Mutant Strains of Trichoderma Reesei

Abstract

The invention relates to a method for producing a protein in a filamentous fungus cell, comprising the overexpression of the TrAZF1 gene or of one of the variants thereof in said cell.

Description

[0001] The present invention relates to a method for producing a protein in a filamentous fungus cell, comprising the overexpression of the TrAZF1 gene or of a variant thereof, in said cell.

[0002] The possibility of producing ethanol from cellulose has received a lot of attention because of the availability of large amounts of raw material and also of the advantage of ethanol as a fuel. Cellulose-based natural raw materials for such a process are denoted "biomass". Many types of biomass, for example wood, agricultural residues, herbaceous crops and municipal solid waste, have been considered as potential raw materials for biofuel production. These materials consist mainly of cellulose, hemicellulose and lignin.

[0003] Cellulose is a polymer consisting of glucose molecules linked by beta-1,4 bonds, which are very resistant to degradation or to depolymerization. Once cellulose has been converted into glucose, the latter is easily fermented into biofuel, for example ethanol, using a yeast.

[0004] The oldest methods studied for converting cellulose to glucose are based on acid hydrolysis. This process can be carried out in the presence of concentrated or dilute acids. However, several drawbacks, such as poor recovery of the acid when concentrated acids are used and low glucose production in the context of the use of dilute acids, are detrimental to the cost-effectiveness of the acid hydrolysis process.

[0005] In order to overcome the drawbacks of the acid hydrolysis process, cellulose conversion processes have more recently related to enzymatic hydrolysis, using enzymes of cellulase type. The microorganisms comprising enzymes which hydrolyze cellulose are, for example, the fungi Trichoderma, Aspergillus, Humicola and Fusarium. This enzymatic hydrolysis of the lignocellulosic biomass (for example, cellulose), on an industrial scale, has however the drawback of being expensive.

[0006] In order to reduce the cost associated with enzymatic hydrolysis of lignocellulose, the industry is constantly searching for methods which are more productive or which give a better yield.

[0007] There is therefore a need to optimize the production of enzymes in the industrial process. In particular, there is an unsatisfied and long-anticipated need to develop a method for producing enzymes that is improved and economically advantageous.

[0008] The inventors have thus developed an improved method for producing a protein of interest in a filamentous fungus, in which the protein is in particular a cellulolytic enzyme.

[0009] Thus, the invention relates to a method for producing a protein in a filamentous fungus cell, comprising the overexpression of the TrAZF1 gene or of a variant thereof, in said cell.

[0010] The invention also relates to a filamentous fungus strain, preferably a Trichoderma reesei strain, overexpressing the TrAZF1 gene or a variant thereof. The expression "overexpressing the TrAZF1 gene or a variant thereof" is intended to mean that said strain possesses at least the TrAZF1 gene or a variant thereof, said gene or the variants thereof being expressed constitutively.

[0011] According to one embodiment, the filamentous fungus strain according to the invention, preferably Trichoderma reesei strain, comprises the endogenous TrAZF1 gene, said gene being under the control of a constitutive promoter. In this case, the endogenous TrAZF1 gene is present in the native genome of the strain, and the promoter has been modified, mutated or replaced, so as to be constitutive. According to another embodiment, the filamentous fungus strain according to the invention, preferably Trichoderma reesei strain, comprises, in addition to the TrAZF1 gene present in its genome, an additional copy of the TrAZF1 gene, said copy being expressed constitutively. It therefore comprises, in this case, at least two copies of the TrAZF1 gene, one of these copies being expressed constitutively.

[0012] This mutated strain according to the invention is characterized by an improvement in the production of cellulolytic enzymes compared with the same T. reesei strain which has not been modified, or compared with a reference T. reesei strain.

[0013] Trichoderma reesei is a cellulolytic filamentous fungus. Given the capacity of T. reesei to secrete large amounts of cellulases and hemicellulases, this strain is highly advantageous for the production of enzymes for converting plant biomass materials into bioproducts that are of industrial use, such as bioethanol.

[0014] The expression "T. reesei reference strain" is intended to mean a Trichoderma reesei strain chosen from the strains QM6a, NG14, RutC30 and QM9414. These strains are available to the public and have in particular been the subject of deposits made respectively under the numbers:

[0015] ATCC 13631 (strain QM6a);

[0016] ATCC 56767 (strain NG14);

[0017] ATCC 56765 (strain RutC30); and

[0018] ATCC 26921 (strain QM9414).

[0019] In one particular embodiment, the strain is the CL847 strain. This strain is a hyperproductive strain.

[0020] Among the filamentous fungi that can be used according to the invention, mention may be made of certain fungi of the phyla of the Ascomycetes (Ascomycota), of the Basidiomycetes (Basidiomycota) and of the Zygomycetes (Zygomycota). Typically, the fungi are chosen from the classes of the orbiliomycetes, of the pezizomycetes, of the dothideomycetes, of the eurotiomycetes, of the lecanoromycetes, of the leotiomycetes, of the sordariomycetes and of the saccharomycetes.

[0021] In particular, mention may be made of Trichoderma reesei, Arthrobotrys oligospora, Tuber melanosporum, Alternaria brassicicola, Baudoinia compniacensis, Cochliobolus heterostrophus, Cochliobolus sativus, Hysterium pulicare, Leptosphaeria maculans, Mycosphaerella pini, Mycosphaerella populorum, Phaeosphaeria nodorum, Pseudocercospora fijiensis, Pyrenophora teres, Pyrenophora tritici-repentis, Rhytidhysteron rufulum, Setosphaeria turcica, Zymoseptoria tritici, Ajellomyces capsulatus, Ajellomyces dermatitides, Arthroderma benhamiae, Arthroderma gypseum, Arthroderma otae, Aspergillus aculeatus, Aspergillus carbonarius, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, Coccidioides immitis, Coccidioides posadasii, Emericella nidulans, Neosartorya fischeri, Paracoccidioides brasiliensis, Paracoccidioides sp. lutzii, Penicillium chrysogenum, Penicillium marneffei, Talaromyces stipitatus, Trichophyton equinum, Trichophyton rubrum, Trichophyton tonsurans, Trichophyton verrucosum, Uncinocarpus reesei, Cladonia grayi, Botryotinia fuceliana, Geomyces destructans, Sclerotinia sclerotiorum, Acremonium alcalophilum, Chaetomium globosum, Colletotrichum higginsianum, Cryphonectria parasitica, Epichloe festucae, Fusarium oxysporum, Gaeumannomyces graminis, Gibberella moniliformis, Gibberella zeae, Glomerella graminicola, Magnaporthe grisea, Magnaporthe poae, Myceliophthora thermophila, Nectria haematococca, Neurospora crassa, Neurospora discreta, Neurospora tetrasperma, Podospora anserina, Sordaria macrospora, Thielavia terrestris, Trichoderma atroviride, Trichoderma vixens, Verticillium albo-atrum, Verticillium dahliae, Clavispora lusitaniae, Pichia membranifaciens, Scheffersomyces stipitis, Wickerhamomyces anomalus, Ceriporiopsis subvermispora, Fomitopsis pinicola, Phlebiopsis gigantea, Wallemia sebi, Melampsora larici-populina or Rhizopus oryzae. Preferably, the filamentous fungus that can be used according to the invention is Trichoderma reesei.

[0022] In the context of the present invention, the term "TrAZF1 gene" is intended to mean the gene of sequence SEQ ID NO:1 or SEQ ID NO:3. This gene encodes a transcription factor of which the native protein sequence is represented in SEQ ID NO:2. This sequence is available online under the GenBank accession number: XM 006961831.1 (T. reesei strain QM6a) and on the site dedicated to the T. reesei genome, under number ID103275 at the following address (http://genome.jgi.doe.gov/cgi-bin/dispGeneModel?db=Trire2&id=103275).

[0023] The sequence SEQ ID NO:1 is the nucleotide sequence of the TrAZF1 gene without intron. It is therefore the cDNA sequence.

[0024] The sequence SEQ ID NO:3 is the genomic nucleotide sequence of the TrAZF1 gene. It consists of four exons and three introns. It is reproduced below, and the three introns are highlighted:

TABLE-US-00001 (SEQ ID NO: 3) ATGGCCCTCGCAGCTCAACAGCATACTCAGGCCGATTGGGGCCGCTGG TCTCACCAGATTCCACAGAGTTTTCCCATGATGGGCTCTCCAGGATTCA TGTCATACGATCCCAGAGCTCAGGACGGCAGTCAGATGCAGCGTCAG GTGTCTGCTCAGTACCTGGTGAACTCGAACTACAACCAGCCCCCGATG CCCACTGCTTCGTCTCCCCAGTATCAACACGCAGGGCCATTTTCCTATG TGCCTTACCACAGCCCGCCGCCGTCCACTCCTCTTGGTTCCCCATTCAA GAGCGAATTTCCCGAGCACCCTCTTACGCGCATGACACACTCTACGGT CGATCGACACCATTCTCAGGCCATGAGGGACTACCAACCTTATTCTCC TGTATCGAGGAGGGGATCGATTTCTTCAGTCGCCACCAAGCCCTCAGC AGCTCCCGTCACACCAGGTCCAACTACTCCTGGCTCTTTCACTTCAAGT TCCGACGCCCAGAGCCCCAGCACTCCAAACCCCCAGACTGCGTCTCAG CCTGTCAGCTCCAAGACTCTCACTTACAATGAGACCGTTCATCCGGGC GATAGGATCAGCTTCAGAACCGATGTTGATGAACTCATGAAGGCCATC CAGAAGACACAGACGACCGACGAGTGTCAGCAAACACTCACACCTGC GCGAACACCAAAGAACTGTACCACAAGTACTCCCGTACTTCGTACACA AAGCGGGAAGCCGAGAAAACAGTGGGTTTGCGATGGCCCCAACTGCG GCAAGGCCTTTGTCCAGAAGACGCATCGCGACATTCACCGACGCACTC ACACCGGCCATCGACCATACGTACGCGCCCAGCTCCTCTTCACTGCAA CGCCGGCTAATTAAATGTTGATAGGTCTGCACCATGGAAAATTGCGGT CTTACGTTCTCGCAGCGAGGAAACCTCAAGGTAAGCTTCAGCTGCTAA GAATCTCCTTTGAGAATGCGTATACTGACCAGATGGTGTGTGGACAGA CTCACATACGACGCCACACAGGTGAAAAGCCGTTCTCTTGCGCTGCTT GTGGCAAGTGCTTCGCTCAGCGTGGGAATCTTCGATCCCACGAGGAGA CACACAAAGGCCTGAAGCCCTTCGTCTGCCGGCTCGATGATTGCAACA AGTCGTTTTCTCAGCTGGGCAATATGAAGGTATGCAACATCTAGCACA TGAAAGCAGTATGAGAACGCTCTAACGCTGAGGGAACTGCAGACTCA TCAGAACAACTTTCACAAAGAAACGCTCCAGAAACTCACACACATGTT TGTGCAATTCTCGGAGAACGGCGAGGTGCCCAGAGACTATCAGGATCT TTTCGAATACTTCCAGAAGCACTACAAGAATAGCAACAAGGGAGTCA AGGGCCGAGGAAAGACTCGCGCTGTGGCAGCTCGTGGGCCTCAAGAT TCCGCGTTTCGGCAGGCTGCCTCCCCAGTGCCCGCGTTACTGAAGACG CCGGCTACGACTCATTTGCCCCAGATGACAATGCCAGCCCATGATCCC CATGGCAGAATCTCACCATACGCCATGACCCAGGGAGCTGCGAACAC TCTGAGCAATGTCCTGCGCAACCCCAACCCCTCTTACGGCCTTTATGG ACCCACGTTTGCCCCGGGCCCTGTACGAGATGGCGTCTTTCACATGGG CATTGCGAGCCACCTATCCTGA

[0025] Thus, the sequence SEQ ID NO:1 corresponds to the sequence SEQ ID NO:3 without the introns.

[0026] A strain according to the invention therefore preferably comprises either at least two copies of the sequence SEQ ID NO:3 or at least one copy of the sequence SEQ ID NO:1.

[0027] The term "variant" of the TrAZF1 gene is intended to mean a gene encoding a protein having the same function as that of sequence SEQ ID NO:2, namely a transcription factor. Preferably, the variant of the TrAZF1 gene is an ortholog. Preferably, the variant of the TrAZF1 gene encodes a protein having the same function as that of sequence SEQ ID NO:2. Preferably, the variant of the TrAZF1 gene encodes a protein chosen from the sequences SEQ ID NO:6 to SEQ ID NO:140.

[0028] The inventors have now shown, for the first time, that the overexpression of the TrAZF1 gene results in a significant increase in the production of cellulolytic proteins.

[0029] In particular, the inventors have demonstrated that T. reesei strains RutC30 and CL847 mutated according to the invention, i.e. comprising two copies of the TrAZF1 gene, one of which is constitutively expressed, exhibit an improvement in the production of extracellular proteins, in particular of cellulolytic enzymes.

[0030] The proteins produced according to the invention are preferably cellulolytic enzymes, more preferentially cellulases or hemicellulases, even more preferentially they are cellulases.

[0031] The method according to the invention relates to the production of a protein in a filamentous fungus cell, comprising the overexpression of the TrAZF1 gene or of a variant thereof, in said cell.

[0032] This overexpression of the TrAZF1 gene is preferably carried out by introducing a cassette comprising said gene into the genome of the cell. The knowledge of such methods is part of the knowledge of those skilled in the art.

[0033] Preferably, this cassette comprises:

a) at least one constitutive promoter; b) the gene of sequence SEQ ID NO:1 or SEQ ID NO:3, or a variant thereof; and c) optionally, a terminator.

[0034] The constitutive promoter a) is a strong promoter. The term "constitutive promoter" is intended to mean a promoter which is not inducible. This constitutive promoter expresses the gene all the time; thus, a constant and strong production of proteins takes place.

[0035] This promoter can in particular originate from Trichoderma reesei, but also from Aspergillus nidulans.

[0036] Preferably, the constitutive promoter a) is chosen from:

[0037] the gpd promoter of Trichoderma reesei (Li J. et al (2012), Achieving efficient protein expression in Trichoderma reesei by using strong constitutive promoters, Microbial cell factories, 11(1), 84. doi:10.1186/1475-2859-11-84). This promoter has the sequence SEQ ID NO:4,

[0038] the gpd promoter of Aspergillus nidulans (Penttila M. et al (1987), A versatile transformation system for the cellulolytic filamentous fungus Trichoderma reesei, Gene, 61(2), 155-64; http://www.ncbi.nlm.nih.gov/pubmed/3127274), and

[0039] the tef1 promoter of Trichoderma reesei (Nakari-Setala T, Penttila M., Production of Trichoderma reesei cellulases on glucose-containing media, Applied and Environmental Microbiology. 1995; 61(10):3650-3655).

[0040] Preferably, the constitutive promoter a) is the gpd promoter of sequence SEQ ID NO:4.

[0041] The cassette used in the method of the invention also comprises the element b), i.e. the gene of sequence SEQ ID NO:1 or SEQ ID NO:3 or a variant thereof. The variant is as described above.

[0042] Finally, the cassette used in the method of the invention can optionally comprise a terminator c).

[0043] The terminator is preferably the gpd terminator of Trichoderma reesei, of sequence SEQ ID NO:5.

[0044] The present invention also relates to the use of a cassette as described above, for the production of proteins, in particular of cellulolytic enzymes.

[0045] The overexpression of the TrAZF1 gene is preferably carried out by introducing a DNA fragment comprising the TrAZF1 gene with a constitutive promoter, a terminator and a selectable marker. This cassette can also be introduced into the cell by a vector, such as plasmid, comprising the cassette. According to the invention, the term "vector" is intended to mean any DNA sequence into which it is possible to insert fragments of foreign nucleic acid, the vectors making it possible to introduce foreign DNA into a host cell. Examples of vectors are plasmids, cosmids, yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs) and bacteriophage P1-derived artificial chromosomes (PACs), and virus-derived vectors.

[0046] The vector according to the invention may also carry a selectable marker. The term "selectable marker" is intended to mean a gene of which the expression confers on the cells that contain it a characteristic which makes it possible to select them. It is for example an antibiotic-resistance gene.

[0047] Preferentially, said vector is a plasmid. More preferentially, the plasmid is a plasmid of pRS426 type, as described in the examples and in FIG. 1.

[0048] The cassette according to the invention, once inserted into the genome, allows the translation of the TrAZF1 gene of interest, which gives the corresponding protein.

[0049] The invention also relates to the use of the strain according to the invention for the production of cellulolytic enzymes. Thus, in one particular embodiment, the invention relates to the use of a Trichoderma reesei strain, for the production of cellulolytic enzymes, said strain overexpressing the TrAZF1 gene or a variant thereof.

[0050] The invention also relates to the use of the strain according to the invention, for the hydrolysis of cellulose and degradation products thereof, including cellobiose, to glucose.

[0051] A subject of the invention is also the use of the strain according to the invention, for the production of biofuel. According to the invention, the term "biofuel" can be defined as any product which results from the conversion of biomass and which can be used for energy purposes. Furthermore, and without wishing to be limited thereto, mention may be made, by way of example, of biogases, products which can be incorporated (optionally after subsequent conversion) into a fuel or which can be a fuel in their own right, such as alcohols, (ethanol, butanol and/or isopropanol depending on the type of fermented organism used), solvents (acetone), acids (butyric acid), lipids and derivatives thereof (short-chain or long-chain fatty acids, fatty acid esters), and also hydrogen.

[0052] Preferably, the biofuel according to the invention is an alcohol, for example ethanol, butanol and/or isopropanol. More preferentially, the biofuel according to the invention is ethanol. In another embodiment, the biofuel is biogas.

[0053] The invention also relates to the use of the strain according to the invention, for the hydrolysis of beta-oligosaccharides.

[0054] The following examples illustrate the invention without limiting the scope thereof.

FIGURES

[0055] FIG. 1: Representation of the pRS426 plasmid.

[0056] FIG. 2: Position of the primers used to verify the presence of the cassette for overexpression of the transformed strains.

[0057] FIG. 3: Production of extracellular proteins by the RutC30 strains transformed according to the invention and a RutC30 strain of T. reesei which has not been modified, after 7 days of culture.

[0058] FIG. 4: Production of extracellular proteins by the C1847 strains transformed according to the invention and a C1847 strain of T. reesei which has not been modified, after 7 days of culture.

[0059] FIG. 5: Specific production rate of the C1847 strain and two transformants under fed flask culture conditions.

EXAMPLES

Example 1: Lactose-Induction Transcriptomic Studies of the Trichoderma reesei Strains ATCC 56767 and ATCC 56765

[0060] In this study, the inventors used the following Trichoderma reesei strains:

[0061] ATCC 56767 (NG14), and

[0062] ATCC 56765 (RUTC30).

[0063] The RutC30 strain is derived by mutagenesis of the NG14 strain and has an increased cellulase production.

[0064] The TrAZF1 gene (ID 103275) is a transcription factor (protein involved in the regulation of other genes) identified as differentially expressed during kinetics of induction on lactose (Poggi-Parodi et al. 2014). More specifically, the transcriptomic study shows that the expression of TrAZF1 decreases during induction in the NG14 strain, whereas, in RutC30, its expression does not vary.

Example 2: Construction of an Overexpression Cassette for the TrAZF1 Gene

[0065] The overexpression cassette is made up of three DNA fragments:

[0066] the promoter region of the glyceraldehyde-3-phosphate dehydrogenase gene (GPDp) of T. reesei. The size of the promoter region was defined in the article by Li et al. 2012 (SEQ ID NO: 141);

[0067] the coding region of the gene of interest (TrAZF1) (SEQ ID NO: 3);

[0068] the terminator region of the glyceraldehyde-3-phosphate dehydrogenase gene (GPDt) of T. reesei. The size of the promoter region was defined in the article by Li et al. 2012 (SEQ ID NO: 142).

[0069] In order to be able to select the transformants, a cassette called HygroR (SEQ ID NO: 143) containing the Hph gene is fused with the overexpression cassette. The Hph gene encodes hygromycin B phosphotransferase responsible for resistance to hygromycin B. It was isolated from Escherichia coli. For the expression of the gene in Trichoderma reesei, the Hph gene is placed under the control of the promoter of the cpc-1 gene of Neurospora crassa (NCU04050) and the terminator of the trpC gene of Aspergillus nidulans (ANID_00648).

[0070] The pRS426 plasmid (ATCC 77107) was used as vector for the construction of the deletion cassette via in vivo recombination in S. cerevisiae according to a method based on the literature (Schuster et al. 2012). To do this, the plasmid was digested with EcoRI and XhoI (New England Biolabs) and purified by gel electrophoresis using the QIAquick Gel Extraction Kit (Qiagen). The pRS426 plasmid is represented in FIG. 1.

[0071] The parts of primers specific for the TrAZF1 gene of interest were designed on the basis of the ORF prediction in the version v2.0 of the genome (http://genome.jgi-psf.org/Trire2/Trire2.home.html).

[0072] Amplification of the Promoter Region of the Glyceraldehyde-3-Phosphate Dehydrogenase Gene of T. reesei GPDp

[0073] The primers used for the amplification of the promoter region GPDp from the DNA of the RutC30 strain are described below:

[0074] The forward primer consists of two parts: a part of 20 nucleotides (nt) which is a homolog of the pRS426 vector sequence (FIG. 1) in the vicinity of the XhoI restriction site and a part of 20 nt which is homologous to the 5' end of GPDp (SEQ ID NO: 141), the whole forming the sequence SEQ ID NO: 144 (ATTGGGTACCGGGCCCCCCCGACGCAGAAGAAGGAAATCG).

[0075] The reverse primer consists of two parts: a part of 10 nt homologous to the 5' end of the coding region of the TrAZF1 gene (SEQ ID NO: 3) and a part of 20 nt homologous to the 3' end of GPDp (SEQ ID NO: 141), the whole forming the sequence SEQ ID NO: 145 (CGAGGGCCATTTTGTATCTGCGAATTGAGC).

[0076] Amplification of the Coding Region of the TrAZF1 Gene of Interest

[0077] The primers used for the amplification of the TrAZF1 gene of interest from the DNA of the RutC30 strain are described below:

[0078] The forward primer consists of two parts: a part of 10 nt which is a homolog of the 3' end of GPDp (SEQ ID NO: 141) and a part of 20 nt homologous to the 5' coding region of the TrAZF1 gene (SEQ ID NO: 3), the whole forming the sequence SEQ ID NO: 146 (CAGATACAAAATGGCCCTCGCAGCTCAACA).

[0079] The reverse primer consists of two parts: a part of 10 nt homologous to the 5' end of the GPDt region (SEQ ID NO: 142) and a part of 20 nt homologous to the 3' coding region of the TrAZF1 gene (SEQ ID NO: 3), the whole forming the sequence SEQ ID NO: 147 (AACACAGCACTCAGGATAGGTGGCTCGCAATG).

[0080] Amplification of the Terminator Region of the Glyceraldehyde-3-Phosphate Dehydrogenase Gene of T. reesei GPDt

[0081] The primers used for the amplification of the terminator region GPDp from the DNA of the RutC30 strain are described below:

[0082] The forward primer consists of two parts: a part of 10 nt homologous to the 3' end of the coding region of the TrAZF1 gene (SEQ ID NO: 3) and a part of 20 nt homologous to the 5' end of GPDt (SEQ ID NO: 142), the whole forming the sequence SEQ ID NO: 148 (CCTATCCTGAGTGCTGTGTTCCTCAGAATG).

[0083] The reverse primer consists of two parts: a part of 10 nt homologous to the 5' end of the HygroR cassette (SEQ ID NO: 143) and a part of 20 nt homologous to the 3' end of GPDt (SEQ ID NO: 142), the whole forming the sequence SEQ ID NO: 149 (GGTACACTTGTTACGGATCTGATCACTCGG).

[0084] Amplification of the HygroR Cassette

[0085] The primers used for the amplification of the HygroR cassette are described below:

[0086] The forward primer consists of two parts: a part of 10 nt homologous to the 3' end of GPDt (SEQ ID NO: 142) and a part of 20 nt homologous to the 5' end of the HygroR cassette (SEQ ID NO: 143), the whole forming the sequence SEQ ID NO: 150 (AGATCCGTAACAAGTGTACCTGTGCATTCTG).

[0087] The reverse primer consists of two parts: a part of 20 nt homologous to the pRS426 vector sequence in the vicinity of the EcoRI restriction site and a part of 20 nt homologous to the 3' end of the HygroR cassette (SEQ ID NO: 143), the whole forming the sequence SEQ ID NO: 151 (TGGATCCCCCGGGCTGCAGGGGCAGTGCTAGTGTGTGTAC).

[0088] The PCRs carried out using the above primers gave rise to DNA fragments with homologous ends. A competent Saccharomyces cerevisiae strain W303 was transformed with these DNA fragments and also the digested pRS426 plasmid. The pRS426 plasmids containing the overexpression cassette for the TrAZF1 gene and the HygroR cassette were extracted from S. cerevisiae and used as template for PCR amplification of the overexpression cassette fused to the HygroR cassette (SEQ ID NO: 154) using the forward primer (SEQ ID NO: 152) and the reverse primer (SEQ ID NO: 153).

Example 3: Transformation of the T. reesei Strains RutC30 and C1847 with the TrAZF1 Overexpression Cassette

[0089] The T. reesei RutC30 (ATCC 56765) and C1847 strains were then transformed with the PCR product (SEQ ID NO 154) (Durand et al., 1988). The transformants were selected on the basis of the Hph selectable marker gene function. The transformants were purified from the colonies resulting from individual spores. The ectopic integration of the cassette was confirmed by three PCR amplifications. The position of the primers used and also the fragments amplified are indicated in FIG. 2. The primers used for the PCRs are described below:

TABLE-US-00002 Primers for verification amplification 1: A forward primer in the GPDp promoter (SEQ ID NO: 155): GTCAGAAACGACCAAGCTAAG. A reverse primer in the TrAZF1 gene (SEQ ID NO: 156): GCCTGAGAATGGTGTCGATC. Primers for verification amplification 2: A forward primer in the TrAZF1 gene (SEQ ID NO: 157): TCGTGGGCCTCAAGATTC. A reverse primer in the GPDt terminator (SEQ ID NO: 158): GACGCCTGAGAGGTCCTA. Primers for verification amplification 3: A forward primer in the GPDt terminator (SEQ ID NO: 159): CCTTCTTAGAGAGCTCTCGG. A reverse primer in the HygroR cassette (SEQ ID NO: 160): CGGGTTTACCTCTTCCAGAT.

[0090] The amplifications were carried out from the genomic DNA of the purified transformants: four transformants were selected for each strain.

Example 4: Culture of the T. reesei Strain RutC30 with the TrAZF1 Overexpression Cassette and Analysis of the Cultures for Protein Production

[0091] The spores originating from four transformants of the RutC30 strain which exhibit ectopic integration of the TrAZF1 overexpression cassette were used to inoculate a 24-well culture plate containing 2 ml of culture medium per well.

[0092] The medium was composed of K.sub.2HPO.sub.4 8.7 gl.sup.-1; (NH.sub.4).sub.2SO.sub.4 4.2 gl.sup.-1; MgSO.sub.4.7H.sub.2O 0.3 gl.sup.-1; cornsteep 1.5 gl.sup.-1; lactose 10 gl.sup.-1; cellulose 10 gl.sup.-1; maleic acid 11.6 gl.sup.-1; CaCl.sub.2) 0.3 gl.sup.-1; FeSO.sub.4.7H.sub.2O 5.0 mgl.sup.-1; MnSO.sub.4.H.sub.2O 1.6 mgl.sup.-1; ZnSO.sub.4.7H.sub.2O 1.4 mgl.sup.-1; CoCl.sub.2.6H.sub.2O 2.0 mgl.sup.-1; pH 6.

[0093] The culture was carried out at 30.degree. C. with shaking at 150 rpm, in duplicate.

[0094] After 7 days of culture, the supernatant was collected in order to measure the protein concentration in the medium (Folin method). The extracellular-protein production of the cultures is presented in FIG. 3. This figure shows an increase in the protein production for the transformants compared with the unmodified T. reesei strain.

Example 5: Culture of the T. reesei Strain C1847 with the TrAZF1 Overexpression Cassette and Analysis of the Cultures for Protein Production

[0095] The spores originating from four transformants of the C1847 strain which exhibit an ectopic integration of the TrAZF1 overexpression cassette were used to inoculate a 24-well culture plate containing 2 ml of culture medium per well.

[0096] The medium was composed of K.sub.2HPO.sub.4 8.7 gl.sup.-1; (NH.sub.4).sub.2SO.sub.4 4.2 gl.sup.-1; MgSO.sub.4.7H.sub.2O 0.3 gl.sup.-1; cornsteep 1.5 gl.sup.-1; lactose 10 gl.sup.-1; cellulose 10 gl.sup.-1; maleic acid 11.6 gl.sup.-1; CaCl.sub.2) 0.3 gl.sup.-1; FeSO.sub.4.7H.sub.2O 5.0 mgl.sup.-1; MnSO.sub.4.H.sub.2O 1.6 mgl.sup.-1; ZnSO.sub.4.7H.sub.2O 1.4 mgl.sup.-1; CoCl.sub.2.6H.sub.2O 2.0 mgl.sup.-1; pH 6.

[0097] The culture was carried out at 30.degree. C. with shaking at 150 rpm, in duplicate.

[0098] After 7 days of culture, the supernatant was collected in order to measure the protein concentration in the medium (Folin method). The extracellular-protein production of the cultures is presented in FIG. 4. This figure shows an increase in the protein production for the transformants compared with the unmodified T. reesei strain.

Example 6: Culture of the T. reesei Strain C1847 with Overexpressed AZF1 in Fed Flasks and Analysis of the Cultures for Protein Production and Growth

[0099] A culture of two transformants of the T. reesei strain C1847 and also of the non-transformed strain using the cellulase production method described in patent WO 2013/026964 A1. The extracellular-protein production and also the biomass were measured over time in order to obtain a measurement of the specific rate of protein production (protein production per mg of fungal biomass per unit of time, or qP) at the end of the culture. These values are presented in FIG. 5. The data show improved qP values in the mutants compared with the unmodified T. reesei strain.

LITERATURE

[0100] Durand, H., Clanet, M., & Tiraby, G. (1988). Genetic Improvement of Trichoderma reesei for large scale cellulase production. Enzyme and Microbial Technology, 10, 341-346.

[0101] Li, Junxin; Wang, Juan; Wang, Shaowen; Xing, Miao; Yu, Shaowen; Liu, Gang (2012) Achieving efficient protein expression in Trichoderma reesei by using strong constitutive promoters. In: Microbial cell factories, vol. 11, p. 84. DOI: 10.1186/1475-2859-11-84.

[0102] Poggi-Parodi, Dante; Bidard, Frederique; Pirayre, Aurelie; Portnoy, Thomas; Blugeon, Corinne; Seiboth, Bernhard et al. (2014) Kinetic transcriptome analysis reveals an essentially intact induction system in a cellulase hyper-producer Trichoderma reesei strain. In: Biotechnology for biofuels, vol. 7, n.degree. 1, p. 173. DOI: 10.1186/s13068-014-0173-z.

[0103] Schuster, Andre; Bruno, Kenneth S.; Collett, James R.; Baker, Scott E.; Seiboth, Bernhard; Kubicek, Christian P.; Schmoll, Monika (2012) A versatile toolkit for high throughput functional genomics with Trichoderma reesei. In: Biotechnology for biofuels, vol. 5, no 1, p. 1. DOI: 10.1186/1754-6834-5-1.

Sequence CWU 1

1

16011521DNAArtificial SequenceNucleotidic sequence of TrAZF1 gene of T.reesei 1atggccctcg cagctcaaca gcatactcag gccgattggg gccgctggtc tcaccagatt 60ccacagagtt ttcccatgat gggctctcca ggattcatgt catacgatcc cagagctcag 120gacggcagtc agatgcagcg tcaggtgtct gctcagtacc tggtgaactc gaactacaac 180cagcccccga tgcccactgc ttcgtctccc cagtatcaac acgcagggcc attttcctat 240gtgccttacc acagcccgcc gccgtccact cctcttggtt ccccattcaa gagcgaattt 300cccgagcacc ctcttacgcg catgacacac tctacggtcg atcgacacca ttctcaggcc 360atgagggact accaacctta ttctcctgta tcgaggaggg gatcgatttc ttcagtcgcc 420accaagccct cagcagctcc cgtcacacca ggtccaacta ctcctggctc tttcacttca 480agttccgacg cccagagccc cagcactcca aacccccaga ctgcgtctca gcctgtcagc 540tccaagactc tcacttacaa tgagaccgtt catccgggcg ataggatcag cttcagaacc 600gatgttgatg aactcatgaa ggccatccag aagacacaga cgaccgacga gtgtcagcaa 660acactcacac ctgcgcgaac accaaagaac tgtaccacaa gtactcccgt acttcgtaca 720caaagcggga agccgagaaa acagtgggtt tgcgatggcc ccaactgcgg caaggccttt 780gtccagaaga cgcatcgcga cattcaccga cgcactcaca ccggccatcg accatacgtc 840tgcaccatgg aaaattgcgg tcttacgttc tcgcagcgag gaaacctcaa gactcacata 900cgacgccaca caggtgaaaa gccgttctct tgcgctgctt gtggcaagtg cttcgctcag 960cgtgggaatc ttcgatccca cgaggagaca cacaaaggcc tgaagccctt cgtctgccgg 1020ctcgatgatt gcaacaagtc gttttctcag ctgggcaata tgaagactca tcagaacaac 1080tttcacaaag aaacgctcca gaaactcaca cacatgtttg tgcaattctc ggagaacggc 1140gaggtgccca gagactatca ggatcttttc gaatacttcc agaagcacta caagaatagc 1200aacaagggag tcaagggccg aggaaagact cgcgctgtgg cagctcgtgg gcctcaagat 1260tccgcgtttc ggcaggctgc ctccccagtg cccgcgttac tgaagacgcc ggctacgact 1320catttgcccc agatgacaat gccagcccat gatccccatg gcagaatctc accatacgcc 1380atgacccagg gagctgcgaa cactctgagc aatgtcctgc gcaaccccaa cccctcttac 1440ggcctttatg gacccacgtt tgccccgggc cctgtacgag atggcgtctt tcacatgggc 1500attgcgagcc acctatcctg a 15212506PRTArtificial SequenceTrAZF1 protein of T.reesei 2Met Ala Leu Ala Ala Gln Gln His Thr Gln Ala Asp Trp Gly Arg Trp1 5 10 15Ser His Gln Ile Pro Gln Ser Phe Pro Met Met Gly Ser Pro Gly Phe 20 25 30Met Ser Tyr Asp Pro Arg Ala Gln Asp Gly Ser Gln Met Gln Arg Gln 35 40 45Val Ser Ala Gln Tyr Leu Val Asn Ser Asn Tyr Asn Gln Pro Pro Met 50 55 60Pro Thr Ala Ser Ser Pro Gln Tyr Gln His Ala Gly Pro Phe Ser Tyr65 70 75 80Val Pro Tyr His Ser Pro Pro Pro Ser Thr Pro Leu Gly Ser Pro Phe 85 90 95Lys Ser Glu Phe Pro Glu His Pro Leu Thr Arg Met Thr His Ser Thr 100 105 110Val Asp Arg His His Ser Gln Ala Met Arg Asp Tyr Gln Pro Tyr Ser 115 120 125Pro Val Ser Arg Arg Gly Ser Ile Ser Ser Val Ala Thr Lys Pro Ser 130 135 140Ala Ala Pro Val Thr Pro Gly Pro Thr Thr Pro Gly Ser Phe Thr Ser145 150 155 160Ser Ser Asp Ala Gln Ser Pro Ser Thr Pro Asn Pro Gln Thr Ala Ser 165 170 175Gln Pro Val Ser Ser Lys Thr Leu Thr Tyr Asn Glu Thr Val His Pro 180 185 190Gly Asp Arg Ile Ser Phe Arg Thr Asp Val Asp Glu Leu Met Lys Ala 195 200 205Ile Gln Lys Thr Gln Thr Thr Asp Glu Cys Gln Gln Thr Leu Thr Pro 210 215 220Ala Arg Thr Pro Lys Asn Cys Thr Thr Ser Thr Pro Val Leu Arg Thr225 230 235 240Gln Ser Gly Lys Pro Arg Lys Gln Trp Val Cys Asp Gly Pro Asn Cys 245 250 255Gly Lys Ala Phe Val Gln Lys Thr His Arg Asp Ile His Arg Arg Thr 260 265 270His Thr Gly His Arg Pro Tyr Val Cys Thr Met Glu Asn Cys Gly Leu 275 280 285Thr Phe Ser Gln Arg Gly Asn Leu Lys Thr His Ile Arg Arg His Thr 290 295 300Gly Glu Lys Pro Phe Ser Cys Ala Ala Cys Gly Lys Cys Phe Ala Gln305 310 315 320Arg Gly Asn Leu Arg Ser His Glu Glu Thr His Lys Gly Leu Lys Pro 325 330 335Phe Val Cys Arg Leu Asp Asp Cys Asn Lys Ser Phe Ser Gln Leu Gly 340 345 350Asn Met Lys Thr His Gln Asn Asn Phe His Lys Glu Thr Leu Gln Lys 355 360 365Leu Thr His Met Phe Val Gln Phe Ser Glu Asn Gly Glu Val Pro Arg 370 375 380Asp Tyr Gln Asp Leu Phe Glu Tyr Phe Gln Lys His Tyr Lys Asn Ser385 390 395 400Asn Lys Gly Val Lys Gly Arg Gly Lys Thr Arg Ala Val Ala Ala Arg 405 410 415Gly Pro Gln Asp Ser Ala Phe Arg Gln Ala Ala Ser Pro Val Pro Ala 420 425 430Leu Leu Lys Thr Pro Ala Thr Thr His Leu Pro Gln Met Thr Met Pro 435 440 445Ala His Asp Pro His Gly Arg Ile Ser Pro Tyr Ala Met Thr Gln Gly 450 455 460Ala Ala Asn Thr Leu Ser Asn Val Leu Arg Asn Pro Asn Pro Ser Tyr465 470 475 480Gly Leu Tyr Gly Pro Thr Phe Ala Pro Gly Pro Val Arg Asp Gly Val 485 490 495Phe His Met Gly Ile Ala Ser His Leu Ser 500 50531699DNAArtificial SequenceGenomic nucleotidic sequence of TrAZF1 gene 3atggccctcg cagctcaaca gcatactcag gccgattggg gccgctggtc tcaccagatt 60ccacagagtt ttcccatgat gggctctcca ggattcatgt catacgatcc cagagctcag 120gacggcagtc agatgcagcg tcaggtgtct gctcagtacc tggtgaactc gaactacaac 180cagcccccga tgcccactgc ttcgtctccc cagtatcaac acgcagggcc attttcctat 240gtgccttacc acagcccgcc gccgtccact cctcttggtt ccccattcaa gagcgaattt 300cccgagcacc ctcttacgcg catgacacac tctacggtcg atcgacacca ttctcaggcc 360atgagggact accaacctta ttctcctgta tcgaggaggg gatcgatttc ttcagtcgcc 420accaagccct cagcagctcc cgtcacacca ggtccaacta ctcctggctc tttcacttca 480agttccgacg cccagagccc cagcactcca aacccccaga ctgcgtctca gcctgtcagc 540tccaagactc tcacttacaa tgagaccgtt catccgggcg ataggatcag cttcagaacc 600gatgttgatg aactcatgaa ggccatccag aagacacaga cgaccgacga gtgtcagcaa 660acactcacac ctgcgcgaac accaaagaac tgtaccacaa gtactcccgt acttcgtaca 720caaagcggga agccgagaaa acagtgggtt tgcgatggcc ccaactgcgg caaggccttt 780gtccagaaga cgcatcgcga cattcaccga cgcactcaca ccggccatcg accatacgta 840cgcgcccagc tcctcttcac tgcaacgccg gctaattaaa tgttgatagg tctgcaccat 900ggaaaattgc ggtcttacgt tctcgcagcg aggaaacctc aaggtaagct tcagctgcta 960agaatctcct ttgagaatgc gtatactgac cagatggtgt gtggacagac tcacatacga 1020cgccacacag gtgaaaagcc gttctcttgc gctgcttgtg gcaagtgctt cgctcagcgt 1080gggaatcttc gatcccacga ggagacacac aaaggcctga agcccttcgt ctgccggctc 1140gatgattgca acaagtcgtt ttctcagctg ggcaatatga aggtatgcaa catctagcac 1200atgaaagcag tatgagaacg ctctaacgct gagggaactg cagactcatc agaacaactt 1260tcacaaagaa acgctccaga aactcacaca catgtttgtg caattctcgg agaacggcga 1320ggtgcccaga gactatcagg atcttttcga atacttccag aagcactaca agaatagcaa 1380caagggagtc aagggccgag gaaagactcg cgctgtggca gctcgtgggc ctcaagattc 1440cgcgtttcgg caggctgcct ccccagtgcc cgcgttactg aagacgccgg ctacgactca 1500tttgccccag atgacaatgc cagcccatga tccccatggc agaatctcac catacgccat 1560gacccaggga gctgcgaaca ctctgagcaa tgtcctgcgc aaccccaacc cctcttacgg 1620cctttatgga cccacgtttg ccccgggccc tgtacgagat ggcgtctttc acatgggcat 1680tgcgagccac ctatcctga 169941437DNAArtificial Sequencegpd promoter 4gacgcagaag aaggaaatcg ccccgccggt tccgtaaaaa aaatatgagc gcagggacaa 60gcacagcctt ggccctgggc ctagccttgc gccttgtttg atgcaatcgg cgacatgtcg 120aatgctgtaa ttttttttgt ttaggttccc cttttccttt tgtgttaata ataattctcg 180aagggcgctg attttgaaat ttgtcggtga gagccaaacg gatatacagg cgcggctgat 240gaataatgat gaatcgagct gacttgatgc tgtatgtaca atattgactg cgaggaccat 300caggtgttgt atggatggaa tcattctgta accaccaagg tgcatgcatc ataaggtatt 360ctcctcagct caccaacaac gaacgatggc catgttagta aaggcaccgt gatggcaaga 420tagaaccact attgcatctg cgcttcccac gcacagtacg tcaatgtaac gtcaaagccg 480ccctcccgta acctcgcccg ttgttgctcc ccccgattgc ctcaatcaca tagtacctac 540ctatgcatta tggcgcctca acccaccccc ccagattgag agctacctta catcaatatg 600gccagcacct cttcggcgat acatactcgc caccccagcc ggggcgattg tgtgtactag 660gtaggctcgt actataccag caggagaggt gctgcttggc aatcgtgctc agctgttagg 720ttgtacttgt atggtacttg taaggtggtc atgcagttgc taaggtacct agggagggat 780tcaacgagcc ctgcttccaa tgtccatctg gataggatgg cggctggcgg ggccgaagct 840gggaactcgc caacagtcat atgtaatagc tcaagttgat gataccgttt tgccaggatt 900aggatgcgag aagcagcatg aatgtcgctc atccgatgcc gcatcaccgt tgtgtcagaa 960acgaccaagc taagcaacta aggtacctta ccgtccacta tctcaggtaa ccaggtacta 1020ccagctaccc tacctgccgt gcctacctgc tttagtatta atctttccac ctccctcctc 1080aatcttcttt tccctcctct cctctttttt ttttcttcct cctcttcttc tccataacca 1140ttcctaacaa catcgacatt ctctcctaat caccagcctc gcaaatcctc aggttagtat 1200tactactact acaatcatca ccacgatgct ccgcccgacg atgcggcttc tgttcgcctg 1260cccctcctct cactcgtgcc cttgacgagc taccccgcca gactctcctg cgtcaccaat 1320ttttttccct atttacccct cctccctctc tccctctcgt ttcttcctaa caaacaacca 1380ccaccaaaat ctctttggaa gctcacgact cacgcaagct caattcgcag atacaaa 14375645DNAArtificial Sequencegpd terminator 5tctagaaaga aggattacct ctaaacaagt gtacctgtgc attctgggta aacgactcat 60aggagagttg taaaaaagtt tcggccggcg tattgggtgt tacggagcat tcactaggca 120accatgcatc cttactattg tataccatct tagtaggaat gatttcgagg tttataccta 180cgatgaatgt gtgtcctgta ggcttgagag ttcaaggaag aaacatgcaa ttatctttgc 240gaacccaggg ctggtgacgg aattttcata gtcaagctat cagagtaaag aagaggagca 300tgtcaaagta caattagaga caaatatata gtcgcgtgga gccaagagcg gattcctcag 360tctcgtaggt ctcttgacga ccgttgatct gcttgatctc gtctcccgaa aatgaaaata 420gctctgctaa gctattcttc tcttcgccgg agcctgaagg cgttactagg ttgcagtcaa 480tgcattaatg cattgcagat gagctgtatc tggaagaggt aaacccgaaa acgcgtttta 540ttcttgttga catggagcta ttaaatcact agaaggcact ctttgctgct tggacaaatg 600aacgtatctt atcgagatcc tgaacaccat ttgtctcaac tccgg 6456475PRTArtificial Sequencesynthesized 6Met Glu Thr Ala Val Pro Val Ala Tyr Asn Val Thr Asn His Asp Met1 5 10 15Asn Ala Val Ala His Arg Arg Met Met Ala Pro His Gln Gln His His 20 25 30His His His His His His Asp Gln Asn Ile Ala Tyr Phe Ser Asn Pro 35 40 45Pro Ile Pro Tyr Ser Thr Pro Leu Gln Pro Pro Ser Phe Gly Gly Phe 50 55 60Gly His Ile Leu Asn Asn His Pro His His Thr Ser Tyr Gln Gly Tyr65 70 75 80Phe Asn Ser Asn Pro Asn Pro Asn Pro Gln Val Asn Ser His His His 85 90 95Arg Leu Ala Thr Glu Thr Asn Pro Val His Gln Val Ser Asp Ile Arg 100 105 110His Val Lys Asn Pro Asn Gln Arg Leu Ile Arg Pro Ser Pro Pro Lys 115 120 125Glu Asp Thr Leu Pro Pro Ala Pro Ala Pro Ala Pro Ala Val Ala Pro 130 135 140Pro Pro Pro Pro Arg Leu Pro Pro Gln Arg Val Ser Val Ala Pro Val145 150 155 160Arg Asn Thr Thr Gln His Glu Asp Ser Lys Pro Met Pro Lys Pro Gly 165 170 175Val Glu Phe Gly Thr Glu Val Asp Thr Leu Met Lys Ala Ile Gln Ser 180 185 190Lys Pro Gln Pro Ala Ser Pro Gln Val Glu His Gln Leu Pro Pro Leu 195 200 205His Gln Lys Phe Asn Asn Gly Val Ala Asn Trp Ile His Pro Ala Tyr 210 215 220Ala Asn Gln Met Ala Gly Asn Gln Ala Ile Phe Pro Asn Ala Pro Gln225 230 235 240Asp Arg Val Pro Pro Pro Asn Gln Lys Ala Lys Arg Lys Tyr Glu Cys 245 250 255Thr Leu Pro His Cys Arg Lys Ser Phe Phe Gln Lys Thr His Leu Asp 260 265 270Ile His Met Arg Ala His Thr Gly Asp Lys Pro Phe Thr Cys Lys Glu 275 280 285Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu Lys Thr His 290 295 300Glu Arg Arg His Thr Gly Glu Lys Pro Tyr Ser Cys Glu Ile Cys His305 310 315 320Lys Lys Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Thr His 325 330 335Glu Gln Ala Lys Pro Phe Lys Cys Gln Leu Asp Asp Cys Gly Lys Gln 340 345 350Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala 355 360 365Gln Thr Leu Arg Asn Leu Thr Leu Arg Phe Ala Ser Ile Gly Asp Ile 370 375 380Asp Arg Met Ser Pro Gln Asp Lys Glu Leu Trp Ser Tyr Phe Ser Thr385 390 395 400Leu Tyr Arg Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg 405 410 415Arg Val Ser Thr Ala Lys Thr Ser Thr Ser Ala Tyr Asp Gly Ser His 420 425 430Ser Glu Ser Glu Gly Glu Ala Lys Gly Arg Ser Arg Ser Tyr Asp Arg 435 440 445Ala Ser Ala Val Met Thr Ser Ser Ser Asp Glu Pro Asp Tyr Arg Glu 450 455 460Gln Leu Tyr His His Arg Asn Gly Ala His His465 470 4757389PRTArtificial Sequencesynthesized 7Met Asp Ile Val Asn Ile Leu Asn Lys Lys Glu Ala Ser Ala Ser Ser1 5 10 15Asp Asn Ala Val Ser Pro Thr Ser Arg Gln Pro Glu Thr Gly Gln Ala 20 25 30Arg Phe Glu Lys Gln Asp Ala Val Arg Leu Pro Ser Met Ala Pro Asn 35 40 45Ser Phe Ser Thr Tyr Pro His Ala Thr Phe Ala Pro Arg Tyr Ser Tyr 50 55 60Glu Thr Gln His Ser Pro Pro Pro Ala Ala Ser Pro Ser Asn Pro Phe65 70 75 80Ala Thr Ser Pro Gly Pro Ser Ser Glu Gly Pro His Ser Asn Asn Gly 85 90 95Asn Asp Asp Pro Thr Lys Pro Tyr His Cys Lys Thr Cys Ser Lys Gly 100 105 110Phe Ala Arg Arg Ser Asp Leu Ser Arg His Glu Arg Ile His Ser Gly 115 120 125Ile Arg Pro His Ile Cys Asp Phe Glu Gly Cys Gly Lys Gln Phe Ile 130 135 140Gln Arg Ser Ala Leu Thr Val His Ala Arg Val His Thr Gly Glu Lys145 150 155 160Pro His Met Cys Glu Ala Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 165 170 175Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 180 185 190Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr 195 200 205Arg His Gln Asn His His Thr Gly Thr Ile Ser Glu Ala Ala Ala Ala 210 215 220Thr Ala Ala Ala Leu Ala Ser Arg Arg Ser Ser Ser Lys Ser Ser Val225 230 235 240Gln Ser Leu Ser Leu Thr Gly Asn Ser Pro Arg Glu Asp Asn Met Glu 245 250 255Ser Val Ser Gln Ser Arg Thr Gly Ser Asn Ser Ser Leu Arg Leu Ser 260 265 270Gln Gly Ser Ser Pro Ala Ala Asp Leu Asp Lys Gln Val Ile Leu Ala 275 280 285Trp Arg Glu Ser Pro Pro Tyr Gln Ala Val Thr Ser Leu Pro Thr Pro 290 295 300Val Ser Thr Pro Thr Ile Pro Ala Asn Leu Val Thr Gly Thr Ala Ala305 310 315 320Leu Gln Ile Ser Asp Ser Arg Gln Asn Leu Arg Gly Leu Pro Pro Leu 325 330 335Gly Ser Gly Ser Gln Pro Arg Ser Leu Ser Pro Leu His Arg Ser Pro 340 345 350Ser Ser Gly Ile Ser His His Ile Trp Gln His His Thr His Asn Gly 355 360 365Ser Pro Thr Ser Leu Leu Pro Ile His Thr Ala Ile Ser Leu Ser Pro 370 375 380Gln Pro Ala Tyr Arg3858482PRTArtificial Sequencesynthesized 8Met Ala Ala Arg Pro Phe Gln Cys Glu Trp Pro Glu Gly Cys Ser Lys1 5 10 15Ser Phe Asn Arg Lys Ser Asp Leu Gln Arg His Tyr Arg Ile His Thr 20 25 30Asn Glu Arg Pro Tyr Ala Cys Asp Tyr Lys Pro Cys Thr Lys Thr Phe 35 40 45Ile Gln Arg Ser Ala Leu Thr Val His Arg Arg Thr His Thr Gly Asp 50 55 60Lys Pro His Lys Cys Pro Phe Leu Gly Cys Gly Lys Cys Phe Ser Asp65 70 75 80Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Asn Asp Lys Pro 85 90 95Tyr Ile Cys Arg Asn Gln Arg Cys Lys Lys Ala Phe Cys Arg Lys Thr 100 105 110Thr Met Thr Lys His Ile Arg Lys Glu His Pro Ala Glu Pro Ile Gln 115 120 125Glu Asp Gln Asp Ala Glu Tyr Ser Asp Val Asp Pro Ser Asp Asp Glu 130 135 140Val Leu Glu Asp Asp Ile Asp Glu Ile Lys Glu Glu Ala Gly Ser Pro145 150 155 160Tyr Gln Glu Asp Pro Lys Asp Ser Arg Leu Thr

Arg Pro Leu Ser Asn 165 170 175Tyr His Ala Asn Leu Trp Pro Leu Pro Ala Gln Thr Ala Gln Arg Pro 180 185 190Thr Leu His Arg Ser Glu Ser Ser Ser His Asp Ile Lys Leu Glu Arg 195 200 205Thr Ser Ser Gly Thr Pro Gln Arg Ser Leu Thr Asp Pro Tyr Pro Asp 210 215 220Ser Ser Ile His Ser Ala Gly Leu Asn Gly Val Thr Ile His Ser Val225 230 235 240Met Pro His Gly Leu Asn Thr Ser Asn Met Pro Gln Gln Phe Gln Tyr 245 250 255Arg Ser His Asp Asn Asn Val Gly Leu Trp Ser Pro Gly His Asp Ser 260 265 270Pro Thr Ser Ile Thr Asn Ser Ser Pro Ser Ser Val Ser Ala Gln Thr 275 280 285His Pro Ile Tyr Thr Ser Gln Pro Tyr Gln Leu Gln Pro Asn Ser Leu 290 295 300Pro Thr His Ala Gln Ile Gln Tyr Ser His Asp Gly Met Val Ser Asn305 310 315 320Ile Gln Gln Pro Met Asn Asp Leu Ala Val His Asp Ile His Leu Asp 325 330 335Gln Pro Gln Gln His Gln Tyr His Asp Met Ala Ser Thr Pro Ile Gln 340 345 350Gln Gln Gln Gln Tyr Glu Gly Val Pro Gln Gln Val Ser Pro Gln Asp 355 360 365His Tyr Ile Glu Met Ser Arg Asp Pro Pro Gln His Pro Ala Tyr Ala 370 375 380Glu Gly Pro Pro Gln Ala Ala Val His His Phe Gln Ser Glu Val Pro385 390 395 400Pro Thr Pro Ala Thr Asn Arg Asp Leu Ser Arg Tyr Ala Thr Ser Ile 405 410 415Pro Gln Glu Gln Thr Tyr Gln Gln Pro Gln Leu Leu Pro Ile Glu Glu 420 425 430Thr Phe Ser Ile Gly His Gln Tyr Phe Leu Pro Asn His Gly Ser Tyr 435 440 445Gln Ile Asn Gln Pro Ser Tyr Phe Phe Asp Glu Leu Lys Asp Lys Pro 450 455 460Asp Thr Met Trp Ala Gly Pro Leu Pro Asp Gln Arg Leu Lys Asp Glu465 470 475 480Trp Pro9397PRTArtificial Sequencesynthesized 9Met Ala Gly Val Met Ser Ser Phe Asn Met Ala Phe Gln Pro Asp Thr1 5 10 15Ser Ala Ile Leu Pro Tyr Met Gln Met Gln Glu Gln Glu Arg His Thr 20 25 30Met His Ala Pro Ser Ile Ile Pro Ser Asp Leu Met Asn Thr Gln Ile 35 40 45Asn Ala Asp Leu Ser Val Gly Leu Gly Met Asp Ala Ser Phe Ala Asn 50 55 60Ala His Ala Met Asn Val Asp Tyr Asn Asn Ala Thr Phe Gly Asn Leu65 70 75 80Ala Ala Trp Pro Ala Pro Ile Asn Thr Asn Phe Asn Ala Met Pro Arg 85 90 95Pro Val Met Met Gln Ala Glu Ser Tyr Ser Ser Thr Asp Ser Ser Glu 100 105 110Pro Tyr Ile Lys Thr Glu Asp Asp Ser Pro Val His Ala Ser Gln Val 115 120 125Phe Tyr Asn Ala Asn Ala Tyr Ala Ser Ser Pro Glu Ser Gln Thr Gly 130 135 140Thr Asp Glu Pro Glu Glu Thr Lys Pro Thr Val Phe Ala Thr Asp Ile145 150 155 160Asp Thr Leu Met Arg Ala Ile Gln Thr Lys Thr Gly Ser Ala Ala Glu 165 170 175Gln Arg Gln Lys Asp Gln Thr Glu Val Thr Ile Thr Glu Ile Ser Pro 180 185 190Val Lys Pro Lys Lys Arg Tyr Glu Cys Asn Val Pro Asp Cys Gly Lys 195 200 205Ala Phe Tyr Gln Lys Thr His Leu Glu Ile His Thr Arg Ala His Thr 210 215 220Gly Ile Lys Pro Phe Leu Cys Arg Glu Pro Ser Cys Gly Gln Arg Phe225 230 235 240Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly Glu 245 250 255Arg Pro Tyr His Cys Asp Ile Cys Gly Lys Thr Phe Ala Gln His Gly 260 265 270Asn Val Arg Ala His Lys Ile Val His Thr Ala Ala Lys Pro Phe Thr 275 280 285Cys Lys Leu Asp Ser Cys Asn Lys Gln Phe Thr Gln Leu Gly Asn Leu 290 295 300Lys Ser His Gln Asn Lys Phe His Ile Glu Thr Ile Arg Arg Leu Lys305 310 315 320Ser Arg Phe Glu Ser Phe Arg Glu Gly Asp Val Val Asp Thr Trp Glu 325 330 335Lys Glu Met Trp Glu Tyr Phe Ala Ser Leu Tyr Lys Asn Cys Asn Lys 340 345 350Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Ile Ser Asn Thr Ala Ala 355 360 365Ala Gln Arg Arg Asn Ser Ile Val Ser Ser Val Gly Ser Ser Ser Gly 370 375 380Ser Met Ser Ala Gly His Ser Val Pro Gln Arg Thr Tyr385 390 39510434PRTArtificial Sequencesynthesized 10Met Glu Leu Met Glu Leu Val Glu Asn Glu Pro Thr Val Arg Pro Phe1 5 10 15Gln Cys Glu Trp Pro Ser Cys Gln Lys Asn Phe Asn Arg Lys Ser Asp 20 25 30Leu Gln Arg His Phe Arg Ile His Thr Asn Glu Arg Pro Tyr Ser Cys 35 40 45Leu Thr Pro Gly Cys Asn Lys Ser Phe Ile Gln Arg Ser Ala Leu Thr 50 55 60Val His Ile Arg Thr His Thr Gly Glu Lys Pro His Gln Cys Gln Gln65 70 75 80Leu Glu Cys Gly Lys Arg Phe Ser Asp Ser Ser Ser Leu Ala Arg His 85 90 95Arg Arg Ile His Thr Gly Lys Arg Pro Tyr Lys Cys Ala His Glu Gly 100 105 110Cys Leu Lys Ser Phe Cys Arg Lys Thr Thr Met Val Lys His Gln Arg 115 120 125Arg Ser His Gln Arg Gly Gly Gly Val Asn Ser Ser Glu Leu Glu Asp 130 135 140Gly Asp Thr Ser Asp Ser Asp Met Gly Glu Ser Pro Ser Thr Pro Gln145 150 155 160Leu Val Met Gln Ala His Trp Pro Gln Asp Leu Asn Thr Val Ile Thr 165 170 175His Ser Val Met Gln Ser His His Gln Ala Thr His Arg Ser Gln Ser 180 185 190Phe Ala Asp Phe Gly His Tyr His Asn Ala Asn Ser Gln Pro Tyr Val 195 200 205Thr Thr Asp Val Tyr Pro Pro Arg His Ser Leu Ser Glu Ser Pro Gln 210 215 220His Tyr Gln His Arg Ser Leu Ser Leu Gln Asp Gln Arg His Pro Gln225 230 235 240Asp Leu Ile Gln Gln Gln Gln Arg Gln His Gln His Pro Tyr Phe Ile 245 250 255Pro Glu Gln Asn Asn Pro Gly Val Ala Thr Met Asn Thr Asn Pro Asn 260 265 270Ser His Ile Gln Thr Tyr Ile Ala Arg Gln Ile Pro Asp Leu Gln Ile 275 280 285Pro Asp Leu Gln Ile Pro Tyr Thr Thr Gln Pro Leu Pro Ala Ser Val 290 295 300Tyr Ala Gly Ser Asp Thr Tyr Ser Ala Leu Ser Ala Arg Thr Pro Pro305 310 315 320Pro Pro Glu Leu Tyr Tyr Ala His Gln Gln Pro Ile Gln Lys Phe Glu 325 330 335Tyr Pro Ala His Gln Pro Ser Pro Ile Asp Gln Gln Gln Gln His Gln 340 345 350Gln Val Pro Val Val Gln Tyr Gln Arg Leu Gln Val Gln Gln Val Val 355 360 365Pro Thr Pro Gln Gln Gln Gln Gln Tyr Gln Thr Pro Gln Glu Gln Trp 370 375 380Tyr Ala Gln Ala Pro Phe Gln Glu Pro Val Glu Leu Ala Ser Ala Ile385 390 395 400Asn Ser Tyr Thr Ser Ala Gly Leu Asn Asp Pro Trp Gln Leu Lys Met 405 410 415Glu Ala Phe Glu Asp Pro Ser Met Gln Leu Pro Ser Ala Arg Cys Glu 420 425 430Asn Leu11471PRTArtificial Sequencesynthesized 11Met Met Ala Ser Pro His Met Leu Pro Phe Asp Ser Arg Ala Thr Thr1 5 10 15Thr Gly Pro Leu Gln Arg Pro Val Met Ala Pro Tyr Met Val His Pro 20 25 30Pro Tyr Ser Ser Gly Pro Val Asn Ser Leu Thr Ala Pro His Tyr Gln 35 40 45Val Pro Asn Pro Tyr Gln Phe Gly Gly Tyr Gln Gly Pro Pro Thr Pro 50 55 60Pro His His Ser Thr Pro Phe Lys Met Glu Tyr Asn Asp Arg Arg Pro65 70 75 80Met Gly His Asp Asn Asp His Gly Arg Met Pro Ser Tyr Ser Arg Glu 85 90 95Met Lys Tyr Thr Tyr Ala Glu Gln Ala Pro Ser Pro Ala Arg Ser Asp 100 105 110Ser Gln Ala Ser Thr Val Arg Ser Ser Gly Thr Asn Pro Ser Met Gly 115 120 125Ser Lys Thr Ile Thr Ser Asn Glu Thr Leu Asn Pro Gly Asp Gln Ile 130 135 140Asn Phe Glu Thr Glu Val Asp Glu Leu Met Lys Ala Ile Gln Arg Lys145 150 155 160Val Asp Leu Gln Val Asp Thr Val Gln Gln Pro Leu Thr Pro Gly Met 165 170 175Ser Pro Val Ser Glu Ala Ser Phe Glu Ser Gln Gly Thr Pro Gly Pro 180 185 190Met Asp Ser Lys Thr Ala Arg Lys Arg Tyr Arg Cys Asp Gly Pro Asn 195 200 205Cys Gln Lys Ser Phe Thr Gln Lys Thr His Leu Asp Ile His Arg Arg 210 215 220Thr His Thr Gly Ile Lys Pro Tyr Asn Cys Asp Phe Pro Gly Cys Asp225 230 235 240Leu Thr Phe Ser Gln Leu Gly Asn Leu Lys Thr His Arg Arg Arg His 245 250 255Thr Gly Glu Arg Pro Phe Ala Cys Asp Lys Cys Asp Arg His Phe Ala 260 265 270Gln Arg Gly Asn Leu Arg Ala His Leu Gln Thr His Gln Gly Leu Lys 275 280 285Pro Phe Ile Cys Ile Leu Asp Asp Cys Asn Lys Thr Phe Ser Gln Leu 290 295 300Gly Asn Met Lys Thr His Gln Asn Asn Phe His Lys Lys Thr Leu Lys305 310 315 320Lys Leu Thr Met Lys Phe Ala Asn Ile Ile Ala Ser Gly Glu Glu Val 325 330 335Ser Glu Ala Asp Arg Glu Leu Phe Glu Tyr Phe Ala Ala His Tyr Lys 340 345 350Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Ala Arg Thr Val Ala 355 360 365Asp Arg Lys Ala Lys Thr Ser Gln Ser Pro Pro Ala Asn Thr Met Thr 370 375 380Ala Val Pro Gln Tyr Pro Leu Pro Gln Ile Ala Pro Thr Pro Val Thr385 390 395 400Pro His Gly Leu Pro Val Ser Gly Ser Leu Ala Ser Tyr Ser Val Thr 405 410 415Arg Gly Gln Pro Gly Pro Ile Asn His Met Ser Arg Gln Thr His Thr 420 425 430Gly Gly Tyr Glu Val Tyr Asp Ile Gln Gly His His His Ile Gln Pro 435 440 445Pro Asn Asn Asn Gly Met Leu Tyr Glu Thr Gly Ser Thr Arg Glu Met 450 455 460Gly Tyr His Gly Arg Met Tyr465 47012413PRTArtificial Sequencesynthesized 12Met Asp Val Ser Ala Ile Thr Asn His Asp Thr Ala Asn Thr Glu Pro1 5 10 15Gly Ala Ala Lys Glu Thr Glu Leu Lys Gln Ser Gln Asp His Ala Phe 20 25 30Ser Ile Ser Ser Met Met Asn Asn Asp Glu Glu Arg Thr Val Ser Pro 35 40 45Asp Pro Ile Gln Thr Glu Glu Arg Glu Gln Glu Asn Gly Lys Glu Glu 50 55 60Asn Gly Ile His His Ser Asp Ser Gln Asn Asp Leu Val Pro Lys Asp65 70 75 80Val Asp Ala Gly Ser Glu Ser Thr Leu Ser Asp Val Glu Ser Thr Lys 85 90 95Ala Gln Ser Glu Asp Glu Phe Thr Asp Leu Glu Leu Ser Asp Asp Asn 100 105 110Ala Glu Glu Ile Glu Ser Lys Arg Ile Glu Ala Asp Cys His Trp Ser 115 120 125Gly Cys Gln Asp Lys Phe Leu Asn Ile Asp Asp Leu Val Gln His Leu 130 135 140Asn Ser Lys His Ile Thr Asn Val Asp Ser Val Tyr Arg Cys Glu Trp145 150 155 160Asp Asn Cys Phe Arg Lys Gly Val Thr Gln Pro Ser Arg Phe Ala Leu 165 170 175Ile Ser His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Phe Cys Ile 180 185 190Ile Pro Glu Cys Ser Lys His Phe Thr Arg Ala Asp Ala Leu Ser Gln 195 200 205His Ile Arg Thr Val His Gln Thr Ser Asn Leu Ser Val Glu Tyr Pro 210 215 220Phe Trp Tyr Ser Tyr Leu Asn Gly Leu Lys Asn Asp Glu Thr Phe Ala225 230 235 240Lys Arg Phe Arg Leu Met Pro Glu Met His Ser Leu Glu Arg Tyr Ser 245 250 255Lys Leu Asp Ser Gly Asp Gln Phe Gln Lys Glu Leu Ala Asn Lys Lys 260 265 270Ile Gln Phe Asp Asn Ile His Asn Ile Glu Leu Thr Asp Leu Thr Glu 275 280 285Pro Thr Ser Lys Arg Gln Lys Thr Ser Leu Lys Asp Ile Asn Ala Gly 290 295 300Leu Lys Ala Ser Phe Glu Lys Glu Asp Ala Asp Phe Lys His His Ile305 310 315 320Ala Ala Ala Ala Lys Asp Thr Phe Lys Ser Leu Glu Gly Val Glu Ser 325 330 335Leu Pro Thr Asp Ala Ser Ile Glu Ser Val Gln Ser Leu Glu Glu Leu 340 345 350Gln Ala Leu His Glu Ser Leu Arg Arg Lys Tyr Val Trp Gly Leu Glu 355 360 365Val Glu Lys Leu Ile Thr Lys Glu Leu Lys Gln Leu Arg Thr Glu Lys 370 375 380Thr Gln Leu Trp Leu Lys Lys Glu Thr Leu Leu Asp Ala His Ile Glu385 390 395 400Leu Glu Ile Ser Glu Asn Arg Asp Leu Tyr Ser Leu Lys 405 41013373PRTArtificial Sequencesynthesized 13Met Arg Tyr Pro Pro His Gly Gln Pro Ser Ser Gly Met Arg Ile Leu1 5 10 15Gln Asn Pro Tyr Val Pro Gly Ala Tyr Thr Gly Ser Ala Gln Ile Pro 20 25 30Gly Gly Ala Thr Pro Gln Arg Ala Asp Pro Pro Pro Lys Thr Phe His 35 40 45Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg 50 55 60His Glu Arg Ile His Thr Gly Ile Arg Pro His Ala Cys Asp Trp Pro65 70 75 80Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser 85 90 95Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys 100 105 110Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser 115 120 125Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe 130 135 140Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr145 150 155 160Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala Asn Leu Arg Gln Asn Lys 165 170 175Glu Arg Val Arg Ala Pro Gly Asp Gly Gly Phe Ser Glu His Ala Ser 180 185 190Val His Ser Thr Pro Ser Pro Ala His His Pro Val Ser Ile Pro Pro 195 200 205Pro Gly Asp Leu Pro Pro Leu Asn Met Pro Arg Ser Ala Gly Asp Tyr 210 215 220Tyr Met Gly Asn Gly Ser Ile Pro Pro His Val Arg Gly Asp Phe Ser225 230 235 240Gln Ala Ser Pro Arg Ser Ser Pro Thr Ala Thr Ser Pro Ser Leu Ser 245 250 255Ser Phe Ser Gly Ala Pro His Gln Arg Pro Ser Met Thr Ser His Pro 260 265 270Ser Gly Tyr Ala Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Ser Asp 275 280 285His Arg Pro Asn Ser Val Ser Gly Ser Pro His Met Thr Ser Leu Gly 290 295 300Trp Ala Ser Pro Ser His Gly Ser Ile Pro Ser Pro Gly Ser Val Asn305 310 315 320Asp Phe Asn Tyr Pro Glu Pro Ser Gly Pro Ala Tyr Pro Ser Ser Met 325 330 335Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile Arg Arg Pro Thr Ser 340 345 350Thr Glu Pro Glu Asn Tyr Glu Leu Lys Pro Arg Leu Gly Asp Asn Gly 355 360 365Trp Ser Thr Pro Val 37014435PRTArtificial Sequencesynthesized 14Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Val Val1 5 10 15Ala Ala Glu Val Gln Gln Leu Gln Gln His Leu Ala Gln Ala Gln Ala 20 25 30Ala Asp Asp Ala Lys Ser Arg Ser Pro Ser Glu Met Gly Ser Glu His 35 40

45Gly Ser Ala Ser Ala Pro Pro Ser Glu His Gln Gln Thr Tyr Pro Ser 50 55 60Ser Thr Gln Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val65 70 75 80Gln Ala Gln Ala Thr His Asn Asn Tyr Ala His Ser Ala His Gly Ser 85 90 95Asp Tyr Gly Arg Asn Gly Ser Gly Asn Met Arg Pro Ser Gly Leu Pro 100 105 110Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly Phe Ala Arg 115 120 125Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro 130 135 140His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser145 150 155 160Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro His Met 165 170 175Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 180 185 190His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 195 200 205Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln 210 215 220Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala225 230 235 240Asn Leu Arg His Ser Lys Asp Arg Val Ser Arg Pro Ser Asp Tyr Ser 245 250 255Glu Ala Gly Ser Ala His Ser Thr Pro Ser Pro Ala Gln Arg Pro Ser 260 265 270Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn Leu Ser Arg Pro Ser 275 280 285Gly Asp Tyr Tyr Thr Ser Leu Pro Pro His Leu Arg Thr Asp Phe Gln 290 295 300Gln Ser Ser Pro Arg Ala Ser Pro Thr Ser Pro Ser Pro Thr Leu Thr305 310 315 320Ser Leu Ser Gly Pro Ala Ser Tyr His Asn Arg Pro Ser Leu Thr Ser 325 330 335His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn 340 345 350Ser Asp Pro Arg Pro Asn Ser Val Ala Gly Ser Pro His Leu Ser Ser 355 360 365Val Gly Trp Ala Ser Pro Thr Leu Ser Ser Met Pro Ser Pro Ser Ser 370 375 380Ala Ser Ala Pro Glu Tyr Ser Tyr Pro Glu Pro Ser Ser His Gln Tyr385 390 395 400Pro Gly Gly Ile Thr Pro His Met Phe Phe Ser Gly Gln Gly Leu Arg 405 410 415Arg Pro Gln Ser Ser Glu Pro Glu Asn Tyr Glu Met Lys Pro Lys Leu 420 425 430Glu Met Ser 43515436PRTArtificial Sequencesynthesized 15Met Ser Gly Met Arg Ser Pro Ala Pro Thr Glu Val Met Asp Ile Thr1 5 10 15Asn Met Leu Asn Lys Lys Gly Gln Met Gln Gln Leu Thr Ser Gly Leu 20 25 30Leu Asp His Gln Gln Tyr Gln His Ala Phe Val Lys His Glu Pro Gly 35 40 45Met Glu Arg Ser Ala Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser 50 55 60Asn Pro His Ser Ile Ala Arg Ala Tyr Pro Ser Pro Ser Thr Met Gln65 70 75 80Ala Pro Met His Met Pro Asn Pro Met Ser Ala Ala Met Thr Ile Gln 85 90 95Gly Tyr Pro Glu Met Pro Asn Met Gly Gly Met Pro His Met His Met 100 105 110Gln Gln Met Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Ile Lys 115 120 125Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp 130 135 140Leu Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro His Val Cys145 150 155 160Asp Trp Pro Gln Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr 165 170 175Val His Gln Arg Val His Thr Gly Glu Lys Pro His His Cys Glu Thr 180 185 190Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg 195 200 205Thr His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln 210 215 220Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His225 230 235 240Ser Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala 245 250 255Ala Ser Lys Ser Lys Gly Leu Ser Gln Ala Arg Ser Glu Ser Asp His 260 265 270Met Ser Asn His Gly Ser Pro Leu Thr Thr Pro Ser Pro Ser Gln Arg 275 280 285Thr Met Ser Met Ser Pro Ser Val Asp Leu Ser Gly Asn Asn Ser Ile 290 295 300Pro Arg His Pro Gly Asp Phe Gln Tyr Leu Ser Gln Asn Gly Ser Leu305 310 315 320Pro Met His Met Arg Val Gly Ser Pro Thr Ser Thr Ser Ser Gly Gly 325 330 335Tyr Asn Met Met Arg Pro Thr Ser His Pro Thr Ser Tyr Gly Pro Pro 340 345 350Pro Thr Leu Glu Pro Asn Leu Asp Asn Ser Gln Gly Thr Pro Ser Ser 355 360 365Asn Gly Gly Ser Pro His Met Ala Asn Val Gly Trp Gln Ser Pro Ser 370 375 380His Met Ala Ser Pro Ser Gln Asn Asn Ala Ser Tyr Val Tyr Pro Asp385 390 395 400Pro Ala Asp Ala Tyr Pro Ala Asn Gln Ala Met Asn Gln Met Tyr Tyr 405 410 415Ser Ala Ala Thr His Met Arg Arg Pro Gln Ser Thr Glu Pro Gly Leu 420 425 430Val His Met Ala 43516445PRTArtificial Sequencesynthesized 16Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Ile Val1 5 10 15Ala Ala Asp Val His Gln Leu Gln Gln His Leu Ala Gln Ala Pro Val 20 25 30Thr Val Thr Val Ala Val Thr Ser Arg Ser Pro Ser Glu Leu Gly Ala 35 40 45Ser Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His His His 50 55 60His His His His His Gln Pro Thr Ser Ser Phe Pro Ser Ser Thr Gln65 70 75 80Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val Gln Ala Gln 85 90 95Ala Asn His Ala Gly Thr Ser Gln Gly Tyr Ala His Ser Ala His Gly 100 105 110Ser Asp Tyr Gly Arg Ser Thr Thr Ser Met Arg Pro Thr Gly Leu Pro 115 120 125Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly Phe Ala Arg 130 135 140Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro145 150 155 160His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser 165 170 175Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro His Met 180 185 190Cys Asp Arg Cys Gly Lys Pro Phe Ser Glu Ser Ser Ser Leu Ala Arg 195 200 205His Cys Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 210 215 220Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln225 230 235 240Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala 245 250 255Asn Leu Arg His Ser Lys Asp Arg Ser Thr Thr Ser Arg Pro Ser Asp 260 265 270Ala Leu Leu Ser Pro Leu Asn Leu Ser Ser Arg Pro Thr Ser Gly Trp 275 280 285Arg Pro Leu Leu Ser Ala Gly Gly Ala Ala Asp Tyr Tyr Thr Ser Leu 290 295 300Arg Pro Ile Ser Glu Arg Thr Phe Ala Lys Leu Gln Ser Leu Ala Pro305 310 315 320Arg Leu Leu Pro Leu Arg Gln Pro Ser Pro Ala Ser Pro Gly Pro Ala 325 330 335Ser Phe His His His His Asn His Asn Arg Pro Ser Leu Thr Ser His 340 345 350Pro Ser Gly Tyr Ala Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Ser 355 360 365Asp Pro Arg Pro Asn Ser Val Ala Gly Ser Pro His Leu Ser Ser Val 370 375 380Gly Trp Ala Ser Pro Thr Leu Ser Ser Met Pro Ser Pro Ser Ser Ala385 390 395 400Ser Ala Pro Glu Tyr Pro Tyr Pro Glu Pro Ser Asn His Gln Tyr Pro 405 410 415Gly Ser Ile Thr Pro His Met Phe Phe Pro Arg Arg Pro Gln Ser Ser 420 425 430Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys Leu Glu Leu 435 440 44517230PRTArtificial Sequencesynthesized 17Met Gln Pro Leu Ser Lys Thr Glu Lys Pro Pro Lys Asp Pro Ala Asn1 5 10 15Thr Asn Thr Ala Ser Pro Leu Ala Ala Ala Ser Val Ser Gln Thr Ser 20 25 30Gln Thr Thr Gln Pro Leu Gln Thr Ser Gln Val Ser Ala Pro Ser Gln 35 40 45Ala Pro Gln Thr Ser Gln Ser Thr Ser Pro Asn Ser Ser Thr Thr Gln 50 55 60Ser Ser Pro Gln Ser Thr Ser Gln Thr Ser Ser Ser Phe Ser Arg Glu65 70 75 80Pro Lys Asp Ala Pro Gln Lys Glu Ser Ser Asn Glu Ala Ser Asn Glu 85 90 95Ala Ser Asp Ser Asp Lys Ser Leu Ser Thr Ser Lys Ser Ala Pro Glu 100 105 110Ser Ala Gly Ser Ala Glu Asn Gln Ala Asp His Asp Asp Ala Lys Glu 115 120 125Lys Lys Leu Glu Lys His Phe Phe Cys Arg Ile Cys Lys Gln Gly Phe 130 135 140Thr Arg Lys His Asn Met Val Ser His Glu Leu Ile His Ser Ser Asn145 150 155 160Lys Pro His Val Cys Ser Val Cys Asp Ala Thr Phe Arg Arg Ile His 165 170 175Asp Leu Arg Arg His Glu Lys Leu His Ser Gly Glu Lys Pro Phe His 180 185 190Cys Gln His Cys Asn Arg Gly Phe Ala Arg Thr Asp Ala Leu Thr Arg 195 200 205His Ile Asn Ser Ser Asn Ala Cys Leu Val Lys Gln Arg Gln Thr Arg 210 215 220Lys Arg Thr Asn Leu Ile225 23018259PRTArtificial Sequencesynthesized 18Met Asp Ile Arg Asn Leu Leu Asn Glu Thr Glu Asn Ile Glu Lys Pro1 5 10 15Phe Arg Cys Thr Trp Asn Asp Cys Asp Lys Lys Phe Ser Arg Lys Ser 20 25 30Asp Leu Ser Arg His Ile Arg Ile His Thr Gly Glu Arg Pro Tyr His 35 40 45Cys Gly Trp Pro Ser Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu 50 55 60Thr Val His Tyr Arg Thr His Thr Gly Glu Arg Pro His Val Cys Glu65 70 75 80Tyr Asp Ser Cys Gly Lys Ala Phe Ser Asp Ser Ser Ser Leu Ala Arg 85 90 95His Arg Arg Thr His Thr Gly Lys Arg Pro Tyr Ser Cys Leu His Pro 100 105 110Gly Cys Gly Lys Ser Phe Thr Arg Lys Thr Thr Leu Ser Arg His Gln 115 120 125Arg Cys His Asp Pro Lys Trp Glu Ser Tyr Asn Leu Lys Asn His Lys 130 135 140Ile Thr Phe Asn Lys His Glu Glu Ser Asn Glu Cys Leu Ile Val Asp145 150 155 160Gln Gln Pro Phe His Gln Thr Ser Ala Ala Ser Pro Ile Ser Ser Ser 165 170 175Ser Asp Ser Glu Leu Asp Ser Pro Leu Asn Ser Pro Val Glu Tyr Phe 180 185 190Asn Leu Tyr His Gln Arg Gln Gln Leu Pro Phe Ile Lys His His His 195 200 205Pro Met Val Glu Met Pro Gln Arg Ile Lys His Val His Thr Tyr Arg 210 215 220Ile Leu Asp Tyr Asn Ser Phe Gly Asn Asn Pro Ser Ile Ala Pro Leu225 230 235 240Gln Gln Gln Pro Ser Phe Ile His Gln Lys Thr Arg Met Ser Tyr Tyr 245 250 255Asn Phe Pro19436PRTArtificial Sequencesynthesized 19Met Gln Gln His Ala Ser Leu His Asn Gly Ser Thr Pro Glu Arg Gln1 5 10 15Met His Gln Leu Pro Gln Leu Thr Ala Arg Asn Met Pro Glu Pro Pro 20 25 30Met Asp Arg Ala Gly Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser 35 40 45Arg His Thr Met Glu Gly Val Pro Arg Ser Tyr Pro Ser Pro Ser Ala 50 55 60Met Val Gly Ala Pro Met Gln Met Gln Val Pro Val Ser His Met Gly65 70 75 80Pro Gly Pro Val Ile Leu Pro Gly Ile Pro Gln His Asp Met Ser Gln 85 90 95Gly Met Pro Gln Tyr Lys Val Pro Asp Gln Gln Ala Pro Gln Gln Pro 100 105 110Thr Lys Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg 115 120 125Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His 130 135 140Val Cys Asp Phe Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala145 150 155 160Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His Met Cys 165 170 175Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His 180 185 190Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp 195 200 205Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn 210 215 220His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala225 230 235 240Leu Ala Ala Arg Gly Ala Thr Ala Lys Pro Asn Ala Thr Arg Ser Asp 245 250 255Gly Asp Ala Val Ser Asn Arg Gly Ser Pro Leu Thr Thr Pro Ser Pro 260 265 270Gly Gln Arg Thr Leu Ser Met Ser Pro Ser Ala Asp Gly Met His Arg 275 280 285Thr Asn Ser Glu Phe Gln Tyr Met Gly Asn Ser Ser Leu Pro Val His 290 295 300Leu Gln Arg Asp Met His Val Gly Ser Pro Ala Ser Thr Thr Ser Gly305 310 315 320Gly Tyr Asn Thr Gly Met Arg Pro Thr Ser His Pro Thr Ser Tyr Gly 325 330 335Pro Pro Pro Thr Leu Glu Pro Ser Val Glu Gln His Ser Gly Pro Gly 340 345 350Ser Ala Gly Gly Ser Pro His Met Ser Asn Val Gly Trp Gln Ser Pro 355 360 365Ser His Val Ala Ser Pro Ser His Ser Ser Asn Gly Gly Gly Tyr Thr 370 375 380Tyr Pro Asp Pro Asp Ala Tyr Pro Ala Ala Pro Ser Leu Ser Gly Gln385 390 395 400Met Phe Tyr Gly Asn Pro Gly Gln Val Arg Arg Pro Gln Ser Thr Glu 405 410 415Pro Pro Ala Gly Ala Tyr Asp Ile Lys Gly Arg Gln Ser Glu Leu Trp 420 425 430Ala Gly Ala His 43520470PRTArtificial Sequencesynthesized 20Met Met Glu Ser Pro His Met Ile Pro Phe Asp Ser Arg Ala Thr Thr1 5 10 15Thr Gly Pro Leu Gln Arg Pro Val Met Ala Pro Tyr Ile Val Gln Pro 20 25 30Pro Tyr Ser Ser Gly Pro Val Asn Ser Leu Thr Ala Pro His Tyr Gln 35 40 45Val Pro Asn Pro Tyr Gln Phe Gly Gly Tyr Gln Gly Pro Pro Thr Pro 50 55 60Pro His His Ser Thr Pro Phe Lys Ile Glu Tyr Asn Asp Arg Arg Pro65 70 75 80Met Gly His Asp Asn Asp His Gly Arg Val Pro Ser Tyr Ser Arg Glu 85 90 95Met Lys Cys Thr Tyr Ala Glu Gln Ala Pro Ser Pro Ala Arg Ser Asp 100 105 110Ser Gln Ala Ser Thr Val Arg Ser Ser Gly Thr Asn Pro Ser Met Cys 115 120 125Ser Lys Thr Ile Thr Ser Asn Glu Thr Leu Asn Pro Gly Asp Gln Ile 130 135 140Asn Phe Glu Thr Glu Val Asp Glu Leu Met Lys Ala Ile Gln Arg Lys145 150 155 160Ala Asp Leu Gln Val Asp Thr Val Gln Gln Pro Leu Thr Pro Gly Met 165 170 175Ser Pro Val Ser Glu Ala Ser Phe Glu Ser Gln Gly Thr Pro Gly Pro 180 185 190Met Asp Asn Lys Thr Ala Arg Lys Arg Tyr Arg Cys Asp Gly Pro Asn 195 200 205Cys Gln Lys Ser Phe Thr Gln Lys Thr His Leu Asp Ile His Arg Arg 210 215 220Thr His Thr Gly Ile Lys Pro Tyr Asn Cys Asp Phe Pro Gly Cys Asp225 230 235 240Leu Thr Phe Ser Gln Leu Gly Asn Leu Lys Thr His Arg Arg Arg His

245 250 255Thr Gly Glu Arg Pro Phe Ala Cys Asp Lys Cys Asp Arg His Phe Ala 260 265 270Gln Arg Gly Asn Leu Arg Ala His Leu Gln Thr His Gln Gly Leu Lys 275 280 285Pro Phe Val Cys Ile Leu Asp Asp Cys Asn Lys Thr Phe Ser Gln Leu 290 295 300Gly Asn Met Lys Thr His Gln Asn Asn Phe His Lys Lys Thr Leu Lys305 310 315 320Lys Leu Thr Met Lys Phe Ala Lys Ile Ile Ala Ser Gly Glu Glu Val 325 330 335Thr Glu Ala Asp Arg Glu Leu Phe Glu Tyr Phe Ala Thr His Tyr Lys 340 345 350Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Ala Arg Thr Val Ala 355 360 365Glu Arg Lys Thr Lys Ala Ser Gln Ser Pro Ala Asn Thr Met Thr Ala 370 375 380Val Pro Gln Tyr Pro Leu Pro Gln Ile Ala Ser Thr Pro Val Thr Pro385 390 395 400His Gly Leu Pro Val Ser Gly Ser Leu Ala Ser Tyr Ser Val Thr Arg 405 410 415Gly Gln Pro Ala Pro Ile Asn His Met Ser Arg Gln Thr His Asn Gly 420 425 430Gly Tyr Glu Val Tyr Asp Met His Gly His His His Val Gln Pro Pro 435 440 445Asn Asn Asn Gly Met Leu Tyr Glu Thr Gly Ser Thr Arg Glu Met Gly 450 455 460Tyr His Gly Arg Met Tyr465 47021445PRTArtificial Sequencesynthesized 21Met Glu Thr Ala Glu Pro Val Ser Tyr Glu Phe Thr Gly His Ala Met1 5 10 15Gly Ser Met Ala Pro Arg Arg Leu Leu His Ala Gly Leu Gly Ser Asn 20 25 30Phe Ser Tyr Tyr Asn Asn Pro Ala Thr Ser Phe Pro Leu Pro Tyr His 35 40 45Gln Ser Ser Ser Thr Pro Tyr Gly Phe Ser His Thr Ile Asn Gln His 50 55 60Pro His Gln Leu Pro Gly Tyr Gln His Phe Tyr Leu Thr Gly His Pro65 70 75 80Ser Leu Asn Leu Gln Pro Val Arg Leu Ser Ser Glu Pro Pro Thr Val 85 90 95Gln Gln Ile Pro Asp Ile Arg Pro Ala Lys Asn Ala Ile Ser Arg Ile 100 105 110Val Gly Lys Pro Leu Ala Lys Ser Glu Gln Ser Val Ser Ser Gln Pro 115 120 125Ile Ala Ala Ala Gln Pro Pro Ala Thr Gly Ala Thr Gln Glu Lys Gly 130 135 140Pro Gly Ser Thr Glu Ile Glu Phe Ser Thr Glu Val Asp Ile Leu Met145 150 155 160Lys Ala Ile Gln Ala Lys Ala Val Pro Gln Gln Ser Ala Leu Gln Ser 165 170 175Leu Pro Pro Leu Gln Gln Leu Thr His Ser Gly Glu Asn Gly Phe Ser 180 185 190Gln Thr Ser Tyr Ala Met Ala Ser Ser Thr Pro Arg Cys Asn Met Ala 195 200 205Val Glu Glu Leu Ala Ser Arg Pro Gly Lys Lys Arg Lys Tyr Ile Cys 210 215 220Arg Leu Ser Asn Cys Gly Lys Ser Phe Ala Gln Lys Thr His Leu Asp225 230 235 240Ile His Met Arg Ala His Thr Gly Asp Lys Pro Phe Val Cys Lys Glu 245 250 255Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu Lys Thr His 260 265 270Gln Arg Arg His Thr Gly Glu Lys Pro Phe Ser Cys Asp Ile Cys Gln 275 280 285Lys Arg Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Thr His 290 295 300Gln His Ala Lys Pro Phe Thr Cys Leu Leu Asp Asp Cys Gly Lys Gln305 310 315 320Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala 325 330 335Ala Thr Leu Arg Thr Leu Thr Leu Lys Phe Ser Gln Met Ser Glu Ala 340 345 350Gln Leu Met Asn Pro Gln Asp Arg Gln Leu Trp Glu Tyr Phe Ala Thr 355 360 365Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg 370 375 380Arg Ile Ser Pro Thr Ser Lys Ser Ser Asp Ser Ser Ala Ser Cys Thr385 390 395 400Arg Met Gln Ser Phe Glu Ser Asp Glu Asp Ile Lys Ala Ser Arg Asp 405 410 415Ser Arg Glu Ala Ser Ser Ala Tyr Thr Gly Ser Ser Ser Gly Glu Glu 420 425 430Glu Asp Pro Glu Ile Tyr Tyr Thr Asp Arg Arg Gly His 435 440 44522441PRTArtificial Sequencesynthesized 22Met Asp Ile Thr Thr Ile Leu Asn Lys Asn Arg Ser Ala Val Ala Ala1 5 10 15Ala Ala Glu Ala Gln Leu Gln His Gln Leu Ala Gln Thr Ala Gln Ile 20 25 30Lys Ser Arg Ser Pro Ser Glu Leu Gly Ser Glu His Asp Ala Gln Gln 35 40 45Pro Gly Arg His Ser Glu Pro Tyr His Pro Ala His Gln Pro Ile Gln 50 55 60Leu Pro Thr Ile Ser Gln Tyr His Ser Pro Ile Gln Thr Asn His His65 70 75 80Ala Ser Met Leu Arg Gly Asp Tyr Ala Gln Asn Gly His Glu Asn Met 85 90 95Phe Arg Asn Met Pro Thr Ser Asn Ser Ser Pro Gly Arg Gly Thr Gly 100 105 110Glu Pro Ala Pro Lys Ser Phe His Cys Gln Thr Cys Ser Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 130 135 140Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 180 185 190Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 195 200 205Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 210 215 220His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr225 230 235 240Glu Ala Asn Leu Arg Gln Gly Lys Val Val Arg Pro Asp Gly Val Tyr 245 250 255Ser Glu Thr Ala Ser Pro His Gly Thr Ala Ser Pro Ala Gln Arg Ser 260 265 270Ser Val Ser Pro Arg His Glu Leu Pro Pro Leu His Ser His Arg Gln 275 280 285Met Gly Asp Tyr Phe Met Ala Ser Ser Ser Leu Pro Pro His Leu Arg 290 295 300Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro Ser Thr Pro Ser Pro305 310 315 320Thr Leu Ser Thr Phe Ser Ala Ala His His Pro Arg Pro Ser Leu Thr 325 330 335Ser His Pro Thr Ser Tyr Gly Pro Pro Gln Pro Leu Glu Pro Pro Pro 340 345 350Asn Ser Gly Ser Arg Pro Gly Ser Val Thr Gly Ser Pro His Met Thr 355 360 365Thr Val Gly Trp Ala Ser Pro Ser Leu Asn Ser Val Pro Ser Pro Gly 370 375 380Ser Val Ser Ala Pro Glu Tyr Thr Tyr Pro Glu Pro Ser Gly Pro Pro385 390 395 400Phe Ala Gly Gly Met Pro Ala His Met Tyr Tyr Pro Asn Ser Thr Ile 405 410 415Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys 420 425 430Val Glu Glu Pro Trp Ala Thr His Ala 435 44023395PRTArtificial Sequencesynthesized 23Met Glu Leu Leu Glu Leu Val Glu Tyr Glu Ser Thr Thr Arg Pro Phe1 5 10 15Gln Cys Asp Trp Glu Ser Cys Asn Lys Ser Phe Asn Arg Lys Ser Asp 20 25 30Leu Gln Arg His Tyr Arg Ile His Thr Asn Glu Arg Pro Tyr Thr Cys 35 40 45Thr Thr Pro Gly Cys Gly Lys Ser Phe Ile Gln Arg Ser Ala Leu Thr 50 55 60Val His Ile Arg Thr His Thr Gly Glu Lys Pro His Gln Cys Gln His65 70 75 80Val Gly Cys Gly Lys Arg Phe Ser Asp Ser Ser Ser Leu Ala Arg His 85 90 95Arg Arg Ile His Thr Gly Lys Arg Pro Tyr Lys Cys Ala His Asp Gly 100 105 110Cys Leu Lys Ser Phe Cys Arg Lys Thr Thr Met Val Lys His Gln Arg 115 120 125Arg Ser His Gln Arg Gly Met Asn Pro Asn Asp Ile Leu Asp Asp Cys 130 135 140Thr Ser Glu Ser Asp Met Gly Glu Ser Pro Ser Thr Pro Gly Gln Thr145 150 155 160Ala Met Ser Trp Ser Met Pro Gly Thr Ile Ile His Pro Ala Met Ala 165 170 175His Ser His Pro Met His Arg Ser Ala Thr Phe Gly Asp Phe Gly Gln 180 185 190Gln Met Thr Pro Tyr Gly Met Asp His Gln Ile Ala Gln Arg Gln Ser 195 200 205Val Pro Ala Glu Val His Glu Phe His Gly Gln Asp Pro Asn Met His 210 215 220Met Ile Gln Arg Thr Ala Asn Ile Pro His Gln Pro Tyr Tyr Val Ile225 230 235 240Asp Gln Asn Asn Pro Gly Ile Ala Thr Met Asn Thr Asn Val Pro Ala 245 250 255Ala Tyr His Ile Pro Arg Gln His Val Glu Arg Ser Leu Glu Met Ala 260 265 270Tyr Asn Ser Gly Ser Met Pro Ser Leu Ser Ser Ser Pro Ala Ser Phe 275 280 285Ser Pro Ala Ser Gly His Ser Ser Ser Met His Asp Gly Leu Tyr Thr 290 295 300His Gln Pro Pro Ala Ser Ala Thr Tyr Gly Leu Gln Glu Ala His Ala305 310 315 320Val Glu Pro Ser Asn Asn Met Val Ser Tyr Thr Gln Gln Met His Gln 325 330 335Thr Arg Ser Ser Gln Pro Glu Ala Glu Trp Val Tyr Gln Tyr Gln Ser 340 345 350Pro Val Glu Val Ala Thr Ile Gly Gln Ile Pro Ala Phe Gly Thr Gly 355 360 365Val Tyr Asp Met Tyr Ser Gly Pro Lys Ile Asp Phe Asp Asp Pro Thr 370 375 380Met Gln Leu Pro Ser Ser Arg Val Glu Thr Leu385 390 39524447PRTArtificial Sequencesynthesized 24Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Gly Thr Ala Ala Val Ala1 5 10 15Ala Ala Glu Ala His Leu Gln Gln His Leu Val His Ala Thr His Met 20 25 30Lys Ser Lys Thr Pro Ser Glu Ile Ser Ser Glu His Gly Thr Pro Gln 35 40 45Asn Gly Asp Gln Ser Asn Ile Tyr His Pro Thr Ser Gln Pro Asn Pro 50 55 60Gln Leu Val Gly Ser Ser Lys Tyr His His Ser Gln Ser Gln Gly His65 70 75 80Ala Gly Ile Pro Pro Val Arg Ser Asn Tyr Val Gln Asp Gly Gln Gly 85 90 95Ile Val Lys Tyr Leu Gln Asn Gly Asn Gly Gly Asn Gly Arg Ser Ser 100 105 110Gly Glu Pro Val Pro Lys Thr Phe His Cys Ser Thr Cys Ser Lys Gly 115 120 125Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly 130 135 140Ile Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile145 150 155 160Gln Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys 165 170 175Pro His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 180 185 190Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 195 200 205Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr 210 215 220Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu225 230 235 240Thr Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Val Arg Pro Pro 245 250 255Asp Gly Met Tyr Ser Glu Ala Gly Ser Thr Gln Ser Thr Pro Ser Pro 260 265 270Gly Gln Arg His Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Met Tyr 275 280 285Leu Pro Arg Gln Met Ser Asp Tyr Tyr Met Gly Asn Thr Pro Ile Pro 290 295 300Ala His Leu Arg Gly Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro305 310 315 320Ser Thr Ser Ser Pro Pro Leu Ser Thr Tyr Ser Ser Val Pro His Ala 325 330 335Arg Pro Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro 340 345 350Val Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Val Ala Gly 355 360 365Ser Pro His Ile Thr Ser Met Gly Trp Ala Ser Pro Thr Leu His Ser 370 375 380Ile Gly Ser Pro Asp Ser Ala Ser Ala Thr Glu Tyr Ser Tyr Pro Glu385 390 395 400Pro Ser Ala Pro Ser Tyr Pro Ser Gln Ile Pro Pro His Met Tyr Phe 405 410 415Pro Asn Ser Thr Ile Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr 420 425 430Glu Pro Lys Pro Lys Leu Asn Gly Asp Ser Trp Thr Thr Pro Val 435 440 44525368PRTArtificial Sequencesynthesized 25Met Gln Gln Thr Ser Tyr Tyr Ser Pro Asn Met Pro His Pro Val Ser1 5 10 15Tyr Ala Gln Ser His Asp Ile Gln Gln Leu Pro Thr Leu Pro Asp Val 20 25 30Arg His Val Phe Asn Pro Asn Val Lys Ser Glu Gly Thr Ser Pro Ala 35 40 45Gln Ser Asn Gln Met Tyr Ala Asn Gln Ser Tyr Gly Thr Glu Leu Lys 50 55 60Arg Ser Thr Ser Glu Pro Thr Glu Gly Ser Ser Thr Asn Phe Ala Thr65 70 75 80Asp Val Asp Thr Leu Met Arg Ala Ile Gln Ala Lys Gln Thr Asn Leu 85 90 95Pro Gln Glu Asn Asp Gln Lys Asp Asp Ala Ala Lys Thr Ala Gln Lys 100 105 110Pro Arg Lys Arg Tyr Gln Cys Thr Val Pro Asn Cys Asn Lys Ser Phe 115 120 125Tyr Gln Lys Thr His Leu Glu Ile His Ile Arg Ala His Thr Gly Asp 130 135 140Lys Pro Phe Pro Cys Lys Ala Pro Gly Cys Gly Gln Ser Phe Ser Gln145 150 155 160Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly Glu Arg Pro 165 170 175Tyr Ser Cys Asp Ile Cys Gly Lys Thr Phe Ala Gln Arg Gly Asn Val 180 185 190Arg Ala His Lys Ile Val His Gln Gln Ile Lys Pro Phe Ser Cys Lys 195 200 205Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser 210 215 220His Gln Asn Lys Phe His Ala Ala Thr Leu Arg Tyr Leu Thr Thr Lys225 230 235 240Phe Ala Thr Ile Asn Gln Gly Asp Tyr Val Ser Gln Glu Asp Lys Glu 245 250 255Leu Trp Glu Tyr Phe Ala Ser Leu Tyr Lys Asn Ser Asn Lys Gly Ile 260 265 270Lys Gly Arg Gly Lys Asp Arg Arg Ile Ser Ala Met Ser Ser Ser Ala 275 280 285Ser Ser Tyr Pro Ser Ser Tyr Ala Ala Met Pro Met Ala Ser Met Ser 290 295 300Arg Gly Tyr Ala Ser Ser Phe His Gln His Ser Ser Asp Arg Ser Ser305 310 315 320Arg Cys Ser Ser Met Ser Ser Asp Thr Ile Pro Ile Gln Arg Ala Asp 325 330 335Ser Ala Tyr Asp Phe Ser Ala Pro Met His Asn Gly Tyr His Gln Pro 340 345 350Gln Gly Asn Gly Tyr Asp Asp Met Val Phe Pro Glu Arg Lys Met Tyr 355 360 36526467PRTArtificial Sequencesynthesized 26Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Ile Val1 5 10 15Ala Ala Asp Val His Gln Leu Gln Gln His Leu Ala Gln Ala Gln Ser 20 25 30Gln Ser Gln Thr Asp Asp Ala Val Lys Ser Arg Ser Pro Ser Glu Leu 35 40 45Gly Ala Ser Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His 50 55 60His His His His His His His His Gln Pro Thr Ser Ser Phe Pro Ser65 70 75 80Ser Thr Gln Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val 85 90 95Gln Ala Gln Ala Asn His Ala Gly Thr Ser Pro Gly Tyr Ala His Ser 100 105 110Ala His Gly Ser Asp Tyr Gly Arg Ser Ser Thr Ser Met Arg Pro Thr 115 120

125Gly Leu Pro Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly 130 135 140Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly145 150 155 160Ile Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile 165 170 175Gln Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys 180 185 190Pro His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 195 200 205Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 210 215 220Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr225 230 235 240Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu 245 250 255Thr Glu Ala Asn Leu Arg His Ser Lys Asp Arg Ser Thr Ala Ser Arg 260 265 270Pro Ser Glu Tyr Ser Glu Pro Gly Ser Ala His Ser Thr Pro Ser Pro 275 280 285Ala Gln Arg Pro Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn 290 295 300Leu Ser Ser Arg Pro Ser Ala Ala Gly Gly Pro Thr Ser Ala Gly Gly305 310 315 320Ser Ala Asp Tyr Tyr Thr Ser Leu Pro Pro His Leu Arg Thr Asp Phe 325 330 335Ala Asn Ser Ser Pro Arg Ala Ser Pro Thr Ser Pro Ser Pro Thr Leu 340 345 350Thr Ser Leu Ser Gly Pro Ala Ser Phe His His His Asn His Asn Arg 355 360 365Pro Ser Leu Thr Ser His Pro Ser Gly Tyr Ala Pro Pro Gln Pro Leu 370 375 380Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Val Ala Gly Ser385 390 395 400Pro His Leu Ser Ser Val Gly Trp Ala Ser Pro Thr Leu Ser Ser Met 405 410 415Pro Ser Pro Ser Ser Ala Ser Ala Pro Glu Tyr Pro Tyr Pro Glu Pro 420 425 430Ser Ser His Gln Tyr Pro Gly Ser Ile Thr Pro His Met Phe Phe Pro 435 440 445Arg Arg Pro Gln Ser Ser Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys 450 455 460Leu Glu Leu46527475PRTArtificial Sequencesynthesized 27Met Gln Tyr Glu Val Pro Met Pro Leu Ser Met Asn His Asp Met His1 5 10 15Thr Pro Asn Gly Asn Tyr Leu Gly Gln Asn Leu Tyr Val Pro Thr Ala 20 25 30Asn Arg Ile Lys Ser Glu Asn Gly Ser Asp Arg Gly Val Ser Pro His 35 40 45Ser Ser Glu His Ser Ser Arg Tyr Ser Ser Thr Ala Pro Gln Asn Ser 50 55 60Val Ala Tyr Gln Gln Ile Ala Ala Gln Leu Thr Asn Gly Met Arg Tyr65 70 75 80Pro Ser Pro Ser Met Pro Gln Ser Asn Ser Met Pro Met Leu Gln Gln 85 90 95His Tyr Gln Pro Thr Gly Thr Pro Asp Ser Asn Tyr Pro Gln His Thr 100 105 110Pro Thr Leu Gly Ala Thr Gln Gln Ser Thr Pro Gln Glu Pro Ser Pro 115 120 125Met Glu Gly Ala Arg Thr Ser Thr Gly Ser Ser Gly Leu Pro Lys Ala 130 135 140Phe Ala Cys Ser Thr Cys Asn Lys Gly Phe Ala Arg Arg Ser Asp Leu145 150 155 160Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro His Val Cys Asp 165 170 175Tyr Ala Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val 180 185 190His Ser Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys 195 200 205Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile 210 215 220His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys225 230 235 240Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr 245 250 255Gly Thr Ile Glu Glu Ser Glu Ala Ala Thr Ala Ala Ala Leu Ala Ser 260 265 270Arg Val Ser Met Gln Gly Gln Arg Ser Arg Gly Ser Asp Asp Glu Asn 275 280 285Asp Phe Ser Asp Asn Gly Lys Ser Pro Leu Pro Gln Pro Asp Arg Gln 290 295 300Ser Thr Asn Ser Pro Ala Ala Gly Met Asn Asn Met Pro Thr Leu Gln305 310 315 320Arg Gln Thr Ser Glu Phe Tyr Met Asn Ala Ile Ser Gly Gly Met Ala 325 330 335Ala Val Pro Pro His Met Arg Ser Gln Val Gln Ala Ser Pro Arg Ala 340 345 350Gln Ser Pro Gln Gln Tyr Ser Met Pro Gly Asn Asn Gly Thr Pro Gln 355 360 365Pro Arg Ile Thr Ser Ile Ser Ala Ala Gly Tyr Asn Gly Pro Pro Gln 370 375 380Ile Met Glu Pro Pro Thr Thr Asn Gly His Gln Gln Thr Gly Ser Gly385 390 395 400His Asn Ser Pro His Leu Asn Gly Trp Gln Ser Pro His Asn Gly Met 405 410 415Gly Pro Gly Gln His Gln Thr Thr Asp Tyr Ser Tyr Gln Asp Ala Ser 420 425 430Gly Tyr Pro Ser His Ser Val Asn Ala Met His Ala Tyr Tyr Gln Ala 435 440 445Pro Asn Val Ser Arg Pro His Ser Thr Gly Pro Val Asp Tyr Ser Ser 450 455 460Gly Leu Arg Gln Asp Val Trp Thr Gln Gln Pro465 470 47528482PRTArtificial Sequencesynthesized 28Met Ser Gln Ser Pro Ser Ser Gly Gly Ala Met Gly Ile Gly Ser Val1 5 10 15Leu Asn Ile Lys Ala Glu Ser Gly Met Leu Gln Pro Gln Gln Gly Leu 20 25 30Ala Pro Glu Gln Gln Gln Gln Gln Gln Gln Gln Glu Gln Gln Gln Gln 35 40 45Gln Gln Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Gln Gln Gln Gln 50 55 60Gln Gln Gln Pro Ser Arg Pro Ala Gln Thr His Gln Ile Gln Gly Asp65 70 75 80Gln Pro Asp Ala Ser His Gly Ser Glu Gln Ser Arg Tyr Ser Gly Pro 85 90 95Met Asn Ala Ser Tyr Pro Ser Pro Thr Ala Met Ala Ala Ala Pro Leu 100 105 110Pro Pro Val Pro Ser Ala Asn Met Ala Pro Ala Pro Met Asn Ser Ala 115 120 125Met Leu His Pro Asp Leu Pro Pro Glu Leu Val Ala Gly Ile Pro Pro 130 135 140Gly Gly Tyr Ala Pro Ala Glu Ala Arg Ala Gln Pro Ala Lys Ser Phe145 150 155 160Pro Cys Gly Thr Cys Gly Lys Pro Phe Thr Arg Arg Ser Asp Leu Ala 165 170 175Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Ala Cys Asp Tyr 180 185 190Pro Gly Cys Asp Lys Arg Phe Ile Gln Arg Ser Ala Leu Thr Val His 195 200 205Ser Arg Val His Thr Gly Glu Lys Pro His Gln Cys Glu Arg Cys Gly 210 215 220Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His225 230 235 240Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Glu Asp Cys Gln Lys Thr 245 250 255Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Val Gly 260 265 270Thr Val Glu Asp Ser Ala Arg Ala Arg Ala Glu Ala Leu Ala Gln Gly 275 280 285Ala Ser Ala Ala Ala Ala Ala Ala Ala Arg Asn Lys Ser Arg Ser Ser 290 295 300Ser Glu Gln Ala Ser Asn His Glu Ser Pro Leu Thr Thr Pro Ser Pro305 310 315 320Ala Gln Gly Ala Met Ser Met Ser Pro Ser Ala Asp Leu Ala Asn Met 325 330 335Asn Ser Met Gln Tyr Leu Ala Asn Asn Ser Leu Pro Pro His Leu Arg 340 345 350Gly Asp Val His Val Gly Ser Pro Ser Pro Thr Ala Ser Thr Gly Tyr 355 360 365Asn Asn Gly Met Arg Pro Thr Ser His Pro Thr Gly Tyr Ala Pro Pro 370 375 380Gln Thr Met Glu Pro Ser Ile Glu His Gln Gln Gly Pro Gly Ser Val385 390 395 400Ala Gly Ser Pro His Val Ala Ser Val Gly Trp Pro Ser Pro Gly Pro 405 410 415Val Gly Ser Pro Thr Gln Ser Pro Asn Gly Asn Gly Tyr Thr Tyr Pro 420 425 430Asp Pro Ser Asp Val Tyr Gln Ser Gly Thr Pro Ile Ala Gln Met Phe 435 440 445Tyr Asn Ser Ala Pro Ala Thr Arg Arg Pro Gly Ser Ala Glu Pro Gly 450 455 460Asn Pro Ala Tyr Asp Ala Lys Gly Arg Gln Ala Glu Leu Trp Thr Asn465 470 475 480Ala Gln29388PRTArtificial Sequencesynthesized 29Met Ser Pro Ser Pro Thr Pro Gln Pro Trp Asp Gln Trp Ser Gln Gln1 5 10 15Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln His His Ser Gly 20 25 30Tyr Pro Leu Met Asp Gln Ser Val Phe Pro Gln Tyr Ala Ser Gln Pro 35 40 45Thr Gln Tyr Asp Pro Arg Thr Ser Gln Tyr Asp Pro Arg Thr Val Val 50 55 60Thr Ser Gly Pro Leu Val Ala Pro His Met Ala Thr His Tyr Val Thr65 70 75 80Ala Pro Ala Tyr Gly Ala Ser Pro Ile Ser Asn Met Lys Pro His Phe 85 90 95Pro Ala Gln Thr His Tyr Ser Tyr Gly Gln Tyr Asp Gln Pro Ala Gly 100 105 110His Leu Ala Met Ala Tyr Ser Ser His Pro Ala Ser Pro Met Thr Pro 115 120 125Gly Pro Met Asn Thr Lys Asp Ile Thr Tyr Asn Lys Pro Ala Leu Gln 130 135 140Lys Arg Lys Asp Lys Glu Glu Leu Ala Ser Ser Asn Ser Ser Glu Ala145 150 155 160Gly Ala Gly Ser Val Lys Ser Glu Pro Ser Ser Pro His Pro Ser Ser 165 170 175Thr Asp Gly Ser Gln Glu Thr Thr Asp Lys Val Lys Lys Tyr Arg Cys 180 185 190Pro Tyr Asp Gly Cys Pro Lys Ser Phe Gln Gln Ser Thr His Leu Glu 195 200 205Thr His Lys Arg Ala His Thr Gly Asp Lys Pro Tyr Lys Cys Glu Trp 210 215 220His Gly Cys Gly Arg Arg Phe Ser Gln Pro Gly Asn Leu Lys Thr His225 230 235 240Thr Arg Leu His Thr Gly Glu Arg Pro Phe Glu Cys Glu Met Cys Gly 245 250 255Thr Cys Phe Ala Gln Arg Gly Asn Leu Thr Ala His Lys Ala Thr His 260 265 270Ser Lys Thr Lys Pro Phe Val Cys Lys Leu Asp Thr Cys Asn Lys Cys 275 280 285Phe Thr Thr Arg Gly Asn Leu Lys Asn His Gln Asn Lys Tyr His Lys 290 295 300Glu Thr Ile Ala Gln Leu Val Asp Trp Ile Ile Ser Leu Thr Asp Val305 310 315 320Asp Ala Leu Ser Pro Lys Asp Arg Asp Leu Leu Trp Tyr Phe Ser Asn 325 330 335Ile Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Arg Asp Arg 340 345 350Arg Val Ser Glu Val Arg Met Gly Lys Thr Lys Leu Asn Ser Pro Gly 355 360 365Met Gly Leu Pro Arg Ser Lys Met Leu Asp Ser Ser Phe Ser Arg Leu 370 375 380Gly Leu Gly Phe38530335PRTArtificial Sequencesynthesized 30Met Arg Pro Ser Lys Leu Lys Arg Pro Ile Leu Leu Lys Cys Ala Phe1 5 10 15Cys Ile Leu Glu Asn Pro Cys Glu Pro Val Lys Thr Trp Gly Arg Arg 20 25 30Gly Asp Leu Asn Arg His Met Arg Lys His Gly Asp Val Lys Pro Tyr 35 40 45Tyr Cys Thr Arg Cys Val Lys Gly Phe Val Gln Lys Ser Ala Met Glu 50 55 60Thr His Met Asn Thr His Thr Gly Ala Lys Pro His Ala Cys Pro Val65 70 75 80Ser Gly Cys Gly Lys Lys Phe Gly Asp Pro Ser Ser Arg Thr Arg His 85 90 95Lys Asn Glu Ala His Ser Ser Ile Ala Ala Phe Arg Cys Pro Glu Val 100 105 110Gly Cys Pro Thr Arg Ile Lys Arg Lys Gly Thr Phe Ile Lys His Leu 115 120 125Thr Val His His Asn Trp Leu Thr Arg Pro Thr Glu Gln Gln Leu Met 130 135 140Asp Met Ile Val Tyr His Ala Lys Gly Glu Ser Ala Lys Gln Glu Ser145 150 155 160Glu Gly Ala Lys Gln Glu Gly Gln Gly Ala Lys Gln Glu Val Gln Ser 165 170 175Ala Lys Gln Glu Ser Gln Val Val Lys Gln Glu Thr Gln Val Val Lys 180 185 190Gln Glu Thr Gln Val Val Lys Gln Glu Ser Pro Ser Ala Lys Gln Glu 195 200 205Ser Val Glu Pro Ser Val Leu Asp Ala Leu Val Ser Arg Ser Ser Pro 210 215 220Ser Pro Thr Thr Arg Arg Leu Ser Ser Ser Leu Leu Pro Leu Asn Ala225 230 235 240Pro Tyr Ser Phe Asp Lys Tyr Thr Lys Leu Tyr Pro Glu Pro Pro Ser 245 250 255Tyr Asp Ser Tyr His Thr Gly Thr Thr Val Tyr Ser Gln Pro Val Asp 260 265 270Pro Trp Gln Glu Leu Ser Ser Tyr Ala Asp Gly Leu Leu Leu Ser Ser 275 280 285Thr Ser Ser Ser Ser Leu Pro Val Ser Thr Ser Met Ile Ser Trp Asp 290 295 300Ser Asp Pro Asp Met Met Val Tyr Pro Thr Tyr Arg Ser Gly Tyr Thr305 310 315 320Ser His Pro Pro Leu Ser Tyr Asp Trp Ser Leu Gly Leu Leu Gly 325 330 33531456PRTArtificial Sequencesynthesized 31Met Glu Thr Ala Glu Pro Val Ser Tyr Glu Phe Pro Gly His Thr Ile1 5 10 15Gly Ala Val Ala Pro Arg Arg Met Met Thr Ser Asn Leu Gly His Asn 20 25 30Phe Pro Phe Tyr Ala Thr Pro Ala Ala Ser Phe Pro Leu Pro Phe His 35 40 45Gln Ser Ser Ser Thr Ala Tyr Gly Phe Gly His Ala Leu Asn His His 50 55 60His His Asn His His Gln Pro Ser Tyr Pro Gln Phe Phe Val Ala Ser65 70 75 80His Glu Ser Ile Asn Ser Gln Pro Met Arg Leu Ser Ser Glu Pro Pro 85 90 95Pro Val Gln Ser Ile Pro Asp Ile Arg Pro Ala Lys Asn Ala Val Asn 100 105 110Arg Val Ser Arg Asp Pro Leu Val Lys Asn Asp Pro Ser Ser Asn Thr 115 120 125Gln Gln Thr Pro Met Ala Arg Ser Ser Thr His Gly Ala Ala Ala Gln 130 135 140Ser Lys Ser Pro Ser Val Ser Glu Ile Glu Phe Thr Thr Glu Val Asp145 150 155 160Ile Leu Met Lys Ala Ile Gln Ser Arg Asn Ser Val Gln Pro Pro Asn 165 170 175Thr Gln Ser Leu Pro Pro Leu Gln Gln Leu Thr His Arg Gly Cys His 180 185 190Gly Tyr Pro Gln Thr Phe Ser Leu His Pro Ser Gly Asn Thr Arg Cys 195 200 205Asn Met Met Ala Glu Glu Val Gln Ser Arg Ser Gly Lys Lys Arg Lys 210 215 220Tyr Val Cys Thr Leu Pro His Cys Gly Lys Ser Phe Ala Gln Lys Thr225 230 235 240His Leu Asp Ile His Thr Arg Ala His Thr Gly Asp Lys Pro Phe Ile 245 250 255Cys Lys Glu Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu 260 265 270Lys Arg Glu Lys Thr Asp Ser Asn Pro Gly Ala His Lys Gln Thr His 275 280 285Gln Arg Arg His Thr Gly Glu Lys Pro Phe Ser Cys Asp Ile Cys Gln 290 295 300Lys Arg Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Thr His305 310 315 320Gln His Ala Lys Pro Phe Thr Cys Leu Leu Asp Asp Cys Gly Lys Gln 325 330 335Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala 340 345 350Thr Thr Leu Arg Asp Leu Thr Leu Lys Phe Ser Gln Val Thr Ile Gly 355 360 365Asp Pro Met Ser Pro Gln Asp Arg Lys Leu Trp Glu Tyr Phe Ala Thr 370 375 380Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg385 390 395 400Arg Ile Ser Pro Thr Ser Arg Ser Gly Pro Gly Lys Arg His Gln Thr 405 410 415Leu Gly Asn Asn Asp Asp Lys Leu Gln Arg Pro Ile Tyr Glu Glu Ser 420 425 430Ser Val Tyr Thr Gly Gly Ser Ser Ser Asp

Glu Glu Asp Ala Glu Ala 435 440 445Tyr Tyr Ile Asp Arg Gln Asn His 450 45532457PRTArtificial Sequencesynthesized 32Met Asp Ile Lys Glu Ile Val Asn Ser Lys Gly Ala Lys Gly Ala Ala1 5 10 15Ala Ala Ala Ala Ala Ser Ala Ser Gly Gln Ala Gln Ala Gln Ala Gln 20 25 30Asp Leu His Leu Leu Gln Thr Ile Ser Gln Ala Asn Gly Met Arg Met 35 40 45Ser Asp Thr Gly Ser Glu Arg Gly Thr Ser Pro His Gly Ser Glu His 50 55 60Ser Gln Tyr Ser Thr Pro Arg Met Gly Met Asn Val Met Asn Gly Ala65 70 75 80Pro Asn Gly Met Arg Tyr Pro Ser Pro Pro Gly Met Gln Asn Ala Met 85 90 95Pro Met Met Gln Gln Pro Tyr Arg Pro Asp Ile Pro Phe Asp Asn Ser 100 105 110Met Met Pro Thr Gln Gln Gln Asp Asn Thr Arg Gln Arg Gln Pro Gly 115 120 125Asp Val Thr Val Thr Lys Ala Phe Pro Cys Ser Thr Cys Gly Lys Gly 130 135 140Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly145 150 155 160Val Arg Pro His Val Cys Asp Tyr Pro Gly Cys Gly Lys Gln Phe Ile 165 170 175Gln Arg Ser Ala Leu Thr Val His Leu Arg Val His Thr Gly Glu Lys 180 185 190Pro His Thr Cys Glu Arg Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser 195 200 205Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 210 215 220Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr225 230 235 240Arg His Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala 245 250 255Thr Ala Ala Ala Leu Ala Thr Arg Pro Gly Asn Asn Arg Pro Ser Arg 260 265 270Gln Arg Ser Asp Gly Glu Ser Tyr Ser Asn Asn Gly Ser Pro Met Ser 275 280 285Thr Pro Ser Pro Gly Arg His Leu Ser Ala Ser Pro Ser Ser Asp Met 290 295 300Ala Pro Met Asn Ser Met Gln Arg His Pro Gly Asp Tyr Gly Tyr Met305 310 315 320Asn Asn Ser Ser Leu Pro Gly His Leu Arg Gly Asp Tyr Gly Val Pro 325 330 335Ser Gln Pro Pro Pro Val Ser Thr Ala Phe Ala Asn Gly Met Gln Gln 340 345 350Gln Arg Pro Thr Ser His Pro Thr Gly Tyr Gly Pro Pro Asn Ile Leu 355 360 365Glu Pro Pro Ala Asn Met Glu Gln Arg Gln Pro Gly Ser Ala Asn Gly 370 375 380Ser Pro His Met Thr Asn Met Gly Trp Gln Ser Pro Ser His Met Gly385 390 395 400Ser Pro Ser His Asn Asn Asn Tyr Val Tyr Pro Asp Pro Asp Pro Tyr 405 410 415Gly Ser Gly Ala Ala Ile Gly Gln Met Tyr Tyr Pro Asn Ser Asn Met 420 425 430Arg Arg Pro Gln Ser Thr Glu Pro Glu Gln Tyr Asp Met Lys Pro Arg 435 440 445Met Gly Asp Leu Trp Ala Thr Ala Gln 450 45533472PRTArtificial Sequencesynthesized 33Met Lys Arg Lys Gln Asp Asp Glu Arg Leu Asp Gly His Asp Gly Pro1 5 10 15Asp His Ala Gln Val Gln Ser Lys Lys Arg Ala Thr Asp Trp Val Gln 20 25 30Gln Gln Gln Glu Glu Glu Leu Ser Gln Val Glu Gln Leu Glu Ala Pro 35 40 45Ala Leu Pro Ser Gln Ser Arg Ser Pro Pro Ala Gly Ala Glu Ala Ala 50 55 60Ala Ser Asp Gly Asn Gly Asn Asp Ser Leu Glu Leu Asp Pro Asp Ser65 70 75 80Ala Ser Val Ala Ser Val Ala Asn Thr Ser Leu Thr His Ala Asp Pro 85 90 95Thr Thr Thr Val Ala Ala Thr Ser Ile Asn Thr Thr Thr Thr Arg Ala 100 105 110Ser Arg Arg Phe Pro Ser Asp Leu Lys Thr Ile Arg Cys Thr Phe Ala 115 120 125Gly Cys Thr Lys Thr Phe Asn Arg Pro Ala Arg Leu Ala Ala His Leu 130 135 140Arg Ser His Thr Asn Asp Arg Pro Phe Lys Cys Pro Tyr Asp Asp Cys145 150 155 160Asp Lys Asp Tyr Leu Glu Glu Lys His Leu Ser Gln His Ile Lys Gly 165 170 175Ser His Thr Asn Asp Arg Lys Tyr Thr Cys Pro Glu Pro Gly Cys Gly 180 185 190Lys Ser Phe Val Thr Asn Thr Arg Leu Arg Arg His Ala Leu Val His 195 200 205Glu Gly Ala Asp Arg Tyr Arg Cys Arg Gly Tyr Gly Asp Cys Val Gln 210 215 220Ser Phe Arg Lys His Gln Thr Leu Gln Arg His Ile Arg Thr Val His225 230 235 240Leu Gly Lys Ser Ala Tyr Pro Cys Gly Asn Asp Gly Cys Asp Ala Gly 245 250 255Phe Asp Thr Ala Ser Ala Leu Arg Arg His Val Glu Arg Glu His Gly 260 265 270Asp Leu Lys Phe Trp Cys Asp Glu Cys Asn Ala Glu Gly Glu Gly Asp 275 280 285Asp Ser Gly Gly Arg Arg Val Gly Phe Thr Thr Met Leu Leu Leu Gln 290 295 300Ala His Met Lys Lys Glu His Asn Asn Cys Ala Phe Cys Gly Val Arg305 310 315 320Cys Gly Thr Gln Ser Asn Met Met Arg His Val Glu Leu Tyr His Ser 325 330 335Ala Lys Thr Val Glu Asp Arg Lys Thr Ile Ala Cys Thr Trp Glu Gly 340 345 350Cys Asp Lys Lys Phe Thr Arg Val Ser Asn Leu Asn Thr His Ile Lys 355 360 365Ser Ala His Glu Gly His Arg Phe Val Cys Gly Gln Thr Asp Thr Tyr 370 375 380Asp Ala Lys Val Ser Glu Ile Ala Asp Trp Asn Phe Ala Glu Glu Gly385 390 395 400Cys Gly Gln Gly Phe Thr Thr Arg Val Lys Leu Glu Glu His Val Leu 405 410 415His Val His Leu Gly Lys Lys Arg Pro Pro Lys Leu Tyr Pro Val Pro 420 425 430Ser Met Val Ala Gln Ala Gln Gln Ala Gln Gln Ala Leu Leu Asp Thr 435 440 445Arg Asp Leu Ala Cys Pro Ala Arg Gly Thr Gly Ser Tyr Gly Thr Ile 450 455 460Ser Glu Cys Cys Gln Leu Glu Arg465 47034441PRTArtificial Sequencesynthesized 34Met Asp Ile Thr Thr Ile Leu Asn Arg Lys Gly Ser Ala Ala Met Val1 5 10 15Ala Ala Asp Gly Gln Phe Asp His Gln His Leu Val Pro Asn His Ser 20 25 30Ile Asp His Thr Ser Ser Pro Lys Met Lys Ser Glu Pro Gly Val Ser 35 40 45Asp Ala Gly Asp Gln Ala Val Leu Ala Tyr Pro Pro His Gly Pro Leu 50 55 60Gly Gln Val Pro Thr Met Pro His Asp Met Arg Tyr Ala Pro Gln Ala65 70 75 80His Pro Ala Pro Gly Leu Pro Leu Leu Gln Asn Pro Phe Val Ser Gly 85 90 95Gly Tyr Ala Gly Ser Ala Gln Ile Pro Asn Ala Gly Ala Pro Gln Gly 100 105 110Arg Pro Asp Pro Pro Pro Lys Thr Phe His Cys Gly Thr Cys Gly Lys 115 120 125Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser 130 135 140Gly Val Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe145 150 155 160Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu 165 170 175Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser 180 185 190Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys 195 200 205Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu 210 215 220Thr Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala225 230 235 240Glu Thr Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Arg Leu Pro 245 250 255Gly Asp Met Phe Ser Glu His Gly Ser Val His Ser Thr Pro Ser Pro 260 265 270Ala His His Pro Ile Ser Pro Val Gly Asp Leu Pro Pro Leu Asn Met 275 280 285Pro Arg Ser Asp Tyr Tyr Met Pro Asn Gly Ser Ile Pro Ala His Val 290 295 300Arg Gly Gly Phe Thr Gln Ala Ser Pro Arg Ala Ser Pro Thr Ala Thr305 310 315 320Ser Pro Ser Leu Ser Ser Tyr Gly Ser Ala Pro His Pro Arg Pro Ser 325 330 335Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu Glu Pro 340 345 350Pro Ala Asn Asn Asp His Arg Pro Asn Ser Val Ser Gly Ser Pro His 355 360 365Met Thr Ser Leu Gly Trp Ala Ser Pro Ser His Gly Ser Ile Pro Ser 370 375 380Pro Gly Ser Ala Thr Asp Phe Tyr Pro Glu Thr Ser Gly Pro Ala Tyr385 390 395 400Pro Thr Ser Met Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile Arg 405 410 415Arg Pro Thr Ser Thr Glu Pro Asp Ser Tyr Glu Leu Lys Pro Lys Met 420 425 430Gly Glu Ser Ala Trp Ser Thr Pro Val 435 44035406PRTArtificial Sequencesynthesized 35Met Ala Tyr Leu Ala Asn Gln Leu Asn Gly Gly Val Pro Arg Tyr Pro1 5 10 15Ser Pro Ser Met Gln Gln Gln Gly Ala Met Pro Leu Ile Gln His Thr 20 25 30Tyr His Pro Asn Ala Gly Ser Asp Gln Ser Tyr Gln Pro Gln Ala Ser 35 40 45Met Gly Pro Val Gln Gly Ala Leu Pro Pro Asp Pro Thr Gln Ser Asp 50 55 60Gly Thr Gly Arg Pro Asn Gly Ser Gly Leu Pro Lys Ala Phe Ala Cys65 70 75 80Ser Ser Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His 85 90 95Glu Arg Ile His Ser Gly Val Arg Pro His Ala Cys Asp Tyr Pro Gly 100 105 110Cys Asn Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg 115 120 125Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro 130 135 140Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly145 150 155 160Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr 165 170 175Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile 180 185 190Glu Glu Ser Glu Ala Ala Thr Ala Ala Ala Leu Ala Ser Arg Val Asn 195 200 205Met Gln Ser Arg Ser Arg Gly Ser Asp Glu Glu Gly Asp Tyr Ser Asp 210 215 220Gly Lys Ser Pro Met Pro Gln Gln Pro Asp Arg Val Asn Ser Pro Ala225 230 235 240Ile Asn Val Asn Gly Val Pro Gln Met Gln Arg Gln Gly Ser Asp Leu 245 250 255Tyr Met Gln Val Met Gly Asn Gly Met Ala Ala Ala Ala Ala Phe Pro 260 265 270Gln His Leu Arg Ser Glu Met Gln Gly Ser Pro Arg Pro Gln Ser Pro 275 280 285Ser Gln Tyr Pro Met Pro Pro Thr Thr Gln Pro Gln Arg Pro Gly Leu 290 295 300Thr Ser Asn Pro Ser Ser Gly Tyr Asn Pro Pro Gln Ile Leu Glu Pro305 310 315 320Pro Thr Thr Asn Gly Gln Gln Thr Gly Ser Gly Ser Asn Ser Pro His 325 330 335Ile Ser Ala Ala Met Gly Trp Gln Ser Pro His Asn Gly Leu Thr Gln 340 345 350His Gln Gln Ser Asp Tyr Ser Tyr Pro Asp Pro Asn Gly Gln Tyr Ala 355 360 365Thr Ala Asn Ala Ala Ala Met Tyr Tyr Gln Gln Pro Val Gln Arg Pro 370 375 380His Ser Thr Gly Pro Ile Asp Tyr Gln Gln Leu Arg Gly Ala Glu Met385 390 395 400Trp Ala Gln His Gln Gln 40536406PRTArtificial Sequencesynthesized 36Met Ala Met Gln His Ser His His His Pro Thr Gly Ser Thr Pro Glu1 5 10 15Arg Gln Met His Gln Leu Pro Gln Leu Thr Ala Arg Asn Leu Pro Glu 20 25 30Pro Pro Met Asp Arg Ser Gly Ser Pro His Gly Ser Glu His Ser Arg 35 40 45Tyr Ser Ala Pro Arg Ser His Met Asp Ser Val Pro Arg Ser Tyr Pro 50 55 60Ser Pro Val Pro Met Asn Gly Pro Pro Met Met Gln Ala His Ala Pro65 70 75 80Pro Gln His Gln His Gln His Gln His Gln His His Ala Gly Val Pro 85 90 95Ile Thr Met Ile Leu Pro Gly Gly Pro Pro Asp Met Asn Ala Gly Met 100 105 110His His Tyr Lys Pro Pro Gly Val Pro Val Glu Pro Gln Pro Ala Gln 115 120 125Gln Val Lys Ala Tyr Pro Cys Gly Thr Cys Gly Lys Arg Phe Ala Arg 130 135 140Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro145 150 155 160His Val Cys Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser 165 170 175Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His Met 180 185 190Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 195 200 205His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 210 215 220Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln225 230 235 240Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala 245 250 255Ala Leu Ala Ala Arg Ala Ser Val Lys Pro Gly Ser Thr Arg Ser Asp 260 265 270Gly Asp Ser Met Ser Asn Arg Gly Ser Pro Met Thr Thr Pro Ser Pro 275 280 285Ala Gln Arg Thr Leu Ser Met Ser Pro Ser Ala Asp Gln Met Gln Arg 290 295 300Ser Asn Ala Glu Phe Gly Tyr Met Gly Asn Thr Ser Leu Pro Val His305 310 315 320Leu Gln Arg Asp Met His Val Gly Ser Pro Ala Ser Thr Thr Ser Ala 325 330 335Gly Tyr Ser Asn Gly Val Arg Pro Thr Ser His Pro Thr Gly Tyr Gly 340 345 350Met Val Pro Pro Pro Thr Leu Glu Pro Asn Val Glu Gln His Ser Gly 355 360 365Pro Gly Ser Ala Gly Gly Ser Pro His Met Ser Thr Met Gly Trp Gln 370 375 380Ser Pro Ser His Val Ala Ser Pro Ser His Ser Asn Asn Gly Ser Ala385 390 395 400Tyr Met Tyr Pro Gly Ala 40537283PRTArtificial Sequencesynthesized 37Met Ala Pro Gly Val Gly Arg Asp Phe Asn Cys Ser Trp Glu His Cys1 5 10 15Gly Lys Ser Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile 20 25 30His Thr Asn Glu Arg Pro Tyr His Cys Thr Val Lys Asp Cys Asn Lys 35 40 45Ser Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr 50 55 60Gly Glu Lys Pro His Val Cys Asp His Glu Gly Cys His Lys Ala Phe65 70 75 80Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Lys 85 90 95Arg Pro Tyr Ile Cys Gln Glu Pro Thr Cys Glu Arg Ser Phe Cys Arg 100 105 110Lys Thr Thr Leu Thr Lys His Gln His Arg Ser His Pro Ser Gly Thr 115 120 125Met Thr Arg Pro Pro Ser Glu Asp Ala Met Ser Glu Gln Ser Tyr Gln 130 135 140Ala Pro Val Ala Ala Pro Ile Pro Asn Asp Gln Tyr Leu Leu Ala Gln145 150 155 160Gln Gln Tyr Tyr His Gln Pro Ser Thr Pro Ser Gln Glu Phe Tyr Pro 165 170 175Pro Gln Ser Leu Pro Val Thr His Ile Pro Val His Asp Thr Pro Pro 180 185 190Ile Met Thr Gln Ser Val Pro Val Thr Ser Pro Leu Asp Val Gln His 195 200 205Ala Gln Gln Gln Tyr Met Gln Gln Leu Met Gln Gln Arg Tyr Asp Thr 210 215 220Thr Asn Gln Ser Tyr Ile Pro Pro Gly Phe Gln Gln Gln Gln Gln Thr225 230 235 240Phe Val Pro Gln Pro Met Ala Glu Gly His

Pro Leu Met Ile Ser Tyr 245 250 255Asn Gln Asn Phe His Tyr Lys Gln Pro Thr Arg Ile Leu Asn Gln Pro 260 265 270Glu Gly Thr Asp Trp Gly Phe Leu Gly Val Gly 275 28038388PRTArtificial Sequencesynthesized 38Met Ser Gly His Leu Gln Ala Ala Arg Pro Tyr Gly Ser Pro Thr Ser1 5 10 15Met His Ala Ser Leu His Met Pro Glu Pro Asn Met Gly Pro Ser Gly 20 25 30Met Ala Phe Pro Ser Met Ala Pro Glu Leu Tyr Ala Pro Pro Gln Pro 35 40 45Leu Arg Ala Pro Asp Ala Thr Ser Gln Pro Ala Pro Lys Ala Tyr Ala 50 55 60Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg65 70 75 80His Glu Arg Ile His Thr Gly Val Arg Pro His Val Cys Glu Tyr Pro 85 90 95Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln 100 105 110Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys 115 120 125Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser 130 135 140Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe145 150 155 160Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr 165 170 175Val Glu Asp Ala Ala Arg Ala Thr Ala Glu Val Leu Ala Arg Asn Ser 180 185 190Val Ala Arg Ser Ala Ser Ala Arg Pro Thr Arg Ser Glu Gly Asp Gln 195 200 205Ile Ser Asn His Gly Ser Pro Leu Ser Thr Pro Ser Pro Ala Gln Arg 210 215 220Thr Met Ser Met Ser Pro Ser Ala Glu Leu Ala Ala Ala Asn Gly Met225 230 235 240Gln His Gln Tyr Asn Gly Asn Ser Ser Leu Pro Ala His Met Arg Thr 245 250 255Asp Leu His Ser Ser Ser Pro Ala Ala Thr Thr Ser Ser Gly Phe Ser 260 265 270Ser Asn Val Arg Pro Thr Ser His Pro Asn Ala Tyr Gly Ala Ala Pro 275 280 285Pro Pro Thr Thr Leu Glu Pro Ser Ile Glu Gly Ser Gln Gly Pro Gly 290 295 300Ser Ala Val Gly Ser Pro His Met Ser Ser Val Gly Trp Ala Ser Pro305 310 315 320Ser His Val Ala Ser Pro Ala His Ser Asn Ser Gly Gly Asn Ser Ser 325 330 335Tyr Val Tyr Pro Asp Pro Asp Ser Ser Tyr Pro Thr Asn Ala Ala Ala 340 345 350Gln Gly Gln Met Phe Tyr Ser Ala Ala Met Gly Leu Gln Arg Pro Gly 355 360 365Ser Ala Glu Pro Gly Ala Gln Ser Ala Tyr Lys Pro Arg Gln Asn Glu 370 375 380Leu Trp Ala Ala38539421PRTArtificial Sequencesynthesized 39Met Asp Ile Lys Glu Ile Val Asn Ser Lys Gly Val Lys Gly Ala Ala1 5 10 15Ala Ala Ala Ala Ala Ser Ala Ser Gly Gln Ala Gln Asp Leu His Leu 20 25 30Leu Gln Ser Ile Ser Gln Ala Asn Gly Leu Arg Met Ser Asp Ala Gly 35 40 45Ser Glu Arg Gly Asn Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser 50 55 60Thr Pro Arg Met Gly Met Asn Gly Met Asn Gly Ala Pro Asn Gly Met65 70 75 80Arg Tyr Pro Ser Pro Pro Gly Met Gln Asn Ser Met Pro Met Met Gln 85 90 95Gln Pro Tyr Arg Pro Asp Val Ala Phe Asp Asn Gly Met Met Ser Thr 100 105 110Gln Gln Gln Asp Asn Thr Arg Gln Arg Gln Pro Gly Asp Ile Thr Val 115 120 125Thr Lys Ala Phe Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg 130 135 140Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro His145 150 155 160Val Cys Asp Tyr Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala 165 170 175Leu Thr Val His Leu Arg Val His Thr Gly Glu Lys Pro His Thr Cys 180 185 190Glu Arg Cys Ala Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 195 200 205Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala 210 215 220Ala Ala Leu Ala Gly Arg Pro Gly Asn Asn Arg Pro Ser Arg Gln Arg225 230 235 240Ser Asp Gly Glu Ser Tyr Ser Asn Asn Gly Ser Pro Met Ser Thr Pro 245 250 255Ser Pro Gly Arg His Leu Ser Ala Ser Pro Ser Ser Asp Met Ala Pro 260 265 270Met Asn Asn Met Gln Arg His Pro Gly Asp Tyr Gly Tyr Met Asn Asn 275 280 285Ser Ser Leu Pro Gly His Leu Arg Gly Asp Tyr Gly Val Pro Asn Gln 290 295 300Pro Pro Pro Val Ser Thr Ala Phe Thr Asn Gly Met Gln Arg Pro Thr305 310 315 320Ser His Pro Thr Gly Tyr Gly Pro Pro Ser Ile Leu Glu Pro Pro Ala 325 330 335Asn Met Glu Gln Arg Gln Pro Gly Ser Ala Asn Gly Ser Pro His Met 340 345 350Thr Asn Met Gly Trp Gln Ser Pro Ser Gln Met Ala Ser Pro Ser His 355 360 365Asn Asn Asn Tyr Val Tyr Pro Asp Pro Asp Pro Tyr Gly Ser Gly Ala 370 375 380Ala Met Gly Gln Met Tyr Tyr Pro Asn Ser Asn Met Arg Arg Pro Gln385 390 395 400Ser Thr Glu Pro Glu Gln Tyr Asp Met Lys Pro Arg Ile Asn Glu Met 405 410 415Trp Ala Thr Ala Gln 42040441PRTArtificial Sequencesynthesized 40Met Asp Ile Thr Thr Ile Leu Asn Lys Asn Arg Ser Ala Val Ala Ala1 5 10 15Ala Ala Glu Ala Gln Leu Gln His Gln Leu Ala Gln Thr Ala Gln Ile 20 25 30Lys Ser Arg Ser Pro Ser Glu Leu Gly Ser Glu His Asp Ala Gln Gln 35 40 45Pro Gly Arg His Ser Glu Pro Tyr His Pro Ala His Gln Pro Ile Gln 50 55 60Leu Pro Thr Ile Ser Gln Tyr His Ser Pro Leu His Thr Asn His His65 70 75 80Ala Ser Met Met Arg Gly Asp Tyr Ala Gln Asn Gly His Glu Asn Met 85 90 95Phe Arg Asn Met Pro Thr Ser Asn Ser Gly Pro Gly Arg Gly Thr Gly 100 105 110Glu Pro Ala Pro Lys Ser Phe His Cys Gln Thr Cys Ser Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 130 135 140Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 180 185 190Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 195 200 205Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 210 215 220His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr225 230 235 240Glu Ala Asn Leu Arg Gln Gly Lys Val Val Arg Pro Asp Gly Val Tyr 245 250 255Ser Glu Thr Ala Ser Pro His Gly Thr Ala Ser Pro Ala Gln Arg Ser 260 265 270Ser Val Ser Pro Arg His Glu Leu Pro Pro Leu His Ser His Arg Gln 275 280 285Met Gly Asp Tyr Phe Met Ala Ser Ser Ser Leu Pro Pro His Leu Arg 290 295 300Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro Ser Thr Pro Ser Pro305 310 315 320Thr Leu Ser Thr Phe Ser Ala Ala His His Pro Arg Pro Ser Leu Thr 325 330 335Ser His Pro Thr Ser Tyr Gly Pro Pro Gln Pro Leu Glu Pro Pro Pro 340 345 350Asn Ser Gly Ser Arg Pro Gly Ser Val Thr Gly Ser Pro His Met Thr 355 360 365Thr Val Gly Trp Ala Ser Pro Ser Leu Asn Ser Val Pro Ser Pro Gly 370 375 380Ser Val Ser Ala Pro Glu Tyr Thr Tyr Pro Glu Pro Ser Gly Pro Pro385 390 395 400Phe Ala Gly Gly Met Pro Ala His Met Tyr Tyr Pro Asn Ser Thr Ile 405 410 415Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys 420 425 430Val Glu Glu Pro Trp Ala Thr His Ala 435 44041479PRTArtificial Sequencesynthesized 41Met Glu Leu Asp Thr Ile Leu Asn Ala Arg Leu Thr Ala Ser Leu Gly1 5 10 15Thr Gly Ala Pro Tyr Ala Met Gln His Ala Met Gln Gln Gln His Phe 20 25 30Gly Ala Pro Pro Ser Tyr Leu Asn Gly Ser His Ile Lys Ser Glu Asn 35 40 45Gly Ser Glu Arg Gly Val Ser Pro His Pro Ser Asp Ser Ser Arg Tyr 50 55 60Ser Ser Gln Gln Pro Gln Gln Gln Leu Pro Ser Tyr Pro Ser Ile Pro65 70 75 80Gln Gln His Met Asn Gly Leu Arg Tyr Pro Ser Pro Ser Gln Met Gln 85 90 95Ala Pro Met Pro Met Leu Asn Asn Ser Asn Tyr Ile Pro Thr Pro Pro 100 105 110Asp His Thr Tyr Ala Gln Gln Gln Gln Leu Pro Asp Ala Gln Val Gly 115 120 125His Gln His Asn Gly Gly Arg Pro Ala Ser Asp Thr Gly Pro Pro Lys 130 135 140Ala Phe Ala Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp145 150 155 160Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys 165 170 175Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr 180 185 190Val His Gln Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg 195 200 205Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg 210 215 220Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln225 230 235 240Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His 245 250 255Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala 260 265 270Ser Arg Ala Ser Gln Ser Ser Arg Thr Gly Arg Ser Asp Gly Gly Asp 275 280 285Tyr Ser Glu Thr Ala Ser Pro Leu Gly Thr Pro Ser Pro Asn Asp Arg 290 295 300Thr Leu Ser Leu Ser Pro Ala Asn Gly Met Pro Ala Gly Gly Met Pro305 310 315 320Gly Leu His Arg Gln Gly Ser Asp Tyr Ala Tyr Met Gly Gly Met Asn 325 330 335Val Pro Pro His Met Arg His Glu Met Pro Gln Pro Ser Pro Arg Ala 340 345 350Ser Pro Ala Leu Thr Ala Gln Ser Tyr Ala Ser Asn Val Ser Gly Ser 355 360 365Arg Pro Ala Ile Thr Ser His Pro Ser Ala Tyr Gly Pro Pro Pro Ile 370 375 380Leu Glu Pro Pro Ala Ser Ala Asn His Gly Gln Ser Gly Gly Thr Ser385 390 395 400Ser Ala Asn Gly Ser Pro His Met Ser Thr Met Gly Trp Gln Ser Pro 405 410 415Gly Gln Gln Ala Leu Pro Ser Pro Gly Ala Asn Asp Asn Gly Tyr Val 420 425 430Tyr Pro Glu Pro Gln Tyr Gln Ala Gln Asn Gly Met Tyr Tyr Gln His 435 440 445Asn Asn Ile Arg Arg Pro Asn Ser Thr Glu Pro Asp His Tyr Asn Pro 450 455 460Asn Gln Gln Arg Met Gly Asn Glu Met Trp Ala Pro Ala Val Gln465 470 47542449PRTArtificial Sequencesynthesized 42Met Arg Leu Ser Phe Ser Arg Ile Leu Thr Cys Ala Glu Pro Arg Ala1 5 10 15Gln Gln Pro Gln Gln Gly Ala Thr Pro Glu Leu Gln Gln Gln Arg Pro 20 25 30Gln Ala Leu Gln Gln Leu Gln Gln Gln Leu Gln Pro Leu Gln Thr Gln 35 40 45Ile Asp Arg Gln Pro Ser Pro His Gly Ser Glu Gln Ser Arg Tyr Ser 50 55 60Gly Pro Met Asn Ala Ser Tyr Pro Ser Pro Thr Ala Met Ala Ala Thr65 70 75 80Pro Leu Pro Pro Val Pro Asn Ala Asn Met Ala Pro Ala Pro Met Val 85 90 95Pro Asn Glu Met Gln Gln Asn Leu Gly Met Pro Pro Ala Gly Tyr Gln 100 105 110Pro Ala Gln Ala Pro Pro Gln Pro Pro Ala Lys Gln Phe Pro Cys Ser 115 120 125Thr Cys Gly Lys Pro Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu 130 135 140Arg Ile His Ser Gly Ile Arg Pro His Val Cys Asp Tyr Pro Gly Cys145 150 155 160Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Val 165 170 175His Thr Gly Glu Lys Pro His Arg Cys Glu Arg Cys Gly Lys Pro Phe 180 185 190Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys 195 200 205Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg 210 215 220Arg Thr Thr Leu Thr Arg His Gln Asn His His Val Gly Thr Val Glu225 230 235 240Glu Ser Ala Arg Ala Arg Ala Glu Ala Leu Ala Gln Gly Ala Asn Ala 245 250 255Ala Ala Ala Ala Val Ala Ala Ala Gln Ser Lys Ser Arg Ser Gly Ser 260 265 270Glu Gln Ala Ser Asn His Glu Ser Pro Leu Thr Asn Thr Pro Ser Pro 275 280 285Gly Gln Arg Pro Met Ser Met Ser Pro Gly Ala Glu Leu Ala Gly Ile 290 295 300Asn Asn Met Gln Tyr Leu Ser Asn Ser Ile Pro Pro His Leu Arg Gly305 310 315 320Asp Val His Val Gly Ser Pro Ser Pro Thr Ala Ser Ser Gly Tyr Asn 325 330 335Asn Gly Met Arg Pro Thr Ser His Pro Thr Gly Tyr Ala Pro Pro Gln 340 345 350Thr Leu Glu Pro Ser Ile Glu Gln Pro Gln Gln Gly Pro Gly Ser Ala 355 360 365Val Gly Ser Pro His Ile Gly Ser Val Gly Trp Ala Ser Pro Gly His 370 375 380Val Gly Ser Pro Thr Gln Ser Pro Ser Gly Asn Gly Tyr Val Tyr Pro385 390 395 400Asp Pro Glu Ala Tyr Pro Asn Gly Thr Pro Ile Ala Gln Met Phe Phe 405 410 415Asn Ser Ala Val Ala Ser Arg Arg Pro Asp Ser Ala Glu Pro Gly Asn 420 425 430Pro Ser Phe Asp Thr Lys Ser Arg Gln Gly Glu Leu Trp Thr Asn Ser 435 440 445Gln43517PRTArtificial Sequencesynthesized 43Met Asp Leu Arg Gly Leu Leu Gln Ser His Pro His His His Thr Ser1 5 10 15His Gln Gln Pro Tyr Asp His Arg Leu Pro Ala Ala Gln Pro Tyr Thr 20 25 30Ser Leu Pro Ile Ser Tyr Ala Ser Pro Ser Tyr Ile Ala Ile Gly His 35 40 45His His Asn His Gln His His Gln Ala Gln Gly Gln Gln Gln Gly Gln 50 55 60Gly Met Tyr Asp Phe Pro Phe Ser His Pro Gln Gln Gln Gln Gln Gln65 70 75 80Gly Glu Gln Ser Thr Tyr Leu Arg Arg His Gln Gly Tyr Gln Asn Gln 85 90 95Met Pro Thr Ser Ala Gln Gln Gln Gln Gln Ser Ser Tyr Pro Gln Gln 100 105 110Gln Gln Gln Leu Pro Arg Ser Tyr Gln Ser Gly Asn Ala Gln Ser Met 115 120 125Tyr Gly Lys Thr Thr Ala Ile Ala Pro Ala Gly Glu Gly Trp Gly Lys 130 135 140His Gln Gln Gln Val Gly Gly Tyr Gln Gln Ser Gln Met Gln Thr Gln145 150 155 160Val Val Ala Gln Ser Thr Asp Val Asp Ala Leu Met Arg Ala Ile Gln 165 170 175Ala Lys Pro Ala Gly Asp Asn Gly Ser Ala Ser Glu Val Ala Ser Ala 180 185 190Glu Arg Thr Arg Asp Val Ser Ala Glu Arg Glu Lys Asn Ala Ser Arg 195 200 205Gly Gly Gly Ala Thr Gly Met Lys Asn Gly Gly Asn Gly Arg Glu Glu 210 215 220Pro Lys Lys Arg Tyr Glu Cys His Leu Gly Glu Cys Arg Lys Ala Phe225 230

235 240Phe Gln Lys Thr His Leu Glu Ile His Ile Arg Ala His Thr Gly Ala 245 250 255Lys Pro Tyr Thr Cys Thr His Pro Thr Cys Thr His Ala Phe Ser Gln 260 265 270Leu Gly Asn Leu Lys Thr His Leu Arg Arg His Thr Gly Glu Arg Pro 275 280 285Phe Ala Cys Pro Thr Cys Gly Lys Thr Phe Ala Gln Arg Gly Asn Val 290 295 300Arg Ala His Ala Ala Val His Asp Ala Gly Gly Ala Ala Lys Lys Phe305 310 315 320Val Cys Arg Leu Asp Gly Cys Gly Lys Cys Phe Thr Gln Leu Gly Asn 325 330 335Leu Lys Ser His Met Asn Lys Phe His Val Glu Thr Leu Arg Gly Leu 340 345 350Thr Val Arg Phe Gly Glu Ser Glu Lys Arg Gly Arg Asp Gly Gly Glu 355 360 365Gly Glu Gly Lys Glu Glu Glu Asp Asp Leu Leu Asp Tyr Phe Arg Ser 370 375 380Leu Tyr Arg Asn Ala Asn Lys Gly Ile Lys Gly Arg Gly Lys Gly Arg385 390 395 400Lys Val Ala Ser Thr Thr Ser Thr Ser Ser Thr Pro Pro Ser Leu Ser 405 410 415Ser Ser Thr Ser Ser Leu Ser Ser Leu Ala Ser Leu Ser Ser Leu Ala 420 425 430Ser Leu Ala Ser Leu Ala Ser Pro Pro Leu Ser Pro Pro Thr Ser Thr 435 440 445Ser Ser Tyr Ile Gly Gly Ile Pro Ala His Tyr Arg Met Gly Met Gly 450 455 460Met Gly Met Ala Pro Gly Met Asp Gly Ile Glu Leu Phe Asp Gly Ser465 470 475 480Ser Ser Gly Ile Gly Ser Pro Cys Ala Ser Ser Leu Gly Ser Leu Tyr 485 490 495Glu Val Gly Gly Thr Tyr Glu Glu Glu Glu Gly Gly Glu Leu Ala Phe 500 505 510Gly Asp Arg Met Tyr 51544436PRTArtificial Sequencesynthesized 44Met Ser Gly Met Arg Ser Pro Ala Pro Thr Glu Val Met Asp Ile Thr1 5 10 15Asn Met Leu Asn Asn Lys Gly Gln Met Gln Gln Leu Thr Ser Gly Leu 20 25 30Leu Asp His Gln Gln Tyr Gln His Ala Phe Val Lys His Glu Ser Gly 35 40 45Met Glu Arg Ser Ala Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser 50 55 60Asn Pro His Ser Ile Ala Arg Ala Tyr Pro Ser Pro Ser Thr Met Gln65 70 75 80Ala Pro Met His Met Pro Asn Pro Met Ser Ala Ala Met Thr Met Gln 85 90 95Gly Tyr Pro Glu Met Pro Asn Met Gly Gly Met Pro His Met His Met 100 105 110Gln Gln Met Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Ile Lys 115 120 125Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp 130 135 140Leu Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro His Val Cys145 150 155 160Asp Trp Pro Gln Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr 165 170 175Val His Gln Arg Val His Thr Gly Glu Lys Pro His His Cys Glu Thr 180 185 190Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg 195 200 205Thr His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln 210 215 220Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His225 230 235 240Ser Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala 245 250 255Ala Ser Lys Ser Lys Gly Leu Ser Gln Thr Arg Ser Glu Ser Asp His 260 265 270Met Ser Asn His Gly Ser Pro Leu Thr Thr Pro Ser Pro Ser Gln Arg 275 280 285Thr Met Ser Met Ser Pro Ser Val Asp Leu Ser Gly Asn Asn Ser Ile 290 295 300Pro Arg His Pro Gly Asp Phe Gln Tyr Leu Ser Gln Asn Gly Ser Leu305 310 315 320Pro Met His Met Arg Val Gly Ser Pro Thr Ser Thr Ser Ser Gly Gly 325 330 335Phe Asn Met Met Arg Pro Thr Ser His Pro Thr Ser Tyr Gly Pro Pro 340 345 350Pro Thr Leu Glu Pro Asn Leu Asp Asn Ser Gln Gly Thr Pro Ser Ser 355 360 365Asn Gly Gly Ser Pro His Met Thr Asn Val Gly Trp Gln Ser Pro Ser 370 375 380His Met Ala Ser Pro Ser Gln Asn Asn Ala Ser Tyr Val Tyr Pro Asp385 390 395 400Pro Ala Asp Ala Tyr Pro Ala Asn Gln Ala Met Asn Gln Met Tyr Tyr 405 410 415Ser Ala Ala Ala His Met Arg Arg Pro Gln Ser Thr Glu Pro Gly Leu 420 425 430Val His Met Ala 43545507PRTArtificial Sequencesynthesized 45Met Leu Ala Arg Pro Glu Arg Arg Gly Lys Pro Arg Cys Gly Ala Gly1 5 10 15Ser Ala Leu Lys Pro Glu Gly Val Lys Leu Ser Phe Asp Cys Leu Phe 20 25 30Phe Gly Ile Glu Thr Ile Ser Glu Pro Glu Val Thr Pro Ala Phe Val 35 40 45Ala His Ile Leu Gly Cys Glu Ser Leu Glu Thr Ser Pro Ala Val Val 50 55 60Asn Phe Ser Ala Asp Pro Thr Arg Lys Gly Ser Ala Ala Met Val Ala65 70 75 80Ala Glu Phe Asp His Gln Gln Phe Ile Gln Asn Pro His Leu Asp Thr 85 90 95Ser Ser Pro Lys Met Lys Pro Glu Pro Gly Val Ser Glu Ala Gly Asp 100 105 110Gln Pro Val Leu Ala Tyr Pro Pro His Ala Pro Leu Gly Gln Val Pro 115 120 125Asn Met His Pro Asp Met Arg Tyr Gln Pro Gln Thr His Pro Asn Pro 130 135 140Ala Leu Pro Leu Leu Gln Asn Pro Tyr Met Pro Gly Gly Tyr Thr Ser145 150 155 160Ala Pro Pro Met Pro Asn Gly Gly Ala Pro Gln Gly Arg Thr Asp Pro 165 170 175Pro Pro Lys Thr Phe His Cys Gly Thr Cys Ser Lys Gly Phe Ala Arg 180 185 190Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro 195 200 205His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser 210 215 220Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys Pro His Met225 230 235 240Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 245 250 255His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 260 265 270Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln 275 280 285Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala 290 295 300Asn Leu Arg Gln Asn Lys Glu Arg Val Arg Ala Pro Gly Glu Gly Met305 310 315 320Tyr Ser Glu His Gly Ser Val His Ser Thr Pro Ser Pro Ala His His 325 330 335Pro Ala Leu Ser Pro Ala Gly Glu Leu Pro Pro Leu Asn Met Pro Arg 340 345 350Ser Ser Gly Glu Tyr Tyr Ser Met Gly Asn Gly Ser Ile Pro Pro His 355 360 365Val Arg Gly Asp Phe Pro Gln Ala Ser Pro Arg Ala Ser Pro Thr Ala 370 375 380Thr Ser Pro Ser Leu Ser Ser Phe Gly Ser Ala Pro His Thr Arg Pro385 390 395 400Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu Glu 405 410 415Pro Pro Ala Asn Asn Asp His Arg Pro Asn Ser Val Ser Gly Ser Pro 420 425 430His Met Thr Ser Leu Gly Trp Ala Ser Pro Ser His Gly Ser Ile Pro 435 440 445Ser Pro Gly Ser Ala Thr Asp Phe Gly Tyr Ser Asp Pro Asn Gly Pro 450 455 460Ala Tyr Pro Asn Ser Met Pro Pro His Met Tyr Phe Pro Asn Ser Thr465 470 475 480Ile Arg Arg Pro Thr Ser Thr Glu Pro Glu Asn Tyr Glu Met Lys Pro 485 490 495Lys Ile Gly Glu Ser Ala Trp Ser Thr Pro Val 500 50546529PRTArtificial Sequencesynthesized 46Met Ser His Thr Ser Gly Asn Ala Trp Arg Trp Ser Glu Asp Ser His1 5 10 15Ile Pro Phe Cys Tyr Met Asp Thr Ala Gly Met Val Gln Ser Met Asn 20 25 30Pro Gln Thr Thr Thr Ser Ala Gly Leu Gly Arg Ala Thr Val Ala Ala 35 40 45Pro Ile Met Pro Ile Ser Ser Tyr Gly Ser Ser Thr Phe Asn Met Thr 50 55 60Ser Gly His Gln Gln Ile Pro Gln Asn Ser Tyr Gly Phe Thr Ser Tyr65 70 75 80Asn Asp Gly Ser Leu Thr Thr Ile Ile Pro Ser Tyr Gly Ala Asn Tyr 85 90 95Ile Gln Pro Arg Pro Leu Pro Gly Met Met Gln Ser Phe Ala Pro Thr 100 105 110Pro Lys Gln Ala Pro Phe Asn Gly Ser Ser Arg Gln Glu Phe Val Gly 115 120 125Ser Ser His Gln Asn Gln Ser Pro Gln Ile Lys Pro Glu Pro Ser Trp 130 135 140Thr Thr Ser Ala Gly His Lys Thr Pro Pro Lys Thr Gln Ser Thr Pro145 150 155 160Pro Pro Ser Lys Asp Ile Ser Pro Leu Pro Leu Thr Gly Ser Asp Glu 165 170 175Ala His Ile Gly Ser Thr Ala Ile Asp Arg Leu Met Lys Val Ile Gln 180 185 190Thr Lys Ala Gln Thr Leu Gln Thr Gln Leu Pro Pro Ile Pro Gln Ile 195 200 205Thr Pro Val Val Gly Ala Pro His Thr Leu Ser Arg Gln Asp Ser Met 210 215 220Tyr Arg Arg Phe Tyr Gly Tyr Glu Lys Glu Glu Lys Gln Met Leu Thr225 230 235 240Ser Gly Lys Ala Pro Ser Glu Pro Gly His Ser Lys Arg Lys Glu Lys 245 250 255Lys Tyr Arg Cys Thr Phe Glu Asn Cys Pro Ser Ser Phe Pro Gln Lys 260 265 270Thr His Leu Gln Ile His Leu Arg Lys His Thr Gly Ala Lys Pro Tyr 275 280 285Thr Cys Ser Trp Lys Ser Cys Gly Arg Gln Phe Ser Gln His Gly Asn 290 295 300Leu Lys Thr His Met Asn Arg His Ser Gly Glu Arg Arg Phe Pro Cys305 310 315 320Glu Ile Cys Gly Lys Arg Phe Gly Gln Pro Ser Asn Leu Ser Ala His 325 330 335Arg Ile Val His Thr Gly Glu Lys Pro Phe Thr Cys Lys Leu Asp Gly 340 345 350Cys Glu Lys Arg Phe Thr Gln Leu Gly Asn Leu Lys Ser His His Asn 355 360 365Asn Phe His Gln Gln Thr Ile Glu Asn Leu Met Leu Lys Leu Glu Ser 370 375 380Gly Glu Ile Asp Leu Glu Ala Asn Lys Glu Phe Trp Ser Tyr Phe Phe385 390 395 400Thr Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp 405 410 415Arg Asn Ile Ser Pro Arg Ser Arg Leu Ser Lys Ser Gly His Ala Ser 420 425 430Thr Gly Thr Asp Ala Ser Arg Tyr Ile Ser Ser Asn Met Arg Ser Cys 435 440 445His Gly Leu Met Gly Val Asp Ala Thr Ser Pro Phe Ser Ser Asp Val 450 455 460Thr Met Tyr Asp Ser Asp Ala Ser Leu Arg Ser His Thr Ser Gly Ser465 470 475 480Ile Ser Ala His Ser Ser Phe Gly Ser Val Ser Ser Asp Gly Thr Ser 485 490 495Ser Ser Cys Ser Ser Phe Ser Asp Glu Ile Thr Gly Asp Tyr Lys Asp 500 505 510His Arg Gly Gly Asn Ser Arg Gly Gly Leu Ala Phe Gly Glu Arg Leu 515 520 525Tyr47423PRTArtificial Sequencesynthesized 47Met Asp Ile Pro Thr Ile Leu Asn Glu Lys Gly Thr Ala Ala Ala Ala1 5 10 15Ala Ala Ala Ala Ala Ala Ala Lys Ala Gln Leu Gln Gln Gln Leu Ala 20 25 30Gln Gly Thr His Ile Lys Ser Gln Ser Pro Ser Glu Met Gly Ser Glu 35 40 45Asn Gly Thr Ser Gln Asn Gly Asp Gln Pro Asn Ile Tyr Asn Pro Thr 50 55 60Ser Gln Pro Gln Pro Leu Ser Thr Ile Pro Gln Tyr His Ser Pro Pro65 70 75 80Gln Ser Ser Val Val Asn Ser Ala Ala Arg Ser Asp Tyr Ile Gln Asn 85 90 95Asp Gln Gly Lys Ile Glu Tyr Leu Gln Asn Asp Ser Ser Gly Arg Thr 100 105 110Arg Ala Asn Gly Glu Pro Ala Pro Lys Thr Phe His Cys Ser Thr Cys 115 120 125Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile 130 135 140His Ser Gly Ile Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys145 150 155 160Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr 165 170 175Gly Glu Lys Pro His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp 180 185 190Ser Ser Ser Leu Ala Asp Ile Ala Glu Tyr Ile Pro Glu Asn Asp Leu 195 200 205Thr Asn Ala Gln Ala Ala Ala Gln Thr Glu Ala Asn Leu Arg Gln Asn 210 215 220Lys Glu Arg Ser Ile Arg Pro Leu Glu Gly Ile Tyr Ser Glu Pro Gly225 230 235 240Ser Ala Gln Ser Thr Pro Ser Cys Gln Arg Leu Ser Ala Ser Pro Gly 245 250 255Asn Glu Leu Pro Pro Met His Leu His Arg Gln Met Gly Glu Tyr Tyr 260 265 270Met Gly Asn Asn Thr Ser Ile Pro Pro His Leu Arg Ser Asp Phe Gln 275 280 285Gln Ala Ser Pro Arg Ala Ser Pro Ser Thr Ser Ser Pro Pro Leu Ser 290 295 300Thr Tyr Asn Ser Val Pro His Ile Arg Pro Ser Leu Thr Ser His Pro305 310 315 320Ser Gly Tyr Arg Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Ser Asp 325 330 335Pro Arg Pro Asn Ser Val Ala Gly Ser Pro His Ile Ser Ser Met Gly 340 345 350Trp Ala Ser Pro Thr Leu Asn Ser Ile Ser Ser Pro Gly Ser Ala Ser 355 360 365Ala Thr Glu Tyr Ser Tyr Pro Glu Pro Ser Leu Pro Pro Tyr Ser Ala 370 375 380His Ile Pro Pro His Ile Phe Phe Pro Asn Ser Thr Ile Arg Arg Pro385 390 395 400Gln Ser Thr Glu Pro Glu Asn Tyr Glu Met Lys Pro Lys Leu Asn Gly 405 410 415Asp Ser Trp Thr Thr Pro Val 42048421PRTArtificial Sequencesynthesized 48Met Asn Arg Pro Glu Gln Gln Gln Gln Tyr Asn Gln Tyr Gln Gln Gln1 5 10 15Gln Gln Gln Phe Arg Gln Pro Gln Leu Pro Tyr Asn Asp Tyr Gln Gln 20 25 30His Gln Gln His Gln Gln Gln Gln Gln Pro Gln Gln Tyr Gln Gln Tyr 35 40 45Gln Gln Tyr Gln Gln Thr Pro Gln Gln Phe His Pro Gln Tyr Asn Ile 50 55 60Ser Pro Ser Thr Gln His Ser His Ile Ser Pro Thr Ser Ser Gln Tyr65 70 75 80Ser Asn Thr Ser Glu Gly Gln Arg Leu Lys Ser Ala Gln Asp Thr Val 85 90 95Thr Thr Asp Asp Gly Arg Pro Leu Leu Gly Ala Thr Lys Val Asp Gln 100 105 110Leu Met Leu Val Ile Gln Ala Arg Lys Lys Gly Val His Asn Pro Ile 115 120 125Ala Gln Ala Asp Asp Gly Ser Ile Leu Asp Asn Gly Asp Gly Val Leu 130 135 140Pro Gln Glu Thr Glu Leu Val Gly Gly Ile Asp Lys Pro Lys Thr Lys145 150 155 160Gly Thr Lys His His Glu Cys Gln Tyr Cys His Lys Thr Phe Thr Gln 165 170 175Ser Thr His Leu Glu Val His Val Arg Ser His Ile Gly Tyr Lys Pro 180 185 190Phe Glu Cys Asn Tyr Cys Gly Lys Arg Phe Thr Gln Gly Gly Asn Leu 195 200 205Arg Thr His Leu Arg Leu His Thr Gly Glu Lys Pro Tyr Ile Cys Glu 210 215 220Thr Cys Gly Arg Ser Phe Ser Arg Lys Gly Asn Leu Ala Ala His Lys225 230 235 240Leu Thr His Glu Asn Leu Lys Pro Tyr Glu Cys Lys Leu Asp Gly Cys 245 250 255Asn Lys Ala Phe Thr Gln Leu Gly Asn Leu Lys Ala His Gln Asn Arg 260 265

270Phe His Leu Glu Thr Leu Asn Asn Leu Thr Arg Arg Leu Ala Glu Ile 275 280 285Asp Pro Glu Asp Ala Gln Thr Thr Met Asn Pro Asp Glu Arg Asp Leu 290 295 300Leu Asn Tyr Phe Ala Gly Leu Tyr Lys Asn Ser Asn Arg Gly Ile Lys305 310 315 320Gly Arg Gly Lys Arg Thr Ser Pro Val Leu Lys Thr Pro Gln Ile Ala 325 330 335Asn Gln Ala Ala Pro Val Asn Asn Gln Pro Gln Pro Gln Gln Gln Gln 340 345 350Gln Gln Gln Gln Arg Pro Gln Gln Gln Gln Ala Lys Gln Glu Gln Gln 355 360 365Gln Gln Tyr Asn Pro Gln Tyr Gln Gln Tyr Gln Tyr Pro Gln Asp Gln 370 375 380Ser Phe Asn Gln Gln Leu Ala Phe Asn Gln Gln Asn Gly Ala Asn Phe385 390 395 400Ala Pro Pro Met Asn Pro Gly Ala Lys Ala Gly Asn Ile Ser Phe Lys 405 410 415Asn Val Asn Tyr Asn 42049383PRTArtificial Sequencesynthesized 49Met Asp Arg Ser Ala Ser Pro His Met Ser Glu His Ser Ser Tyr Ser1 5 10 15Ala His Ser Leu Ser Arg Ala Tyr Pro Ser Pro Thr Ala Met Gln Ala 20 25 30Pro Met Gln Ile Gln Asn Pro Met His Ser Ala Met Gln Met Gly Gly 35 40 45Phe Ala Asp Met Ser Gly Met Gly Ser Val Pro Ser Met Ala Met His 50 55 60His Ile Pro Gln Gln Pro Pro Gln Gln Gln Thr Pro Thr Ala Pro Val65 70 75 80Lys Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser 85 90 95Asp Leu Ala Arg His Glu Arg Ile His Thr Gly Val Arg Pro His Val 100 105 110Cys Asp Tyr Pro Lys Cys Asn Lys Gln Phe Ile Gln Arg Ser Ala Leu 115 120 125Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His His Cys Glu 130 135 140Thr Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg145 150 155 160Arg Thr His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys 165 170 175Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His 180 185 190His Thr Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu 195 200 205Ala Ala Ser Arg Ala Lys Asn Gly Ser Gln Ala Arg Ser Glu Gly Asp 210 215 220His Met Ser Asn His Gly Ser Pro Leu Thr Thr Pro Ser Pro Ser Gln225 230 235 240His Thr Met Met Ser Pro Ala Leu Asp Leu Ser Gly Ser Asn Gly Leu 245 250 255Asn Arg His Pro Ala Asp Phe Gln Tyr Met Thr Gln Gly Gly Thr Leu 260 265 270Pro Pro His Leu Arg Val Gly Ser Pro Thr Ser Thr Thr Ser Ala Ala 275 280 285Ser Tyr Asn Asn Gly Ile Arg Pro Thr Ser His Pro Thr Gly Tyr Gly 290 295 300Pro Pro Pro Thr Leu Glu Pro Asn Leu Glu Gln His Pro Ala Gly Ser305 310 315 320Gly Ser Ala Gly Gly Ser Pro His Met Ser Gln Val Gly Trp Gln Ser 325 330 335Pro Gln Thr His Ser Pro Ala His Asn Ala Gly Ser Tyr Val Tyr Pro 340 345 350Asp Pro Asp Gly Tyr Pro Pro Asn Pro Ser Met Ser Gln Met Tyr Tyr 355 360 365Gly Ala Pro Gln Gln Met Arg Arg Pro Gln Ser Thr Glu Pro Gly 370 375 38050507PRTArtificial Sequencesynthesized 50Met Ala Leu Thr Ala Gln Pro Ser Ala Pro Ala Gly Trp Glu Arg Trp1 5 10 15Pro Gln His His Pro Asn Asn Asp Tyr Val Met Met Asp Ala Asp Val 20 25 30Met Pro Tyr Asn Ala Arg Pro Met Thr Thr Ala Pro Met Gln Gln Arg 35 40 45Pro Ser Leu Val Pro His Tyr Ile Pro Thr Thr Ser Met Ser Thr Ala 50 55 60Pro Ile Thr Ser Ile Ser Ala Pro Ala His Tyr Gln Pro Ser Val Ser65 70 75 80Tyr Gly Gly Gly Tyr Pro Ala Tyr Pro Leu Pro Ser Pro Thr Thr Met 85 90 95Ser Ser Gln Tyr Arg His Gln His Tyr Gln Glu Arg Pro Ser Leu His 100 105 110Met Ile Thr Pro Glu Leu Glu Asp Thr Arg Gly Pro His His Ile Arg 115 120 125Asp Ala Arg Arg Tyr Ser Glu Glu Ser Arg Ser Pro Ser Glu Arg Ser 130 135 140Asp Ser Gln Ala Ser Thr Ala Glu Thr Thr Ile Ser Asn His Ser Thr145 150 155 160Cys Ser Arg Thr Ile Thr Pro Asn Ala Pro Val Asn Gly Ala Pro Gln 165 170 175Val Glu Phe Ser Thr Ala Val Asp Lys Leu Met Lys Val Ile Gln Ser 180 185 190Lys Met Lys Asp Thr Asp Ala Glu Gln Ser Gly Asp Asp Lys Asp Ile 195 200 205Lys Val Glu Gln Gln Ser Ser Pro Asp Cys Gln Ala Arg Val Gln Gln 210 215 220Pro Ala Asp Lys Gln Lys Arg Lys Arg Tyr Glu Cys Gln Ile Glu Gly225 230 235 240Cys Asn Lys Lys Phe Ser Gln Lys Thr His Arg Asp Thr His Val Arg 245 250 255Ser His Thr Gly Asp Arg Pro Tyr Val Cys Pro Ile Pro Gly Cys Gly 260 265 270Gly Arg Phe Thr Gln Ala Gly Asn Leu Lys Thr His Lys Arg Arg His 275 280 285Thr Gly Glu Arg Pro Tyr Arg Cys Glu Val Cys Asp Lys Gly Phe Val 290 295 300Gln Arg Gly Asp Val Lys Ala His Met Lys Thr His Leu Gly Thr Lys305 310 315 320Ala Phe Leu Cys Arg Leu Asp Asn Cys His Lys Gln Phe Thr Gln Arg 325 330 335Gly Asn Leu Lys Tyr His Gln Asn Lys Tyr His Asn Glu Thr Ile Lys 340 345 350Ala Leu Ala Ala Arg Phe Asp Thr Ile Glu Asp Trp Ser Thr Val Ser 355 360 365Lys Glu Asp Met Glu Ile Phe Lys Asp Phe Ala Val Val His Lys Asn 370 375 380Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys His Arg Lys Val Lys Ser385 390 395 400Val Pro Gln Ser Ser Pro Thr Ser Pro Thr Gly His Ser Pro Leu Pro 405 410 415Asn Ile Met Ala Ser Gln Tyr Pro Leu Pro Ser Gly Pro Gly Leu Ser 420 425 430His Leu Leu His Ser Pro His Pro Leu His Pro Pro Leu His His Gln 435 440 445Gly Pro Ser His Ser Ala Met Tyr Gly Met Pro Arg Pro Gly Phe His 450 455 460Gly His Tyr Glu Thr Tyr Asp His His Glu Val Asp Thr Val Ala Ser465 470 475 480Ser Arg Gly Ser Val Ala Glu Pro Ile Tyr His His His Glu Glu His 485 490 495Pro Arg Glu Leu Ala Phe Gly Asp Arg Ile Tyr 500 50551590PRTArtificial Sequencesynthesized 51Met Val Met Val Pro His Thr Leu Gly Thr Thr Trp Arg Trp Ser Glu1 5 10 15Asp Ser His Ile Pro Phe Cys Tyr Met Asp Ala Ser Gly Met Val Gln 20 25 30Ser Leu Asp Pro Gln Thr Thr Ser Ser Ala Gly Leu Gly Arg Thr Ile 35 40 45Ile Ala Pro Pro Ile Met Pro Met Asp Ser Phe Ser Gly Ser Ser Phe 50 55 60Ile Met Asn Gly His Gln Gln Ile Ser Gln Asn Ala Tyr Gly Phe Thr65 70 75 80Ser Tyr Thr Asn Gly Ser Ser Thr Asn Leu Ile Thr Thr Tyr Gly Ala 85 90 95Asn Tyr Ile Gln Pro Arg Ser Leu Pro Pro Met Ile Gln Ser Phe Ser 100 105 110His Ser Pro Lys Glu Val Ile Phe Asp Glu Ser His Arg Gln Gly Phe 115 120 125Ile Glu Ser Thr Ser Pro Ser Gln Ser Pro Gln Ile Lys Pro Glu Pro 130 135 140Ser Trp Lys Lys Thr Thr Arg Cys Gln Pro Glu Lys Thr Pro Lys Ala145 150 155 160Ser Arg Pro Asn Lys Thr Ile Asn Pro Pro Pro Leu Thr Gly Ser Asn 165 170 175Glu Ala His Ile Gly Thr Thr Ala Val Asp Arg Leu Met Lys Ile Ile 180 185 190Gln Asp Lys Ala Arg Thr Ser Lys Ser Pro Ser Pro Ser Val Ser Glu 195 200 205Ser Thr Ser Val Val Gly Ser Pro His Thr Leu Tyr Asn His Asp Tyr 210 215 220Ile Ser Ala Tyr Glu Glu Glu Lys Gln Ile Leu Thr Ser Val Lys Val225 230 235 240His Asp Glu Ser Gly Arg Ser Lys Val Pro Lys Lys Arg Phe Arg Cys 245 250 255Thr Phe Glu Gly Cys Met Ser Arg Phe Leu Gln Lys Ala Gln Leu Glu 260 265 270Ile His Val Arg Lys His Thr Gly Glu Thr Pro Tyr Val Cys Gly Tyr 275 280 285Val Gln Cys Lys Arg Arg Phe Thr Gln Gln Gly Asn Leu Asn Ile His 290 295 300Leu Asp Arg His Arg Gly Ile Arg Arg Tyr Pro Cys Glu Ile Cys Gly305 310 315 320Lys Arg Phe Gly Gln Arg Ser Asn Leu Asp Ala His Arg Ile Val His 325 330 335Thr Gly Ile Lys Pro Phe Ser Cys Lys Leu Asp Gly Cys Gly Lys Arg 340 345 350Phe Thr Gln Arg Gly Asn Leu Lys Ser His His Asn Lys Phe His Arg 355 360 365Gln Thr Leu Glu Arg Leu Gln Ser Gln Leu Ile Asn Gly Glu Ile Asp 370 375 380Ile Glu Ala Asn Lys Glu Phe Trp Ser Tyr Phe Phe Asn Leu Tyr Lys385 390 395 400Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Asn Ile Ser 405 410 415Pro Arg Ser Arg Ser Ser Arg Asn Ser His Ala Ser Thr Gly Ser Asn 420 425 430Ala Ser Arg Tyr Val Ser Pro Asn Met Arg Ser Cys His Gly Leu Met 435 440 445Asp Thr Asp Gly Ala Ser Tyr Ser Asp Ala Thr Met Tyr Asp Ser Asp 450 455 460Gly Ser Met Arg Ser His Thr Ser Gly Ser Met Ser Val Asn Ser Ser465 470 475 480Phe Ser Ser Gly Thr Thr Asp Ser Thr Ala Ser Thr Tyr Ser Asn Phe 485 490 495Ser Asp Asp Ile Ala Thr Asp Tyr Gln Asp Pro His Ala Arg Asn Val 500 505 510Arg Gly Asp Leu Ala Phe Arg Val Thr Arg Asp Val Glu Met Lys Met 515 520 525Ser Thr Gln Asp Glu Asn Thr Glu Met Lys Gly Arg Thr Ala Val Leu 530 535 540His Ser Phe Ile Ile Ile Ile Ile Ile Ile Thr Ile Ile Thr Gln His545 550 555 560Ser Thr Thr Pro Asn Thr Asn Ile Pro Pro Lys Lys Ala Arg Cys Ile 565 570 575Phe Ile Glu Arg Ile Asn Leu Phe Leu Thr His Gln Ser Ser 580 585 59052320PRTArtificial Sequencesynthesized 52Met Ala Pro Gly Gly Ser Arg Gly Phe Asn Cys Ser Trp Glu Arg Cys1 5 10 15Gly Lys Ser Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile 20 25 30His Thr Asn Glu Arg Pro Tyr His Cys Thr Val Pro Ser Cys Asn Lys 35 40 45Ser Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr 50 55 60Gly Glu Lys Pro His Val Cys Asp His Glu Asp Cys Arg Lys Ala Phe65 70 75 80Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Arg 85 90 95Arg Pro Tyr Ile Cys Ser Glu Pro Ala Cys Asp Arg Ser Phe Cys Arg 100 105 110Lys Thr Thr Leu Thr Lys His Gln Ser Arg Thr His Gln Pro Gly Gly 115 120 125Asn Thr Arg Pro Ser Ser Glu Glu Ala Pro Thr Pro Glu Ser Met Thr 130 135 140Tyr Gln Thr Pro Val Ile Thr Thr Met Ala Pro Asn Thr Thr Gln Tyr145 150 155 160Ile Ile Ala Gln Gln Pro Tyr Tyr His Asn Gly Pro Thr Pro Thr Thr 165 170 175Ala Asp Phe Tyr Gln Thr Pro Gln Pro Ala Ile His Phe Thr Gln Pro 180 185 190Gln Ala Met Val Pro Gln Gln Ile Pro Thr Ala Gly Leu Pro Thr Pro 195 200 205Pro Phe Glu Pro Gln His Tyr Ala Gln Ile Met Gln Gln Gln Gln Gln 210 215 220Pro Arg Tyr Asp Pro Thr Pro His Gln Thr Tyr Ile Gln Pro Gln Tyr225 230 235 240Gln Ser Pro Thr Pro Pro Phe Val Ala Gln His Gln His His Met Ala 245 250 255Ala Asp Val Arg Pro Leu Met Ala Thr Tyr His Pro Asp Gln Phe Lys 260 265 270Pro Pro Ala Arg Ile Leu Ser Ser Gln Glu Gly Thr Asp Trp Ser Phe 275 280 285Leu Gly Cys Leu Asp Arg Cys Ser Pro Gly Pro Gly Thr Gln Glu Tyr 290 295 300Ala Ile Pro Phe Ser Val Asp Glu Lys Gln Pro Leu Leu Gly Leu Ser305 310 315 32053426PRTArtificial Sequencesynthesized 53Met Val Ala Ala Asp Gly His Phe Asp His Gln His Leu Val Pro Asn1 5 10 15Pro Gly Leu Asp His Thr Ser Ser Pro Lys Met Lys Ser Glu Pro Gly 20 25 30Val Ser Asp Ala Gly Asp Gln Ala Val Leu Ala Tyr Pro Pro His Gly 35 40 45Pro Leu Gly Gln Val Pro Asn Met Ala His Asp Met Arg Tyr Ala His 50 55 60Gln Ala His Pro Gly Pro Gly Leu Pro Leu Leu Gln Asn Pro Phe Val65 70 75 80Pro Gly Ala Tyr Ala Gly Asn Ala Gln Ile Pro Asn Ala Gly Ala Pro 85 90 95Gln Gly Arg Pro Asp Pro Pro Pro Lys Thr Phe His Cys Gly Thr Cys 100 105 110Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile 115 120 125His Ser Gly Ile Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys 130 135 140Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr145 150 155 160Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp 165 170 175Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro 180 185 190Tyr Lys Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr 195 200 205Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala 210 215 220Ala Ala Glu Thr Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Arg225 230 235 240Met Pro Gly Asp Met Phe Ser Glu His Gly Ser Val His Ser Thr Pro 245 250 255Ser Pro Ala His His Pro Ile Ser Pro Ala Gly Asp Leu Pro Pro Leu 260 265 270Asn Met Pro Arg Ser Asp Tyr Tyr Met Pro Asn Gly Ser Ile Pro Pro 275 280 285His Val Arg Gly Gly Phe Thr Gln Ala Ser Pro Arg Ala Ser Pro Thr 290 295 300Ala Thr Ser Pro Ser Leu Ser Ser Tyr Gly Ser Ala Pro His Pro Arg305 310 315 320Pro Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu 325 330 335Glu Pro Pro Ala Asn Asn Asp His Arg Pro Asn Ser Val Ser Gly Ser 340 345 350Pro His Met Thr Ser Leu Gly Trp Pro Ser Pro Ser His Ala Ser Ile 355 360 365Pro Ser Pro Gly Ser Ala Thr Asp Phe Tyr Pro Glu Thr Ser Gly Pro 370 375 380Ala Tyr Pro Ser Ala Met Pro Pro His Met Tyr Phe Pro Asn Ser Thr385 390 395 400Ile Arg Arg Pro Thr Ser Thr Glu Pro Asp Ser Tyr Asp Leu Lys His 405 410 415Lys Met Glu Ser Ala Trp Ser Thr Pro Val 420 42554312PRTArtificial Sequencesynthesized 54Met Val Arg Arg Arg Phe Pro Arg Thr Lys Val Asp Ala Thr Cys Asp1 5 10 15Gln Cys His Lys Ser Phe Gly Ser Leu Ala Asp Leu Lys Arg His Ser 20 25 30Met Ile Gln Asp His Leu Asp Leu Arg Pro Tyr Ala Cys Thr Trp Pro 35 40 45Gly Cys Thr Arg Ala Phe Pro Gln Ser Ala Ala Leu Lys Asn His Phe 50 55 60Asn

Thr His Thr Gly Lys Lys Pro Tyr Arg Cys Ala Trp Val His Glu65 70 75 80Cys Asp Arg Ala Phe Gly Asp Lys Ser Thr Cys Ser Arg His Glu Ala 85 90 95Thr Lys His Leu Gly Leu Ile Gly His Lys Cys Pro Val Lys His Cys 100 105 110Arg Ser Ser Ile Lys Arg Lys Thr Asp Phe Ala Arg His Leu Arg Asp 115 120 125Lys His Gly Ile Arg Thr Lys Gly Leu Asp Val Ser Gln Tyr Ala Val 130 135 140Tyr Lys Pro Gly Gly Gly Pro Ile Lys Lys Cys Arg Lys Asn Lys Arg145 150 155 160Val Glu Ser Ser Pro Glu Asn Ser Pro Leu Ala Cys Pro Leu Asp Asp 165 170 175Phe Val Glu Ser Pro Thr Ser Ser Gly Thr Thr Thr Pro Leu Pro Glu 180 185 190Thr Pro Glu Met Gly Gln Gln Ala Glu Leu Pro Val Thr Asp Phe Ser 195 200 205His Met Gly Leu Val Val Pro Ala Asp Glu Pro His His Ser Gln Ile 210 215 220Ser Asn Ala Pro Phe Val Asp Thr Tyr Glu Lys His Asn Tyr Val His225 230 235 240Ser Leu Pro Thr Gln Phe Met Ile Pro Pro Ser Ile Ser Pro Ala Val 245 250 255Gln Pro Gln Tyr Tyr Tyr Val Pro Glu Ala Tyr Gln Gln Thr Phe Ala 260 265 270Ser Asp Pro Leu Ala Leu Val Ile Asp Pro Val Leu Met Met Glu Ser 275 280 285Met Leu Tyr Gly Gly His Gly Thr Gln His Tyr Ala Asn Ala Pro Ile 290 295 300Pro Leu Tyr Tyr Pro Ser Ser Cys305 31055454PRTArtificial Sequencesynthesized 55Met Glu Thr Ala Val Pro Val Thr Tyr Asn Val Thr Asn His Asp Met1 5 10 15Asn Ala Val Ala His Arg Arg Met Met Ala Pro His Gln His His His 20 25 30His His Asp Gln Asn Ile Ala Tyr Phe Ser Asn Pro Pro Ile Pro Tyr 35 40 45Ser Thr Pro Leu Gln Pro Pro Ser Phe Ser Gly Phe Gly His Ile Leu 50 55 60Asn Asn His Pro His His Thr Ser Tyr Gln Gly Tyr Phe Asn Ser Asn65 70 75 80Pro Ser His Gln Val Asn Ser His His Pro Arg Leu Pro Thr Glu Thr 85 90 95Asn Pro Val Gln Gln Leu Ser Asp Val Arg His Val Lys Asn Ala Asn 100 105 110Pro Arg Leu Ile Arg Pro Ser Pro Pro Lys Glu Asp Thr Leu Pro Pro 115 120 125Pro Pro Pro Gln Arg Met Cys Val Pro Pro Ala Arg Asn Thr Thr Gln 130 135 140His Glu Asp Ser Lys Pro Met His Lys Pro Glu Val Val Phe Gly Thr145 150 155 160Glu Val Asp Thr Leu Met Lys Ala Ile Gln Ala Lys Pro Gln Pro Pro 165 170 175Ser Pro Gln Ala Glu His Gln Leu Pro Pro Leu Gln Gln Lys Phe Asn 180 185 190Ser Gly Val Thr Asn Trp Ile His Pro Ala Tyr Ala Asn Gln Met Gly 195 200 205Gly Asn Gln Ser Ile Phe Pro Asn Pro Pro Gln Asp Arg Ile Pro Pro 210 215 220Ala Asn Gln Lys Pro Lys Arg Lys Tyr Asp Cys Thr Leu Pro His Cys225 230 235 240Arg Lys Ser Phe Phe Gln Lys Thr His Leu Asp Ile His Met Arg Ala 245 250 255His Thr Gly Asp Lys Pro Phe Thr Cys Lys Glu Pro Ser Cys Gly Gln 260 265 270Arg Phe Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr 275 280 285Gly Glu Lys Pro Tyr Ser Cys Glu Ile Cys His Lys Lys Phe Ala Gln 290 295 300Arg Gly Asn Val Arg Ala His Lys Ile Thr His Glu Gln Ala Lys Pro305 310 315 320Phe Thr Cys Arg Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly 325 330 335Asn Leu Lys Ser His Gln Asn Lys Phe His Ala Gln Thr Leu Arg Asn 340 345 350Leu Thr Leu Arg Phe Ala Ser Ile Ala Asp Ile Glu Arg Met Ser Pro 355 360 365Gln Asp Lys Glu Leu Trp Ser Tyr Phe Ser Asn Leu Tyr Arg Asn Ser 370 375 380Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Val Ser Thr Ala385 390 395 400Lys Arg Ser Met Ser Ala Tyr Asp Gly Ser Pro Ser Glu Ser Glu Asp 405 410 415Asp Gly Lys Asp Arg Asn Arg Thr Tyr Asp Arg Ala Ser Ala Val Met 420 425 430Thr Ser Asn Asn Asp Glu Pro Asp Tyr Arg Glu Gln Leu Tyr His Asn 435 440 445Arg Asn Gly Gly His His 45056398PRTArtificial Sequencesynthesized 56Met Ala Glu Asp Pro Glu Arg Pro Arg Pro Phe Leu Cys Asp Trp Gln1 5 10 15Gly Cys Gly Lys Arg Phe Asn Arg Lys Ser Asp Leu Gln Arg His His 20 25 30Arg Ile His Thr Asn Glu Arg Pro Tyr Gly Cys Asn Trp Gln Asp Cys 35 40 45Gly Lys Arg Phe Ile Gln Arg Ser Ala Leu Thr Val His Leu Arg Thr 50 55 60His Thr Gly Glu Lys Pro His Gln Cys Glu Val Pro Glu Cys Arg Lys65 70 75 80Pro Phe Ala Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Arg 85 90 95Gly Glu Lys Pro Tyr Arg Cys Gln Asp Val Gly Cys Asn Lys Ala Phe 100 105 110Cys Arg Lys Thr Thr Arg Asp Lys His His Thr Asn Ser His Arg Gly 115 120 125Gly Ile Asn Arg Ser Met Thr Pro Arg Gln Gln Leu His Pro Ser Phe 130 135 140Gly Ser Gly Phe Asp Gln Phe His Met Ser Ala Pro Pro Glu Leu Thr145 150 155 160Ala Ser Thr Asp Ser Ser Pro Ala Asp Ser Thr Ala Tyr Ser Pro Ala 165 170 175Ala Leu Glu Gly Asp Trp Ser Asn Gln Asn Phe Asn Asn Tyr Thr His 180 185 190Leu Pro Asn Leu Gln Glu Ala Ser Ile Ala Leu Gln Asn Gln Ile Arg 195 200 205Ser Gln Gln Ile Pro Gln Leu Met Ser Tyr Met Pro Ser Arg Val Leu 210 215 220Pro Ser Tyr Ser Ala Pro Pro Pro Asn Met Ile Thr Pro Gln Met Pro225 230 235 240Gln Gln Gly Ser Phe Ser Ser Tyr Ser Pro Ser Pro Val Glu Ser Ala 245 250 255Gln Gln Gln Pro Trp Ala Thr Gly Phe Gln Asn Asn Gln Arg Gln Tyr 260 265 270Pro Arg Val Leu Thr Ser Asn Asp Thr Ala Pro Arg Met Phe Ser Pro 275 280 285Tyr Pro Ala Pro Pro Asn Met Leu Pro Gly Gln Asn Asp Phe Asn Ser 290 295 300Gln Tyr Pro Pro Pro Gln Gln Gln Gln Ser Trp Gly Met Pro Gln Asn305 310 315 320Gln Gly Gln Gln Asp Gln Arg Gln Tyr Ser Leu Pro Ser Pro Ser Gln 325 330 335Pro Leu Thr Pro Val Pro Val Ser Ala Gly Thr Gly Thr Met Gln Pro 340 345 350Leu Gln Pro Met Pro Gly His Ile Tyr Gly Ala Arg Leu Val Gly Asp 355 360 365Asp Leu Asn Asp His Phe Phe Lys Val Glu Thr Thr Ala Asp Asp Asn 370 375 380Asn Pro Gly Met Thr Leu Pro Asp Ala Arg Phe Ala Gly Leu385 390 39557448PRTArtificial Sequencesynthesized 57Met Gly Ile Gly Asn Val Leu Asn Ile Lys Ala Glu Ser Gly Gly Gln1 5 10 15Gln Ala Ser Gln Gln Gly Ala Thr Ser Glu Leu Gln Gln Gln Arg Pro 20 25 30Pro Gln Gln Leu Gln Gln Leu Gln Val Asp Arg Gln Gly Ser Pro Gln 35 40 45Gly Ser Glu Gln Pro Arg Tyr Ser Gly Pro Met Ser Ala Ser Tyr Pro 50 55 60Ser Pro Thr Ala Met Ala Pro Ala Pro Leu Pro Pro Val Pro Asn Ala65 70 75 80Asn Met Ala Pro Ala Pro Met Val Pro His Glu Met Gln Gln Asn Ile 85 90 95Gly Ile Val His Pro Ala Tyr Gln Gln Thr Gln Gln Pro Pro Gln Ala 100 105 110Pro Ala His Gln Pro Pro Ala Lys Gln Phe Pro Cys Ser Thr Cys Gly 115 120 125Lys Pro Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His 130 135 140Ser Gly Ile Arg Pro His Val Cys Asp Tyr Pro Gly Cys Gly Lys Gln145 150 155 160Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly 165 170 175Glu Lys Pro His Arg Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser 180 185 190Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr 195 200 205Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr 210 215 220Leu Thr Arg His Gln Asn His His Val Gly Thr Val Glu Asp Ser Ala225 230 235 240Arg Ala Arg Ala Glu Ala Leu Ala Gln Gly Ala Asn Ala Ala Ala Ala 245 250 255Ala Ala Ala Ala Ala Ala Ala Ala Arg Asn Lys Ser Gln Ser Ala Ser 260 265 270Glu Gln Ala Ser Asn His Glu Ser Pro Ile Thr Thr Pro Ser Pro Gly 275 280 285Gln Arg Pro Ile Ser Met Ser Pro Gly Ala Glu Leu Ala Gly Met Asn 290 295 300Asn Met Gln Tyr Leu Ser Asn Ser Ile Pro Ala His Leu Arg Gly Asp305 310 315 320Val His Val Gly Ser Pro Ser Pro Thr Ala Ser Thr Gly Tyr Asn Asn 325 330 335Gly Met Arg Pro Thr Ser His Pro Thr Gly Tyr Ala Pro Pro Gln Thr 340 345 350Leu Glu Pro Ser Ile Glu Gln Pro Gln Gln Gly Pro Gly Ser Ala Val 355 360 365Gly Ser Pro His Ile Gly Ser Val Gly Trp Ala Ser Pro Gly Pro Val 370 375 380Gly Ser Pro Thr Gln Ser Pro Asn Gly Asn Gly Tyr Val Tyr Pro Asp385 390 395 400Pro Glu Ser Tyr Pro Ser Gly Thr Pro Ile Ala Gln Met Phe Tyr Asn 405 410 415Asn Ala Val Ala Thr Arg Arg Pro Glu Ser Ala Glu Pro Ala Asn Pro 420 425 430Ser Phe Asp Ala Lys Gly Arg Gln Gly Glu Leu Trp Thr Asn Ala Gln 435 440 44558416PRTArtificial Sequencesynthesized 58Asn Gly Leu Val Ala Ala Pro Thr Ala Pro Ser Thr Thr Thr Thr Ala1 5 10 15Val Gly Ser Ala Ala Ser Gly Ala Gly Met Gly Ile His Asn Asn Pro 20 25 30Ala Val Met Pro Pro Arg Thr Val Pro Met Val Asn Ser Phe Gly Glu 35 40 45Ala Ala Pro Ala Gly Gly Asp His Trp Pro Lys Thr Pro Phe Met Gly 50 55 60Ser Ser Asp Ala Ser Val Thr Thr Ser Ser Ile Ser Ser Thr Ser Ser65 70 75 80Ser Ser His Arg Arg Asp Arg Leu Gly Arg Asp Arg Glu Arg Asp His 85 90 95His Ser Ser Arg Asp His His His His Ala Arg Glu Arg Asp His Ser 100 105 110Ser Ser Gly Lys Arg His His His His Ser Ser Arg Arg His Ser His 115 120 125His Arg Ser Ser Arg Arg Gln Ser Asp Asp Ser Asp Ser Ala Gly Ser 130 135 140Asp Glu Asp Gly Ser Tyr Ala Arg Gly Gly Leu Arg Arg Ala Arg Asn145 150 155 160His Ser Ser Asp Ser Gly Ser Ser Ser Ala Glu Asp Ser Asp Asp Thr 165 170 175Asp Ala Glu Asp Asp Ser Arg Arg His Thr Thr Ala Val Thr Arg Ala 180 185 190Asn Ala Arg His Ala Leu Ala Glu Gly Phe Leu Leu Asp Asp Val Thr 195 200 205Cys Gly Gln Cys Gly Lys Ile Phe Arg Arg Pro Asp Arg Leu Ser Ala 210 215 220His Val Arg Thr His Ala Thr Met Arg Pro Phe Val Cys Thr Met Ala225 230 235 240Asp Cys Ser Lys Thr Phe Arg Glu Lys Ala Ala Leu Lys Lys His Met 245 250 255Ile Ser His Gly Asp Ile Arg Pro Tyr Thr Cys Glu Arg Cys Gly Ala 260 265 270Gly Phe Lys Phe Asn His His Leu Lys Arg His Asp Thr Arg Cys Leu 275 280 285His Arg Leu Asn Arg Ile Cys Gly Ser Lys Ala Pro Pro Thr Val Gln 290 295 300Gln Arg Ala Leu Glu Met Leu Ser Gln Ala Gly Phe Arg Ala Val Ala305 310 315 320Gly Thr Asp Ser Val Asn Leu Val Met Phe Asn Pro Glu Ser Met Ala 325 330 335Thr Thr Lys Pro Glu Glu Ala Met Ser Gly Thr Ala Pro Ser Val Ser 340 345 350Ser Pro Glu His Glu His Asn Met Ser Ala Ser Asp Asp Ala Ser Glu 355 360 365Ala Ser Ser Asn Gln His Ser Ala Ser Ser Leu Ser Ala Thr Phe Asp 370 375 380Leu Pro Thr Ser Trp Lys Pro Glu Asp Ser Gly Ala Ala Asp Ala His385 390 395 400Ser Arg Tyr Ser Leu Val Pro Val Ala Pro Ser Ala Thr Pro Val Ala 405 410 41559403PRTArtificial Sequencesynthesized 59Met Glu Arg Ser Val Ser Pro His Met Ser Glu His Ser Ser Tyr Ser1 5 10 15Thr Pro His Ser Ile Ala Arg Ser Tyr Thr Ser Pro Ser Ala Met Gln 20 25 30Ala Pro Met His Met Pro Ser Ser Met Thr Gly Gln Met Ala Met Pro 35 40 45Thr Phe Ser Asp Met Pro Gly Ala Met Gly Thr Val His Asn Met Thr 50 55 60Met His His Met Pro Gln Gln His Gln Pro Pro Pro Gln Pro Ser Lys65 70 75 80Ser Phe Leu Cys Gly Thr Cys Ser Lys Ser Phe Ala Arg Arg Ser Asp 85 90 95Leu Ala Arg His Gly Leu Arg Pro His Val Cys Asp His Leu Gly Cys 100 105 110Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Lys Arg Val 115 120 125His Thr Gly Glu Lys Pro His His Cys Glu Thr Cys Ala Lys Arg Phe 130 135 140Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Thr His Thr Gly Asn145 150 155 160Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg 165 170 175Arg Thr Thr Leu Thr Arg His Gln Asn His His Ser Gly Thr Ile Glu 180 185 190Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala Ala Ser Lys Ala Gln 195 200 205Lys Gly Gly Thr Arg Thr Arg Ala Asp Gly Asp His Leu Ser Ser His 210 215 220Gly Ser Pro Met Thr Thr Pro Ser Pro Ser His Arg Thr Met Ser Met225 230 235 240Ser Pro Ser Leu Asp Met Gly Ala Ala Asn Asn Met Asn Arg His Pro 245 250 255Gly Asp Phe Gln Tyr Leu Gln Gln Thr Gly Ser Leu Pro Pro His Leu 260 265 270Arg Gly Val Gly Ser Pro Asn Ser Thr Ser Ser Asn Gly Tyr Asn Asn 275 280 285Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Ser Asn Ser 290 295 300Asn Asn Gly Met Arg Pro Thr Ser His Pro Asn Thr Tyr Gly Pro Pro305 310 315 320Pro Ile Leu Glu Pro Asn Leu Glu Gln His Gln Ser Gly Pro Gly Ser 325 330 335Met Gly Gly Ser Pro His Met Thr Ser Leu Gly Trp Gln Ser Pro Ser 340 345 350His Val Pro Ser Pro Ser Gln Asn Gly Ala Ser Tyr Val Tyr Pro Glu 355 360 365Pro Asp Thr Tyr Ser Gln Asn Ala Ala Met Asn Gln Met Tyr Tyr Gly 370 375 380Ala Pro Pro Gln Met Arg Arg Gln Gln Ser Thr Glu Pro Gly Leu Val385 390 395 400His Met Ala60453PRTArtificial Sequencesynthesized 60Met Gln Gln Gln His Phe Gly Ala Pro Pro Ser Tyr Leu Asn Gly Gly1 5 10 15His Ile Lys Ser Glu Asn Gly Ser Glu Arg Gly Val Ser Pro His Pro 20 25 30Ser Asp Ser Ser Arg Tyr Ser Ser Gln Gln Pro Gln Gln Gln Leu Pro 35 40 45Ser Tyr Pro Ser Ile Pro Gln Gln His Met Asn Gly Leu Arg Tyr Pro 50 55 60Ser Pro Ser Gln Met Gln Ala Pro Met Pro Met Leu Asn Asn Ser Asn65 70 75 80Tyr Ile Pro Thr

Pro Pro Glu His Thr Tyr Ala Gln Gln Gln Gln Leu 85 90 95Pro Asp Ala Gln Val Gly His Gln His Asn Gly Gly Arg Pro Ala Ser 100 105 110Asp Thr Gly Pro Pro Lys Ala Phe Ala Cys Ser Thr Cys Gly Lys Gly 115 120 125Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly 130 135 140Ile Arg Pro His Val Cys Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile145 150 155 160Gln Arg Ser Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys 165 170 175Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 180 185 190Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 195 200 205Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr 210 215 220Arg His Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala225 230 235 240Thr Ala Ala Ala Leu Ala Ser Arg Ala Ser Gln Ser Ser Arg Thr Gly 245 250 255Arg Ser Asp Gly Gly Asp Tyr Ser Glu Thr Ala Ser Pro Leu Gly Thr 260 265 270Pro Ser Pro Asn Asp Arg Thr Leu Ser Leu Ser Pro Ala Asn Gly Met 275 280 285Pro Ala Gly Gly Met Pro Gly Leu His Arg Gln Gly Ser Asp Tyr Ala 290 295 300Tyr Met Gly Gly Met Asn Val Pro Pro His Met Arg His Glu Met Pro305 310 315 320Gln Pro Ser Pro Arg Ala Ser Pro Ala Leu Thr Ala Gln Ser Tyr Ala 325 330 335Ser Asn Val Ser Gly Ser Arg Pro Ala Ile Thr Ser His Pro Ser Ala 340 345 350Tyr Gly Pro Pro Pro Ile Leu Glu Pro Pro Ala Ser Ala Asn His Gly 355 360 365Gln Ser Gly Gly Thr Ser Ser Ala Asn Gly Ser Pro His Met Ser Thr 370 375 380Met Gly Trp Gln Ser Pro Gly Gln Gln Ala Leu Pro Ser Pro Gly Ala385 390 395 400Asn Asp Asn Gly Tyr Val Tyr Pro Glu Pro Gln Tyr Gln Ala Gln Asn 405 410 415Gly Met Tyr Tyr Gln His Asn Asn Ile Arg Arg Pro Asn Ser Thr Glu 420 425 430Pro Asp His Tyr Asn Pro Asn Gln Gln Arg Met Gly Asn Glu Met Trp 435 440 445Ala Pro Ala Val Gln 45061381PRTArtificial Sequencesynthesized 61Met Glu Leu Phe Gln Ile Met Ala Glu Asp Pro Glu Arg Pro Arg Pro1 5 10 15Phe Leu Cys Asp Trp Gln Gly Cys Gly Lys Arg Phe Asn Arg Lys Ser 20 25 30Asp Leu Gln Arg His His Arg Ile His Thr Asn Glu Arg Pro Tyr Gly 35 40 45Cys Asn Trp Gln Asp Cys Gly Lys Arg Phe Ile Gln Arg Ser Ala Leu 50 55 60Thr Val His Leu Arg Thr His Thr Gly Glu Lys Pro His Gln Cys Glu65 70 75 80Val Pro Glu Cys Arg Lys Pro Phe Ala Asp Ser Ser Ser Leu Ala Arg 85 90 95His Arg Arg Ile His Arg Gly Glu Lys Pro Tyr Arg Cys Gln Asp Val 100 105 110Gly Cys Asn Lys Ala Lys Thr Thr Arg Asp Lys His His Ser Asn Ser 115 120 125His Arg Gly Gly Ile Asn Arg Ser Met Thr Pro Arg Gln Gln Leu His 130 135 140Pro Thr Phe Ser Ser Glu Phe Asp Gln Phe His Met Ser Ala Pro Pro145 150 155 160Asp Leu Thr Ala Ser Thr Glu Ser Ser Pro Ala Asp Ser Thr Ala Tyr 165 170 175Ser Pro Ala Ala Leu Glu Gly Asp Trp Ser Asn Gln Ser Phe Asn Asn 180 185 190Tyr Thr His Leu Pro Asn Leu Gln Glu Ala Ser Leu Ala Leu Gln Asn 195 200 205Gln Ile Arg Ser Gln Gln Ile Pro Gln Leu Met Pro Tyr Met Pro Ser 210 215 220Arg Val Met Pro Ser Tyr Ser Ala Pro Pro Ser Asn Met Met Thr Gln225 230 235 240Gln Met Pro Gln Gln Gly Asn Phe Ser Ser Tyr Ser Pro Ser Pro Val 245 250 255Glu Ser Thr Gln Gln Gln Pro Trp Gly Thr Gly Cys Ser Arg Pro Ile 260 265 270Arg Leu Pro Pro Asn Met Met Pro Gly Gln Asn Asp Phe Asn Ser Gln 275 280 285Tyr Pro Pro Pro Gln Gln Gln Gln Ser Trp Gly Met Pro Gln Asn Gln 290 295 300Gly Gln Gln Glu Gln Arg Gln Tyr Ser Leu Pro Ala Pro Ser Gln Pro305 310 315 320Met Thr Pro Val Pro Val Ser Ala Gly Thr Gly Asn Ile Gln Pro Met 325 330 335Gln Pro Met Pro Gly His Ile Tyr Gly Ala Arg Leu Val Gly Asp Asp 340 345 350Leu Ser Asp His Phe Phe Lys Val Glu Thr Ser Ala Asp Asp Asn Asn 355 360 365Pro Gly Met Thr Leu Pro Asp Ala Arg Phe Ala Gly Leu 370 375 38062411PRTArtificial Sequencesynthesized 62Met Asp Val Met Glu Leu Val Glu Asn Glu Gln Asn Ala Arg Pro Phe1 5 10 15Gln Cys Asp Trp Lys Thr Cys Thr Lys Ser Phe Asn Arg Lys Ser Asp 20 25 30Leu Gln Arg His Tyr Arg Ile His Thr Asn Glu Arg Pro Tyr Ser Cys 35 40 45Val Thr Pro Gly Cys Gly Lys Ser Phe Ile Gln Arg Ser Ala Leu Thr 50 55 60Val His Ile Arg Thr His Thr Gly Glu Lys Pro His Gln Cys Gln His65 70 75 80Ile Gly Cys Gly Lys Arg Phe Ser Asp Ser Ser Ser Leu Ala Arg His 85 90 95Arg Arg Ile His Thr Gly Lys Arg Pro Tyr Lys Cys Ala His Asp Gly 100 105 110Cys Leu Lys Ser Phe Cys Arg Lys Thr Thr Met Val Lys His Gln Arg 115 120 125Arg Ser His Gln Arg Gly Ile His Ser Ser Glu Leu Asp Asp Gly Glu 130 135 140Thr Ser Asp Ser Asp Ser Gly Glu Ser Pro Thr Thr Pro Gln His His145 150 155 160Ser Ser Gln Ile Gln Trp Pro Gln His Leu Thr Val Pro Gly Val Pro 165 170 175His Gly His Gln Met His Arg Ala His Ser Phe Ala Asp Phe Gly Gln 180 185 190His Gln His Ile Asp Gly Tyr Pro Met Pro Gln Ala Tyr Ala His Arg 195 200 205His Ser Leu Ser Gly Gly Pro Gln Ala Tyr Gly Pro Ile Pro Asp Gln 210 215 220His His His Val Met Gln Arg Gln Pro Ser Leu Gln His Ala Ser Tyr225 230 235 240Tyr Val Pro Glu Gln Asn Asn Pro Gly Val Ala Thr Leu Asn Thr Asn 245 250 255Pro Ala Pro Ile Gln Thr Tyr His Ile Pro Arg His Ser Met Glu Arg 260 265 270His Pro Gln Glu Ile Leu Gln Ser Ser Pro Gly Ser Tyr Ser Ser His 275 280 285Ser Arg Ala Ser Pro Val Ser Gln Glu Pro Tyr Tyr Thr His Ala Gln 290 295 300His Ser Val His Val Pro Thr Tyr Ala Ile His Gly Gln Ser Pro Thr305 310 315 320Glu Ser Gln Pro Met Ile His Tyr Gln Gln His Val Pro Thr Pro Gln 325 330 335Ser Ile Pro Ser Pro Val Ala Gln Val Gln His Gln Leu Gln His Gln 340 345 350Tyr Pro Gln Pro Pro Glu His Gly Gln Trp Tyr Glu Ser Thr Pro Tyr 355 360 365Gln Gln Pro Glu Val Ile Ser Asn Val Pro Met Tyr Pro Gln Val Thr 370 375 380Val Phe Ser Asp Pro Trp His Lys Leu Glu Thr Phe Asp Asp Pro Ser385 390 395 400Leu Gln Met Pro Ser Ala Arg Ile Glu Asn Leu 405 41063367PRTArtificial Sequencesynthesized 63Met Asp Ile Val Asn Leu Val Asn Asn Ala Asp Thr Arg Lys Ser Ser1 5 10 15Lys Asn Ala Ser Thr Gln Pro Arg Pro Phe Ala Cys Thr Tyr Gly Asn 20 25 30Cys Thr Lys Ala Phe Ala Arg Arg Ser Asp Leu Gln Arg His Leu Arg 35 40 45Ile His Leu Asn Glu Arg Pro Phe Ala Cys Pro Ile Asp Gly Cys Ser 50 55 60Lys Thr Phe Ile Gln Arg Ser Ala Leu Thr Val His Ile Arg Val His65 70 75 80Thr Gly Glu Arg Pro His Thr Cys Glu Gln Cys Gly Lys Ala Phe Ser 85 90 95Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Lys Arg 100 105 110Pro Tyr Lys Cys Pro Val Glu Gly Cys Asn Lys Thr Phe Cys Arg Lys 115 120 125Thr Thr Leu Thr Lys His Thr Lys Arg Asn His Gln Ser Gln Ser Ser 130 135 140Leu Ser Asn Ser Pro Ser Pro Ser Pro Ser Pro Glu Ala Gln Gln Ser145 150 155 160Asn Val Pro Ala Leu Thr Ile Pro Gln Pro Leu Thr Gln Gln Leu Ser 165 170 175Gln Ser Pro Leu Gln Cys Leu Pro Ile Thr Gln Pro Ser Leu Tyr Ala 180 185 190Leu Ser Gln Glu Glu Lys Pro Gln Phe Met Asp Asn Ser Gln Phe Arg 195 200 205Leu Gln Ser Pro Ile Cys Met Ser Ser Tyr Gln Ser Gln Glu Ser Pro 210 215 220Ser Asn Ser Thr Val Phe Ser Ser Pro Thr Thr Pro Thr Tyr Ala Thr225 230 235 240Glu Ala Gln Phe Leu Tyr Gln His Pro Pro Pro Pro Gln Gly Ala Phe 245 250 255Ser Tyr Tyr Glu Ser Thr Ser Pro Phe Leu Tyr Val Asp Thr Ser Asn 260 265 270Gln Lys Ser Gln Met Gly Leu Asn Asn Gln Ser Gln Leu Leu Thr Pro 275 280 285Pro Gln Ser Ala Asp Pro Asn Asn Phe Gly Pro Phe Ala Tyr Val Pro 290 295 300Pro Pro Leu Ala Val Thr Asp Asp Tyr Asn Thr Tyr Pro Phe Val Pro305 310 315 320Pro Ser Pro Pro Leu Thr Gly Asn Cys Glu Thr Ser Tyr Ser Asn Gln 325 330 335Ser Leu Ile Asp Glu Ser His Tyr His His Glu Thr Tyr Pro His Pro 340 345 350Asn Val Leu Thr Gly Leu Gly Leu Asp Leu Val Gln Asp Gly Glu 355 360 36564320PRTArtificial Sequencesynthesized 64Met Ala Pro Gly Gly Ser Arg Gly Phe Asn Cys Ser Trp Glu Asn Cys1 5 10 15Gly Lys Ser Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile 20 25 30His Thr Asn Glu Arg Pro Tyr His Cys Thr Val Pro Ser Cys Asn Lys 35 40 45Ser Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr 50 55 60Gly Glu Lys Pro His Val Cys Asp His Glu Asp Cys Arg Lys Ala Phe65 70 75 80Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Arg 85 90 95Arg Pro Tyr Ile Cys Ser Glu Pro Ala Cys Asp Arg Ser Phe Cys Arg 100 105 110Lys Thr Thr Leu Thr Lys His Gln Ser Arg Thr His Gln Pro Gly Val 115 120 125Asn Thr Arg Pro Ser Ser Glu Glu Ala Pro Thr Pro Glu Ser Met Thr 130 135 140Tyr Gln Thr Pro Val Met Thr Thr Met Pro Pro Asn Ser Asn Gln Tyr145 150 155 160Ile Leu Ala Gln Gln Pro Tyr Tyr His Asn Gly Pro Thr Pro Thr Thr 165 170 175Ala Asp Phe Tyr Gln Thr Pro Gln Pro Ala Ile His Phe Pro Gln Pro 180 185 190Gln Ala Met Val Pro Gln Pro Ile Pro Thr Ala Gly Leu Pro Thr Pro 195 200 205Pro Phe Glu Pro Gln His Tyr Ala Gln Ile Met Gln Gln Gln Gln Pro 210 215 220Arg Tyr Asp Pro Thr Tyr Ile Gln Pro Gln Tyr Gln Ser Pro Thr Pro225 230 235 240Pro Phe Val Ala Gln Pro Gln His His Met Thr Ala Asp Gly Arg Pro 245 250 255Ile Val Ala Thr Tyr His Pro Asp Gln Phe Lys Pro Pro Ala Arg Ile 260 265 270Leu Ser Ser Gln Glu Ala Met Leu Ile Arg Phe Ser Pro Ala Leu Ser 275 280 285Thr Leu Ala Gly Gly Ala Thr Pro Asp Pro Glu His Arg Thr Pro Asn 290 295 300Phe Gly Ser Gly Val Met Arg Thr Ser His Ser Trp Pro Phe Pro Pro305 310 315 32065295PRTArtificial Sequencesynthesized 65Gln Gln Gln Gln Gln Gln Gln Arg Gln Gln His Arg Gln Gln Thr Pro1 5 10 15Gln Gln His Glu Arg Tyr Glu Lys Gln Gln His Pro Gln Asp Tyr Asn 20 25 30Ser Asn Ser Asn Asn Ser Asn Asn Asn His Asn Asn Asn Ile Ser Ser 35 40 45Ser Asn Thr Asn Asn Thr Lys Glu Lys Lys Leu Ile Asn Ser Asn Ser 50 55 60Ser Leu Lys Arg Asp Asp Gly Arg Pro Leu Val Gly Ala Thr Lys Val65 70 75 80Asp Gln Leu Met Leu Ile Ile Gln Ala Arg Gln Lys Gly Val Cys Gly 85 90 95Asn Ile Glu Gln Ser Glu Asp Gly Asn Ile Asp Glu Glu Asn Ile Leu 100 105 110Pro Asn Pro Ile Glu Leu Val Gly Gly Val Glu Lys Thr Ser Leu Lys 115 120 125Gly Asp Lys Ser His Gln Cys Lys Tyr Cys Gln Lys Lys Phe Thr Gln 130 135 140Ser Thr His Leu Asp Val His Leu Arg Ser His Met Gly Val Lys Pro145 150 155 160Tyr Lys Cys Glu Phe Cys Asp Lys Arg Phe Thr Gln Gly Gly Asn Leu 165 170 175Arg Thr His Met Arg Leu His Thr Gly Glu Lys Pro Phe Lys Cys Asn 180 185 190Ile Cys Asp Lys Gln Phe Ser Arg Lys Gly Asn Leu Gln Ala His His 195 200 205Leu Thr His Asp Asn Ser Lys Pro Phe Ile Cys Lys Phe Asp Gly Cys 210 215 220Asn Lys Gly Phe Thr Gln Leu Gly Asn Leu Lys Ala His Gln Asn Arg225 230 235 240Phe His Leu Asp Thr Ile Asn Glu Leu Phe Asn Lys Leu Ala Gln Leu 245 250 255Gly Glu Gly Ile Gly Ser Tyr Asp Ser Leu Pro Lys Ser Glu Lys Asp 260 265 270Leu Leu Asp Tyr Phe Ser Ser Leu Tyr Lys Asn Leu Asn Lys Gly Ile 275 280 285Lys Gly Arg Gly Lys Ala Arg 290 29566494PRTArtificial Sequencesynthesized 66Met Ser Gln Ser Pro Ser Ala Ser Gly Ala Met Gly Ile Gly Ser Val1 5 10 15Leu Asn Asn Lys Gly Ala Ala Ala Ala Gln Ala Leu Gln Gln Ala Gly 20 25 30Ala Met Pro Val Asp Gln Gln Val Gln Gln Gln Leu Gln Gln Gln Val 35 40 45Gln Gln Val Gln Gln Val Gln Gln Gln Val Gln Gln Gln Ala Gln Gln 50 55 60Val Gln Gln Ala Gln Gln Leu Gln Gln Ala Gln Gln Pro Leu Gln Gln65 70 75 80Val Gln Gln Gln Gln Gln His Gln Gln Gly Gln Thr Ile Pro Gln Gln 85 90 95Val Pro Met Asn Arg Pro Asn Ser Pro His Gly Ser Glu Asn Ser Gly 100 105 110Tyr Thr Tyr Pro Ser Pro Thr Ala Ile Gly Gly Ala Pro Leu Pro Pro 115 120 125Ala Asn Met Ala Pro Ala Pro Met Gly Ile Pro Met Gln Gln Thr Met 130 135 140Gln Gln Pro Met Pro Gln Ser Met Ile Pro Val Met His Pro Gly Phe145 150 155 160Lys Thr Glu Pro Thr Pro Ala Pro Gln Gln Pro Pro Pro Lys Ala Tyr 165 170 175Pro Cys Gln Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala 180 185 190Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys Asp Tyr 195 200 205Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His 210 215 220Gln Arg Val His Thr Gly Glu Lys Pro His Gln Cys Glu Arg Cys Gly225 230 235 240Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His 245 250 255Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Val Asp Cys Gln Lys Thr 260 265 270Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly 275 280 285Thr Val Glu Asp Ser Gln Arg Ala Arg Asn Glu Ala

Leu Ala Gln Gly 290 295 300Ser Asn Thr Ala Leu Ala Ala Ala Ala Ile Arg Asn Lys Arg Gly Asp305 310 315 320Ser Glu Gln Ala Ser Asn Gln Glu Ser Pro Ile Thr Thr Pro Ser Pro 325 330 335Ala Gln Arg Pro Met Ser Met Ser Pro Asn Glu Asp Leu Ala Asn Ile 340 345 350Asn Asn Met Gln Gln Tyr Leu Thr Asn Thr Ser Leu Pro Pro His Ile 355 360 365Arg Gly Asp Val His Gly Gly Ser Pro Val Ser Thr Ala Ser Ser Gly 370 375 380Tyr Asn Asn Gly Met Arg Pro Thr Ser His Pro Ser Gly Gly Tyr Ala385 390 395 400Pro Pro Pro Pro Leu Glu Pro Ser Leu Asp Gln Phe Gln Gln Gly Pro 405 410 415Gly Ser Ala Ser Gly Ser Pro His Ile Gly Ser Val Gly Trp Ala Ser 420 425 430Pro Gly Pro Val Gly Ser Pro Thr Glu Ser His Gly Gln Gly Ala Ser 435 440 445Val Tyr Pro Asp Pro Glu Pro Ser Tyr Gln Asn Thr Ala Gln Met Gly 450 455 460Gln Ile Tyr Tyr Ala Ser Ala Ala Thr Gln Gly Arg Arg Pro Gly Ser465 470 475 480Thr Glu Pro Gly Gln Arg Pro Ser Glu Met Trp Thr Gly Gln 485 49067498PRTArtificial Sequencesynthesized 67Met Pro Arg Ala Leu Ile Pro Lys Pro Asp Gln Pro Arg Gly Ala His1 5 10 15Glu Cys Ala Val Cys Glu Lys Ala Phe Lys Asn Arg Ser Glu Leu Ala 20 25 30Arg His Gln Asn Ile His Arg Glu Asp Lys Pro Phe Val Cys Thr Glu 35 40 45Cys Gly Lys Lys Phe Ala Gln Asn Gly Gln Leu Thr Asn His Arg Asn 50 55 60Thr His Phe Gly Phe Arg Pro Ser Lys Cys Ala Phe Cys Pro Arg Asp65 70 75 80Phe Ala Glu Gly Gly Ser Thr Gly Arg His Glu Arg Glu Gln His Ser 85 90 95Asn Phe Ala Gly Phe Gln Cys Pro Val Ser Gly Cys Glu Phe Met His 100 105 110Lys Arg Lys Gly Asp Tyr Asn Val His Leu Ala Gly His Gly Val Ser 115 120 125Pro Ser Ser Val Asn Pro Trp His His Ala Tyr Thr Thr Asp Gly Ser 130 135 140Lys Ile Asp Pro Thr Arg Gly Leu Arg Glu Gln Leu Glu Trp Glu Pro145 150 155 160Phe Leu Lys Asp Gly Arg Asp Gly Ala Gly His Pro Asn Arg Ala Arg 165 170 175Ala Lys Arg Thr Ala Thr Ser Leu Gly Lys Glu Arg Gln Thr Ala Pro 180 185 190Ala Gln Ala Pro Arg Thr Arg Ser Ser Arg Lys Arg Arg Ala Asp Glu 195 200 205Thr Asp Glu Asp Asp Asp Glu Asp Asp Glu Tyr Lys Pro Asn Thr Arg 210 215 220Ala Arg Ala Ala Lys Arg Val Arg Gln Ser Pro Pro Glu Pro Glu Pro225 230 235 240Glu Val Lys Pro Ala His Ala Val Ser Glu Asp Ala Phe Asp His Leu 245 250 255Phe Thr Ile Ser Pro Thr Ser Asp His Gly Ser Asn Val Gly Leu Pro 260 265 270Ser Gly Ser Ser Ser Ser Leu Thr Ser Leu Ala Ala Thr Pro Asp Pro 275 280 285Gln Gln Gly Glu Leu Gln Tyr Ala Leu Asp Ala Tyr Gly Cys Ala Ser 290 295 300Pro Val Ala Gly Pro Ser Ala Ser Tyr Asn Pro His Asn Val Leu Gly305 310 315 320Leu Ala Leu Pro Asp Gln Ser Ser Ala Tyr Leu Gly Tyr Gln Ser Pro 325 330 335Leu Ser Gly His Gln Ala Leu Asp Gln Cys Gly Ala Thr Ser Asp Leu 340 345 350Gly Leu Leu Met Ala Gln Gln Ala Pro His Gly His Tyr Glu Phe Asp 355 360 365Met Ala Ala Phe Glu Ala Ser Leu Cys Asp Gly Thr Phe Phe Phe Asp 370 375 380Asn Asn Asp Leu Val His Ala Gln Pro Met Gln Phe Gln Ala Ser Tyr385 390 395 400Asp Ser Tyr Asn Ile Pro Pro Pro Asn Val Ser Ser Tyr Leu His Gly 405 410 415Gly Leu Tyr Gln Tyr Asp Asn Leu Ala Pro Ala Met Ser Ala Asp Leu 420 425 430Leu Ser Ala Ser Ser Pro Leu Thr Ser Ser Ser Gln Gly Thr Ser Arg 435 440 445Ser Pro Ser Pro Leu Gly Leu Gly Leu Gly Ser Asn Gly Phe Ser Val 450 455 460Pro Ser Ile Ser Ser Leu Gly Arg Ala Arg Ala Asn Ala Gln Leu Ile465 470 475 480Met Pro Gln Val Tyr Gln Asp Ile Ala Leu Leu His Gly Tyr Pro Thr 485 490 495Ser Met68501PRTArtificial Sequencesynthesized 68Met Glu Leu Asp Thr Ile Leu Asn Ala Arg Leu Thr Gln Tyr Ala Gly1 5 10 15His Gly His Pro His Pro Phe Gly Met Gln His Ala Met Gln His Glu 20 25 30Met Gln Gln Gln His Phe Gly Ala Pro Pro Tyr Met Ala Asn Gly Arg 35 40 45Ile Lys Ser Glu Asn Gly Ser Glu Arg Gly Val Ser Pro His Pro Ser 50 55 60Asp Ser Ser Arg Tyr Ser Ser Gln Gln Pro Gln Gln Pro Leu Pro Ser65 70 75 80Tyr Pro Ala Met Pro Pro Gln His Met Asn Gly Met Arg Tyr Pro Ser 85 90 95Pro Ser Gln Met Gln Ala Pro Met Pro Met Leu Asn Asn Asn Asn Tyr 100 105 110Ile Pro Gln Pro Pro Asp His Ala Tyr Gly Gln Gln Gln Gln Gln Gln 115 120 125Val Pro Asp Gln Gln Gln His Gln Gly Gly Arg Pro Ala Ser Asp Thr 130 135 140Gly Pro Pro Lys Ala Phe Ala Cys Ser Thr Cys Gly Lys Gly Phe Ala145 150 155 160Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg 165 170 175Pro His Val Cys Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg 180 185 190Ser Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His 195 200 205Met Cys Glu Arg Ser Trp Lys Gly Thr Phe Ala His Ser Thr Ala Lys 210 215 220Gly Leu Ala Asn Ile Thr Gln Pro Phe Ser Asp Ser Ser Ser Leu Ala225 230 235 240Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr 245 250 255Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 260 265 270Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala 275 280 285Ala Ala Leu Ala Ser Arg Ala Ala Ala Pro Ser Arg Thr Gly Arg Ser 290 295 300Asp Gly Gly Asp Tyr Ser Glu Asn Ala Ser Pro Leu Asn Thr Pro Ser305 310 315 320Pro Gly Asp Arg Thr Leu Ser Met Ser Pro Ala Asn Gly Met Pro Ala 325 330 335Gly Val Val Pro Gly Met His Arg Gln Ala Thr Asp Tyr Ala Tyr Met 340 345 350Gly Gly Met Asn Val Pro Pro His Met Arg Ser Glu Met Pro Gln Pro 355 360 365Ser Pro Arg Ala Ser Pro Ala Leu Thr Thr Gln Ser Tyr Ser Ser Val 370 375 380Gly Ser Ser Arg Pro Pro His His Leu Pro Pro His Arg Ile Trp Thr385 390 395 400Ser Pro His Pro Gly Ser Leu Pro Arg Leu Pro Asn His Asn Gln Phe 405 410 415Arg His His Ser Ala Pro Thr Ala Ala Pro His Met Phe Cys His Gly 420 425 430Ala Gly Gln Ser Pro Gly Gln Gln Ala Leu Pro Ser Pro Gly Gln Ala 435 440 445Asp Asn Gly Tyr Val Tyr Pro Glu Pro Gln Tyr Gly Asn Thr Gln Asn 450 455 460Ser Met Tyr Tyr Gln Asn His Asn Ile Arg Arg Pro Asn Ser Thr Glu465 470 475 480Pro Asp His Tyr Asn Ala Asn Pro Gln Arg Met Gly Asn Asp Leu Trp 485 490 495Ala Pro Ala Val Gln 50069428PRTArtificial Sequencesynthesized 69Met Ala Asp Val Leu Pro Ala Lys Ala Pro Ser Gln Leu Leu Gln Arg1 5 10 15Arg Leu Ser Gln Ala His Phe Asn Ala Met Gln Val Gln Gly Met Met 20 25 30Ala Gln Phe Asn Met Ala Phe Arg Pro Asp Ser Ala Ala Thr Ile Pro 35 40 45Leu Gln Met Leu Gln Ala Gln Glu Gln Gln Thr Leu Ala Met His Ala 50 55 60Ala Ser Val Ala Pro Ser Glu Leu Leu Asn Thr His Pro Ala Gln Thr65 70 75 80Met Asn Asn Ser Met Tyr Met Asp His Ser Ala Phe Gln Asn Ser Tyr 85 90 95Ser Ile Pro Val Gly Met Asn Asn Ala Thr Phe Gly Ser Leu Ala Trp 100 105 110Pro Ala Ser Ile Val Thr Asn Pro Asn Thr Met Ala Val Leu Pro Leu 115 120 125Val Arg Asn Glu Ser Tyr Ser Ser Val Glu Gly Ser Glu Pro Ser Ile 130 135 140Lys Thr Glu Asp Arg Ser Pro Ile His Pro Ser Gln Val Tyr Phe Asp145 150 155 160Ala Thr Ala Tyr Ala Ser Ser Pro Glu Ser Gln Thr Ala Thr Asp Ser 165 170 175Ser Glu Glu Thr Lys Pro Val Val Phe Ser Thr Glu Ile Asp Thr Leu 180 185 190Met Lys Ala Ile Gln Met Lys Thr Gln Pro Ala Glu Gln Arg Glu Ala 195 200 205Pro Lys Pro Lys Pro Ala Ala Ser Asn Asn Arg Ala Lys Lys Arg Tyr 210 215 220Thr Cys Asp Val Pro Asp Cys Gly Lys Ala Phe Tyr Gln Lys Thr His225 230 235 240Leu Glu Ile His Thr Arg Ala His Thr Gly Ile Lys Pro Phe Leu Cys 245 250 255Lys Glu Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu Lys 260 265 270Thr His Glu Arg Arg His Thr Gly Glu Arg Pro Tyr His Cys Asp Ile 275 280 285Cys Gly Lys Thr Phe Ala Gln His Gly Asn Val Arg Ala His Lys Ile 290 295 300Val His Thr Ala Ala Lys Pro Phe Thr Cys Lys Leu Asp Asn Cys Asn305 310 315 320Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe 325 330 335His Val Glu Thr Ile Arg Arg Leu Lys Ser Arg Phe Glu Asp Ile Lys 340 345 350Ala Gly Asp Val Val Glu Lys Trp Glu Lys Asp Met Trp Glu Tyr Phe 355 360 365Ala Gly Leu Tyr Lys Asn Cys Asn Lys Gly Ile Lys Gly Arg Gly Lys 370 375 380Asp Arg Arg Ile Ser Thr Thr Leu Leu Gly Ala Ala Gln Arg Arg Asp385 390 395 400Ser Met Val Ser Ala Glu Cys Ser Gly Gly Glu Gly Leu Ala Met Gln 405 410 415Ala Arg Arg Asp Ser Leu Thr Gly Thr Met His Gln 420 42570292PRTArtificial Sequencesynthesized 70Met Ala Pro Gly Gly Ser Arg Gly Phe Asn Cys Ser Trp Glu Arg Cys1 5 10 15Gly Lys Ser Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile 20 25 30His Thr Asn Glu Arg Pro Tyr His Cys Thr Val Pro Ser Cys Asn Lys 35 40 45Ser Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr 50 55 60Gly Glu Lys Pro His Val Cys Asp His Glu Asp Cys Arg Lys Ala Phe65 70 75 80Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Arg 85 90 95Arg Pro Tyr Ile Cys Ser Glu Pro Ala Cys Asp Arg Ser Phe Cys Arg 100 105 110Lys Thr Thr Leu Thr Lys His Gln Ser Arg Thr His Gln Pro Gly Gly 115 120 125Asn Thr Arg Pro Ser Ser Glu Glu Ala Pro Thr Pro Glu Ser Met Thr 130 135 140Tyr Gln Thr Pro Val Ile Thr Thr Met Ala Pro Asn Thr Thr Gln Tyr145 150 155 160Ile Ile Ala Gln Gln Pro Tyr Tyr His Asn Gly Pro Thr Pro Thr Thr 165 170 175Ala Asp Phe Tyr Gln Thr Pro Gln Pro Ala Ile His Phe Thr Gln Pro 180 185 190Gln Ala Met Val Pro Gln Gln Ile Pro Thr Ala Gly Leu Pro Thr Pro 195 200 205Pro Phe Glu Pro Gln His Tyr Ala Gln Ile Met Gln Gln Gln Gln Gln 210 215 220Pro Arg Tyr Asp Pro Thr Pro His Gln Thr Tyr Ile Gln Pro Gln Tyr225 230 235 240Gln Ser Pro Thr Pro Pro Phe Val Ala Gln His Gln His His Met Ala 245 250 255Ala Asp Val Arg Pro Leu Met Ala Thr Tyr His Pro Asp Gln Phe Lys 260 265 270Pro Pro Ala Arg Ile Leu Ser Ser Gln Glu Gly Thr Asp Trp Ser Phe 275 280 285Leu Gly Val Ser 29071416PRTArtificial Sequencesynthesized 71Met Leu Asn Lys Lys Gly Gln Leu Gln Gln Leu Asn Pro Gly Leu Leu1 5 10 15Asp His Gln His Gln Ala Phe Val Lys His Glu Pro Gly Met Glu Arg 20 25 30Ser Ala Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser Asn Pro His 35 40 45Ile Ala Arg Ala Tyr Pro Ser Pro Ala Ala Met Gln Ala Pro Met His 50 55 60Ile Pro Asn Pro Met Pro Ala Ala Met Gln Leu Pro Gly Phe Pro Glu65 70 75 80Met Pro Asn Met Gly Gly Met Pro Asn Met His Met Gln Gln Met Gln 85 90 95Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Ile Lys Ala Tyr Pro Cys 100 105 110Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His 115 120 125Glu Arg Ile His Ser Gly Val Arg Pro His Val Cys Asp Trp Pro Asn 130 135 140Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln Arg145 150 155 160Val His Thr Gly Glu Lys Pro His His Cys Glu Thr Cys Ala Lys Pro 165 170 175Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Thr His Ser Gly 180 185 190Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr 195 200 205Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Ser Gly Thr Ile 210 215 220Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala Ala Ser Lys Ser225 230 235 240Lys Gly Met Ser Gln Pro Arg Ser Glu Ser Asp Leu Met Ser Asn Asn 245 250 255Gly Ser Pro His Thr Thr Pro Ser Pro Gly Gln Arg Thr Met Ser Met 260 265 270Ser Pro Ser Val Asp Leu Ser Gly Thr Asn Ser Ile Pro Arg His Pro 275 280 285Gly Asp Phe Gln Tyr Leu Gln Gln Ser Gly Ser Leu Pro Met His Met 290 295 300Arg Val Gly Ser Pro Thr Ser Thr Ser Ser Gly Gly Tyr Asn Met Met305 310 315 320Arg Pro Thr Ser His Pro Thr Ser Tyr Gly Pro Pro Pro Thr Leu Glu 325 330 335Pro Asn Leu Glu His Ser Gln Gly Ala Pro Ser Ser Asn Gly Gly Ser 340 345 350Pro His Met Ala Asn Val Gly Trp Gln Ser Pro Ser His Val Pro Ser 355 360 365Pro Ser Gln Asn Asn Ala Ser Tyr Val Tyr Pro Asp Pro Ser Glu Ala 370 375 380Tyr Pro Thr Asn Pro Ala Met Asn Gln Met Tyr Tyr Gly Ala Ala Ala385 390 395 400His Met Arg Arg Pro Gln Ser Ala Glu Pro Gly Leu Val His Met Ala 405 410 41572446PRTArtificial Sequencesynthesized 72Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Gly Thr Ala Ala Val Ala1 5 10 15Ala Ala Glu Ala His Leu Gln Gln His Leu Val His Ala Thr His Met 20 25 30Lys Ser Lys Thr Pro Ser Glu Ile Ser Ser Glu His Gly Thr Pro Gln 35 40 45Asn Gly Asp Gln Ser Asn Ile Tyr His Pro Thr Ser Gln Pro Asn Pro 50 55 60Gln Leu Val Gly Ser Ser Lys Tyr His Ser Gln Ser Gln Gly His Thr65 70 75 80Gly Ile Ala Pro Val Arg Ser Asp Tyr Val Gln Asp Gly Gln Gly Ile 85 90 95Val Lys Tyr Leu Gln Asn Gly Ser Gly Gly Asn Gly Arg Ser Ser Gly 100

105 110Glu Pro Val Pro Lys Thr Phe His Cys Ser Thr Cys Ser Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 130 135 140Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 180 185 190Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 195 200 205Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 210 215 220His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr225 230 235 240Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Val Arg Pro Pro Asp 245 250 255Gly Met Tyr Ser Glu Ala Gly Ser Thr Gln Ser Thr Pro Ser Pro Gly 260 265 270Gln Arg His Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Met Tyr Leu 275 280 285Pro Arg Gln Met Ser Asp Tyr Tyr Met Gly Asn Thr Pro Ile Pro Ala 290 295 300His Leu Arg Gly Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro Ser305 310 315 320Thr Ser Ser Pro Pro Leu Ser Thr Tyr Ser Ser Val Pro His Ala Arg 325 330 335Pro Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Val 340 345 350Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Val Ala Gly Ser 355 360 365Pro His Ile Thr Ser Met Gly Trp Ala Ser Pro Thr Leu His Ser Ile 370 375 380Gly Ser Pro Asp Ser Ala Ser Ala Thr Glu Tyr Ser Tyr Pro Glu Pro385 390 395 400Ser Ala Pro Ser Tyr Ser Ser Gln Ile Pro Pro His Met Tyr Phe Pro 405 410 415Asn Ser Thr Ile Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr Glu 420 425 430Leu Lys Pro Lys Leu Asn Gly Asp Ser Trp Thr Thr Pro Val 435 440 44573467PRTArtificial Sequencesynthesized 73Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Ile Val1 5 10 15Ala Ala Asp Val His Gln Leu Gln Gln His Leu Ala Gln Ala Gln Ser 20 25 30Gln Ser Gln Thr Asp Asp Ala Val Lys Ser Arg Ser Pro Ser Glu Leu 35 40 45Gly Ala Ser Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His 50 55 60His His His His His His His His Gln Pro Thr Ser Ser Phe Pro Ser65 70 75 80Ser Thr Gln Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val 85 90 95Gln Ala Gln Ala Asn His Ala Gly Thr Ser Pro Gly Tyr Ala His Ser 100 105 110Ala His Gly Ser Asp Tyr Gly Arg Ser Ser Thr Ser Met Arg Pro Thr 115 120 125Gly Leu Pro Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly 130 135 140Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly145 150 155 160Ile Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile 165 170 175Gln Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys 180 185 190Pro His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 195 200 205Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 210 215 220Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr225 230 235 240Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu 245 250 255Thr Glu Ala Asn Leu Arg His Ser Lys Asp Arg Ser Thr Ala Ser Arg 260 265 270Pro Ser Glu Tyr Ser Glu Pro Gly Ser Ala His Ser Thr Pro Ser Pro 275 280 285Ala Gln Arg Pro Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn 290 295 300Leu Ser Ser Arg Pro Ser Ala Ala Gly Gly Pro Thr Ser Ala Gly Gly305 310 315 320Ser Ala Asp Tyr Tyr Thr Ser Leu Pro Pro His Leu Arg Thr Asp Phe 325 330 335Ala Asn Ser Ser Pro Arg Ala Ser Pro Thr Ser Pro Ser Pro Thr Leu 340 345 350Thr Ser Leu Ser Gly Pro Ala Ser Phe His His His Asn His Asn Arg 355 360 365Pro Ser Leu Thr Ser His Pro Ser Gly Tyr Ala Pro Pro Gln Pro Leu 370 375 380Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Val Ala Gly Ser385 390 395 400Pro His Leu Ser Ser Val Gly Trp Ala Ser Pro Thr Leu Ser Ser Met 405 410 415Pro Ser Pro Ser Ser Ala Ser Ala Pro Glu Tyr Pro Tyr Pro Glu Pro 420 425 430Ser Ser His Gln Tyr Pro Gly Ser Ile Thr Pro His Met Phe Phe Pro 435 440 445Arg Arg Pro Gln Ser Ser Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys 450 455 460Leu Glu Leu46574490PRTArtificial Sequencesynthesized 74Met Gln Tyr Glu Val Pro Leu Pro Ile Ala Met Asn His Asp Val Ser1 5 10 15Thr Ser Asn Gly His Tyr Ala Gln Thr Leu Tyr Val Pro Asn Gly Asn 20 25 30Asn Arg Ile Lys Ser Glu Asn Gly Ser Glu Arg Gly Val Ser Pro His 35 40 45Thr Ser Asp His Ser Ser Arg Tyr Ser Ser Gln Thr Pro Gln Asn Ser 50 55 60Val Ala Tyr Gln Gln Ile Ala Ala Gln Leu Thr Asn Gly Met Arg Tyr65 70 75 80Pro Ser Pro Asn Gln Met Gln Gln Asn Asn Asn Met Pro Met Leu Gln 85 90 95His Ser Tyr His Pro Asn Thr Thr Gln Asp Gln Gly Tyr Gln Thr Gln 100 105 110Ala Gly Ala Thr Met Gly Ala Val Gln Gln Ala Val Pro Gln Ser Thr 115 120 125Asp Gln Thr Ala Met Asp Gly Gly Arg Ala Ser Thr Gly Ser Ser Gly 130 135 140Leu Pro Lys Ala Phe Ala Cys Ser Thr Cys Gln Lys Gly Phe Ala Arg145 150 155 160Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro 165 170 175His Val Cys Asp His Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser 180 185 190Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys Pro His Met 195 200 205Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 210 215 220His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala225 230 235 240Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln 245 250 255Asn His His Thr Gly Thr Ile Glu Glu Ser Glu Ala Ala Thr Ala Ala 260 265 270Ala Leu Ala Ser Arg Val Gln Met Ser Thr Asn Arg Ser Arg Gly Ser 275 280 285Asp Glu Glu Asp Gly Tyr Ser Gly Asp Gly Lys Ser Pro Leu Pro Gln 290 295 300Gln Gln Asp Arg Ala Ala Thr Gly Ser Pro Ala Ala Val Leu Asn Gly305 310 315 320Met Pro Gln Leu Gln Arg Gln Ala Ser Asp Tyr Tyr Met Asn Ala Met 325 330 335Asn Gly Gly Met Ala Ala Val Pro Pro His Leu Arg Asn Ala Met Gln 340 345 350Pro Ser Pro Arg Ala Gln Ser Pro Gln Gln Tyr Pro Met Pro Val Asn 355 360 365Gly Asn Thr Pro Gln Ser Arg Pro Ser Leu Thr Ser Asn Pro Ser Ser 370 375 380Ser Ala His Leu Pro Gln Ile Leu Glu Pro Pro Thr Thr Asn Gly Gln385 390 395 400Gln Gln Thr Gly Ser Gly Asn Asn Ser Pro His Leu Asn Asn Asn Asn 405 410 415Asn Asn Pro Met Asn Gly Trp Gln Ser Pro His Pro Gly Met Pro Ala 420 425 430Asn Ala Ser Gln Thr Thr Asp Tyr Thr Tyr Pro Asp Pro Asn Asn His 435 440 445Tyr Gly Val Ser Asn Val Asn Thr Ala Gln Met Tyr Tyr Gln Gln Gln 450 455 460Gly Val Pro Arg Pro His Ser Thr Gln Pro Leu Asp Tyr Gln His Gln465 470 475 480Gly Gln Pro Met Trp Ala Gln His Gln Gln 485 49075535PRTArtificial Sequencesynthesized 75Met Gln Leu Pro Thr Pro Ser Gly Trp Gly Gln Trp Gln Gln Asn Glu1 5 10 15Val Glu Ser Gly Tyr Val His Met Gly Ser Pro Met Met Gly Thr Gln 20 25 30Ala Pro Leu Pro Gln Pro Thr Leu Ser Pro Gln Tyr Pro Val Thr Leu 35 40 45Ala Pro Ser Pro Ser Leu Gln Gln Pro Met Ser Tyr Gly Pro Tyr Ala 50 55 60His Gly Leu Pro Ser Val Ala Pro Leu Gln Ile Pro Thr Ile Gly Ser65 70 75 80Gln His Ser His His Tyr Gln His Gln His Gln His Gln Gln His Gln 85 90 95Ile Gln Leu Ser Asp Ser Ile Asp Arg Thr Arg Lys Arg Leu Val Asn 100 105 110Arg Arg Ser Leu Arg Asp Thr Thr Met Glu Ile Met Glu Ala Arg His 115 120 125Arg Gly His Thr Thr Pro Glu Arg Ala Thr His Arg Ile Pro Gln Thr 130 135 140Val Val Ala Asn Ala Ser Thr Val Gly Ala Ser His Ala Gly Asn His145 150 155 160Val Glu Phe Asn Thr Ser Val Asp Lys Leu Met Lys Val Ile Gln Ala 165 170 175Met Pro Asp Thr Gly Pro Leu Val Glu Ser Leu Glu Ala Ala Val Lys 180 185 190Gln Glu Leu Pro Gln Val Glu Glu Ser Glu Gln Ala Ala Ser Pro Pro 195 200 205His Glu Ser Lys Pro Ala Lys Gln Lys Ala Ala Met Arg Lys Phe Ala 210 215 220Cys His Phe Arg Gly Cys Gln Lys Lys Phe Ala Gln Lys Ala Gln Leu225 230 235 240Asp Thr His Val Arg Ser His Thr Gly Glu Arg Pro Tyr Val Cys Glu 245 250 255Phe Pro Asn Cys Gly Lys Arg Phe Thr Gln Ser Gly Asn Leu His Thr 260 265 270His Glu Arg Lys His Thr Gly Glu Arg Pro Tyr Val Cys Asp Val Cys 275 280 285Gly Arg Arg Phe Ala Gln Gly Gly Asn Arg Gln Ala His Lys Lys Val 290 295 300His Gln Lys Thr Lys Asp Phe Ile Cys Arg Leu Glu Asn Cys Gly Lys305 310 315 320Glu Phe Thr Gln Arg Gly Asn Leu Lys Asn His Gln Asn Asn Thr His 325 330 335Lys Gln Phe Met Asp Gln Thr Met Ala Arg Leu Glu Arg Ile Ser Pro 340 345 350Glu Asn Met Ser Pro Glu Asp Arg Asp Leu Val Val Tyr Leu Ala Pro 355 360 365Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Ala Arg Pro 370 375 380Ala Gly Tyr Arg Leu Ser Arg Ser Arg Arg Ala Pro Ser Val Ser Ser385 390 395 400Ser Thr Gln Ser Tyr Ser Pro Thr Lys Ser Glu Ala Ser Leu Thr Ser 405 410 415Ser Pro Cys Thr Ala Gly Pro Pro Ser Gln His His Tyr Gly Gly His 420 425 430Ala Gln His Gln Tyr His His Gln Gln His His His His Gln Gln Gln 435 440 445Gln Gln Arg Pro Gln Gln Gly Leu Ala Tyr Pro Pro Val Ser Phe Gly 450 455 460Ser Ala Pro Ser Asp Ser Phe Arg Tyr Pro Tyr Asn Gly Ile Val His465 470 475 480Arg Tyr Glu Met Pro Glu His Ser His Thr Tyr Ser Gly Ile Pro Val 485 490 495Thr Thr Ser Ser Ser Thr Pro Ser Pro Val Ala Thr Val Tyr Ser Asp 500 505 510Asp Ser Gly Ala Val Tyr His Ser Asp Asp Asn Gly Ala Arg Glu Leu 515 520 525Ala Phe Gly Glu Arg Ile Cys 530 53576341PRTArtificial Sequencesynthesized 76Met Val Arg Thr Arg Ser Phe Pro Cys Ser Trp Val Ser Cys Lys Lys1 5 10 15Val Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile His Thr 20 25 30Asn Glu Arg Pro Tyr Arg Cys Asn Phe Pro Asn Cys Thr Lys Ser Phe 35 40 45Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr Gly Glu 50 55 60Lys Pro His Val Cys Asn Phe Ala Asn Cys Ser Lys Ala Phe Ser Asp65 70 75 80Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Arg Arg Pro 85 90 95Tyr Lys Cys Leu Glu Pro Thr Cys Asp Arg Ser Phe Cys Arg Lys Thr 100 105 110Thr Leu Thr Lys His Gln Ser Arg Ser His Gln Pro Glu Ala Val Ser 115 120 125Pro Ser Ala Gln Ser Cys Glu Ser Glu Leu Tyr Ser Gln Pro Thr Gln 130 135 140His Ser Met Ser Met Met Pro Gln Ser Ser Pro Val Ser Gln His Gln145 150 155 160Leu Gln Ser Gln Gln Gln Glu Gln Gln Gln His Gln Gln Gln His Leu 165 170 175Gln Pro Gln Pro Arg Pro Gln Gln His Ser Pro Tyr Gln Gln Gln His 180 185 190Ser Pro Ile Ile Ala Val Pro Val Ser Asp Tyr Phe His His Ala Gln 195 200 205Ser Gln Pro Thr Thr Val His Ser Ile Pro Ile Ser Ala Glu Gln Pro 210 215 220Ile Leu Pro Pro Gln Val His Tyr Val Ser Thr Gly Ile Leu Pro Pro225 230 235 240Gln Ile Pro Arg Tyr Asp Ile Pro Ile Thr Thr Ser Ala Ala Val Ser 245 250 255Ile Pro Thr Thr Ile Asp Gln Leu Thr Tyr Ala His Pro Val Ser Val 260 265 270Ser Met Pro Gln Gln Gln Arg Ile Gln Ala Pro Gln Pro Ile Gln Val 275 280 285Ser His Gln Thr Asp Gly Gly Phe Gln Val Leu Pro Val Val Ala Gly 290 295 300Gly Ala Gly Gly Gln Tyr Met Lys Glu Phe Asp His Met Lys His Gly305 310 315 320Gln Gln Arg Phe Phe Gly Ser Thr Tyr Pro Glu His Met Asn Trp Asp 325 330 335Phe Leu Gly Leu Ser 34077441PRTArtificial Sequencesynthesized 77Met Glu Ile Pro Thr Ile Leu Asn Arg Lys Ala Ser Ala Ala Val Val1 5 10 15Ala Asp Pro Arg Phe Gln Ala Gln Leu Ala Gln Ala Val His Leu His 20 25 30Gln Gln Glu Met Ser Glu Gln Ala Asn Ser Gln Pro Gly Thr His Ala 35 40 45Val Met Gly Tyr Pro Pro Asn Ala Gln Pro Leu His Gln Gly Pro Met 50 55 60Pro Gly Gln His Trp Pro Ile His Pro Asn Gly Ala Pro Met Met Pro65 70 75 80Asn Asn Trp Asp Pro Asn Pro Phe Ala Gly Ala Pro Pro Gln Pro Pro 85 90 95Gln Pro Ser His Thr Pro Pro Val Pro Gln Gln Gln Pro Arg Ala Glu 100 105 110Pro Ala Pro Arg Val Phe His Cys Ser Thr Cys Gln Lys Gly Phe Ala 115 120 125Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg 130 135 140Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg145 150 155 160Ser Ala Leu Thr Val His Ala Arg Val His Thr Gly Glu Lys Pro His 165 170 175Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala 180 185 190Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr 195 200 205Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 210 215 220Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Gln Thr Glu225 230 235 240Ala Ser Leu Arg Gln Asn Arg Glu Lys Ser Ala Arg Ala Ser Glu Gly 245 250 255Ile Tyr Ser Glu Thr Gly Ser Gly His Ser Thr Pro Ser Pro Gly Gln 260 265 270Gln Ala Ala Met Gly Leu Gly Ser Glu Leu Pro Pro

Leu Asn Ile Ile 275 280 285Arg Ser Thr Gly Glu Tyr Tyr Ile Pro Asn Gly Gly Ile Pro Pro His 290 295 300Val Arg Gly Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro Ala Ala305 310 315 320Thr Ser Pro Ala Leu Ser Ser Tyr Ser Ser His Pro Arg Pro Ser Met 325 330 335Thr Ser His Pro Ser Ser Tyr Gly Pro Pro Gln Pro Leu Glu Pro Pro 340 345 350Ala Asn Thr Asp His Arg Pro Gly Ser Val Thr Gly Ser Pro His Met 355 360 365Thr Ser Met Gly Trp Ala Ser Pro Ser His Ala Ser Met Pro Ser Pro 370 375 380Gly Ser Pro His Glu Phe Gly Tyr Pro Glu Pro Ser Val Ala Ala Tyr385 390 395 400Ala Ser Ala Met Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile Arg 405 410 415Arg Pro Gly Ser Thr Glu Pro Glu Asn Tyr Glu Met Lys Pro Lys Ile 420 425 430Gly Pro Asp Gly Trp Ser Thr Pro Ile 435 44078444PRTArtificial Sequencesynthesized 78Met Asp Ile Thr Thr Ile Leu Asn Arg Lys Gly Ser Thr Ala Ala Ile1 5 10 15Ala Ala Glu Ala Gln Phe Gln Gln Gln Phe Val His His Asn Leu Asp 20 25 30Pro Ser Ser Ser Pro Lys Met Lys Pro Glu Pro Gly Val Ser Glu Ala 35 40 45Ser Asp Gln Gln Val Leu Ser Tyr Pro Ser His Ala Pro Leu Asn Pro 50 55 60Met Pro Asn Met Ala Gln Asp Met Arg Tyr Pro Pro His Gly Gln Pro65 70 75 80Asn Ser Gly Met Pro Val Leu Gln Asn Pro Tyr Val Pro Gly Ala Tyr 85 90 95Thr Gly Ser Ala Gln Ile Pro Ser Ser Ala Thr Pro Gln Arg Ala Asp 100 105 110Pro Pro Pro Lys Thr Phe His Cys Ser Thr Cys Gly Lys Gly Phe Ala 115 120 125Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Thr Gly Ile Arg 130 135 140Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg145 150 155 160Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys Pro His 165 170 175Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala 180 185 190Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr 195 200 205Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 210 215 220Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu225 230 235 240Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Arg Ala Pro Gly Asp Gly 245 250 255Val Phe Ser Glu His Ala Ser Val His Ser Thr Pro Ser Pro Ala His 260 265 270His Pro Val Ser Ile Pro Pro Pro Gly Asp Leu Pro Pro Leu Asn Met 275 280 285Pro Arg Ser Ala Gly Asp Tyr Tyr Met Gly Asn Gly Ser Ile Pro Pro 290 295 300His Val Arg Gly Asp Phe Ser Gln Ala Ser Pro Arg Ser Ser Pro Thr305 310 315 320Ala Thr Ser Pro Ser Leu Ser Ser Phe Ser Ser Ala Pro His Gln Arg 325 330 335Pro Ser Met Thr Ser His Pro Ser Gly Tyr Ala Pro Pro Gln Pro Leu 340 345 350Glu Pro Pro Ala Asn Ser Asp His Arg Pro Asn Ser Val Ser Gly Ser 355 360 365Pro His Met Thr Ser Leu Gly Trp Ala Ser Pro Ser His Gly Ser Ile 370 375 380Pro Ser Pro Gly Ser Val Asn Asp Phe Asn Tyr Pro Glu Pro Ser Gly385 390 395 400Pro Ala Tyr Pro Ser Ser Met Pro Pro His Met Tyr Phe Pro Asn Ser 405 410 415Thr Ile Arg Arg Pro Thr Ser Thr Glu Pro Glu Asn Tyr Glu Leu Lys 420 425 430Pro Arg Leu Gly Asp Asn Gly Trp Ser Thr Pro Val 435 44079456PRTArtificial Sequencesynthesized 79Met Glu Thr Ala Glu Pro Val Ser Tyr Glu Phe Pro Gly His Thr Ile1 5 10 15Gly Ala Val Ala Pro Arg Arg Met Met Thr Ser Asn Leu Gly His Asn 20 25 30Phe Pro Phe Tyr Ala Thr Pro Ala Ala Ser Phe Pro Leu Pro Phe His 35 40 45Gln Ser Ser Ser Thr Ala Tyr Gly Phe Gly His Ala Leu Asn His His 50 55 60His His Asn His His Gln Pro Ser Tyr Pro Gln Phe Phe Val Ala Ser65 70 75 80His Glu Ser Ile Asn Ser Gln Pro Met Arg Leu Ser Ser Glu Pro Pro 85 90 95Pro Val Gln Ser Ile Pro Asp Ile Arg Pro Ala Lys Asn Ala Val Asn 100 105 110Arg Val Ser Arg Asp Pro Leu Val Lys Asn Asp Pro Ser Ser Asn Thr 115 120 125Gln Gln Thr Pro Met Ala Arg Ser Ser Thr His Gly Ala Ala Ala Gln 130 135 140Ser Lys Ser Pro Ser Val Ser Glu Ile Glu Phe Thr Thr Glu Val Asp145 150 155 160Ile Leu Met Lys Ala Ile Gln Ser Arg Asn Ser Val Gln Pro Pro Asn 165 170 175Thr Gln Ser Leu Pro Pro Leu Gln Gln Leu Thr His Arg Gly Cys His 180 185 190Gly Tyr Pro Gln Thr Phe Ser Leu His Pro Ser Gly Asn Thr Arg Cys 195 200 205Asn Met Met Ala Glu Glu Val Gln Ser Arg Ser Gly Lys Lys Arg Lys 210 215 220Tyr Val Cys Thr Leu Pro His Cys Gly Lys Ser Phe Ala Gln Lys Thr225 230 235 240His Leu Asp Ile His Thr Arg Ala His Thr Gly Asp Lys Pro Phe Ile 245 250 255Cys Lys Glu Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu 260 265 270Lys Arg Glu Lys Thr Asp Ser Asn Pro Gly Ala His Lys Gln Thr His 275 280 285Gln Arg Arg His Thr Gly Glu Lys Pro Phe Ser Cys Asp Ile Cys Gln 290 295 300Lys Arg Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Thr His305 310 315 320Gln His Ala Lys Pro Phe Thr Cys Leu Leu Asp Asp Cys Gly Lys Gln 325 330 335Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala 340 345 350Thr Thr Leu Arg Asp Leu Thr Leu Lys Phe Ser Gln Val Thr Ile Gly 355 360 365Asp Pro Met Ser Pro Gln Asp Arg Lys Leu Trp Glu Tyr Phe Ala Thr 370 375 380Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg385 390 395 400Arg Ile Ser Pro Thr Ser Arg Ser Gly Pro Gly Lys Arg His Gln Thr 405 410 415Leu Gly Asn Asn Asp Asp Lys Leu Gln Arg Pro Ile Tyr Glu Glu Ser 420 425 430Ser Val Tyr Thr Gly Gly Ser Ser Ser Asp Glu Glu Asp Ala Glu Ala 435 440 445Tyr Tyr Ile Asp Arg Gln Asn His 450 45580423PRTArtificial Sequencesynthesized 80Ser Glu Thr Gly Ser Glu Arg Gly Ala Ser Pro His Thr Ser Asp Gln1 5 10 15Ser Ser Arg Tyr Ser Ser Gln Thr Pro Gln Asn Ser Ala Val Tyr Gln 20 25 30Gln Met Ala Ala Gln Leu Thr Asn Gly Leu Gln Tyr Thr Ala Pro Pro 35 40 45Gln Met Gln Gln Gln Asn Gly Met Ser Leu Leu Gln His Ser Tyr His 50 55 60Pro Ala Thr Gly Gln Glu Pro Ser Tyr Gln Thr Gln Gln Pro Gln Gln65 70 75 80Gln Gln Ser Gln Gln Gln Ser Thr Gln Leu Gly Leu Pro Lys Ala Phe 85 90 95Ser Cys Asn Thr Cys Gln Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala 100 105 110Arg His Glu Arg Ile His Ser Gly Val Arg Pro His Val Cys Glu His 115 120 125Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His 130 135 140Ser Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly145 150 155 160Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His 165 170 175Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr 180 185 190Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly 195 200 205Thr Ile Glu Glu Ser Glu Ala Ala Thr Ala Ala Ala Leu Ala Ser Arg 210 215 220Ala Ser Leu Pro Gln Gln Arg Ser Arg Gly Ser Asp Glu Glu Asn Asp225 230 235 240Phe Ser Ala Asp Gly Lys Ser Pro Met Pro Pro Gln His Asp Arg Pro 245 250 255Ser Ala Ser Pro Ala Asn Gly Met Asn Gly Ala Pro Gln Leu Gln Arg 260 265 270Gln Ala Ser Asp Tyr Tyr Leu Asn Ala Met Asn Gly Gly Met Ala Ser 275 280 285Val Pro Ala His Leu Arg Asn Asp Met Gln Pro Thr Pro Arg Ser Gln 290 295 300Ser Pro Ala Gln Tyr Thr Met Pro Val Asn Pro Pro Gln Ser Arg Pro305 310 315 320Thr Leu Ala Ser Asn Pro Ser Ala Ser Tyr Ala Ser Arg Gln Ile Leu 325 330 335Glu Pro Asn Gly Ala Ser Val Gln Gln Gln Gly Thr Ser Gly Thr Asn 340 345 350Ser Pro His Met Asn Gly Asn Ile Ala Trp Gln Pro Ser His His Gly 355 360 365Leu Pro Thr Thr Gln Thr Thr Asp Tyr Thr Tyr Pro Asp His Thr Gly 370 375 380Tyr Ser Val Ala Asn Pro Met Tyr Tyr Gln Gln Gly Ser Val Gln Arg385 390 395 400Pro His Ser Thr Gly Pro Ile Asp His Tyr Gly Pro Met Arg Gly Gln 405 410 415Glu Met Trp Ala Gln His Gln 42081503PRTArtificial Sequencesynthesized 81Lys Leu Ala Leu Ala Ala Gln Pro Thr Ala Asn Pro Asn Trp Gly Arg1 5 10 15Trp Pro Gln Gln Leu Ser Gly Glu Tyr Thr Met Met Glu Ser Pro Ser 20 25 30Met Leu Pro Phe Asp Ser Arg Thr Ala Thr Thr Ala Pro Leu Gln Arg 35 40 45Pro Ile Met Ala Pro Tyr Met Val Pro Asn Ser Tyr Ser Ser Ala Gln 50 55 60Met Asn Ser Leu Thr Ala Thr His Tyr Gln Ala Pro Asn Pro Tyr Gln65 70 75 80Phe Ser Gly Tyr Gln Gly Pro Pro Thr Pro Pro His Asn Ser Ser Pro 85 90 95Phe Lys Val Glu Tyr His Asp Arg Arg Pro Met Gly Pro Asp Ser Asp 100 105 110Asn Gly Arg Val Pro Ser Tyr His Arg Gly Ala Lys Tyr Ser Tyr Ala 115 120 125Glu Gln Ala Pro Ser Pro Ala Arg Ser Asp Ser Gln Ala Ser Thr Ala 130 135 140Arg Ser Ser Val Asn Asn Pro Thr Leu Cys Ser Lys Thr Ile Thr Ser145 150 155 160Asn Glu Thr Ile Asn Pro Asp Asp Gln Val Asn Phe Glu Thr Glu Val 165 170 175Asp Glu Leu Met Lys Ala Ile Gln Arg Lys Gly Glu Lys Glu Leu Asp 180 185 190Val Ala Gln Gln Pro Leu Thr Pro Gly Met Ser Pro Val Ser Glu Ala 195 200 205Ser Leu Glu Asn Asn Gly Thr Pro Ala Pro Ala Asp Ser Lys Thr Ser 210 215 220Lys Lys Arg Tyr Val Cys Asn Gly Pro Asn Cys Arg Lys Ser Phe Thr225 230 235 240Gln Lys Thr His Leu Asp Ile His Arg Arg Thr His Thr Gly Asp Lys 245 250 255Pro Tyr Thr Cys Glu Phe Pro Gly Cys Lys Leu Thr Phe Ser Gln Leu 260 265 270Gly Asn Leu Lys Thr His Met Arg Arg His Thr Gly Glu Arg Pro Tyr 275 280 285Ser Cys Gly Lys Cys Gly Arg Lys Phe Ala Gln Arg Gly Asn Val Arg 290 295 300Ala His Glu Gln Thr His Gln Gly Leu Lys Pro Phe Ile Cys Arg Leu305 310 315 320Asp Asp Cys Asn Lys Thr Phe Ser Gln Leu Gly Asn Met Lys Thr His 325 330 335Gln Asn Asn Phe His Lys Lys Thr Leu Lys Asn Leu Thr Met Arg Phe 340 345 350Ala Gln Ile Leu Asn Ser Gly Glu Glu Val Pro Glu Ala Glu Arg Glu 355 360 365Leu Phe Glu Tyr Phe Ala Thr His Tyr Lys Asn Ser Asn Lys Gly Ile 370 375 380Lys Gly Arg Gly Lys Ala Arg Thr Val Ala Glu Arg Lys Thr Lys Pro385 390 395 400Ser Gln Ser Pro Pro Thr Asn Pro Asn Thr Val Thr Pro Gln Tyr Pro 405 410 415Leu Pro Gln Ile Pro Pro Thr Gln Gln Ile Pro Ser Pro His Gln Pro 420 425 430His Gly Leu Ser His Pro Gly Ser Leu Ala Ala Tyr Ser Met Ser Arg 435 440 445Gly His Pro Asn Val Ile Asn Asn Met Pro Arg Glu Ser His Ala Gly 450 455 460Gly Tyr Glu Met Tyr Asp Met Gln Gly Gly His His His Val Gln Pro465 470 475 480Ser Asn Asn Asn Gly Met Met Tyr Glu Glu Glu His Ala Arg Glu Met 485 490 495Gly Phe Asn Glu Arg Met Tyr 50082446PRTArtificial Sequencesynthesized 82Met Gln His Glu Gln Leu Gln Gln His Phe Gly Pro Thr Ser Phe Leu1 5 10 15Asn Gly Arg Ile Lys Ser Glu Asn Gly Ser Asp Arg Gly Val Ser Pro 20 25 30His Pro Ser Asp Ser Ser Arg Tyr Ser Ser Gln Ala Pro Gln Pro Leu 35 40 45Gln Ser Tyr Pro Pro Pro Met Thr Asn Asn Met Asn Gly Met Arg Tyr 50 55 60Pro Ser Pro Ser Gln Met Asn Thr Pro Met Pro Met Leu Asn Asn Asn65 70 75 80Asn Tyr Ile Pro Asn Pro Pro Glu His Ala Tyr Pro Gln Gln Ala Thr 85 90 95Pro Asp Pro Gln Gln Gln His Leu Gly Gly Arg Pro Ala Ser Asp Thr 100 105 110Gly Pro Pro Lys Ala Phe Ala Cys Ser Thr Cys Ala Lys Gly Phe Ala 115 120 125Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg 130 135 140Pro His Val Cys Asp His Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg145 150 155 160Ser Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His 165 170 175Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala 180 185 190Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr 195 200 205Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 210 215 220Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala225 230 235 240Ala Ala Leu Ala Ser Arg Ala Ser Ala Pro Ser Arg Ser Ala Arg Ser 245 250 255Asp Ala Asp Glu Tyr Ser Glu Thr Ala Ser Pro Leu Gly Thr Pro Ser 260 265 270Pro His Glu Arg Pro Leu Ser Leu Ser Pro Ala Asn Gly Met Pro Val 275 280 285Val Pro Ala Met His Arg Gln Ala Ser Asp Tyr Ala Tyr Met Gly Ser 290 295 300Met Asn Val Pro Pro His Leu Arg Asn Glu Met Pro Gln Pro Ser Pro305 310 315 320Arg Ser Ser Pro Ala Leu Thr Ser Gln Ser Tyr Asn Ser Ala Val Ser 325 330 335Asn Thr Arg Pro Thr Ile Thr Ser His Pro Ser Gly Tyr Gly Pro Pro 340 345 350Pro Ile Leu Glu Pro Pro Ala Ser Ala Asn His Asn Gln Pro Gly Ser 355 360 365Val Asn Gly Ser Pro His Met Gly Ala Met Gly Trp Gln Ser Pro Ser 370 375 380Gln Gln Ala Met Pro Ser Pro Gly Pro Gly Asp Asn Tyr Val Tyr Pro385 390 395 400Glu Pro His Tyr Ala Asn Asn Gly Ser Asn Met Tyr Tyr Ala Asn Ser 405 410 415Asn Ile Arg Arg Pro Asn Ser Thr Glu Pro Asp Gln Tyr Asn Pro Gln 420 425 430Gln Gln Arg Met Ala Gly Asp Met Trp Ala Pro Pro Val Gln 435 440 44583442PRTArtificial Sequencesynthesized 83Met Asp Ile Thr Thr Ile Leu Asn Arg Lys Ala Ser Val Ala Met Val1 5 10

15Ala Pro Asp Ala Gln Phe Asp Gln Gln Gln Phe Met Gln Ala Ser Asn 20 25 30Leu Asn Thr Ser Pro Ser Pro Gly Met Lys Ser Glu Pro Asn Val Ser 35 40 45Glu Ala Ala Asn Gln Ser Val Leu Ser Tyr Pro Pro His Ala Pro Met 50 55 60Asn Gln Pro Pro Asn Met Asn Gln Asp Ile Arg Tyr Ala Val Gln Gln65 70 75 80Pro Asn Pro Gln Leu Pro Met Leu Gln Ser Pro Tyr Ala Pro Ser Gly 85 90 95Tyr Ser Ala Ala Ser Val Pro Ile Ser Ala Pro Gln Gly Arg Pro Glu 100 105 110Pro Pro Pro Lys Thr Phe His Cys Gly Thr Cys Gly Lys Gly Phe Ala 115 120 125Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg 130 135 140Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg145 150 155 160Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys Pro His 165 170 175Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala 180 185 190Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr 195 200 205Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 210 215 220Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu225 230 235 240Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Lys Val Pro Gly Asp Gly 245 250 255Met Phe Ser Asp His Gly Ser Val His Gly Ser Val His Ser Thr Pro 260 265 270Ser Pro Ala His His Pro Ile Ser Pro Gly Gly Glu Leu Pro Pro Leu 275 280 285Thr Ile Pro Arg Ser Thr Gly Glu Tyr Tyr Leu Gly Asn Gly Ser Ile 290 295 300Pro Ala His Val Arg Gly Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser305 310 315 320Pro Thr Ala Thr Ser Pro Ser Leu Ser Ser Tyr Ser Ser Ala Pro Leu 325 330 335Pro Arg Pro Ser Met Thr Ser His Pro Ser Thr Tyr Ala Pro Pro Gln 340 345 350Pro Leu Glu Pro Pro Ala Thr Lys Asp His Arg Pro Asn Ser Val Gly 355 360 365Gly Ser Pro His Met Ser Ser Leu Gly Trp Pro Ser Pro Ser His Ser 370 375 380Pro Val Ser Ala Pro Asp Phe Gly Tyr Pro Glu Pro Ser Gly Pro Pro385 390 395 400Tyr Pro Gly Ser Val Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile 405 410 415Arg Arg Pro Ala Ser Thr Glu Pro Glu Asn Tyr Glu Leu Arg Pro Arg 420 425 430Leu Gly Asp Asn Ser Trp Ser Thr Pro Ala 435 44084460PRTArtificial Sequencesynthesized 84Met Asp Ile Thr Thr Ile Leu Asn Arg Lys Ala Ser Val Ser Val Val1 5 10 15Ala Ala Asp Val His Arg Leu Gln Gln His Ile Val His Ala Gln Ala 20 25 30Gln Thr Asp Asp Val Leu Lys Ser Arg Ser Pro Ser Glu Met Gly Ser 35 40 45Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His His His His 50 55 60His His His His Gln Pro Thr Ser Ser Phe Pro Ser Ser Thr Gln Ser65 70 75 80Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val Gln Ala Gln Ala 85 90 95Asn His Ser Ser Pro Asn Pro Gly Tyr Ala His Ser Ala His Gly Ser 100 105 110Asp Tyr Gly Arg Ser Ser Gly Gly Asn Met Arg Pro Thr Gly Leu Pro 115 120 125Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly Phe Ala Arg 130 135 140Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro145 150 155 160His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser 165 170 175Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro His Met 180 185 190Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 195 200 205His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 210 215 220Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln225 230 235 240Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala 245 250 255Asn Leu Arg His Ser Lys Asp Arg Thr Thr Thr Thr Arg Pro Ser Asp 260 265 270Tyr Ser Glu Pro Gly Ser Ala His Ser Thr Pro Ser Pro Ala Gln Arg 275 280 285Pro Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn Leu Ser Arg 290 295 300Pro Ser Ala Gly Pro Thr Ser Ser Gly Gly Ala Asp Tyr Tyr Thr Ser305 310 315 320Leu Pro Pro His Leu Arg Thr Asp Phe Ala Asn Ser Ser Pro Arg Ala 325 330 335Ser Pro Thr Ser Pro Ser Pro Thr Leu Thr Ser Leu Ser Gly Pro Ala 340 345 350Ser Phe His His His Asn His Asn Arg Pro Ser Leu Thr Ser His Pro 355 360 365Ser Gly Tyr Ala Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Ser Asp 370 375 380Pro Arg Pro Asn Ser Val Ala Gly Ser Pro His Leu Ser Ser Val Gly385 390 395 400Trp Ala Ser Pro Thr Leu Ser Ser Met Pro Ser Pro Ser Ser Ala Ser 405 410 415Ala Pro Glu Tyr Ser Tyr Pro Glu Pro Ala Ser His Gln Tyr Pro Gly 420 425 430Gly Ile Thr Pro His Met Phe Phe Pro Arg Arg Pro Gln Ser Ser Glu 435 440 445Pro Glu Asn Tyr Glu Met Lys Pro Lys Leu Glu Leu 450 455 46085439PRTArtificial Sequencesynthesized 85Met Ser Pro Ser Pro Thr Pro Gln Pro Trp Asp Gln Trp Ser Gln Gln1 5 10 15Gln Gln Gln Gln Gln Gln Pro Gln His His Ser Gly Tyr Pro Leu Met 20 25 30Asp Gln Ser Val Phe Pro Gln Tyr Ala Pro Pro Pro Thr Gln Tyr Asp 35 40 45Pro Arg Thr Ser Gln Tyr Asp Pro Arg Thr Val Val Thr Ser Gly Pro 50 55 60Leu Ile Ala Pro His Met Ala Pro His Tyr Val Thr Ala Pro Ala Tyr65 70 75 80Gly Val Ser Pro Ile Ser Asn Met Lys Pro His Phe Ser Thr Gln Thr 85 90 95His Tyr Ser Tyr Gly Gln Tyr Asp Gln Pro Thr Gly His Leu Ala Met 100 105 110Pro Tyr Ser Arg Met Ser Pro Gln Gln Glu Arg Leu Gly Leu Pro Met 115 120 125Val Ser Gln Met Pro Gln Gln Gln His Leu His Ser Gln Gln Arg Gln 130 135 140Gln Arg Ser Pro Ser Ala Ala Arg Ser Glu Thr Leu Ser Ala Pro Lys145 150 155 160Thr Pro Asp Pro Met Asn Thr Lys Glu Ile Thr Tyr Asn Lys Pro Val 165 170 175Met Thr Asp Asp Val Val Phe Thr Thr Pro Val Asp Val Met Met Lys 180 185 190Ala Leu Gln Lys Arg Lys Asp Lys Glu Asp Leu Ala Ser Ser Asn Ser 195 200 205Ser Glu Val Gly Ala Gly Ser Val Lys Ser Glu Pro Ser Ser Pro His 210 215 220Pro Ser Ser Thr Asp Gly Ser Gln Glu Thr Thr Asp Lys Val Lys Lys225 230 235 240Tyr Arg Cys Pro Tyr Asp Gly Cys Pro Lys Ser Phe Gln Gln Ser Thr 245 250 255His Leu Glu Thr His Lys Arg Ala His Thr Gly Asp Lys Pro Tyr Lys 260 265 270Cys Glu Trp His Gly Cys Gly Arg Arg Phe Ser Gln Pro Gly Asn Leu 275 280 285Lys Thr His Thr Arg Leu His Thr Gly Glu Arg Pro Phe Glu Cys Glu 290 295 300Met Cys Gly Ala Cys Phe Ala Gln Arg Gly Asn Leu Thr Ala His Lys305 310 315 320Ala Thr His Ser Lys Thr Lys Pro Phe Val Cys Lys Leu Asp Thr Cys 325 330 335Asn Lys Cys Phe Thr Thr Arg Gly Asn Leu Lys Asn His Gln Asn Lys 340 345 350Tyr His Lys Glu Thr Ile Ala Gln Leu Val Asp Trp Ile Ile Ser Leu 355 360 365Thr Asp Val Asp Ala Leu Ser Ala Lys Asp Arg Asp Leu Leu Trp Tyr 370 375 380Phe Ser Asn Ile Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly385 390 395 400Arg Asp Arg Arg Val Ser Glu Val Arg Met Gly Lys Thr Lys Leu Ser 405 410 415Ser Pro Gly Met Gly Leu Pro Arg Ser Lys Met Leu Asp Ser Ser Phe 420 425 430Ser Arg Leu Gly Leu Gly Phe 43586405PRTArtificial Sequencesynthesized 86Met Lys Pro Glu Pro Gly Val Pro Glu Ala Pro Asp Gln Gln Val Leu1 5 10 15Ser Tyr Pro Pro His Ala Pro Leu Asn Ser Met Pro Ser Met Val Pro 20 25 30Asp Met Arg Tyr Ser Gln Gly Gln Pro Asn Ser Gly Met Pro Leu Leu 35 40 45Gln Asn Ala Tyr Val Pro Gly Val Tyr Thr Thr Asn Ala Gln Ile Pro 50 55 60Asn Gly Ala Thr Pro Gln Arg Ala Asp Pro Pro Pro Lys Thr Phe His65 70 75 80Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg 85 90 95His Glu Arg Ile His Thr Gly Ile Arg Pro His Ala Cys Asp Trp Pro 100 105 110Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser 115 120 125Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys 130 135 140Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser145 150 155 160Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe 165 170 175Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr 180 185 190Ile Glu Glu Ala Ala Ala Glu Thr Glu Ala Asn Leu Arg Gln Asn Lys 195 200 205Glu Arg Ala Arg Val Pro Gly Asp Gly Ala Phe Ser Glu His Ala Ser 210 215 220Val His Ser Thr Pro Ser Pro Ala His His Pro Ala Ala Asn Pro Pro225 230 235 240Pro Gly Asp Leu Pro Pro Leu Asn Met Pro Arg Ser Thr Gly Asp Tyr 245 250 255Tyr Met Gly Asn Gly Ser Ile Pro Pro His Val Arg Gly Asp Phe Ser 260 265 270Gln Ala Ser Pro Arg Ala Ser Pro Thr Ala Thr Ser Pro Ser Leu Ser 275 280 285Ser Phe Ser Asn Ala Pro His Pro Arg Pro Ser Met Thr Ser His Pro 290 295 300Ser Gly Tyr Ala Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Ser Asp305 310 315 320His Arg Pro Asn Ser Val Ser Gly Ser Pro His Met Thr Ser Leu Gly 325 330 335Trp Ala Ser Pro Ser His Gly Ser Ile Pro Ser Pro Gly Ser Val Asn 340 345 350Asp Phe Asn Tyr Pro Glu Pro Ser Gly Pro Ala Tyr Pro Asn Ser Met 355 360 365Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile Arg Arg Pro Gly Ser 370 375 380Thr Glu Pro Glu Asn Tyr Glu Met Lys Pro Arg Leu Gly Asp Asn Gly385 390 395 400Trp Ser Thr Pro Val 40587463PRTArtificial Sequencesynthesized 87Met Ser Asp Pro Arg Pro Ala Val Ser Pro Thr Val Ser Val Ser Gly1 5 10 15Ala Gly Ala Ala Ala Leu Gln Ser His Met Ser Leu Glu Ala Val Lys 20 25 30Gln Glu Thr His Gly Leu Gln Pro Leu Gln Gln His Tyr His His Gln 35 40 45Leu Ala Pro Gly Pro Met Asp Arg Ala Asp Ser Pro His Gly Ser Glu 50 55 60His Ser Arg Tyr Ser Val Pro Pro Leu Asn Gly Met Asp Gln Pro Arg65 70 75 80Pro Tyr Gly Ser Pro Thr Ala Met His Ala Pro Leu His Leu Ser Asp 85 90 95Met Asn Arg Pro Pro Thr Ser Leu Pro Met Asn Ser Leu Pro Leu Pro 100 105 110Ala Ile Gln Pro Thr Leu Ala Pro Ala Pro Gln Ala Ala Gly Ala Val 115 120 125Tyr Gly Ser Gln Glu Thr Pro Gln Pro Pro Pro Lys Ala Tyr Pro Cys 130 135 140Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His145 150 155 160Glu Arg Ile His Ser Gly Val Arg Pro His Ile Cys Glu Phe Pro Gly 165 170 175Cys Asn Lys Lys Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln Arg 180 185 190Val His Thr Gly Glu Lys Pro His Gln Cys Glu Arg Cys Gly Lys Pro 195 200 205Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly 210 215 220Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr225 230 235 240Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile 245 250 255Glu Glu Ala Ala Ala Ala Thr Arg Glu Ala Leu Ala Arg Gly Pro Thr 260 265 270Gly Thr Ala Arg Met Thr Pro Thr His Val Thr Arg Ser Glu Gly Asp 275 280 285Ala Gly Ser Gly Ser Asn His Ala Ser Pro Met Ser Thr Pro Ser Pro 290 295 300Ala His Arg Thr Asn Ser Met Ser Pro Ser Asn Glu Leu Ala Gly Ile305 310 315 320Gly Ser Ile Gln Ser Gln Tyr Val Asn Asn Ser Leu Pro Ser His Leu 325 330 335Arg Gly Asp Val His Ala Ala Ser Pro Thr Ser Thr Thr Ser Ser Gly 340 345 350Tyr Thr Asn Asn Arg Pro Thr Ser His Pro Thr Gly Tyr Gly Pro Pro 355 360 365Gln Val Leu Glu Pro Asn Val Glu Thr Arg Pro Gly Pro Gly Ser Ala 370 375 380Ser Gly Ser Pro His Leu Gly Ser Val Gly Trp Gln Ser Pro Ser His385 390 395 400Val Gly Ser Pro Ser His Ser Thr Ser Gly Phe Val Tyr Pro Asp Pro 405 410 415Glu Ala Tyr Pro Ser Ser Ala Gly Met Gly Pro Leu Phe Tyr Ser Asn 420 425 430Ala Ile Ala Gly Val Arg Ser Gly Ser Ala Glu Pro Gly Gln Asn Asn 435 440 445Asp Tyr Pro Lys Ser Arg Ser Ser Glu Leu Trp Ala Ser Ala Gln 450 455 46088462PRTArtificial Sequencesynthesized 88Met Leu Pro Leu Asp Ser Arg Thr Thr Thr Thr Gly Pro Pro Gln Arg1 5 10 15Pro Ala Met Ala Pro Tyr Met Met Tyr Gln Ser His Gly Pro Gly Pro 20 25 30Val Asn Ser Phe Ala Ala Ser Tyr Tyr Gln Thr Pro Asn Pro Tyr Gln 35 40 45Phe Gly Glu Tyr Gln Gly Pro Pro Thr Pro Pro His Leu Val Ala Pro 50 55 60Pro Lys Ile Gln Tyr Tyr Asp His Asn Ala Val Gly His Asp Lys Asp65 70 75 80Asp Gly Arg Thr Pro Ser Tyr Pro Arg Glu Met Glu Tyr Thr Tyr Ala 85 90 95Glu Gln Ala Pro Ser Pro Ala Arg Ser Asp Leu Gln Ala Ser Thr Val 100 105 110Arg Tyr Ser Gly Thr Lys Pro Ser Met Thr Ser Lys Thr Ile Ile Ser 115 120 125Asn Glu Thr Leu Asn Pro Gly Asp Gln Thr Asn Phe Val Thr Glu Val 130 135 140Asp Glu Leu Met Lys Val Ile Gln Arg Lys Ala Asp Leu Gln Val Gly145 150 155 160Ala Gly Gln Gln Pro Leu Ala Pro Val Met Ser Ser Val Ser Val Ile 165 170 175Ser Gln Gly Thr Pro Gly Ser Ile Asp Asn Lys Thr Ala Arg Lys Arg 180 185 190Tyr Arg Cys Asp Gly Pro Ser Cys Gln Lys Ser Phe Thr Gly Lys Thr 195 200 205His Leu Asp Ile His Arg Arg Thr His Thr Gly Ile Lys Pro Tyr Ile 210 215 220Cys Asp Phe Pro Gly Cys Asp Leu Thr Phe Ser Gln Leu Gly Asn Leu225 230 235 240Lys Thr His Lys Arg Arg His Thr Gly Glu Arg Pro Phe Ala Cys Glu 245 250

255Gln Cys Asp Arg His Phe Ser Gln Arg Gly Asn Leu Gln Ala His Leu 260 265 270Glu Ser His Lys Gly Leu Lys Pro Phe Ile Cys Ile Leu Asp Asp Cys 275 280 285Asn Lys Thr Phe Thr Leu Leu Gly Asn Met Lys Thr His Gln Asn Ser 290 295 300Leu His Lys Glu Thr Leu Glu Glu Leu Thr Met Lys Phe Thr Lys Ile305 310 315 320Ile Ala Ser Gly Glu Lys Val Cys Glu Ala Asp Arg Glu Leu Phe Glu 325 330 335Tyr Phe Ala Thr His Tyr Lys Asn Ser Asn Lys Gly Ile Arg Gly Arg 340 345 350Gly Asp Ala Arg Thr Val Ala Asp His Lys Thr Arg Met Glu Met Asn 355 360 365His Pro Val Asn Thr Met Thr Ala Val Pro Gln His Pro Leu Pro Gln 370 375 380Ile Val Ser Thr Pro Ile Pro Leu His Gly Leu Pro Val Ser Val Ser385 390 395 400Leu Ala Ser Tyr Ser Val Ser Arg Val Gln Pro Gly Pro Ile Asn Pro 405 410 415Met Ser Thr Gln Thr His Ala Gly Gly Tyr Glu Met Tyr Asp Met Asn 420 425 430Gly His His Arg Ile Gln Pro Leu Asn Ser His Gly Leu Ser Tyr Asp 435 440 445Thr Asn Ser Ala Arg Glu Met Gly Tyr His Glu Arg Met Tyr 450 455 46089440PRTArtificial Sequencesynthesized 89Met Asp Phe Thr Thr Ile Leu Asn Arg Lys Asn Ser Ala Ala Ala Ala1 5 10 15Ala Ala Ala Glu Ala Gln Leu Gln Gln Gln Tyr Phe Gln Gln Ser Ala 20 25 30Gln Leu His Thr Gly Ala Ser Pro Thr Met Lys Ser Glu Ser Gly Gly 35 40 45Ser Asp Asn Pro Val Asn Ala Tyr Pro Pro His Gly Pro Pro Pro Met 50 55 60Gln Met Asp Ala Gly Leu Ala Asp Ser Phe Tyr Tyr Ala Gln Pro Thr65 70 75 80Gly Ser Thr Pro Arg Asn Met Ala Tyr Ala Pro Ala Gly Tyr Ala Gly 85 90 95Asp Pro Gln Met Gln Gln Glu Pro Val Pro Gln Gly Arg Ala Gly Val 100 105 110Glu Pro Pro Pro Lys Thr Phe His Cys Ser Thr Cys Asn Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Thr Gly Val 130 135 140Arg Pro His Ala Cys Glu Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 180 185 190Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 195 200 205Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 210 215 220His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr225 230 235 240Glu Ala Gln Leu Arg Gln Asn Lys Asp Arg Gly Arg Pro Gly Glu Gly 245 250 255Met Phe Ser Glu His Ala Ser Ile His Ser Thr Pro Ser Pro Ala Gln 260 265 270His Pro Ser Met Ser Pro Gly Gly Glu Leu Pro Pro Leu Asn Met His 275 280 285Arg Ser Ala Gly Asp Tyr Tyr Met Gly Thr Gly Pro Ile Pro Pro His 290 295 300Val Arg Gly Asp Phe Pro Gln Gly Ser Pro Arg Ala Ser Pro Thr Ala305 310 315 320Thr Ser Pro Ser Leu Ser Ser Tyr Gly Ser Ala Pro His Thr Arg Pro 325 330 335Ser Met Thr Ser His Pro Tyr Ala Pro Pro Gln Pro Leu Glu Pro Pro 340 345 350Ala Asn Ser Asp His Arg Pro Asn Ser Val Asn Gly Ser Pro His Met 355 360 365Thr Ser Leu Gly Trp Ala Ser Pro Ser His Gly Ser Met Pro Ser Pro 370 375 380Gly Ser Ala Asn Asp Phe Thr Tyr Pro Glu Pro Thr Gly Pro Ala Tyr385 390 395 400Pro Thr Ser Met Pro Pro His Met Tyr Phe Pro Asn Ser Thr Ile Arg 405 410 415Arg Pro Thr Ser Thr Glu Pro Glu Asn Tyr Glu Met Lys Pro Arg Gly 420 425 430Asp His Ser Trp Ser Thr Ala Val 435 44090395PRTArtificial Sequencesynthesized 90Met Ala Glu Asp Pro Glu Arg Pro Arg Pro Phe Leu Cys Asp Trp Gln1 5 10 15Gly Cys Gly Lys Arg Phe Asn Arg Lys Ser Asp Leu Gln Arg His His 20 25 30Arg Ile His Thr Asn Glu Arg Pro Tyr Gly Cys Asn Trp Gln Asp Cys 35 40 45Gly Lys Arg Phe Ile Gln Arg Ser Ala Leu Thr Val His Leu Arg Thr 50 55 60His Thr Gly Glu Lys Pro His Gln Cys Glu Val Pro Glu Cys Arg Lys65 70 75 80Pro Phe Ala Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Arg 85 90 95Gly Glu Lys Pro Tyr Arg Cys Gln Asp Val Gly Cys Asn Lys Ala Lys 100 105 110Thr Thr Arg Asp Lys His His Thr Asn Ser His Arg Gly Gly Ile Asn 115 120 125Arg Ser Met Thr Pro Arg Gln Gln Leu His Pro Ser Phe Gly Ser Gly 130 135 140Phe Asp Gln Phe His Met Ser Ala Pro Pro Glu Leu Thr Ala Ser Thr145 150 155 160Asp Ser Ser Pro Ala Asp Ser Thr Ala Tyr Ser Pro Ala Ala Leu Glu 165 170 175Gly Asp Trp Ser Ser Gln Asn Phe Asn Asn Tyr Thr His Met Pro Asn 180 185 190Leu Gln Glu Ala Ser Ile Ala Leu Gln Asn Gln Ile Arg Ser Gln Gln 195 200 205Ile Pro Gln Leu Met Pro Tyr Met Ser Ser Arg Val Val Pro Ser Tyr 210 215 220Ser Ala Pro Pro Pro Asn Met Met Gly Gln Gln Met Pro Gln Gln Gly225 230 235 240Ser Phe Ser Ser Tyr Ser Pro Ser Pro Val Asp Ser Thr Gln Gln Gln 245 250 255Pro Trp Ala Thr Gly Leu Gln Asn Asn Gln Arg His Tyr Gln Arg Val 260 265 270Leu Thr Ser Asn Asp Thr Ala Pro Arg Met Phe Ser Pro Tyr Pro Ala 275 280 285Pro Pro Asn Met Met Thr Ser Gln Asn Asp Phe Asn Asn Gln Tyr Pro 290 295 300Pro Pro Gln Gln Gln Gln Ser Trp Gly Met Pro Gln Asn Gln Gly Gln305 310 315 320Gln Asp Gln Arg His Tyr Ser Leu Ser Ser Pro Ser Gln Pro Leu Thr 325 330 335Pro Val Pro Val Ser Ala Gly Pro Gly Thr Met Gln Pro Leu Gln Ser 340 345 350Met Pro Gly His Ile Tyr Gly Ala Arg Leu Val Gly Asp Asp Leu Ser 355 360 365Asp His Phe Phe Lys Val Glu Thr Thr Ala Asp Glu Asn Asn Pro Gly 370 375 380Met Thr Leu Pro Asp Ala Arg Phe Ala Gly Leu385 390 39591471PRTArtificial Sequencesynthesized 91Met Ser Asn Ile Asn Gln Asn Gln Asn Pro Gly Ala Asn Gly Gly Ala1 5 10 15Ser Met Asp Ile Thr Asn Ile Leu Asn Thr Lys Gly Gly Ala Ala Ala 20 25 30Ala Ala Ala Ala Ala Gly Ala Ser Pro Ser Asp His Thr Phe His Gln 35 40 45Gln Leu Met His Ala Ser Gly Gly Gln Ala Asn Ser Glu Thr Ala Ser 50 55 60Glu Arg Gly Gly Ser Pro His Gly Ser Glu His Ser Ser Arg Tyr Ser65 70 75 80Gly Pro Pro Ser Met Gly His Met Asn Gly Met Gly Asn Gly Met Arg 85 90 95Tyr Pro Ser Pro Thr Ala Met Gln Ser Pro Leu Pro Met Gln Ala Gly 100 105 110Phe Arg Asn Asp Gly Phe Asp Gly Ser Ala Pro Gln His Gln Glu Ile 115 120 125Pro Arg Ser Thr Gly Arg Leu Pro Pro Gly His Gly Val Thr Gln Gln 130 135 140Lys Ala Phe Pro Cys Thr Val Cys Gln Lys Gly Phe Ala Arg Arg Ser145 150 155 160Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Val 165 170 175Cys Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu 180 185 190Thr Val His Ala Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu 195 200 205Arg Cys Gly Lys Arg Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg 210 215 220Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys225 230 235 240Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His 245 250 255His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu 260 265 270Ala Ser Arg Ala Gly Ser Asn Arg Ser Gly Arg Gly Pro Arg Ser Asp 275 280 285Gly Glu Gln Tyr Ser Ala Thr Gly Ser Pro Met Ser Thr Pro Ser Pro 290 295 300Gly Gln Arg Thr His Ser Met Ser Pro Asn Ala Glu Leu Ala Pro Met305 310 315 320Asn Gly Met Gln Arg His Met Gly Asp Tyr Pro Tyr Met Asn Asn Ser 325 330 335Ser Leu Pro Val His Leu Arg Asn Asp Tyr Ala Gln His Val Pro Met 340 345 350Gln Asn Ala Pro Leu Pro Gln Lys Gln Ser Gln Tyr Pro Asn Asn Gln 355 360 365Arg Pro Thr Ser His Pro Thr Gly Tyr Gly Pro Pro Gln Ile Leu Glu 370 375 380Pro Pro Ala Asn Pro Gln Ser Ala Gly Ser Ala Ser Gly Gly Ser Pro385 390 395 400His Met Ser Asn Ala Gly Trp His Ser Pro Ser Asn Met Pro Ser Pro 405 410 415Thr Ser Gln Ser Asn Gly Tyr Val Tyr Pro Asp Pro Asp Pro Tyr Gly 420 425 430Ser Gly Gly Met Gly His Met Tyr Tyr Pro Asn Ser Asn Ile Arg Arg 435 440 445Pro Gln Ser Thr Glu Pro Asp Ser Tyr Glu Thr Lys Pro Arg Leu Asn 450 455 460Glu Leu Trp Thr Ala Ala Gln465 47092424PRTArtificial Sequencesynthesized 92Met Val Ala Ala Asp Thr Pro Phe Asp Pro Ala His Leu Val Pro Asn1 5 10 15Pro Gly Met Asp His Ser Pro Lys Met Lys Ala Glu Pro Gly Ala Glu 20 25 30Ser Thr Asp Gln Gln Val Leu Ser Tyr Pro His His Ala Gln Leu Ser 35 40 45Gln Met Pro Ser Met Gln Gln Asp Leu Arg Tyr Ala Pro Gln Ala His 50 55 60Pro Asn Gln Gly Leu Pro Leu Leu Gln Asn Thr Phe Ile Pro Gly Ala65 70 75 80Tyr Ala Gly Ala Gly Gln Leu Pro Ala Asn Val Pro Gln Gly Arg Pro 85 90 95Asp Pro Pro Pro Lys Thr Phe His Cys Gly Thr Cys Ser Lys Gly Phe 100 105 110Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 115 120 125Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln 130 135 140Arg Ser Ala Leu Thr Val His Ala Arg Val His Thr Gly Glu Lys Pro145 150 155 160His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 165 170 175Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 180 185 190Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 195 200 205His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr 210 215 220Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Ala Arg Val Ser Gly Asp225 230 235 240Met Phe Ser Asp His Gly Ser Val His Ser Thr Pro Ser Pro Ala His 245 250 255His Pro Val Ser Pro Val Gly Asp Leu Pro Pro Leu Asn Met Pro Arg 260 265 270Ser Asp Tyr Tyr Met Thr Asn Gly Ser Ile Pro Pro His Val Arg Gly 275 280 285Gly Phe Pro Gln Val Ser Pro Arg Ala Ser Pro Thr Ala Thr Ser Pro 290 295 300Ser Leu Ser Ser Tyr Gly Ser Ala Pro His Val Arg Pro Ser Met Thr305 310 315 320Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu Glu Pro Pro Ala 325 330 335Asn Asn Asp His Arg Pro Asn Ser Val Ser Gly Ser Pro His Met Thr 340 345 350Ser Leu Gly Trp Ala Ser Pro Ser His Ser Ser Ile Pro Ser Pro Gly 355 360 365Ser Ala Thr Asp Phe Gly Tyr Pro Glu Pro Ser Gly Ala Ala Tyr Ala 370 375 380Ser Ser Met Pro Pro His Met Tyr Phe Pro Ser Ser Thr Ile Arg Arg385 390 395 400Pro Ala Ser Thr Glu Pro Asp Asn Tyr Glu Met Lys Pro Arg Leu Gly 405 410 415Asp Ser Ala Trp Ser Thr Pro Val 42093555PRTArtificial Sequencesynthesized 93Met His Thr Tyr Thr Asp Met Tyr Thr Phe Ala His Arg Leu His Thr1 5 10 15Pro Arg Ser Val Gln Ser Glu Cys Ala Ser Thr Cys Arg Ala Arg Leu 20 25 30Leu Ser Arg Val Pro Pro Ile Trp Arg Gly Thr Tyr Pro Thr Asn Arg 35 40 45Met Ala Leu Thr Ala Gln Pro Ser Ala Pro Ala Gly Trp Glu Arg Trp 50 55 60Pro Gln His His Pro Ser Asn Asp Tyr Val Met Met Asp Ala Asp Val65 70 75 80Met Pro Tyr Asn Ala Arg Pro Met Thr Thr Ala Pro Met Gln Gln Arg 85 90 95Pro Ser Leu Val Pro His Tyr Met Pro Thr Thr Ser Met Ser Thr Ala 100 105 110Ser Ile Asn Ser Ile Ser Ala Pro Ala His Tyr Gln Ser Pro Val Ser 115 120 125Tyr Gly Gly Gly Tyr Pro Ala Tyr Pro Leu Pro Thr Pro Thr Thr Met 130 135 140Asn Ser Ser Tyr Asn Lys His Gln Gln Tyr Gln Glu Arg Pro Ser Leu145 150 155 160His Met Ile Thr Pro Glu Phe Glu Glu Thr Arg Gly Pro His His Ile 165 170 175Arg Asn Ala Arg Arg Tyr Ser Glu Glu Ser Arg Ser Pro Ser Glu Arg 180 185 190Ser Asp Ser Gln Gly Ser Thr Thr Glu Thr Thr Ile Ser Asn His Ser 195 200 205Ser Cys Ser Arg Thr Ile Thr Pro Asn Thr Pro Val Asn Gly Ala Pro 210 215 220Gln Val Glu Phe Ser Thr Ala Val Asp Lys Leu Met Lys Val Ile Gln225 230 235 240Ser Lys Met Lys Asp Ala Asp Pro Glu Gln Ser Gly Asp Asp Lys Asp 245 250 255Ile Lys Ala Glu Gln Gln Ser Ser Pro Val Cys Gln Ala Arg Val Gln 260 265 270Gln Pro Ala Asp Lys His Lys Arg Lys Arg Tyr Glu Cys Gln Ile Glu 275 280 285Gly Cys Asn Lys Lys Phe Ser Gln Lys Thr His Arg Asp Thr His Val 290 295 300Arg Ser His Thr Gly Asp Arg Pro Tyr Val Cys Pro Ile Pro Gly Cys305 310 315 320Gly Gly Arg Phe Thr Gln Ala Gly Asn Leu Lys Thr His Lys Arg Arg 325 330 335His Thr Gly Glu Arg Pro Tyr Arg Cys Glu Val Cys Asp Lys Gly Phe 340 345 350Val Gln Arg Gly Asp Val Lys Ala His Met Lys Thr His Leu Gly Thr 355 360 365Lys Ala Phe Leu Cys Arg Leu Asp Asn Cys His Lys Gln Phe Thr Gln 370 375 380Arg Gly Asn Leu Lys Tyr His Gln Asn Lys Tyr His Asn Glu Thr Ile385 390 395 400Lys Ala Leu Ala Ala Arg Phe Asp Ala Ile Glu Asp Trp Ser Thr Val 405 410 415Leu Lys Glu Asp Met Glu Ile Phe Lys Asp Phe Ala Glu Val His Lys 420 425 430Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys His Arg Lys Val Lys 435 440 445Ser Val Pro Leu Ser Ser Pro Thr Ser Pro Thr Gly His Ser Pro Leu 450 455 460Pro Asn Ile Met Ala Ser Gln Tyr Pro Leu Pro Ser Ala Pro Gly Val465 470 475 480Ser Gln Leu Leu His Thr Pro His Pro Leu His Pro Pro Leu His His 485 490 495Gln Gly Pro Ser His Ser Ala Met Tyr Gly Met Pro Arg Ser Ser Leu 500 505 510His

Ser His Tyr Glu Thr Tyr Asp His His Glu Val Asp Thr Val Ala 515 520 525Ser Ser Arg Ala Ser Val Ala Glu Pro Ile Tyr His His Glu Glu His 530 535 540Pro Arg Glu Leu Ala Phe Gly Asp Arg Met Tyr545 550 55594421PRTArtificial Sequencesynthesized 94Met Arg Asn Gln Leu Pro Ala Gln Gln Gln Ser Asn Tyr Tyr Thr Asn1 5 10 15Ser Gln Pro Ala Gln Leu Pro Tyr Gln Gln Gln Gln Gln Gln Gln Gln 20 25 30Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 35 40 45Arg Gln Gln Thr Ser Lys Pro Arg Arg Asn Ser Asn Asn Arg Asp Ala 50 55 60Ile Ser Asp Gln Ser Leu Lys Ser Pro Ile Glu Ser Ser Ser Asn Glu65 70 75 80Gly Asn Leu Val Pro Ala Gln Gln Tyr Val Lys Ser Glu Asp Gly Arg 85 90 95Pro Leu Leu Gly Ala Thr Lys Ile Asp Gln Leu Met Leu Val Ile Gln 100 105 110Ala Arg Asp Lys Gly Ile Thr Ser Pro Ile Gln Gln Ala Pro Asp Gly 115 120 125Ser Ile Leu Ala Ala Pro Asp Tyr Ser Leu Ser Arg Asp Lys Ser Glu 130 135 140Leu Asp Asn Gly Val Leu Pro Arg Pro Ile Ser Leu Val Gly Gly Val145 150 155 160Asp Lys Pro Ser Lys Ala Lys Ile Lys Glu Asp Glu Gly Ser Asp Asp 165 170 175Glu Glu Ser Lys Gly Lys Arg Arg Lys His Lys Asn Gln Gln Cys Pro 180 185 190Tyr Cys Phe Lys Tyr Phe Thr Gln Ser Thr His Leu Glu Val His Ile 195 200 205Arg Ser His Ile Gly Tyr Lys Pro Phe Glu Cys Asn Tyr Cys His Lys 210 215 220Lys Phe Thr Gln Gly Gly Asn Leu Arg Thr His Leu Arg Leu His Thr225 230 235 240Gly Glu Lys Pro Phe Thr Cys Asp Ile Cys Asn Arg Gln Phe Asn Arg 245 250 255Lys Gly Asn Leu Gly Ala His Lys Leu Thr His Glu Asn Leu Lys Pro 260 265 270Tyr Glu Cys Lys Leu Asp Gly Cys Asp Lys Ser Phe Thr Gln Leu Gly 275 280 285Asn Leu Lys Ser His Gln Asn Arg Phe His Leu Ser Thr Leu Asn His 290 295 300Leu Thr Gln Lys Leu Ala Glu Leu Ser Gly Leu Ser Ile Glu Asn Leu305 310 315 320Pro Pro Asp Glu Lys Asp Leu Leu Met Tyr Phe Lys Asp Leu Tyr Lys 325 330 335Asn Ser Asn Lys Gly Ile Arg Gly Arg Gly Lys Ala Lys Leu Ser Lys 340 345 350Asp Asp Thr Gly Gly Ala Thr Ser Ser Ser Pro Asp Asn Ser Gln Phe 355 360 365Asn Leu Gln Ser Gln Ser Pro Gln Leu Gln Leu Gln Asn Leu Gln Ala 370 375 380Leu Pro Arg Gln Gln Asp Gln Gln Gln Gly Ser Pro Glu Tyr Ser Gln385 390 395 400Ser Gln His Ser Leu Asp Phe Met Asn Pro His Leu Ala Gly Ser Ile 405 410 415Asn Gly Tyr Gln Gly 42095444PRTArtificial Sequencesynthesized 95Met Glu Ile Pro Thr Ile Leu Asn Arg Lys Ala Ser Ala Ala Val Ala1 5 10 15Ala Asp Pro Arg Phe Gln Ala Gln Leu Ala Gln Ala Val His Met His 20 25 30Thr Gln Glu Met Ser Glu Gln Ala Thr Ser Gln Pro Gly Asp His Thr 35 40 45Val Met Gly Tyr Pro Pro Asn Ala Gln Pro Leu His Gln Thr Gln Gln 50 55 60Met Ala Pro Gln Leu Trp Pro Thr His Pro Asn Gly Ala Pro Val Met65 70 75 80Pro Pro Asn Gly Tyr Val His Thr Gly Phe Pro Ala Val Pro Pro Gln 85 90 95Gln Ser His Thr Pro Pro Val Gln Gln Gln Gln Gln Gln Gln Gln Ser 100 105 110Arg Pro Glu Pro Ala Pro Arg Val Phe His Cys Ser Thr Cys Gln Lys 115 120 125Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser 130 135 140Gly Ile Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe145 150 155 160Ile Gln Arg Ser Ala Leu Thr Val His Ala Arg Val His Thr Gly Glu 165 170 175Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser 180 185 190Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys 195 200 205Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu 210 215 220Thr Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala225 230 235 240Gln Thr Glu Ala Ser Leu Arg Gln Asn Arg Glu Arg Ser Ala Arg Ala 245 250 255Ser Glu Gly Ile Tyr Ser Glu Thr Gly Ser Gly His Ser Thr Pro Ser 260 265 270Pro Gly Gln Gln Ala Ser Met Gly Met Gly Ser Glu Leu Pro Pro Leu 275 280 285Asn Ile Ile Arg Ser Thr Gly Glu Tyr Tyr Ile Pro Asn Gly Gly Ile 290 295 300Pro Ala His Val Arg Gly Asp Phe Gln Gln Gly Ser Pro Arg Ala Ser305 310 315 320Pro Ala Ala Thr Ser Pro Ser Leu Ser Ser Tyr Ser Ser His Pro Arg 325 330 335Pro Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro Leu 340 345 350Glu Pro Pro Ala Asn Asn Asp His Arg Pro Gly Ser Val Thr Gly Ser 355 360 365Pro His Met Thr Ser Met Gly Trp Ala Ser Pro Ser His Gly Ser Met 370 375 380Pro Ser Pro Gly Ser Pro His Asp Phe Gly Tyr Pro Glu Ser Asn Val385 390 395 400Ala Ala Tyr Ala Ser Ala Met Pro Pro His Met Tyr Phe Pro Asn Ser 405 410 415Thr Ile Arg Arg Pro Gly Ser Thr Glu Pro Glu Asn Tyr Glu Met Lys 420 425 430Pro Arg Ile Gly Pro Asp Gly Trp Ser Thr Pro Met 435 44096344PRTArtificial Sequencesynthesized 96Met Pro Arg Thr Arg Ser Phe Pro Cys Ser Trp Val Ser Cys Lys Lys1 5 10 15Val Phe Asn Arg Lys Ser Asp Leu Cys Arg His Tyr Arg Ile His Thr 20 25 30Asn Glu Arg Pro Tyr Arg Cys Asn Phe Pro Asn Cys Thr Lys Ser Phe 35 40 45Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Thr His Thr Gly Glu 50 55 60Lys Pro His Val Cys Asn Phe Ala Asn Cys Ser Lys Ala Phe Ser Asp65 70 75 80Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Arg Arg Pro 85 90 95Tyr Lys Cys Leu Glu Pro Thr Cys Asp Arg Ser Phe Cys Arg Lys Thr 100 105 110Thr Leu Thr Lys His Gln Ser Arg Ser His Gln Pro Glu Ala Val Ser 115 120 125Pro Ser Ala Gln Ser Cys Glu Ser Glu Leu Tyr Ser Gln Gln Ala Gln 130 135 140His Ser Ile Ser Met Met Ser Gln Ser Pro Gln Val Pro Gln His Gln145 150 155 160Leu Gln Ser Gln Gln Pro Gln Pro Gln Asp Gln Gln Leu Gln Ser Gln 165 170 175Pro Gln His Leu Gln Ser Gln Pro Arg Pro Gln Gln His Ser Pro Tyr 180 185 190Gln Gln Gln His Ser Pro Ile Ile Ala Val Pro Val Ala Asp Tyr Phe 195 200 205His Ala Gln Ala Gln Pro Thr Thr Val His Ser Ile Pro Ile Ser Ala 210 215 220Glu Gln Pro Ile Leu Pro Pro Gln Val His Tyr Val Thr Thr Gly Met225 230 235 240Ile Ser Ser Gln Ile Pro Arg Tyr Asp Ile Pro Ile Thr Thr Ser Ala 245 250 255Pro Val Ser Thr Pro Thr Ser Met Asp His Leu Ala Tyr Asn His Pro 260 265 270Ile Ser Val Ser Met Pro Gln Gln Gln Arg Ile Gln Ala Pro Gln Pro 275 280 285Val Pro Ile Pro His Gln Ala Asp Gly Gly Phe Gln Val Leu Pro Val 290 295 300Val Ala Gly Gly Ala Gly Gly Gln Tyr Met Lys Glu Phe Asp Gln Met305 310 315 320Lys His Gly Gln Gln Arg Phe Phe Gly Ser Ala Tyr Pro Asp Gln Met 325 330 335Asn Trp Glu Phe Leu Gly Leu Ser 34097507PRTArtificial Sequencesynthesized 97Met Ala Leu Thr Ala Gln Pro Ser Ala Pro Ala Gly Trp Glu Arg Trp1 5 10 15Pro Gln His His Pro Ser Asn Asp Tyr Val Met Met Asp Ala Asp Val 20 25 30Met Pro Tyr Asn Ala Arg Pro Met Thr Thr Ala Pro Met Gln Gln Arg 35 40 45Pro Ser Leu Val Pro His Tyr Met Pro Thr Thr Ser Met Ser Thr Ala 50 55 60Ser Ile Asn Ser Ile Ser Ala Pro Ala His Tyr Gln Ser Pro Val Pro65 70 75 80Tyr Gly Gly Gly Tyr Pro Ala Tyr Pro Leu Pro Thr Pro Thr Thr Met 85 90 95Asn Ser Ser Tyr His Lys His Gln Gln Tyr Gln Glu Arg Pro Ser Leu 100 105 110His Met Ile Thr Pro Glu Phe Glu Asp Thr Arg Gly Pro His His Ile 115 120 125Arg Asn Ala Arg Arg Tyr Ser Glu Glu Ser Arg Ser Pro Ser Glu Arg 130 135 140Ser Asp Ser Gln Gly Ser Thr Thr Glu Thr Thr Ile Ser Asn His Ser145 150 155 160Ser Cys Ser Arg Thr Ile Thr Pro Asn Thr Pro Val Asn Gly Ala Pro 165 170 175Gln Val Glu Phe Ser Thr Ala Val Asp Lys Leu Met Lys Val Ile Gln 180 185 190Ser Lys Met Lys Asp Ala Asp Pro Glu Gln Ser Gly Asp Asp Lys Asp 195 200 205Ile Lys Ala Glu Gln Gln Ser Ser Pro Val Cys Gln Ala Arg Val Gln 210 215 220Gln Pro Ala Asp Lys His Lys Arg Lys Arg Tyr Glu Cys Gln Ile Glu225 230 235 240Gly Cys Asn Lys Lys Phe Ser Gln Lys Thr His Arg Asp Thr His Val 245 250 255Arg Ser His Thr Gly Asp Arg Pro Tyr Val Cys Pro Ile Pro Gly Cys 260 265 270Gly Gly Arg Phe Thr Gln Ala Gly Asn Leu Lys Thr His Lys Arg Arg 275 280 285His Thr Gly Glu Arg Pro Tyr Arg Cys Glu Val Cys Asp Lys Gly Phe 290 295 300Val Gln Arg Gly Asp Val Lys Ala His Met Lys Thr His Leu Gly Thr305 310 315 320Lys Ala Phe Leu Cys Arg Leu Asp Asn Cys His Lys Gln Phe Thr Gln 325 330 335Arg Gly Asn Leu Lys Tyr His Gln Asn Lys Tyr His Asn Glu Thr Ile 340 345 350Lys Ala Leu Ala Ala Arg Phe Asp Ala Ile Glu Asp Trp Ser Thr Val 355 360 365Leu Lys Glu Asp Met Glu Ile Phe Lys Asp Phe Ala Glu Val His Lys 370 375 380Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys His Arg Lys Val Lys385 390 395 400Ser Val Pro Leu Ser Ser Pro Thr Ser Pro Thr Gly His Ser Pro Leu 405 410 415Pro Asn Ile Met Ala Ser Gln Tyr Pro Leu Pro Ser Ala Pro Gly Val 420 425 430Ser Gln Leu Leu His Thr Pro His Pro Leu His Pro Pro Leu His His 435 440 445Gln Gly Pro Ser His Ser Ala Met Tyr Gly Met Pro Arg Ser Ser Leu 450 455 460His Ser His Tyr Glu Thr Tyr Asp His His Glu Val Asp Thr Val Ala465 470 475 480Ser Ser Arg Gly Ser Val Ala Glu Pro Ile Tyr His His Glu Glu His 485 490 495Pro Arg Glu Leu Ala Phe Gly Asp Arg Met Tyr 500 50598308PRTArtificial Sequencesynthesized 98Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Ile Val1 5 10 15Ala Ala Asp Val His Gln Leu Gln Gln His Leu Ala Gln Ala Thr Ala 20 25 30Gln Ser Gln Thr Asp Asp Ala Val Lys Ser Arg Ser Pro Ser Glu Leu 35 40 45Gly Ala Ser Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His 50 55 60His His His His His His His Gln Pro Thr Ser Ser Phe Pro Ser Ser65 70 75 80Thr Gln Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val Gln 85 90 95Ala Gln Ala Asn His Ala Ser Thr Ser Pro Gly Tyr Ala His Ser Ala 100 105 110His Gly Ser Asp Tyr Gly Arg Ser Thr Thr Ser Met Arg Pro Thr Gly 115 120 125Leu Pro Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly Phe 130 135 140Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile145 150 155 160Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln 165 170 175Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 180 185 190His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 195 200 205Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 210 215 220Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg225 230 235 240His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr 245 250 255Glu Ala Asn Leu Arg His Ser Lys Asp Arg Ser Thr Thr Ser Arg Pro 260 265 270Ser Glu Tyr Ser Glu Pro Gly Ser Ala His Ser Thr Pro Ser Pro Ala 275 280 285Gln Arg Pro Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn Leu 290 295 300Ser Ser Arg Pro30599430PRTArtificial Sequencesynthesized 99Met Val Ala Ala Glu Phe Asp His Gln Gln Phe Ile Gln Asn Pro His1 5 10 15Leu Asp Thr Ser Ser Pro Lys Met Lys Pro Glu Pro Gly Val Ser Glu 20 25 30Ala Gly Asp Gln Pro Val Leu Ala Tyr Pro Pro His Ala Pro Leu Gly 35 40 45Gln Val Pro Asn Met His Pro Asp Met Arg Tyr Gln Pro Gln Thr His 50 55 60Pro Asn Pro Ala Leu Pro Leu Leu Gln Asn Pro Tyr Met Pro Gly Gly65 70 75 80Tyr Thr Ser Ala Pro Pro Met Pro Asn Gly Gly Ala Pro Gln Gly Arg 85 90 95Thr Asp Pro Pro Pro Lys Thr Phe His Cys Gly Thr Cys Ser Lys Gly 100 105 110Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly 115 120 125Ile Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile 130 135 140Gln Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu Lys145 150 155 160Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 165 170 175Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 180 185 190Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr 195 200 205Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu 210 215 220Thr Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Val Arg Ala Pro Gly225 230 235 240Glu Gly Met Tyr Ser Glu His Gly Ser Val His Ser Thr Pro Ser Pro 245 250 255Ala His His Pro Ala Leu Ser Pro Ala Gly Glu Leu Pro Pro Leu Asn 260 265 270Met Pro Arg Ser Ser Gly Glu Tyr Tyr Ser Met Gly Asn Gly Ser Ile 275 280 285Pro Pro His Val Arg Gly Asp Phe Pro Gln Ala Ser Pro Arg Ala Ser 290 295 300Pro Thr Ala Thr Ser Pro Ser Leu Ser Ser Phe Gly Ser Ala Pro His305 310 315 320Thr Arg Pro Ser Met Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln 325 330 335Pro Leu Glu Pro Pro Ala Asn Asn Asp His Arg Pro Asn Ser Val Ser 340 345 350Gly Ser Pro His Met Thr Ser Leu Gly Trp Ala Ser Pro Ser His Gly 355 360 365Ser Ile Pro Ser Pro Gly Ser Ala Thr Asp Phe Gly Tyr Ser Asp Pro 370 375

380Asn Gly Pro Ala Tyr Pro Asn Ser Met Pro Pro His Met Tyr Phe Pro385 390 395 400Asn Ser Thr Ile Arg Arg Pro Thr Ser Thr Glu Pro Glu Asn Tyr Glu 405 410 415Met Lys Pro Lys Ile Gly Glu Ser Ala Trp Ser Thr Pro Val 420 425 430100540PRTArtificial Sequencesynthesized 100Met Cys Arg Ala Arg Leu Leu Ser Arg Val Pro Pro Gly Trp Arg Glu1 5 10 15Val Pro Ser Pro Phe Pro Ile Leu Pro Pro Ile Asp Arg Tyr Ser Thr 20 25 30Asp Arg Met Ala Leu Thr Ala Gln Pro Ser Ala Pro Ala Gly Trp Glu 35 40 45Arg Trp Pro Gln His His Pro Asn Asn Asp Tyr Val Met Met Asp Ala 50 55 60Asp Val Met Pro Tyr Asn Ala Arg Pro Met Thr Thr Ala Pro Met Gln65 70 75 80Gln Arg Pro Ser Leu Val Pro His Tyr Met Pro Thr Thr Ser Met Ser 85 90 95Thr Ala Ser Ile Asn Ser Ile Ser Ala Pro Ala His Tyr Gln Ser Pro 100 105 110Met Ser Tyr Gly Gly Gly Tyr Pro Ala Tyr Pro Leu Pro Thr Pro Thr 115 120 125Thr Met Asn Ser Pro Tyr Lys His Gln Gln Tyr Gln Glu Arg Pro Thr 130 135 140Leu His Met Ile Thr Pro Glu Ile Glu Asp Thr Arg Gly Pro His His145 150 155 160Ile Arg Asn Ala Arg Arg Tyr Ser Ala Glu Ser Arg Ser Pro Ser Glu 165 170 175Arg Ser Asp Ser Gln Val Ser Thr Thr Glu Ile Thr Ile Ser Asn His 180 185 190Ser Ser Cys Ser Arg Thr Ile Thr Pro Asn Thr Pro Val Asn Gly Ala 195 200 205Pro Gln Val Glu Phe Ser Thr Ala Val Asp Lys Leu Met Lys Val Ile 210 215 220Gln Ser Lys Met Lys Asp Ala Asp Pro Glu Gln Ser Gly Asp Asp Arg225 230 235 240Asp Ile Lys Ala Glu Gln Gln Ser Ser Pro Val Cys Gln Ala Arg Val 245 250 255Gln Gln Pro Ala Asp Lys Leu Lys Arg Lys Arg Tyr Glu Cys Gln Ile 260 265 270Glu Gly Cys Asn Lys Lys Phe Ser Gln Lys Thr His Arg Asp Thr His 275 280 285Val Arg Ser His Thr Gly Asp Arg Pro Tyr Val Cys Pro Ile Pro Gly 290 295 300Cys Gly Gly Arg Phe Thr Gln Ala Gly Asn Leu Lys Thr His Lys Arg305 310 315 320Arg His Thr Gly Glu Arg Pro Tyr Arg Cys Glu Val Cys Asp Lys Gly 325 330 335Phe Val Gln Arg Gly Asp Val Lys Ala His Met Lys Thr His Leu Gly 340 345 350Thr Lys Ala Phe Leu Cys Lys Leu Asp Asn Cys His Lys Gln Phe Thr 355 360 365Gln Arg Gly Asn Leu Lys Tyr His Gln Asn Lys Tyr His Asn Glu Thr 370 375 380Ile Lys Ala Leu Ala Ala Arg Phe Asp Ala Ile Glu Asp Trp Ser Thr385 390 395 400Val Leu Lys Glu Asp Met Glu Ile Phe Lys Asp Phe Ala Glu Val His 405 410 415Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys His Arg Lys Val 420 425 430Lys Ser Val Pro Leu Ser Ser Pro Thr Ser Pro Thr Gly His Ser Pro 435 440 445Leu Pro Asn Ile Met Ala Ser Gln Tyr Pro Leu Pro Ser Ala Pro Gly 450 455 460Val Ser Gln Leu Leu His Thr Pro His Pro Leu His Pro Pro Leu His465 470 475 480His Gln Gly Pro Ser His Ser Ala Met Tyr Gly Met Pro Arg Gln Ser 485 490 495Leu His Ser His Tyr Glu Thr Tyr Asp His His Glu Val Asp Thr Val 500 505 510Pro Ser Ser Arg Gly Pro Val Ala Glu Pro Ile Tyr His His Glu Glu 515 520 525His Pro Arg Glu Leu Ala Ser Gly Asp Arg Met Tyr 530 535 540101432PRTArtificial Sequencesynthesized 101Met Glu Ile His Glu Leu Ile Ile Asp Glu Arg His Ala Pro Lys Gln1 5 10 15Phe Pro Cys Asp Trp Pro Asp Cys Asn Lys Lys Phe Asn Arg Lys Ser 20 25 30Asp Leu Gln Arg His His Arg Ile His Thr Asn Thr Arg Pro Tyr Ala 35 40 45Cys Thr Phe Ala Gly Cys Lys Lys Ser Phe Ile Gln Arg Ser Ala Leu 50 55 60Thr Val His Ile Arg Thr His Thr Gly Glu Lys Pro His Gln Cys Glu65 70 75 80Phe Ile Gly Cys Gly Lys Cys Phe Ser Asp Ser Ser Ser Leu Ala Arg 85 90 95His Arg Arg Ile His Thr Gly Arg Arg Pro Tyr Leu Cys Gly Val Asn 100 105 110Arg Cys Gly Lys Ser Phe Cys Arg Lys Thr Thr Leu Ile Lys His Ala 115 120 125Arg Arg Ala His Gly Ile Gly Gln Asn Leu Asp Val Ser Asp Asp Asp 130 135 140Ser Glu Asn Asp Asp Ser Thr Thr Thr Glu Arg Ser His Pro Lys Pro145 150 155 160Val Ser Gln Ala Arg Ala Glu Val Ile Arg Asn His Gly Pro Glu Ser 165 170 175Val Leu Gln Asn Gln Gly Arg His Leu Ser Leu Phe Arg Pro Glu Leu 180 185 190Ser Leu Pro Ser Ser Pro Arg Ser Asn Ser Asn Thr Ile Gly Phe Gly 195 200 205Asp Thr Tyr Gly Ser Ala Ser Ala Val Tyr His Pro Gln Asn Leu Val 210 215 220Ser Asp His Pro Met Thr Pro Thr Ser Pro Tyr Cys Phe Gln Glu Thr225 230 235 240Pro Pro His Ala His Val Pro Pro Phe Pro Asn Leu Pro Arg Thr Cys 245 250 255Ala Glu Asp Phe Ile Pro Thr Gly Thr Gly Leu Pro Gln His Pro Gln 260 265 270Asn Pro Gln Tyr Asn Pro Asn Leu Arg Ile Ile Cys Ser Ser Ser Pro 275 280 285Thr Gln Gln Ala Leu Ala Ala Gly His Cys Val Gly Ser Pro Gly Glu 290 295 300Leu Ser Asn Cys Ser Thr Ala Thr Ser Gly Ala Ser Val Asp Tyr Phe305 310 315 320Tyr Arg Asn Pro Ser Thr Val Asp Gly Val Gly Asn Val Thr Leu Phe 325 330 335Met Gln Gln Ser Ala Ala Ser Asp His Ile Ser His Gln Val Gln Asp 340 345 350Gln Gly Ile Ala Glu Met Pro Ile Ala Val Met Ser Gln Gln Gln His 355 360 365Gln His His Pro Gln Gln Pro Gly Ala Ala Ile Trp Tyr Gly Tyr Ser 370 375 380Gln Phe Asp Gln Pro Gln Phe His Ser Gly Ser Glu Gln Arg Leu Phe385 390 395 400Tyr Glu Asn Gly Asn Met Glu Asn Ile Thr Pro Val Lys Ala Thr Thr 405 410 415Ser Glu Val Val Leu His Pro Leu Leu Thr Pro Arg Ala Ser Leu Cys 420 425 430102457PRTArtificial Sequencesynthesized 102Met Glu Thr Ala Glu Pro Val Ser Tyr Glu Phe Pro Gly His Ala Val1 5 10 15Gly Ala Val Ala Ser Arg Arg Met Leu Gly Ser Asn Ile Asn His Asn 20 25 30Phe Ser Phe Tyr Thr Asn Pro Thr Ala Ser Phe Pro Leu Pro Tyr His 35 40 45Gln Pro Pro Ser Ala Thr Tyr Ser Phe Ser His Pro Leu Asn Thr His 50 55 60His His His Gln His His Gln Pro Gln Pro Gln His Pro Gln His His65 70 75 80Asn His His His Gln His Pro Gly Tyr Gln His Phe Phe Val Pro Asn 85 90 95His Ser Leu Asn Ala Gln Ser Ala Arg Leu Ala Ser Glu Pro Pro Leu 100 105 110Ala Gln Pro Ile Pro Asp Ile Arg Pro Ala Arg Asn Ala Val Asn Arg 115 120 125Val Ser Gly Asp Ser Val Ala Lys Val Glu Gln Arg Ala Ala Pro Gln 130 135 140Ser Ser Ser Val Ala Ala Ala Pro Gly Asn Gly Val Ser Ala His Glu145 150 155 160Lys Asn Pro Asn Ala Ser Glu Val Glu Phe Ser Thr Glu Val Asp Val 165 170 175Leu Met Lys Ala Ile Gln Ala Lys Glu Ala Ser Gln Pro Ala Ala Leu 180 185 190Gln Ser Leu Pro Pro Leu Gln Gln Leu Thr His Gly Gly Gly Asn Gly 195 200 205Phe Ala Gln Gly Tyr Met Ser Ala Val Val Asn His Arg Gly Ala Val 210 215 220Ile Ala Asp Glu Ser Gln Ser Arg Ser Ala Lys Lys Arg Lys Tyr Thr225 230 235 240Cys Thr Leu Pro His Cys Gly Lys Ser Phe Ala Gln Lys Thr His Leu 245 250 255Asp Ile His Met Arg Ala His Thr Gly Asp Lys Pro Phe Val Cys Lys 260 265 270Glu Pro Thr Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu Lys Thr 275 280 285His Gln Arg Arg His Thr Gly Glu Lys Pro Phe Thr Cys Asp Val Cys 290 295 300Gln Lys Arg Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Thr305 310 315 320His Leu Lys Thr Lys Pro Phe Thr Cys Leu Leu Glu Gly Cys Gly Lys 325 330 335Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His 340 345 350Thr Gln Thr Leu Gln Ala Leu Thr Lys Lys Phe Ser Ala Met Ile Asp 355 360 365Gly Glu His Met Ser Pro Gln Asp Arg Lys Leu Trp Glu Tyr Phe Ala 370 375 380Gly Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp385 390 395 400Arg Arg Ile Ser Pro Ser Ser Lys Thr Asn Val Ser Ala Asp Gly Ser 405 410 415Arg Arg Pro Gly Ala Asp Asp Gln Ala Arg Arg Gly Ser Tyr Glu Asp 420 425 430Ser Val Tyr Thr Gly Ala Ser Ser Ser Asp Glu Asp Asn Glu Asp Pro 435 440 445Tyr Phe Ile Glu Lys Arg Gly Asp Glu 450 455103478PRTArtificial Sequencesynthesized 103Met Glu Leu Asp Thr Ile Leu Asn Ala Arg Leu Thr Ala Ser Leu Gly1 5 10 15Thr Gly Ala Leu Phe Thr Met Gln His Ala Met Gln Gln Gln His Phe 20 25 30Gly Ala Pro Pro Ser Tyr Leu Asn Gly Gly His Ile Lys Ser Glu Asn 35 40 45Gly Ser Glu Arg Gly Val Ser Pro His Pro Ser Asp Ser Ser Arg Tyr 50 55 60Ser Ser Gln Gln Pro Gln Gln Ser Leu Pro Ser Tyr Pro Ser Ile Pro65 70 75 80Gln Gln His Met Asn Gly Leu Arg Tyr Pro Ser Pro Ser Gln Met Gln 85 90 95Ala Pro Met Pro Met Leu Asn Asn Ser Asn Tyr Ile Pro Asn Pro Pro 100 105 110Asp His Ala Tyr Ala Gln Gln Gln Gln Met Pro Asp Thr Gln Val Gln 115 120 125His Gln His Asn Gly Gly Arg Pro Ala Ser Asp Thr Gly Pro Pro Lys 130 135 140Ala Phe Ala Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp145 150 155 160Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys 165 170 175Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr 180 185 190Val His Gln Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg 195 200 205Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg 210 215 220Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln225 230 235 240Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His 245 250 255Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala 260 265 270Ser Arg Ala Ser Ala Ser Ser Arg Thr Gly Arg Ser Asp Gly Gly Asp 275 280 285Tyr Ser Glu Thr Ala Ser Pro Leu Gly Thr Pro Ser Pro Asn Asp Arg 290 295 300Thr Leu Ser Leu Ser Pro Ala Asn Gly Met Pro Ala Gly Gly Met Pro305 310 315 320Gly Leu His Arg Gln Gly Ser Asp Tyr Ala Tyr Met Gly Gly Met Asn 325 330 335Val Pro Pro His Met Arg His Glu Met Pro Gln Pro Ser Pro Arg Ala 340 345 350Ser Pro Ala Leu Thr Ala Gln Ser Tyr Ala Ser Asn Val Ser Gly Thr 355 360 365Arg Pro Ala Ile Thr Ser His Pro Ser Ala Tyr Gly Pro Pro Pro Ile 370 375 380Leu Glu Pro Pro Ala Ser Ala Asn His Asn Gln Ser Gly Thr Asn Ser385 390 395 400Ala Asn Ala Ser Pro His Met Ser Ala Met Gly Trp Gln Ser Pro Gly 405 410 415Gln Gln Ala Leu Pro Ser Pro Gly Ala Ala Asp Asn Gly Tyr Val Tyr 420 425 430Pro Glu Pro Gln Tyr Gln Ala Gln Asn Gly Met Tyr Tyr Gln His Asn 435 440 445Asn Ile Arg Arg Pro Asn Ser Thr Glu Pro Asp His Tyr Asn Pro Asn 450 455 460Gln Gln Arg Met Gly Asn Glu Met Trp Ala Pro Ala Val Gln465 470 475104369PRTArtificial Sequencesynthesized 104Met Asn Arg Ala Asp Ile Ala Met His Thr Tyr Ala His His Ser His1 5 10 15Val Ala His Gly Ala Ile Pro Ala Ser Asn Phe Glu Leu Thr Ser Ser 20 25 30Phe Phe Ala Asn Pro Ala Phe Thr Tyr Pro Ala Gln Tyr Asn Ser Ile 35 40 45Asp Leu Gly Tyr Asp Leu Gly Leu Gly Tyr Gly Gly Cys Asn Leu Gly 50 55 60His Gly Ala Asn Ala Ser Pro Gln Gln Ile Phe Gly Gln His Ser Ala65 70 75 80Ser Tyr Ser Glu Gln Gly Leu His Val Pro Ala Ser Gln Gln Pro Ala 85 90 95Pro Gly Glu Pro Ala Gln Arg Ser Pro Ala Ile Lys Val Glu Ala Ala 100 105 110Ser Gln Asp Ala Asp Asn Val Glu Phe Gln Pro Tyr Ser Val Pro Thr 115 120 125Ser Thr Leu Pro Thr Ser Ala Thr Asp Ala Asp Val Gly Thr Asp Val 130 135 140Asp Thr Leu Met Arg Ala Ile Gln Thr Lys Ala Lys Thr Ser Ser Thr145 150 155 160Gln Ala Pro Ser Ser Ala Ala Leu Ile Asp Gln Arg Arg Ser Lys Ala 165 170 175Arg Arg Lys Tyr Pro Cys Lys Val Gln Ser Cys Ala Lys Val Phe Thr 180 185 190Gln Lys Thr His Leu Glu Ile His Met Arg Ala His Thr Gly Tyr Lys 195 200 205Pro Tyr Leu Cys Arg Glu Thr Ser Cys Gly Gln Arg Phe Ser Gln Leu 210 215 220Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly Glu Arg Pro Tyr225 230 235 240Ser Cys Asp Arg Cys Gly Arg Ser Phe Ala Gln Arg Gly Asn Val Gln 245 250 255Ala His Arg Ile Val His Glu Arg Ile Lys Pro Tyr Cys Cys Gln Leu 260 265 270Glu Gly Cys Ser Lys Arg Phe Thr Gln Leu Gly Asn Leu Lys Ser His 275 280 285Gln Asn Lys Phe His Thr Glu Thr Leu Arg Val Leu Ala Val Lys Phe 290 295 300Ala Ser Leu Arg Glu Glu Asp Ala Met Ser Glu Ala Asp Arg Glu Leu305 310 315 320Trp Glu Tyr Phe Ser Thr Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys 325 330 335Gly Arg Gly Lys Asp Arg Arg Ile Ala Ala Val Asp Arg Asn Gly Asp 340 345 350Gly Leu Lys Gln Glu Thr Gln Asp Cys Glu Ser Ser Ser Ser Val Ser 355 360 365Pro105437PRTArtificial Sequencesynthesized 105Met Ser Ser Ala Ser Pro Glu Val Met Asp Ile Thr Asn Met Leu Asn1 5 10 15Asn Lys Gly Gly Ala Met Ala His Gly Leu Gly Gly Ser Met Pro Asp 20 25 30His His Gln Gln His His His Leu Gly Leu Val Lys His Glu Ser Ala 35 40 45Leu Asp Arg Ser Gly Ser Pro His Met Ser Glu His Ser Ser Tyr Ser 50 55 60Ala His Ser Met Pro Arg Ala Tyr Pro Ser Pro Thr Ala Met Gln Thr65 70 75 80Pro Met Gln Met Gln Asn His Met His Asn Ala Met Gln Met Gly Gly 85 90 95Phe Thr Asp Met Ser Gly Met Gly Ser Val Pro Ser Met Ala Met His 100 105 110His Met Pro Gln Gln Pro

Gln Gln Gln Gln Ala Pro Thr Ala Pro Val 115 120 125Lys Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser 130 135 140Asp Leu Ala Arg His Glu Arg Ile His Thr Gly Val Arg Pro His Val145 150 155 160Cys Asp Tyr Pro Lys Cys His Lys Gly Phe Ile Gln Arg Ser Ala Leu 165 170 175Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His Arg Cys Glu 180 185 190Thr Cys Ala Lys Leu Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg 195 200 205Arg Thr His Ser Gly Thr Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys 210 215 220Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn Gln225 230 235 240His Thr Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu 245 250 255Ala Ala Ser Arg Val Lys Asn Gly Ser Gln Ala Arg Ser Asp Gly Asp 260 265 270His Met Ser Asn Gln Gly Ser Pro Leu Thr Thr Pro Ser Pro Asn His 275 280 285His Ala Met Met Ser Pro Ala Met Asp Leu Ser Gly Ala Asn Gly Leu 290 295 300Gly Arg His Gln Ala Asp Phe Thr Gln Tyr Met Thr Gln Gly Gly Thr305 310 315 320Leu Pro Pro His Leu Arg Val Gly Ser Pro Thr Ser Thr Asn Ser Ala 325 330 335Ala Ser Tyr Asn Ser Gly Ile Arg Pro Thr Ser His Pro Thr Gly Tyr 340 345 350Gly Pro Pro Pro Thr Leu Glu Pro Ser Leu Glu Gln His Thr Gly Ala 355 360 365Thr Gly Ser Ala Val Gly Ser Pro His Met Ala Ser Gln Leu Gly Trp 370 375 380Gln Ser Pro His Ser Ser Ser Pro Ser Gln His Gly Gly Ser Tyr Val385 390 395 400Tyr Pro Asp Pro Asp Gly Tyr Pro Pro Asn Pro Ser Met Ser Gln Met 405 410 415Tyr Tyr Gly Ala Pro Gln Gln Met Arg Arg Pro Gln Ser Ala Glu Pro 420 425 430Gly Met Val His Met 435106453PRTArtificial Sequencesynthesized 106Met Gln Gln Gln His Phe Gly Ala Pro Pro Ser Tyr Leu Asn Gly Gly1 5 10 15His Ile Lys Ser Glu Asn Gly Ser Glu Arg Gly Val Ser Pro His Pro 20 25 30Ser Asp Ser Ser Arg Tyr Ser Ser Gln Gln Pro Gln Gln Gln Leu Pro 35 40 45Ser Tyr Pro Ser Ile Pro Gln Gln His Met Asn Gly Leu Arg Tyr Pro 50 55 60Ser Pro Ser Gln Met Gln Ala Pro Met Pro Met Leu Asn Asn Ser Asn65 70 75 80Tyr Ile Pro Asn Pro Pro Asp His Ala Tyr Ala Gln Gln Gln Gln Met 85 90 95Pro Asp Asn Gln Val Gln His Gln His Asn Gly Gly Arg Pro Ala Ser 100 105 110Asp Thr Gly Pro Pro Lys Ala Phe Ala Cys Ser Thr Cys Gly Lys Gly 115 120 125Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly 130 135 140Ile Arg Pro His Val Cys Asp Tyr Pro Asn Cys Gly Lys Gln Phe Ile145 150 155 160Gln Arg Ser Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys 165 170 175Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser 180 185 190Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys 195 200 205Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr 210 215 220Arg His Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala225 230 235 240Thr Ala Ala Ala Leu Ala Ser Arg Ala Ser Ala Ser Ser Arg Thr Gly 245 250 255Arg Ser Asp Gly Gly Asp Tyr Ser Glu Thr Ala Ser Pro Leu Gly Thr 260 265 270Pro Ser Pro Asn Asp Arg Thr Leu Ser Leu Ser Pro Ala Asn Gly Met 275 280 285Pro Ala Gly Gly Met Pro Gly Leu His Arg Gln Gly Ser Asp Tyr Ala 290 295 300Tyr Met Gly Gly Ile Asn Val Pro Pro His Met Arg His Glu Met Pro305 310 315 320Gln Pro Ser Pro Arg Ala Ser Pro Ala Leu Thr Ala Gln Ser Tyr Ala 325 330 335Ser Asn Val Ser Gly Ser Arg Pro Ala Ile Thr Ser His Pro Ser Ala 340 345 350Tyr Gly Pro Pro Pro Ile Leu Glu Pro Pro Ala Ser Ala Asn His Asn 355 360 365Gln Ser Gly Gly Thr Asn Ser Ala Asn Gly Ser Pro His Met Ser Ala 370 375 380Met Gly Trp Gln Ser Pro Gly Gln Gln Ala Leu Pro Ser Pro Gly Ala385 390 395 400Gly Asp Asn Gly Tyr Val Tyr Pro Glu Pro Gln Tyr Gln Ala Gln Asn 405 410 415Gly Met Tyr Tyr Gln His Asn Asn Ile Arg Arg Pro Asn Ser Thr Glu 420 425 430Pro Asp His Tyr Asn Pro Asn Gln Gln Arg Met Gly Asn Glu Met Trp 435 440 445Ala Pro Ala Val Gln 450107518PRTArtificial Sequencesynthesized 107Met Ala Leu Gly Phe Leu Pro Pro Asn Pro Glu Thr Trp Gly Arg Trp1 5 10 15Pro Gln His Gln His Thr Gly Ala Asp Cys Gly Met Met Asp Ala Gly 20 25 30Met Val Pro Tyr Asp Cys Arg Pro Gly Ala Thr Ala Ser Ile Pro Arg 35 40 45Pro Glu Leu Ala Gln His Phe Leu Pro Gly Pro Phe Asn Pro Ala Ser 50 55 60Val Pro Ser Pro Ala Ser Pro Gln Tyr His Ala Pro Val Ser Tyr Gly65 70 75 80Gly Tyr Ser Pro Tyr Asn Pro Ser Ser Met Leu Glu Ala Pro Phe Lys 85 90 95Pro His Gly Leu Gln Gly Arg Met Asp Gly Leu Pro Leu Val Gly Arg 100 105 110Ser Ser Ser Pro Ser Val Lys Ser Glu Ala Lys Ser Thr Lys Ser Glu 115 120 125Ser Pro Ser Pro Ser Thr Lys Val Val Ile Pro Asn Val Arg Val Gln 130 135 140Gly Ala Pro Val His Glu Phe Asn Thr Ala Ile Asp Arg Leu Ala Lys145 150 155 160Val Ile Glu Thr Lys Arg Glu Ile Leu Ser Ser Pro Asn Pro Ala Lys 165 170 175Glu Glu Pro Gly Gln Pro Asn Glu Gly Val Glu Gly Gly Glu Met Gln 180 185 190Gln Ala Arg Gly Lys Ala Lys Arg Lys Arg Phe Cys Cys Asp Ile Pro 195 200 205Gly Cys Ser Lys Met Phe Ala Gln Lys Asn Asn Leu Asp Thr His Arg 210 215 220Arg Ala His Thr Gly Glu Ser Pro Tyr Val Cys Pro Ile Cys Leu His225 230 235 240Arg Phe Thr Gln Ser Val Asn Leu Lys Ser His Ile Arg Arg His Leu 245 250 255Gly Glu Arg Pro Tyr Lys Cys Pro Gln Cys Pro Lys Ala Phe Ser Gln 260 265 270Pro Ser Asn Val Lys Ala His Met Lys Thr His Glu Arg Arg Glu Leu 275 280 285Arg Ala Arg Trp Val Cys Arg Phe Gly Ser Cys Arg Lys Ser Phe Thr 290 295 300Ala Lys Gly Asn Leu Lys Ser His Gln Asn Thr Tyr His Val Glu Ala305 310 315 320Ile Glu Ala Phe His Ala Lys Leu Ala Ser Ile Glu Asp Lys Ser Met 325 330 335Ile Thr Glu Glu Asp Lys Glu Met Ala Arg Tyr Ile Thr Glu Val His 340 345 350Asn Leu Ala Asn Lys Gly Ile Lys Gly Arg Gly Lys Gly Arg Lys Val 355 360 365Lys Arg Leu Leu Pro Leu Pro Met Gln Pro Ser Ser Ala Ala Ala Ala 370 375 380Ala Thr Thr Thr Thr Thr Thr Thr Ser Leu Ser Ala Ala Thr Ala Ile385 390 395 400Val His Gly Asn Pro Tyr Ser Met Pro Pro Leu Leu Pro His Ala Pro 405 410 415Pro His His Leu Gln Ala Ala Pro Gln Pro Ser Ala Ala His His Gly 420 425 430His Gln His His His Phe Tyr Gly Leu Ser Asn Pro Ala Ala Tyr Ser 435 440 445Met Ser Arg Pro Ser Val Ser Ser Ala Met Leu Phe Gly Val Gly Leu 450 455 460Gly Ile Asn Thr Arg Asp Val Val His Gly His Gly Ala Tyr Gly Met465 470 475 480Leu Asp Ser Asp Gln Ile Ser Glu Ala Ser Ser Val His Ser Pro Pro 485 490 495Pro Val Met His His Val Tyr Asp Asp Glu His Ala Arg Glu Leu Ala 500 505 510Phe Gly Glu Arg Leu Tyr 515108414PRTArtificial Sequencesynthesized 108Met Asp Ile Thr Thr Ile Leu Asn Lys Asn Arg Ser Ala Val Ala Ala1 5 10 15Ala Ala Glu Ala Gln Leu Gln His Gln Leu Ser Gln Thr Ser His Met 20 25 30Lys Ser Arg Ser Pro Ser Glu Met Gly Ser Glu His Asp Pro Gln His 35 40 45Pro Gly Arg His Thr Glu Ser Tyr Gln Gln Val Pro Gln Pro Ile Gln 50 55 60Leu Pro Asn Ile Ser Gln Tyr His Ser Pro Ile His Ala Asn His His65 70 75 80Pro Ser Ile Leu Arg Gly Asp Tyr Ser Gln Asn Gly His Glu Thr Met 85 90 95Phe Arg Asn Val Pro Gly Thr Ser Ser Pro Thr Ser Arg Thr Asn Gly 100 105 110Glu Pro Ala Pro Lys Ser Phe His Cys Gln Thr Cys Gly Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 130 135 140Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Asp Arg Cys Gly Lys Lys Thr Phe Thr Arg Arg Thr Thr 180 185 190Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala 195 200 205Ala Glu Thr Glu Ala Asn Leu Arg Gln Gly Lys Val Val Arg Pro Gly 210 215 220Asp Gly Val Tyr Ser Glu Thr Ala Ser Thr His Gly Thr Ala Ser Pro225 230 235 240Ala Gln Arg Ser Ser Pro Ser Pro Arg His Glu Leu Pro Pro Leu His 245 250 255Ala His Arg Gln Met Gly Asp Tyr Phe Met Gly Asn Ser Ser Leu Pro 260 265 270Pro His Leu Arg Gly Asp Phe Gln Gln Ala Ser Pro Arg Ala Ser Pro 275 280 285Ser Ala Pro Ser Pro Thr Leu Ser Thr Phe Ser Thr Ser His Pro Ala 290 295 300Arg Pro Ser Leu Thr Ser His Pro Thr Gly Tyr Gly Pro Pro Gln Pro305 310 315 320Leu Glu Pro Pro Pro Asn Gly Gly Ser Arg Pro Gly Ser Val Thr Gly 325 330 335Ser Pro His Met Thr Thr Val Gly Trp Ala Ser Pro Ser Leu Asn Ser 340 345 350Ile Pro Ser Pro Gly Ser Ile Ser Ala Pro Glu Tyr Thr Tyr Pro Glu 355 360 365Pro Ser Gly Pro Pro Phe Ala Gly Gly Val Pro Ala His Met Tyr Tyr 370 375 380Pro Asn Ser Thr Ile Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr385 390 395 400Glu Leu Lys Pro Lys Met Glu Glu Asn Trp Thr Ala His Ser 405 410109553PRTArtificial Sequencesynthesized 109Met Gln Leu Pro Thr Pro Pro Gly Trp Gly Gln Trp Gln Gln Asn Glu1 5 10 15Val Glu Ser Gly Tyr Val His Ile Gly Ser Pro Met Met Gly Thr Gln 20 25 30Thr Pro Leu Gln Gln Pro Thr Leu Ser Ser Gln Tyr Pro Val Thr Leu 35 40 45Ala Pro Ser Pro Ser Leu Gln Gln Pro Ile Ser Tyr Ala Pro Tyr Thr 50 55 60His Gly Leu Pro Ser Val Ala Pro Leu Gln Met Pro Thr Val Gly Ser65 70 75 80Gln His Asn His Gln His Gln His Gln His His His Ser Gln His His 85 90 95His Gln Gln His Gln Ile Gln Phe Pro Asp His Ser Ile Gln Arg Pro 100 105 110Arg Arg Lys Leu Val Asn Thr Arg Ser Leu Arg Asp Thr Thr Ala Glu 115 120 125Ala Met Glu Ala Gly His Arg Gly Arg Thr Thr Pro Glu Arg Ala Thr 130 135 140Arg Arg Val Pro Lys Thr Ile Val Ala Asn Ala Pro Val Val Gly Ala145 150 155 160Ser His Val Gly Asn His Val Glu Phe Asn Thr Ser Val Asp Lys Leu 165 170 175Met Lys Ile Ile Gln Ser Met Pro Glu Thr Gly Thr Leu Val Glu Ser 180 185 190Ile Glu Ser Val Val Lys Pro Glu Pro Ala Val Ser Pro Ile Asp Glu 195 200 205Gln Lys Pro Ala Ser Glu Lys Leu Thr Val Arg Arg Phe Val Cys His 210 215 220Phe Arg Gly Cys Leu Lys Lys Phe Ala Gln Lys Ala Gln Leu Asp Thr225 230 235 240His Val Arg Ser His Thr Gly Glu Arg Pro Tyr Val Cys Glu Phe Pro 245 250 255Asn Cys Gly Lys Arg Phe Ser Gln Ser Gly Asn Leu His Thr His Glu 260 265 270Arg Lys His Thr Gly Glu Arg Pro Tyr Val Cys Asp Ile Cys Gly Arg 275 280 285Arg Phe Ala Gln Gly Gly Asn Arg Gln Ala His Lys Lys Val His Gln 290 295 300Lys Thr Lys Asp Phe Ile Cys Arg Leu Glu Gly Cys Gly Lys Glu Phe305 310 315 320Thr Gln Arg Gly Asn Leu Lys Ser His Gln Asn Lys Ser His Gln Gln 325 330 335Phe Met Asp Gln Thr Met Ala Arg Leu Glu Lys Ile Ser Leu Glu Asn 340 345 350Met Ser Pro Glu Asp Arg Glu Leu Val Ile Tyr Leu Ala Pro Leu Tyr 355 360 365Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Val Arg Pro Pro Gly 370 375 380Tyr Arg Leu Ser Arg Ser Asp Arg Ser Ser Ser Met Ser Ser Ser Ala385 390 395 400His Ser Tyr Ser Pro Thr Lys Ser Glu Ala Ser Leu Thr Ser Ser Pro 405 410 415Cys Thr Ala Gly Pro Pro Pro Gln His His Tyr Gly Gly His Ala Gln 420 425 430Gln His His His Gln Gln Gln Gln Gln Gln His Gln Gln Arg His Pro 435 440 445Asp His Gln Asp Met Ser Ser Tyr His Pro Ser Asn Pro Val Pro Thr 450 455 460His His His Gln Arg Pro Gln Gln Gly Leu Ala Tyr Pro Pro Val Ser465 470 475 480Phe Gly Ser Ala Pro Ser Gly Asn Ile Arg Tyr Pro Tyr Asn Gly Ile 485 490 495Val His Arg Tyr Glu Met Pro Glu His Ser His Pro Tyr Ser Gly Ile 500 505 510Pro Val Thr Thr Ser Ser Ser Thr Ser Ser Pro Val Ala Thr Val Tyr 515 520 525Ser Asp Asp Ser Gly Ala Val Tyr Gln Ser Asp Asp Asn Gly Ala Arg 530 535 540Glu Leu Ala Phe Gly Glu Arg Met Cys545 550110463PRTArtificial Sequencesynthesized 110Met Ala Ala Val Val Ala Ser His His Val Gly Phe Trp His Glu Arg1 5 10 15Arg Asp Pro Thr Ile His Val Thr Asn Leu His Leu Ala Asn Met Met 20 25 30Ser Pro Tyr Asp Ile Pro Arg Thr Val Ala Asn Thr Ser Ala Ser Arg 35 40 45Ser Tyr Gln Pro Thr Thr Thr Gln Met Asp Met Gly Met Pro Ile Phe 50 55 60Ser Ala Thr Gly Leu Ser Ser Ser Val Pro Tyr Gln Ser Gly Ala Phe65 70 75 80Ala Phe Asp Pro Ile Ser Thr Asn Pro Tyr Asn Met Gln Gln Ser Ser 85 90 95Tyr Tyr Ser Ser Asn Ile Ala Gln Ala Val Thr Tyr Gly Thr Ala Pro 100 105 110Asp Val Gln Ser His Pro Thr Val Arg Asp Ala His Ser Ser Phe Leu 115 120 125Met Asn Arg Asn Thr Met Val Lys Ser Glu Ser Ala Ser Pro Ile Ser 130 135 140Ser Ala Pro Met Tyr Asn Asp His Ser Tyr Val Ala Glu Cys Arg Arg145 150 155 160Ala Ala Ser Glu Gln Thr Asp Arg Thr Gly Val Asn Phe Ala Thr Asp 165 170 175Val Asp Thr Leu Met Arg Ala Ile Gln Ala Lys Glu Pro Thr Thr Pro 180 185

190Gln Ala Lys Glu Ala Lys Gln Glu Thr Glu Val Lys Ile Ser Gln Lys 195 200 205Thr Arg Lys Arg Tyr Gln Cys Asn Ile Pro Asp Cys Ser Lys Ser Phe 210 215 220Phe Gln Lys Thr His Leu Asp Ile His Ile Arg Ala His Thr Gly Ala225 230 235 240Lys Pro Phe Asn Cys Lys Ala Pro Gly Cys Gly Gln Ser Phe Ser Gln 245 250 255Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly Glu Arg Pro 260 265 270Tyr Ser Cys Asp Ile Cys Gly Lys Thr Phe Ala Gln Arg Gly Asn Val 275 280 285Arg Ala His Lys Ile Val His Gln Gln Ile Lys Pro Phe Thr Cys Arg 290 295 300Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser305 310 315 320His Gln Asn Lys Phe His Ala Ala Thr Leu Arg Tyr Leu Thr Gln Lys 325 330 335Phe Ala Thr Ile Thr Pro Ser Asp Tyr Val Ser Gln Glu Asp Lys Glu 340 345 350Leu Trp Glu Tyr Phe Ala Ser Leu Tyr Lys Asn Ser Asn Lys Gly Ile 355 360 365Lys Gly Arg Gly Lys Asp Arg Arg Ile Ser Ala Ile Ser Ser Met Ala 370 375 380Asn Ser Asn Pro Ser Ser Tyr Ala Pro Met Pro Met Thr Ser Met Ser385 390 395 400Gln Ser Tyr Ser Gly Tyr Leu His His Ser Gly Ser Asp Arg Ser Ser 405 410 415Arg Ser Ser Ser Met Ser Thr Asp Ala Ile Arg Arg Ile Asp Asn Ser 420 425 430Tyr Asp Phe Asn Ala Pro Met Pro Thr Gly Tyr His His Gln Thr Gln 435 440 445Gly Thr Gly Tyr Asp Asp Met Val Phe Pro Glu Arg Lys Leu Tyr 450 455 460111449PRTArtificial Sequencesynthesized 111Met Asp Ile Gly Asn Leu Met Asn Gln Arg Gly Ala Ala Met Gln Gln1 5 10 15His Ala Ser Ile His Thr Gly Ser Thr Pro Glu Arg Gln Met His Gln 20 25 30Leu Pro Gln Leu Thr Ala Arg Asn Met Pro Glu Pro Pro Met Asp Arg 35 40 45Ala Gly Ser Pro His Gly Ser Glu His Ser Gln Phe Ser Arg His Thr 50 55 60Met Asp Gly Val Pro Arg Ser Tyr Pro Ser Pro Ser Ala Met Val Gly65 70 75 80Ala Pro Met Gln Met Gln Val Pro Val Ser His Met Gly Pro Gly Pro 85 90 95Val Ile Leu Pro Gly Ile Pro Gln His Asp Met Ser Gln Gly Met Pro 100 105 110Gln Tyr Lys Ala Pro Glu Gln Gln Val Ser Gln Gln Pro Thr Lys Ala 115 120 125Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu 130 135 140Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys Asp145 150 155 160Phe Pro Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val 165 170 175His Gln Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys 180 185 190Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile 195 200 205His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys 210 215 220Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr225 230 235 240Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala Ala 245 250 255Arg Gly Ala Thr Met Lys Pro Asn Ala Thr Arg Ser Asp Gly Asp Ala 260 265 270Met Ser Asn Arg Gly Ser Pro Leu Thr Thr Pro Ser Pro Gly Gln Arg 275 280 285Thr Leu Ser Met Ser Pro Ser Ala Asp Ser Met His Arg Ala Asn Ser 290 295 300Glu Phe Gln Tyr Met Gly Asn Ser Ser Leu Pro Val His Leu Gln Arg305 310 315 320Asp Met His Val Gly Ser Pro Ala Ser Thr Ser Ser Gly Gly Tyr Asn 325 330 335Thr Gly Met Arg Pro Thr Ser His Pro Thr Ser Tyr Gly Pro Pro Pro 340 345 350Thr Leu Glu Pro Ser Val Glu Gln His Ser Gly Pro Gly Ser Ala Gly 355 360 365Gly Ser Pro His Met Ser Asn Val Gly Trp Gln Ser Pro Ser His Val 370 375 380Ala Ser Pro Ser His Ser Ser Asn Gly Gly Gly Tyr Thr Tyr Pro Asp385 390 395 400Pro Asp Gly Tyr Pro Ala Ala Pro Ser Leu Gly Gly Gln Met Phe Tyr 405 410 415Gly Asn Pro Gly Gln Val Arg Arg Pro Gln Ser Thr Glu Pro Pro Ala 420 425 430Gly Ala Tyr Asp Ile Lys Gly Arg Gln Ser Glu Leu Trp Ala Gly Ala 435 440 445His112396PRTArtificial Sequencesynthesized 112Met Asn Gly Leu Arg Tyr Pro Ser Pro Ser Gln Met Gln Ala Pro Met1 5 10 15Pro Met Leu Asn Asn Ser Asn Tyr Ile Pro Asn Pro Pro Asp His Ala 20 25 30Tyr Ala Gln Gln Gln Gln Met Pro Asp Asn Gln Val Gln His Gln His 35 40 45Asn Gly Gly Arg Pro Ala Ser Asp Thr Gly Pro Pro Lys Ala Phe Ala 50 55 60Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg65 70 75 80His Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys Asp Tyr Pro 85 90 95Asn Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln 100 105 110Arg Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys 115 120 125Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser 130 135 140Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe145 150 155 160Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr 165 170 175Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala Ser Arg Ala 180 185 190Ser Ala Ser Ser Arg Thr Gly Arg Ser Asp Gly Gly Asp Tyr Ser Glu 195 200 205Thr Ala Ser Pro Leu Gly Thr Pro Ser Pro Asn Asp Arg Thr Leu Ser 210 215 220Leu Ser Pro Ala Asn Gly Met Pro Ala Gly Gly Met Pro Gly Leu His225 230 235 240Arg Gln Gly Ser Asp Tyr Ala Tyr Met Gly Gly Ile Asn Val Pro Pro 245 250 255His Met Arg His Glu Met Pro Gln Pro Ser Pro Arg Ala Ser Pro Ala 260 265 270Leu Thr Ala Gln Ser Tyr Thr Ser Asn Val Ser Gly Ser Arg Pro Ala 275 280 285Ile Thr Ser His Pro Ser Ala Tyr Gly Pro Pro Pro Ile Leu Glu Pro 290 295 300Pro Ala Ser Ala Asn His Asn Gln Ser Gly Gly Thr Asn Ser Ala Asn305 310 315 320Gly Ser Pro His Met Ser Ala Met Gly Trp Gln Ser Pro Gly Gln Gln 325 330 335Ala Leu Pro Ser Pro Gly Ala Gly Asp Asn Gly Tyr Val Tyr Pro Glu 340 345 350Pro Gln Tyr Gln Ala Gln Asn Gly Met Tyr Tyr Gln His Asn Asn Ile 355 360 365Arg Arg Pro Asn Ser Thr Glu Pro Asp His Tyr Asn Pro Asn Gln Gln 370 375 380Arg Met Gly Asn Glu Met Trp Ala Pro Ala Val Gln385 390 395113330PRTArtificial Sequencesynthesized 113Met Asn Ala Gly Ile His His Tyr Lys Pro Pro Gly Val Pro Val Glu1 5 10 15Pro Gln Pro Ala Gln Gln Val Lys Ala Tyr Pro Cys Gly Thr Cys Gly 20 25 30Lys Arg Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His 35 40 45Ser Gly Ile Arg Pro His Val Cys Asp Tyr Pro Asn Cys Gly Lys Gln 50 55 60Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln Arg Val His Thr Gly65 70 75 80Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser 85 90 95Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr 100 105 110Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr 115 120 125Leu Thr Arg His Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala 130 135 140Ala Ala Thr Ala Ala Ala Leu Ala Ala Arg Ala Ser Val Lys Pro Gly145 150 155 160Ser Thr Arg Ser Asp Gly Asp Ser Met Ser Asn Arg Gly Ser Pro Met 165 170 175Thr Thr Pro Ser Pro Ala Gln Arg Thr Leu Ser Met Ser Pro Ser Ala 180 185 190Asp Gln Met Gln Arg Ser Asn Ala Glu Phe Gly Tyr Met Gly Asn Thr 195 200 205Ser Leu Pro Val His Leu Gln Arg Asp Met His Val Gly Ser Pro Ala 210 215 220Ser Thr Thr Ser Ala Gly Tyr Ser Asn Gly Val Arg Pro Thr Ser His225 230 235 240Pro Thr Gly Tyr Gly Met Val Pro Pro Pro Thr Leu Glu Pro Asn Val 245 250 255Glu Gln His Ser Gly Pro Gly Ser Ala Gly Gly Ser Pro His Met Ser 260 265 270Thr Met Gly Trp Gln Ser Pro Ser His Val Ala Ser Pro Ser His Ser 275 280 285Asn Asn Gly Ser Ala Tyr Met Tyr Pro Glu Pro Glu His Tyr Pro Ala 290 295 300Gly Pro Thr Leu Gly Asn Gln Met Phe Phe Gly Gln Val Arg Arg Pro305 310 315 320Gln Ser Thr Glu Pro Pro Ala Ala Ala Tyr 325 330114447PRTArtificial Sequencesynthesized 114Met Asp Ile Thr Asn Ile Leu Asn Glu Lys Gly Thr Ala Ala Ala Ala1 5 10 15Val Ala Lys Ala Gln Leu His Gln His Leu Thr Gln Gly Thr His Ile 20 25 30Lys Ser Gln Thr Pro Ser Glu Met Gly Ser Glu Asn Gly Thr Ser Gln 35 40 45Asn Gly Asp Gln Ser Asn Ile Tyr Pro Pro Thr Ser Gln Pro His Ser 50 55 60His Leu Ala Gly Ile Pro Gln Tyr His Pro Pro Ser Gln Gly Ala Gly65 70 75 80Gly Val Pro Ala Ala Arg Ser Asp Phe Val Gln Ala Asp Gln Gly Asp 85 90 95Val Lys Tyr Leu Pro Asn Ala Asn Thr Gly Arg Gly Arg Ala Ser Gly 100 105 110Glu Pro Ala Pro Lys Thr Phe His Cys Ser Thr Cys Gly Lys Gly Phe 115 120 125Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile 130 135 140Arg Pro His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln145 150 155 160Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 165 170 175His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 180 185 190Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 195 200 205Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 210 215 220His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr225 230 235 240Glu Ala Asn Leu Arg Gln Asn Lys Glu Arg Val Ile Arg Pro Pro Asp 245 250 255Gly Ile Tyr Ser Glu Thr Gly Ser Thr His Ser Thr Pro Ser Pro Gly 260 265 270Gln Arg His Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Met Asn Leu 275 280 285His Arg Gln Met Gly Asp Tyr Tyr Met Gly Asn Asn Thr Ser Ile Pro 290 295 300Pro His Leu Arg Gly Asp Phe Gln Gln Pro Ser Pro Arg Ala Ser Pro305 310 315 320Ser Thr Ser Ser Pro Pro Val Ser Thr Tyr Asn Asn Val Pro His Ala 325 330 335Arg Pro Ser Leu Thr Ser His Pro Ser Gly Tyr Gly Pro Pro Gln Pro 340 345 350Leu Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Gly Ser Gly 355 360 365Ser Pro His Ile Ser Ser Met Gly Trp Ala Ser Pro Thr Leu Asn Ser 370 375 380Val Gly Ser Pro Ala Ser Ala Ser Ala Thr Glu Tyr Ser Tyr Pro Glu385 390 395 400Pro Ser Gly Pro Pro Tyr Ser Ala His Met Pro Pro His Met Tyr Phe 405 410 415Pro Asn Ser Thr Ile Arg Arg Pro Gln Ser Thr Glu Pro Glu Asn Tyr 420 425 430Glu Met Lys Pro Lys Leu Asn Gly Asp Ser Trp Thr Thr Pro Val 435 440 445115423PRTArtificial Sequencesynthesized 115Met Ala His Thr Glu Leu Leu Pro Arg Pro Thr Phe Gln Pro Ala Pro1 5 10 15Tyr Gly Ser Ala Gly Gly Val Val Ala Leu Gln Gln Leu Gln Leu Asp 20 25 30His Arg Pro Leu Gln Gln His Gln His His Pro Gln Pro Pro Gln Gln 35 40 45Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Arg Leu 50 55 60Gln Gly Phe Val Pro Tyr Gln Gln Thr Ala Leu Ala Gln Ser Ala Pro65 70 75 80Ser Pro Val Tyr Tyr Ala Ser Ser Gln Met Ala Pro Ile Gly Gln His 85 90 95Val Pro Phe Ala Ser Asp Ala Gln Arg Gln Ser Val Met His Tyr Gln 100 105 110Met Gly Ser Ser Thr His Pro Leu Pro Gln Ser Phe Met Pro His Pro 115 120 125Val Pro Val Thr Leu His Asp Leu Gln Ala Gln Leu Val Gln Asn Pro 130 135 140Ile Ser Gly Leu Ser Gln Pro Gln His Leu His Leu Val Gln Pro Ala145 150 155 160Thr Thr Gln Gln Gly Gly Met Pro Gln Pro Gln Met Ser Ser Arg Gln 165 170 175Arg Val Arg Arg Lys Ser Ser Thr Glu Gly Ser Thr Thr Ser Ser Asp 180 185 190Asp Lys Thr Ala Gly Leu Ala Gln Ala Ala Ser Ala Gln Val Thr Ala 195 200 205Thr Pro Val Ser Ser Val Gln Ala Ala Thr Ala Pro Ala Val Ala Pro 210 215 220Ala Val Pro Arg Thr Val Phe Val Asp Asn Ser Val Ala Gly Ala Ser225 230 235 240Ser Thr Phe Gln Cys Glu Trp Gln Gly Cys Ser Asp Ser Phe Leu Ser 245 250 255Phe Ser Asp Phe Val Ser His Val Thr Asp Glu His Ile Gly Ser Gly 260 265 270Leu Arg Phe Tyr Phe Cys Asp Trp Lys Asn Cys Met Gln Ala Gly Asn 275 280 285Pro Phe Arg Lys Arg His Lys Ile Met Thr His Val Arg Ile His Thr 290 295 300Gly Glu Lys Pro His Ser Cys Ser Val Pro Gly Cys Gly Lys Arg Phe305 310 315 320Pro Arg Ile Asp Ser Leu Arg Ala His Met Gln Val His Ser Gly Thr 325 330 335Arg Lys Phe Thr Cys Pro Leu Ala Thr Cys Met Arg Ser Tyr Tyr His 340 345 350Pro Arg Ser Leu Arg Lys His Val Arg Thr Lys Gln His Gly Asp Ala 355 360 365Asp Ala Ile Ile Arg Glu Ile Leu Glu Ser Arg Arg Ala Thr Gly Asp 370 375 380Ala Gln Asp Asp Ser Asp Asn Leu Glu Glu Glu Glu Glu Glu Glu Glu385 390 395 400Glu Asp Thr Asp Gly Asp Asp Ser Ala Asp Gly Ser Gly Asp Gly Gly 405 410 415Ser Gln Ser His Ser Pro Arg 420116356PRTArtificial Sequencesynthesized 116Met His Ser Ser Ser Met Ile Pro Gln Tyr Asp Thr Ser Arg Ala Ala1 5 10 15Thr Ser Ala Pro Val Ser Arg Ser Phe Gln Pro Thr Ser Thr Gln Met 20 25 30Asp Met Ser Met Pro Leu Tyr Ser Ser Asn Gly Leu Pro Thr Thr Val 35 40 45Pro Tyr Gln Pro Gly Gln Phe Ala Tyr Asp Thr Ala Pro Val Asn Pro 50 55 60Tyr Thr Met Gln Gln Pro Ser Tyr Tyr Gln Ser Gly Ile Pro His Pro65 70 75 80Val Ser Tyr Pro Pro Ser Thr Asp Val Gln Gln Leu Pro Thr Glu Asp 85 90 95Ala Thr Lys Pro Ser Gln Lys Pro Arg Lys Arg Tyr Gln Cys Thr Val 100 105 110Pro Asn Cys Asn Lys Ser Phe Tyr Gln Lys Thr His Leu Glu Ile His 115 120 125Ile Arg

Ala His Thr Gly Ala Lys Pro Phe Asn Cys Lys Ala Pro Gly 130 135 140Cys Gly Gln Ser Phe Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg145 150 155 160Arg His Thr Gly Glu Arg Pro Tyr Ser Cys Asp Ile Cys Gly Lys Thr 165 170 175Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Val His Gln Gln 180 185 190Ile Lys Pro Phe Thr Cys Lys Leu Asp Asp Cys Gly Lys Gln Phe Thr 195 200 205Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala Thr Thr 210 215 220Leu Arg Tyr Leu Thr Thr Lys Phe Ala Thr Ile Ser Met Gly Asp Trp225 230 235 240Val Ser Lys Glu Asp Lys Glu Leu Trp Glu Tyr Phe Ala Ser Leu Tyr 245 250 255Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Ile 260 265 270Ser Ala Met Ser Ser Ser Ala Ser Ser Tyr Pro Ser Ser Tyr Pro Ala 275 280 285Met Pro Met Ala Ser Met Ser Arg Ser Tyr Gly Gly Ser Phe His His 290 295 300Ser Ser Glu Arg Ser Ser Arg Ser Ser Ser Met Ser Ser Asp Thr Ile305 310 315 320Gln Arg Val Asp Ser Gly Tyr Asp Phe Asn Val Pro Met Pro Thr Ser 325 330 335Tyr His Gln Pro Pro Ala Ser Gly Tyr Asp Asp Met Val Phe Pro Glu 340 345 350Arg Lys Leu Tyr 355117475PRTArtificial Sequencesynthesized 117Met Glu Leu Met Glu Leu Val Asp Asn Glu Pro Thr Ala Arg Pro Phe1 5 10 15Gln Cys Asp Trp Asp Gly Cys Glu Thr Lys Lys Gln Ser Phe Asn Arg 20 25 30Lys Ser Asp Leu Gln Arg His Tyr Arg Ile His Thr Asn Glu Arg Pro 35 40 45Tyr Gln Cys Asn Gln Pro Gly Cys Gly Lys Ser Phe Ile Gln Arg Ser 50 55 60Ala Leu Thr Val His Ile Arg Thr His Thr Gly Glu Lys Pro His Gln65 70 75 80Cys Gln His His Gly Cys Gly Lys Arg Phe Ser Asp Ser Ser Ser Leu 85 90 95Ala Arg His Arg Arg Ile His Thr Gly Lys Arg Pro Tyr Lys Cys Ala 100 105 110His Asp Gly Cys Leu Lys Ser Ser Phe Cys Arg Lys Thr Thr Met Val 115 120 125Lys His Gln Arg Arg Ser His Gln Arg Gly Ile His Ser Ser Glu Leu 130 135 140Asp Asp Ser Met Ser Asp Thr Gly Ser Glu Asp Ser Pro Ser Thr Pro145 150 155 160Lys Ser His Ser Ala Met Pro Trp Ala Thr Ala Gln Gln Gln His His 165 170 175His Ile Pro Met Met Gly Pro His Gly His His Leu Gln Arg Ala Ala 180 185 190Ser Phe Ala Asp Phe Gly Gln His Met Asn Gly Tyr Ser Leu Gln Gln 195 200 205Gln Tyr Asn Asn Gln His Arg His Ser Leu Ser Ser Gly Gly Ala Ala 210 215 220Glu Tyr His Gly Leu His Gln Asp Pro His Pro Gln Ala Val His His225 230 235 240His His Gln Gln Gln Pro Gln Pro Pro Gln His His His His Gln Asn 245 250 255Val Pro Val Val Leu Gln Arg Thr Ser Ser Leu Pro His His Ser Tyr 260 265 270Phe Val Ala Asp Ser Asn Asn Pro Gly Val Ala Thr Met Asn Thr Asn 275 280 285His Pro Gly Ala Pro Gln Val His His His Gln His Ala Pro Gln Tyr 290 295 300Gln Thr Ile Pro Arg Gln Ala Pro Val Glu Met Thr Tyr Pro Ser Ala305 310 315 320Pro Gly Leu Ala Ala Ser Ile Gln Ser Ser Pro Ser Ser Phe Ser Ala 325 330 335Gly Ser Gly Arg Ser Pro Ser Thr Gln Glu Gly Phe Tyr Thr His Ala 340 345 350Pro Pro Ala Gln Ala Ala Thr Tyr Ala Leu His Ala Thr Ser Pro Val 355 360 365Val Glu Thr Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 370 375 380Gln Gln Gln Asn Met Tyr Pro Pro Pro Gln Gln Ala Gln Ala Gln Pro385 390 395 400Thr Ser Gln Pro Gln Glu Gln Lys Tyr Tyr Glu Pro Gln Pro Val Arg 405 410 415Glu Glu Glu Pro Gln Gln Asn Trp Tyr Ser Gly Ala His Ala Val Tyr 420 425 430Gln Pro Pro Val Glu Val Ala Thr Ile Gly Gly Tyr Ala Ala Gly Gly 435 440 445Val Tyr Asp Pro Trp Gly Thr Gly Pro Lys Leu Glu Phe Asp Asp Gly 450 455 460Met Gln Leu Pro Ser Ala Arg Ile Glu Ser Met465 470 475118464PRTArtificial Sequencesynthesized 118Met Ala Ala Val Val Ala Pro His Gln Thr Pro Gly Leu Trp Gln Glu1 5 10 15Arg Arg Glu Pro Ser Phe Gln Met Pro Ser Ser Met His Gln Ser Ser 20 25 30Met Met Pro Gln Tyr Asp Ala Thr Arg Ser Val Thr Ser Ala Pro Val 35 40 45Ser Arg Ser Phe Gln Pro Thr Ser Thr Gln Met Asp Met Ser Met Pro 50 55 60Leu Tyr Thr Ser Asn Gly Leu Pro Thr Ser Ala Pro Tyr Gln Ser Gly65 70 75 80Gly Ala Phe Ala Tyr Asp Pro Ala Ser Val Asn Pro Tyr Thr Met Pro 85 90 95Gln Ser Ser Tyr Tyr Ser Ser Ser Ile Pro Asn Pro Val Ser Tyr Pro 100 105 110Pro Ser Ser Asp Val Gln Ser Leu Pro Thr Val Arg Asp Gly Arg Asn 115 120 125Leu Phe Asn Pro Met Val Lys Ala Glu Ser Thr Ser Pro Leu Gln Ser 130 135 140Asn Pro Ile Tyr Asn Asn Ser Asn Ser Asp Thr Asn Tyr Ser Ala Asp145 150 155 160Cys Lys Arg Ser Asn Ser Glu Pro Thr Glu Ser Asn Thr Val Asn Phe 165 170 175Ser Thr Asp Val Asp Thr Leu Met Arg Ala Ile Gln Ala Lys Gln Thr 180 185 190Asn Ala Pro Glu Pro Thr Glu Pro Lys Asp Glu Thr Thr Lys Pro Ser 195 200 205Gln Lys Pro Arg Lys Arg Tyr Gln Cys Thr Val Pro Asn Cys Asn Lys 210 215 220Ser Phe Tyr Gln Lys Thr His Leu Glu Ile His Ile Arg Ala His Thr225 230 235 240Gly Ala Lys Pro Phe Asn Cys Lys Ala Pro Gly Cys Gly Gln Ser Phe 245 250 255Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly Glu 260 265 270Arg Pro Tyr Ser Cys Asp Ile Cys Gly Lys Thr Phe Ala Gln Arg Gly 275 280 285Asn Val Arg Ala His Lys Ile Val His Gln Gln Ile Lys Pro Phe Thr 290 295 300Cys Lys Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly Asn Leu305 310 315 320Lys Ser His Gln Asn Lys Phe His Ala Ala Thr Leu Arg Tyr Leu Thr 325 330 335Thr Lys Phe Ala Thr Ile Ser Met Gly Asp Trp Val Ser Lys Glu Asp 340 345 350Lys Glu Leu Trp Glu Tyr Phe Ala Ser Leu Tyr Lys Asn Ser Asn Lys 355 360 365Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Ile Ser Ala Met Ser Ser 370 375 380Ser Ala Ser Ser Tyr Pro Ser Ser Tyr Ala Ala Leu Pro Met Ser Ser385 390 395 400Leu Ser Arg Ser Phe Gly Gly Pro Phe His Gln His Ser Ser Glu Arg 405 410 415Ser Ser Arg Ser Ser Ser Met Ser Ser Asp Ser Ile Gln Arg Val Asp 420 425 430Ser Gly Tyr Asp Phe Asn Val Pro Met Pro Thr Gly Tyr His Gln Pro 435 440 445Pro Ala Ser Gly Tyr Asp Asp Met Val Phe Pro Glu Arg Lys Leu Tyr 450 455 460119312PRTArtificial Sequencesynthesized 119Met Ala Thr Leu Tyr Leu Gly Leu Glu Glu Asn Leu Leu Ser Ser Ser1 5 10 15Pro Asn Leu Arg Ser Tyr Ser Ile Ser Ser Thr Ser Ser Gly Ala Ser 20 25 30Cys Ser Thr Thr Gln Ser His Pro Ser Cys Tyr Arg Thr Leu Ala Pro 35 40 45Lys Ala Asp Asn Thr Ser Pro Met Ser Phe Pro Ser Arg Pro Phe Glu 50 55 60Asp Gly Phe Leu Gly Leu Arg Glu Arg Lys Thr His Asn Gly Gln Ser65 70 75 80Ile Ala Pro Asn Leu Leu Ser Ile Lys Val Glu Gly Ala His Gln Thr 85 90 95Ser Asn Pro Pro Leu Asp Pro Ala Phe His Pro Ser Gln Gln Met Glu 100 105 110Asp Met Leu Gln Gln Gln Gln Gln Asn Phe Ser Thr Pro Asn Tyr Asp 115 120 125Gln Ser Tyr Pro Arg Ile Thr Asn Tyr Pro Glu Tyr Gly Pro Gln Arg 130 135 140Tyr Ser Ser Asn Ser Leu Ser Pro Ser Ser Ser Asn Gly Asp Cys Leu145 150 155 160Tyr Thr Thr His Asn Arg Met Phe Asp Cys Ser Gln Ser Phe Ala Pro 165 170 175Trp Gly His Glu Ser Asn Ser Arg Glu Ala Cys Ala Ala Met Thr Ala 180 185 190Leu Glu Leu Leu Met Pro Lys Val Gly Ile Gly Ser Glu Gly Glu Glu 195 200 205Asp Val Asp Met Ser Asp Arg Asp Ser Ala Gly Ser Ser Pro Gly Pro 210 215 220Thr Val Ala Arg Arg Lys Arg Arg Ala Pro His Pro Leu Val Ile Ser225 230 235 240Ser Arg Asp Lys Pro His Val Cys Ser Val Gly Asp Cys Glu Ser Arg 245 250 255Phe Lys Arg Pro Glu His Leu Arg Arg His Glu Lys Thr His Thr Gly 260 265 270Glu Arg Pro Phe Ser Cys Thr Ile Cys Gly Arg Arg Phe Gly Arg Asn 275 280 285Asp Asn Leu Gln Thr His Lys Lys Thr His Met Lys Met Thr Gly Arg 290 295 300Asn Glu Tyr Ile Pro Gly Leu Ala305 310120467PRTArtificial Sequencesynthesized 120Met Asp Ile Thr Thr Ile Leu Asn Lys Lys Ala Ser Val Ser Ile Val1 5 10 15Ala Ala Asp Val His Gln Leu Gln Gln His Leu Ala Gln Ala Thr Ala 20 25 30Gln Ser Gln Thr Asp Asp Ala Val Lys Ser Arg Ser Pro Ser Glu Leu 35 40 45Gly Ala Ser Glu His His Arg Ser Ala Ser Ala Pro Pro Ser Glu His 50 55 60His His His His His His His Gln Pro Thr Ser Ser Phe Pro Ser Ser65 70 75 80Thr Gln Ser Leu Pro Gln Met Ala His Leu Ala Gln Tyr His Val Gln 85 90 95Ala Gln Ala Asn His Ala Ser Thr Ser Pro Gly Tyr Ala His Ser Ala 100 105 110His Gly Ser Asp Tyr Gly Arg Ser Thr Thr Ser Met Arg Pro Thr Gly 115 120 125Leu Pro Ala Leu Lys Thr Phe His Cys Gln Thr Cys Ser Lys Gly Phe 130 135 140Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile145 150 155 160Arg Pro His Ala Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln 165 170 175Arg Ser Ala Leu Thr Val His Thr Arg Val His Thr Gly Glu Lys Pro 180 185 190His Met Cys Asp Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu 195 200 205Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro 210 215 220Tyr Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg225 230 235 240His Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Ala Glu Thr 245 250 255Glu Ala Asn Leu Arg His Ser Lys Asp Arg Ser Thr Thr Ser Arg Pro 260 265 270Ser Glu Tyr Ser Glu Pro Gly Ser Ala His Ser Thr Pro Ser Pro Ala 275 280 285Gln Arg Pro Ser Leu Ser Pro Gly Asn Glu Leu Pro Pro Leu Asn Leu 290 295 300Ser Ser Arg Pro Pro Ala Ala Gly Gly Pro Thr Ser Ala Gly Gly Ala305 310 315 320Ala Asp Tyr Tyr Thr Ser Leu Pro Pro His Leu Arg Thr Asp Phe Ala 325 330 335Asn Ser Ser Pro Arg Ala Ser Pro Thr Ser Pro Ser Pro Thr Leu Thr 340 345 350Ser Leu Ser Gly Pro Ala Ser Phe His His His His Asn His Asn Arg 355 360 365Pro Ser Leu Thr Ser His Pro Ser Gly Tyr Ala Pro Pro Gln Pro Leu 370 375 380Glu Pro Pro Ala Asn Ser Asp Pro Arg Pro Asn Ser Val Ala Gly Ser385 390 395 400Pro His Leu Ser Ser Val Gly Trp Ala Ser Pro Thr Leu Ser Ser Met 405 410 415Pro Ser Pro Ser Ser Ala Ser Ala Pro Glu Tyr Pro Tyr Pro Glu Pro 420 425 430Ser Asn His Gln Tyr Pro Gly Ser Ile Thr Pro His Met Phe Phe Pro 435 440 445Arg Arg Pro Gln Ser Ser Glu Pro Glu Asn Tyr Glu Leu Lys Pro Lys 450 455 460Leu Glu Leu465121402PRTArtificial Sequencesynthesized 121Met Lys Ser Glu Pro Gly Val Thr Glu Ser Ala Asp Gln Pro Val Leu1 5 10 15Ser Tyr Pro Pro His Ala Pro Leu Pro Ser Met Pro Gln Asp Val Arg 20 25 30Tyr Ala Pro Gln Ser His Pro Ala Pro Gly Met Pro Leu Met Gln Thr 35 40 45Pro Tyr Val Pro Gly Gly Tyr Ala Ser Gly Ala Pro Met His Asn Gly 50 55 60Ala Ala Pro Pro Pro Arg Thr Glu Pro Pro Pro Lys Thr Phe His Cys65 70 75 80Gly Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His 85 90 95Glu Arg Ile His Ser Gly Ile Arg Pro His Ala Cys Asp Trp Pro Gly 100 105 110Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg 115 120 125Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro 130 135 140Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly145 150 155 160Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asn Cys Gln Lys Thr Phe Thr 165 170 175Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile 180 185 190Glu Glu Ala Ala Ala Glu Thr Glu Ala Asn Leu Arg Gln Asn Lys Glu 195 200 205Arg Ser Arg Gly Pro Gly Glu Pro Met Phe Ser Asp His Ala Ser Val 210 215 220His Ser Thr Pro Ser Pro Ala His Ser Gly Ile Ser Ala Gly Gly Glu225 230 235 240Leu Pro Pro Leu Asn Met Pro Arg Ser Thr Gly Asp Tyr Tyr Met Gly 245 250 255Ser Gly Ser Ile Pro Pro His Val Arg Gly Asp Phe Ser Gln Ala Ser 260 265 270Pro Arg Ala Ser Pro Thr Ala Thr Ser Pro Ser Leu Ser Ser Phe Gly 275 280 285Ser Ala Pro His Ser Arg Pro Ser Met Thr Ser His Pro Thr Gly Tyr 290 295 300Gly Pro Pro Gln Pro Leu Glu Pro Pro Ala Asn Asn Asp His Arg Pro305 310 315 320Asn Ser Val Ser Gly Ser Pro His Met Pro Thr Leu Gly Trp Ala Ser 325 330 335Pro Ser His Gly Ser Ile Pro Ser Pro Gly Ser Ala Asn Asp Phe Pro 340 345 350Tyr Pro Glu Pro Gly Ala Pro Ala Tyr Pro Ser Ser Val Pro Pro His 355 360 365Met Tyr Phe Ser His Ser Ala Gly Arg Arg Pro Thr Ser Thr Glu Pro 370 375 380Glu Asn Tyr Glu Met Lys Pro Lys Met Gly Asp Asn Ser Trp Ser Thr385 390 395 400Pro Val122404PRTArtificial Sequencesynthesized 122Met Leu Asn Asn Lys Val Thr Ser Ala Gln Tyr Gln Gln His Met Ala1 5 10 15Gln Ala Ser Tyr Pro Ser Pro Ser Gln Leu Gln Asp Pro Leu Ser Met 20 25 30Leu Gly Thr Asn Tyr Ser Glu Arg Pro Phe Glu Asn Met Tyr Leu Pro 35 40 45Gln His Gln Asn Glu His His Met Ser Ser His Asp Ala Ser Asp Ser 50 55 60Gln Arg Gln Ser Ser Asn Gly Ala Ile Lys Ala Phe Ala Cys Thr Asn65 70 75 80Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg 85 90 95Ile His Thr Gly Asp Arg Pro His Val Cys Pro Glu

Lys Gly Cys Gly 100 105 110Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Met Arg Val His 115 120 125Ser Gly Glu Lys Pro His Met Cys Glu Arg Leu Ile Arg Val Leu Trp 130 135 140Leu Gly Ile Val Ala Tyr Ile Leu Gly Lys Arg Pro Tyr Lys Cys Pro145 150 155 160Phe Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg 165 170 175His Gln Asn His His Thr Gly Thr Val Glu Glu Ala Ala Val Ala Thr 180 185 190Ala Ala Ala Leu Ala Ser Arg Thr Pro Gly Ile His Pro Arg Asn Gly 195 200 205Ser Asp Gly Gly Asn Phe Ser Asp Thr Ala Ser Met Ser Ser Ala Met 210 215 220Thr Arg Thr Pro Ser Pro Pro Glu Arg Gln Leu Ser Met Ser Pro Asn225 230 235 240Asp Asp Val Pro His Met Pro His Leu Asn Arg Arg Thr Ser Gly Val 245 250 255Ser Tyr Ser Ser Ser Asp Ser Cys Pro Leu Pro Ala His Phe Arg Pro 260 265 270Gly Leu Gln Gln Pro Ser Pro Arg Ser Ser Pro Ser Val Ser Ser Pro 275 280 285Thr Leu Ser Ala Phe Gly Gly Asn Asn Ser Tyr His Arg Pro Ser Leu 290 295 300Thr Ser His Pro Thr Leu Pro Val Leu Glu Pro Pro Thr Tyr His Asp305 310 315 320Leu Arg Gln Pro Ala Ser Gly Ser Gly Ser Pro His Phe Gly Ser Thr 325 330 335Gly Trp Gln Ser Pro Val Ala Ala Gly Leu Pro Ser Pro Gly His Asn 340 345 350Asp Gly Gly Phe Trp Asn Pro Asp Pro Gln Tyr Gly Pro Asn Gln His 355 360 365Leu Tyr Tyr Pro Ser Ser Asn Met Arg Arg Pro Gln Ser Thr Glu Pro 370 375 380Asp His Tyr Glu Leu Lys Pro Arg Leu Pro Ser Thr Gly Val Trp Ala385 390 395 400Gly Thr Met Gly123457PRTArtificial Sequencesynthesized 123Met Ala Ala Val Val Ala Ser His His Met Gly Leu Trp Gln Asp Arg1 5 10 15Arg Glu Thr Pro Ala His Leu Ser Asn Met His Leu Ser Asn Met Met 20 25 30Pro Ser Tyr Asp Ala Ser Arg Thr Val Ser Asn Ala Pro Val Ser Arg 35 40 45Ser Tyr Gln Pro Thr Ser Ser His Met Asp Ile Asn Met Pro Leu Tyr 50 55 60Ser Ala Asn Gly Leu Pro Thr Ser Val Pro Tyr Gln Ser Gly Ala Phe65 70 75 80Ala Tyr Asp Pro Thr Pro Val Asn Ala Tyr Asn Met Gln Gln Pro Ser 85 90 95Tyr Tyr Gln Ser Asn Ile Gln His Pro Val Ser Tyr Ala Pro Thr Ser 100 105 110Asp Val Gln Gln Leu Pro Thr Val Arg Asp Ala Arg Asn Val Phe Asn 115 120 125Asn Met Val Lys Ser Glu Ser Thr Ser Pro Val Gln Ser Asn Pro Met 130 135 140Tyr Asn Asn Thr Ala Tyr Ser Ala Asp Ile Lys Arg Ser Thr Ser Glu145 150 155 160Pro Thr Glu Gly Ser Ser Ala Ser Phe Ala Thr Asp Val Asp Thr Leu 165 170 175Met Arg Ala Ile Gln Ala Lys Gln Thr Thr Ser Pro Gln Ala Ser Glu 180 185 190Pro Lys Glu Glu Ala Val Lys Val Ser Gln Lys Pro Arg Lys Arg Tyr 195 200 205Gln Cys Thr Ile Pro Asn Cys Asn Lys Ser Phe Tyr Gln Lys Thr His 210 215 220Leu Glu Ile His Ile Arg Ala His Thr Gly Ala Lys Pro Phe Asn Cys225 230 235 240Lys Ala Pro Gly Cys Gly Gln Ser Phe Ser Gln Leu Gly Asn Leu Lys 245 250 255Thr His Glu Arg Arg His Thr Gly Glu Arg Pro Tyr Ser Cys Asp Ile 260 265 270Cys Gly Lys Thr Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile 275 280 285Val His Gln Gln Ile Lys Pro Phe Thr Cys Lys Leu Asp Asp Cys Gly 290 295 300Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe305 310 315 320His Ala Ala Thr Leu Arg Tyr Leu Thr Gln Lys Phe Ala Thr Ile Thr 325 330 335Ser Gly Asp Trp Val Ser Gln Glu Asp Lys Glu Leu Trp Glu Tyr Phe 340 345 350Ala Ser Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys 355 360 365Asp Arg Arg Ile Ser Ala Met Ser Ser Ser Ala Ser Ser Tyr Pro Ser 370 375 380Ser Tyr Ala Gly Met Pro Met Val Pro Met Ser Arg Ser Tyr Ala Gly385 390 395 400Ser Phe His Gln Gln Ser Ser Asp Arg Ser Ser Arg Ser Ser Ser Met 405 410 415Ser Ser Asp Ser Leu His Arg Val Asp Ser Ala Tyr Asp Phe Gly Ala 420 425 430Pro Ile Pro Asn Pro Tyr His Gln Gln Pro Gly Thr Gly Tyr Asp Asp 435 440 445Met Val Phe Pro Glu Arg Lys Leu Tyr 450 455124437PRTArtificial Sequencesynthesized 124Met Gln Gln Pro His His Gly Ser Gly Ala Thr Pro Asp Arg Gln Ile1 5 10 15Pro Gln Leu Ser Gln Leu Thr Ala Arg Asn Leu Pro Glu Pro Pro Met 20 25 30Asp Arg Ala Ala Ser Pro His Gly Ser Glu His Ser Arg Tyr Ser Ala 35 40 45Pro Arg Ser Thr Leu Asp Thr Met Pro Arg Ser Tyr Pro Ser Pro Asn 50 55 60Pro Met His Gly Pro Pro Met Thr Met Pro Leu Pro Gly His Gly Gln65 70 75 80Gln Gln His Ile Ala Ala Pro Ala Ile Thr Met Ile Leu Pro Gly Ala 85 90 95Pro Pro Asp Met Gly Met Pro Lys Pro Ala Pro Ala Pro Gln Ala Pro 100 105 110Val Lys Ala Phe Pro Cys Ser Thr Cys Gly Lys Arg Phe Ala Arg Arg 115 120 125Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg Pro His 130 135 140Val Cys Asp Phe Pro Gln Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala145 150 155 160Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His Met Cys 165 170 175Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His 180 185 190Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp 195 200 205Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn 210 215 220His His Thr Gly Thr Val Glu Glu Ala Ala Ala Ala Thr Ala Ala Val225 230 235 240Leu Ala Ala Arg Thr Asn Ala Lys Pro Gly Ser Val Arg Ser Glu Gly 245 250 255Glu Gly Ile Ser Asn His Ala Ser Pro Leu Thr Thr Pro Ser Pro Gly 260 265 270Gln Arg Thr Leu Ser Met Ser Pro Ser Ala Asp Gln Met Gln Arg Ser 275 280 285Ala Thr Glu Phe Gln Tyr Met Gly Asn Ala Ser Leu Pro Val His Met 290 295 300Gln Arg Asp Met His Val Gly Ser Pro Val Pro Thr Thr Ser Ala Thr305 310 315 320Tyr Ser Asn Gly Met Arg Pro Thr Ser His Pro Thr Gly Tyr Gly Met 325 330 335Ile Pro Pro Pro Thr Leu Glu Pro Asn Val Glu Gln His Ser Gly Thr 340 345 350Gly Ser Ala Gly Gly Ser Pro Ala Met Ala Asn Met Gly Trp Gln Ser 355 360 365Pro Ser His Val Ala Ser Pro Ser His Asn Thr Asn Gly Asn Gly Tyr 370 375 380Met Tyr Pro Glu Pro Glu Asn Tyr Pro Ser Gly Pro Thr Leu Gly Gly385 390 395 400Gln Met Phe Tyr Ser Asn Pro Ala Pro Val Arg Arg Pro Gln Ser Thr 405 410 415Glu Pro Pro Ala Ala Ala Tyr Asp Val Lys Pro Arg Gln Asn Glu Leu 420 425 430Trp Thr Ser Ala His 435125463PRTArtificial Sequencesynthesized 125Met Ser Asp Pro Arg Pro Ala Val Ser Pro Ala Val Ser Val Ser Gly1 5 10 15Val Gly Ser Ala Pro Leu Gln Ser His Met Ser Leu Glu Ala Val Lys 20 25 30Gln Glu Thr His Gly Leu Gln Pro Leu Gln Gln His Tyr His His Gln 35 40 45Leu Ala Pro Leu Pro Met Asp Arg Ala Asp Ser Pro His Gly Ser Glu 50 55 60His Ser Arg Tyr Ser Val Pro Pro Leu Asn Gly Met Asp Gln Pro Arg65 70 75 80Pro Tyr Gly Ser Pro Ala Ala Met His Ala Pro Leu His Met Ser Asp 85 90 95Met Asn Arg Pro Pro Thr Ser Leu Pro Met Ser Ser Leu Pro Leu Pro 100 105 110Ser Ile Gln Pro Val Leu Ala Pro Ala Pro Pro Ala Ala Gly Ala Met 115 120 125Tyr Gly Thr Gln Glu Ala Pro Gln Pro Pro Pro Lys Ala Tyr Pro Cys 130 135 140Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His145 150 155 160Glu Arg Ile His Ser Gly Val Arg Pro His Ile Cys Asp Phe Pro Gly 165 170 175Cys Asn Lys Lys Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln Arg 180 185 190Val His Thr Gly Glu Lys Pro His Gln Cys Glu Arg Cys Gly Lys Pro 195 200 205Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly 210 215 220Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr225 230 235 240Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Ile 245 250 255Glu Glu Ala Ala Ala Ala Thr Arg Glu Ala Leu Ala Arg Gly Pro Thr 260 265 270Gly Thr Ala Arg Met Thr Pro Thr His Val Thr Arg Ser Glu Gly Asp 275 280 285Ala Gly Ser Gly Ser Asn His Ala Ser Pro Met Ser Thr Pro Ser Pro 290 295 300Ala His Arg Thr Asn Ser Met Ser Pro Ser Asn Glu Leu Ala Gly Ile305 310 315 320Gly Ser Ile Gln Ser Gln Tyr Val Asn Asn Ser Leu Pro Ser His Leu 325 330 335Arg Gly Asp Val His Ala Gly Ser Pro Thr Ser Thr Thr Ser Ser Gly 340 345 350Tyr Thr Asn Asn Arg Pro Thr Ser His Pro Thr Gly Tyr Gly Pro Pro 355 360 365Gln Val Leu Glu Pro Asn Ile Glu Thr Arg Pro Gly Pro Gly Ser Ala 370 375 380Ser Gly Ser Pro His Leu Gly Ser Val Gly Trp Gln Ser Pro Ser His385 390 395 400Ala Pro Ser Pro Ser His Ser Thr Ser Gly Phe Val Tyr Pro Asp Pro 405 410 415Glu Ala Tyr Pro Ser Ser Ala Gly Met Gly Pro Leu Phe Tyr Ser Ser 420 425 430Ala Ile Ala Gly Val Arg Ser Gly Ser Ala Glu Pro Gly Gln Asn Asn 435 440 445Asp Tyr Pro Lys Ser Arg Ser Ala Glu Leu Trp Ala Ser Ala Gln 450 455 460126440PRTArtificial Sequencesynthesized 126Met Glu Thr Ala Val Pro Val Thr Tyr Asn Val Pro Asn His Asp Met1 5 10 15Asn Ala Val Pro Pro Arg Arg Met Met Thr Pro Ser His His Asp Gln 20 25 30Asn Ile Ala Tyr Phe Ser Asn Pro Ser Ile Pro Tyr Ser Thr Ala Leu 35 40 45Gln Pro Pro Pro Phe Ser Gly Phe Gly His Ile Leu Asn Asn His His 50 55 60His Pro Ser Tyr His Ser Tyr Phe Ser Ser Asn Pro Asn His His Val65 70 75 80Asn Ser His His Pro Arg Leu Pro Ile Glu Ala Leu Pro Val Gln Pro 85 90 95Gln Leu Ser Asp Val Arg His Val Lys Asn Phe Ile Pro Arg Ser Ile 100 105 110Arg Pro Ser Pro Pro Lys Glu Asp His Ile Pro His Pro Pro Pro Gln 115 120 125Arg Val Asn Val Ala Pro Ala Arg Ala Arg Asn Val Thr Thr Gln His 130 135 140Asp Asp Pro Lys Gly Pro Thr Lys Pro Glu Val Asp Phe Gly Thr Glu145 150 155 160Val Asp Thr Leu Met Lys Thr Ile Gln Ala Lys Pro Gln Ser Ser Ser 165 170 175Pro Gln Val Glu His Gln Leu Pro Pro Leu Gln Gln Lys Phe Asn Asn 180 185 190Gly Val Pro Ser Trp Ile Gln Pro Ala Tyr Ala Asn Gln Met Pro Gly 195 200 205Asn Gln Gly Ile Phe Pro Thr Pro Pro Gln Asp Arg Ile Met Ser Thr 210 215 220Asn Gln Lys Pro Arg Arg Lys Tyr Glu Cys Thr Leu Pro Gln Cys Arg225 230 235 240Lys Ser Phe Phe Gln Lys Thr His Leu Asp Ile His Met Arg Ala His 245 250 255Thr Gly Asp Lys Pro Phe Thr Cys Lys Glu Pro Ser Cys Gly Gln Arg 260 265 270Phe Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg Arg His Thr Gly 275 280 285Glu Lys Pro Tyr Ser Cys Glu Ile Cys His Lys Lys Phe Ala Gln Arg 290 295 300Gly Asn Val Arg Ala His Lys Ile Thr His Glu Gln Ala Lys Pro Phe305 310 315 320Thr Cys Arg Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly Asn 325 330 335Leu Lys Ser His Gln Asn Lys Phe His Thr Gln Thr Leu Arg Asn Leu 340 345 350Thr Leu Arg Phe Glu Ser Ile Gly Asn Ser Asp Arg Met Ser Pro Gln 355 360 365Asp Lys Glu Leu Trp Asp Tyr Phe Ser Thr Leu Tyr Arg Asn Ser Asn 370 375 380Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Val Ser Thr Ala Lys385 390 395 400Arg Ser Thr Ser Thr Tyr Glu Gly Ser Val Ser Asp Ser Asp Glu Asp 405 410 415Leu Lys Ile Arg Ser Arg Ser Tyr Asp Arg Val Ser Ala Val Met Thr 420 425 430Leu Gly Gly Glu Asp Leu Gly Arg 435 440127415PRTArtificial Sequencesynthesized 127Met Ala Phe Tyr Ala Val Ala Ala Phe Lys Gly Ile Lys Asp Ser Lys1 5 10 15Pro Lys Phe Gly Gly Ile Gln Cys Val Asp Val Asn Met Leu Ser Pro 20 25 30Gly Thr Leu Asn Pro Gln Ser Gln Leu Ala Lys Leu Ile Gly Leu Met 35 40 45Lys Val Ile Pro Glu Asp Asp Leu His Thr Lys Arg Thr Phe Ile Ile 50 55 60Ile Thr Lys Phe Gln Val Val Leu Phe Ile Met Tyr Ile Tyr Gln Pro65 70 75 80Asp Ser Pro Glu Leu Phe Ser Asn Gly Tyr Met Leu Phe Val Glu Arg 85 90 95Trp Thr Gly Lys Ala Val Thr Thr Leu Asn Glu Ala Val Ser Arg Leu 100 105 110Gly Gly Met Phe Asp Gly Cys Trp Gln Asp Lys Ser Val Tyr Asn Val 115 120 125Asp Asn His Ser Thr Ala Arg Ile Leu Asn His Gln Val Pro Pro Ala 130 135 140Cys Ser Thr Arg Phe Thr Glu Ser Met Gln Ala Leu Ala Gly Met Pro145 150 155 160Met Glu Tyr Gly Gly Phe Pro Ile Thr Thr Thr Thr Ser Thr Glu Cys 165 170 175Thr Thr Lys Asp His Ser Gln Tyr Gln Gln Ser Asp Phe Asn Thr Ile 180 185 190Lys Asn Val Ala Leu Pro Gln Gln Tyr Gln Gln Ser Asp Phe Asn Thr 195 200 205Ile Lys Asn Val Ala Leu Pro Gln Gln Tyr Gln Gln Ser Asp Phe Asn 210 215 220Thr Thr Lys Asn Val Ala Leu Pro Gln Gln Tyr Gln Gln Ser Asp Phe225 230 235 240Asn Thr Thr Lys Asn Val Ala Leu Pro Gln Gln Tyr Gln Thr Ile Thr 245 250 255Asn Ser Asn Glu Arg Pro His Lys Cys Lys Glu Pro Gly Cys Gly Lys 260 265 270Ala Phe Thr Leu Ser Ser Gly Leu Lys Glu His Lys Asn Phe Thr His 275 280 285Ser Glu Lys Arg Pro His Lys Cys Lys Val Pro Asn Cys Gly Lys Ala 290 295 300Leu Lys Arg Arg Ser Ala Leu Val Ala His Lys Asn Gly Val His Ser305 310 315 320Asn Val Arg Pro His Lys Cys Glu Val Gln Asn Cys Gly Lys Ala Phe 325 330 335Lys Arg Pro Ser Glu Leu Lys Asn His Gln Asn Phe Thr His Ser Lys 340 345

350Glu Arg Pro Tyr Lys Cys Arg Val Pro Asn Cys Val Lys Ala Phe Arg 355 360 365Arg Pro Ser Asp Leu Tyr Gln His Glu His Gln Val His Ser Asn Glu 370 375 380Lys Pro Tyr Lys Cys Glu Val Pro Asn Cys Gly Lys Ala Tyr Lys Arg385 390 395 400Phe Thr Ser Leu Gly Lys His Tyr Ile Thr His Thr Asn Asn Ala 405 410 415128475PRTArtificial Sequencesynthesized 128Met Asp Ala Pro Val Thr Ser Ser Asp Ile Pro Gly Leu Ser Ser Leu1 5 10 15Val Asp Gln Arg Val Thr Pro Ser Pro Val Pro Ser Met His Leu Pro 20 25 30Ala Pro Val Pro Thr Pro Pro His Gly His Gln Glu Pro Leu Gln Leu 35 40 45Gln Pro Leu Gln Gln Tyr His Gln Leu Ser Gln Met Pro Val Asp Arg 50 55 60Ala Asp Ser Pro His Gly Ser Glu His Ser Arg Tyr Ser Ala Pro Pro65 70 75 80Met Asn Gly Ser Gly Met Asp Asn Ser Arg Pro Tyr Gly Ser Pro Ser 85 90 95Ala Met His Ala Pro Leu His Ile Ser Pro Pro Thr Ser Leu Pro Leu 100 105 110Gly Ser Asn Ile Ser Leu Pro Ala Ile Gln Gln Pro Ile Leu Ala Pro 115 120 125Ala Pro Pro Ala Met Met Ser Val Tyr Pro Pro Val Asn Gln Pro Pro 130 135 140Pro Pro Val Lys Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala145 150 155 160Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Ile Arg 165 170 175Pro His Val Cys Asp His Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg 180 185 190Ser Ala Leu Thr Val His Met Arg Val His Thr Gly Glu Lys Pro His 195 200 205Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala 210 215 220Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr225 230 235 240Ala Asn Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His 245 250 255Gln Asn His His Thr Gly Thr Ile Glu Glu Ala Ala Leu Ala Thr Arg 260 265 270Glu Ala Leu Ser Arg Asp Pro Asn Thr Thr Ala Arg Leu Thr Pro Gly 275 280 285Ala His His Arg Ser Asp Gly Glu Ala Val Val Thr Ser Asn His Ala 290 295 300Ser Pro Leu Thr Thr Pro Ser Pro Ala His Arg Thr His Ser Met Ser305 310 315 320Pro Ser Asn Glu Leu Ala Gly Ile His Thr Leu Gln Thr Gln Tyr Pro 325 330 335Asn Ser Ser Leu Pro Ser His Leu Arg Ser Asp Val His Ile Ala Ser 340 345 350Pro Thr Ser Thr Thr Ser Ser Gly Tyr Asn Gly Asn Arg Pro Thr Ser 355 360 365His Pro Ser Gly Tyr Gly Pro Pro Ser Val Leu Glu Pro Ser Ile Glu 370 375 380Thr Arg Pro Gly Pro Gly Ser Ala Ser Gly Ser Pro His Met Gly Ser385 390 395 400Val Gly Trp Gln Ser Pro Ser His Ala Gly Ser Pro Ser His Ser Ala 405 410 415Ser Gly Phe Val Tyr Pro Asp Pro Glu Ala Tyr Pro Gly His Ala Gly 420 425 430Leu Ser Gly Asn Leu Gly Ser Leu Phe Tyr Gly Ser Ala Val Asn Ser 435 440 445Thr Arg Ala Gly Ser Ser Glu Pro Gly Gln Gly Gly Asp Tyr Pro Lys 450 455 460Pro Arg Thr Ser Glu Leu Trp Ala Ser Ala Gln465 470 475129447PRTArtificial Sequencesynthesized 129Met Glu Thr Ala Glu Pro Val Ser Tyr Glu Phe Pro Gly His Ala Val1 5 10 15Gly Ala Val Ala Pro Arg Arg Met Met Gly Ser Asn Val Gly His Asn 20 25 30Phe Pro Phe Tyr Thr Asn Pro Thr Gly Gly Tyr Thr Leu Pro Phe His 35 40 45Gln Ser Ser Ser Pro Ala Tyr Ser Phe Gly His Thr Leu Asn His His 50 55 60His His His His His His His Pro Gly Tyr Gln His Tyr Phe Val Ala65 70 75 80Gly Gln Gln Pro Ile Asn Pro Gln Pro Val Arg Leu Ser Ser Glu Pro 85 90 95Pro Ser Ile Gln Gln Ile Pro Asp Ile Arg Pro Ala Lys Asn Ala Val 100 105 110Asn Arg Val Ala Arg Asp Pro Leu Met Lys Ile Glu His Asn Gly Ala 115 120 125Ser Gln Gln Pro Pro Gly Ala Gln Ser Ser Ser Asn Glu Glu Gly Ala 130 135 140Gln Gly Lys Ser Ser Ser Ser Asn Glu Val Glu Phe Ser Thr Glu Val145 150 155 160Asp Ile Leu Met Lys Ala Ile Gln Ala Lys Ala Ser Ala Gln Ser Pro 165 170 175Gly Val Gln Ser Leu Pro Pro Leu Gln Gln Leu Thr His Gly Gly Ser 180 185 190Asn Gly Tyr Pro Gln Ser Tyr Ser Met Pro Val Thr Thr Pro Arg Cys 195 200 205Thr Val Met Val Glu Glu Ala Pro Ser Arg Ser Gly Lys Lys Arg Lys 210 215 220Tyr Ala Cys Thr Leu Pro Gln Cys Gly Lys Ser Phe Ala Gln Lys Thr225 230 235 240His Leu Asp Ile His Met Arg Ala His Thr Gly Asp Lys Pro Phe Val 245 250 255Cys Lys Glu Pro Ser Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu 260 265 270Lys Thr His Gln Arg Arg His Thr Gly Glu Lys Pro Phe Ser Cys Asp 275 280 285Ile Cys Gln Lys Arg Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys 290 295 300Ile Thr His Gln His Ala Lys Pro Phe Thr Cys Leu Leu Asp Asp Cys305 310 315 320Gly Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys 325 330 335Phe His Ala Thr Thr Leu Arg Asn Leu Thr Met Lys Phe Ser Gln Val 340 345 350Thr Glu Gly Asp His Met Ser Pro Gln Asp Arg Lys Leu Trp Glu Tyr 355 360 365Phe Ala Thr Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly 370 375 380Lys Asp Arg Arg Ile Ser Pro Thr Ser Arg Ser Asp Pro Gly Ser Glu385 390 395 400Ser Arg Arg Arg Ile Glu Pro Leu Ser Ser Thr Asp Asp Lys Met Arg 405 410 415Arg Ala Ser Tyr Gly Asp Thr Ser Met Tyr Asn Gly Gly Ser Ser Ser 420 425 430Asp Asp Asp Asp Ala Glu Pro Tyr Phe Ile Glu Arg Gln Ala His 435 440 445130439PRTArtificial Sequencesynthesized 130Met Ser Gly Met Arg Ser Pro Ala Pro Thr Glu Val Met Asp Ile Thr1 5 10 15Asn Met Leu Asn Lys Lys Gly Gln Met Gln Gln Leu Thr Ser Gly Leu 20 25 30Leu Asp His His Gln Tyr Gln His Ser Phe Val Lys His Glu Pro Gly 35 40 45Met Glu Arg Ser Ala Ser Pro His Gly Ser Glu His Ser Gln Tyr Ser 50 55 60Asn Pro His Asn Ile Ala Arg Ala Tyr Pro Ser Pro Ser Thr Met Gln65 70 75 80Ala Pro Met His Ile Pro Asn Pro Met Pro Ser Ala Met Gly Leu Ser 85 90 95Gly Tyr Pro Glu Met Pro Asn Met Gly Gly Met Pro His Met His Met 100 105 110Gln His Met Pro Gln Gln Gln Gln His His Gln Pro Pro Pro Gln Gln 115 120 125Pro Ile Lys Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg 130 135 140Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser Gly Val Arg Pro145 150 155 160His Val Cys Asp Trp Pro Gly Cys Gly Lys Gln Phe Ile Gln Arg Ser 165 170 175Ala Leu Thr Val His Gln Arg Val His Thr Gly Glu Lys Pro His His 180 185 190Cys Glu Thr Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg 195 200 205His Arg Arg Thr His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala 210 215 220Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln225 230 235 240Asn His His Ser Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala 245 250 255Ala Leu Ala Ala Ser Lys Thr Lys Gly Met Ser Gln Ala Arg Ser Glu 260 265 270Ser Asp His Met Ser Asn His Gly Ser Pro Met Thr Thr Pro Ser Pro 275 280 285Ser Gln Arg Thr Met Ser Met Ser Pro Ser Val Asp Leu Ser Gly Thr 290 295 300Asn Ser Ile Pro Arg His Pro Gly Asp Phe Gln Tyr Leu Gln Gln Thr305 310 315 320Gly Ser Leu Pro Met His Met Arg Val Gly Ser Pro Thr Ser Thr Ser 325 330 335Ser Gly Gly Tyr Asn Met Met Arg Pro Thr Ser His Pro Thr Ser Tyr 340 345 350Gly Pro Pro Pro Thr Leu Glu Pro Asn Leu Asp Asn Ser Gln Gly Thr 355 360 365Pro Ser Ser Asn Gly Gly Ser Pro His Met Ala Asn Val Gly Trp Gln 370 375 380Ser Pro Ser His Met Ala Ser Pro Ser Gln Asn Asn Ala Ser Tyr Val385 390 395 400Tyr Pro Asp Pro Ala Asp Ala Tyr Pro Thr Asn Asn Ala Met Asn Gln 405 410 415Met Tyr Tyr Gly Ala Ala Thr His Met Arg Arg Pro Gln Ser Ala Glu 420 425 430Pro Gly Leu Val His Met Ala 435131468PRTArtificial Sequencesynthesized 131Met Asp Ile Leu Glu Leu Ile Asp Asp Arg Glu Gln Thr Val Ala Glu1 5 10 15Ser Ser Pro Arg Pro Phe Cys Cys Pro Glu Gln Ser Cys Asn Lys Ser 20 25 30Phe Asn Arg Lys Ser Asp Leu Gln Arg His His Arg Ile His Thr Asn 35 40 45Glu Arg Pro Tyr Ser Cys Thr Phe Pro Asn Cys Gly Lys Ser Phe Ile 50 55 60Gln Arg Ser Ala Leu Thr Val His Thr Arg Thr His Thr Gly Glu Lys65 70 75 80Pro His Ser Cys Glu Tyr Ile Gly Cys Gly Lys Cys Phe Ser Asp Ser 85 90 95Ser Ser Leu Ala Arg His Arg Arg Ile His Thr Gly Lys Arg Pro Tyr 100 105 110Ser Cys Pro Ile Asp Lys Cys Gly Lys Ser Phe Cys Arg Lys Thr Thr 115 120 125Leu Thr Lys His Ala Arg Lys Asn His Gln Leu Arg Ala Glu Asn Asp 130 135 140Val Ser Asp Asp Asp Val Glu Glu Ser Asp Asp Asp Asp Leu Ser Pro145 150 155 160Lys Ala Ser Gly Lys Ala Gly Ser Arg Ala Gln Ser Lys Arg Leu Thr 165 170 175Lys Ala Ser Ala Arg Arg Ala Ala Pro Pro Ser Ala Pro Ser Arg Pro 180 185 190Ser Val Leu Arg Thr Ser Ser Phe Ala Glu Pro Leu Thr Pro His Ser 195 200 205Pro Gln Ser Thr Val Arg Ser Gly His Ser Ser Arg Asn Thr Ser Phe 210 215 220Ser Ala Ala Ser Asp Ser Tyr Arg His Ser Met Pro Met Ala Met Thr225 230 235 240His Ser Val His Gln His Gln Pro Pro Thr Pro Gln Ser Pro Tyr Tyr 245 250 255Thr Glu Glu Asp Val Gly Asp Gly Arg Glu Ile Ser Pro Asn Ala Ile 260 265 270Ile His Arg Asp Asp Glu Tyr Gly Thr Thr Pro Thr Gly Pro Pro Pro 275 280 285Pro Leu Gln Gly Asn Arg Ser Phe Asp Thr Leu Ser Ile Val Cys Ser 290 295 300Thr Pro Thr Thr His Gln Leu Leu Ala Ala Gln Gln Thr Leu Gln Ser305 310 315 320Ser Pro Gly Ser Leu Ser Ser Cys Ser Ser Ala Thr Thr Ala Ser Cys 325 330 335Gly Ser Asp Tyr Phe Tyr Arg Ala Pro Gln Pro Thr Ser Ser Gly His 340 345 350Tyr Gln Asn Met Gly Gln Ala Ile Ser Pro Gly Gly Ile Pro Pro Tyr 355 360 365Pro Ala Gln Met Pro Val His Thr Gly Pro Ser Gln His Pro Ile Val 370 375 380Met Tyr Ser Gln Asn Gly Gln His Gln Ser Asn Gly Ile Leu Ser Pro385 390 395 400His Ser Gln Ala Gln Ala Gln Gln Gln Gln Gln Gln Gln Pro Val Trp 405 410 415Tyr Asp Tyr Pro Ala Tyr Gln Gln Gln Ile Leu Ala Ala Gln Thr Gln 420 425 430Pro Pro Gln His Arg Ile Tyr Tyr Thr Gly Val Pro Val Gln Asp Pro 435 440 445Asn Phe Ile Lys Thr Glu Gln Glu Gln Asn Leu Leu Pro Thr Pro Arg 450 455 460Gly Ser Phe Cys465132470PRTArtificial Sequencesynthesized 132Met Glu Leu Gly Asn Ile Leu Asn Thr Lys Phe Pro Ala Ala Ala Val1 5 10 15Leu Ala Ser Pro Phe Asn Met Gln His Ala Met Gln His Glu Leu Gln 20 25 30Gln Gln His Phe Ala Pro Thr Tyr Leu Asn Gly Arg Ile Lys Ser Glu 35 40 45Thr Gly Ser Asp Arg Gly Val Ser Pro His Pro Ser Asp Ser Ser Arg 50 55 60Tyr Ser Ser Gln Ala Pro Gln Pro Leu Gln Ser Tyr Pro Pro Pro Met65 70 75 80Ser Asn Asn Met Asn Gly Met Arg Tyr Pro Ser Pro Ser Gln Met Gln 85 90 95Thr Pro Met Pro Leu Leu Asn Asn Asn Asn Tyr Ile Pro Asn Pro Pro 100 105 110Glu His Thr Tyr Pro Gln Gln Pro Thr Pro Asp Pro Gln Gln Gln Met 115 120 125Gly Gly Arg Pro Ala Ser Asp Thr Gly Pro Pro Lys Ala Phe Ala Cys 130 135 140Ser Thr Cys Ser Lys Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His145 150 155 160Glu Arg Ile His Ser Gly Ile Arg Pro His Val Cys Asp His Pro Gly 165 170 175Cys Gly Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr Val His Gln Arg 180 185 190Val His Thr Gly Glu Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro 195 200 205Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg Ile His Ser Gly 210 215 220Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr225 230 235 240Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His Thr Gly Thr Val 245 250 255Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala Ser Arg Ala Ala 260 265 270Asn Pro Asn Arg Ser Ala Arg Ser Glu Ala Asp Glu Phe Ser Glu Thr 275 280 285Ala Ser Pro Leu Gly Thr Pro Ser Pro Asn Glu Arg Pro Leu Ser Leu 290 295 300Ser Pro Ala Ala Gly Met Pro Val Val Pro Asn Met His Arg Gln Ala305 310 315 320Ser Asp Tyr Ala Tyr Leu Gly Asn Met Asn Val Pro Pro His Leu Arg 325 330 335Asn Glu Ile Pro Gln Pro Ser Pro Arg Ser Ser Pro Ser Leu Thr Ala 340 345 350Gln Ser Tyr Asn Ser Ala Val Ser Asn Gly Arg Pro Ala Ile Thr Ser 355 360 365His Pro Ser Gly Tyr Gly Pro Pro Ser Ile Leu Glu Pro Pro Ala Ser 370 375 380Ala Thr His Asn Gln Pro Gly Ser Ala Asn Gly Ser Pro His Met Gly385 390 395 400Thr Met Gly Trp Gln Ser Pro Ser Gln Gln Ala Met Pro Ser Pro Gly 405 410 415Ala Gly Asp Ser Tyr Val Tyr Pro Glu Pro His Tyr Gln Ser Asn Gly 420 425 430Gly Asn Met Tyr Tyr Gln Asn Ala Gly Ile Gln Arg Pro Asn Ser Thr 435 440 445Glu Pro Asp Arg Tyr Asn Pro Gln Gln Gln Arg Met Thr Asn Glu Met 450 455 460Trp Ala Pro Ala Val Gln465 470133491PRTArtificial Sequencesynthesized 133Met Ala Leu Pro Glu Gln Thr Ala Ala Pro Gln Ala Trp Gly Arg Trp1 5 10 15Gln Gln Gln Pro Ala Gly His Asp Tyr Gly Met Met Asp Asn Ser Thr 20 25 30Phe Val Gln Tyr Asp Ser Arg Ala Ala Thr Ser Ala Pro Met Asn Gly 35 40 45Ala Ile Met Ala Pro Gln Tyr Met Val Ala Pro Gln Tyr Asn Met Thr 50 55 60Gln Met Pro Ala Met Gly His Gln Cys Pro Thr Gln Asn His Phe Ala65

70 75 80Tyr Thr Gln Tyr Asp Ser Ser Pro Thr Asn Met Asn Met Pro Phe Arg 85 90 95Leu Pro Pro Gln Pro Glu Arg Pro Val Met Pro Val Ala Ala Ser Glu 100 105 110His Asp Ile Pro Arg Ala Ser Ser Tyr Pro Gln Glu Ser Pro Ser Val 115 120 125Lys Asn Asp Arg His Arg Ser Pro Ser Ser Arg Ser Glu Thr Lys Met 130 135 140Ser Asn Pro Lys Thr Pro His Pro Leu Asn Thr Lys Glu Ile Lys Tyr145 150 155 160Asn Lys Pro Thr Ser Ala Asp Pro Val Asn Phe Thr Thr Ala Ile Asp 165 170 175Thr Leu Met Lys Ala Ile Gln Lys Arg Asn Asp Ser Glu Asp Ile Val 180 185 190Lys Gly Val Pro Glu Ile Glu Gln Val Val Lys Pro Glu Arg Met Leu 195 200 205Ser Leu Glu Pro Glu Ala Gly Ser Ile Ala Pro Val Gln Ala Pro Ala 210 215 220Pro Ile Ala Thr Glu Ser Thr Asp Ala Pro Lys Pro Lys Arg Tyr Ile225 230 235 240Cys Asp Val Glu Gly Cys Gly Lys Ser Phe Tyr Gln Ser Thr His Leu 245 250 255Asp Thr His Arg Arg Ala His Thr Gly Glu Lys Pro Tyr Gln Cys Asn 260 265 270Trp Pro Arg Cys Gly Arg Thr Phe Ser Gln Pro Gly Asn Leu Lys Thr 275 280 285His Met Arg Arg His Thr Gly Glu Lys Pro Phe Arg Cys Glu Gln Cys 290 295 300Ser Lys Val Phe Ala Gln Arg Gly Asn Leu Gln Thr His Met Ala Thr305 310 315 320His Thr Asn Ala Lys Pro Phe Val Cys Lys Leu Asp Asp Cys Asn Lys 325 330 335Met Phe Thr Gln Arg Gly Asn Leu Lys Asn His Gln Asn Lys Tyr His 340 345 350Glu Lys Thr Leu Met Glu Met Thr Asp Trp Ile Val Ser Ile Ser Asp 355 360 365Ile Asp Ala Leu Ser Asp Asp Gln Arg Glu Met Tyr Trp Tyr Phe Ala 370 375 380Asn Leu Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp385 390 395 400Arg Arg Val Ser Asn Arg Gly Ala Lys Ser Arg Thr Ala Pro Ser Ser 405 410 415Tyr Pro Val Lys Arg Val Pro Gly Pro Ala Ser Leu Ala Ala Tyr Ser 420 425 430Ser Lys Arg Leu Pro Pro Pro Glu Gln Tyr Met Gln Gln Gln Gln His 435 440 445His Gln His Gly Tyr Glu Val Tyr Asp Thr Asp Met Asp Gln Ser Ser 450 455 460Ser Ala Ser Ser Pro Arg Tyr Asp Gly Leu Pro Ala Thr Tyr Arg Asp465 470 475 480Arg Met Tyr Gln Gln Ser Thr His Ala Met Tyr 485 490134397PRTArtificial Sequencesynthesized 134Met Arg Leu Ser Glu Ala Asp Ala Pro Leu Glu Val Lys Ala Ala Arg1 5 10 15Pro Phe Ala Cys Thr Tyr Asp Ala Cys Gln Lys Ser Phe Ser Arg Arg 20 25 30Ser Asp Leu Val Arg His Val Arg Ile His Thr Asn Glu Arg Pro Phe 35 40 45Lys Cys Asp Phe Leu Ser Cys Gly Lys Cys Phe Ile Gln Arg Ser Ala 50 55 60Leu Thr Val His Met Arg Thr His Thr Gly Glu Arg Pro His Val Cys65 70 75 80Glu Leu Cys Gly Arg Ala Phe Ser Asp Ser Ser Ser Leu Ala Arg His 85 90 95Arg Arg Val His Thr Gly Lys Arg Pro Tyr Arg Cys Pro Phe Asn Gly 100 105 110Cys Asp Lys Thr Phe Cys Arg Lys Thr Thr Leu Ile Lys His His Lys 115 120 125Gly His Thr Glu Asp Gly Leu Leu Leu Asn Ser Pro Asp Tyr Ser Ser 130 135 140Lys Ser Ser Pro Thr Gly Asp Ser Thr Ser Ala Ser Ser Ser Ser Thr145 150 155 160Met Thr Pro Leu Ser Thr Asn Phe Ser Phe Ala Thr Tyr Ser Ser His 165 170 175Pro Glu Gln Ile Tyr Ser Ala Pro Ala Ser Ser Gln Tyr Phe Asn Ile 180 185 190Pro Ala Leu His His Ser Gln Asp Ser Asn Phe Ser Trp Gly Asn Pro 195 200 205Ser Asn Gln Phe Ser Pro Ser Pro Ser Phe Pro Arg Pro Asn Asn Thr 210 215 220Thr Ser Gly Trp Ser Ser Arg Ala Pro Leu Ser Glu Phe Pro Met Thr225 230 235 240Ser Ile Ser Pro Glu Tyr Asn Arg Phe Pro Arg Glu Thr Ala Phe Asn 245 250 255Asn Pro Pro His Ser Thr Asp Ala Thr Ser Ser Ser Arg Ser Phe Ser 260 265 270Val Ser Gln Gly Tyr Gly Ser Asn Pro Gln Asp Asn Ile Leu Pro Asp 275 280 285Ile Lys Pro Ser Phe Pro Phe Pro Pro Thr Thr Leu His Gln Ser Ala 290 295 300Pro Thr Val Tyr His Asp Thr Asn Pro Tyr Thr Ser Ser Phe Ala Asn305 310 315 320Thr Val Val Lys Glu Val Pro Asn Glu Pro Ser Tyr Ser Ser Gly Thr 325 330 335His Met Leu Asp Val Gly Arg His Thr Asn Val Ala Asp Phe Asn Asn 340 345 350Arg Glu Met Leu Pro Pro Leu Gly Asn Ile Pro Ile Gln Pro Leu Ser 355 360 365Leu Pro Arg Met Ser Asn Ile Asp Leu Ser Ser Ser Lys Leu Asn Gly 370 375 380Ile Gly Ser Tyr Trp Lys Ser Glu Ser Thr Trp Glu Gly385 390 395135468PRTArtificial Sequencesynthesized 135Met Ala Ala Val Val Ala His Gln Gln Ala Ala Leu Trp His Arg Arg1 5 10 15Leu Asp His Phe His Ile Pro Asp Val His Phe Thr Gly Met Met Pro 20 25 30Gln Tyr Glu Asn Gln Arg Thr Gly Gly Ser Ala Pro Thr Ser Arg Ser 35 40 45Phe Leu Pro Ala Thr Thr Gln Met Asp Leu Ser Leu Pro Leu Phe Ser 50 55 60Ala Asn Gly Leu Pro Thr Ser Val Pro Tyr Gln Ser Ser Gly Thr Phe65 70 75 80Ala Tyr Gly Ser Ser Val Asp Pro Tyr Asn Met Gln Gln Ser Asn Met 85 90 95Gln His Ser Tyr Ser Met Asn Tyr Thr Ser Asn Leu Ser Pro Ala Val 100 105 110Ser Tyr Ala Asp Arg Thr Glu His Gln Ser Leu Ala Asn Val His Glu 115 120 125Ala Arg His Ala Phe Ala Leu Asp Asn Ala His Leu Val Lys Ala Glu 130 135 140Ser Ala Ser Pro Ala Gln Ser Ser Pro Val Tyr Asn Asn Thr Ser Tyr145 150 155 160Thr Ser Glu Cys Lys Arg Ser Ser Ser Glu Pro Met Asp Pro Ser Asn 165 170 175Ile Asn Phe Ala Thr Asp Val Asp Thr Leu Met Lys Ala Ile Gln Ala 180 185 190Lys Gln Thr Thr Ser Thr Gln Gln Gln Glu Ala Pro Pro Lys Arg Glu 195 200 205Glu Pro Lys Val Ser Gln Lys Pro Arg Lys Arg Tyr Gln Cys His Met 210 215 220Pro Asp Cys Asn Lys Ser Phe Phe Gln Lys Thr His Leu Glu Ile His225 230 235 240Ile Arg Ala His Thr Gly Ala Lys Pro Phe Glu Cys Lys Ala Pro Gly 245 250 255Cys Gly Gln Arg Phe Ser Gln Leu Gly Asn Leu Lys Thr His Glu Arg 260 265 270Arg His Thr Gly Glu Arg Pro Tyr Ser Cys Asp Ile Cys Gly Lys Thr 275 280 285Phe Ala Gln Arg Gly Asn Val Arg Ala His Lys Ile Val His Gln Gln 290 295 300Ile Lys Pro Phe Thr Cys Arg Leu Asp Asp Cys Gly Lys Gln Phe Thr305 310 315 320Gln Leu Gly Asn Leu Lys Ser His Gln Asn Lys Phe His Ala Ser Thr 325 330 335Leu Lys Tyr Leu Thr Gln Lys Phe Ala Thr Ile Thr Pro Gly Asp Tyr 340 345 350Val Ser His Ala Asp Lys Glu Leu Trp Glu Tyr Phe Ala Ser Leu Tyr 355 360 365Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg Ile 370 375 380Ser Ala Met Ser Ser Ser Ala Ser Val His Pro Leu Ser Tyr Ser Thr385 390 395 400Met Pro Thr Ser Asn Asn Arg Ser Tyr Pro Gly Leu Tyr Asn His Asn 405 410 415Gly Ser Asp Arg Ser Ser Arg Ser Ser Ser Ala Cys Thr Asp Leu Ser 420 425 430Asn Gln Arg Pro Glu Pro Asn Tyr Asp Phe Asn Ala Pro Met Gln Ala 435 440 445Gly Tyr Pro Thr Gln Gly Thr Gly Tyr Asp Asp Met Val Phe Pro Glu 450 455 460Arg Lys Met Tyr465136452PRTArtificial Sequencesynthesized 136Met Glu Ala Ala Glu Pro Val Ser Tyr Glu Phe Pro Gly His Ala Ile1 5 10 15Gly Ala Val Ala Pro Arg Arg Met Met Asn Thr Gly Leu Gly His Thr 20 25 30Leu Pro Phe Tyr Pro Gly Pro Thr Ala Ser Phe Pro Leu Ser Phe His 35 40 45Gln Gln Ser Ser Ala Ser Tyr Gly Phe Gly His Pro Met Asn Gln His 50 55 60His His His Pro Gln Gln His His His His Gln Thr Ser Tyr Gln His65 70 75 80Tyr Phe Val Pro Gly Gln Gln Pro Leu Asn Ser Gln Pro Val Arg Leu 85 90 95Leu Ser Glu Pro Pro Ser Ile Gln Pro Ile Pro Glu Ile Arg Pro Ala 100 105 110Lys Asn Ala Val Ser Arg Met Met Lys Asp Ala Ser Ala Ser Ile Gly 115 120 125His Lys Ser Ser Val Gln Gln Pro Leu Gly Gln His Pro Thr Ser Gly 130 135 140Gly Pro Thr Gln Gly Arg Ser Pro Cys Pro Asn Glu Ile Glu Phe Ser145 150 155 160Thr Glu Val Asp Ile Leu Met Lys Ala Ile Gln Ser Lys Ala Ser Thr 165 170 175Gln Ser Ala Ile Val Gln Ser Leu Pro Pro Leu Gln Gln Met Thr His 180 185 190Gly Val Asn Pro Ser Thr Phe Ala Pro Gln Tyr Ser Ile Gln Ala Ala 195 200 205Thr Asn Pro Arg Cys Thr Val Ile Val Glu Asp Gln Pro Leu Leu Ser 210 215 220Ala Lys Lys Arg Lys Tyr Ala Cys Thr Leu Pro His Cys Gly Lys Ser225 230 235 240Phe Ala Gln Lys Thr His Leu Asp Ile His Met Arg Ala His Thr Gly 245 250 255Asp Lys Pro Phe Val Cys Lys Glu Pro Leu Cys Gly Gln Arg Phe Ser 260 265 270Gln Leu Gly Asn Leu Lys Thr His Gln Arg Arg His Thr Gly Glu Lys 275 280 285Pro Phe Ser Cys Glu Ile Cys His Lys Arg Phe Ala Gln Arg Gly Asn 290 295 300Val Arg Ala His Lys Ile Thr His Gln His Ala Lys Pro Phe Thr Cys305 310 315 320Leu Leu Asp Asp Cys Gly Lys Gln Phe Thr Gln Leu Gly Asn Leu Lys 325 330 335Ser His Gln Asn Lys Phe His Ala Ala Thr Leu Lys Ile Leu Thr Leu 340 345 350Lys Phe Ser Gln Val Thr Asp Ala Asp Asn Met Ser Ser Gln Asp Gln 355 360 365Lys Leu Trp Glu Tyr Phe Ala Thr Leu Tyr Lys Asn Ser Asn Lys Gly 370 375 380Ile Lys Gly Arg Gly Lys Asp Arg Arg Ile Ser Pro Thr Ala Arg Ser385 390 395 400Glu Thr Arg Pro Asp Thr Arg Arg Arg Leu Gln Ser Leu Thr Asn Ser 405 410 415Asp Gly Lys Gly Arg Arg Ala Ser Tyr Gly Glu Met Ser Thr Cys Asn 420 425 430Gly Ala Ser Ser Ser Asp Glu Glu Asp Ile Gly Pro Tyr Phe Leu Asp 435 440 445Arg Gln Gly His 450137479PRTArtificial Sequencesynthesized 137Met Gln Tyr Glu Val Pro Met Pro Ile Thr Met Ser His Asp Met Ser1 5 10 15Thr Ala Thr Gly His Tyr Ala His Gln Asn Leu Tyr Val Pro Asn Asn 20 25 30Asn Ala Asn Arg Ile Lys Ser Glu Thr Gly Ser Glu Arg Gly Val Ser 35 40 45Pro His Ser Asn Ser Asp His Ser Arg Tyr Ser Ser Gln Thr Pro His 50 55 60Asn Asn Ser Val Ala Tyr Gln Gln Ile Ala Ala Gln Leu Gln Asn Gly65 70 75 80Met Arg Tyr Pro Ser Pro Asn Gly Leu Gln Gln Gln Asn Gly Met Ser 85 90 95Met Leu Gln His Asn Tyr Gln Pro Ser Ala Thr Pro Glu Gln Pro Phe 100 105 110Gln Gln Gln Gln Ser Ala Ser Met Gly Ala Val Gln Gln Ala Val Ser 115 120 125Gln Pro Gln Gln Glu Gln Ser Pro Met Glu Gly Gly Arg Ala Ser Thr 130 135 140Gly Ser Thr Gly Leu Pro Lys Ala Phe Ala Cys Ser Thr Cys Gln Lys145 150 155 160Gly Phe Ala Arg Arg Ser Asp Leu Ala Arg His Glu Arg Ile His Ser 165 170 175Gly Val Arg Pro His Val Cys Asp His Pro Gly Cys Gly Lys Gln Phe 180 185 190Ile Gln Arg Ser Ala Leu Thr Val His Ser Arg Val His Thr Gly Glu 195 200 205Lys Pro His Met Cys Glu Arg Cys Gly Lys Pro Phe Ser Asp Ser Ser 210 215 220Ser Leu Ala Arg His Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys225 230 235 240Cys Pro Tyr Ala Asp Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu 245 250 255Thr Arg His Gln Asn His His Thr Gly Thr Ile Glu Glu Ser Glu Ala 260 265 270Ala Thr Ala Ala Ala Leu Ala Ser Arg Val Ser Leu Gln Asn Ser Arg 275 280 285Ser Arg Gly Ser Asp Glu Glu Asn Asp Tyr Ser Asp Gly Lys Ser Pro 290 295 300Met Pro Asn Ala Ser Glu Arg Thr Ala Thr Pro Val Asn Gly Asn Gln305 310 315 320Asn Leu Gln Arg Gln Ala Ser Asp Tyr Tyr Met Asn Ala Met Gln Gly 325 330 335Gly Met Ala Ala Val Pro Thr His Ile Arg Ala Glu Met Pro Asn Gly 340 345 350Val Pro Ser Arg Ala Ala Ser Pro Ala Gln Tyr Pro Met Pro Ala Val 355 360 365Asn Gly Gln Gln Gln Arg Pro Pro Leu Thr Ser Asn Pro Ser Ser Gly 370 375 380Tyr Asn Pro Pro Gln Ile Met Glu Pro Ser Val Gly Asn Gly Gln Gln385 390 395 400Thr Gly Ser Gly Thr Asn Ser Pro His Met Gln Gly Trp Gln Ser Pro 405 410 415His Thr Gly Val Gln Ala Gln Pro Asn Asp Tyr Ser Tyr Thr Asp Ala 420 425 430Asn Asn Asn Tyr Asn Gly Thr Asn Val Asn Val Leu Gln Gln Tyr Tyr 435 440 445Thr Thr Pro Asp Val Gln Arg Pro His Ser Thr Gly Pro Val Gly Tyr 450 455 460His Asn Gln Met Arg Gly Gln Glu Met Trp Ala Gln His Gln Gln465 470 475138468PRTArtificial Sequencesynthesized 138Met Asp Leu Thr Asn Ile Leu Asn Thr Lys Asp Ala Ala Ala Ala Ala1 5 10 15Ala Gly Ala Ala Pro Pro Leu Thr Leu Ser Leu Glu Met Gln Lys Asn 20 25 30Pro Tyr Leu Ala Asn Pro Gly Ala His Pro His Ser Pro Ala Ala Ser 35 40 45Asp Phe Ile Ser Asp Arg Glu Gly Ser Pro His Ser Ser Thr Ser Pro 50 55 60Ser Ala Ser Glu His Ser Pro Ser Ala Tyr Pro Leu Pro Ser Asn Ala65 70 75 80Leu Val Ser Ala Asn Gly Ser Tyr Ser Gly Val Pro Ser Gly Ala Val 85 90 95Asn Thr Val Pro Arg Gly Pro Gly Arg Pro Ser Ser Gly Asp Pro Tyr 100 105 110Ser Lys Ala Phe Pro Cys Ser Val Cys Ser Lys Gly Phe Ala Arg Arg 115 120 125Ser Asp Leu Ala Arg His Glu Arg Ile His Thr Gly Val Arg Pro His 130 135 140Val Cys Asp Tyr Pro Gly Cys Asp Lys Gln Phe Ile Gln Arg Ser Ala145 150 155 160Leu Thr Val His Ala Arg Val His Thr Gly Glu Lys Pro His Met Cys 165 170 175Asp Thr Cys Gly Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His 180 185 190Arg Arg Ile His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp 195 200 205Cys Gln Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn 210 215 220His His Thr Gly Thr Ile Ser Glu Ala Ala Ala Ala Thr Ala Ala Ala225 230 235 240Leu Ala

Ala Arg Pro Thr Leu Pro Lys Pro Gly Arg Pro Pro Arg Ser 245 250 255Pro Asn Ala Arg Pro Leu Gly Arg Pro Pro Asn Asp Ser Asn Pro Ser 260 265 270Ser Ala His Ser Thr Pro Ser Pro Gly Gln Arg His Ala Ser Leu Ser 275 280 285Pro Ser Thr Glu Leu Pro Pro Pro Phe Ser Ala His Arg Gln Gly Gly 290 295 300Asp Tyr His Tyr Arg Gln Ser Asn Ile Thr Ser His Pro Ser Thr Ser305 310 315 320Leu Met Asn Glu Leu Gln Pro Leu Thr Pro Arg Pro Thr Pro Thr Thr 325 330 335Thr Pro Thr Ile Ser Ser Gly Met Val Pro Ala Gly Pro Arg Gln Pro 340 345 350Pro Thr Ser Asn Pro Thr Phe Met Ser Ser Leu Pro Pro Ile Leu Glu 355 360 365Pro Pro Pro Lys Pro Asp Ala Gln Arg Gln Gly Ser Pro His Leu Ser 370 375 380Gly Ser Pro His Met Ser Ala Ala Gly Ser Pro His Met Ser His Pro385 390 395 400Ser Pro Leu Phe Ser Pro Gly Tyr Arg Ser Pro Ser Cys His Ser Thr 405 410 415Val Ser Glu Asp Thr Val Phe Phe Pro Pro His Asn Ser Phe Gln Ser 420 425 430Pro Val Leu Gly Ser His Tyr Gly Ser Asp His Leu Arg Arg Pro His 435 440 445Ser Ser Asp Ser Leu His Ser Tyr Glu Gln Arg Glu Val Arg Leu Pro 450 455 460Gly Val Tyr Pro465139492PRTArtificial Sequencesynthesized 139Met Ala Leu Thr Glu Gln Thr Ala Thr Pro Gln Ala Trp Gly Arg Trp1 5 10 15Gln Gln Gln Pro Thr Gly His Gly Tyr Ala Met Met Asp Asn Ser Thr 20 25 30Phe Val Pro Tyr Glu Ser Arg Ala Ala Thr Ser Ala Pro Met Asn Gly 35 40 45Ala Ile Met Ala Pro Gln Tyr Met Val Ala Pro Gln Tyr Asn Met Thr 50 55 60Pro Met Pro Ala Met Gly His Cys Thr Ser Gln Asn His Phe Ala Tyr65 70 75 80Ala Gln Tyr Asp Ser Pro Pro Thr Asn Met Asn Met Pro Phe Arg Leu 85 90 95Pro Ala His Gln Glu Arg Pro Val Met Pro Val Ala Ala Pro Glu His 100 105 110Asp Ile Pro Arg Ala Ser Ser Tyr Pro Gln Glu Ser Pro Ser Ser Gln 115 120 125Asn Asp Arg His Ser Ser Pro Ser Thr Arg Ser Glu Thr Lys Met Ser 130 135 140Asn Pro Lys Thr Pro His Pro Leu Asn Thr Lys Asp Ile Lys Phe Asn145 150 155 160Lys Pro Thr Ser Ala Glu Pro Val Asn Phe Thr Thr Ala Ile Asp Thr 165 170 175Leu Met Lys Ala Ile Gln Lys Arg Arg Asp Ser Glu Asp Ile Val Lys 180 185 190Gly Val Pro Glu Ile Glu Gln Leu Val Lys Pro Glu Pro Arg Ser Pro 195 200 205Lys Pro Glu Ala Gly Pro Val Thr Ser Val Pro Thr Pro Ala Pro Ala 210 215 220Ala Thr Glu Ser Thr Asp Thr Pro Lys Pro Lys Arg Tyr Val Cys Thr225 230 235 240Ile Asp Gly Cys Gly Lys Ser Phe Tyr Gln Ser Thr His Leu Asp Thr 245 250 255His Arg Arg Ala His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Trp Pro 260 265 270Arg Cys Gly Arg Thr Phe Ser Gln Pro Gly Asn Leu Lys Thr His Met 275 280 285Arg Arg His Thr Gly Glu Lys Pro Phe Arg Cys Glu Gln Cys Ser Lys 290 295 300Val Phe Ala Gln Arg Gly Asn Leu Gln Thr His Met Ala Thr His Thr305 310 315 320Asn Ala Lys Pro Phe Val Cys Lys Leu Asp Asp Cys Asn Lys Met Phe 325 330 335Thr Gln Arg Gly Asn Leu Lys Asn His Gln Asn Lys Tyr His Glu Lys 340 345 350Thr Leu Met Glu Met Thr Asp Trp Ile Val Ser Ile Ser Asp Ile Asp 355 360 365Ala Leu Ser Asp Asp Gln Arg Glu Met Tyr Trp Tyr Phe Ala Asn Leu 370 375 380Tyr Lys Asn Ser Asn Lys Gly Ile Lys Gly Arg Gly Lys Asp Arg Arg385 390 395 400Val Ser Asn Arg Gly Ser Lys Ser Arg Thr Ala Pro Ser Ser Tyr Pro 405 410 415Val Lys Arg Val Pro Gly Pro Ser Ser Leu Ala Ala Tyr Ser Ser Lys 420 425 430Arg Leu Pro Pro Pro Glu Gln Tyr Met Gln Gln Gln Gln Gln Gln Gln 435 440 445His His Gln Gln Ser Tyr Glu Val Tyr Asp Thr Asp Met Asp Gln Ser 450 455 460Ser Ser Ala Ser Ser Pro Arg Tyr Asp Gly Ile Pro Val Ala Tyr Arg465 470 475 480Asp Arg Met Tyr Gln Gln Ser Thr His Ala Met Tyr 485 490140453PRTArtificial Sequencesynthesized 140Arg Ser Asn Ala Val Met Ser Ser Ala Ser Pro Glu Val Met Asp Ile1 5 10 15Thr Asn Met Leu Asn Asn Lys Gly Gly Ala Met Thr His Gly Leu Gly 20 25 30Gly Gly Met His Asp His His Gln His Gln His His His Leu Gly Leu 35 40 45Val Lys His Glu Pro Thr Met Asp Arg Ser Gly Ser Pro His Met Ser 50 55 60Glu His Ser Ser Tyr Ser Ala His Ser Met Ser Arg Ala Tyr Pro Ser65 70 75 80Pro Thr Ala Met Gln Ala Pro Met Gln Ile Pro Asn Ser Met His Asn 85 90 95Ala Met Gln Met Gly Gly Phe Ala Asp Met Ser Gly Met Gly Gly Val 100 105 110Pro Ser Met Ala Met His His Ile Pro Gln His Pro Pro Gln Gln Gln 115 120 125Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Pro Gln Ala Pro Val Lys 130 135 140Ala Tyr Pro Cys Ser Thr Cys Gly Lys Gly Phe Ala Arg Arg Ser Asp145 150 155 160Leu Ala Arg His Glu Arg Ile His Thr Gly Val Arg Pro His Val Cys 165 170 175Asp Tyr Pro Lys Cys Asn Lys Gln Phe Ile Gln Arg Ser Ala Leu Thr 180 185 190Val His Gln Arg Val His Thr Gly Glu Lys Pro His His Cys Glu Thr 195 200 205Cys Ala Lys Pro Phe Ser Asp Ser Ser Ser Leu Ala Arg His Arg Arg 210 215 220Thr His Ser Gly Lys Arg Pro Tyr Lys Cys Pro Tyr Ala Asp Cys Gln225 230 235 240Lys Thr Phe Thr Arg Arg Thr Thr Leu Thr Arg His Gln Asn His His 245 250 255Thr Gly Thr Ile Glu Glu Ala Ala Ala Ala Thr Ala Ala Ala Leu Ala 260 265 270Ala Ser Arg Ala Lys Asn Gly Ser Gln Ala Arg Ser Asp Gly Asp His 275 280 285Met Ser Ser His Gly Ser Pro Leu Ser Thr Pro Ser Pro Ser Gln His 290 295 300Gly Met Met Ser Pro Ala Leu Asp Leu Ser Gly Ser Asn Gly Ile Pro305 310 315 320Arg His Ala Ala Asp Phe Gln Gln Tyr Ile Thr Gln Ser Gly Gly Leu 325 330 335Pro Pro His Leu Arg Val Gly Ser Pro Thr Ser Thr Thr Ser Ala Ala 340 345 350Ser Tyr Asn Thr Gly Ile Arg Pro Thr Ser His Pro Thr Gly Tyr Gly 355 360 365Pro Pro Pro Thr Leu Glu Pro Asn Leu Glu Gln His Pro Ala Gly Ser 370 375 380Gly Ser Ala Gly Gly Ser Pro His Met Ser Gln Val Ser Trp Gln Ser385 390 395 400Pro Gln Thr His Ser Pro Ser His Asn Gly Gly Ser Tyr Ile Tyr Pro 405 410 415Asp Pro Asp Gly Gly Tyr Pro Pro Asn Pro Ala Met Ser Gln Met Tyr 420 425 430Tyr Gly Ala Pro Gln Gln Met Arg Arg Pro Gln Ser Ala Glu Pro Gly 435 440 445Leu Val His Met Ala 4501411437PRTArtificial Sequencepromoter region of the glyceraldehyde-3- phosphate dehydrogenase gene (GPDp) of T. reesei 141Gly Ala Cys Gly Cys Ala Gly Ala Ala Gly Ala Ala Gly Gly Ala Ala1 5 10 15Ala Thr Cys Gly Cys Cys Cys Cys Gly Cys Cys Gly Gly Thr Thr Cys 20 25 30Cys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Thr Gly Ala 35 40 45Gly Cys Gly Cys Ala Gly Gly Gly Ala Cys Ala Ala Gly Cys Ala Cys 50 55 60Ala Gly Cys Cys Thr Thr Gly Gly Cys Cys Cys Thr Gly Gly Gly Cys65 70 75 80Cys Thr Ala Gly Cys Cys Thr Thr Gly Cys Gly Cys Cys Thr Thr Gly 85 90 95Thr Thr Thr Gly Ala Thr Gly Cys Ala Ala Thr Cys Gly Gly Cys Gly 100 105 110Ala Cys Ala Thr Gly Thr Cys Gly Ala Ala Thr Gly Cys Thr Gly Thr 115 120 125Ala Ala Thr Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Ala Gly 130 135 140Gly Thr Thr Cys Cys Cys Cys Thr Thr Thr Thr Cys Cys Thr Thr Thr145 150 155 160Thr Gly Thr Gly Thr Thr Ala Ala Thr Ala Ala Thr Ala Ala Thr Thr 165 170 175Cys Thr Cys Gly Ala Ala Gly Gly Gly Cys Gly Cys Thr Gly Ala Thr 180 185 190Thr Thr Thr Gly Ala Ala Ala Thr Thr Thr Gly Thr Cys Gly Gly Thr 195 200 205Gly Ala Gly Ala Gly Cys Cys Ala Ala Ala Cys Gly Gly Ala Thr Ala 210 215 220Thr Ala Cys Ala Gly Gly Cys Gly Cys Gly Gly Cys Thr Gly Ala Thr225 230 235 240Gly Ala Ala Thr Ala Ala Thr Gly Ala Thr Gly Ala Ala Thr Cys Gly 245 250 255Ala Gly Cys Thr Gly Ala Cys Thr Thr Gly Ala Thr Gly Cys Thr Gly 260 265 270Thr Ala Thr Gly Thr Ala Cys Ala Ala Thr Ala Thr Thr Gly Ala Cys 275 280 285Thr Gly Cys Gly Ala Gly Gly Ala Cys Cys Ala Thr Cys Ala Gly Gly 290 295 300Thr Gly Thr Thr Gly Thr Ala Thr Gly Gly Ala Thr Gly Gly Ala Ala305 310 315 320Thr Cys Ala Thr Thr Cys Thr Gly Thr Ala Ala Cys Cys Ala Cys Cys 325 330 335Ala Ala Gly Gly Thr Gly Cys Ala Thr Gly Cys Ala Thr Cys Ala Thr 340 345 350Ala Ala Gly Gly Thr Ala Thr Thr Cys Thr Cys Cys Thr Cys Ala Gly 355 360 365Cys Thr Cys Ala Cys Cys Ala Ala Cys Ala Ala Cys Gly Ala Ala Cys 370 375 380Gly Ala Thr Gly Gly Cys Cys Ala Thr Gly Thr Thr Ala Gly Thr Ala385 390 395 400Ala Ala Gly Gly Cys Ala Cys Cys Gly Thr Gly Ala Thr Gly Gly Cys 405 410 415Ala Ala Gly Ala Thr Ala Gly Ala Ala Cys Cys Ala Cys Thr Ala Thr 420 425 430Thr Gly Cys Ala Thr Cys Thr Gly Cys Gly Cys Thr Thr Cys Cys Cys 435 440 445Ala Cys Gly Cys Ala Cys Ala Gly Thr Ala Cys Gly Thr Cys Ala Ala 450 455 460Thr Gly Thr Ala Ala Cys Gly Thr Cys Ala Ala Ala Gly Cys Cys Gly465 470 475 480Cys Cys Cys Thr Cys Cys Cys Gly Thr Ala Ala Cys Cys Thr Cys Gly 485 490 495Cys Cys Cys Gly Thr Thr Gly Thr Thr Gly Cys Thr Cys Cys Cys Cys 500 505 510Cys Cys Gly Ala Thr Thr Gly Cys Cys Thr Cys Ala Ala Thr Cys Ala 515 520 525Cys Ala Thr Ala Gly Thr Ala Cys Cys Thr Ala Cys Cys Thr Ala Thr 530 535 540Gly Cys Ala Thr Thr Ala Thr Gly Gly Cys Gly Cys Cys Thr Cys Ala545 550 555 560Ala Cys Cys Cys Ala Cys Cys Cys Cys Cys Cys Cys Ala Gly Ala Thr 565 570 575Thr Gly Ala Gly Ala Gly Cys Thr Ala Cys Cys Thr Thr Ala Cys Ala 580 585 590Thr Cys Ala Ala Thr Ala Thr Gly Gly Cys Cys Ala Gly Cys Ala Cys 595 600 605Cys Thr Cys Thr Thr Cys Gly Gly Cys Gly Ala Thr Ala Cys Ala Thr 610 615 620Ala Cys Thr Cys Gly Cys Cys Ala Cys Cys Cys Cys Ala Gly Cys Cys625 630 635 640Gly Gly Gly Gly Cys Gly Ala Thr Thr Gly Thr Gly Thr Gly Thr Ala 645 650 655Cys Thr Ala Gly Gly Thr Ala Gly Gly Cys Thr Cys Gly Thr Ala Cys 660 665 670Thr Ala Thr Ala Cys Cys Ala Gly Cys Ala Gly Gly Ala Gly Ala Gly 675 680 685Gly Thr Gly Cys Thr Gly Cys Thr Thr Gly Gly Cys Ala Ala Thr Cys 690 695 700Gly Thr Gly Cys Thr Cys Ala Gly Cys Thr Gly Thr Thr Ala Gly Gly705 710 715 720Thr Thr Gly Thr Ala Cys Thr Thr Gly Thr Ala Thr Gly Gly Thr Ala 725 730 735Cys Thr Thr Gly Thr Ala Ala Gly Gly Thr Gly Gly Thr Cys Ala Thr 740 745 750Gly Cys Ala Gly Thr Thr Gly Cys Thr Ala Ala Gly Gly Thr Ala Cys 755 760 765Cys Thr Ala Gly Gly Gly Ala Gly Gly Gly Ala Thr Thr Cys Ala Ala 770 775 780Cys Gly Ala Gly Cys Cys Cys Thr Gly Cys Thr Thr Cys Cys Ala Ala785 790 795 800Thr Gly Thr Cys Cys Ala Thr Cys Thr Gly Gly Ala Thr Ala Gly Gly 805 810 815Ala Thr Gly Gly Cys Gly Gly Cys Thr Gly Gly Cys Gly Gly Gly Gly 820 825 830Cys Cys Gly Ala Ala Gly Cys Thr Gly Gly Gly Ala Ala Cys Thr Cys 835 840 845Gly Cys Cys Ala Ala Cys Ala Gly Thr Cys Ala Thr Ala Thr Gly Thr 850 855 860Ala Ala Thr Ala Gly Cys Thr Cys Ala Ala Gly Thr Thr Gly Ala Thr865 870 875 880Gly Ala Thr Ala Cys Cys Gly Thr Thr Thr Thr Gly Cys Cys Ala Gly 885 890 895Gly Ala Thr Thr Ala Gly Gly Ala Thr Gly Cys Gly Ala Gly Ala Ala 900 905 910Gly Cys Ala Gly Cys Ala Thr Gly Ala Ala Thr Gly Thr Cys Gly Cys 915 920 925Thr Cys Ala Thr Cys Cys Gly Ala Thr Gly Cys Cys Gly Cys Ala Thr 930 935 940Cys Ala Cys Cys Gly Thr Thr Gly Thr Gly Thr Cys Ala Gly Ala Ala945 950 955 960Ala Cys Gly Ala Cys Cys Ala Ala Gly Cys Thr Ala Ala Gly Cys Ala 965 970 975Ala Cys Thr Ala Ala Gly Gly Thr Ala Cys Cys Thr Thr Ala Cys Cys 980 985 990Gly Thr Cys Cys Ala Cys Thr Ala Thr Cys Thr Cys Ala Gly Gly Thr 995 1000 1005Ala Ala Cys Cys Ala Gly Gly Thr Ala Cys Thr Ala Cys Cys Ala 1010 1015 1020Gly Cys Thr Ala Cys Cys Cys Thr Ala Cys Cys Thr Gly Cys Cys 1025 1030 1035Gly Thr Gly Cys Cys Thr Ala Cys Cys Thr Gly Cys Thr Thr Thr 1040 1045 1050Ala Gly Thr Ala Thr Thr Ala Ala Thr Cys Thr Thr Thr Cys Cys 1055 1060 1065Ala Cys Cys Thr Cys Cys Cys Thr Cys Cys Thr Cys Ala Ala Thr 1070 1075 1080Cys Thr Thr Cys Thr Thr Thr Thr Cys Cys Cys Thr Cys Cys Thr 1085 1090 1095Cys Thr Cys Cys Thr Cys Thr Thr Thr Thr Thr Thr Thr Thr Thr 1100 1105 1110Thr Cys Thr Thr Cys Cys Thr Cys Cys Thr Cys Thr Thr Cys Thr 1115 1120 1125Thr Cys Thr Cys Cys Ala Thr Ala Ala Cys Cys Ala Thr Thr Cys 1130 1135 1140Cys Thr Ala Ala Cys Ala Ala Cys Ala Thr Cys Gly Ala Cys Ala 1145 1150 1155Thr Thr Cys Thr Cys Thr Cys Cys Thr Ala Ala Thr Cys Ala Cys 1160 1165 1170Cys Ala Gly Cys Cys Thr Cys Gly Cys Ala Ala Ala Thr Cys Cys 1175 1180 1185Thr Cys Ala Gly Gly Thr Thr Ala Gly Thr Ala Thr Thr Ala Cys 1190 1195 1200Thr Ala Cys Thr Ala Cys Thr Ala Cys Ala Ala Thr Cys Ala Thr 1205 1210 1215Cys Ala Cys Cys Ala Cys Gly Ala Thr Gly Cys Thr Cys Cys Gly 1220 1225 1230Cys Cys Cys Gly Ala Cys Gly Ala Thr Gly Cys Gly Gly Cys Thr 1235 1240 1245Thr Cys Thr Gly Thr Thr Cys Gly Cys Cys Thr Gly Cys Cys Cys 1250 1255 1260Cys Thr Cys Cys Thr Cys Thr Cys Ala Cys Thr Cys Gly Thr Gly 1265

1270 1275Cys Cys Cys Thr Thr Gly Ala Cys Gly Ala Gly Cys Thr Ala Cys 1280 1285 1290Cys Cys Cys Gly Cys Cys Ala Gly Ala Cys Thr Cys Thr Cys Cys 1295 1300 1305Thr Gly Cys Gly Thr Cys Ala Cys Cys Ala Ala Thr Thr Thr Thr 1310 1315 1320Thr Thr Thr Cys Cys Cys Thr Ala Thr Thr Thr Ala Cys Cys Cys 1325 1330 1335Cys Thr Cys Cys Thr Cys Cys Cys Thr Cys Thr Cys Thr Cys Cys 1340 1345 1350Cys Thr Cys Thr Cys Gly Thr Thr Thr Cys Thr Thr Cys Cys Thr 1355 1360 1365Ala Ala Cys Ala Ala Ala Cys Ala Ala Cys Cys Ala Cys Cys Ala 1370 1375 1380Cys Cys Ala Ala Ala Ala Thr Cys Thr Cys Thr Thr Thr Gly Gly 1385 1390 1395Ala Ala Gly Cys Thr Cys Ala Cys Gly Ala Cys Thr Cys Ala Cys 1400 1405 1410Gly Cys Ala Ala Gly Cys Thr Cys Ala Ala Thr Thr Cys Gly Cys 1415 1420 1425Ala Gly Ala Thr Ala Cys Ala Ala Ala 1430 1435142909PRTArtificial Sequenceterminator region of the glyceraldehyde-3- phosphate dehydrogenase gene (GPDt) of T. reesei 142Gly Thr Gly Cys Thr Gly Thr Gly Thr Thr Cys Cys Thr Cys Ala Gly1 5 10 15Ala Ala Thr Gly Gly Gly Cys Cys Cys Cys Ala Gly Ala Ala Gly Gly 20 25 30Gly Cys Gly Thr Cys Gly Ala Gly Cys Ala Thr Thr Gly Thr Cys Thr 35 40 45Ala Thr Gly Ala Ala Thr Gly Cys Ala Ala Ala Cys Ala Ala Ala Ala 50 55 60Ala Thr Ala Gly Thr Ala Ala Ala Thr Ala Ala Ala Thr Ala Gly Thr65 70 75 80Ala Ala Thr Thr Cys Thr Gly Gly Cys Cys Ala Thr Gly Ala Cys Gly 85 90 95Ala Ala Thr Ala Gly Ala Gly Cys Cys Ala Ala Thr Cys Thr Gly Cys 100 105 110Thr Cys Cys Ala Cys Thr Thr Gly Ala Cys Thr Ala Thr Cys Cys Thr 115 120 125Thr Gly Thr Gly Ala Cys Thr Gly Thr Ala Thr Cys Gly Thr Ala Thr 130 135 140Gly Thr Cys Gly Ala Ala Cys Cys Cys Thr Thr Gly Ala Cys Thr Gly145 150 155 160Cys Cys Cys Ala Thr Thr Cys Ala Ala Ala Cys Ala Ala Thr Thr Gly 165 170 175Thr Ala Ala Ala Gly Gly Ala Ala Thr Ala Thr Gly Ala Gly Cys Thr 180 185 190Ala Cys Ala Ala Gly Thr Thr Ala Thr Gly Thr Cys Thr Cys Ala Cys 195 200 205Gly Thr Thr Thr Gly Cys Gly Thr Gly Cys Gly Ala Gly Cys Cys Cys 210 215 220Gly Thr Thr Thr Gly Thr Ala Cys Gly Thr Thr Ala Thr Thr Thr Thr225 230 235 240Gly Ala Gly Ala Ala Ala Gly Cys Gly Thr Thr Gly Cys Cys Ala Thr 245 250 255Cys Ala Cys Ala Thr Gly Cys Thr Cys Ala Cys Ala Gly Thr Cys Ala 260 265 270Cys Thr Thr Gly Gly Cys Thr Thr Ala Cys Gly Ala Thr Cys Ala Thr 275 280 285Gly Thr Thr Thr Gly Cys Gly Ala Thr Cys Thr Thr Thr Cys Gly Gly 290 295 300Thr Ala Ala Gly Ala Ala Thr Ala Cys Ala Cys Ala Gly Ala Gly Thr305 310 315 320Ala Ala Cys Gly Ala Thr Thr Ala Thr Ala Cys Ala Thr Cys Cys Ala 325 330 335Thr Cys Gly Cys Thr Thr Thr Cys Thr Ala Thr Gly Ala Thr Thr Ala 340 345 350Gly Gly Thr Ala Cys Thr Cys Ala Gly Ala Cys Ala Ala Cys Ala Cys 355 360 365Ala Thr Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Ala Thr Ala Ala 370 375 380Cys Cys Ala Thr Cys Gly Cys Ala Thr Gly Cys Ala Ala Gly Gly Thr385 390 395 400Cys Gly Ala Thr Thr Cys Cys Ala Ala Thr Cys Ala Thr Gly Ala Thr 405 410 415Cys Thr Gly Gly Ala Cys Thr Gly Gly Gly Gly Thr Ala Thr Thr Cys 420 425 430Cys Ala Thr Cys Thr Ala Ala Gly Cys Cys Ala Thr Ala Gly Thr Ala 435 440 445Cys Cys Cys Thr Cys Gly Ala Gly Ala Gly Ala Ala Gly Gly Ala Ala 450 455 460Thr Gly Gly Thr Ala Gly Gly Ala Cys Cys Thr Cys Thr Cys Ala Gly465 470 475 480Gly Cys Gly Thr Cys Cys Ala Cys Cys Ala Thr Cys Thr Gly Thr Gly 485 490 495Cys Thr Gly Cys Ala Ala Ala Thr Cys Cys Ala Ala Gly Ala Ala Ala 500 505 510Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Gly Cys Ala Cys Cys Thr 515 520 525Ala Cys Cys Thr Ala Thr Cys Thr Ala Cys Cys Thr Ala Gly Ala Gly 530 535 540Thr Ala Ala Thr Cys Thr Gly Cys Ala Cys Gly Ala Gly Ala Ala Ala545 550 555 560Ala Gly Ala Ala Ala Ala Gly Gly Ala Gly Cys Ala Gly Ala Ala Gly 565 570 575Ala Ala Gly Ala Ala Thr Gly Ala Thr Cys Thr Cys Ala Ala Gly Ala 580 585 590Gly Gly Cys Cys Gly Thr Gly Ala Ala Cys Gly Cys Ala Gly Ala Ala 595 600 605Ala Cys Ala Cys Ala Cys Thr Cys Cys Thr Cys Cys Cys Ala Ala Cys 610 615 620Thr Thr Thr Thr Cys Ala Ala Gly Thr Thr Thr Thr Gly Ala Ala Cys625 630 635 640Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Ala Gly Ala Thr Gly Ala 645 650 655Gly Gly Ala Cys Thr Ala Gly Ala Ala Gly Ala Thr Gly Gly Ala Gly 660 665 670Thr Ala Thr Thr Thr Cys Cys Thr Thr Cys Thr Thr Ala Gly Ala Gly 675 680 685Ala Gly Cys Thr Cys Thr Cys Gly Gly Thr Gly Ala Gly Gly Thr Gly 690 695 700Ala Cys Cys Thr Gly Thr Cys Ala Gly Gly Gly Thr Thr Thr Ala Cys705 710 715 720Cys Thr Cys Ala Ala Ala Cys Cys Gly Thr Cys Thr Gly Thr Gly Gly 725 730 735Thr Thr Cys Thr Ala Thr Cys Cys Ala Ala Thr Thr Ala Ala Thr Cys 740 745 750Ala Ala Gly Thr Cys Cys Cys Thr Cys Thr Cys Cys Thr Cys Thr Cys 755 760 765Cys Thr Cys Thr Thr Cys Thr Cys Thr Cys Cys Thr Gly Thr Cys Cys 770 775 780Thr Thr Thr Cys Ala Thr Ala Gly Ala Ala Thr Cys Cys Cys Thr Thr785 790 795 800Thr Thr Cys Cys Thr Thr Gly Thr Thr Gly Cys Thr Thr Gly Ala Thr 805 810 815Cys Gly Ala Ala Gly Cys Gly Gly Gly Thr Thr Ala Thr Cys Gly Ala 820 825 830Cys Gly Cys Cys Ala Cys Cys Ala Ala Ala Gly Thr Ala Thr Thr Gly 835 840 845Thr Cys Thr Thr Gly Gly Thr Gly Ala Cys Thr Thr Ala Thr Cys Ala 850 855 860Ala Ala Thr Cys Cys Cys Thr Thr Thr Gly Gly Thr Gly Ala Thr Cys865 870 875 880Ala Ala Ala Cys Ala Gly Cys Cys Cys Cys Cys Gly Ala Gly Thr Gly 885 890 895Ala Thr Cys Ala Gly Ala Thr Cys Cys Gly Thr Ala Ala 900 9051432603PRTArtificial SequenceHygroR cassette 143Cys Ala Ala Gly Thr Gly Thr Ala Cys Cys Thr Gly Thr Gly Cys Ala1 5 10 15Thr Thr Cys Thr Gly Gly Gly Thr Ala Ala Ala Cys Gly Ala Cys Thr 20 25 30Cys Ala Thr Ala Gly Gly Ala Gly Ala Gly Thr Thr Gly Thr Ala Ala 35 40 45Ala Ala Ala Ala Gly Thr Thr Thr Cys Gly Gly Cys Cys Gly Gly Cys 50 55 60Gly Thr Ala Thr Thr Gly Gly Gly Thr Gly Thr Thr Ala Cys Gly Gly65 70 75 80Ala Gly Cys Ala Thr Thr Cys Ala Cys Thr Ala Gly Gly Cys Ala Ala 85 90 95Cys Cys Ala Thr Gly Cys Ala Thr Cys Cys Thr Thr Ala Cys Thr Ala 100 105 110Thr Thr Gly Thr Ala Thr Ala Cys Cys Ala Thr Cys Thr Thr Ala Gly 115 120 125Thr Ala Gly Gly Ala Ala Thr Gly Ala Thr Thr Thr Cys Gly Ala Gly 130 135 140Gly Thr Thr Thr Ala Thr Ala Cys Cys Thr Ala Cys Gly Ala Thr Gly145 150 155 160Ala Ala Thr Gly Thr Gly Thr Gly Thr Cys Cys Thr Gly Thr Ala Gly 165 170 175Gly Cys Thr Thr Gly Ala Gly Ala Gly Thr Thr Cys Ala Ala Gly Gly 180 185 190Ala Ala Gly Ala Ala Ala Cys Ala Thr Gly Cys Ala Ala Thr Thr Ala 195 200 205Thr Cys Thr Thr Thr Gly Cys Gly Ala Ala Cys Cys Cys Ala Gly Gly 210 215 220Gly Cys Thr Gly Gly Thr Gly Ala Cys Gly Gly Ala Ala Thr Thr Thr225 230 235 240Thr Cys Ala Thr Ala Gly Thr Cys Ala Ala Gly Cys Thr Ala Thr Cys 245 250 255Ala Gly Ala Gly Thr Ala Ala Ala Gly Ala Ala Gly Ala Gly Gly Ala 260 265 270Gly Cys Ala Thr Gly Thr Cys Ala Ala Ala Gly Thr Ala Cys Ala Ala 275 280 285Thr Thr Ala Gly Ala Gly Ala Cys Ala Ala Ala Thr Ala Thr Ala Thr 290 295 300Ala Gly Thr Cys Gly Cys Gly Thr Gly Gly Ala Gly Cys Cys Ala Ala305 310 315 320Gly Ala Gly Cys Gly Gly Ala Thr Thr Cys Cys Thr Cys Ala Gly Thr 325 330 335Cys Thr Cys Gly Thr Ala Gly Gly Thr Cys Thr Cys Thr Thr Gly Ala 340 345 350Cys Gly Ala Cys Cys Gly Thr Thr Gly Ala Thr Cys Thr Gly Cys Thr 355 360 365Thr Gly Ala Thr Cys Thr Cys Gly Thr Cys Thr Cys Cys Cys Gly Ala 370 375 380Ala Ala Ala Thr Gly Ala Ala Ala Ala Thr Ala Gly Cys Thr Cys Thr385 390 395 400Gly Cys Thr Ala Ala Gly Cys Thr Ala Thr Thr Cys Thr Thr Cys Thr 405 410 415Cys Thr Thr Cys Gly Cys Cys Gly Gly Ala Gly Cys Cys Thr Gly Ala 420 425 430Ala Gly Gly Cys Gly Thr Thr Ala Cys Thr Ala Gly Gly Thr Thr Gly 435 440 445Cys Ala Gly Thr Cys Ala Ala Thr Gly Cys Ala Thr Thr Ala Ala Thr 450 455 460Gly Cys Ala Thr Thr Gly Cys Ala Gly Ala Thr Gly Ala Gly Cys Thr465 470 475 480Gly Thr Ala Thr Cys Thr Gly Gly Ala Ala Gly Ala Gly Gly Thr Ala 485 490 495Ala Ala Cys Cys Cys Gly Ala Ala Ala Ala Cys Gly Cys Gly Thr Thr 500 505 510Thr Thr Ala Thr Thr Cys Thr Thr Gly Thr Thr Gly Ala Cys Ala Thr 515 520 525Gly Gly Ala Gly Cys Thr Ala Thr Thr Ala Ala Ala Thr Cys Ala Cys 530 535 540Thr Ala Gly Ala Ala Gly Gly Cys Ala Cys Thr Cys Thr Thr Thr Gly545 550 555 560Cys Thr Gly Cys Thr Thr Gly Gly Ala Cys Ala Ala Ala Thr Gly Ala 565 570 575Ala Cys Gly Thr Ala Thr Cys Thr Thr Ala Thr Cys Gly Ala Gly Ala 580 585 590Thr Cys Cys Thr Gly Ala Ala Cys Ala Cys Cys Ala Thr Thr Thr Gly 595 600 605Thr Cys Thr Cys Ala Ala Cys Thr Cys Cys Gly Gly Cys Thr Ala Gly 610 615 620Cys Gly Ala Ala Thr Thr Cys Thr Cys Gly Ala Cys Thr Cys Ala Thr625 630 635 640Thr Cys Cys Thr Thr Thr Gly Cys Cys Cys Thr Cys Gly Gly Ala Cys 645 650 655Gly Ala Gly Thr Gly Cys Thr Gly Gly Gly Gly Cys Gly Thr Cys Gly 660 665 670Gly Thr Thr Thr Cys Cys Ala Cys Thr Ala Thr Cys Gly Gly Cys Gly 675 680 685Ala Gly Thr Ala Cys Thr Thr Cys Thr Ala Cys Ala Cys Ala Gly Cys 690 695 700Cys Ala Thr Cys Gly Gly Thr Cys Cys Ala Gly Ala Cys Gly Gly Cys705 710 715 720Cys Gly Cys Gly Cys Thr Thr Cys Thr Gly Cys Gly Gly Gly Cys Gly 725 730 735Ala Thr Thr Thr Gly Thr Gly Thr Ala Cys Gly Cys Cys Cys Gly Ala 740 745 750Cys Ala Gly Thr Cys Cys Cys Gly Gly Cys Thr Cys Cys Gly Gly Ala 755 760 765Thr Cys Gly Gly Ala Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly 770 775 780Cys Ala Thr Cys Gly Ala Cys Cys Cys Thr Gly Cys Gly Cys Cys Cys785 790 795 800Ala Ala Gly Cys Thr Gly Cys Ala Thr Cys Ala Thr Cys Gly Ala Ala 805 810 815Ala Thr Thr Gly Cys Cys Gly Thr Cys Ala Ala Cys Cys Ala Ala Gly 820 825 830Cys Thr Cys Thr Gly Ala Thr Ala Gly Ala Gly Thr Thr Gly Gly Thr 835 840 845Cys Ala Ala Gly Ala Cys Cys Ala Ala Thr Gly Cys Gly Gly Ala Gly 850 855 860Cys Ala Thr Ala Thr Ala Cys Gly Cys Cys Cys Gly Gly Ala Gly Thr865 870 875 880Cys Gly Thr Gly Gly Cys Gly Ala Thr Cys Cys Thr Gly Cys Ala Ala 885 890 895Gly Cys Thr Cys Cys Gly Gly Ala Thr Gly Cys Cys Thr Cys Cys Gly 900 905 910Cys Thr Cys Gly Ala Ala Gly Thr Ala Gly Cys Gly Cys Gly Thr Cys 915 920 925Thr Gly Cys Thr Gly Cys Thr Cys Cys Ala Thr Ala Cys Ala Ala Gly 930 935 940Cys Cys Ala Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Cys Cys Ala945 950 955 960Gly Ala Ala Gly Ala Ala Gly Ala Thr Gly Thr Thr Gly Gly Cys Gly 965 970 975Ala Cys Cys Thr Cys Gly Thr Ala Thr Thr Gly Gly Gly Ala Ala Thr 980 985 990Cys Cys Cys Cys Gly Ala Ala Cys Ala Thr Cys Gly Cys Cys Thr Cys 995 1000 1005Gly Cys Thr Cys Cys Ala Gly Thr Cys Ala Ala Thr Gly Ala Cys 1010 1015 1020Cys Gly Cys Thr Gly Thr Thr Ala Thr Gly Cys Gly Gly Cys Cys 1025 1030 1035Ala Thr Thr Gly Thr Cys Cys Gly Thr Cys Ala Gly Gly Ala Cys 1040 1045 1050Ala Thr Thr Gly Thr Thr Gly Gly Ala Gly Cys Cys Gly Ala Ala 1055 1060 1065Ala Thr Cys Cys Gly Cys Gly Thr Gly Cys Ala Cys Gly Ala Gly 1070 1075 1080Gly Thr Gly Cys Cys Gly Gly Ala Cys Thr Thr Cys Gly Gly Gly 1085 1090 1095Gly Cys Ala Gly Thr Cys Cys Thr Cys Gly Gly Cys Cys Cys Ala 1100 1105 1110Ala Ala Gly Cys Ala Thr Cys Ala Gly Cys Thr Cys Ala Thr Cys 1115 1120 1125Gly Ala Gly Ala Gly Cys Cys Thr Gly Cys Gly Cys Gly Ala Cys 1130 1135 1140Gly Gly Ala Cys Gly Cys Ala Cys Thr Gly Ala Cys Gly Gly Thr 1145 1150 1155Gly Thr Cys Gly Thr Cys Cys Ala Thr Cys Ala Cys Ala Gly Thr 1160 1165 1170Thr Thr Gly Cys Cys Ala Gly Thr Gly Ala Thr Ala Cys Ala Cys 1175 1180 1185Ala Thr Gly Gly Gly Gly Ala Thr Cys Ala Gly Cys Ala Ala Thr 1190 1195 1200Cys Gly Cys Gly Cys Ala Thr Ala Thr Gly Ala Ala Ala Thr Cys 1205 1210 1215Ala Cys Gly Cys Cys Ala Thr Gly Thr Ala Gly Thr Gly Thr Ala 1220 1225 1230Thr Thr Gly Ala Cys Cys Gly Ala Thr Thr Cys Cys Thr Thr Gly 1235 1240 1245Cys Gly Gly Thr Cys Cys Gly Ala Ala Thr Gly Gly Gly Cys Cys 1250 1255 1260Gly Ala Ala Cys Cys Cys Gly Cys Thr Cys Gly Thr Cys Thr Gly 1265 1270 1275Gly Cys Thr Ala Ala Gly Ala Thr Cys Gly Gly Cys Cys Gly Cys 1280 1285 1290Ala Gly Cys Gly Ala Thr Cys Gly Cys Ala Thr Cys Cys Ala Thr 1295 1300 1305Ala Gly Cys Cys Thr Cys Cys Gly Cys Gly Ala Cys Cys Gly Gly 1310 1315 1320Thr Thr Gly Thr Ala Gly Ala Ala Cys Ala Gly Cys Gly Gly Gly 1325 1330 1335Cys Ala Gly Thr Thr Cys Gly Gly Thr Thr Thr Cys Ala Gly Gly 1340 1345 1350Cys Ala Gly Gly Thr Cys Thr Thr Gly Cys Ala Ala Cys Gly Thr 1355 1360 1365Gly Ala Cys Ala Cys

Cys Cys Thr Gly Thr Gly Cys Ala Cys Gly 1370 1375 1380Gly Cys Gly Gly Gly Ala Gly Ala Thr Gly Cys Ala Ala Thr Ala 1385 1390 1395Gly Gly Thr Cys Ala Gly Gly Cys Thr Cys Thr Cys Gly Cys Thr 1400 1405 1410Ala Ala Ala Cys Thr Cys Cys Cys Cys Ala Ala Thr Gly Thr Cys 1415 1420 1425Ala Ala Gly Cys Ala Cys Thr Thr Cys Cys Gly Gly Ala Ala Thr 1430 1435 1440Cys Gly Gly Gly Ala Gly Cys Gly Cys Gly Gly Cys Cys Gly Ala 1445 1450 1455Thr Gly Cys Ala Ala Ala Gly Thr Gly Cys Cys Gly Ala Thr Ala 1460 1465 1470Ala Ala Cys Ala Thr Ala Ala Cys Gly Ala Thr Cys Thr Thr Thr 1475 1480 1485Gly Thr Ala Gly Ala Ala Ala Cys Cys Ala Thr Cys Gly Gly Cys 1490 1495 1500Gly Cys Ala Gly Cys Thr Ala Thr Thr Thr Ala Cys Cys Cys Gly 1505 1510 1515Cys Ala Gly Gly Ala Cys Ala Thr Ala Thr Cys Cys Ala Cys Gly 1520 1525 1530Cys Cys Cys Thr Cys Cys Thr Ala Cys Ala Thr Cys Gly Ala Ala 1535 1540 1545Gly Cys Thr Gly Ala Ala Ala Gly Cys Ala Cys Gly Ala Gly Ala 1550 1555 1560Thr Thr Cys Thr Thr Cys Gly Cys Cys Cys Thr Cys Cys Gly Ala 1565 1570 1575Gly Ala Gly Cys Thr Gly Cys Ala Thr Cys Ala Gly Gly Thr Cys 1580 1585 1590Gly Gly Ala Gly Ala Cys Gly Cys Thr Gly Thr Cys Gly Ala Ala 1595 1600 1605Cys Thr Thr Thr Thr Cys Gly Ala Thr Cys Ala Gly Ala Ala Ala 1610 1615 1620Cys Thr Thr Cys Thr Cys Gly Ala Cys Ala Gly Ala Cys Gly Thr 1625 1630 1635Cys Gly Cys Gly Gly Thr Gly Ala Gly Thr Thr Cys Ala Gly Gly 1640 1645 1650Cys Thr Thr Thr Thr Thr Cys Ala Thr Gly Ala Thr Gly Gly Cys 1655 1660 1665Cys Cys Thr Cys Cys Thr Ala Cys Cys Gly Gly Thr Gly Ala Thr 1670 1675 1680Cys Thr Cys Ala Gly Cys Thr Gly Thr Ala Gly Gly Ala Ala Ala 1685 1690 1695Gly Ala Gly Ala Ala Gly Ala Ala Gly Gly Thr Thr Ala Gly Thr 1700 1705 1710Ala Gly Thr Cys Gly Ala Cys Ala Thr Gly Gly Thr Gly Gly Cys 1715 1720 1725Cys Cys Thr Cys Cys Thr Ala Thr Ala Gly Thr Gly Ala Gly Thr 1730 1735 1740Cys Gly Thr Ala Thr Thr Ala Thr Ala Cys Thr Ala Thr Gly Cys 1745 1750 1755Cys Gly Ala Thr Ala Thr Ala Cys Thr Ala Thr Gly Cys Cys Gly 1760 1765 1770Ala Thr Gly Ala Thr Thr Ala Ala Thr Thr Gly Thr Cys Ala Ala 1775 1780 1785Cys Ala Cys Thr Ala Gly Gly Cys Gly Cys Cys Gly Gly Thr Cys 1790 1795 1800Ala Cys Ala Ala Cys Thr Ala Gly Thr Ala Gly Ala Thr Ala Thr 1805 1810 1815Cys Ala Cys Thr Thr Ala Cys Gly Thr Gly Thr Thr Gly Ala Gly 1820 1825 1830Ala Gly Gly Cys Gly Gly Cys Ala Thr Gly Cys Gly Ala Thr Ala 1835 1840 1845Ala Gly Ala Gly Gly Thr Gly Thr Ala Ala Thr Thr Ala Cys Cys 1850 1855 1860Thr Gly Ala Gly Ala Ala Cys Ala Thr Cys Thr Thr Gly Thr Thr 1865 1870 1875Gly Cys Cys Cys Thr Gly Cys Thr Thr Thr Cys Cys Gly Thr Gly 1880 1885 1890Cys Gly Ala Ala Ala Thr Ala Cys Thr Ala Cys Cys Gly Gly Thr 1895 1900 1905Ala Cys Thr Thr Thr Thr Gly Gly Gly Ala Ala Ala Cys Ala Ala 1910 1915 1920Gly Gly Gly Ala Ala Cys Ala Gly Gly Ala Gly Gly Gly Cys Gly 1925 1930 1935Cys Thr Gly Cys Thr Gly Thr Gly Cys Gly Cys Gly Gly Thr Thr 1940 1945 1950Cys Thr Gly Ala Gly Thr Gly Thr Thr Cys Ala Gly Gly Ala Thr 1955 1960 1965Thr Gly Ala Ala Gly Cys Thr Gly Ala Ala Gly Ala Ala Gly Gly 1970 1975 1980Thr Gly Cys Thr Gly Ala Gly Gly Ala Ala Gly Cys Gly Thr Ala 1985 1990 1995Gly Ala Ala Cys Thr Gly Thr Thr Gly Cys Gly Gly Ala Cys Gly 2000 2005 2010Cys Gly Ala Gly Thr Thr Cys Thr Gly Ala Gly Ala Ala Gly Ala 2015 2020 2025Gly Cys Thr Gly Thr Ala Cys Cys Gly Ala Thr Thr Gly Gly Thr 2030 2035 2040Gly Ala Ala Ala Gly Cys Cys Gly Ala Ala Gly Ala Ala Gly Thr 2045 2050 2055Gly Ala Gly Thr Thr Gly Gly Thr Gly Cys Cys Cys Thr Gly Thr 2060 2065 2070Thr Gly Cys Cys Thr Gly Gly Ala Thr Ala Ala Thr Gly Thr Thr 2075 2080 2085Thr Gly Cys Ala Ala Cys Thr Cys Gly Cys Thr Gly Gly Thr Thr 2090 2095 2100Cys Thr Gly Cys Ala Gly Ala Gly Ala Cys Gly Gly Ala Gly Ala 2105 2110 2115Cys Ala Ala Ala Thr Gly Cys Thr Gly Gly Cys Thr Ala Cys Gly 2120 2125 2130Ala Thr Gly Thr Thr Gly Cys Thr Gly Ala Thr Thr Cys Ala Gly 2135 2140 2145Gly Thr Thr Gly Ala Thr Ala Cys Cys Thr Cys Gly Gly Thr Cys 2150 2155 2160Gly Ala Gly Ala Cys Ala Cys Thr Gly Thr Thr Thr Thr Gly Gly 2165 2170 2175Thr Thr Thr Gly Ala Thr Ala Gly Gly Gly Thr Gly Gly Ala Thr 2180 2185 2190Thr Thr Gly Gly Thr Thr Gly Cys Ala Gly Ala Gly Ala Ala Gly 2195 2200 2205Ala Gly Ala Ala Ala Gly Gly Ala Ala Gly Gly Thr Cys Ala Ala 2210 2215 2220Ala Gly Ala Gly Gly Gly Ala Ala Ala Ala Cys Thr Gly Gly Gly 2225 2230 2235Cys Gly Gly Ala Gly Gly Gly Ala Ala Gly Gly Ala Thr Thr Thr 2240 2245 2250Thr Gly Thr Ala Thr Cys Ala Gly Gly Cys Ala Gly Cys Ala Ala 2255 2260 2265Ala Cys Thr Gly Cys Cys Ala Cys Thr Gly Cys Ala Gly Thr Gly 2270 2275 2280Gly Cys Cys Cys Thr Gly Gly Cys Ala Gly Thr Gly Cys Cys Gly 2285 2290 2295Gly Gly Cys Gly Ala Gly Gly Cys Ala Cys Cys Cys Ala Cys Gly 2300 2305 2310Cys Ala Cys Gly Gly Cys Cys Gly Cys Gly Cys Ala Ala Cys Cys 2315 2320 2325Gly Gly Thr Thr Gly Gly Thr Cys Cys Thr Thr Gly Cys Cys Cys 2330 2335 2340Ala Cys Cys Ala Cys Gly Ala Ala Ala Cys Cys Cys Thr Thr Cys 2345 2350 2355Thr Gly Ala Ala Ala Gly Gly Thr Cys Ala Gly Ala Thr Gly Gly 2360 2365 2370Ala Ala Gly Thr Gly Thr Gly Cys Gly Ala Cys Ala Gly Thr Gly 2375 2380 2385Cys Gly Cys Gly Thr Cys Cys Cys Cys Ala Ala Gly Cys Cys Ala 2390 2395 2400Ala Thr Gly Cys Ala Gly Gly Cys Gly Cys Cys Ala Thr Gly Cys 2405 2410 2415Ala Cys Thr Cys Cys Cys Cys Ala Cys Cys Cys Gly Cys Ala Ala 2420 2425 2430Gly Ala Thr Thr Cys Ala Cys Thr Gly Thr Gly Cys Gly Thr Thr 2435 2440 2445Cys Thr Thr Ala Thr Thr Gly Gly Thr Thr Gly Cys Cys Gly Cys 2450 2455 2460Ala Ala Gly Gly Cys Cys Ala Gly Cys Cys Ala Ala Ala Gly Gly 2465 2470 2475Gly Gly Gly Ala Ala Gly Thr Ala Thr Gly Ala Gly Thr Cys Ala 2480 2485 2490Cys Ala Gly Cys Ala Cys Cys Gly Ala Thr Ala Cys Ala Ala Gly 2495 2500 2505Ala Ala Ala Ala Thr Thr Gly Cys Ala Gly Ala Ala Cys Thr Ala 2510 2515 2520Ala Cys Ala Thr Ala Thr Gly Gly Ala Thr Gly Cys Gly Cys Gly 2525 2530 2535Cys Gly Cys Thr Ala Thr Thr Cys Thr Gly Thr Ala Gly Ala Gly 2540 2545 2550Cys Thr Cys Thr Gly Gly Gly Cys Ala Ala Ala Gly Cys Ala Cys 2555 2560 2565Cys Ala Ala Thr Cys Cys Thr Gly Cys Gly Gly Gly Thr Cys Gly 2570 2575 2580Gly Thr Ala Cys Ala Cys Ala Cys Ala Cys Thr Ala Gly Cys Ala 2585 2590 2595Cys Thr Gly Cys Cys 260014440DNAArtificial Sequenceforward primer 144attgggtacc gggccccccc gacgcagaag aaggaaatcg 4014530DNAArtificial Sequencereverse primer 145cgagggccat tttgtatctg cgaattgagc 3014630DNAArtificial Sequenceforward primer 146cagatacaaa atggccctcg cagctcaaca 3014732DNAArtificial Sequencereverse primer 147aacacagcac tcaggatagg tggctcgcaa tg 3214830DNAArtificial Sequenceforward primer 148cctatcctga gtgctgtgtt cctcagaatg 3014930PRTArtificial Sequencereverse primer 149Gly Gly Thr Ala Cys Ala Cys Thr Thr Gly Thr Thr Ala Cys Gly Gly1 5 10 15Ala Thr Cys Thr Gly Ala Thr Cys Ala Cys Thr Cys Gly Gly 20 25 3015031DNAArtificial Sequenceforward primer 150agatccgtaa caagtgtacc tgtgcattct g 3115140DNAArtificial Sequencereverse primer 151tggatccccc gggctgcagg ggcagtgcta gtgtgtgtac 4015220DNAArtificial Sequenceforward primer 152gacgcagaag aaggaaatcg 2015321DNAArtificial Sequencereverse primer 153ggtacacaca ctagcactgc c 211546384DNAArtificial Sequencesequence of example 2 154gacgcagaag aaggaaatcg ccccgccggt tccgtaaaaa aaatatgagc gcagggacaa 60gcacagcctt ggccctgggc ctagccttgc gccttgtttg atgcaatcgg cgacatgtcg 120aatgctgtaa ttttttttgt ttaggttccc cttttccttt tgtgttaata ataattctcg 180aagggcgctg attttgaaat ttgtcggtga gagccaaacg gatatacagg cgcggctgat 240gaataatgat gaatcgagct gacttgatgc tgtatgtaca atattgactg cgaggaccat 300caggtgttgt atggatggaa tcattctgta accaccaagg tgcatgcatc ataaggtatt 360ctcctcagct caccaacaac gaacgatggc catgttagta aaggcaccgt gatggcaaga 420tagaaccact attgcatctg cgcttcccac gcacagtacg tcaatgtaac gtcaaagccg 480ccctcccgta acctcgcccg ttgttgctcc ccccgattgc ctcaatcaca tagtacctac 540ctatgcatta tggcgcctca acccaccccc ccagattgag agctacctta catcaatatg 600gccagcacct cttcggcgat acatactcgc caccccagcc ggggcgattg tgtgtactag 660gtaggctcgt actataccag caggagaggt gctgcttggc aatcgtgctc agctgttagg 720ttgtacttgt atggtacttg taaggtggtc atgcagttgc taaggtacct agggagggat 780tcaacgagcc ctgcttccaa tgtccatctg gataggatgg cggctggcgg ggccgaagct 840gggaactcgc caacagtcat atgtaatagc tcaagttgat gataccgttt tgccaggatt 900aggatgcgag aagcagcatg aatgtcgctc atccgatgcc gcatcaccgt tgtgtcagaa 960acgaccaagc taagcaacta aggtacctta ccgtccacta tctcaggtaa ccaggtacta 1020ccagctaccc tacctgccgt gcctacctgc tttagtatta atctttccac ctccctcctc 1080aatcttcttt tccctcctct cctctttttt ttttcttcct cctcttcttc tccataacca 1140ttcctaacaa catcgacatt ctctcctaat caccagcctc gcaaatcctc aggttagtat 1200tactactact acaatcatca ccacgatgct ccgcccgacg atgcggcttc tgttcgcctg 1260cccctcctct cactcgtgcc cttgacgagc taccccgcca gactctcctg cgtcaccaat 1320ttttttccct atttacccct cctccctctc tccctctcgt ttcttcctaa caaacaacca 1380ccaccaaaat ctctttggaa gctcacgact cacgcaagct caattcgcag atacaaaatg 1440gccctcgcag ctcaacagca tactcaggcc gattggggcc gctggtctca ccagattcca 1500cagagttttc ccatgatggg ctctccagga ttcatgtcat acgatcccag agctcaggac 1560ggcagtcaga tgcagcgtca ggtgtctgct cagtacctgg tgaactcgaa ctacaaccag 1620cccccgatgc ccactgcttc gtctccccag tatcaacacg cagggccatt ttcctatgtg 1680ccttaccaca gcccgccgcc gtccactcct cttggttccc cattcaagag cgaatttccc 1740gagcaccctc ttacgcgcat gacacactct acggtcgatc gacaccattc tcaggccatg 1800agggactacc aaccttattc tcctgtatcg aggaggggat cgatttcttc agtcgccacc 1860aagccctcag cagctcccgt cacaccaggt ccaactactc ctggctcttt cacttcaagt 1920tccgacgccc agagccccag cactccaaac ccccagactg cgtctcagcc tgtcagctcc 1980aagactctca cttacaatga gaccgttcat ccgggcgata ggatcagctt cagaaccgat 2040gttgatgaac tcatgaaggc catccagaag acacagacga ccgacgagtg tcagcaaaca 2100ctcacacctg cgcgaacacc aaagaactgt accacaagta ctcccgtact tcgtacacaa 2160agcgggaagc cgagaaaaca gtgggtttgc gatggcccca actgcggcaa ggcctttgtc 2220cagaagacgc atcgcgacat tcaccgacgc actcacaccg gccatcgacc atacgtacgc 2280gcccagctcc tcttcactgc aacgccggct aattaaatgt tgataggtct gcaccatgga 2340aaattgcggt cttacgttct cgcagcgagg aaacctcaag gtaagcttca gctgctaaga 2400atctcctttg agaatgcgta tactgaccag atggtgtgtg gacagactca catacgacgc 2460cacacaggtg aaaagccgtt ctcttgcgct gcttgtggca agtgcttcgc tcagcgtggg 2520aatcttcgat cccacgagga gacacacaaa ggcctgaagc ccttcgtctg ccggctcgat 2580gattgcaaca agtcgttttc tcagctgggc aatatgaagg tatgcaacat ctagcacatg 2640aaagcagtat gagaacgctc taacgctgag ggaactgcag actcatcaga acaactttca 2700caaagaaacg ctccagaaac tcacacacat gtttgtgcaa ttctcggaga acggcgaggt 2760gcccagagac tatcaggatc ttttcgaata cttccagaag cactacaaga atagcaacaa 2820gggagtcaag ggccgaggaa agactcgcgc tgtggcagct cgtgggcctc aagattccgc 2880gtttcggcag gctgcctccc cagtgcccgc gttactgaag acgccggcta cgactcattt 2940gccccagatg acaatgccag cccatgatcc ccatggcaga atctcaccat acgccatgac 3000ccagggagct gcgaacactc tgagcaatgt cctgcgcaac cccaacccct cttacggcct 3060ttatggaccc acgtttgccc cgggccctgt acgagatggc gtctttcaca tgggcattgc 3120gagccaccta tcctgatcta gaaagaagga ttacctctaa acaagtgtac ctgtgcattc 3180tgggtaaacg actcatagga gagttgtaaa aaagtttcgg ccggcgtatt gggtgttacg 3240gagcattcac taggcaacca tgcatcctta ctattgtata ccatcttagt aggaatgatt 3300tcgaggttta tacctacgat gaatgtgtgt cctgtaggct tgagagttca aggaagaaac 3360atgcaattat ctttgcgaac ccagggctgg tgacggaatt ttcatagtca agctatcaga 3420gtaaagaaga ggagcatgtc aaagtacaat tagagacaaa tatatagtcg cgtggagcca 3480agagcggatt cctcagtctc gtaggtctct tgacgaccgt tgatctgctt gatctcgtct 3540cccgaaaatg aaaatagctc tgctaagcta ttcttctctt cgccggagcc tgaaggcgtt 3600actaggttgc agtcaatgca ttaatgcatt gcagatgagc tgtatctgga agaggtaaac 3660ccgaaaacgc gttttattct tgttgacatg gagctattaa atcactagaa ggcactcttt 3720gctgcttgga caaatgaacg tatcttatcg agatcctgaa caccatttgt ctcaactccg 3780gcaagtgtac ctgtgcattc tgggtaaacg actcatagga gagttgtaaa aaagtttcgg 3840ccggcgtatt gggtgttacg gagcattcac taggcaacca tgcatcctta ctattgtata 3900ccatcttagt aggaatgatt tcgaggttta tacctacgat gaatgtgtgt cctgtaggct 3960tgagagttca aggaagaaac atgcaattat ctttgcgaac ccagggctgg tgacggaatt 4020ttcatagtca agctatcaga gtaaagaaga ggagcatgtc aaagtacaat tagagacaaa 4080tatatagtcg cgtggagcca agagcggatt cctcagtctc gtaggtctct tgacgaccgt 4140tgatctgctt gatctcgtct cccgaaaatg aaaatagctc tgctaagcta ttcttctctt 4200cgccggagcc tgaaggcgtt actaggttgc agtcaatgca ttaatgcatt gcagatgagc 4260tgtatctgga agaggtaaac ccgaaaacgc gttttattct tgttgacatg gagctattaa 4320atcactagaa ggcactcttt gctgcttgga caaatgaacg tatcttatcg agatcctgaa 4380caccatttgt ctcaactccg gctagcgaat tctcgactca ttcctttgcc ctcggacgag 4440tgctggggcg tcggtttcca ctatcggcga gtacttctac acagccatcg gtccagacgg 4500ccgcgcttct gcgggcgatt tgtgtacgcc cgacagtccc ggctccggat cggacgattg 4560cgtcgcatcg accctgcgcc caagctgcat catcgaaatt gccgtcaacc aagctctgat 4620agagttggtc aagaccaatg cggagcatat acgcccggag tcgtggcgat cctgcaagct 4680ccggatgcct ccgctcgaag tagcgcgtct gctgctccat acaagccaac cacggcctcc 4740agaagaagat gttggcgacc tcgtattggg aatccccgaa catcgcctcg ctccagtcaa 4800tgaccgctgt tatgcggcca ttgtccgtca ggacattgtt ggagccgaaa tccgcgtgca 4860cgaggtgccg gacttcgggg cagtcctcgg cccaaagcat cagctcatcg agagcctgcg 4920cgacggacgc actgacggtg tcgtccatca cagtttgcca gtgatacaca tggggatcag 4980caatcgcgca tatgaaatca cgccatgtag tgtattgacc gattccttgc ggtccgaatg 5040ggccgaaccc gctcgtctgg ctaagatcgg ccgcagcgat cgcatccata gcctccgcga 5100ccggttgtag aacagcgggc agttcggttt caggcaggtc ttgcaacgtg acaccctgtg 5160cacggcggga gatgcaatag gtcaggctct cgctaaactc cccaatgtca agcacttccg 5220gaatcgggag cgcggccgat gcaaagtgcc gataaacata acgatctttg tagaaaccat 5280cggcgcagct atttacccgc aggacatatc cacgccctcc tacatcgaag ctgaaagcac 5340gagattcttc gccctccgag agctgcatca ggtcggagac gctgtcgaac ttttcgatca 5400gaaacttctc gacagacgtc gcggtgagtt caggcttttt catgatggcc ctcctaccgg 5460tgatctcagc tgtaggaaag agaagaaggt tagtagtcga catggtggcc ctcctatagt 5520gagtcgtatt atactatgcc gatatactat gccgatgatt aattgtcaac actaggcgcc 5580ggtcacaact agtagatatc acttacgtgt tgagaggcgg catgcgataa gaggtgtaat 5640tacctgagaa catcttgttg ccctgctttc cgtgcgaaat actaccggta cttttgggaa 5700acaagggaac aggagggcgc tgctgtgcgc ggttctgagt gttcaggatt gaagctgaag 5760aaggtgctga ggaagcgtag aactgttgcg gacgcgagtt ctgagaagag ctgtaccgat 5820tggtgaaagc cgaagaagtg agttggtgcc ctgttgcctg gataatgttt gcaactcgct 5880ggttctgcag agacggagac aaatgctggc tacgatgttg ctgattcagg ttgatacctc 5940ggtcgagaca ctgttttggt ttgatagggt ggatttggtt gcagagaaga gaaaggaagg 6000tcaaagaggg aaaactgggc ggagggaagg attttgtatc aggcagcaaa ctgccactgc 6060agtggccctg gcagtgccgg gcgaggcacc cacgcacggc cgcgcaaccg gttggtcctt 6120gcccaccacg aaacccttct gaaaggtcag atggaagtgt gcgacagtgc gcgtccccaa 6180gccaatgcag gcgccatgca ctccccaccc gcaagattca ctgtgcgttc ttattggttg 6240ccgcaaggcc agccaaaggg ggaagtatga

gtcacagcac cgatacaaga aaattgcaga 6300actaacatat ggatgcgcgc gctattctgt agagctctgg gcaaagcacc aatcctgcgg 6360gtcggtacac acactagcac tgcc 638415521DNAArtificial Sequenceforward primer 155gtcagaaacg accaagctaa g 2115620DNAArtificial Sequencereverse primer 156gcctgagaat ggtgtcgatc 2015718DNAArtificial Sequenceforward primer 157tcgtgggcct caagattc 1815818DNAArtificial Sequencereverse primer 158gacgcctgag aggtccta 1815920DNAArtificial Sequenceforward primer 159ccttcttaga gagctctcgg 2016020DNAArtificial Sequencereverse primer 160cgggtttacc tcttccagat 20

Claims

1. A method for producing a protein in a filamentous fungus cell, comprising overexpressing the TrAZF1 gene or of a variant thereof, in said cell.

2. The method as claimed in claim 1, wherein overexpressing the TrAZF1 gene is carried out by introducing a cassette comprising said gene into the genome of the cell.

3. The method as claimed in claim 2, wherein the cassette comprises: (a) at least one constitutive promoter; (b) the gene of sequence SEQ ID NO:1 or SEQ ID NO:3, or a variant thereof; and (c) optionally, a terminator.

4. The method as claimed in claim 1, wherein the variant encodes a protein chosen from the sequences SEQ ID NO:6 to SEQ ID NO:140.

5. The method as claimed in claim 1, wherein the protein is chosen from the group consisting of cellulases and hemicellulases.

6. The method as claimed in claim 1, wherein the filamentous fungus is chosen from the group consisting of orbiliomycetes, pezizomycetes, dothideomycetes, eurotiomycetes, lecanoromycetes, leotiomycetes, sordariomycetes and saccharomycetes.

7. A cassette comprising: (a) at least one constitutive promoter; (b) the gene of sequence SEQ ID NO:1 or SEQ ID NO:3, or a variant thereof; and (c) optionally, a terminator.

8. A method of producing a protein comprising expressing the cassette as claimed in claim 7 in a filamentous fungus cell.

9. A filamentous fungus cell, comprising a nucleotide with the sequence of SEQ ID NO:1 or SEQ ID NO:3 or a variant thereof.

10. The filamentous fungus cell as claimed in claim 9, wherein it is a Trichoderma reesei cell comprising either at least two copies of the sequence SEQ ID NO:3 or at least one copy of the sequence SEQ ID NO:1.