagaaacac 10500ccaagcaata ggttgttggt tttctttttt aataagtatt ttttcttttc ttttggtagt 10560atttttattt gctatggtaa caatataacc taactgtttt acattttcaa taaattcatt 10620ggtatacata ggtggtactt cctttgttta attattatcc actatgtcta tttcatggat 10680tgtaatcatg tcatctctat actcatctat atgcttaagg taactgacgc catcatgttt 10740tctagacatt ccttgtaatt ctctatatcc ttcggcttta atatctttaa caagctgttc 10800tttgttagtg tatactttat cttctctata tgagtagcta tcctcataag gctcacaata 10860gtcatgttct acttgatata gtttcatatt atttttactc ctttttaatt ttatcttcta 10920attctggtaa tacatttttt gaaatatatt tatttaagtc atttattgtt ttaactctat 10980aagtacgcat gtttctgtta ctaatatata aattatataa atactctacc ttactttcaa 11040tataatagaa aggatagctt atacaactca ttaatagaga tatactatac agtatatttt 11100caggtaattc tctagtaaat tttttaattt tatttaccct tttttctctt cttaattttt 11160tatatagctt tcttaggttg tgctcatgtt ttttaattac aagtagttga ttttggttaa 11220gtaagctatc gtcgtttttg tttatatagt ttaatattcc tttatataaa gttagtaatt 11280ctctatcatc catattaata ttatctcctt atgttctaca tttaaccaga ctaaagtata 11340aatgacttga ggctctatat ctcatttatt ctatgtcctt cttttactga ttggttccat 11400gattttagtt tttcaaagaa cttggagtct actttacctt ctaatttttg gttagtataa 11460tcatcataga aactaaatgt tccgccttta aaaaagcaat aatacgtgtc tgtcgtatag 11520ttaatattaa tgtactctat atagtctttt gttacttctg gtttgtcata acgtaagact 11580ggtatttctt gacgtaacaa ttttattcct tctttactta aacctgtata tctttttagc 11640ttgaaaccga acctcaacca aaagtctatt tcattgaggt taaaaggttc atttactttt 11700ttacctaaaa tactatgcat aaatagcata taaacaagtt ctatatactc tatacatgtt 11760gttaaaaaat gttgtttgtc ttcaaagtga tggtaagcca acaaatacaa aaacgtaaaa 11820gggaaaagaa caatggacat taaaaaatat aaaaatgatt ttaatcttgt gttcattact 11880cagacacctt ctctacatca tatagtattg ggtatagatt gaagatatga actctatatc 11940caatagtttt aacttttact ttatctccta cttttaatct agcttgtatg tctgcgctat 12000caaactttct tttgaagaat aagtctgagt tttcaatgac ttgtttgttg tctaatacaa 12060tatagaactt gtcttcttta tcttgtcttt tgttatattt atctgtaatt gttccttggt 12120gcgtttcttt gtgttgatag ctagccactg tatagatagg taaagtgata acaagtagca 12180atacggttat accgaataat gacagtattc caaaaataaa gatatcgaac caattcatat 12240ttttaagttt tttaatcatt gttacagcaa tctcccatct tcccaaatta gtcttaactt 12300actttgatgc ataatataga agcgctcaga tttactagat ttaacttcat ttattgacat 12360attatgatga gtgagtatat tttcgttatc tagatactcg tatagcttag taaataccat 12420gtcttcggta tagtcaataa ctgatagctc tttgattaaa acatggtctt ccttataatc 12480atttatattt ttgtaatacc catatcccct tactgcatcc catacctttc gtacccttgg 12540tctaaaagtg agtttactac ttgttcttta tccctataga cttttgtttc tgtatatgtt 12600tcttgatatt cacgaggttt acaattatca tgttctagtt gatacagttt catagctacc 12660ccatcctttc caataagtat ggattttcat atatatttcc tttaacttgt aactctaaag 12720tatctgtgta tggttttatg gagaaatcac taagtaaagt aagtttacac cctgcatacc 12780tcactatata gaaaaatccc ttacccttct taactaaacc taggtcacta taattacctt 12840tggtatttag tatttctata atatctcctt catatatatc attaccgttt acatctttaa 12900cttctgtgct ttgcataatt tcaaggtttt ctcctaaata accttcacaa gcaaatagat 12960gtgaatatac tgtgtaatct gcaaaatcaa atctatcaat attaaacatt ctttgtgatt 13020cttcatccca tgctctaaat ttcaacatca tattacctcc actttttcga tttctatgct 13080tacagttttg aataggggct ttttacgagt cagttttaat accgtattcg tgtcttcttc 13140ctcattcgta ctttgcacaa aataatgctt ttttaattta taattacatt tagacgctaa 13200gaacttgata caaagactta ctttataggt ttgcatcata ctatcaactc cccatctttc 13260cagattaacg tcatggttag gtcatcgttt aagatgtaga atgctttggt agggaaagac 13320gtgttctcta aacgttcttt gatactggta tttgtgtgca gcgctgacat ataggctctt 13380tctcgaaact catatacttc aaacaaccta tcaaacttag tatcttctgt gatttcctct 13440tcaactttga cttcgaaaag agtatcgata gaaataaaac ctcctagagt aaaacattta 13500tttgtatctt tttgaaaaca taccgcttca taactttcac ctgttgtaca atattttttg 13560ccttgtgata gctctggatt ttctctagcc catttaatta actcgtctaa tggcatttct 13620tttttagttt ttattttcat ttttatatct cctaattatt taatttttct atcattttca 13680taatcttttt tgattctcta atgtcagcat tttcacagtt ttttaatata aagttaattt 13740tgttttttac atcattaacg atactgtcta cttctttttt tgttggctcg gtagggaaaa 13800gcaaccctac aactatctga atttgatttt tatttagtga gtaaacacta atgttacatt 13860tctcattaga gtcaatatgt ggtttacttg aattaaatac ctcatctaca attgtattta 13920attcttggat aggtttaaaa taatgttgtt ttctttgtat cattacctgt gacattagtt 13980tatatagttt ctgttcttta tcaagcattt cttttgtaag tcttttaact tcccctacct 14040ttatagtatt acctcgtgca tcataattat ttttaatata ctcagcttct tctatgttag 14100tagtatatcc tattacttct gaggtgggtt cctcatcgta gtaacagtcc tcttctacat 14160atatagcata tatcttattc atatctatca aacctttctt taagttaaat taactataac 14220atataagcat tagggtgtca actactaata tacacttttt acagtaaaca aaaaaaagaa 14280cctttttaca ggttctttac taggttatta attttttaaa tcttgatttc cttttattag 14340cttcttatca tcaataggat gaccattgta taaatatttt acttccatat atacatgatt 14400atccgtagcc gtaagggcat ctaggatatc cggatttgtg ttaattgcat ttgtatcagg 14460aaacgaaaat tttcttttat cagactggat tgtatctaca tgaaattttt cttgttttgg 14520taaagagtaa ttaaggtctt ctaaattttg taggaattta gtaagagaaa agggtttgaa 14580ctttccttgt aaattattat ctatataatc atttaatagt cttgtcattt cctctttatt 14640taaagtcatt gtttcataat cgttaacatc ataaaaaaca acaatattag gttgctcaat 14700acttgtatct ccatctttgt acttagcaat gtaatagcct atttcacctt tatgagctaa 14760ataatcttct ttcatgatat taaatacttc tctagcaata ggttttgtat atagttcttc 14820ccattcattt gtttctgtgt tgtaaaaatg tggtaataag tttgccatta tagtttatcc 14880tttcttattc cgatttaagc catattttgt tagtgtcttt aggtggttca ttgctgattg 14940tgtacccgtc ggtacccata tctaatgtgt ttacaatgac aggctgagct acagcttctt 15000tttcactctc taatgttttg aaactaggca catctgtttt attagattct tgtccatcga 15060ctaaccaaga gactttaaag tcacctttat tataagtagt attaggtttt aaatctgtta 15120atgttacttt tactgtgcta cctgtaactt catcagaagt taaaataagc tgttcctctt 15180tgttgtagac ctttaatttt ttagtcataa tgttatccct ttctgttgtg taatacacta 15240ataatatagc atataaaaaa acaggtaagg gctttcaaaa cctttacctg cttattcttt 15300actgataatc ataccaatca agaaaatcat ctgaacagct taactctata gttatatcat 15360ttataagttc agtagcttca tctttactta atgactctat atcaaaagta aactcatcat 15420ataaacaatc tatatgctta taaataaaat ctttttgttt ttccgtagct ttgtttaatt 15480cattgctttt tttacttata aattgactaa agttatcact catttaaatc ttcctcttta 15540ataaaggtac cattaattgt tttaccttta cgtcctttaa tttcaccata agcaaactct 15600aaacactctt gtaatgacat gtcgtgttgc tgagctaaaa taattaaagt aactacagtg 15660tccccaatac catctttaag agcttctagg ttaccacgtg ataatgccga tgctacttca 15720cctgcttctt cgtagaattt aagagcttgt ctatcagggt tgttattgtt caatccttta 15780tctttactcc attcctctac ttggctaact aaaccttcta gcgtgcggtc ttctgtttca 15840ccttcattaa agttaggttt ttcatcattt ggtacatgtt cttcttgttc tctatcctct 15900attgtaataa ataaagtgtc tatttctttt tcgtacttat ttctctgcat ataattatac 15960tgaccatact caggataagg tacatataca gtatcgtctg taccatcctc ataattcaaa 16020caaacacaaa caatatcttt gccacttaat ctatcatata atgtcatgtt gtagggctca 16080tctaagaaac catgaaactc ttcaaagtat tcatccttca taccacttac ctcaatagaa 16140actttttttg ctgatttact tgtatctact tcactatttc catatatcat agttttttct 16200tcactaatac cttctagtat caactctaca ttttctggtt ctaacattgc gctatctaag 16260ttttcaaaaa caatttcaat atttttaatt tttttagtca ttaataatca ttcctttttt 16320ttagtatata gtaaatataa cacataagta aatagaagtc aataaaaaaa aacacctact 16380ttaaaaataa gtaggtgtaa gatattttga aggtagtttg taggaaaaaa tcctgagaga 16440ggactcgaac ctcaacgact aggtagctac aactagccaa taccattact caggattgct 16500agtaacgata aatagagtta taacgttacc gtagaccttt tctacgcttg ttagataggt 16560agaatataat gattttacag tactcatata gttaggctgt tactctcatt ataaggttaa 16620aaaatgctaa ctatgtttcg cattgttaag aggcgttagt taactactat aataatatag 16680catatatttt attgtttgtc aagttcttta ttccatttac ttttttcttt tagtaatcct 16740tttttaatta attcttcact aatactttta tactctttat tttctttata gaacacttta 16800gctaaatatc taccaaaaga atcatctttg tatgtttgaa ttaaaacatc ttttccttct 16860aacatagttg ttgtaaattc cttagcttct tggtaattat tttgtttctt ttctggtgtg 16920tcgacaccta gtaatcttat tctttgctca gaatatgttc tcattccgtg gtcaatagtt 16980acatgtatag tatctccatc cactactttg tccacgtgtg ctttaaataa atataaattg 17040tcttctatca ttattaaatc ccctttttac taatttaaaa atatccaatc agtattgctt 17100gatgtacctt tagctatata tacagatgag cctactacag caatttgacc tttatataaa 17160ggtgtgttgt taatactttc tgttactcct atttgactta caacttcaaa attagctttt 17220gtagctataa attcccaaaa tatagaacca tctgatataa caccgttatt atgagtaggt 17280tgtgttccac cacttgtacc tgaagctact gctttatata cataattccc attataaaca 17340atttgacctt gtgtataatc cgtgttagat gtccacttca tattagtagc aactccatcg 17400ctaatacatc tccatttctc aggactacct gatgttaagg ttctactagt attaacaaca 17460atatctccca atctccaact tcctgtcgtt ggtattgcag taccgttcag tactttaggt 17520aaattataag ctatgttatc cttacttata acattaaatg cattactaga aatacttaag 17580tttttattca tattgttatt taatacgaat aaattactac aagaaccttg aacacttaat 17640gaatcattac ctttatctgt ttttatatca ttattagtaa ttgtactatc cataacaaaa 17700tttaagaaca tagctttatc caaagaagta tttgtacttc ttaatgtatt atttttaaag 17760ttaatttctg acacaggttt actagttgtt cctgaggcat aaataatact tgtttttaaa 17820cttgttgtat cttgttttaa tacattattt tgtatatcta tgttattaac tcctggataa 17880aggtacaact cgtaaccctc attacctgat acattattgt tactaataat tcctttacta 17940cctcctgtaa tagcaatacc attagatggt ttattactta actctccttt attactattg 18000ccataaatta cgttattagt aattgtatag ttagtacctg atatactcag tcctgagtac 18060ttattgtttg tatgtatgtt attacttata ataacatttt ctgttcctga ttcaaaaccg 18120cttgaaccat ttcctgtaga tatattatta acataatatc catttttagt accgcccata 18180aagttaaaac cattctctaa acattgtgta gctgagcaac tgtctatagt aatgttatct 18240gagtaaccat aaacaccatc taccgcttgc atagtgttta ctgcatttac aacgttaccc 18300ataatattat aaccatgtac attatatgct ttacagtttc tacttccttt aaatgctatt 18360ccaatagaac gaggtgacgc atatctaaat tcacctttac catcccattc ccctttaaat 18420gttaatcctt ctacaagaat gttatcacag ttgataaatg agaatcctgt aaacatatct 18480ctaccactag aagaaacatc atctatagag tctagatagt ttttagtgat tcctgacata 18540ataaatgtag gattaccttc acctttaatg tatatattac ttcctgttac ttttacacgt 18600gatgggtttt gtacagtagg tgttttagtt ttgaataaat agtcctctgt tcctttaggt 18660actataagag ttccaccctt agtacttatt aaataatcta aagctctttg gaatctaggg 18720taatcattat cttcatcatt aattcttggg taatcttcta tattaactat tactttactc 18780ttagaattag tatctttacc tagttctttc caatcattac cttttagtac ccaaccatat 18840gcttgtgttg taccattgtt gtataccttt tcatcatatt taaaatcttc aacactagaa 18900ggtttaacat gagaataaaa aacatcagtt ttattcttgc tactatcgtt tgaagactta 18960ataatattag atggattagt tgaagctaca agtaaacctt gcatagttcc agatattaaa 19020ataacgatag acttaacatc ttcactatta acagtaaaag tatctttttg ggtgttattg 19080aaagtgaacg ctttatattt atcgttataa taaccatcca gtaatattgt atcataatta 19140ttagatattt tgtctaatat attaccgtct ttatcaaaac atttaataaa tataccacta 19200gaattaccta taaatgataa cttgttaata attaactcgt caccaacact aacattatta 19260acatataaag ccatagggta cgagcctgta aaggtaagta atcctttatt atctactaaa 19320ctaggtgtag tactgtagtc ataagatact tcatctgtta gagaagttga ctgtaatggt 19380tttctaaata catttttgac tgtatgatag ttacctccta atcttctata gtctttgcta 19440aaatcattat ttttatacaa taacgttgtt ttgtattcgt ctactatttt agcaatacta 19500cttctaggta ttttagcagt attaatattt gtaaacgtta gtttatgtcc attacctaaa 19560acaaattcag gaataaactt aatatcttta ctatgtgtta cataagattt tgtcatatct 19620tgagtttcta aatcaacaac cgcaaaagta gctttgttat taaattcaaa tctgtaattc 19680ttaaatataa atcctactgc tttcttaaga taaaccataa cataattttc agatgttgtg 19740gaagcagttt caaatttaag tgaatcgaat acattgctat ttcctccata ggtattacca 19800tttgttagag tttgtttgat gttatagtat gtgttagggt gtttattaaa ctcagtgcca 19860ctatatgaaa aagctgattt atagaagtaa ttactattca tccaagattg ctcaccatta 19920gaacctatac catctgtatt taattctata tgtgtttcat tattaataaa gaaattaata 19980atagtattat taaaccaatg acctctacca ccagtagctt tatgtttatt acctactgta 20040aaaccaataa tttcattaat attagtatta acatttctac agttaactaa ttctagtcct 20100atatagtttt gactcttaaa accatgatag cctccaccat aagttggata agaactatca 20160tcataaatac ctttaattgt aacattagaa tatgataaac tatctagttt aatagctggt 20220ttatccttac taccattata aacaatctta gcatcagata caatattaat attcttatct 20280attatcaaag tatcatctat tttaataggt gattcactag aaggaatgtg tagggtatta 20340ccttcacttg tatctttaat agcacgtctt aacctttgaa catccgaagt atcatctttt 20400tgctttatat actcgttaga gtatacataa ggacttttac ctgttttaag ccaatctgta 20460gctgaacctg taaaaccgtt atttacagct acttcataag cacttaaacc ttgcttacct 20520tgttcccctt tctccccttt ttctccttta atagacttaa cccattcttc ttcagaaccg 20580acaaaaccat tatctaccgc tacatcataa gcagatttag catttacaag tatatggtct 20640ttaaaatata atgttatttc tttgaatgat gattctaggg ttgtaaaacc aggaactact 20700actttatcgg tttcatattt ttcagcttcc catgatacat agaactcacc ttgagggtaa 20760tgggtatgag gagctaagtt aggtatgatt acagacccta cttcttcatg taactctaca 20820ttgtaaccta ttgccaatat attaccgtat ttatcatatg cttttaaatg aggcattgaa 20880aatctccttt attattagtc aatgttaata tatcataaaa cacaaaaaag ggcaaattgc 20940cctttagtta cagatatcat ttagatgaat atggtcttgt actgaatagt ctacaatgac 21000atgtgtatgc tttttctttt ttgttaacac tttatatgtg ataaagaatg atataatagt 21060taaacatata tttaattttt tcataaaatt tctcctttaa agaaggtatt taccgtctca 21120gtagttaatt ctttgctttt aaagatacaa gattctgtat ttttattcaa tatttctaac 21180atattttgca tactacttgc tttttgtaaa tccgttaagt ctataacaac tgttatttct 21240gcgttatcta ttagaatatt acctatgtaa taatttttaa ctccgttctc cgtagcatga

21300gaggtaacat tatgatttaa aacaactata ccttttgatg gtaagtaatc tgaaaagtat 21360aggtaacaaa agtatttatg tatctttttt ttatcctctt ccattactat taccatattc 21420tatgaagttt aacaaccttt cggtataggt tttaattttc tctacttctt ttctttcatc 21480gtcttttctt cctaatcttg ttgtatattt aacaatatta aatagcatgc agtctataaa 21540gccaataatg tagaaatatt cttctaaaaa tgatataaca tcttttttac ctttataatg 21600gttcggtgta ttagtggtag agttgacatt atagtataac tccagttgtt ctacattttt 21660cataagcttt ttagcataat ataatgtgtc atctaaagaa tgtgtcacat ctaaagatgc 21720ttcaacaatg tttatcttta attcttttaa ttctgttgcc tctttgttac ttccaatttg 21780tgaatcaata aattctctag tatccatatt ggtgtccttt cgtatctaaa ataaaaaccc 21840tatctagaat atagataggg aaaaggaaag atattatgga agtgtactat aaagtacaca 21900tataatataa cagttccttt gccttttaat ctatatcatt tattttaact tcttgtactt 21960taacataatc tgataaacta ttaacgacga tattatcttc tactaattcg tttctattat 22020ttgtaacatc atatgagtct ctataaggtg tttgtactaa tgctctaact gtaatgtcta 22080tatctacata ttctttacta tacctttcca ttactcaacg tagtttcctt tagcaagctg 22140atactttttg tgtaattctt catataattt ctccatatct ttatattttc gtacatcttc 22200ttcaaaatga cttaaatact ctattaatgt cttaacttct ttaggttcta aagttataac 22260tggttttacc attacgcaac atcctcacta aattgtttat ttatattttt aatatctttt 22320attaattcgt cttttaattc tttaggtaac tcatgacttt ttaaagattg ttgttgacct 22380aacgtatatc catattttgt tatccttact tctacagtat accatgattt ttctaaatcg 22440tcaacttttc tagctagtaa tattaaacat ctgtcattta taatattcga agcataactg 22500ccgacacaat gagatagctg ttcaccttct ctttttaatt tttcagtagt atccgcaggt 22560aaaaatttaa ctttagagcc atcgtttaac ttatattctt tatttgtgat attatttaat 22620ttattatcat atttttgttg taactttaag tcatcgactt catctttaac tgttaaatac 22680tcatcagtaa caatatcatg ctctagtttt aaagaatatg gtgttaagtt aatactttct 22740ttagttctat atccaagaag tactaggtct gaagcaaagt ctatataatc tctatataaa 22800ttattaacag cgtatgaatg tatacgttgt ctgtttctga catcatagtt tatataattc 22860accatttttc taaagtcaga aaatgaaaag ttaagaactt ctttcgtagt acctttaaaa 22920gataaagcat ttcctattga atatgaatta gtcaccatta taaagtcgtc atcgaatagt 22980ttgtgtaagt tagactcatt atataaacta ggaaatttat ttatgataac tcgaagtata 23040ttaaggtaat tttcttgctc ttctttacta agagtaataa acttattata tgtttgttta 23100cttaaattta aagcttcatg taatttccat ttatttttgt ttggtattac tagaaactct 23160ttgtgttctt taaatatatc acaatcttcg ttgttataaa ctttatcaat attagacaca 23220actaatttta acagattgtt taaattatca gtagcatttt cacctttact aactgtgcga 23280taaccatcag gtctatctat catagagtat acatcaaagt tttttacatt aagtctactt 23340agatttaagt aataatcatt attctttagt gtttggatta ttatgttaaa agctaaattt 23400tcctttccat atttacttaa aataatattt aaaaggacag gtaaagtaat gttatttttt 23460agtttaccct tattaaaatc atcttcatac atattaaatt taaattcttt atgttgtagt 23520gtatttgata ggtgtaggta tacatttcca tttttattat taaagtcacc gtttactata 23580ctccaatctg ttgttactat acttatgtct tttaaataac aagtcttaat taaaaacgga 23640gtattattat cttttatagg tgttaatttg ttaagcccta tttttatatt ttttaaaact 23700tcattgtagt attcgtagtt attatcataa gatttaccaa atgcataagg gtcaatatta 23760ataccaaata tactatagtc acccattaat aatacatcaa gtatatcatt agttgtagta 23820tttatttgtc tttttaaatc tcttattttt tttgtaaggt agttattact gctcttattt 23880tgcatactgt caaattgttt taattcattt tcatagtttg cacggcagta tatcttatta 23940cgatagtgtc ttttgttata taaaggaaat tcagacctat cgtcactttc tatatactca 24000ctatatacag tatttacatc tgtaactgtt ttacttaact cttgtacttt tttatatggg 24060tctcctttaa acgtagtaag ttttttattc ccacataatg ctataaataa aagcaaattt 24120aaagcactag aataacaaaa ggtattatta atatctctta ataattcttt agagccaata 24180tctacaatat ttttattatt tatttttaaa tatactcttt cttcacctat aaatatacta 24240tttctattta ctttagataa tttaagaatt tcttcttcag ttaatcctgt ttctttatat 24300tctactgaca tgtgtcatca cctcatttat tattatataa gtatgataac atagttaaac 24360ttaatagtca acaaaaaaga agaacttttt tacagttctt ctagataagt ttcatattta 24420atttttttag ttcttcttac gggtacaata tcgggattac tcattaagtc tttgtacttc 24480ttagaatttt taaagttaat agtattaggc attgctaata cttcctctaa ctcatctgtg 24540tacatagtaa ctttagatat tatatctatg tcactaatat ataaactttt agatttactt 24600ttaaaaataa tctcatcggt actagttact tctttattat ctattaaatc catatagaag 24660tcctttctag tctacataaa caagtataca atctttgtct gataaagaca ccgaggtcat 24720atcattaagt tcttgtagtt gtttaataga cacatcatat ttcttactta tagtccataa 24780ggtatcacca tttctaacct tataataaaa tttattacct ttttgtatta agtctttcat 24840tgctatctac gcctttatat tcataataag atgcctgtag gtaacatatc ataataagaa 24900taaagttagc tacttctgta tatattacat gtggtgtcgt atttgttatt aacatactaa 24960taattaaaca agctaatgca atacctataa taagaaataa atatttgcta gttccatttg 25020tacttttagt tttataaaat ttatttattt gggataaata agctacgata atactaatag 25080tagccattat ctgtccatat tcaacactat agttagctac tgaatagcca atataaataa 25140caattataaa cataaccatt tctaaaagac taacttctgt tgttctaaat aagtatataa 25200taaaacaaat aatacctagt aataaattaa tacttactga tataatttga aatagaggtg 25260catgtgttac aaataagctt gttaagctaa tacttactgt aacaacaata taaaaccaaa 25320aatagctatc tacaccttta acattcttat ctcttatcaa acctactaaa gcaggtatat 25380atcctacagt aactaatata gcatatagga tgcttaatat atgagctaaa ttagacatta 25440gatgcaccta acttttctaa ttcccttaaa acttcttccc atgaaataaa acctctaccg 25500ttggttagtg ataaaaccat tccatagaca aactggttcg ttgaaaactc cgctctgtct 25560gggttagtgt atggcttccc gtgcccttga cgaatatcag agcaataaat taaaacaggt 25620ttattgacga tatgatacgc ttctaatatg tcatcttgtg tgtttttatc taactcccta 25680aaatctatat cttcatattt attgataatt tgttgagctt ggtgtttcat acctaataaa 25740atactaagtt ctgctattgt acctagcccc tcattcagaa catcaaacac gaatatatct 25800gactcttgca tagccttaaa gtcattattt aggatacgct cagccaaacc ctcctgtcta 25860gcatttgctt tgtcgttaat tgagccatct tgatgaggag agtatggaga tacacctaca 25920attccttcta cttgattgtg ttgtttttct ctatattcta tcattgcttg attaagtaga 25980tgacctccca tatagcaaat cttatctttg attttattta ccattgtttt tatctccttt 26040ttatttattt aaaagttact ttacccattt tcaatacttg tattctctta tttctctgat 26100tgtagttcta tttacaccat acttttttgc taattctgta tgacttaaat cactcgctct 26160cacttctttt attttttctt catttaactt agcaacaggg ttttttcttt taccacttat 26220ataagaatta agtttgtgcg tagaagttaa ataaagggta aaataccttt ccatcaacat 26280ttttaatatt tataggctct tgatttctat taacaaaacc atatttattt ttcttcttgt 26340atgctgagta acaaccacaa cttctaatag ttttattttt atactggtct tttcttacct 26400ctactatatt accacactta cataagcatt taacatattt acgctttcta tttttacatt 26460gtttaaatag tgtttttatt gggattaaac atgtttcttg taattccatc atacaactcc 26520ctcatatctt ataatttctc cttttctttt tcaaactcat cttttagtgt gatgatatct 26580ttattcagtt cttctgagtc tttcattctt tttttactaa cacatatttc atcaaatatt 26640ttggtcattt tttattttcc ttctcttggt ttcatttgcc ataatttatt ttactttata 26700aaactgtttt taatttatct ttttcttctt tttttcttcc taagtattca tcgttagctt 26760tttgctctcg ttttctatgt acattcaaat aatgttccat tgtcttgata aaacctttta 26820tatttaccta ggtctctagt tgttactatt actttatcag ctctgtcgta tttagtatta 26880cggaatcctt gttcatatat ttttacgtct attgattctt tagtgtaagt tgtgctaaaa 26940gcatcatcaa aataaacagt tacatataac ttgttgtttt ttaaactcaa atcttatatc 27000tttatttcgt cactgttaaa agtgtcgaac attatattta tttcattttt tttaattaca 27060tataaatcat taatagtgta gtttttgcag tacttccctg tcatcttatt ttctttgtat 27120tttttaaaaa tatttttaaa tataattagt accttccttt attttaatta tcaagtactc 27180ttaagtcact tttaagaaca tccatgctat tgctatgttt acctatacca tctagattcc 27240catcttttaa cttattatct ttcatgattt cttttttaat ttgtttttct gtctttttat 27300ttgtcatagt gttttcaata tcaaaagaca tctcttcaat aataagtgtt ttaataaaat 27360caataaattc cttaattgta tatctactaa aataatcttt atcctcaaag tacgtagcac 27420aaaaactttt acgtcttgtt agtacaccta ttgacttatt ggaagtagca atataaacat 27480gatatgtttt tccttttact tttattttaa atcttgtatt atctaacaaa tggttatagt 27540ctttaaataa gtaattgttc aaaattagcc ctcctttgcg ttaacccaaa tttatagtat 27600tttattgtag ttttctctcc gctgtagtaa aggtgtcatt attccaacca ccatcatgat 27660taataaactc taaatcacct gtcacagtac ataagacatc aaaactaata ttttctcttc 27720taccttttga aatacctgtg taaactattt taggtataca actaagggtc tgtaatccta 27780aaccatctat atattctcta aaagatacat gaggtaataa ataagcactc aattcactac 27840tgatacttct actaaaataa atgataatgt ctccaacagg tagttcatca ttatacacat 27900ctacgatatc atcttcttca atagtccacg ttgtatgttc tatatctgca ggtgttacat 27960gaacaagttg tttaactttt ccttgtataa tagactcctt ataaaaacct acagcatttg 28020ctttttctaa atactgtgca ataaaagtac catcatcact aattaaatac ggtgttctat 28080tttgaaaatc tatagattgt tccatatcta gtttttcgta ggtatccttt aagtactcac 28140taattttatt aacatctttt gttttaactt tatttgttcc taccttaact tttaattcta 28200tcattatttt agtctcctta taagtacttt ctaactggtt ccgagtaatc attaatatcc 28260tttactcttg gatactttaa aatactaaaa gcaataatac ctagagctac aataggtgct 28320aataaaacca agccccagaa tgttaatact gtttgtaaga aaaacattac actatctact 28380aaaaaccatg tagctactac tagtaatgtt gtaactgtaa ataaaaataa cttttcccaa 28440aatccacctt tttgaaactt ttttgataat tttttcatca taatatttct ccttatattc 28500caattgcttt ttttgctaat gcatctacat attcattcca tttgttatta tcatgagcct 28560ttacttttat aaaatttata tctataaact ttgagtattc ccttagcata ttaatatatg 28620ttttacttaa attgttttta gttttccacg aaccttcata ccattgaata agtcctatat 28680aatctacatg aataatagcc tgcttataac ctagttttat agcctcttca ataccataac 28740aacaagctag tatttcacct gcaacattat tatacttaat taaactacta ttttcaatag 28800gtttactgat ttcttttaca atgttctcat ttttatctaa aataatagct cctgctccaa 28860caagaccttt attataagat gagctaccat ctgtatatat taatgcagtc ttatgcatat 28920ttatgccctt ctacaaagca agggaacatc tcacttgtat aaatctcttt gtagtcttgt 28980aattttatag tagagaaatc aaaaaactta taacaatgtt cttctgcttc gatatagtca 29040tctgcaataa cattaacttc aaaaccatca actaaaataa cgaacaattt cttaaacatt 29100taaaaaaccc ctttataatt taataaggta cttaattaaa tcaatttcag tgtacttttc 29160tgagtgttct agctcttcta atttttcttt tacttcttca agtctgtatg actcttctaa 29220aagttcaaac tgctctaata atgtgatact atcaaattca ctactattaa tgatgttgtg 29280tatatattct agatgtgtgt ctttaataat gtttgttaag tcatcaccag tataataatc 29340ctcgatatac gataggtctc ctaataactc agccgtactt ctaataatac tatatttaga 29400tatattaggg taagattgat ataaacaatt atctaattta ttacttaaat gctttactac 29460tttttgcatt gtattacctt tttcttcagt actatatgaa attctaatat tagggttttt 29520agaatcataa tcaactaaag aactcctatt agtgtttaat aacttatcta aagaagttaa 29580aataatagct ctatcttcta tattatctaa ggttaagata gtatctataa tagtataaaa 29640tgctttgtct cctattgctt tattaacatc ttgaagttca aaaatattaa tcatatcctc 29700aatctcatga cgctcaacaa agttaataat agattttgta aatttattca tcaacatcaa 29760cctctttaaa taattctaca ctattagtat ttaaagcttt ttctaatttc ataagattag 29820cactcttagg ttttctttta ccactctccc aataagaaat aagtgagtag tgaactccaa 29880tctcttgtgc taaacttcta actgtatgac ctttttcttc tcttactttt tttaaattta 29940atactttagt ctcttccata ataaaccact acctatcttt cttcaatttt taaaatacta 30000tagttatttt tattataagc atacttattt aaaacgtcaa gcgttttttc tttagcctct 30060actttacctt tagctttcat attaacatag aaaacattac ttttatttga acgtgtgtgc 30120ttaatatata ctttgtactg cgtaacctca ctttttaata cattacgttt aaaccatttc 30180tttaattttt ccatttatta taaccacctt taaaacttat atatgtattg tagcatatga 30240taaatacatt gtcaacttaa aaataaaaaa aatactaggg aaaattccct agtacattat 30300ttccagttaa tacgacccca atacttctct tttagcatac gttcccactt gtcagtgatt 30360ttacatactg ccatatagaa gttaccagct gacgggtttg taggatattt aaacctaatc 30420caccagtagc cgtctgcttt aataacttgg tcaaagttta catattgacc actataaata 30480aatgattcag cacctactat tgaacccctt aaacctggtg tgcgtcttac cttaatcgtt 30540ctatcagcag taaatttacc tccccaattc caagttgttt gtacctcgtc tttgaaatta 30600ggttctataa accacatagg aaagtcgtaa ccatgggctc taacggtagc tttctcccag 30660ccaccgcctc cttgagcatc tccccaagtc caacctccac ctaaccaatt attttcaatt 30720actataattt ggttttggtt tgcacttagt acccatgcga catgaccatg accgcatccg 30780tatgaattat taaagataac catagtgcct ggtttaggaa tgtaggatag tgtattttct 30840actactctag ctttatcttt taacatagct ttattatccc atggaatgtt acatgcactt 30900gctccaccta aagaataacc tgggaagagc ttgttaaatc catagttagc taagtcgtaa 30960cattgctgac cataccaacc atcaaagtct attgctttgc cttctagact ttttaaaaat 31020cgaacaaatt cacttctagt catcgatgct ttcaaaagtt ttcactcctt atttccaatc 31080tatttttcca aaatattttt ctttcttaat acgctcttgt ttatctgtta tctcacatac 31140agcacaatag aaataatttt tactagagcc tggttttgga tatttaaatc gaatccacca 31200atagccatct gctttaataa cttggtcaaa ctcaacccaa tcatccttat cgtatagcca 31260tgaatctcta tttactatag tgcctttaag tcctggagat tttctaactt taatagctct 31320atctggataa aaagtacctt tccagctcca catagtttta gtagattgtg tttttactct 31380aggctcagca ttacctgatt tctttacatc tactgactta ataactttct tgtaatactt 31440agctacttcc ttatctaagt tactagtgtt tctacctaat ccacatgctt ctaataagtt 31500acccgggtct tgtttgtcgt tttggatgtc ttggtgacct ggcatatttg ttttgtaatc 31560aacaccccag tattcagcta aataagctaa aacacgagct ccattgtcta atgatttttt 31620agaacgttct ttatcactaa agtaacaaat ttctacacca atagcaccat cattagcgtt 31680aattccgtac cataggtcat ccataggagc gttatacaac acatgccaag ctttttctgt 31740agtaggaaca catatgatag cttctttatc atctacaaag atatgtgcgg atgcagtaga 31800agcccaatca atgttatatg tatttttgta ataatctaca ttattttgag ctgtagtatt 31860aatattccct gtatcatgag ctacaataaa aacgggtttt ttaaccgcca tagcttgacc 31920tgtgcgtctt gttccaatag gcagtaaatc atatctaaca cttacacctt tccaaatttc 31980tatcattact gttcacctac ttcttttggg ttatcttctt tatctaattc agacactaag 32040tctttttcta ctttaccatg ttctaatggt tctgcatgac ttgtatctat gtcttcatta 32100ttaactcctt caggagccat cggcatcttt gtaggaggta actctgaggt actattcatt 32160gcttcactct tgtatgttaa agctttatct gggtcattat aatctctagg tttgttaaag 32220tcctgtacaa tagggctatc cgctatacct ttagtgtcat gacttacaag aacacctaaa 32280ccagtcaaga aactaataac tacacctgca attgcagtgc cttggtttac aatatcttct 32340gcacctttga ttcctaataa actacataca ctgacaataa acgtagctaa aacaggtaca 32400aaacctgtcc aaaatgtagc gctttttgct tttgcagtaa tattgttacc tgctattaat 32460aatggttttt tatctttttt tgacataaaa aaataccatc ctttctgtta ttgtaaagct 32520aataataata taacaaaaag aatggtttta gttattaaat tttaagttat tgttcgttaa 32580tttgagaaag tgttttgatt acttctgaca tttgtttatt atctaagtct tctaacttag 32640tgtgtggaag taaatctaat ttatcccaaa tatctttttt agttgtgaat ttttcattaa 32700taattgctct accgattaaa ctttcagtat aataaatttg ttttgcagat gccatattag 32760tatctaccct tctatagtat aattaaacat acatacataa accgtctcac tggtaagtaa 32820catactagac ctattgttaa gttaatcact acgcttgact ctattaggta gctaacctaa 32880gtccatctca cgtaacctat taaagcagta caaccgtagg gttgattctg tttaatattg 32940taatgtgata ctaacatatt aattagtaac tttcacatgg tatgaagaat tttagcggta 33000ttctataatt tgaccaatta ttattttgca ggtttatgct acttgtacta gtatcgtatg 33060ttatcaaaca tttttcaatg ctccaactgc atatacttgt taaggtgtat ttgtaaagga 33120ttccaccaag accctttaca aaaattaagc ccatcagata ctatacttta taaacctaat 33180atgttactgc tgagtattcc gattgtaata agcattacta ttgacgaatt atctcaccga 33240tataaaccga caagttttaa ttcgttcgac aatctcacgc cttacaggta ccaccctgtt 33300taaatcagcc attatgtatg tatgtttaat aatactactt ttaaagtata acatatattt 33360attcggttgt caagaaaaat ttataacttt ttatagtttt tttatactag ggtaaaaaag 33420ttttaaaaga cctagtttcg acaaataaaa ataaggagaa ataacacctc aatttgacaa 33480caaattaatc tctatgcaag tttaactata atataacata atattctaag tttgtcaagt 33540tcttttttac ttttttatct tgataattct tcttgtattt tatcccaata tttttctgat 33600tctgttctat tatcctcaat gtgagcagtg gtacatttac atctgataca atgtaaatgt 33660tttatatgtc cttcttctct tctttgagct ctttttcttg gtactgtaaa agtattacca 33720cattctgaac aaactaaatt actgtggaac attttctgtc tttttttcat gattatcaat 33780ccttttaaaa ttttttgtat agctagtata tcatataatt attttgatgt caatacaaat 33840actgttgttt tgataaaagt ttattactag ttatatttaa ttattctgaa tatttagata 33900ctttacctat ttggaaaata aggaggactc cttatatata taataaataa ttataaatac 33960taaaataata atactagtta taataattaa taatatatat aggaaagtca acaaagagta 34020ataactggtt cttgataaac tattcaatat tcttacttat atttctgagt aaaaaataag 34080aaatcctttt atatcaaggg ttttaaagat ttttttacct atttggaaaa taaggaggac 34140tccttatata tataataaat aattataaat actaaaataa taatactagt tataataatt 34200aataatatat ataggaaagt caacaaagag taataaaaaa gtgacttact taaaagtcac 34260taattttcaa atactaactt aaatgattct atgaataaag ggttaatgaa tactgtatca 34320gaattaatat cctcagagac tttaactcta actgatgctt gtccatgtcc tctaattgtt 34380ccatttattt ctctttgtgt atactcaata ctatcatcag agattaaata atattttttt 34440ccactaatca ttgttacctc agcatgtttt accatatcaa aactcctaac taaatttatt 34500gaaaatgaaa gttataatag aacctaacac tagtagtagt actttctcgg tagtatcctt 34560ctttcttatg tccttaacaa ctgtattgtt agtgagttct tttatctttt cgtctaatct 34620atctagctgt atgtagatag acgattgttt ctcactatta acagctactt ctttgtctaa 34680actaactacc atttttctta gttcatcaac ttcattttct aattccttat acgtattttt 34740atcaatatag ctaccatctt gtattttatc ttttatctta tctacttgtc cgacaaggct 34800ttttagttct tcattcaact aaagtcacct cttaatgtct accttttcag attctgaatg 34860gacgtcatag ttttcgaaaa agtcattaat aatttgcata taatcctcag taactatctc 34920accatatgat gttttagtat ttatttcaaa cctaagctta ccaaactcat ggaggtctat 34980ttctttaata acggtattag gattatcagt tggtatgtaa taataatcaa aatatataat 35040agagccgttg ataagcaacc tatcaatcct ataaacgtgg aagaattttc tatctcgtct 35100aaagtgagct aaggcatctt taaactctaa ttttaatata tctttatact tagtcaaatc 35160aacttacccc cttataatta attttgagct acactagttt tgtgttataa tagttattgt 35220agtagcagat atgagtatta cgtttaataa aattagcaac caccaactac ctgtacttat 35280taaccataat gaaaaacaag ataatatata aacaaccacc aagtagccta tatatttcat 35340aatgttttta cactctttta atactactac gtatgctagt gatttagata agctaaacag 35400aaaataaaaa taaaaaataa aaagaggtat agctataatg cctgttagta taaccactaa 35460ttacacctaa tttcttttag ctagataata aaatcttata taatacaact ttaatataac 35520attgaaacct gtttataaat caacaatgtt acattaatag tgtacggtat attttaaatt 35580aggaggactg aactaatagg gtgaataata acatagctgt atttatattt aaaactctaa 35640taattattat ttttattttg tttattttgt ctattattaa ctcactgtca ttaatatact 35700ctattcgacc tagtgcagtt atgacttact ttatattcgg tgggatagtt tctaatgtgg 35760cattaacaat aactgataaa ttattattac acaaagaaga ccccttacct gattatattc 35820taaaagaagt agagctaaat aacaatgaat tacaagtact aaagaaaatt gtagagtcac 35880aaactaatgt ttctgctgag gaagtaagag taagagcaaa agcacaacgt cgaatactaa 35940aagataaaaa gagagatgct gtcaatgaaa acgaagaagg acattaaaga acaacgtaaa 36000gagctgaaag ataatgctac tgctgtttcc ttaacaaaaa aaggagataa acgtattgca 36060agtcctagta gagtgtgttg tttatgtggt caatctcttt cagggatgaa ttatactaaa 36120ggtaaagcta tagctaaagt taatcatttt catttacagt actctaagta cttatatttt 36180gacatgtgcg cagatattaa taactgttac aagaatttaa agagagtagg tgaattgata 36240gagtgagcgc tgaaagttta agagatatgt tatctaagaa aaaaattgaa gacgaagata 36300aacgtaaata tatagctgat ggatttatgt caggtattac taaacttatg tatgacttta

36360ataaaaagat tgatagaggg gaaatagaag taaaagaccc taatgatttg tataaagtgt 36420ttgttatctt ccaacaaatg caaaacttaa ttacagatgg ttctgatggt ggcggtgcta 36480taccgcaatt atcaagacca caacaagagc tctttgatga aataacaaat gagaatagta 36540aaggtgagaa agaagtagat ttagagaagt tatctcaact atctgctgat gacattactg 36600ctatgattat tgataaagaa aaggttatga acgaagagaa ctcaaataca ttctaaagaa 36660aggtgtatat gaatggacgg taaagaatta ttaaaaataa cacaagaaac attcggtaca 36720caaagtgtta cacaagaaca agttgaccat attatcaata tgttaaatcc cagtacgtat 36780atgttaaaat atcatacgtt gagaggacac cccattacat ttagtattcc taatagggat 36840agaagtaaag cacaagcaca tagaccttgg caggttaaaa tcgtataatc atttgcgacc 36900ttacatagta atatgtattg aataactctg ttaaacgggc aaagctgaat aatgaataag 36960ctggtaagag aacctaagtc caaacggata gaggcaatcc cgtgctaaat tcttaattta 37020attgttgact acctagacta tgtagtttat aattaaatta agataaatgc ctaacgacta 37080aatttctagg tagctatata aatggataca gtgagaacta gataagaggt ttctataagg 37140ctaaataaaa gaaaggtagg tgtaataatg actagagtac tatcacaaaa atatgtagat 37200aaaaacaaag ataaattcat aaaacgttta gaagatgaga aaaataatga gtaccaactt 37260attggtgaat ataaaacaat gagaacacct acaacattta gacataaatg tggatatgaa 37320tggactacac agccaaaaac tctaatagat gctgaagggc tattaggttg cccacattgt 37380caatacagaa tgaaatcaaa aacaacagaa cagtttaaaa aagacataag aattaaaaca 37440aacggagaat atatactatt agaaggacaa aaatataaaa caaatagaga aaaattaaaa 37500tttaaacaca ttaaatgtgg tacggaattt tacatgattg caggcagtat tttaagagaa 37560caagagagtt atccttactg tagaagctta aaaccttccc caagtaaaag aagtaccaaa 37620tctttcaaaa aggaattatt aagagagaaa ggtaaagact acacactagt atcagaatat 37680acacatgctt tagagaaggt aaaaattaaa catacatgtg gcaatacatg gtgggttaga 37740ccttatcata ttctgtatga caatagttgt ccttattgtt atggctcaac aggtgaatta 37800ttaatagctg gtttattggc aaataaaggt atagattata aaagagaata tatttttaaa 37860gactgtaagc atattgggta tttaaggttt gattttatgt ttattattaa caataatatc 37920attcttattg agtatgacgg agagcaacat tttaaacctg ttgaatactt tggagggcaa 37980gaaacttttg aaaaaactaa agaaagagat aaaattaaaa ataagtattg tgatgacaaa 38040ggatatatgt tactaagaat accttattat tatagtaatg aggaagttaa aattaaaata 38100aataacttta tagaaaccgt aaagcagaga acccttaacc aaaactaagg aatatgatat 38160agtctaaacc gattcttaaa tgaatgttaa agtattacga aagtaacggt agtaaatgaa 38220atgataacca ccctaataaa gctgtaataa agtcgagaca attagggctc agtgaaatgt 38280cagtaatgga aatggttcat tttgctgaca tgtacagtta taggaatgta aaatgtttgt 38340atacatttcc aacacaggaa caacttaaga aatttgtaca gtcacgtctt aatcctgtat 38400tagataaaac ttattttaga gatattgtga attgggataa agactcctta ggctataaac 38460aaattagaaa ctcaagtttg ttttttagaa ctagtagtaa accaagttca gttgagggtg 38520ttgacataga cttcctcgca atggacgaat ttgagagggt gaactcacta gccgaaagtt 38580cggctttaga gtctatgtca agttcacctt ttaaagtagt aagaagattc tcaactccgt 38640cagcacctgg ggtaggtata cacaaattat atcaacaatc tgaccaatgg tactatgctc 38700atgtgtgtca acattgtcaa tatgaaaacg aaatgaaata tgctgattat gaccctaatg 38760acttaaataa gagtggtaat cttttacttt taaacccaga tggtattgat gaacaagcta 38820aaacagtaca agaaggtaca tatcaatacg tttgtcagaa atgtggaaaa cccctagacc 38880gttggtataa tggcatttgg aaagtaaggt atccagaaag aacaaaaaat aattcaggta 38940ttagaggtta ctacatttca cagatgaatg ctgtatggat aagtgcaagc caattagtag 39000agaaagaaat gaatacagat tctaagcaag cattttataa ctattcttta ggtatgcctt 39060atgaagatgt taaaatgcgt gttttaccag aagacatctt tgacaataag tcagaaattg 39120caaaaacaca gttatttaat agagataaat acaaatttat ttcagtaggt atagactggg 39180gtaacttcca ctgggtaact gtacatggta tgactgagga gggtaaagta gatttaatac 39240gtttattctc tattaagaaa aacagtagac cagatatggt agaagcagat ttagaagcta 39300taatattaga gatatctaaa tatgaccctg atattattgt tgcagataat ggtgattcgg 39360gtaacaacgt acttaaatta attaatttct ttggtaagga taaagtattt ggttgtactt 39420ataagtctag cccacgctca tcaggtcaat tatatgcaca atttaatgaa aacagtaata 39480cagtaactgt agataaatta atgcataata aacgatatat acaagattta aaagctaaac 39540gtataagaat gtaccaacag gtagatgatg aattaaaaac ttatcttaag cactggcaaa 39600atgtcctaat catggacgaa gaagatgaaa aaacaggaga actttatcaa gttattaaac 39660gtaaaggcga cgaccattat tctcagtctg cctgtattgg ttacatcggt cttactcgtc 39720taaaagaatt atatgacaaa ggcaacggta cagctttcac atctactttt ataccaacgg 39780attataatag tacacaaaac aactcgtcta atgagttcta ttttgatgac taagaaagga 39840ctgacgactt gacaagtata ttaaattatg atacaataca agaagatgat ataagtaaag 39900agacatttaa tttattaatt gaagagcctt taactttatc ttatgtttct aaacatagtg 39960attctttaga tagtaaatat gactacatat ataaatcact aggctttgat aacttcatgg 40020actgttattt atacatagca agagaaccag aacgtatata caaaggtgga gctaaagaca 40080taggctcatt gaataaagta aaaagaactg tagtacgtaa tgggaaagaa attgaaatga 40140cagtctatga agataataaa aatgatgata aacctaaaga gaataatagt gaagaatcaa 40200aagaacctaa aactgctaaa ggttctaggg ttcttactca tggtgatgct gaaaaaccta 40260atcctaaaaa gattgctagt tctctttcta cattaaagaa taaaggtgta aatactgacc 40320atatagatgg taatgcatcg atatataaag aatttgtaga tgatagtaat aatacaatag 40380gattagcttc ttttaaagag acagattctg acattatatt acatggatac gtatcagact 40440ttgaaactaa tggtgtaggt gctaggtcta tattagagct tatttcttta gcaataaaga 40500agaataagaa cgctgtagtt tatgacatag aactacctca agctgtagag ttcttaaaat 40560ctttagggtt tatgaaaaat aaagattact atgtattaaa aaaacaagat ataaagttat 40620ttttaggtga gtacagtgag cttacttagc actgtactca tttatacaat tatatatata 40680agtattatta tattagtagt tgtaaatgta gtaataagag agaaaagaat gtacaatact 40740aggaagttgc ttatacaagt aaaaaaggat attataaaca acttaaaaaa gggagatatg 40800aatgatcaaa gataataata caaaaacatt ggaagagtta attacaccta tttctacaaa 40860agaaaaagaa aataaagtta aagaatttag taaaacatta tgtgagatga ttaataagct 40920atatagttct tacaatgtat taaggcaaga ccctattgat gaaacacaaa gattagacgg 40980ttctctaatg gtgtttcaaa gtagattaga tgatacatta acaggtgagg aacaccaaaa 41040actttttaaa ttagcttttg attataatat tgatattttt gaagctaaca agcagtttaa 41100agaagatgta caaaatggaa aagctattag gttaggtgat gttgttgtaa ccgacacagc 41160tttaagtaat gttttatcta gtaatgagct taatgttagt attacattta tgttaagcaa 41220agactatgaa gaaaagaaac gtattgaaga agaagaaaag gaaaaactag ataagttata 41280atagatatta tgagaccttt atggataggt aggaataaat aatatgaaac gtaagtttag 41340tagtaatgag attactataa cacttataac tattgtagtt gctctattta taatattaat 41400tacagtagca tttaacaagt accaaattgc taaagaagat aaggacagat atcaaaagct 41460agtagaaatt tatcaaaaag cagatgatga tgacggtaaa actaaaaaaa ggtatgttga 41520aaagttaaat agggctgaag aagaacttaa aaaggttaaa gaagaaacta attataaagg 41580ttataatgat aaaacagaaa aagaaagaga taaagaggat aagagtgtaa gagaacgtat 41640ttatggtaat gataaggata aagatttagt attagtaaat aataaggttg ttgtaagtaa 41700tgaagttact agacctaaga taatagaaga taatggtgtc agtacagttg tagtacctcc 41760tgttgtaagt cctgttgagc caccaagtga acctagtata ccttctccta ctatacctaa 41820acctattatt cctaatccta ttaaccctaa ccctattcta cctaaaccta acatccctac 41880ccctaaccca ctacctccta tagaacctga aaaacctata gaacctgaaa aacctataga 41940acctgaaaaa cctatagaac ctgaaaaacc tatagaacct gaaaaaccta gctcagatac 42000tacgatacct ttagttccat tggaacctag cacacctgta gatgaaagta atgatactaa 42060tggggaggga taacctctcc tttttttgct atattaaaag agtaataaaa taaacattat 42120agttggtgat tttttgatag gattaaacgt acttacagct atatccgtag tttttgcttg 42180tgtaagtcta ctagcactaa tggtatttgc gtatattaaa actgaaaaaa gtagtaagtt 42240ggttctatac ttgatatatg ctataatttc tataggttct tatgtagtat taacaatgtt 42300tcaagccacg tcaatcatta taaaaaatga tgttatagac tctattgaga atacagagca 42360gtatgtaggg tttaataacc ctttaattgt ttttggtata agtttctttg gagctgtaat 42420aggcagtttt tggtttttag ttatgaagat tgtaaatact aggaatttaa aaaataaaaa 42480attaaaggat tgaagcattt gctattttca aaagacgata aatgggatga agcaaaagac 42540tttataaaag gtcaaggatt agcagataat tggatagaag tagtggatta ttatagacag 42600ataggtggta aacatgtagc tatgtttatt gctattgata aagttaaata tatggtacta 42660gaagctacaa aggataataa agtaatattg gtagataagg ataataatat tgtgttagag 42720gattatgata ttgttatgga aagtaagaaa atgttttact atatagaaga accattcgaa 42780gtaaagataa atattcctaa acatatccaa gacattacct ataataacac tgttatacta 42840actactattc gaggaggtaa ataagatagc aataatctat aaaaccttat aaatttattt 42900gcatttttag ataaagtatg ataacgaaaa aagttagatt aaaaccaaat cccacacaag 42960aaaagaaact atataaatcc tctggaacag caaggtttat ttacaattgg gttttaagga 43020aacaaaaaga aaattataaa cgtggtaata agtttatatc tgattctgta ttaagaaaag 43080aaattaccca acttaaaaaa actgaagaat ttaattggtt aaatgaagta agtaacaata 43140tccctaagca agcagttaaa gatgcttgta actcttacag aaggtttttt aaaggacaag 43200ctaagtttcc taaacttaag tctaaaaaga aaacaagacc tagtttttat aatgatacac 43260aaaaactaaa agtaaaagaa aaagtagtct tactagaaaa agtaggttgg gttaggactt 43320ctgaacaatt acctgtagat actaagtatt ataatcctag aattactttt gatggtaagt 43380attggtatct aagtgtttct attgaagaag aaaataaata tgaagagtta accaatgaat 43440ctttaggaat tgacttagga ataaaggagc tagctatatg ctcagatgga attatatatg 43500ggaatattaa taaaataata aaggttaaaa aactagaaaa acgattacgt agattgcaac 43560gtaaggtatc tcgtaaatac caaaataata aagaagggag tacgtttgtc aaaacttgca 43620atattataaa gcttgaaaaa acaaattaaa cacatacaac gaagattgtc taatattcgt 43680aaaaactatt tacatcaaac aacgacttct atcgtgaaaa ccaaacctag aagaatagtt 43740attgaagact tgaatgtaag aggtatgatg aaaaatagac atttagctaa atcagtacaa 43800aaacaaggtt tttatgagtt tcgtagacaa ttagaatata aatgtaaaag aaaaggtatt 43860gaacttacta ttgctgatag gttctttcct tctagtaaaa catgttctaa ttgtggtaac 43920ataaacaaaa acttaaaact atcagataga atatttaatt gtgaatgtgg ttttagtatc 43980gatagagact ttaacgctag tattaattta gctaactata atatttagat tatcactatc 44040atgatactaa atatatgtac cattcgttgt atgggaattt acgcctttgg agtatcatac 44100aaacctaagt agagtatata aaagtaatca gtaatggtga aaatactcaa aaagggatac 44160gctgaaaaag gaataaggtt tataaagttt tataaatttt tgacaacggt aaatgataag 44220ttgcctgatt tatttaaaag tctaaggtta ggtagtatgt ataaagaaga cactgaagac 44280cttatggttc ctatagatga cggaatacaa gctaacatta gacaaataga acaagataca 44340aaagagatgc aagaaattac taaatctttg tatggtaaac agcaagctta tgcagaacca 44400tttttagaaa tgatggatac aaatcctgat tatagagata agaagagtta tatgagaaat 44460gctcataatt tacatgaagt gttaaagaaa tttggtaata actctatact aaatgctata 44520attattacaa gagctaatca agtatctaca tactgtaaac ctgctaggta ttcagaaaga 44580ggagtcggtt ttgaagttaa attaaaagac ttagacgcta cacctggtat taaagaaaaa 44640gaacagatga aacgtattga agaatttatt cttaatacag gtacagataa agatatagac 44700agggattcat tccaagagtt ttgtaaaaaa atagtaagag atacttacac gtacgaccaa 44760gttaacttcg aaaaagtttt tagtcctaaa aacaaaacta agatggagaa gtttattgca 44820gtagacccta gcaccatttt ttatgctact gataaaaacg gtaagataat taaaggtggc 44880aatcgctttg tacaggtcat agataaacaa gtagtagcta gttttacaag cagagaactt 44940gtcatgggta ttaggaaccc tagatcagac ttaaattcta gtgggtatgg attgtcagaa 45000gtagagattg caatgaaaga atttatagct tacaataata ccgaaagttt taatgataga 45060ttctttagcc acggtggaac aacaagaggt atcttacaga ttagagctga ccaacagcaa 45120tctcaacatg cgttagagaa ctttaaaaga gaatggaaat ctagtttttc aggtataaac 45180ggtagctggc aaatttgcct ctatataaag taatttgtat agatgaaggg ttaactgcta 45240agaacaccta aagctcaata cactacaaag taacccgaaa gggtaggctt gaatgttacg 45300aaagtagaaa aaagatattg agatacgtta aggttaaatc ctaagacgaa gaacaatggt 45360tgtttagcat cgaaagtcct aaagaactga aaggtctatg gaatacgttc aacgactatc 45420ccgttacaag acgggagtaa agctccaagc tattgggaga agaaaaatcc ttaccctaca 45480caatagggat aacaaatagt ctagtctcgt actgaaaggt agagcatgtg aaatgacaca 45540ggtttacaaa gtagcgtttg taaataaata aaactaaggt ttataaaaaa aaattattcc 45600tttactagtt gacaattaat cttttctatg atatacttaa accatagaaa agaggtgaaa 45660gtcaatgaag aaactaaaat taagattatt accaactcca gaacaagaag acttaatgtg 45720ggttcatgta aatcatacac gtaatgttaa aaatatattt ttagctaaat gttttgaact 45780aaaagaaaca ggagaattta taagtaaaac cacatcaaat aaactaagat tagaattaac 45840ggaaatgttg aaaacagata aatataagtt atttaaaaag tgtatcaaga gatacactag 45900atagagctgt aaatagtgta gttcaatctt atgttgattg gtgtagaggt actcatggta 45960aacctaaatt caaaaagaaa aataaatgta caaaatactt tgatgttagg gaaaatagat 46020taaaaaggta tggacatact tttcatatac ccagtatagg aaaagttaaa gtatctaaaa 46080atactttaaa gaataatttt agtattataa attctataga aagtttagat aaatttagaa 46140aaacatctat taagtatgat ggtaagtatt ggattatgtt tattacttat gatgacacaa 46200tagttacccc tcgaaaacca agagaattaa ctgatgaagt tataggtata gatttaggta 46260ttaaaacgtt agccacttgt tcaaatggta aatcttataa aaatattaat aaaagttcta 46320aagttaaaaa actagagaaa cgtttaaaac gattacaaag acaagttagt agaaagtatg 46380aaatgaataa gcaaggtaaa aagtttatta aaaccaataa tattattaag ttagaaaaag 46440aaataaaact cttacataga aaacttagta atattagaaa taatcatatt catactatga 46500ctaaagaaat agtagaacaa tatcctagtg aaatagtaat agaagactta aaggtaagta 46560acttaagaaa aaataaacat ttatctaata gtatttctaa agctaattgg tatacaatta 46620gagaatacct tacttataaa tgtgaagata gaggaatatt acttactatt gctaaccagt 46680actacccaag ttctcgaact tgtagtaact gtggtaatcg tttaactaaa caatataaac 46740tatctttatc ccaaagaaca tataaatgtt cttgtggaat taatcttgat agagacttaa 46800acgctagtat taacttaaag aactatagat actccaaatg gtatcacaat catgttttaa 46860ctaaataaaa cagtaaacat gatatgtagg gttccgtaaa cccgaattaa cgcctttgga 46920gtattataac aaaccttagt agagtatata aaagtaacta gtaatagtga aggtactcaa 46980aaagggatac gttgaaaaag gaataaaatt ttttataaat tttagattac gaagtccccg 47040tgatgatggc tgatgatgtt aagtttgtta atatgacacc aacagcaaat gatatgcaat 47100ttgagaaatg gttaaacttt ttaatcaata ttatttctgc tttgtatggt atagaccctt 47160ctgaaatagg attccctaat agaggaggag gagccacagg gtcaaaaggc ggttctacat 47220tgaatgagtc agaccctgct aagaagcaac aacaatctat gaataaaggt ttacaacctc 47280tattaagatt tatagaagaa ttaattaaca gacacattat atctgaattt ggtgataagt 47340atactttcca attcgttgga ggagatacta agtctgagtt agataagctt agtattttac 47400aaaaagaagt acaagtatat aaaactgtaa atgaagcaag agaagaacag ggattgaaac 47460caatagatgg tggagatgta attcttgact cagcattttt acaaagtaca gcacaagaaa 47520tacaaaaaga ccaataccta gatactaaac aaaaagaaag acttcaatta cttatgagtt 47580atacacaacc acaaactgat gagcctacag atgatagtaa acaagaaact actaatcaag 47640aagtagggac agataaccag ttaaaaggtg atgataacgt atatagaaca caaacatcaa 47700ataaaggaca aggaagaaaa ggtgagaaat cttccgactt tatgtagata atattagcaa 47760cctaattaat acttaggttg ttatttttta atttggagct acatttatac tatgttatac 47820tatgtgtgta gtaatgaata atgttgatga tatacttttt gttatattat gtatgtacat 47880ataaaataac aattaagtga ggtgtataat cactttggaa gaaatgaaat ttaatgcttt 47940tgttcctatg gacttaaaga aatccataga tacggaagat gatacaaata aatattctat 48000cgtatctggt tgggcttcca caccagctgt tgatttgcag aatgacatta taaatccaaa 48060aggtattgat atagaatact ttaaaaaaaa tggatatatt aactacgaac atcaacaaga 48120taatgtagta ggtataccta cagataactg ttatgttgat ttagaaaaag gtttatttat 48180agaagctaag ctatggaaag atgatgaaaa tgttataaaa atgttagacc tagctgagaa 48240actagaaaag tcaggtagtg gtagacgttt agggttttct atagaaggcg ctgttaagaa 48300acgtaacata aatgacaata gaattgttga tgaacttatg attacagggg tagcactagt 48360aaaaaaccca gctaatcctg aagctacatg ggagagtttt gttaaatcat tccttactgg 48420aacggaaaca acaccagaca cacaagtaga tgcaggagcc ttacgtaaag agtcattagc 48480aagctctatt actaatttaa cctatgtaac aaaaattaaa gatgttaaag agtataatga 48540tatttggaat aatgtagtag aggacttaac taaatctaat aatatgggtt atgaagaatc 48600agttattaca ttacaattag ccaaaggact atcaagaaaa gatgctgaga tagcagttat 48660gagtattaat aaaaaaaatt tagaataggg gattatatta tatgcctacg gaattacaaa 48720atattctaca agaatatgat aacttagaca aagaagaagt atcaaaatct gtagaagagt 48780ctaaagaaga agtaaaagaa gaagtaaaag aagataaaac agaagacact aaaatagaag 48840acactaaaac agaagacact aaaacagaag aaaaagaaga aattaaaaat gaagtagaag 48900ctacagaaga gcaagtagca gaagctaaag aagaaccaca agaacctgca aaggttactg 48960aagaagatgc taaagaagca catgaacaag aagaaaatct agaagaagaa gtatctaagt 49020cagctaagga gtcgaaagac cctgtagata aaaaagatac taaaacagaa gacaaagaca 49080acgagaaacg aaaaaataaa aaagacaaaa aagaagaaaa agatgaagaa gaggaagaaa 49140aaacatctaa atctatttct gataaagata ttgtagatgg tttccgtact atcttgaaat 49200cattccaaga cattaaaaaa gaaaatgaac aatatgtgac taaatcagat ttagaagaag 49260taactaaatc tattcaagct ttaactgata aaattaattc taatgaagaa gtttctaaat 49320cagttgagag caaccaagaa gataaagaag aagcagtaga aaaatccgta acgactaata 49380acacttcgaa tgaacaagat gtagttggtt atgtagctaa atcagtacaa acagaagaac 49440aagcagaaac tacagaagat aaagaagaac aagaagtaga agttaaagaa gaaagtagag 49500acttatctgt agaagaccgt gaaaaattca tgagtaccta taaagaaaaa tctcaaaacc 49560cacatacgaa tcgttcagaa gtattgaatg cttatcaagc ttacttaaat atccgcaaca 49620atccagagca agcaagtgaa aaagacttta atattgtaaa agaatttgct aatctttaat 49680taagaaacaa agttgtgtta tattatagtg tgtaaaataa aacaataaaa aaaagagcat 49740atatgaaagg tgatatatat aaatgaacca aaatgaactt tcaaaaaagc aacatgcagt 49800tgctgatgaa ttacaagaaa aattatcgaa atccttccaa actggatatg gtatcactcc 49860tgaaacacaa gtggatgcag gtgctttacg tcgtgaaatt ttagacgacc aaatcactat 49920gcttacatgg ggaaataatg atttagtatt ttaccgtgat gttgcacgta gaccagctga 49980atcaacagta attaaatatg atgttttctt acgtcacggt aaagtaggtc attctcgttt 50040tgtacgtgaa atcggagtag cgtcagtttc agaccctaat atccgtcaaa agaccgttac 50100aatgaaatat atttctgata ctaaaaatat gtcattggca tctagtttag taaataacat 50160tgctgaccca ggtcaaatct tgactgaaga tgctatctca gttgttgcta aaacaattga 50220atgggcttca ttctatggtg acgcaagctt aacttctgaa gttggtggag aaggtttaga 50280gttcgatgga ttagctaaat taattgatgc tgataacgtt atcgacgcta aaggtgctca 50340cttagatgag aaattattaa acttagcttc agttaaaatc ggtaaaggtt ttggtacagc 50400tacagatgct tacatgccta tcggtgtaca ttctgacttt gttactaata tcttaggtcg 50460acaaatgcaa ttaatgcaag acaatagtgg taatgtaaat actggtttca gtgttaacgg 50520attctattca tctcgtggat tcattagatt acatggttct actgtaatgg aaaatgaatt 50580aatcttagat gaaactttaa tcccacaacc aaatgcacca caaccagcta cagtaaaagc 50640tgaagtaaaa acaaaccaaa aaggtaaatt tactaaagaa gaagaccgtg caggtttatc 50700ttataaagta gttgttcact ctgatgaagc tgaatcagca ccatcagaag cacaagttgc 50760tacagtaaca aatgctacag atggagtaga attaaagatt actgttaact ctatgtacca 50820acaaagccca caattcgtat ctatttaccg tcaaggtaaa gaaacaggta tgtactactt 50880aattaaacgt gtagcactta aagatgcaca agaagatggt tctttagtat tcgttgataa 50940aaatgaaaca ttacctgaaa cagcagacgt attcgttggt gaaatgtcac cacaagtatt 51000acacttgttc gagttattac caatgatgaa attaccatta gctcaaatta atgctagtat 51060tacatttgca gtattatggt atggtgcttt agcgttacgt gctcctaaaa aatgggctcg 51120tattaaaaac gtaagttatc ttgcattaaa atagtaaata caattaaaaa ttgaatacaa 51180tagaataagg agtataccta agggttgctc cttttttatt attacttata gtatacaaga 51240aaggaattta aaaatcaatg ttaacttata aattaaaaaa tattaaaatg gctactgtac 51300atggtcaagt agaagtagat gataaaggcg tagttaaagg actaactgct aaacaagaaa 51360aagattttgc taatttacca ggttttacac atatggaaga caagaaaaca acaaagaaag

51420aagtaaaacc taaggaagaa aaagaagaga agaaatcaat taaaaaaaca actaaaaaag 51480aagataagta ggttgataga atggtaaaca gtatgtttgg tggtagttta gacccttacg 51540aaagctcttt atcatatgag tatccttatc acccatctgg aaacccaaaa catatagata 51600aaagagaatt agatagtatt actctagctg attatggttg gtcagcagat gctgtgaaag 51660cctatatgtt tggtataaca gtacaaaacc ccgatacagg acaacctatg ggtgatgatt 51720tttataatca tatattagaa agagctatag gtaaagcgga aagagcttta gatatatcta 51780ttttacctga cttacaacat gaaatgagag attactacga aacagaattt aatagttata 51840tgtttgtaca cgcatataaa aaacctatat tacaggtaga aaatttacaa ctacaattta 51900atggtagacc tatgtatgat tatccagcta actggtggaa agtggagcat ttagcaggtc 51960acgtacagtt attccctaca gctttaatgc agacgggtca atctatgtct tacgatgctg 52020tattcagtgg atatcctcaa ttagcaggaa tgtacccccc aagtggagca acttttgcac 52080ctcaaatgat tacattagat tatattagtg gtatgttacc tagacaaaga gcaggtagaa 52140ctaaaccatg ggaagtacca ccagaattag agcaattagt tattaaatat gcactaaaag 52200aaatttacca aatatggggt tacgatgata ttaccctgtg tgtagcgtaa gttgcacatt 52260ttcaaaggtt aactgctaag aaatcctaaa gctaactaaa ctacaaagta atctgaaagg 52320ataggcttga atgttgagaa atcagaaaaa attagttaga tactctaagg ttaaatccta 52380aagagaagag caatggaagt ttagcatcga aagtcctaag tcaatagata aggaatacgt 52440tcaacgacta ttctgtatag acgacagaag taaagctcca agtgattggg agaagaaaaa 52500tctttaccct agtcttaggg ataacaaata gtctgcacac gtcttgaaaa ggagtgctag 52560gaattgacct agacttattt agtagcgtaa gtaaggaaac aatgttaatt aaatgaaaac 52620ttcctattga aattacccca agtatatgtt atattataga tatagtatat aaggtggtga 52680aagtaaatga aaaaaacgga aaatacattt tatagaggta taacactaaa agtaaaccct 52740acccaagaac aagaagagtt aatgtggaaa catgtaaacc attctagatt tatttataat 52800tatatgttag aaagatattg gaaagctctc gataacggta aatatataga ccataaaaat 52860atgatttcta tattaaaaga aataaagaat gatgataagt atagtttctt aaatgaagta 52920tctagaaaaa ccttagttgg taaaatagat gacttaagag aaacattaat aaaatatcat 52980aatcatgaaa ttagaaaacc taaatttaag tctaagaaaa gggaatctaa gaggtttcct 53040attagatatg accgaatgca ctttaacaaa gaaaaacatg ttaaagttga aaaattaggt 53100tacttaagaa tttctaatgg tacatataaa aataataaat cagtactaga gaatgaaagt 53160attaaacctt taaaccctaa atgttactat gatggtaaat attggtatat atccttttca 53220atagaagtag ataatcaata caagaaagaa aaggataata ctaacgaagt cataggtata 53280gacttaggta gtggtaaaaa acacgtaatt tgttctaaca gaaaaatata tggtaatatt 53340atttattcca agaaaatgaa aaggttagaa aaaaaattat ctgacctaca gaaaagatta 53400agtaataaat atgatattaa tcacaccaaa acaaataatg ttttaaagct agaaaataag 53460atagctaaag tttatagaaa aatgtcaaat atccgtaaaa atcatgtaca tgaaataaca 53520aaagaaattg ttgaaaagta tcctaaagag attattgtag aggatataag agttcgtaat 53580ttaataaaag acaaaggata tacaggacaa aaaagaaaac aaatacagtt ttctaatttc 53640tatatgatta gacagcaatt acaatataaa tgtgaagata gaggtataaa atttacagta 53700gctagtactt attatccatc atcacaaata tgcagtaatt gcggagaaag aaaaagaaat 53760gctttaaaat tacagttagg tgataaagtc tttaaatgta atgcttgtgg atatgaagaa 53820gatagggata taaatgcaag tattaattta aaaaattacc ataattccca atggttaaaa 53880gaacaaaacc aataatatgt ttgcttttag tagggttcca taacccgaat gtataatgcc 53940ttttatttta caaaggaagt taatttaatt aacatatggt aatctcatta tcggtgcagg 54000aatagcaaat aaaactctag atgtagatgg tattacagaa acaataggta ctacacaatc 54060tgctatgtat ggtggagcaa gtgctcaaat actacaaatt aatgaagata taaaagagct 54120attagctggg ttgaaatctt actttggctc caatatgata ggcatatagt aggaaggaga 54180tattaaatgc aaaaaccttt tatgataggt actaataata ataatacttc taatataatt 54240aataagtcta ctatgtatat atctacaaca caagcagatg aacaagaaca aaagttatct 54300acagctagac tagagtttga cactaaggat atgagaagat ttgtcaatga tagaggtata 54360aaggtactgt gggaaagggc ttacttttgt ccttgcctta accctgacac aggacatcct 54420agagtagatt gtcctaggtg tcacggtaaa ggtattgcct atttacctcc taaagagaca 54480ataatggcta tccaatctca agaaaaagga actaacaatt tagatatagg aattttagat 54540actggtacag ctataggaac tacacaatta gaaaaacgag tatcttatag agacaggttt 54600actgttcctg aagtattgat gccacaacaa cttatatacc atgttactaa agagcgtata 54660caaaaaggta tacctctata ctatgatgtc aaagaagtaa cctttattac atctaacgat 54720ggtaatgttt atgaagatga ctataatata gagaacaata gattattcat ggacgctaag 54780tttgaaaaca aaactatatc cttaaatatt ttaatggtac ttagatatgt agtatcagat 54840atattaaaag aaagtcgata ccaatatact aaatttaatc aacctaatac aaagtttgaa 54900aatttacctc agaagctatt attaaaaagg gaagacgtta ttgtactacc tgagccattt 54960aaagttaatg atggtataga agaggactta gagatacagg tagaagaccc taaaaaagaa 55020tctaaagata atcattcagg tggtttcttt gggggaatgc tataatgcct ataaaagcaa 55080ctagacctaa gttatttaga gacaagagct ataaaaatgt aggtaagaga acagtagatg 55140ctatgcgttc tgatatttta gatagattac aagctacagc attacaagta gataatgtga 55200gtgtcaaacg tatgcctacc tacttacaaa taactgagca gaaactagag aagaaaggtg 55260taatagacct taaaaaagct tttgcacgtt catctaagaa aaaaagagca aaagatggtg 55320gttggtatct aacggttcca attagaataa aaacaagtaa aatgaataat aaaacatacc 55380aagatttaag gtctttaaaa ataggcagtt caagtaattc agtatctact cttactgatt 55440atctagaagg tagacgtaat aacataagcc atccttcttt aaaagtacct agcagtaatg 55500gcagaataac aaaagtaaga aatggtaaaa aatctagtta ttttatgttt agaacagttt 55560ctagtaagtc acctgcaagt tcatggatat taaatagaga caaagttaac gagaataatt 55620tctctaaaac aacattaaaa tatgttagga atttaatgaa ttggaaaatt aaaaatttaa 55680tgtagaaagg ttatggaagt aggatggcaa taacatcagt agactcatat ttattagagc 55740aaataaaacc cagattacat acagtactaa gtaattgtta tattatagat gaagttttaa 55800aagactttga ttatcaaact agggaaatgt tcaaagaggc tttttgcggt gagaacgcaa 55860agcacgaagt aacagtaggg ttcaatttcc ctagctttaa aaacaactac gaagctcatt 55920acctaataca actagggcaa ggtcaagagg ttaaaaactc tttaggtagt atacaggggt 55980cttatctaga agcttcgggt aacacatata gtgaacaatc agtagctaaa agagaaggta 56040atcgtttagt atttcatgta tctaaaccta tttctaatgt aataagagta gaagacatag 56100cgtttgattc ttacgatgat gttaaagtat cagataacac tgtatctttt aattatacta 56160acaatgagac ttatgaaggc tacaacgcaa atattgtata tgtagaaaaa acaaatgata 56220gtaaagggtt agtaaaaggt attaccatag aagaacaagt aacaattgtg ggtatgtcgt 56280ataatgtaga tgttgctaga tgtttagatg ccgtattaaa aatgatattg atatctatga 56340gagatagtat agaagaacaa caaacattcc agctacaaaa tcttgcattt ggagatatcg 56400cacctatatt ccaagacggt gagtcatcta tctttggtag acctactata attaaataca 56460caagttcatt agatttagat tatacaataa cacaagatat taataagatt actttcaaga 56520ataaaggagc aaaaagataa tggctaagaa aacacctaaa ggtaaaacct ttacaggtta 56580tgtacatata gatacatttt taaaaacagc acagaccttg tttaatatga aagagtcaca 56640ggttgcaggt tttaaagcct atatggaagg taaacattac ctattcaatg aaaaagactt 56700tattccattt ttagaaaagt atttaggtag agaattagaa atttaatata gagataggag 56760aattatacat ggcagttgaa ccgtttccaa gaagacctgt cactcgtcca catgcagtca 56820ttaatgtaga tagtacaggt atcggtaaat cagctagctc cagtgaaaag attttatgtt 56880taattggaca agctgaaggt ggtaaacctg ataccgtata tgaattaaga aactacgcac 56940aagctaaaag actattccgc tcaggtgaat tacttgatgc aattgaatta gcttggggtt 57000ctaatccaca atacacagca ggtaagattt ttgctatgcg tgtagaggat gctaaaccag 57060ctacagctga agtaggcgga ttgaaagtta cttcacagat ttatggtaac gtagctaaca 57120acattcaagt aggattagaa aaaaatacaa tcagtaattc attacgttta catttaatct 57180tccaagatga tagatttaat gaaacatatg ataatattgg taatatcttc actatcaaat 57240ataaaggtag tgaaagtaca gctacttttt ctgtagagca tgataaagaa acacaaaaag 57300caaaaagatt agtattaaaa gctaatagca cagaagttaa gtcttatgac ttaacaggag 57360gagcttacgc tactactaat gccatcatca acgatattaa ccaattacct gattttgaag 57420ctaagttatc accttttgga gacaagaact tagagtctta cttattagac cctatgacag 57480atgttgacat taaggataaa gctgagtatg taaaagcagt atttggtgac ttagagaaac 57540aaacagctta taacggactt gtttcatttg aacgattagt atctgaacaa gcacctaaaa 57600acgtagaagt agacgcacac gaagagtctg ccactgtaac agctgtatca ccaattcaag 57660aaatcacacc ttttgaatta acaaaacttt cagggggtac aaatggtgaa cctcctgcta 57720catgggcgga taaaatcgaa aaatttgcac atgaaggtgg atactacatg gtaccactat 57780cttctaaaca atctgttcat gcagaagtag cttcttttgt taaagaacgt tctgatgcag 57840gtgaacctat gcgtgctatt ctaggtggag gatttaatga aacgaaagaa cagttgtttg 57900gtcgccaatc atcattatct agcccacgtg ttgctttagt agctaactca ggtatattca 57960caatggacaa tggtcgtaag ttacatgtac cagcttatat ggtagcttct gctatcggag 58020gtttggtaag tggtttagct ataggtgaat ctattacatt taagcaatta catattaata 58080atgtagacca attatatgag tcattagact tagatgagtt aaatgaaaat ggtatcatta 58140ccattcaata tgttcgtaat agagctaata cattctttag attaacagac gatgttacga 58200catttaatga taaaaatgac cctgttaagt cagaaatggc tgttggggaa gcaaatgact 58260tcttatgttc tgagttaaaa cttgagcttg aaaataactt tattggtact cgtactatca 58320atacaagtgc ttcaattatc aaagactttg tacagtcatt cttaggacgc aagaaacgag 58380ataacgaaat tcaagacttc ccacctgaag acgtacaagt tattgtcgag ggtaatgaag 58440ctagaatctc aatggttgta taccctatca gaagcttcaa gaaaatttct gttagcttgg 58500tataccaaca acaaacatta agagcctaaa ctaggacaag gagtacctag tttaggtact 58560cctattaaat ttaataggag agtgaattaa tatggcttca gaggctaagc agtctgtcca 58620tactggtaat accgttatgc taatggtaaa aggtaaacca gttggaagag cacaatctgc 58680taaaggtcaa cgtgaatacg gaactactgg tgtatacgaa attggtagta ttatgccaca 58740agagcatgtt tacttaaaat atgctggtac aattacacta gaacgtttac gtatgaaaaa 58800agaaaacttc gcagatttag gatatgcttc acttggtgaa gaaattctta agaaagatat 58860tattgatatc ttagtagtag ataacttaac gaaacaagtt attattagtt accatggatg 58920cagtgccaat aactatgaat cttgtagctt ctagaagtaa ttctagtcga aaaacttttc 58980taaacaggga accctaagtt acaatgtaat atgggaatct tgtgctaaat tcagtagata 59040ctgataaatg ccaaacgact aaccgaaacc tacttacagt agtaagggga gtaggtgtac 59100agccaagtgg tcagggtgtt gggtaattac catataaaac cttgctaagt ggaaaagaaa 59160agagtcctcg attgaggatt gtgatatagt ctaaccttta tggaaacata aagcagttca 59220taagagaacg gataaagatt aacgaccttt attgaatatg agtgaatgag acttggcaaa 59280caaatgaaat tgtaactgaa gaaattgagt agaagaatgc tcctttaact agaaatagtt 59340atagcaaatc cctttaattc atgggaaccc ttaacagata atgctgaagg caatcatgag 59400ccaagcctag taaattacta ggaaggtgca acgactagtc ataatgacgt acatctaagc 59460agatggaaat gggggacacc ttcaatatta aggtgaagat atagtctgaa ctatatagaa 59520atatatagaa ggttcgagag tagcgttttg aatcgtaaca aatttgtttc ttatttaaca 59580gctagtgata aagcccgtac ctaaagggtt taaagaccta acaataaaag ttaggtcttt 59640ttttattgac atataactaa cgatatggta acattaaaat ataatattag agaggtgtta 59700agaatggata aaaaaataat aggattaaat acaaaaacat tagaagagaa ggtttttact 59760actataaaag aagcagaaaa agaaattgaa ttaagaggta ccgttaaaag atgtttaaat 59820aatgaaatta agtctactaa aggatggtta ttcaggtatg aaaatgaaga ttttccggag 59880aaggcaagaa caataacaga caaaagaatt aaggttgttg ttttaagtaa agagcaggaa 59940caaataaagt tacctcttga gatggttaaa aatttatatg gaatacctaa acctatgatt 60000attgaagcta ttcaatataa aaggaaaatt aatgactact ctgttagaag agctacaaaa 60060gaagagcaaa agattacatt atctaacatt agttatatag actatataaa aacagttaat 60120aacccaaaca atattaaaat tattaaaaat aaaggttctt ttggtgaaca gttagttaag 60180atagtattag actataataa tatagaatat aaaagagaat attcttttaa gaatgaatta 60240gggacagtac agagaatgga ttttttagca gtagtagata ataaaaaata ctgtattgaa 60300tatatgggtg agcaacatta tgtagaaaaa ggtaataagt ggggctcgtt agaaaagaga 60360caatttctag attctataaa gaaaaagtac tgttacgaaa atggaatata ttatattgat 60420atcagttata aaaatagtga tttagagagt gtatttaatg ttattaataa acacatacca 60480ggtattaaaa aaccaaataa atctattatt gatattggtg tgacaataaa tatagaagaa 60540atgttagaat actataagga gcatactaaa aaagaaacag cttataagta tggagtaaag 60600gaacataata ttgataactt attagtaaat ttaaactatg aaagcaaaag aaaacctaaa 60660gatataatac aagtatataa gagagatgaa aaaatatttg aaggtactta taacgaaatt 60720aaggatgaat ttaattttac tatgagtaat gttttgaaat gcttaaatgg agaactagat 60780aaaacatcac aacattactt taaatataaa gattcagaaa aagataaagt tagacaacta 60840aaaactaaag aaagacatgc taaaagagga acagtaagag gaagtagtaa caaagatgtc 60900gttctaaagg acatatactc aggagaggaa actatatatt cttctattaa ggagtgtcat 60960gaaataacag gtctaaacaa agacaaattg tacaagttat ttaatccaaa taaaagtaaa 61020caaattgtag acaaatatat aggtaaaatc tacggtggtg agtaccctat aactgtagaa 61080gaggctttaa acataattaa cccttgaccg atatcaaggg ttatgctatc ataataaata 61140aggaggtatt accttgacaa acagaaaaac aattggtaag atgagtaata caagagcaac 61200atggaagata aaacctgtaa ctaaaataac aaaagataaa acaaaatatt ctagaaaaaa 61260gaaacataaa ggtattgaca cttataaata actgtagtac tatagttata taaggagatg 61320ataaatcatg aaaacttttt attcaggtag aagaacaaca agtaaaaata ggcaagtaaa 61380gaagcattat aaacaaatga ctaaccaaga aataactgtg tgtagaaact tattaaaaga 61440atcttataat aaaaataatt actttaagtt aacaaatcac tttaaaggta aatgtaagaa 61500accagtaaat tttaaagcgt ttgttcatta catacataat aagaacttag atattataga 61560atataatgaa acattatata ataacaaaat acaacgtagg gtagttgtta gacatcctta 61620tgtagtaaaa gtagataata aattatctta tcaatatcta gttatagaga tagaaacagg 61680tgaagttgta actatgtatt ataacagagt tacagacaac cacagaacat taaatttaaa 61740tgactattat gataaaaatt taaaaataaa gtattgacat aagtaaatac ataatatata 61800ctaaggttaa attaataaag aggagaataa aaaatgacaa ataaattaag agctatccat 61860gaagaaatga aaattgagtt acataaattc ccacagaatg tagatttaac aagtaagaca 61920actgctattg caatcaatca aattcttgac aagtttaaaa ccttaacgga acaagcaggt 61980aaaatcacta aaaagtattt tgagggtcaa gagattttga cgattgattt tgaatattat 62040gactcacttc aagattacta tatttactta cttaaaaata gtgaaacaat cgaacaaaga 62100ttacaagaaa ttgaaaaaag agtagctgaa tatgttaagt aatttggagt tataaccaca 62160ttatgttata ctgtatgtgt ataaaaaaca taagttagct gttatattaa ttatgagaaa 62220ataataaagg atggataaag aattggaaaa agaacaaaaa gatattaaag atatgacacc 62280tgaagaaatt gatgagttaa aatatcagca acgaaaagat aaagagcgtg ttattaacaa 62340agtaattaaa ggtgttaatg atgtatggga gaaagaatac aactttgaag aattagattt 62400aaaattcaaa gtaaaaatta gattacctaa tgctagagaa caaggtaata tcatggcttt 62460acgttctgca tacttaggtg gaatggatgc ttaccaatct gaccaagtta ttaatgctta 62520tcagatgtta gctactttac aagaagtagg ggtagaagta cctaaagaat ttagagaccc 62580tgaggagatt tataatctaa ctccgcttgc tattatgtgg gatgattggt tagactttat 62640gacgtccttt cgttactagt aacgtaaagc agttaaatga agatatagaa cggttaggtg 62700gaatttcaca tatagctaaa gagcctctat caagaaacct atgggctatt atgcgtgagt 62760ttaatgtatt acctactgaa caacgtttta aagatttaga tgattaccaa atagagttta 62820ttatagctaa catgaatctt gatacaaaag aaatgatgga agctagagaa ggtaaaaact 62880atgatatgaa agcggaagac gtagacacat catggttcga agcgccgaca gatgaatttg 62940atgttgttcc tgatttctta gacttagatg atttaaatac acaagtagat aaaagtttaa 63000gtgagaaaga aaagatagaa agggatagac gagttgaagc tgagttagaa gatgaaactg 63060aaggattaac aactcaacat ttggctatga tggaacacat aagacaaaaa caaaaagagc 63120ttgatgaaag tttaggtatt gacagtaaag aaataacaca agaagatata aacaaagcaa 63180taaaaaatgt agatgattgg tacatgtagg gtaatggtat aataccaata cccttatttt 63240ttgattaggt ggtgaatact gtttggcaat gaatgacgat tataggttgg tcttgaccgg 63300tgatagttct agtttagaac aaagtttaaa agctatagag atgtatatgg atgcgttaga 63360gtctaagaac atagatgcac cattaacaaa cttcttagag aaactaaaag taatagcaaa 63420agaagtaaaa tctgtacaaa atattatgga taagcaaagt gataaatctt taatatcacc 63480aaaagctatg gacgaggcta ttagttctac acagaatgta actaagaaca taaatgacct 63540aaagagagct ttaaatgaca tacaaacaga taatattaca aagggtatag ctcctgaccc 63600tgaagtagag aaagtataca gtaaacttaa taagacacta aacaatacac aaacagaact 63660agagaaagta gcatctcaaa agattggttc agactcagat gtaacaaaca gaataaaaga 63720aatgaaaaca ctgaaccaag ttacagaaga gtataataaa ttagtaaaag atgccagttc 63780agctaaggag tacacaaagc aactaagagc taatcgtaat atggttaggg gtcatatatc 63840taggtctgaa ggctctaata gaatgtccta tgaccaaggt gctagagtac gttctgaatt 63900aggtaaagta gacacttttg aaaagcaacg agaagctaac aatagaagaa taaaagaaaa 63960ccaagataga tatagaggtt atagacatca acaacaagat ttagtaggta aaagagctcg 64020tggtgaaatc agttctgaag actataaaaa acaatcagca tctattaaaa tgatgattga 64080tgaaagtgaa aagctttctg aagtctatag aaaaacaggt gctgaattag acaagtcaat 64140caactactat aaaaatagtg ctaaaaaaca gtttgctcag cgtgagatag aacagcaaag 64200aggaacaatg ggtaaattgt ttcaagatag gttaccttct attggtgcac atgctactat 64260ggcagtaact gctcttgcag gcggtatgta tatgcgtggt gcttccctat ctgaagcaaa 64320tagacctatg gtaacatcat taggacagaa ttcagataat atggacatag atgcagtaag 64380aaatacttat ggtgatttat ccatagataa taagcttggt tacaattcaa ctgacgtgtt 64440aaaaatggct acatcatatg aaagttctat aggtcataaa agtgatgcag atacatacaa 64500aggagctaaa cagttagctg taggtggacg ctcattaggt atacaagacc aagaaatgta 64560ccaacagtct atgtcacaac ttatgcatac aggtggcgta aattcagata atatgaaagc 64620tatgcaagat gctttcttag gtggtatacg tgaatctgat atggttggta gacaagatga 64680acagttaaaa gctttaagta ctattgccga gcagtcagga caaggtagaa cattatctaa 64740aggagacatg tctaatctta cttctttaca agctcaagta gcgggtacag gtagtaaagg 64800tttacaagga gctcaagggg ctcaagcgtt aagtagtatt gatcaaggta ttaaaaatgg 64860tatgggtaat tcttatacta ggttatccat gggttggggt actaagtacc aaggattaga 64920aggtatgcat gacttacaag cacaaatgga taaaggtata tcagacccta ataacttagt 64980taatatattt gaccaagcta ataatatagg aagtacaaca aaagaaaaac aagccatagc 65040taaaaaaggc tttgaaagca tgggagctaa tttaacacaa gagcaaacag atgagttgta 65100caatctttac gcctcaggta aactatctaa agaagagtta gctagtaaag ctaaaaagat 65160ggagcaagaa ggttccaaag caggagataa gaatagggat aagtattccg aatctaaagc 65220aggtaggaat gaccagaaca aagctaagac agatgataaa gccgaggata tttatgactt 65280agctcaacct attagagatg ttcatagtgc tatggcaagc ttgccagctc ctttatacct 65340agcttcagga gcagtacttg catttgtagc atctttagct aaatctactg ccatgatggc 65400tggtggctct ttattaggta aaggtcaaaa aggactaaaa gattggttta ataaccgtaa 65460aggtggttca ataggtaaga ctggtggtgg gcgttttggt ggacttaaaa acttagctga 65520cactatacta ggagataatc ctaaaggtgg agaccgacca tttaaagacc aagtaaaagg 65580tgcaggacaa actgctaaag gtatgggtaa aaccctattt gataccttcg gaaaaagaga 65640ctttacattt ggtgaatata tgggaagaac caaagactta ggtaaaggtg catggaacaa 65700aggtaaagga gcttttggta aagctaaagg taaatttagt ggtaaaggtt ccaatttagg 65760ttttatgtca caagcaccta ctgctaacgc aggtggtctt ggtaaactag gtggtcttac 65820aagtaagcta ggttggattg gtgtaggtct atcggcgttt gatataggta gttctttaat 65880acaaggagat actaaagaag cttcttctaa atttggtaac actataggaa gtgtcataga 65940cccattaaac ctaggttatg gagacggatt aagagactat gctacgaaaa cagcagaagg 66000tgcttcgaca ggtgatggtt ggaaattatg ggctaatgga gataaagatg gtaagaataa 66060attccaagac tcacctgtag gtaaactatg gggtggcata acagatttct tcacaccaga 66120tgacccttct aaattagatg aaacagtgaa aaataaaaaa ggtaacataa ttagttatat 66180actaattgcc ttgcttatag agcaatctgt aagtaccgag tgttaactgc tatgaaacta 66240ctaaagctaa ctaaactaca aagtaagtcg aaagactaag cttgaatgtt gagaaatcag 66300aaaaaattag ttagatactc taaggttaaa tcctaaggag aagtacaatg ggtgtatagc 66360atcgaaactc ctttaacatg gagaacgttc aacgactatt ccgtataggt gacggaagta 66420aagccacaag tgattggtgg aagaaaaata ctcaccctat aaactaggga taacaaatag

66480tctgcacacg tagggaaacc tagtgtctag aaataactag agaatataca gtagcgtgta 66540tatttaaaca ttgttaaaat atataaataa ttaaaatttg tattctactt ctgcatataa 66600acctttctta ttttgtaagg taaacttgtt attaaataaa tatacataac taatacgata 66660ggttatatat gaaagtatac tattgtttat atgttttaac ttatggtatt aatgataaat 66720cacaaagtaa agacaggcaa aaagcagaag aaaaaagaga aaagaataat gattctagag 66780aaggaaatgt aacagtatac tcacatttct tagaccattt agcagacaat ctaacaaata 66840aaggcagtag ttccgacaat agttcatcag gaggaacact tgactatctt gatggtaaga 66900actttacaga taaagacgta actaagcatg acttaggtaa aactgctaaa ggtgtaaatg 66960ccgaaatgtt aaataaatgg attgagtctc aagcacctag taattctaaa atgcgtggtt 67020taggtgagct ttatatgaaa gcaggtaaag agtcaggact tgacccaagg tacttagtgg 67080cacatagtgc tgttgagaca ggctggggaa cctcgaacct ttccaaaggt ggagacccta 67140acaaaggtaa ttggttcggt ataggtgctt ttgataacaa tcctaataat ggttttaact 67200atggattagg tattgttggt ggtgctaaat ggattagaga taacttctac aacaaaggac 67260aaaagaactt acatgatatg agacataaca atggtgttca tgagtatgca acagcaggta 67320attgggatac tatgattgcc agtattatga aaggttcaga caagttcata ggtggtggag 67380gtggaggcag tgatgttatg cctagacatg ctctaaaaaa tgaccatcaa ccaaagaatc 67440ttaaatataa catagaagta cctaaaagta aaaaccctaa tgaaacaggg aaagcaatag 67500gtagaaaatt aaaacaatta ttagaatcta atttttagaa tacaattata atatttatat 67560actttaacaa agggtacaaa caataaaaaa cagaaaatgt ctacagaaca actaagagaa 67620aagaataata aatcagaaac taaaaactta aaaacttaca gtaacctatt agatagggca 67680caacaaatta tagaagatgc taaagcgcta gactcaggag gttcagacag tagttctgat 67740tcaggaggtt cagcttccga tgtagatgga gaaggtgcgg gtaagattta caaattcctt 67800aaaggtaaag gtttatccga taaccaagta ggtgccgtta tgggtaacct taagcaagaa 67860tcagggcttg accctaatgc aaagaacgcc tctagcggtg cttttggtat tgcacaatgg 67920ttaggtagta ggaaatcaga ccttgatagc tttgctaaat ctaaaggtaa gaagtctaat 67980gacctagacg cacaattaga tttcttatgg aaagaaatga gttctggtca aaacagtgat 68040atgcttaaaa atgcaggatg gagtaaaagt ggaagcttag aaagaaatac aaaagctttt 68100gcacaaggtt ttgagcgtat gggtgctgga gaagctatga tgagtaccag agttaacaat 68160gccaaaagct atgttagtaa atacggtaag tcaggtggtg gcggtggcgg agttatacca 68220tcgtcatata cttcagtcat gagaaatcct atacttagta gtacatctgg aagtagtaaa 68280tctcaaaaca atgtttctgt gagtgttaac atcacaggag taaacgataa agaagatgcg 68340gaaggcataa gcaaaggtat taagtctacc tttggtgacg atttagacat cttctcaaac 68400acgtataaac gtaattatta gggtagtatt attaagtact accctttata taaaaataaa 68460ggaagtacat atatgtatag aattagacga cctaagatac gaatagaaat agtaacagat 68520gataatacat ttacattaaa gtttgaagat actaaagatt acaacggcaa tcaatttgct 68580tcaaagttac ttagttttca aactaagaat gctatggaag atgatagtgc tgtattccaa 68640ataactatgt caggggatac gtattgggat aagctagtaa tggcaaatga tattattaag 68700atatatatta cgcctaataa tgaccctaaa gataaagagg gaaaccaaga gaaacttata 68760caagtgggta tggtatctca agtatctaaa gtaggtagtt atggcaatga ccaagtacaa 68820tttagaataa caggtcaatc atttgtaaaa ccttttatga agtttggttt aggtgttata 68880caagaagtac aagctgtatt accaactgtt ggttggttag ttgatggcga tggagagaat 68940caggttaaat ttacaggtag ttccgctaaa gatgtaatgc aaggtattat acaacgattt 69000attccttaca tgaagtacaa ttatacggat aaaacataca acacattaga gagttactta 69060gattatgatg atttatctag ttgggatgag tatgaaaagt taactgaagt ttccgctttt 69120actaactttg atggtacatt aaaacagcta atggacttag taactgctag accttttaat 69180gagttattct ttagaaattc agataaacat aaaggtaaag cacagctagt attaagaaaa 69240actcctttta atccaactga atggaaagca ttagaatata tagttgtacc aactgatgat 69300tttatagagg aggatgtagg taagagtgat gtagaaacct actctatctt tacagtaaaa 69360ccagcaggta tgttaaaaga attaacaggg gatgtattct ctaaaccaca attccaccaa 69420gaattagtag atagatacgg gtattctaaa tatgaaacag aaaacctata tataggaact 69480aaaagtggta gtgctacaga agatagtgaa actacaggtg gagataatgg acacgaacga 69540gtaacttatg acagactact taaagattta aataactatg gtagagagtc tatatctaaa 69600ggattagata aatactctag taagatatca tcaaaataca acaatattac taaacctgaa 69660gtaaagagta ttttagaatc ttatataaaa aaaggtaatc taagtaagga agaatatgaa 69720aaaataacaa agaacaatac ttcaagagag tcagtatctg atactagacc aaaactaaca 69780aaagaaaaat taaagtctat attagcggaa aagtttaata agaaagaaac ttttgatgat 69840aaagatttaa ataagaaaac aacaaaagct gtaatagatg atattacaaa gaattataag 69900tatggtaatc ctacacatgc taagaaacta ctagagtatt acactagatt taaaggcaac 69960ccaccgacaa gtaccacagg tgatatttat gataagtatc ttaaagccgt agaaggagta 70020gctaatgttg ctagagatac aggttctgac gcaagtgatg actctttaat tatatttact 70080aaaatgctat ttaattggta tcactcaaac cctaattttt atgcaggtaa tattgttgta 70140ttaggtgacc ctaagtatga cctaggtaaa cggttattta taaaagataa acaacgaggg 70200gatatatggg agttttacat agagtccgta gaacataagt ttgattataa acaaggatac 70260tttactacaa taggagtaac aagaggacta aaagatgcta ttataaaaga tggtgaagga 70320agcaaacata ggtttaaagg actatggaat cagtcatctg actttatggg tggtcttatg 70380ggtgaagaga catctaaaga attaaaagaa aaaggtgtag ccgagaagaa aataaaagga 70440aataaagatg gagactccga aggtggtgca caagatggag gcactttagc ttcattagaa 70500aaatataatg gtaaattacc taaacatgac cctaactttg ttcaaccagg caataggcat 70560tataagtacc aatgtacatg gtatgcctat aatagacgtg gtgagttagg tattcctgtt 70620ccgttatggg gagacgcggc ggattggatt ggtggtgcta aaagtgctgg ttatagtgta 70680ggtagaacac ctaaacaagg agcttgtgtc atatggcaga gaggcgctcc tggcggaagc 70740ccgcagtatg gacatgttgc ttttgtagaa aaagtattag acggtggagc cagtatattt 70800atatcagaac ataactttgc aactcctaac ggttacggta caagaacaat agatatgagt 70860tcagcaatag gtaaaggtgc tcaatttata tatgataaag gataattgat atggcaacgg 70920ataaacaagt taaagatgtt atagataaat ttatagataa tcttttcaat tttgaagtat 70980taaccaaaga aaaggttgaa gaaaaagata aggaagttaa aaagataact acagaagacg 71040tatacaataa agttgtttat attagaccat atgtaggtgt tatacaaagt gtaacaccta 71100gacaggtaac atatgatagt tttactaata atggtacaga tatagaagct aaactcacat 71160ttagaaaaat aagttatact actgataatc tcacagtacc tactgatgca ttatcaactt 71220gtatggtgca tatggtagaa agaaatggtg tacttgttat agattacttt gatgagttac 71280agaacatact gtatggtagc tacatggaga atgagcatat atttgatgaa gatgttccag 71340ttagtacatt agtaacatta gacttgaaag agaatttaaa taattataaa catatacagt 71400atatgtttaa agggaatacg gataaaaacc cttttgaaag taaggatata gtacctttag 71460atacatacaa cttattatat tggatgtata aaaagagaaa tgtagagctt aaaaatccat 71520taacagttaa ctacttcttc acaggtaaaa gcttctatac tatatttggt aagggacaca 71580aatataaagt tgatattgac aaattcaaaa taggtgatat actattcttt ggacgtagtg 71640atgataatat agggatatac ataggagata agaagtttat ttctcttata ggtacatttc 71700ctaaagataa cacctctatt agtacctatg agttagacga ttattgggat gactttaatg 71760gtagggttat gaggtttgat gaggatgata taacatggtg gtaagattac agtcttcttt 71820aggtagaagt ttaaaaaaga tagactctga agaacttaat gttaagggtc tattattagg 71880tacagtaagc aaaataaatt ataagtacca aactgtagaa gttaaaataa atagtttaac 71940actaggacgt aaccctagtg atgacggtaa gttagctgtt ccttatccta aagattatgt 72000agggagaaca cctgaaggta gtatttatgg tagtaatact ttaataacgg aaggaactac 72060tgtactgtta ggatttatta atgatgacat taatcatcct attatactat ctatctatgg 72120taatacagaa gtaaatcagc tcataaatac caatccttta gaaggaggta aaatgaggaa 72180tgacgacgtg tataaataca gtagtgcttt atactctata ttacctgacc taacttatac 72240atataaagat ggtgaaggaa catccattaa aacatttaat ggtaaatctt tcttatctat 72300tacttcggga gataaagaaa aaccattagc gtcagacttt tatacaggca ctgaatatca 72360agacctattc ccatcatatt atagtaacaa aaatttaata gaacctagaa tacaaaaggc 72420acctaacatg ctatttaaac accaaggact atactttgat gatggttctg aagacaatca 72480tgttacaact ttatttatat ccgaaaaagg tgatgtgaga gcttcagtat tagacaaaag 72540tacacaaaaa agaacaacac aagagatgtc tcgtgatggt tcttatagag ttgtaaaaca 72600agatgatgac ctattattag actcagcaca agtatgggta gagtttggta taaatgataa 72660taatgtgttt tatataaaaa accctaagca tatgtttgaa tttaatgata aaggtatata 72720tttagatgat aagccaattt tagatacgtt agatgctagt attacagagt ctatagatag 72780acttaaggaa gtacagaaag aattagatga cattaactac ttacttgagg gtgtaggtaa 72840agaaaactta gaggagttaa tccaagagac taaaaaatct atagaagttt ctagtaaagc 72900aagtagcgat gttacgacta tgaaatctca aatatccaat gtaagtagta gagctgaggg 72960cattattaca cagtttcaag agtttagaga caaaacattt aaaggcttat atgaagatgc 73020ttctactatg ataaataaat acaaccaaga aatacctgag ttaaaaagta gattgaatac 73080tctagataca attacattac ctaacattaa taatacctta ttagagaaat caagtaagac 73140ctatgttaat aatagttctc aaagttttag tagtaattat ctaggttcat tactgcaact 73200agatagtaac cttactattt atccatacac acctacacgt attacatgga ataagatagt 73260ttttaataat tctgagtttg taaataagac taaggatgct tttgttattc cattaggtgt 73320atctaaagtt aaagtttcta ttaatcttaa atgggatata ttacaagata aagtaaaaac 73380tattacagtc aagaagaata gtaatacata caaaactata actaatggta atacacacga 73440taatataatt acaaatgtta tacctgttaa acaaggagat acattcacag tagaagtaca 73500acaagataat gatattaacc ttacattact acaagatgat acaatgttta gtatagaagt 73560attagaaact actttagcac ctactaatac tgagttatta ggtacagtat ccgaacaaac 73620agataagcaa ctacaaacac ttgtaaattc taatgttgat ttactaagtt taacaacaca 73680agttactaaa gataatcagt tagtttgtct taatgattcc aaattagaca atataacaac 73740aggtaaaggt aatgtatctg actatactct acaacaaata aagtcatttt cagctaagaa 73800tggtgagagt attttatctt tagaagatgt attagctaaa tataaaaatt atattagata 73860tagtattaat ttaccaacta ctgcaaacat agtagaacta ctgaaaaaat ataatttaat 73920tggtataaga gcacctagga atcaggtgta tttgaaagtt aaagatttaa caatcacaca 73980agaagtatta aataattttt ctaacttacc agtattatat aatacttcct atctaacaag 74040tacagatatt aacaaaggta tatatacaaa tatatatgga gtactactac catatactaa 74100tatcactcaa gatacagtaa atacagcaca taataataac ctatctatat atgctagtgg 74160tgatatgaca agtgatatta taaataagct tattttatat ggtatagatg gtgtagaaac 74220aaataaaata ttagagttta aaaaagttta aaagtcctat taatagggct tttttatata 74280tgtcatgtta tattaaactt gagaaagtag ttgtatttaa atcctatata tgatataata 74340cgatatagaa aggtggtaag ttatgcctca atcagatgga aagaatacaa taagacgtat 74400tgcattacgt tttccaacag caagcggtaa atataatatg taccgtttca aagtaaaccc 74460tgaaagttat gaaatagatg caccacaaag aacatctata actaaaacta aatcagacat 74520tattgttgaa gattacggta aagatataga gacaataact ttttctggta ctactggatt 74580tagacctgta aaagaagtag atggtactaa aacaggaaaa caaaaaatag aggaactaca 74640agaacaagta gaagcatacg ctaagcaggg tggagatggt agcgtagcag gagcttatat 74700agagttctat aactttactg atgataaata ctacaaagta catttagcac cgcaaggttt 74760aaaaataaca aggtctaaag atgaatcctt gttatataga tacgaaataa ctttagttgt 74820tataggtaac cttgctgaag cagacagagg ttccgtaaca tctgctgagt ttggtaatgt 74880aaaacctaat gctaaacaaa gagttgatga gggtgttaat gatttagata gtaacgcacg 74940aaaaacaaga aacaagaata atcaaatagt atcacaattt gaaaataaaa gtagtaaaag 75000ctcttctaat tctagtagta gtggttcacg atatggaacg gcaggaacat taagaggagg 75060tagtggcata agaacaggtg gttctgaagg taatagagac ggtatgagta atataggtat 75120atataaccct agacagaata ctaacggtct tagtagtact gttgatgata tggcacttaa 75180aataggatac ggtgatggag gtgtatctag gtaatgaata attatatacc tcaaccacaa 75240ggactattaa ggtttttaaa tggattagag ttagacatgt cttacacaca tataaactta 75300ttagatgagg aagtaccttt tgtttctaaa ttttatacac cacaaataca actaagtgaa 75360cttgcaagag taaaattaaa agagattaag tctactgata tccctacttt agaaagaaca 75420tttaacaaca atacaatagt taataaagta gaacaaacaa gtttaaagtt acaatcacct 75480agaatgtatt taattatgca atctatcgta atggaagctt acgctattgt aaactgcttt 75540gtagaaagtc ctgaatactt aaaatattta acagaaaaag atgtatctat agtgagaagt 75600aatgttaact atgtagctga ctacttaagt gattatgaag aatacaatag tattgttctc 75660gatttaagag acttagactt atgttttggc tctttggaat tacaactacc gctaattaag 75720agtgaggtgg tataatgaga tttagaaagc atgaagtcca accagaagaa accttacaag 75780ctatatcaca aaggtattat ggtgatgtta gttattggtt agatttaata gaacataaca 75840acttacaata tccttatatt gtagatacag atgaagaaaa gaaaaggaac cctgaacact 75900taataactaa gggtgatatt attattatac ctttagatgc tgagttaaca gactcggttt 75960ctaaagaaat aacatcaaga gataaagatg tattagtaga attagcttta ggtagagacc 76020taaatatgac ggataataaa gagtatatag acgctcatgg aacagatgat gaaatattag 76080ccctatcttc agatggtaga ggagaccttg atatagttaa aggcatagat aacattaagc 76140aatctttaag agctagacta ttgacaccta aaggttcttt attattacat cctgaatatg 76200gttctaacat tcataattta tttggtttaa atatacctga acaagctacg ttaattgaag 76260tagatgtatt aaagactcta acatcagata gtagagttaa atcagctaac ttaaaaggtt 76320gggagataaa aggtaatgaa tactatgggt catttaatgt agaaataaag tccgtagaag 76380aatctataga ctttgtatta ggtcaagatg attcaggtgt ctttgcttta tttgactaag 76440aaaggaaatt tatatgagaa caagaaagtt aacacagata ttatctaggt taatagataa 76500gacgatacaa ggtacaagca aaataacaga ctttacacct ggttcagctg tacgctctct 76560tttagaagca gtagctttag aaatagaaca gtattatata ttaacaagag aaaacattaa 76620ttggggcatt caagaaggga ttattgaagc ttttgatttt caaaaaagaa aagctaagcg 76680tgcttatggt aatgtaaaca ttcaatttta ccaaccttta gacatgagaa tgtatatacc 76740tgcaggtact acattctcat ctactaggca agaataccct caacagtttg aaacattagt 76800tgattactat gctgaagaag gaaccactga aattacagta gaagtttatt gtaaagaagt 76860tggtattgta ggtaatatac ctgaagatat cattaataca atagcctcag gctctagttt 76920aattcgtaca attacaaacc cgacttcctt taatacagga acaaaagaag aatctcaaga 76980ggattttaaa cgtaggttcc atatgtttgt agaatcgaga ggaagagcta ctaataaatc 77040tattagatat ggtacattac aagtacctga tgttgatggt gtttatgttt atgaagaagt 77100aggtcatgtt actgtatatg cgcatgataa aaacggaaat ttatctgcta ctctaaaaaa 77160tgacataata acggcattag aagattacag acctagtggt ataaagttag atgttgtagg 77220tgtagagaaa gaggaaatag atgtgtctgc agtagtaaca atatctaata aagctaggat 77280aggtgataca ttacaaagac atattgaaag tgttatcaga gggtatctaa atagtctgac 77340tacttctgat gatttaatta ttaacgattt aattcaagct attatgaata tagatgataa 77400tttaatttat gatgtagcat ttaagaattt atctacaaat atagaagtat cttcgaaagg 77460tattattaga gcaggggata ttaaggtaga attaatatag ggggtaaaca atggctaatt 77520ttttaagaaa tttacaccct ttattaagaa gaaataagaa taataaagat aaccaagacc 77580ctaactatgc tttaataaca gcacttaatg atgagatgaa caatatagag ttagacacca 77640ttaaaagcaa acttcaatca tcattaaaaa ctgccacagg agattactta gataagtttg 77700gggattggtt tggtgtatac agaagaataa atgagaatga tgacagctat agaaaaagaa 77760ttataaaata cttattatta aagagaggta ctaataatgc tatcattagt gctattaaag 77820attacttaga taatgagaat ataaatgtta gtgtatatga accttttaaa aatatattct 77880ataccaataa atcaaaatta aatggtgaag attatttaat gggttattat tatagatttg 77940ctgtgataaa tgtttctgtt gatggttact ttcctttaga gattatagat gtaataaatg 78000aatttaaacc cgcaggtgtt aagttatatt taacttatga tggtgctact accataaagg 78060gtgatggtgt tgttaaatgg cttaaaaatc tacctaaaat tgaaacatat acggatttag 78120atagattatt aggttatgat gaaactttct atgggcattt aaacatgagt gaagcaacag 78180ctgaacaatt tgataaaaca aggttcagaa caaataagag tatattaaat agtgaagata 78240ttctatcagg ctcttctaat attggacgta gatttataaa ttatgcttat gttacgacat 78300atgcatatga acctactagt acatcagccg tcacacatat agcttcttta aatgataaag 78360gaaaagaagc acctttagat tattacttat acacatcctt aaagaatact aatggtataa 78420atatatcaat ggaaactgct tatggtgtat cttatttata caataacttt aatgtaagtg 78480agtttatcag cagatacaaa ccgaatatag atataactag agataatgct aaaaaacaaa 78540tatccgattt tataggagaa ctaacaattg atttctttgc aaaagcttta gtttcacctg 78600atgaatcatt acctattaag ttacaaatat ttgattttcg tactaatgaa tggttaactg 78660tatcagaaac agaactatct ttttacgaga aaaacatagg tgtaaacata ggttatataa 78720gagattactt aaatgatgac cttaatttat ttacaagatt agaggttaat ataggtaaag 78780atgagcaaaa agatataagt attaactaca tggatttaca tttttataat tataaaaaag 78840atgtgtatac tatcaaacct tttaaggcac tagttgaaaa ctacatagat ttgactaaag 78900atacttatat tgaaggcttt aaagtagcct cattattaaa tggagacata attaataaaa 78960atggatatca acccataaaa tatttaaggt tacatgctac ttatgattca actaaaccta 79020ttgtaagtat tacaggtaaa aacagcaata atgaggtaca aaataataca cctatagatt 79080tatataaaaa tacaactaat agaaacttat tgcaatcata taaaggtgat agtaatatat 79140tcaagggtgt tgtaagcaca aaagagtttt atatctcatc atgggctgac accttatata 79200attcaacgta tttatctaaa gtactagaac cacaaaaatt atatactttg tcattcgaga 79260tggaaatcac agatgctaat atggacttaa aaacatattc tgacaatcat ggtatatatt 79320tatatagtag tactaaaggt attgttgcta atggtgttaa aagcatgcaa agaaaaatag 79380gtaataagat tgaggtatct atcacattta cagcacctac aattacagac catagacttg 79440ttgtttacac aggtagatat acagcagacg gtactgcttc taaaacacct attgcttata 79500atacggtaaa agtaacaaac cttcaattaa aagaaggagc tactaagaag gactacacgg 79560tagcacctga agatgtaact aatgttatag acaaagctat tgtgtttgat aacatattaa 79620cagatataca aacaatagga ataaatacaa caacacctct taaaaatatt gagctaagtt 79680attcttacta tggggataat tggacaagcc taaaaacaat aagtaattta agtcaaggtg 79740aaacaataac acctaataac ttagtagatt tatatgtctt agaaacaata gattattcaa 79800gtattacacc tttctctagg gttatactta aaactatatg gaatgctaac ctgaataatt 79860taacaaataa aaaaggtagt atttctaaca tgagtaataa ctatttcaat gctgtgtggc 79920aagaggtaga tatgatatat aacactacat taagtagcat gagcatactt actgatagtg 79980aaggtaatgt atttgatagt tcaacaggac aggtaataaa attagcacct aagatatacc 80040aaggatatac tgatgtagat agattgctaa cgtctactac tctatataac gagaatatta 80100cattaggttc aaatagattt atttatgact tacgggatat gttactatca agtgatacat 80160tcacagtaga taatagaatt aaagtaatag atacgtacac agaagtacag taaagatatt 80220gacaataaag tattaatatg atatagtaag gtatgcgtat tatagtatac cttgttatat 80280taatacagaa tactagacat gaaaggaata aaaaatatgg ctatagcaac aaatgcttca 80340catgtagaat tagctaaata cattgtaagt aaggctgatt ctatttattt aacaattggt 80400aaaagtacag cgtgggctaa tgaaacaaga ccacctcaac ctgaagaaac agcaacatca 80460ttacaagaag ttatcggata taaaaaagca actaaggtag cattagttag acctgcaaaa 80520acaacgggtg atgaaagtaa aaaagaaatt acatatggta ataaacgatg ggtagaaatt 80580gactcagcta atgcagttgc tgaaggtgct aagtgggtgt acttagaaag tagtattgtt 80640ggggatgagt tacccttagg tacatataga caagtaggat ttgttatgga tttgttagct 80700aaagatagta tttctaaatt taacttacta cctagtgaag tgcaatctac aggaacttta 80760ttattttatg ataataaaca gttccaaaat agaagtgaac aaacaactgt aaaagagcgc 80820tttatcattg aagtttaaaa aggagaattg aatatatatg gcaattaatt ttaaaagttc 80880tccatactta gatagatttg accctacaaa agatagaaca agagtactat ttaatccaga 80940tagaccacta caacaatcag aactaaatga aatgcagtct attgaacaat attacttaaa 81000aaatttaggg gattctattt ttaaagatgg ggataaacaa tcaggattag gttttacatt 81060aactaaagat aatgtactac aagttaaccc aggttatgtg tatataaatg gtaagatacg 81120ttactatagt agtgaagaca ctgttaaaat tacgggtgta ggtaaagaaa cagtaggtat 81180taaactaaca gaaagaatta ttacacctga tgaagataat agcttattag accaaacaag 81240cggagttcct agttattttt ctaagggtgc agaccgtcta gaagagaagt tatctttaac 81300agtcaatgac cctacttctg ctactattta tacttttatg gatggagacc tctatatcca 81360atctactaat gctgagatgg ataaaatcaa caaagtatta gcagagcgta cttatgatga 81420gtcgggttca tataaagtta gtggatttga gctattttca gaaggaaacg ccgaagatga 81480taatcatgta tctgttgttg tagatgctgg taaggcatat gtaaaaggtt ataaagtaga

81540taaaccagtt tctaccagaa ttagtgtaga gaagtcaagg gaattaggta aagcagagaa 81600tgaaagtact gtatttaata aatcatcaaa taatattact ttagctaata cccctgtaaa 81660agatgttcaa cgtgtaacag cgcaagtatt agtagataaa gagcgtgtta caagaagttc 81720aacaggagat tctcaagact atttatctaa taaaacagct tttgaagtag ttagagtatg 81780gacagaaaca agtccaggtc agacaacaaa agaatataaa caaggagaag actatagact 81840tactgatggt caaacaatag attggtctcc ttcaggtcaa gaacctaatg gaggtacatc 81900ttattatgtt tcgtataaat acaacagaaa gatggaagta ggaaaagact atgaagtaac 81960tactactggt gaaggtgtag gtaaacgctg gtctattaac tttacgcccg ttaatggtac 82020taaacctatt gaccaaagtg ttgttcttgt agactatact tattacttag cacgaaaaga 82080tgctgtattt attaataagt ttggtgatat agctatcctt aaaggtgaac ctaatattat 82140gagattagta acaccacctc taaacacaga ccctgagaat ttgcagttag gtacagtaac 82200agtattgcct gattctaacg aagcagtatg tatttcatat gctattacta gattatctat 82260ggaagaccta caaaaagtaa aaactagggt agataactta gagtataacc aagctgttaa 82320tgctttggat gatggtgcaa tggagaaaca aaacccatta acattacgtt ctgtatttag 82380tgaaggtttt atatctttag ataaagccga cattacacac cctgactttg gtattgtatt 82440tagttttgat gatgcagagg ctactttagc gtataaagaa gctgtaaatc aacctaagat 82500tatccaagga gacactacag ctcatatatg gggtcgatta atttctgctc catttacaga 82560agaacgtaca atttaccaag ggcaagcatc agaaacctta aatgtaaacc catacaacat 82620accaaataaa caaggtgtat taaaattaac tcctagtgaa gataactgga tagatactca 82680gaatgtaaca atcacagaac agaaaactaa aaaagtaaca atgaaaagat tctggagaca 82740taatgaaagt tattatggag aaacagaaca ttacttatat tctaacttac agctagataa 82800aggacaagag tggaaaggta agtcatacgc atatgataga gaacatggta gaacaggtac 82860tctattagag gctggaggac agcgtacact tgaagaaatg attgaattta ttcgtgttcg 82920tgacgtatct ttcgaagtta atggtttaaa tcctaatgat aataatttgt atattttatt 82980tgatggtgtt cgttgtgcta ttacaccaga aacaggctat agaaaaggtt ctgaagatgg 83040tacaattatg tctgatgcta aaggcacagc taaaggtaaa tttacaattc cagcaggtat 83100tcgttgtggt aatagagaag taacattgaa aaatgctaac tctacaagtg ctacaacata 83160tacagctcaa ggacgtaaga agactgtaca agatgttatt atcaaaacac gtgttacagt 83220aaacttagta gacccattag cacaatcatt ccaatatgat gaaagtagaa ctattagttc 83280tttaggttta tactttgcta gtaaaggaga taagtctagt aatgttacaa ttcaaattag 83340aggaatgggg gacacaggat accctaacaa aacagtttat gctgagacag taatcaatgc 83400agatgatatt aaagtatcta ataatgcaag tgctgagaca cgtgtttact ttgatgaccc 83460tatgatggct gaagctggta aagaatatgc tattgttatt attactgaaa atagtgatta 83520tactatgtgg gtaggaacaa gaacaaagcc taaaatagat aaaccaaatg aagttattag 83580tggtaatcca tatgtacagg gtgtattatt tagttcttca aacgctagta catggacacc 83640acaccaaaat tcagatttga aatttggtat atacacatct aagtttaatg aaacagctac 83700aattgagttt gaacctatta aaaatgtatc agcagacaga ttagttttaa tgtctacata 83760tttaacacct gaaagaacag gttgtacttg ggaaattaag atgattttag atgatatggc 83820aacatctact acatttgacc agttaaaatg ggagcctatt ggtaactatc aagacttaga 83880agtattagga gtagctaagc aagttaaact aaaagctaca tttgagtcta ataagtatat 83940ttcaccttta ttaagttcta atgacttgac ttttactaca ttcttaactg agttaaaagg 84000ttcatacatc ggtagagcta ttgatatgac ggaagcacca tataatacaa ttagatttag 84060ttatgaagca tttttaccta aaggtacaaa tgttattcct aaatactcag atgatgatgg 84120tagaacttgg aaaacattta ctacatctgc tcaagtagtt aaggctaata gagactttaa 84180cagatatgtt attgatgaga aagtaaataa atctactaag aatagtaaat tacaagtaag 84240attagactta tcaactgaaa acagcttctt aagacctcga gtacgtagac ttatggttac 84300aacaagagat gagtaagttt aaagagggtt taataccctc tttttattta attaaggaag 84360tgatatcatg cctacagaat acagagaccc ttattcacaa gcaaaactct ttattcctac 84420tgtagaagag aaggctataa aagaaatgga acaaacatat aaaaataaat tacaagaagt 84480tgatgagctt atcaatgaac ttaaaaaatt gaaaggtgat tatacacatg gcgtttaact 84540acacaccctt aacagaatca caaagattaa aagatatgta ccctaaagta aatgagatgg 84600gtagatattt acaagaagaa gttaatctag cggatgtaaa aacaataagc taccctgact 84660taagtaatat tctaacttac atacaagagt caggagatta ctttgttaca caagcaagaa 84720acacaccagg aggagtaagt aacacaggtt ttttacactt agataaaaaa ggagatactt 84780attataagtt atattatgct ccttctaata caaataaatt atttgtaaag acatactata 84840atggtacggt atatgattgg gttaacttta aattagatga aggtaaccta tatgatgcag 84900gtaatacaat taatgtaaaa tacttaaatg aatctactac gcagtttgct actttagtaa 84960atccacctaa aagcaacttg aatacagggt ggataaatta caaagagagt aagaatggta 85020tgtctgcttt agctgaattt aaccctatta actctacttc tacttttaaa atgattagaa 85080agttacctaa ccaagaccaa caacctaact tactgagaga tagtttgttt accttaccta 85140tggctgatat atctaatgta agaacggatt acatagataa tacatctttt tggggtttta 85200ccgataatgc ttctatatca acagttaagt atatgggtga aaatacggta cagttagatg 85260atggtaagga gacgtatcct acagttatgt caaaacgatt cagaatagga aacgaactat 85320atgtaggaga tactgttaca atgtctgtgt atcttaaagt aaatgaccct aatttgttaa 85380atggtaattt cccttacttt gagattgctg ggtatgatta tgtttatcaa gacaataatc 85440catatacagg aggtaggaga gaggttaact attatgattt atctacggag tggaaaaagt 85500tctcttttac ctttactata cagtcctata atcaagagta cggcaatgga agagttaatt 85560atatatcagc tttattaaga tttaactgtt ctaactctac taataatggt gcaattgtgt 85620attatgcact accgaaatta gaaaaatcat actcagtaac tccttttatt acaaatactt 85680atgataatag aaagtatgat gagatatgga gtaattggat tgaaacaaca agtaaagatg 85740agcttcaatc acatagtatt gtagacacat ctaataatga ttattacaag tatatgtgga 85800attaccaaaa cgcaaacggt aaaaatttac aacagttagc aatgtctgta cctcaaggtt 85860tttatacctt ttactgcgat ggttctataa gtggaactcc tagtaataaa acaatacaag 85920gtacaataca agtagcatat aaaaataata atataaacac tacaaataaa gtaatacaaa 85980tggattttaa tgacactaaa ggcaagaaat attctctaac ttataataaa gatgataatg 86040gttggcaaga catgaaagtt caaatggcta gtaacagtct ttgggaagga acgctcgacc 86100tatcttcagg aaatatagta aacttatcag attcgttaga taattatgat tttattgacg 86160tagtatattg gactagaagt tctggacata atgcaactag aagattccct gctactacat 86220ctagtattgt aattagagac tttaacctag taaatgatgg ctctaactct agtgtagatt 86280tctttgaagg gtattgtgat attactgata gggtaaacgt cactgctaaa atgtcaaaaa 86340cagttaacct agacggaaat agaaatacta catcagtagc acaattcaat caaacaggtc 86400acattgaagt actaagagta atagggttaa catatattta ataaaagggg ttttatagat 86460gataaagtat gatattggta aagatgaaat tgtattacat ttaaaagata ataaatatat 86520tatggggtac actattgtag gaggttataa tgagagcaat ggtgatgtaa aaatatcaag 86580gtctatttta cccgatggat tctttgctga ctttgttagt aataagtatg tgtactataa 86640gaacaccaac gaagtaatat ataataaaaa ctttgaagat aatacaaaga gtgtagaaaa 86700cacagaatac caaccgccag cagagtttgt acctaaagaa gattacaaaa aactagagag 86760tgaagtagaa gaactaaaaa gaatgttaca agaattgtta tctaagaaag gataaatagt 86820atggcactaa attttacacc tattacggaa aatagtacaa tagcagacct aacaaaacaa 86880gttaataata taggtggtgt attaactgag gatagaaata tcttcgaagt aactgcagac 86940ttacaattag atgtaagtag aacacagaaa gttaagttaa caacagataa agggttagct 87000aaagatatag actataccaa ttacttaaga gatattaaaa aagtaggttt atattacata 87060ggggcacgta cattagctac tatgtatgat aaaccagata tggaaaatat agatgtatta 87120ctgcaagtat taacactaga tactgaggat agagtaatac aaatattgta tacattatca 87180acggcggata gtaaatcaaa aatgatgcat cgattcgtta ctaactatca aacatcacaa 87240tggcaagtag tacaaagttt acctaataat aaatatacat ctcatatagg tggaagtcct 87300tttgatatta atacacaagg tacatattac gtgtctaata tgtcggatat gcctagtggt 87360gtttatgagg gattcttaca agtttctata gataataatg ataatagaat gttgagatta 87420acagatagta gtacaggaaa agaatatctt aatgttaaga aagagtatgg caattggggt 87480tcttggagaa ctgatttaga tgtacaaaag ataagcaaat atcttgtatc taatgtaaat 87540ggagatgcgg aaaacaataa ttactcatta tccgtatata cagcagataa tataacattc 87600caacaagcta tagctaaaca tatcgaagaa acaagtaaaa ctgtttttac tttttatgta 87660caaggaggtg ttgtagggtc tccatcttca gttagttgta gaggcgtatt catatcagat 87720tcaactaact ttactaatct atatggtgtt tatactgcta taggtactga tggcagaacg 87780attaatggtt ctgtaaatgg taacacatgg aatgtagcaa aaacattacc tggatttaaa 87840gagctgtgga atggtgcaca taactttaaa gatacaaata aaaaagaaac catgtctgat 87900tctatatcta actaccagta tgtagaagta tacacaagat acagagcctt acaaaacaca 87960aaaggtacgg ataaaacagg tactttatgt cataagtttt atgtagatgg agatggtatt 88020tacacatgtt caggttcata tgtatcaggt gactctaata ttggagtaga gtactatcga 88080gtaactttat ctattactgg tgatacatgg acagttaaag atagtgcagt aaataataat 88140aaagaccaat atgttacacg tgttgtaggt atctctttac catagactag gataattcct 88200agtctttttt ttttcttgac taactttaat aaatatggta agataataaa ggactaaaaa 88260gaaaggagaa tatatgcagt taagacaaca gaatatatat acatatgtag attttgatga 88320aagtgacggg tatattaaag atatcatact taagcgtgtt cataaaacgt taggagctaa 88380gaaagatggc tatcaacata gcttagcttt taaacgaggt gtgtgggatg gttatgtaga 88440tttctatgat tatgctgaga acaaattccc tagtgggtta ttacctaaga tgataacatt 88500actaggtgag ttacaatcaa gacataactt tcaatacgaa attattgatg aaaaatctga 88560aagcttttta gctgaagaag atattgatga tgaaatacag ctactagata ataacgtagg 88620taagattaca ttacgtgact accagtatga agcggtgttt aatagtttag tcaattataa 88680tggtatatgt aagcaagcta ccaatgcagg taaattttgc cccttatagt agaaatatta 88740taagtgtaac tcctttaatt cacggaaact ctctcatttg agacaatcat gagccaagct 88800tagtaaatat caggaaggtg caacgactat tatgtacatc caagtggatg gaaacaggga 88860gaacctaagt ctcattagat atggttaaga tatagtctga actttgtagg tgactacaag 88920aaggttagga ataacgaacc taatcgtaac ataattgaaa acagaggttg ctagcggtat 88980catagaccaa ctattaccac aactagaaaa aggagagcgt gtggctttct ttacaagctc 89040taccgagatt tttaatcaat ctgctgaccg tttaagtgaa cgattgaata taccagtagg 89100taaagtaggt tctggtaagt ttgatgttaa acaagtaact gtagttatga ttcctactgt 89160taactctaac ttaaaagacc ctacagaagg agtgaaagta tctgctaaag taaacttaag 89220taaaaagata gctaaagaga tactccctaa atttgaaggt ggtaaaaatc aaaaaaggtt 89280acttaagtta ttattagaaa gtacgacacc taaaactaaa gtagagcaga atgtgcttga 89340tatactgcaa gatatttatc ataattcaaa gacggatgct gaagtattaa tggcattaaa 89400caatcataat gttattttcc aaaaagaagt aagaaagaaa aatcaaaaga gttatgacaa 89460gtatcataaa atgcgtgaat ttctagactc tatagctgta atgatagttg atgaagctca 89520ccactctaaa tctgattcgt ggtatacaag tttaatgtcc tgtgagaatg cactatatag 89580aatagcacta acaggctcca tagacatgaa agatgagcta ctatggatgc gtatgcaagc 89640attattcgga gatattattg taagaacatc taatgagttt ttaatcgaga atggctattc 89700agctagacct acaataaata ttattcctgt tgctaatcct gatgatatag ataatattaa 89760agattataga gatgcatata ataaaggtat tgtacagaat gagtttagaa ataaacttat 89820tgcaaaacta acagctaagt ggtatagtca agataaagct acgcttatta ttattaattt 89880tgtcgagcat ggtgaaatat tatccaatat gttgaatgat atgggcgtag agaatttctt 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91620aagtaaacaa gatattgtaa atatagaaca aacaacaatg aattatctac atatgagaag 91680atttacttca acatcatata ttctacaaat gtatagtaac tacttaggat atgaggttaa 91740tttaacagaa gttaagacta ttattgaaaa gtataattta tttgatgaaa taccattgac 91800aaaagaaggt atgatagaat acaataaggt tattgatata gtaaaggatg acacatatga 91860gtaaacgaat taaggagatt atcctacata aatctatgaa ggatatacat tttgcaagag 91920aagtactaga taagttacct aaaagtctat ttgctacaga atcggaagac atgggttact 91980tattcacagc tataaaaaga acagcacaca ttgctgataa aatgtcaaat gaatctttag 92040ctattaaagt agaacagtta atgggtaatg ataaacaaga tgacgagaaa gtaacacaaa 92100cattaaaata tttagatagt ttatatacag tagacatgaa taataaagac gattctgtaa 92160actatgaagt agaaaagtat attaaaacag aaatgtctaa agaagtatta gttaagttca 92220tagctgagaa taagcaagag gactcagata acttacccga attagtagag aaactaaaac 92280aaatagaagt tagtgacatt aatggtactg atggtgaatt tattgacttc tttgaagacg 92340tagataagaa gagggaacta ttaagtaact taagtattaa taaatattct acaggtttcc 92400attctataga ccaacaaatt gaaggtggta taggtagagg ggaagtagga ttagttattg 92460cacctacagg tagaggtaag tccttaatgg ctagtaattt aggtaaaaat tatgttaaac 92520aaggcttaaa tgttttatat attgcactag aggaaaagat ggacagaatg gtattaagag 92580cggaacaaca aatgataggt gtacaaaaga atcaattact taatggtgac ttatctttaa 92640acacagatgc ttataataag atacaagaac actataaaaa gaacagacag ctactaggta 92700atttttatat agttaagcat atgcctggtg aggtaacacc taaccagcta gaacaaatta 92760tagttaatac aacaattaag aaagataaac atatagatgt tgttattatt gactatccta 92820agcttatgcg taatccttac ctcaagtatc aaagtgaatc agatgcaggt ggtcgtattt 92880ttgaagatat tcgaaaatta tcacaagaat ataattttgt ttgttggact ttagcacaaa 92940caaacagaac agcttatggt tcagaaatta ttacaagtga acatgttgaa gggagtagaa 93000agattgtcaa tgctgtagag gttgcttttg ccgttaacca aaaagatgaa gaatttaaaa 93060atggtttctt aagattgtac ttagacaaag taagaaatag ttcaaacaca ggtgagagat 93120ttgttaatct taaagtagaa cctactaaaa tggttgttag agatgaaaca ccagaagagg 93180cagaagaaca taaacaaata ctagcagaac ttaacggtga agataaaagt agatttaaag 93240aaaaacctaa taaagctgaa gctattaata attcttttgg aggtattagt ttctaatgga 93300cgattttact aagctttata aaaaagtacg tagaacattt acacgtaata aagcagaatg 93360ggattataca aatacagggt taagaacttt ccaattaaaa ggaactaatg tatgtgttac 93420attactagat tctatagcaa ggaacaatac aacaggatat aagtataacg ttatgtcgaa 93480taaagtacct gctatacctt gcaatacaca tcaagaagta atcaaagcaa ttgaatataa 93540attaaaaaat tgagaaaaag ccttgacaat atgtttgtca gggcttatac ttttattata 93600aacaataaag aggtggtata ctttgaactt aaatgaagca aaagtaaaat tagaaaactt 93660taaagttatt aataaaaatg gatttataga aactgcgagc acaagatata ctgaaaaaaa 93720attagaagat gtttcaacta acatatttaa tacattaaat aattacgtaa cagataaata 93780tggttgtaaa ttgtttaata ttaaacctaa aaggagtatt atagagttag aattaacaaa 93840caataaaatt aaacacttaa gaaagtagga tattaatatg gaattagaat taaataaaat 93900atataacgaa gattgtttag aaggtatgaa aaagatacct gacaatagtg tagacttaat 93960tgttacagac cctccatatt taattaatta tagaaccaag cggagaaaaa ataaagaaca 94020tagatttgga aaagttattt taaacgataa taacgaacaa cttattatag attatataaa 94080tgagtgctac aggttactaa aaaacaatag tgccatgtat atgttttgct catcagacaa 94140agtagatttt tttaaacaac aattagagaa gaaatttaaa ataaaaaata tgattatata 94200ggtaaaaaac aatcatatag caggagattt aaaaggttct tttggtagaa aatacgaaat 94260cttattttta gtagtaaagg gcaaaaaaca ttttaatggg agaagattaa ctgatgtatg 94320ggaatttgat agggtaagtg gtaaaaaaca attacaccaa aatgaaaaac cattagattt 94380aataaaacaa tgtattatga agcatagtaa taaaggagat gtggttttag atgggtttat 94440tggtagtggc actactgcta ttgcttgcat gagtactaac cgcaattaca ttggttttga 94500attagacgaa gaatactata atttagccag tgaaagaata gaaaaacata aggagatact 94560aaacaatgaa aatgacaata caggaactac aagataagac tgaattttta agacatgtaa 94620aggtagatac ggaagaagca atggatatcc ttgaagatat attaagagga gagccttaca 94680cagatgaggt atgtgaattg atacattttt attcaagtaa gctactaaat gagattaatg 94740acaatcatat gtttaaatta caggagtttg ctaatcatga tgttatagaa attagtgaag 94800agggagtaaa ataatgataa aattattaca gggggattgc ttagagttat tagatacaat 94860tgaagatagt agtatcgatg ctattatcac agaccttcca tacaatattg caaaagaaaa 94920taggttcaca actatgggca gagctggtat tgattttggg gattgggata aaaattttga 94980aactacctta tggattaata aagctatacc aaaagttaaa aaagggggta atatcgttgt 95040gttttgtgac atgagacaat ttacacctat tattgatact atggaagcat taggctgtga 95100atttaaagat gttatacgta tggaaaaatc taatcctatg cctcgtaata gagatagacg 95160atttattttt gatactgaat ttgctcttta ttttgttaaa aaaggagcta aatggacttt 95220taaccgttta gatggaaaat atgaaagacc ttgcattaaa acaagtgtta cccctagaag 95280tgaaaaatta ggtaaaggac acccgacaca gaagccttta tatgctatgg agtggttgtt 95340agagcgttta actaatgaag gagatattat tctagactgc ttcatgggaa gtggaacaac 95400aggtgtcgca tgtaaaaatt taaataggga ttttattggt tgtgaactat caaaagaata 95460tttcagtatg gcacaagaca gattattaag tactacaaat taaaacaaaa cccttgacaa 95520catgtttgtt aggggttata attttgttat aacgtactaa aggagggtac taatgaaatt 95580tatatttttt acagatagtc attttcatat gtttacaaat tatagtaaac ctgatgaaga 95640atatggtaat gatagattta aagaacaaat tgagacatta caaaaagtat ttgatttagc 95700tagagaaaac aaagctaaag ttatctttgg aggagactta ttccataaaa gaaacgcagt 95760agacacaaga gtatataata aggtatttga aacctttgct aagaatcaag atgttaaagt 95820atatatggtt agaggaaatc acgatgctgt gtctaattct ttatatacgg aatccagtat 95880tgatatattt gaaacattac ctaatgtgga agtaactaaa gatttacgta gtgactcact 95940ttctagtaaa gtacaattaa ctatgtgtgc ttacggagat gaaacagaag aaatcaaaga 96000gtatattaaa aaatcttatc aaaaagataa agtaaatata ttagtagcac atttaggcgt 96060agagaatagt ttaacaggta aaggctctca cagattagaa ggtgcgtttg gctatcaaga 96120cctattacca gaacaatatg attttattct tcttggacat taccatagac gccaatactt 96180aaacaataat cctaaacata tgtatggtgg ttctctaatg caacaatcct tttcagatga 96240acaagaagct aacggtgtgc atttaataga tatagataag ctaacatcaa cgttcattcc 96300attagatact agaaagttta ttacagtaca aggtgacaat gtaccagata acatgaatga 96360tttagtaaac aagggtcact ttattaggtt tattggtact ccagaacaag ctaaagtaat 96420tgaattagat aaaacagaag atgaatctaa tgtacaagta caaatgaaga aagaatacac 96480ggtagaaaag agagtcgacg ctgacgtgtc tgacagccct ataacgatta cttctagtta 96540tgcagacaaa tattatccag aagcaaaaga tgagcttcta gagtgtttaa aggcggtgct

96600gtagtatgat agatattatt ataaagaata ttaaaccaag tatagataaa tctaaaccta 96660ttttacagtt cttacataat aaaagaacat atgatgtatg taatgttaaa aatattgatg 96720atgcgatgta ccttattaac aaagtattag aggaagctaa ctacgctcat tattatacga 96780gggttattga acaagaagat tgttatattc tagattatgg ttcacatcaa tgtttcttta 96840aattgttaaa agaaggtggt acaaatggtt aagtttaatt atgtagagat gaataacttt 96900ttagctattg agcatatcaa gctaaatctg gataagcaag gtcttgtact tattgaaggt 96960attaataaaa caaatgatag ttttgaaagt aatggaacaa gtaaaacaag catgatatcc 97020tctataacat atgcactgtt cggaaagact gagaaaggtt taaaggcaga tgatgttgtt 97080aataagtata agaagaaaga cacctacgtt aagctttctt tcaacatagg taaagacgag 97140tatttaatcg aaagataccg taaacataaa gaaaacaaga ataaggttaa gctgttctgt 97200aataacaaag agataacagg ctctacaaat gatgttacgg atactcaaat acaagagtta 97260tttggtattc cttttaatac atatgtaaat gctattatat atggtcaagg agacattcca 97320atgttttcac aagctaccga caaaggtaaa aaagaaatat tagaatctat tactaagact 97380gatatttata aacaagccca agaagtagct aaagaaaaag ttaaagaagt agaagagaaa 97440caaagtaaag aacaacaaga aatagaaaaa ctagaatata aaagaaacct aaaacaagaa 97500caatataata atgaagtaaa taaatataat aacttattag agcgtaagaa gcaagaagag 97560gaacagttta atcaaaagaa gcaagaatat gaggataaat taaaagattt agataatcaa 97620atcagtgaat ataagaatga tattcctagt attgaatctt ctgaatttgt atttagtgaa 97680agctatacaa aagccaagca aggtatcgaa aagattaata caaatatcaa tgataaactg 97740ttacctttac ttaaccaaga aacaacaaat aagaatacaa ctctaaatat gattaatcaa 97800ctaaaacaat ctattaataa attagataca aatgaccatt gtcctgtttg tggttcccct 97860atagataata cacacaaaat caaagaaaaa gaaaatttag agttacaaat tcaagatgag 97920caagctaaaa tagcacaata tgaacataat gagcaggcta tagttaacaa gaaagaagag 97980ttactagcta aatctaaaga attacaacaa tttatacaac aagaagatat agaaaagaaa 98040aaacatgatg atgacattca atggcaatat agagaacaac aagaggtgta taataagatt 98100agtcaattag aaaatactag agctaactta aaagaaccaa cattaaatga ttattcttat 98160atagaagaac ctaatgaaga attacacaat aaagaactaa aagatattga caatactatt 98220gacaaacata aggaaaatat agtacaatta gagagtaaga aaacaaaata taaacaagct 98280gtagatgcat ttagtaataa aggattacgt tctgtaatat tagactttat tacaccgttc 98340ttaaatgaga aagctaatga gtatttacaa atattagcgg gttcggatat cgaaattgaa 98400tttcaaacac aaatagaaaa tgctaaagga gaacttaaag ataagttcga tgttattgtt 98460aagaataaca atggagggga gtcttacaaa tctaattcag ctggggtaat gaaacagcta 98520ggaaataatt acaaaaatat ataaactgtt tgccctgctt atagagtaat ctgtaagtac 98580cagaggttaa atgctatgaa atcctaaagc tagttaaact gaaacataat ctgaaaagat 98640aaatggaaga gttacgaaag tagaaaaaat taactagatg tactaaggtt aaatcctaag 98700gtatagaaca atggaagtat agcagggaaa gtcctaaatg agcttatagc tcacatggaa 98760gaccctcaac gactattccg tataggtgac ggaagtaaag ccacaagtga ttggtggaag 98820aaaaatctct atcctagtaa aactaggaat aacaaatagt ctgcgcacgt aggaaaacct 98880agtgtctaga attaactaga gaatatacag tagcgtgtat atttaaacat tgttaaaatt 98940tataaataat taaattaaat tttatcctaa attcctgttg acatattcat ttctttatag 99000tatattagta ctataaggag gtgaaatgaa tgtcaaagga aaaagaaacg tacaaatatt 99060taaaattaag attagtacca acgaaagaac aagaatctaa aatattattg catataaacc 99120attcaagagg attaagaaat attttagttg aagaaggaaa tagaatatta gatactgata 99180acgagtatat ttatagagat acatttagaa agtatcttaa atatctactt aatttagaag 99240aataccaatg gttgagagag gtatctaaag gctctatatc ttatttatgt gataagttat 99300accaacagta taaaaggtat tttaataaag tttctaacaa acctaagttt aaatctaaaa 99360gaaatgctaa aatgtattat tatccaagaa gtgatagtaa agataaattt tacttagata 99420aaaataataa attgcaaatt gaaaaattag gtcgagttaa aatatctaaa ggtactttaa 99480aatctaattt aactaaatta aaacttatag agaaaaatga tagattaaga caatctatta 99540ttacttttga tggaaaatac tggtatatat ctatttcata taaagttagt gctttaagtg 99600agaaccaagc taaaaaagaa ttaactaatg aagttatagg tatagactta ggtattaaga 99660cattagcaac ttgttcaaat ggtaaatctt ataaaaatat taataaaaca aaaagagtta 99720agacacttga aagaagatta aaaagaaagc aaagacaact tttacgtaag tatgaaataa 99780ataaggatta ctttactatt tgtttacttg atgagaaggg taaacctaaa cgtaataaaa 99840gtaatggaga agttattcaa aagaacataa gaaaaacaca aaatattatt aagttagaac 99900aagaaattaa actcttacac agaaaactta ctaatatacg taaaacttat gtacatactg 99960taacaaaaga acttgttgaa gaattaccac aagaaataat catagaagat ttgaaagtaa 100020gtaacttgat gaagaataaa tatttggcac caagtattgc taaagtaact tggtatcgat 100080ttagagaata tcttacctat aaatgtaaag atagaggtat attacttaca gtagcaaata 100140ctttctaccc ttcaagtcaa ttatgttcag tgtgtggtaa tcgtaaaaat aagcaaaaca 100200aacttaatct taaacagaga atttataatt gtgagtgtgg taatacactt gatagggatt 100260ataatgcaag tcttaacttg aaaaactata gatactccaa ttggtatcat gaaaatgtta 100320atctcaagct aactaaaaca gattaacctt atgtacctgt ccgtaacagg gaattgaaag 100380cctttggagt gctatagcaa ctttagtaga agtcataaaa agtaattcta tttatagaac 100440gaaagatttc gaggaagagt acgtagaaga aggaataaaa tttatagtaa ttaagttaat 100500tatttataag ttttaactta cggaacaaaa acgtattgat ttagctatta gttttgctat 100560ccaagactta attatgagta aagaagatat atctacaaat atagcccttt acgatgaatg 100620ctttgacgga ctagacacta ttggttgtga gaacgtagtt aaactactaa aagatagact 100680aaaaacagta ggtactattt ttgttattac tcataataag agtctagcac ctttatttga 100740gaatacaatt acggtagtaa aagaaaatgg tgtagctaca ctaagaaagg aattaaataa 100800tgaaattaaa gattaaagat aaccagtttg catctttaac agtaaattat acaaacaatg 100860caaagttaca tatagataat attcctgttt ctactttagt agactggtac cctttaagta 100920atgcatacga gtataaagct agtaatgact ttggatatat tgaactaaag agattacgct 100980ctagcttacc tgtgtcttat gggttaactc accaaacctt atataaatgt gaaactgtta 101040aatgtaaatt aggattatgg tataatgaaa aaataaaaga agataatgag aaaattattg 101100agaaagctaa gttgtacggt ttacctacta tagatgaacc cttcacaagt aaagatgtaa 101160agcaaggatt tagtgactta ggtgttattt tccaaacgct aaaaacaatc agtacaaacg 101220agtacttaaa agataaaaca attgaagaga ttaacacctt tagtaagaaa tcagaggatt 101280atcaattaaa tgaagtactc aagtacagta caacactggt agatgatact tatagtgact 101340taagtcaaat ctataatatg ttactattaa tgaagaaaat tgtttctata taggaagtga 101400ctgaaaatga ggtttgaaga ctttttaagt caagagattg gaacacctaa agagaatact 101460gtaggagaat tacgatattg ttgtcctttt tgtagggaac agaaatacaa gttttatgtt 101520aagcagtctt tagactctac taatggtatg tatcattgta agaagtgtgg agaacatggt 101580aaccctatta cttttatgaa gtcttattat agtattacag gtagacaagc ttttgagtta 101640ctagaaacaa agaatattga tatacaattc tcaccaacat tagaaatata taacacagat 101700ttaactgaaa gtgagaaatt attactaagg cttaatggat atacaaaaga taatagtagt 101760ataaaatcaa aagcacctga actacctata gggtttaaat cgattaaaga taacttaaat 101820aataaagaag tagtaccgta cttaagatat ctcaagaata gaggtattac actacagcaa 101880atcctagatt acaacatagg ttatattaca gatggttatt gttattctta tggtattaat 101940aatgagaaaa agaaaatagt acttagaaat agtgttatat tttttactta tgataatgaa 102000ggtaagtata tatattggaa cacaagaagt attgaaacta atccatatat taaatctata 102060aatgcacctt ctaaacctaa tgaatatggt aagagtgatg ttatatttaa tttaaatata 102120gctagtaaac aaaagtttgt cgttataact gaaggtgttt ttgatgcgct tacctttgac 102180agatacggta tagccacttt tggcaaacaa gtttcaaaga cacaagttaa caacctcatt 102240tcaagtattc ctaaagaaac acctatatat attatgttag acacagacgc tacagacttt 102300agtattaatt tagctagtaa acttatcatg cattttaatg tagtgtactt agtacctcat 102360ggtaatgaag acgctaatga tatgggtatg gaaaaagctt ttagtacttt gaaacacaat 102420agatttttag ttacacctga aagtactcaa agttacaaac tacaacaaaa gttaaaactt 102480taatcctgta ctataatgta taatgtgtta taatacatat ataaaaataa aggaagtgtt 102540agtgtggaag agaaagagaa agatattcta caatttgtag atgaatatgt tacagcatta 102600cgtgtaggta atgaacagcg tatgcaccaa ttagaagagt taggcaaaga acaaacagca 102660actttaacag atgttatgaa agctattact aacttattgt taggtgttaa taaacaaatg 102720gttgacctag agcaaaatac agagttaaac ttaaacattc taattgatgc tttatacaaa 102780gctgagttag ttaacgatga cgtattaaaa tatattgagg aagcaattga agaatcaaaa 102840gaaaaggatg aagaataatg gaaaaaaata ttagtacaca tacaaaaggt atttcacaaa 102900aagatatgga catgtggtta gaagctatta cacaaggaac agtagaaggc aaggaattaa 102960ctgaggacac tgctaagcaa ttacaccgta ttggagcacg tagtgtatca ttagatgaag 103020ctactagaat tgcacgagca attaatacca ttacagttca agagtatgca tctgctttta 103080atgatgcttt taatgctatt gatttgttaa tgattgttat ggaagataac ctagatgtaa 103140ctactgagca agtagagaag gcgcaactta aattaaaaga aaaacgtgaa aagtatttag 103200aagaaaaaca agaagaagta agaaaaaaac aagaagagca taaagcaaaa gaagataatg 103260aaaaagtagt gcagttgaag aaacatgaca aatagtaaaa aaaaaggtga tgtattcgaa 103320agaaagattg ccaaagaact ttctgattgg tggggttatc cttttagtag gtctccacaa 103380tcaggaggtg catcatgggg agctaacaat aatgctgtcg gtgacattgt agcaccttta 103440gagtctaatt ttccattagt tgtagagtgc aaacatagag aaaattggat tatggacaat 103500gttttactta ataataaaga acctcataca tggtgggaac aagttatagg agatagctta 103560caagttaata aaactccttg tttaatattt acaagaaata gagcacagtc atatgtagca 103620ttaccttata tagaagatgt atatgtaaag ttaagagatg gagagtaccc tattatgaga 103680acggatttta ttgtagaaaa tgttagaaaa gataaacatt tttatgatgt tcttataact 103740acgatagatg ggttgactaa cttaacacct tcttatatta tatcttgcta caacaaaata 103800gagattaaac catatagagt tgtcaagtct aaaatatcta aagttagtaa aaaagaagat 103860aagttgattg atgatttact tgatggtata taaggaaggg atactagttg attacacaaa 103920taaaaaaacg tgatggttcc gttgtagatt atgatttaag taaagttact aatgctattt 103980taagagccaa ctcagaaaca gaagaatata ttgaagatgt tattgattct cttgtagatg 104040acgtagactc tttactagaa gaacaagaca ctatcattac tgtagaatta atacaagata 104100tagtggagga agttttattt agtagtatgt ataaagatac tgctaaagct tttattttat 104160atagggataa aaagaaaaga gagcgtaaaa gagacctatt caaaccaaga aaagaattaa 104220aaccctatga ataccctgaa ttattagaat ataaagatgc tatacgccaa agttactggg 104280tacacaccga gtttaactat acatcagata ttcaagatta taagaataac gttaaataca 104340atgagcaaat gaccattaaa aaagctatgc tagcaattgc tcaagtagaa gtagcagtaa 104400agactttctg gggtgaccta tatcatagaa tgcctaaatg ggaaacagga gctgtaggtg 104460caacttttag tgagagtgaa gcacgtcatg cagacgctta ttcacattta ttagagattt 104520taggtttaaa tgaagagttt aaaacaatcg ataatatacc tgctcttaaa gaacgtgttg 104580atgagttagc aatgcatgta aaactaagta agagtgagga tgatagagac tacgtattat 104640ctgttttatt attttctata tttattgaac atgtatcttt atttagtcaa tttttaatta 104700tgatgagttt taataaatat aaaaacttat ttagaggttt atcaaatgct attgaagcta 104760catctaaaga agagcaaatt catggtttat ttggaacaga aatcattaat attcttagag 104820aagaaagacc tgagtggttc aacaaagaaa tggaagatgc agtttacaca gcgtgtaaaa 104880aatcttatga atcggaaaca cgtttacttg attggatgta tgaagatggg gaactagagt 104940tcttacctaa gaaagtagta caagaattta ttaaaaatag acttaataac tctctagtag 105000ctgttggata taataaactt tttgatgttg atgaagagtt actaagtgaa gtgtcatggt 105060ttgatgatga agttattagt actaagttaa cggacttttt atctaaacgt tctgtaaact 105120atacaaaatt tagtaattct gtaacggaag atactatttt ttcaacggaa tctgattttg 105180aaaatactgg taaacgagtt actaaagata aagtaaacgc tattttaaga ctaaaaatga 105240tataaaggca gtgtatatag atgagtaatt ttgaatggtt gaataatgat tctagagttt 105300ttctagaacg tggttattta agtgatggtg aaacaccaga acaaagaatt aaagatattg 105360cagattatgc tgaagatatc ttagatattg atggtttttc tgacaagttt tatgattata 105420tgagtaaagg ttattattcc ttatctagtc ctatatggtc taatttcggg aaagatagag 105480gatttagtat tagttgtttt ggtagttggg tagatgatac tataccatcg atacttaata 105540ctgctagtga agtaggtatg atgagtaaat acggtggtgg tacaagtggt tacttcggta 105600acatcagacc tagaggctca gaaatcactg ataatggact gacaagtggt tccgttcatt 105660ttatgaagct atttgagcaa atgacagata cgataagtca gggtagccaa agaagaggaa 105720gatttagccc ttatctacct atagaacaca aagatattga cgagttttta gagattggta 105780ccgaaggtaa tccaattcaa aacttaacac atgcggtaac agttactgat gattggttat 105840tagacatgat taatggggac aaagaaaaaa gaaaaacatg ggctaaagta ttaacaagaa 105900gaacacaaat aggatacccc tatatcttct ttcatgataa tgcaaatagt aatacagtag 105960atgtatataa agacaaaggg ttaactatta ataattctaa cctttgtgtt gcaccataca 106020ctaaaatact gactgacgag ggatacaaag aaatagataa acttaaagac caaaaagtta 106080atgtatggaa tggtgaagaa tggtctgaag taacagttaa acaaactgga gaaaaccaag 106140aaatgttaaa agtaaaaact aatagtggtt ttgagttaga ctctacacct tatcataaat 106200attacgtatt agaaacaact aaatcaggta aaagagcaag aaaaaataaa tataaagaag 106260ttagagctaa agaccttaaa gtaggagata aattaattaa atttgattta cctgttattg 106320aaggtcaaaa agaactaaat tttgcttatg ataatggttt ctttactggt gatggaacac 106380taaatggtaa aaatcaagtt atctatttgt acggtgaaaa gcaaaaactt attgattatt 106440ttaaatctat agacaaatgg tcagaaagta aagaacagga tagacatgta ggtcttacta 106500aaaaattaga agataaatat tttgttccaa tgaacgagta cactattgat agtagattaa 106560aatggttagc aggtttctta gatgcagatg gtacagtaac aaataataat ggttctcagt 106620ctattcaagc aggttcaatt aacaaagagt ttttaaaaga tgtacaatta atgttgcaaa 106680cattaggagt agatagtaaa gtaactctag gtaaaaaaga gggaacttct atgatgccag 106740ctaatgatgg tactggagaa tataaagaat ttaagacaaa agagctatat agaatattaa 106800taaatggtaa ttctttatat aaattaaatc aattaggtct tgaatgtaat agacttacat 106860gggaaacaaa agaacctaac agagaatgtt ctcaattcat aaaagtaaca ggaattgaag 106920aaattgaaaa aacaatggat actttctgtt tcacagaacc taagagacat atgggaatgt 106980ttaatggtat tttaacaggt caatgttctg aaattatgtt acctaataaa gaagattggt 107040catttgtatg tgacctatct agtatgaacc ttgttaagta tgatgagtgg aaacacacgg 107100atgctgtaga gacacttgtt tactttttag atgctgttat gtctgagttt attagagact 107160tagaatatct aagagactca gatgaaaaag ataagcaaga agcatttaaa tttatggaga 107220gagcttataa cttttctgtt gagaacagag ccctaggaat aggcgtgctt ggatatcatt 107280catacctaca atcaaaactc ataccttttg aaagtattag agctagccaa attaatgaag 107340agatatttaa attattaaaa gaaaaaactt ataaagctag tgagcagtta gctaaacttt 107400atggagagcc ttctatttta aaaggttatg gtagaaggaa ttcgtgtttg atggcggtag 107460caccttaatt tatagggcgt atatggatta acatatatga taacactctt gaatttctga 107520aaagcctaag tgtgtaaaca taaggtaatc agaagctaag atttatttat agttaacttg 107580acaaaaacaa atatatacat tatactagtt actaagaggt gataataaat gtggaaaaat 107640agtattagtt ttcctaggct cgaagtaact aaggatggaa gagtaagaat gtggaataaa 107700tcatggaaaa gatatgtaga aaaaagacat aggtatgata aagatggtta ctcaataatt 107760tctacaagaa aagaagatgg tacatccaca tcagcaagag ttcatagatt agtagcagaa 107820gcgtatatac caaacccata caataaacct gttgtaaatc ataagaatgg gattaaagat 107880gataataggg ttgaaaattt agaatggact actatatcag aaaatactaa acatggttat 107940gatgttttag gtgttaaaca cgctaacgct caactaattt tagtctactt agatggcaaa 108000cctttttcta gttatgactc cttaacttta atgggtaaaa cattaggtat aaatagaaat 108060cttatacgta gagtagaaaa agaaactgat gggtacatct catttaaatg gatagaaaaa 108120ccatataaag tacacaataa agatttttgg aaaacatcaa gaaaattaaa tacgagaggc 108180tcttgttatg ttgtaaataa tgtatactat aatagtgcaa aaaaagctat ggaggctctt 108240aaagtaagac aagatgtttt ctataataga cttaaaaaag ataaaaatgt atatagtgta 108300agtattaaag agtacttaaa aaattgtcaa gatataaata gataaagttc aacgactatc 108360ctgttgcggg gagtacactc aagtgagtgg aagtgggagt ggtcttacat ttagtaagat 108420gtgatatagt ctgctctcta tggaaacata gagctgttat taaattaacg catgtaaagt 108480aacgaactac atggaacata aaggacaaca agttcatcat ttatcctagg tcaagtttct 108540aaatcaattg agccttttat gagtaattac tacgttgtag acactgctaa agtaaagaaa 108600actatgatta atccttacct taaaaaatta ttaaaagaaa aaggaaaaga caataaaaaa 108660gttattgaga gtatcaggga taatgatggt tccgtacaac acctaacctt cttaagtgat 108720tatgaaaaag aagtatttaa aacatatggt gaaattaatc aatataatat attagaccaa 108780gcttctacaa gacaaaaata tattgaccaa gggcaatcta taaacattat gattaatcct 108840aagcatgtta cagcagagga gttaaatgaa ctttatctct ttgcatggtc taatggtatt 108900aagtcattgt attatcagca tggtacaaat gcatcacagc aattcaattt atctaaaatt 108960tgtattaatt gtgaagccta aagaggtgac taaatgaata aaaaagaagc attagaacta 109020ctaaataaag tagaagttat atttaaatca aatgatattt tctcacaagt aagtaatgta 109080caagacccta ttaagatgtt taatagggag gacgatacta aagcagatag taaatcaagt 109140aaatttcagc tagagtttat ttataataca tatgtgtata ttcttatata cgaaggtaca 109200ttgaagctat ttaaagctga tggtacggag cagttaacac atgtagctga tattgaaaca 109260tttaaagata ttattgacac actagaaaag gatgatacag aaaatggaaa aagtgaatag 109320tttattagaa ttaaatacaa caattagaca aaaacaggat gttattgtca tggttacaca 109380agatgagtgt gctaaatgtg aaattttaaa aagtgtgatt cctctttttg aagcagaagg 109440ggatattact aaaccggttt atgttattaa cttagatgat aaagatgtag acagagaaaa 109500agcggtcaag ttatttgata tcatgagtac acctgtactt attggttata aagatgggga 109560acttgctaag aagttcgaag accaagtaac acctaaaaac ttaatggaat tagatttact 109620ttaatttgta attacctact acttatgcta tacttatatt agtaaaaggt agtaggtttt 109680ttcatgaaag gatgaatagt tatcgcaaaa aataaaacat taactatata taatagtgat 109740agatatttta atatacatgt aaaaaacaaa gatgaattat ctaaagctat taaagttaca 109800actttaaatg aggatgatat agaaaaagat atggatatct tagctaataa atcaactagg 109860tatatactaa gagacgataa acattacatg ctatttaatg agaagtataa caatgataag 109920ttgattgaaa aaatatgtaa gcatggtgga caagtaacat actataccga ttcagtagtt 109980ccttactatg tgcttaaaga cttatcagcc caccctaaat cctcagttgt atacagaatg 110040cgtagtaaat tcagtaacaa agagatggat aatatagctt tgagtttcat gggaacaaaa 110100gtcattattg atatttcagt tgtatttcct tacgtcaatc cttacgatat tattagaagt 110160ttatacgatg ttaaaacgaa tgtagacgag gttcatctat cattccctcg tattagttct 110220gtagacgcta aacaaggtaa gtactatacg tatgataaag aagcttataa actaaatcct 110280gagtatatac ttgattttgc agataaatta agagtttctt tgtccgtgtg gaaaatgtat 110340atctatattc ttgctagtaa agaaaataaa gattatgaaa taatagaaga cctacttact 110400gaattaaaaa gacaaagaaa gattaagatt taggtgattt tgtgagtaca gcaaatagaa 110460gagatatagc aagaaagata tctgagagta cagggtacta tatccaagac gtagaagaga 110520tactagaggc agaaacaaaa gctatttctg aattgttact tgaagattat gataaggtaa 110580agaatcataa gtactttcaa atagaagtag tagagcgtaa aggtaaaaaa gcatgggatg 110640gattaaataa aacatacttt acattaccta atagaaaagc actaaagttt aaacctttgt 110700ctgaactaga taaagttata gacgtactaa acaaagagga ttaaattcct ctttttttat 110760tgactattat taatagtcat gttatactgt atttaagtta aagaagggat tggtaatgat 110820atgaaagttt taattttata cgactatatc agggaggaac acttttcagt tggtagtgat 110880ggtagtgtta agaatgtatt actaaataca cctaatggta gagtattaaa acaactatta 110940tctaatattt ctggtattaa tcgagataga agtacaaaag attatgatat tgagttttta 111000tatcctatgg tgcctacacc tattaagaat aattatggta aaacaattaa gtaccaagac 111060gttaagttat ctgaagttaa accttactat gaaagaatga atcaaataat cataaacaat 111120aagtacgata ttattattcc tttaggtaag ctaggggtta aatatttatt aaatgtatca 111180gctattagta aagttagagg tgtacctaat aaagtaacta ttactagtga agataaaaaa 111240catgatgttt gggtattacc tacttatagc atagagtaca caaacgttaa taagaatagt 111300gagcgtcatg tagtagtaga ccttaagtta ttaggtaagt ttgtagaaca aggtgaagac 111360gtatttaaac ctaaagaagt taagtatgaa cttgttacaa gtattgagcg tgtaagagaa 111420atatttaata aagaagtaaa gaatgataat catgacggtg tagacattac cgcatgggat 111480ttagaaacta actcacttag tcctgataga gaaggaagta aacccttagt actatcaatg 111540agttgggaga atggtcaagg tgttacaata cctttatata aatcagactt tacttgggag 111600aatggacagc aagatattga tgaaattctt tccttactaa aagaatgggt agctagcaaa

111660gaagacatta aggtactaca taatgctact tatgatataa atttccttat ggcaacgcaa 111720ggtttcacaa actttgaaaa taatcaagac actaaggtag gttggtattt agctgtaaca 111780caagaacaag cagagtctct aagattatca gaccttgctt acgaagtaac agatgtagga 111840ggatatgaca aaccccttga agattttaaa gagtggtatg tattgaagct actacgattt 111900ttatcagata aactaaaaga aattaaaaaa gaaaataaaa aagttactaa gaaagaatat 111960aacataaaag caaatgagta tgatacttgg ttgaaaaata aactcgataa catcgatgta 112020gaactaacag atgaagatag gtattatggt atcacagaag agcaaaaaag atatttagag 112080ttaaaactaa cacctgaggt tattacaaag aatatgctta tggattctga atttaaagaa 112140gtagccgaat catcacctga gtatatgagt ttatctaaca aagctaaaga ttatgtatta 112200ggtacatcta ttaatttaat taacacgtat aaagacaata ctaaagttat taatgaggta 112260gatggaggtg actttaatta tgattggatt ccattagagc ttatgcatcc ttatgccagt 112320ggtgataccg atgtctgtag aagaatatac tgtgatgtta ttgaaaagtt aaaagaacaa 112380aatagaccta aagcattgga cttaatgtca ataagttacc ctagattaat tagaacatta 112440gctagaatac aatcaaatgg tttacattgt gacctagaat acatgcataa aaatgatgaa 112500ttttatatta atgagatgga aaaaacccac caagaaatta gagaacattg ggctatccaa 112560gaatttgagg agactaggta taatttatac caattagcct tagcagaaca tgagaagaaa 112620ccatctgata gaaataaaga aatacatgag tatagagcta aatttaaaga tgaaggttgg 112680aagtttaaac caagctcagg tgaccataaa ggtgaagtat tgtatagcat tttaggtata 112740cagttacctt atagtaaaga gacagttaag gataaacctt tcagtaatgg tactaaagaa 112800gatgagttat catggaaaga ttacaaaaca gatactaagt ctataaagat ggcattatct 112860ttggttgaga atgaagataa taaaaagcta ctagacttac ttatttatta tgcctctttg 112920caaactaaaa gaaattcttt tactaagaaa ttacctaaaa gagtaaataa gaatacacat 112980aatttacatg gtaactataa tagtacagga actgcatgta ttacaggtga ttctttagtt 113040attactgata aaggtataaa aaaaatagaa gacttatcaa ataatagaaa agaaaaagta 113100tttagtagta ttgatgtagg tattgttaat agacagggaa atttagaaaa agcttcacac 113160ttttattata gtggtgtaag aaatggatta aagattactt tagaagatgg tactacatta 113220actactactt taaaccaccc cttattacga aataattatt atagtaatac tggtagggtt 113280ctaaataaaa caaaacaaac aactaagcat ttactagata atgattgggt tgtagctgaa 113340gatttaaaaa taggtgatta tataaaaatg tcttataatt ctaatcttta taataatagt 113400tatattgatt tagatactaa agattttata tatagtaaag aaaaaagtat tacaaacaca 113460aaaagctata cactacctaa ttatgtatct gaagattttg ctgaatggta cggtatgtat 113520acagctgatg ggtctttttc tacaaataac ggttcattca gtataagatt aactaatagt 113580aatcttgaag ttaggaatag attctttaac ctaactaaag atttatttga tattacacca 113640tactacatta gtaataaaga tagaagtgat tctattgaat tttcttcaat tggtttaggt 113700agatggttag aacatatttt taatatgcaa agtaaagcat taaataaaga aatcccacaa 113760caaatattag atagccctaa aagtgtacaa caagcatttc ttaagggttt aagtttagat 113820actgcaacag aaaagaaaaa gtatcctagt ttgtactata atactgtatc taataaaatg 113880gctttacaaa taagaacaat gctaatgaat atgggtatct attgtaggta ttctataggt 113940aaagtttata aaaatattaa tagaaaagta caaaatgaat gctattctat acaaataact 114000tatgatgcat tagataaatt ttacgatgaa atagggttta ttgaaagtat taagcgtgat 114060agagtaaagt ataaatcaga aaatctaaag gcattaggca gaagaaacgg tattctttta 114120tatgataatg ttttattagg tagaataaag aaaattgaaa aaataaaaga tatggaattt 114180tttgatttac atgttcctag tagccattca tttgtagtta ataatattgt aaaccataat 114240actagcaggc tttctagtaa caaccctaac cttcagaatc ttcctgctca tacatctgat 114300gtaaataagt ttgattatca ccaccctatt aaacgttctt ttatctctag atttaaagat 114360ggtgtaattt tacaagccga ttacagtgcc ttagagatgc gtattacggc actatataca 114420gatgataaag aaatgttaga gatgttttta acaggacaag atattcataa aaatacggca 114480agtattatgt atggtaaaag tatgaaggac gtaacagcag aagaaagaca agccagtaaa 114540gctgtagcct ttggtttaat ttacggttaa caaaatatag ccgtagtaaa actaggtaaa 114600cctattgagt atagggtgta tagttcacgt taggagctac aggaaatggt agttaagaac 114660tatgctaaca gggaaggctt taaaatgcta atcctgtgta gaataattta agtgtaattt 114720aataagtaag gatgatttaa atagaattta aaataggaga aagatataat cacaataagc 114780tatattctaa attagctcat gtatggtctc atatgataga tagatgttat aatcctaaat 114840gtaaggaata taaatattat ggattactag gaataacagt agacgataga tggcataatt 114900ttaataactt tcttaaggat gtagagttaa ttgatggttg gagtttagag aagtataaaa 114960atggtgagtt agtgttagat aaggatatta aagaactagg taataaagta tatagcttag 115020ataaatgtaa atgggctact agagaagaga acttaggatt tgtaccttca agaagtaaaa 115080agatattagg tatagaccct acaggtaaag aatatacatt cttcaatcag tctaaatttg 115140ctaaggaaca taacttaatt caaagccata tttctgcagt tcttagaggg gaaagaaaac 115200atcataagaa ctgggttttt aaaacactac aagaatataa ttatcaacct gtagaaaacc 115260cttctaaact ttatgcacct cactatgttg cttataagaa tcatgtggaa attgattatg 115320atagagtaaa aactaagcta ctaaagagac taaatatacc tacgtcaggc actaacttta 115380gaaaaatgga aaccggtgaa gattgttatg ggattacatt caaaatagag aaaagagaac 115440gatttgatta cacttaaaca cttaaattat tttatcgaac gactatcaaa aggtgagctt 115500tacgccgaga gggcttattg caatataacc gagtagagta catgtagctc atacctacat 115560ggaatagcct agaagtagat agtaacgtat ttacttaaga tatagtctag tcccctaata 115620aatatcggga aaccgagggt ataaacggag tcagagtttt cgtttgcagg taaaaataat 115680atgacagttg atgaagctac tgaaatattt gataagtttt attctaataa acctgctatt 115740aagaagtcta tagatgaaac tcatgagttt gttcaaaaac atggatatgt agaaacaatg 115800aatggacaca gaagatatat acactcagca caatctagag ataaaaagat taaaaatgag 115860ggtcttagac agtcctttaa cacgattatt caaggtacag gtggttacct tactaacatg 115920gctattactt atattgacga ctttattcaa aataagaata tgaaatcgaa gttagtagct 115980actgttcatg atagtattgt agtagactca cctcctgaag aagttaatat tatggctaaa 116040gttattgtcc atgtaatgga gaaccttcct tatgatttct taaaaataaa aattaatggt 116100gagttaagac agtaccctat agatgcagat atagagatag gattaacata taatgatatg 116160gtagaataca acgaagagtt aataaagcaa tttaattcgt ataaaggata tattaagtat 116220aaattagcct tacaacaaat caaagactac tatgaatcag ataaactaac tgaggagcaa 116280tacaaacaaa aaacggaata tattaaaaat aatattgaca gttttaaagt tatatagtac 116340agtaaaatag aggagggtat tatggagata catttagata cattagattt caatgagtta 116400accttaaaag ataacaatgg aaacactcag acttttaata tccatgatga actaaaactt 116460agtgagtata caattcaaga cgaaatgtac caacagtcgt ctaaatttgc atggtgggct 116520tcattaaaag agcgtgtgag taattatgcc gaagcagagc aacgtaagct agaaaaaata 116580ggagctcaac ttaatctaca aattagagct caatatgaac aacagggaaa gaaacctaca 116640aaagaccaag tagagtctgc tgtatttctt tctgatgaat accaacagca agcacaggtt 116700gtagaagcat ggaactatag agaaaaacaa ttgcattaca ttgtaaaagc ttttgaaaca 116760cgtacaacta tgttagtaca gattagtgcg gaactaagac aaacaaataa aaatggtggt 116820attacaaatc catttacaca ttaaaaaagg agaagtatgc taaatatggc aagtgaagtt 116880aagaaatatt ttttagaatt agctgataaa aaaagactag catacatgga agagcacggt 116940atagacttta tcgttaatag agaaaggtat tcttggaaaa caaataaaaa aatgtttacc 117000atcttatgaa gaattgataa aagaaaaata aagtaaatgg tacggttgac agcaaaggaa 117060aaatatgtta tactaattaa gtaattttta aaataaaagg agaaaagata ttatggattt 117120taatcaattt attaatcagc aatcagaaaa gctacaatca agtggttttg acaatgaggt 117180agaagtatac aagccaaaac aacccgtttt gcgcttaggt aaagtaaaag atgctaacgg 117240taatcaaatc aataaagagt ctgcacttgt acgtgtacta ccgcctgtag aaggttctaa 117300tgagttcttt aaggaattta gaacattagg tattaactat gttaaaaaag acggggcaca 117360aaagttctct atgcttactt tacccgagaa agttaactca tctgttgtag acctttatgt 117420aaatacatgg ttaaagcaag gtgtacaatt tagtaacttc cctaataaac ctgcacgacg 117480agcatatatt catgtgattg aatactttaa tcaaaatggt caattagttc ctaacacaga 117540tgaacaaggt aatgttatta ttcaacctat ggagctatct aatacgggtc tgtctcaatt 117600gattgaccga ttaaaagata aaatgttatc accatcacct actgctacac atagttttat 117660ttcagcagat gatgcattcc ctattaatat tgctaaagct aaaaaaggtg aaaaatcatg 117720gaatgtaact gtttatccta cagtaaaatt aggtgcttta cctcaaggtt gggaacagca 117780gttatctgat ttagataagt tagctacacc aacagaggaa aataacccta actttgtaaa 117840ctggttgatt aacaatgtta ataacacaga agtttctcat gataatttta aattcaatag 117900agaaacaaac acattaggtg aagaaccatc aacgcaagca cctacgcaac aaagcataga 117960acagcagttg ccagataatt taggagggca aaataacaca caaccaaact ttaataatgt 118020acaacaacct gtaccacagg taccaccaca acaaaacaca caatttggtc aaggaacacc 118080tgtacaacaa gaaccacaaa cacaaagtaa tccatttgag aactttgatg caaacaatat 118140cgatgattct caaattccat tcaacacaaa tgaatcaaca ccagaacccc ctaaacaaaa 118200tcaacctaaa agtgtagatg atgtattagc aggtttagat ttataataat tttatagagt 118260gctaggatag cactctttta tttaaatttc acataaaagg atgatataat ggttagagca 118320aaaaaaggta aagaagtaga cattacaaat ttaaatacta ttgacttagg taaagagtta 118380ggtttaactt tactatcaga tagtaataga gcagatatta agaatatcat tcctactatg 118440attccacaat atgataggat tttaggtgga ggtattcctc ttggtagatt aaccgaggtc 118500tacggattac aagcctcagg taaatcgacc tttgcagtgc acttgtctaa aatatcaaca 118560caactaggag ttattacagt atggattgat gttgaaggta ccgctgataa tcagcgtatg 118620gaacaactag gtgtagatgt atctaaattg ttctcagtac aagctggtga aggtagactt 118680aaaaatatta ctgaactatc agtagaaact gtaggtaaag agttagaata ctggattgat 118740acatttaatg agaaagcacc aggtgttcct attttattta tttgggactc attaggagct 118800acacgtacgc aacgtgaaat tgaaggcggt attgacgaaa aacagcttgg ctcgaaagcg 118860acagctactc aaaaagtagt aaatgctatc tcacctaaac ttaatgatac aaacacaggt 118920ttaattatca ttaatcaagc acgtgataac ttaaatatga gtaaccctta tgatgaccct 118980attaaatcta caggaggaag ggcttttcaa catggtgcta gtttacgtat taaagtaact 119040aggggtaaag agtcggagtt aaaacagaat gatgttatga caggtaaacc tacgtataaa 119100ggtcatgtta tgcgtattga aactaagaag tctaagctta ctagacctgg tcaaaaagcg 119160gaagctgatt tattatcaga gtatgaagta ggttctgatg aagatactat ccaattaaat 119220ggtattgacc cttaccatat tatctataaa gaggctgttg agcgtggttt aattactaaa 119280ggaacatggc gtaattatgt tacgttaaat ggtgaagaaa ttaaaaagta tgataaagat 119340tgggtaccga cattaatgga caaccatgag ttatacttag aattatttaa tagagtttat 119400catgaaaact tccctaataa gtatgcacct ttaagcaata caaaagtaga cattacccaa 119460ctagaagagt ttaaagcatt acaagattac tacgaagagc ttagctctac taataaagag 119520actaaggaag atgtaaatga ataatctaat agatagaaat attaatagtg ttaaagaagc 119580attaggcagg gctaatacaa atgacgtatt gcccttacct tatattgaaa tagcagaacg 119640ttttaaaaaa gctagagata ctaaggaagc tattattgta gaagaagcag gctttcctta 119700cactgattct acagttatgt atattgagca tgtagagtca aggtgggcag ggggttattc 119760tttagtacgt tataatggtt ctatggttaa agtacctaaa acaatacatt attccgatat 119820ctatgtatca aatgatgtac acaggattaa gattatattt gagggagcac atccttatga 119880agaaagttaa taatgggaat agatatatta tagacttaga tggtattcct actgactttg 119940gtagagactt agacatgctt ttaaagagat ataaaaacct tagatggtca ttatttcata 120000ggtactctag aggtatgagt catgactttg aaaaacaaga gttacgggaa tacatagatg 120060agcagtttat taagttagtt aaggagtatg atatacaaag taaagtagat tttccaggat 120120atattaaaac gaaactaaca ctacgagtac agaacagtta tgttaagaag aacaataaat 120180ataaacgtac tgaacttgta ggtaaaacag attatacagt agagtcctta acacaggagt 120240taaatgtggg attagaagaa aatgaattac ttaattatgt ctttgatgac acacaattta 120300ctgaagtaca aagtgaactg ctaaaagaac tccttattaa tacagataaa gaagacaacg 120360catttattgt ttcaactgta gctaataggt tagaggtaga gcgtccagaa gtatctagag 120420agcttacaga acttaaagaa tatgttaaat ttaaaataaa tgcttaccac gaacaaaaca 120480gtagaagata cattagggac aacaaaatag atacacaaaa tcatgtatgg gaataacaca 120540aacaagcctt ccttttgtta tattattaat gaaaataata acatagggag gttttttcta 120600tgttataatg taaaaaataa tgattggagc ttaattatta tggctaagaa aaatattaat 120660gaagtattaa aacaagctac cgctactgta gcagataagt atttacaagt tcaagtagag 120720caagatggtt atacacgtac acaccgtggt cagtataact acaaagtagt agataataag 120780ggagaattat tcttataccc gattgaaaca gatggtagag gaaatattaa aattatgaaa 120840aaggctccta ttgtctatac agatggtgac caaattcatt ttgtagttaa tactgttaaa 120900gacccttaca accatgcttt tattagaact gaaaatatta aaggtaaaga taaaggtaaa 120960caattaattc aagcgttttt agcattcgtt gaagaccgtt tcagctttgg agtatacaat 121020gtattccttg ctaataacaa gaaggatgtt tttgctttag ttgatgctga aagtaaagat 121080gctaaaaaag tagtagatag taatgagaaa cctcatgaag acgtgagtgc tgagtttcct 121140gctagcccat tacgtaaaga cgttaagggt gtagattcag gagaaggtca aggagacact 121200tcagagcctt cagtacctaa aaatgtaaca gtaaccgcta aagaaacaac agctgatatt 121260acagctgaat aaacatacaa aggatgactt agtttggata aattaaattt atacaaaggt 121320gaccagctat taaaaagtga agagaaacaa gcaggtaaaa catcaattac aattgataac 121380ttaactgcta acacagacta cccacaaggt acatataaag tatctttctc taatgaatca 121440ggagaatcag aaaaagtaga tgttcctgcg tttaagacta aagatattaa agtagtatct 121500gttactttag atgttgaaag tttagattta aaagtaggag aaacacataa tttagtagct 121560acgattgaac ctagtaacgc aacaaaagct acttatacat ttacttcaga acatgatgat 121620attgctagtg tatcaagtaa aggtttaata gaagctaaag caaaaggtca aactacaatc 121680actgttacta ctgatgatgg taatcataca gatactgtaa ctgtagttgt taaagataaa 121740gtacctgaag ctcctacaaa tgtaactgta gaccctaaag aaacaacagc tgatattaca 121800gcataatcgg aggtaaaaat aaatggaaaa aacattaaaa gtatataaag atggtgaagt 121860agtaggtact aagactgctg aacaaacagg taaaacaact atttctatta gtggtttaac 121920agcagatact acgtatccta aaggaactta taaagtagca tactctaatg agtctggtga 121980atcagaaaag gtagatgtac ctgaatttaa gacagcacca catagtgagc tataataaat 122040taaagtccaa cttaattgtt gggctttttt ttattgactt atatttattt atatgctata 122100gttaaacaag aattaataaa ggaggtacta tatggatatt aaaacagtat acttaacttc 122160agataacgac catttgaaag ttaaaaaatt aatggaaagt aaggaaaagt atattgcagt 122220tacgtatgat aataaatcag taagtaaggt caatgtcgtt atggttatta atgttattaa 122280agacctagtg catatgtata ggtataaaat tgttgagtat gggttatcta ataatgataa 122340ggataaggaa atggtagggt atttattaga aaggattgag gattgatgtt atttatttta 122400aatgaagtag cttcacacac agaacattta tccgaaggta tagatatatt cgacgttgaa 122460agtgtagtat cttttgactc ggcattacat ttagctagtg ataatacata tgattctgtt 122520atttttttag gttttatata caataatgag gattacttaa agtataaaga attattaaag 122580gatacaaaat tatactttgt ttctaatata aacttacctg acaataagga gtttattaca 122640gtaggtgatg atttaaaata tttatcctta ttagagcaac ttgtagtatt agaagataaa 122700gacctagaca ttaactttag tcagtatact aaagacacgg cttctaagta cactgagttg 122760tttagcttta aatctactta tgaggaggca aaagaaatgg gtctagtagg ttaccccgca 122820gatatagtat tacctattat gactgacaag ttttacaacg taaatgattt gtatgtacta 122880tacgaagtag cacctgagta taaattacct ttagcatatg aatgccttaa ggataaagaa 122940aaaggtattg ttgttatagg ttcacaaaca agaggtacta gtgatatcct tactttctat 123000gtaaaaggtt atgatgttaa tagtgttgct aaaacattcg gagcatctta taatgaaaat 123060tctaatatat tcagtatatt tattgatagt catatccatg tgttaggtga gaatatgaat 123120aagtatttaa taacggaagg aagtatttat gagtaattat aaaacagtag aagagttaca 123180agcagttatt gtaggtgtgt ttcttaaaga tgaaggtaaa gtagttacct ctaaatttaa 123240taaagtatta gcaagttttg gtattgatag agtaaatcgc aatgaattaa aagatattgt 123300agataatatt aggaaagaca catacttaaa tgacttgaaa aataaagcag ttaaaggtga 123360agtgttatta gaggacttaa gagatgtaga agataaacaa gtatttgagg gtaatgatta 123420tcatgaagaa gtatcatctt atgtagtagc acatgaaaaa gaactatcta gactaagaga 123480attacgaaag attaatagac aaactgcata ccctactatt ttgtttgatg aattaaagcg 123540tactatggtt aatgagctca aaggtaataa gttactagac catagagtaa gtaagtatac 123600ttctactgag gaagaagaag agctggttat cttactgtcg gacttccatg taggttgtgc 123660ttttcaagat ttaactaatg agtataactt tgaggtacta aaaagaagat taaatcagct 123720actacaggaa actattaagg atattagtaa acgtggtatt agtaatgtta cagtatactt 123780tgtaggtgat ttaatagagc atattaatat gagagatgtt aaccaagctt ttgatactga 123840gttcactatg gcagagcagg tagcaaaagg aactagacta ttaatcgact tcttaacaga 123900attatctcca tatgtagagg gtaatttacg tttcggtatg atagcaggta accacgaccg 123960tgtacagggt aataagaacc aaaaagtata caatgatagt gtagcttata ttgtattgga 124020ttctttactg ctgttaaaag aaaacggtgt attagaaggt attgagatta tcgacaatag 124080aaaagatgta tatactatta aagacacagt atgtaactta aatattatta taaaccatgg 124140agatggactt aaaggtaaag gtaagcatat tcctaaattt attgagaaca ctcacattga 124200tttgttaatt acaggtcatg tacaccactt ctcagtaaca caagaagatt acaatagaat 124260gcatattgta gcaagtagtc ctatgggata taataattat gctaaagaac tacatctatc 124320tagaacaaaa ccatcacaac aactactatt tttaaacaaa aaaaataaag acattgatat 124380taaaactgta ttcttagatt agggagagat aatatggaca ttctatcaat tatagcctta 124440acattgctta tcattattat tgttaatacc acaatgaact ttgtaggtat gttacgtggt 124500gagcgtgaat tagtaaaaaa aggaggtaac cctctaccca attggcagta ctataatgtg 124560ttattaccta atttatgtgg tattatcctc ttaggtattg ttgtttattt tggagattca 124620atttataaaa ttacaacaag gttagaagtt ctttttgcta ttattgcgct tattgtaata 124680gatgtattgt taacagcgtt agtattatta gtattgagtt tcgtaacaaa aaataaagaa 124740tagtaaagaa gggagtctgg tttatacttg actctctttg ttatttatgg tatattagat 124800atgaggtgat ttttgttgca attaaatttt ggtaaatttg ataatgaaat tattaagaca 124860aaagtaagtg aaggtgtcta ctcttttaga ggtgttcctt attactacat agaacatgtc 124920caagatgaaa cttctgagta tgtattagta tataacatac atagtgttga tgatgaagta 124980ccacaaaaga aatataaaat agaaacagta agtaaaacta ttagaggtgg tacgatatta 125040agtaatacaa ttaagtcaat gctacctaat aataagaagt ataaaaaggt atatgaacct 125100cctatctttt tagctaatat tataccttta ggtacagata caactacagg ttctgtaggt 125160aaagggtttt tcgaaagaga aaaagataga gtaactatta cacaaaaaga aggcactaaa 125220gttatacatg gtgaatatac aggagtattt atatgtttat ctaatattaa atggattaag 125280tcctatactc ctttagacag tatattacaa tattatcaac gtattaaagg ggatagaata 125340aatgtctgag ataactaaat tctatgagca ggacattaaa gatttaatta gaacgaagag 125400acatatgttt aaagatgatg agataacaag taatatacaa gatattagaa tatttaatga 125460aaaagctatt tgtcaaggta aatgtagaac tgactgttta attcttgata gaaacggtac 125520tgttatgggt atagagataa aaacagaacg agactctaca caaagactta ataaacagtt 125580atactattat agtctagtat gtaagtatgt ttatgtgatg tgtcatgata agcatgtacc 125640taaagtagag caaatactaa aaaggtataa acaccatcat gtaggtatta tgagctatat 125700taactttaaa agcagtccag tagtaggtaa gtataaggaa gctacgcctt caccactaag 125760aagtccttat catacactaa atattttatg gaagcaacat ttaatgacta tacttaaaca 125820gttaagagat tataatacat atctaactgg atataactat agggagcacg gtaaaaatac 125880taacaatgaa ggcagttata tagaaggaac acaacgtatg agaatgaaaa agtcagctat 125940tattaaccaa gttattcatt atttaggtgt agagaactct tataagatat ttactagagg 126000tgttatctat ggttatagta ataggtggca gatattagaa gatgatttct ttaaagttat 126060acagaacgga gtgagggtat tatatggcaa agaggaaacc tgatacatta aaacctaaat 126120ctaacggata taaacatcaa cctgttaact ttgctcctac aggtaactta tcaggtagaa 126180gtacttcttt ttttaataaa aaaagaaaag atatatcaga tgaaagtatt gttgttaaat 126240acaaaccttt gtttgttaaa aggtttgata atattactgc tacagacatt aaaatacaaa 126300agaagtatgc gttagactta atcagtgaag ctgtgaatat aaagaagaaa tatcttgtaa 126360tgaagcaaaa aggtaaatta acacaaacta ttttacatac agatagagtt tattatgttt 126420atagaggtaa gaaattaata ggtaaatgta gcattcgtga acaacgtaca tttagaggta 126480cacatttaat ctacattttt agtactagac atagaatatc tatacgcaaa aatagtagat 126540tagataagaa aagaacacca aagaaaatga tatataaagg tggtaaataa tggttaaata 126600tttaagaaca aaagctaaaa aaacaaatat aagtacttta tttaagaaac tacaaagtaa 126660agatattaca ctattaggag tgtcctatga tagtgattat ttccctagcg gtgtaacaat

126720aataccttat ttagaggata tatcacaagt agaagatggt atagaattta cgaataaagt 126780aatagttact gagaacttaa aacctgctat tgtaggtatg aataatatga taagtgattc 126840aggactaggt tatgttaaaa cagagcagtt aaataaaaga ttagaaaata ctggattaat 126900gacagattta ttatctaaag gaacagaatt aacttcaaca aagaaagtag acattgtatc 126960aacttttatt gaacctacta ttatgtacca agatactact attaataaag aattaaaact 127020tagattatac actatcgaag atgtatcccc tttaaatgac tacacacatg ttgtatactt 127080actagtaact gataaacaat atgacggtca atcattcata ggtacattat gtaaccaagg 127140tacattaaac aaattagata ccctaaaagt tcttacatta ttcaaaggta ataatttaat 127200caatagaagt gtgttttctg ttaagttaga tacgaataaa tatcattata gtttatataa 127260tacacatgag accggtattt tctttttaga tgatgataaa gacttaatta ttgcttgtgg 127320tcaatcctat gtaaaagtta gatataaaga tattgttagt agtaaagtag agaaagttag 127380tgataataac tataaaatga ttgttaatct tgttggtaat gatgagctaa caattctctt 127440atagtataat actcccttaa atatgtatac taaggtataa gtatacgtat ataagggatt 127500ttttatatat atttttttca agtagttagt taatttttaa aaggtattat tcttatttta 127560aaattatatt tataaaacat taaaatacct tttaggtata gggttttaga aaaaagattt 127620atattgctta aaatagttac actatagtgt aaaaaattag aatatccttt atgaaaataa 127680aatagatgca gaaattgtga tatattatat agtgtaaagt ataaaacagt tgatttgata 127740aggttatgtg aatacacata ctccttattt tagttcacac atatgtaaag acacttgaga 127800caagaaggga atatataatg gctagaaaaa agaatttaag aaataaaaaa tctgatataa 127860aggtagttcc agataaggaa agtattctat ctaaactata taataataaa ctattaaggt 127920ctaaagtgga taatgctata gatgaagatg ttagttatga tgatattata gacctatgta 127980aagagtatga cttagagtta tccaaatctg ccattacaag atataagagt aaacgtaaag 128040aagctattga aaatggatgg gatttagggg aacttattga taaaagaaag aaagttagcg 128100ctactcaaat acagaaaaaa gaaaacccta tgaaagaatt agatagtgaa aattatacac 128160cttttgaact ggctacacag aatgtacaaa caatatatga tgacattcaa atactagata 128220tgattattca aaaaggtgct aaaggtttaa actttgtaga aacattagac cctgctttaa 128280tgattaaagc tatggaaaca aaagatagaa ttacgggtaa ccaactaaaa ggtatgtcat 128340tcataggact aagagaacta atgattaaac aacaagcaca agatactgct atgacagaag 128400ttatgcttga gtttattcct gaagataaac atgaagaagt tcttcaaaga atggagcaat 128460tacaagaaga gttctataaa aacttagatt tagatgaaga aggaagaaag ttaaaagata 128520cattagatag agtaggctat acaatataga taatgaggta atacatatga cagaagaaat 128580tagtttaatt ccaataaaag atgttaaacc acttacagat atagtagata ttataacaca 128640cctacataaa ggtgatgtac ttagagttaa acaagagaac caaggagata tattactcag 128700actaagtact ggaaaacata agtttactga agtgtcaaga gacttagata aagaaaccat 128760gttctataaa aggtattggg tactatacaa tgtatctatt aattctttac taacttttga 128820tgtttattta gaaaacgatt atgtagagtc tacaaaagtt aagttcccta agaacacaat 128880tgtagaatat gtaagagata atcaagaatc agatgtagct aaggttaaag atattttagt 128940agatagtaac ggtaattatt tctatgcact ttcaggagaa acatctttat ataatgaaga 129000taaacttaat aaaattaaaa attaatgatt gacacactca tatgggtgtg ttattctttt 129060attacaaaca ataaaaggag caattgatta tgattattac attaaatgaa gaagagaaag 129120cattattaga aaataaaagc aactatacgc cattaagtaa gaataaagag ttcaatacac 129180caaaagaaga atatattgtt acaagttata ataaaggtgt acctgtgact gatattgcta 129240aggaagctaa agtaagtatg ggtttgattt atacagtgtt aaacttctat aaagtaccta 129300agaaacataa gaaatctaga gtagcaaaac gtgtaaaaca tattactaat gataagaata 129360aagtacaagc cttaattaaa gattatcaat atatggactt acaaagtatc tataaaaagt 129420ataacattca taagaatggt ttatattata ttttagattt gtataatatt gaaagaaaat 129480cagatttaaa agagaaagcc ttagaagata ctatcgaggt agaataagag gtgtcatatg 129540cgcaaagaac gaattgtaga ttacttgtat aatgtaaaga acattgataa taatttaact 129600atacaaggaa tagaaaatag tttatttaac aaagaatctt tacaagactt agtacctgat 129660tttgatactt ctagtaaaga tattaatgaa agtaatttat acctatgtac aataccagaa 129720gattataact ccgaccatgt agaaagtggt cagtatatag gtatagatgt tggatatgta 129780tctgaagacc ctgcttttga ccatttaata ggtcaagttc ctagaagtgt atatgagaaa 129840gcgcatgtta tgcaaccact aattaagata gaaaatactg atatagatta tactcaggct 129900gatatgatta atgatattaa agtaggtaca agtattagtg atgtaaagat taaagataaa 129960ttaagtttaa tgtcaaataa tcttattaca catttagaaa ttgttgataa gtattacttt 130020gatagtagta tagaagaaac attattaaag tattatgagt taaagaatcc tgactattat 130080ttaaaacatt ttcttaaact aaaagaactt gtcggagaca atagaataat atattgtcct 130140ttactgttaa aatgtattaa agttatagac taagttatta tattataagt agtaaaggat 130200ggtgcgctat gagtaaaaaa gcaataattg cttatgtaat tatcttagtt atgttagcct 130260tatctatatc tacttattac gtatcctcat acttatatca tgaaaaaacc aaatcacaag 130320ttacagacca attaacacat cacggtaaac taaaaaaaga taagaatgta gagtatgtag 130380gggactatac acttaagaaa gtaatagaca acaaagcata ctttatggaa aaactaccta 130440cctatttacc aggaagaaca agtgataaaa gtattgatat gagatattat aggactagta 130500aatttagaga aggtgtaaac tttaaactta ttcgtatata cacagaggat aatgacaata 130560atccagtaca taaatatagg tttgaagcag tattaaataa aaagtaaagg tatgatagtc 130620tatgacagta gtaattatac tagtatgttt tgctattata tactacttat ttaacaaaga 130680ttgagtcaag tttatgcttg actctttttt tgcgttatgt tatagtttat ttataaggag 130740atgataaatg atgaaaaaaa gtgatttaga taatttgtat attgtggtcg taagtattaa 130800gaacggtgtt ttacctgatg agcgtataat tccaattggt ttagatgtac taagtaaagt 130860attagaaggt aaaactacat ggacagttaa gaaagaaatt aaacatacat ttggtaaaga 130920tgaattaaaa agatttaaag ataattacaa gttcttgcaa cataaaattg tagaccttgc 130980tacaaaagga tataggtagg tggtataaat ggatatagta aataaactca tgttaggttt 131040tattttattg ttttatgtag gtgtatttat ttggtactta tgggaagtct ggaaattaac 131100ttctttaata tctgatatag ttattaagta ttatgttcgt aaggagtggg ttaaaggttt 131160attaccttat ttgattcatc aagttattat tacgttagtt tgggctactc tagtattagt 131220accttttata cttagttata taatgataaa atatttgata ggaggttact aaatggaagt 131280agtatatgag aatgaatgta gagggtatta tatttgtgtt atagataatg aaggtaagta 131340tgaagtatca tcttttaaaa aatcagtaaa caaatatacc cctgaaatta tagggtatac 131400tacagaaaag ttaatcttgg aattaaaaat accatgtaca tatgtaaatg ctagtgaagt 131460agaaagtttt atgcaagaat taaaagtagc acgtattgcg cttgacaagt ttactaaaga 131520tttatataat aaaggcataa caaatattat attctaaagg gtggttagta tgtatacaga 131580aaaatataga aatttaatcc atattacaca tagtatcttg gttagtattc aagaattagc 131640aagtaattta ttaaataaag aagtaaaact agttacaaaa gaaaataagt atttatgtgt 131700tgtagatggt attattatgt taattgttga ggaaggatta gtatacacct attttgataa 131760ggtaggttta aaagtacctg aacgtattgc acttggtcat ttagcaaaga gtttacagtt 131820tacaatatcg gaatcaaata aagatttaga aaatcaaaaa taagtgttga cacctttaac 131880atgttgcttt atactaagag taacaaaacg ttagaggtga ttttttatgt gtaaagaaaa 131940agttcataga cagctatcta atgctataga aatattagca acttacaaag agtggtggtc 132000ttttccaaaa gaattaagta ccacagaaac atttaagatt attaactgga aagaagatac 132060attagtattt gaagttagag aatatggtaa gtatataggt aggtttagtg tagcaactcc 132120tattattgat tttcattatg atagaattaa aaatacaaca acacaatata tgataaatta 132180ttttgctaaa atagtatgta aagatatgta tgcgtattat aaattacaga gaggacagta 132240aaaaatgaaa aatttaaata aacaaaaacg cttgacgttg gaattgatta gtgataatct 132300aaatacacaa cataacttag atacatcggt tagtcttgta gattatagta taaaagactt 132360tacaaataga aaagtctatg taagaactaa aaaaggttta gaacttacta atatgaaagg 132420attaaaaaat actgattcac tggatttact atttaagtac ttagaattaa ttttaaaagg 132480ggatatgtag tatgctaaca ccagaacaaa gaacacaatt aaaagagtat caaaataaaa 132540tgacaaaaaa gaaaaaataa atgttgactt actaaataac aagttgtata attaacttaa 132600caaagaaaaa ggagattgat aaatatgaaa aacttatata aaattttaac aggagtattc 132660tttagcacta cactattatt aggaggttgt gcttactact cacaagaaga tacaccaaca 132720catgattata aagaagataa gaaagaaaat aagaaaaatg attcatctaa agtagaagaa 132780caagaaaata aacaaattca agaagacaac actgttcaaa ataaccaaca agataaccaa 132840gtacaaggta accaagcaca gcagaacgaa caaatgcaaa aagcaagcag aagtgaacat 132900aatggactat ctaatgctga gtatgcggac aaatacaatc agtatagaga agctcaacaa 132960gcacaagcag aattagaaaa cagaactgaa gcagataaag ctagtggtgg tggaggcgga 133020ggagcctcat ggaattatgc aggtgctaat gagagctttg agcaatggtt acaacgctcg 133080caacaagaaa agactgaggc tggagtacaa gcaaattaat aaaaggtata ggagaataac 133140aatgaaaaca ataacaaaag aagaactaca taaagtttta gaagagcata aattatggtt 133200agatagtaat agtgaagaag gagctaaagc agatttaagt tatactatct taagaaatgc 133260taatttagta gatgctgact taaggagtgc taatttaaga ggtgctgtct taaggtatgc 133320tgatttagag gatactaatt taagaggtgc tatcttaaaa ggtgcagatt taacaagagc 133380taacttaaca tgtgctaact taagctgtgt tgatttaggt gatgctaact tagaaggttc 133440tgttttatat ggaactgatt tatattatgc tgatttaaga aaagctaatt taacagattc 133500cagattaaat gaggctaatt tagaatatgc agacttaaca aataccaatt taacagatgc 133560taaattatcc caagcaagta ctcaaaatat caaaggacta aaagtatact ctatagataa 133620tattggaact tttaatggta aagtgactta tattcctagc ttagatagag tatacgcagg 133680gtgttggata ggtagtttag aagcgttttt agaaaagggg ttagagatga atgaaggaaa 133740taatagtaaa cttgaggaaa taagagatgc ttactgcttt tttagtaaac gtaaatagat 133800ataaggatga ttaattatga acattgtaga acaacgaaaa cccataaaga gtaagcatat 133860taacttaact aaacacgcat atgaacgtta tactttaaga gttaataaag atagtaaaga 133920acgtgcttgt cagtggtttg ctagtgcttt aatgcaagct acttttgagc atgcacaaga 133980agacggtaat gaagtatatg tatttaagaa ttacagaatt attattgata gacatctaac 134040tattattaca gttatagata ctgaagatga taattgggaa ggtataaagg aagcaagaga 134100acaaatagat acgtatatta aaggtaagct aaaaaaaact gttacacctc tatttactaa 134160gttagataga atagatatta gtatccatga agcgcatatc agcaggatta aaacaagaaa 134220ccctaagaca aaagatataa ttaacaaaaa tattattgaa cttgaaagaa ataaatctct 134280actactaaat agtatagaag gtgtaaagaa aacagcacat aagtattaca tagaattaaa 134340ggacatccat aaaagattaa aggactgata atagtgtatt taaaagattt aattgaagat 134400tatgtgaatc aagataaaga agtaattata acaattacaa gtaataaagt aattattgaa 134460gcagactatg atgttatttg tttgcctaag agcaaggttg atattaatga tttaaaagct 134520tatgtatatg gatttaatag atttaatact gagcaaatta tgttaaagga tgtggaataa 134580tacaagactt aaaaagaata acacagcctg aattagattc attgataggg aagcatgaac 134640aatggctagc tacaaatgaa aaagaaggag aaaagctctt tttacagtgt gtagatttaa 134700gaaatcttga ttttcattcc gctaaccttc aatattcaac tattgtaatg tctagtttat 134760gtggtgctaa cctaagttat tgtgatttaa gttatggtga tttaagttac aatgagtgta 134820tatctacgag atttacacat gctcgaatga aggatattga gttgcctcat actaacttag 134880agtgggctaa tttaataaaa gcaaacttag aaaatgcttg tttagctgaa gctaatataa 134940gtgaggtaga cgctaggtgg gctaatatga aaaatgctaa cttaaatatg gctaatttaa 135000aaggtgcaga ttttggtggt acaaacctaa ctaatacatc attatattat gctaacacgc 135060ttgacgtgtt tgggataagt atttatacta taagtaatgt gcttgatttt gacgagcacg 135120taacttattt acctgattat gatagaatta ttagtaatta taatgaatat acccttgaag 135180agtttggtaa actagaacct acgcttgagt ataaagaaga tagaataaaa gaagtataaa 135240agaaaattaa attagcttac aatttcttta aaggagtgaa agaacttgat aaaatttaat 135300tcagacgaac ataaacatat acttaatgtt atggataaat taccatatac ttgttggtta 135360gacactgtag atggtgagtc aggtgctgac ttcttatgtg tattgcatag aacacactat 135420gaacttactg aactaggtat aatgatttat agttatggta gttggtacat gataccttat 135480gacaaagaag atttaattga atatgcaata aaaagagata tagaggagga ggaagaggaa 135540tggtaagtac ggttattata tttttaattg ttttaggtat tatattgcta agtgtactaa 135600ttattgttat accagattta agcaaagcaa aaaaacgtaa aaaagatgca gatattaact 135660atagtcaata tattaataaa gacatggctt ctgagtacta tgaaaagtat atagtaccta 135720ctgaacacat tgttcaaacc aaagtaacag agataattga aaatataaag aaagagtata 135780ttgtctctac tgtaattatt gactcttcta gtaatgaaga caaaattatc ttacatgttg 135840atgataagta tttaaaaaag gtagtgtatg aagataggta tgaatgcatc tacgattcta 135900atacaaaata tcaatatgtt gttaatcact taacatatga atcaagtact ttattaaaac 135960aagatgaagt aaataaatta aaagatatac ttaataaagt acctgtcaca gctaagcata 136020catttaaaaa tgagatgctt aatcatagga atgaatatgt gttagattat attacaatat 136080atatttgtgg tgatttaact gctaaaatta caaagaatgg ttatgtacaa aaatttagta 136140cactagaaga tttttgtgac aagtatgaag cttactgtag atttgttaga attgatttat 136200atgactgggt aaaagaagta agaactatta atggatatag attagaggta gatattaaac 136260cttattttaa aattactgct actaaaacaa gtaagtatga atttgtagta agtgatgatg 136320tatctaaaat taaaatatat agggatgata tgttactaac tagtaggtat atacgaaaag 136380caattgatgt acaggaaata atagaggaaa cattgaacaa taatactatt gtattttaaa 136440aagtagaaag taggtaaatt ccttactttt ttcatatata agtgttgaca ttaataagcg 136500taaggtttat aatatgtata taagttaaat aattatagag gagataataa tcatgaaaaa 136560aatattaagt ttagttttac tcgtactaat tgtactaaca ataatcaatg tagtgaaaaa 136620ccaagagcaa gtagaacaaa gtaaccaaga atctcaaaat aatgaagatg tagatgacca 136680tacttcatac gtacctgata atgatggaga gcataaagac gttagtgaag aacgtaaaag 136740attatggggt acagagtatc aagaaggtga aacacataac ccaaatgcta aagtgtttaa 136800tcaagataca ggagaacagg ttcaataaga gtagaaggag cacttaatat agagattgat 136860gctaggaaat atatattaag taacctacaa aaaacattta aatactctaa tatagatagt 136920aaagaggtaa ttaaaagata tagacatgta tataggtaaa tggatagttt ataagtagta 136980ggtaagtaat taaaagaaag tcatatataa gtaataagta acacataaag aaacaacgtt 137040tgatagtata cagataagta ataggtaagt aaataattaa aagaaaacat ctactactac 137100tatcacttat attgtaagta cctatatata tatataccaa gtaataggta ataggtaagt 137160agtaacaaca gctaccgata ttacagatac cttgtatata gatgcatagt aagtagtaaa 137220taattaaaag aaaatagcta tatggtatac ctatatatat taagtagtag ataagtatta 137280agtagtagat acgtattaag tattaacaac agctacctgg gaattttata tataataagg 137340aatagataat aggtaagtag taagtaacaa gtagtaagta acaagtagta agtaacaagt 137400agtaagtaac aagtagtaag taacaagtag taagtaacaa gtagtaagta acaagtagta 137460agtaacaaca actacctggg aatttcttta catcccacct tcatagtgta taaatagtta 137520ggtgtctaac tatttatttt tatatagttt taactattgt gaactatgct tatgtagtat 137580taaactatgc tgaacctata gtaaactgtt ctaatgtata gttaaactaa gctgaagtag 137640tatttactgt gtacaaaggt atatttagta tcagatattg tgtatatggt atagtataat 137700tatgaacatt attattatta ttcatatata ttgtttgttt ttacagtact attgactcaa 137760ttttccctag agtaaaagtt taatatattt agcagtttcc gaacattaaa gaaattgtaa 137820gcactttgta tatatgtgtt gacactgtgt tgcttatagt gtatacttaa tgcataaagg 137880taaaggagat gatttataat gaagattaaa acagaagttt cgtttacaga gctaatgaat 137940atgtattaca aaggcagtat agacaaaggt cactactatt ctactaatag tcagtttatt 138000gttagtataa ctgatggtga ggtatcgttc tataatgtgt ttttccctaa tactacggtt 138060ggtacaccta atagtactac tatacctaat gatactagat ttattgtaga agcggttgta 138120gataccacta ctgaattatt tagtctagta actactttta agcaaggtag taacgtatta 138180aactcagtat ggtatagagt tagtattgat gagttatata atcattataa aagtaaaaat 138240aaagagttat tatcagttag tactgttgta gatgatgagt tagttactat atggaaagat 138300ggtaagatat tgtgatttgg tatatagtac tatttagtat acttatatgt atagttagtg 138360ttttaattct atacgtatct tacaaagaag gttttactat taggatacta ggttactgat 138420actactattt atactaacag aaattacaag atttagtatc aatacaagta atgctattct 138480atgtacagta cttgtattgt tatgtgtagt actagtatat agaggagtta aataaccgct 138540tctatatgaa actttatacc tatatctatt ataactatag gtattttttt atatttctta 138600cataaatgtg ttgattttat gtgtgttaag gtttatactt aatatataat taaaggagtg 138660aagttaatat ggatatgaat aaagaagtat tagaacgttt agatagttta ggtggtaagt 138720tagagcaagc aggtacacat ggttatgaat ccttaattaa atacacagtt actcaaggta 138780ttatagattt atgttcaata agtatattat tatctataac agctatctta taggtggctt 138840tgtataagtc agataaaaag tctaatgaag gtcatagtac cttattattt gagtttgttt 138900gtaagaatga aaaagagatt tcttctgcag gatgcacagt aattatattt gctgttactc 138960tgtctattat ttctttttta gtgctattaa taggcttgcc tattgctatt caagaaattt 139020ttaatccaga aggatatttg attaagagca ctatagatag tttaaagtag agtaatgtat 139080aaaggagtgg tatagtgtct aaaaaaagaa aagaaattaa agagtataag aaacagggtt 139140actctgttga gtatatagga agtattttag gtttatttgg tattggcgat gttttatact 139200atgtagaaac taataagaaa tacttaaagt caattagcgt aggtaaagat gacaaccaat 139260atgtatatga ctttaatggt tatgaatatc tatcaaaata taagttaaat atcaaagaag 139320aagaactaat gtctaaagct attgctcagt taagtatcaa aggcttaaag aactttaacg 139380gagtgaagca tgcttgggat gtaggttttt tagagcaagc ttttaatgta catcgtaaag 139440ctattgatat ggttaagctt aaactaagct ttgatgatga gggtaaccta tattatgaat 139500tagaattagg ttggattaat atttataaag agtatacagg tgtaaaagac tttcttaata 139560cagtagataa ctatctcaac ttcttctata aagatatagt cactagtggt cttgagttaa 139620aacaagtact atataatact tttatgggag gagattatga gtttgtagta tctccatata 139680aggttgaagt atatagggaa gttgagttaa ttgatataaa gaaattttac tctgatactt 139740atggaattta ttcctatggt tatggcacta atgtacataa acctttacaa acaattaagt 139800attatctgga ataccctatg aatgaagtat aaccacttca aatattatat aaaaggagtg 139860cttaatatga gtaacggaaa agtagcgtta attgggagta aggtattgga agactataat 139920atttatacaa ttatgagtga gaaacatata tacttaagag atagtgttga tgtggctttt 139980aatgatggga aggtattacc tatatacatt gatagtgtat taaaacaatt aagtaaagat 140040gataaaaatt tatatttttc tgaacaagat atagatatta gtaaacttac taatgacgag 140100tattatacag ttactaaaaa ataaaaggag aatagataat gagtagtaat aaaaaaaaat 140160agcagaaaga gttattgaga aatttttaga tgagactaat aaaggtgtag attttactaa 140220tcaagatgaa tttaaccgct tcttagataa tacagaagac ttgtatgaag tatctggtac 140280tcaaagagat aagattatta agtgtttaca aaacattgta gttactgtat ttatggataa 140340ggagaaataa caatgaaaac aataaaaaga aaaatagtac aagaaggtat gaacaaagaa 140400gaaactatga tggaagacga ttctgttgta atcaaaaaaa ttcaaaaaat aacaggcgga 140460gctattcttc ctttagccaa tggcaaggaa tatgtagtag tgtttagtaa agtagaccct 140520actaaattaa ttgtatttaa tgtggaaagt aatcaaatct atttaagtgg ctctggtttc 140580gatagtgaac tgtcttatgt agacagtaaa agcaacccta ttaccttaga aacagttagg 140640ttaatcacta atttattata acggttatta ggctcttaaa gattaagtta ttttatagga 140700taaatactac tagaaaatga ttatcgttta atatagaaat ataacgtccc tagtttaagg 140760gtcttaaata taaaggaggg tattagaatg actaaggttg taagtagagg gtatagtttt 140820gaagaacaag aagtaagtat gaactataat caaggacaat gggtgattta tgcaagtaga 140880aaaccttata ttactgatat tatgaaaaag taccctgata aggtggaagt attagaacaa 140940ttagaaaatg aaacaccagt attggttaaa gttgtattgg atgaagattt aattacatta 141000agaaaaccgg taagtaatga gcgcaaagag caaatgaaaa agattgctaa agaaagattt 141060ggtaaataat agagaggctg actttaatga acatcagtat gtacactaac acctgtaggg 141120actagattaa tattacaaga tatcttatag ggttatagtg tcattgagaa tgagtatgct 141180ttattaaggt tagttaaaga agataaacag tatttataat atcatattga agaagtagaa 141240gcggtttaat accacttctt ttttatatta tatttatatt ctgagtaatt atgttgtgtt 141300taatgttggc taataattgt ataccaattt gagcatagta tgtccgtttc aacatagtta 141360atctattaat ttgtatattt atctgttagt tatgtataaa tatttgttat tacttattta 141420tatatttgta tttcgtacta accgtacgac ttatcttttt aaaaagataa gaacaaaaca 141480gcgtatacct tgttgtttta cgctacgcta caacaaggta acgcctgtaa taagttattc 141540gtattaaaat actaacaact aattacttgt tgtttagatt ataacatatg tttatgagaa 141600ttagatgata atttagttac aacagcatta taataatatt acagttatgt tacaagttgc 141660taagtatgtt ttgttactac aatatattga atatgaaagc tttagacctt ttctgcagac 141720aagtaattat tacagttatg tatgataaaa ggtaagtatc agggattaaa ttaaggttgg

141780attaatgaag cggataagtt agatactgat taaaataaaa tactttacat tacctaaaac 141840ttatgataca cttaggatag gataaaggag gaatatcaat gaatattcaa gaagcaaagg 141900ataaattata cgatgaatta ctttatacag taagtctttg tgagggaaca gaagaagatt 141960tactagaact tattgagaat ttattttata tttacaatga cgagcctgca tttttaagta 142020aagacggtat gcaatatact attaaagagt ttatggagag aagaaaaaca ttagaaccta 142080tcttaactga attaggtata gggtacgcaa tgatagaata tcacacacat acagaatacg 142140agttagttac ttattcagta cttaaagtta tacagtatga tgtagataac tatactgtaa 142200ttattgatac taatagtgat aagaatatta agttatcaga tttaacatta gaagctgtta 142260aggatatttt gaatcaaatt aagtagctag ggttgtttta ccctagcttt ttcatatgct 142320tgtattgcct atttaactac cttatataag caagtaagta ttataggata aatactacct 142380aaaaagtatt accgttgaat atagacctat aagattaagt ctctcttact gttataaaca 142440tcataagtgt aaatctatga ttttcctaag tatcaggcgc tgttttccct ttatattaac 142500cgcttcaaac aacataaaaa aagattaggc tattaaccta atctataatt cttttatata 142560attcttttat ataattcttt tatataattc ttgtaattct ctttctaact tttttattgt 142620ttctatatca ttatttcttt taatagactg acatataaat gcaatacctt taatcaaatt 142680aaatggttat ttttacactg cattgtatac aattaaatcg atcgattata ataattaatt 142740taatctgtac tttctagttt cttctatata atagtaagaa atcatttctt taaaaaactt 142800tcgtataacc tattgacaat caatataaga tactgtaata taataagcgt agtaaacaaa 142860ccgaaaggaa ttgataggat atgaacgtaa atcaaattgg agatatacta atagaacttt 142920tagacatgga cggttacaaa agcaataact actatagaaa tgatttaaaa tattcaacac 142980attatcaagt taaatattta gcttacattg atgatagcta tgaaacacta gaactattta 143040aagaaacgaa agtctttagc gtatcacatt caaatagatt accaattaac attaatgtta 143100aggtagtgaa caaacactta tttatagagc tagataatac gttataccta gtgaatgaga 143160atgcagaaat tattaaagaa aaaaagttaa aataatagtt gacactagaa ctaagatagt 143220gtaatataat agatgtagta aacaaacaga aaaggaattg attaattatg aaaacactaa 143280ttactaacag taaaccatat aagaactacg gctatgaaat ggaacaattc gagagagaaa 143340acaacgtaat tatcacacga gcataccacg aaccaacaaa acaaggctat gaccttgtag 143400tacactacac ggaggttaaa taatatgaaa tatctagaat acattgaagg aacttataac 143460agaattaaag cacaaggttc tataataaat gactatagac tatggtcaga tatggaagaa 143520tgtgatgatt tatactatca tattaataaa gcttgtcatg ctctttacaa tagcaatgta 143580aaagaaatta caacaacaga caaatgcgtg aaactaacac ttgaaaatgg aaaaacaaaa 143640cttgttaaaa aaggttaaaa taatgtttga cattacattt aagatactgt aatataatag 143700atgtaataca aaaacaaaca aaagggagct aataacatga gagatataag aatagtttta 143760agagaaattg acgaggtaca gcaagcctta atatatggta ggaatagcag agagttagca 143820cgttttttac gtagacaact ggtaaaacta gagaaagaaa gacaagatat aaattggtca 143880tagccaaaag cctattacat aggcttaaaa aataaaaata agggattgat acacaatgat 143940taaagttaaa tataaaggca agaaataccg ctcaacacaa aatacagatg ctattgtaac 144000tattataggt ggtacagcag taatcacatt gatagactgg tttattagat tacaagagaa 144060tattaatata tttattagat aagggctaac cacccttatt tttttatgtc tatataaccg 144120cttcacatta gtgtaaaact tcccttattt ctttgatata atactttaca aatacgagct 144180tatactgtaa tatattaatt gtagtaagga acacaacaaa caaaaaaaga agagggattg 144240attacttatg aaaaactata aaactttaga agaattaaac caagattata cagttattag 144300aacacaaaac gaagcttcaa gcaaacgtaa taacttagat gttactgata tttatgttaa 144360tgattggggt ttgttacaat atggtattta ctttaacaaa ttcgataacg tgtacaatgt 144420agtttcaatg acatcaggaa acaagaaata taatattact gcttatgaac ttgatagctt 144480tattatggat gagttaaaca aacagttaga gttatttatt aatgcaggaa gactataaag 144540gaacacaaca aagaacagca aacaaataaa aaaaacttaa aaaagtttta aaaaagtgtt 144600gacactaaca tcaacatagt gtaatataat agatgtagta aacaaaaaca aacagaaaag 144660gattgattaa ttatgaaaaa cacagtaaaa gaaatggcaa acggaaacac taaacttgaa 144720agattattag ttttagcaat tgaggaagcg gttatgacag agcttgttga atatgatgca 144780ttagataaat acaaccactt agaacaacag ttattaaaca atgaaacatt aacacaagca 144840gaacgtaaac cagctaacat tgattatagc acttacgagg gagctatatt agcacaagac 144900aaagcagaac actttactaa cgttatctta aaccacatga acaaagaaca atttgaacaa 144960atgattatgg atattgaaac actagaattt aatgcagaac aaatgctatt ctaaggagac 145020attacacatg aacttatctg agaaagaact tatagatata atagacaacg ttaatagctt 145080cactggtatt gatgaagcta ttaacgaaat ggaaaacaaa caaacaacta aaggcagtga 145140caaagacagc ggaacgatta aacagtacaa tagtttagat gagttaagac aagactatga 145200cataacaaca ttagcaccag atgtaataaa agaattactg aataatcatt agtgtaaaac 145260ttcccaaaat aattaactaa aactattgca attaactgta gatttgatat aatgtaatta 145320aggaaaaaca aataaaagaa aaaggattga taaactatga aattacttaa ccaaatgaaa 145380caaacagcag aacttgaagg aattgaattt gacttattat taacagctat ctatgaaaca 145440atagagatag aagctgttga acaggattta ctatgtaaat acattcatat tgtaaaccaa 145500ttaaaagaga ataaagacat aacaccatta gaatatatac cttctaacct agactttaca 145560gacaatacaa caataagact agttgataat aaagtgtttg agttagcaga ttatatagtg 145620gaacatatga gtgttgaaga gtttaataaa cacattaaag actatgaaca aattaaagca 145680gaagatatag aaatgatgta aaacaaattg aaagggagtt aattcccttt ctttttttta 145740ttattaatta ggattgtata caataggtta atataaatat attatacggg ggcaggggta 145800aaatgccact aataccacac attttatatg tatatacc 145838

Claims

1. An isolated, purified bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1.

2. An isolated, purified bacteriophage comprising a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1.

3. An isolated, purified bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 2.

4. An isolated, purified bacteriophage comprising a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

5. The bacteriophage of claim 1, wherein the bacteriophage is resistant to blood complement inactivation.

6. A bacteriophage composition comprising one or more bacteriophage selected from a bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

7. The bacteriophage composition of claim 6, comprising two or more of the bacteriophage selected from the bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2; and wherein the composition's target bacteria range is more effective than the sum of the efficacy of individual bacteriophages in the composition.

8. The bacteriophage composition of claim 6, wherein the bacteriophage infect and kill Staphylococcus aureus.

9. The bacteriophage composition of claim 6, further comprising a storage media for storage at a temperature at or below 8.degree. C.

10. The bacteriophage composition of claim 6, wherein the bacteriophage is resistant to blood complement inactivation.

11. The bacteriophage composition of claim 6, wherein the one or more bacteriophage belong to the genus Silviavirus.

12. The composition of claim 6, wherein the composition comprises a bacteriophage comprising a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1.

13. The composition of claim 6, wherein the composition comprises a bacteriophage comprising the polynucleotide sequence of SEQ ID NO: 1.

14. The composition of claim 6, wherein the composition comprises a bacteriophage comprising a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

15. The composition of claim 6, wherein the composition comprises a bacteriophage comprising the polynucleotide sequence of SEQ ID NO: 2.

16. The composition of claim 6, wherein the composition comprises a bacteriophage comprising a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1 and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

17. The composition of claim 6, wherein the composition comprises a bacteriophage comprising the polynucleotide sequence of SEQ ID NO: 1 and a bacteriophage having a genome comprising the polynucleotide sequence of SEQ ID NO: 2.

18. The bacteriophage composition of claim 6, wherein the composition is substantially free of a bacterial component.

19. The composition of claim 18, wherein the bacterial component comprises bacterial host protein.

20. The composition of claim 6, wherein the composition further comprises a pharmaceutically acceptable carrier, diluent, excipient or combinations thereof.

21. The composition of claim 6, wherein the composition is a liquid, semi-liquid, solid, frozen, or lyophilized formulation.

22. The composition of claim 6, wherein the bacteriophages of the composition target one or more of vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), methicillin-resistant (MRSA) Staphylococcus aureus.

23. The composition of claim 22, wherein the bacteriophages infect and kill one or more of vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), methicillin-resistant Staphylococcus aureus (MRSA).

24. The composition of claim 6, wherein the composition comprises between 1.times.10.sup.8 and 1.times.10.sup.11 PFU of each bacteriophage.

25. The composition of claim 6, wherein the composition is to be administered at a dosage of at least 1.times.10.sup.9 PFU of total bacteriophages per milliliter.

26. The composition of claim 6, wherein the composition is stored at 2-8.degree. C.

27. The composition of claim 6, wherein at least one bacteriophage is obligately lytic.

28. The bacteriophage or composition of claim 6, wherein the sequence of at least one bacteriophage is genetically modified.

29. A method of treating a bacterial infection comprising administering the bacteriophage or composition of claim 6 to a subject in need of treatment.

30. Use of a composition according to claim 6 in the treatment of a S. aureus infection in a subject, the use comprising administering the composition to a subject suffering from a S. aureus infection.

31. Use of a composition comprising one or more distinct bacteriophages that target Staphylococcus aureus in the treatment of a subject with a Staphylococcus aureus bacterial infection comprising administering the composition to said subject; wherein at least one of said one or more bacteriophages is selected from a bacteriophage comprising a polynucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

32. The use of claim 31, wherein the bacteriophage is resistant to blood complement inactivation.

33. A bacterial host manufacturing strain comprising a bacteriophage wherein said bacteriophage comprises a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

34. A method of treating a subject with a bacterial infection comprising selecting a bacteriophage based upon resistance to blood complement inactivation and administering said bacteriophage to the subject.

35. The method of claim 34, comprising selecting a bacteriophage based upon resistance to complement C3 protein-mediated inactivation.

36. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

37. A method of treating a subject with a bacterial infection comprising administering to the subject one or more distinct bacteriophages selected from a bacteriophage comprising a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

38. The method of claim 37, wherein the bacterial infection is at least partially due to Staphylococcus aureus.

39. The method of claim 38, wherein the one or more distinct bacteriophages infect and kill Staphylococcus aureus.

40. A method of modifying the microbial flora in a subject comprising administering to said subject at least one bacteriophage that targets Staphylococcus aureus bacteria, wherein said bacteriophage comprises a polynucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1, and a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

41. The method of claim 37, wherein the bacteriophage is resistant to blood complement inactivation.

42. The method of claim 37, wherein the one or more phage are selected based upon resistance to complement C3 protein-mediated inactivation.

43. The method of claim 37, wherein the distinct bacteriophage belongs to the genus Silviavirus.

44. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1.

45. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence of SEQ ID NO: 1.

46. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

47. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence of SEQ ID NO: 2.

48. The method of claim 34, wherein the bacteriophage comprises a polynucleotide sequence with at least 90% identity to SEQ ID NO: 1 and a bacteriophage comprises a polynucleotide sequence with at least 90% identity to SEQ ID NO: 2.

49. The method of claim 34, wherein the method comprises administering a bacteriophage comprising the polynucleotide sequence of SEQ ID NO: 1 and a bacteriophage comprising the polynucleotide sequence of SEQ ID NO: 2.

50. The method of claim 34, wherein at least about 80% of bacteriophages retain lytic activity after exposure to human plasma for a time period between about 10 minutes and about 120 minutes.

51. The method of claim 50, wherein the time period is between about 10 minutes and about 90 minutes.

52. The method of claim 34, wherein the bacterial infection comprises a pulmonary infection, rhinosinusitis, urinary tract infection, intra-abdominal infection, skin infection, skin structure infection, bacteremia, septicemia, endocarditis, or an implant infection.

53. The method of claim 52, wherein the implant infection comprises a cardiac implant infection (e.g., ventricular assist device infection, pacemaker infection), prosthetic joint infection, or prosthetic valve endocarditis.

54. The method of claim 34, wherein the bacterial infection is bacteremia.

55. The method of claim 34, wherein the bacterial infection is resistant to an antibiotic.

56. The method of claim 34, wherein the bacteriophages are administered at 1.times.10.sup.8 to 1.times.10.sup.11 plaque forming units (PFU) of total bacteriophages.

57. The method of claim 34, wherein the bacteriophages are administered at between 1.times.10.sup.1 and 1.times.10.sup.11 PFU of each bacteriophage.

58. The method of claim 34, wherein the bacteriophage is administered in a dosage of one milliliter comprising 2.times.10.sup.9 PFU total bacteriophage.

59. The method of claim 34, wherein the method further comprises administration of an antibiotic.

60. The method of claim 59, wherein the antibiotic is from an antibiotic class selected from the group consisting of a fluoroquinolone, carbapenem, aminoglycoside, ansamycin, cephalosporin, penicillin, beta lactam, beta lactamase inhibitor, folate pathway inhibitor, fucidane, glycopeptide, glycylcycline, lincosamide, lipopeptide, macrolide, oxazolidinone, phenicol phosphonic acid, streptogramin, and tetracycline.

61. The method of claim 34, wherein the bacteriophage is administered intravenously.

62. The method of claim 34, wherein the bacteriophage is administered via intra-articular injection.

63. The method of claim 34, wherein the bacteriophage is administered via inhalation.

64. The method of claim 34, wherein the bacteriophage is administered via nebulization.

65. The method of claim 34, wherein the bacteriophage is administered at least every 6 hours.

66. The method of claim 34, wherein the bacteriophage is administered at least every 12 hours.

67. The method of claim 34, wherein the bacteriophage is administered at least every 24 hours.

68. The method of claim 34, wherein the bacteriophage is administered for at least 7 days.

69. The method of claim 34, wherein the subject is human.

70. The bacteriophage of claim 3, wherein the bacteriophage is resistant to blood complement inactivation.