METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL

Abstract

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 14/946,512, filed on Nov. 15, 2015, which is a continuation of U.S. patent application Ser. No. 13/327,611, filed on Dec. 15, 2011, which is a continuation of U.S. patent application Ser. No. 11/887,104, filed Sep. 25, 2007, which is a National Phase Application of PCT International Application PCT/US06/11319, filed Mar. 28, 2006, claiming priority to U.S. Provisional Patent Applications 60/665,857 and 60/683,293, filed 29 Mar., 2005, and 23 May, 2005, respectively. Additionally, this application relates to U.S. patent application Ser. Nos. 12/904,822 and 12/904,981, both filed on Oct. 14, 2010. All of the above-identified applications are incorporated by reference herein in their entirety.

FIELD OF INVENTION

[0002] The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

BACKGROUND OF THE INVENTION

[0003] Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.

SUMMARY OF THE INVENTION

[0004] The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

[0005] In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

[0006] In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

[0007] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.

[0008] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

[0009] In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

[0010] In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.

[0011] In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

[0012] In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

BRIEF DESCRIPTION OF THE FIGURES

[0013] FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.

[0014] FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.

[0015] FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.

[0016] FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.

[0017] FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.

[0018] FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.

[0019] FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.

[0020] FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.

[0021] FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.

[0022] FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.

[0023] FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.

[0024] FIG. 12. Schematic of whole-mount EDIHN assay.

[0025] FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50.times.. Right panel: higher magnification: 400.times..

[0026] FIGS. 14A-14B. FIG. 14A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as panel but viewed under white light; right panel: tissue sections. FIG. 14B. Neogenesis HF proceed to next hair cycle.

[0027] FIG. 15. Schematic of creation of new HF by EDIHN.

[0028] FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.

[0029] FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10.times. magnification. Inserts: 80.times. magnification.

[0030] FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10.times. magnification. Inserts: 80.times. magnification.

[0031] FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.

[0032] FIGS. 20A-20B. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. FIG. 20A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. FIG. 20B. Graphical representation of enhancement of EDIHN by depilation.

[0033] FIGS. 21A-21B. FIG. 21A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. FIG. 21B.

[0034] Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17 d post wounding was included as a control (top left panel).

[0035] FIGS. 22A-22C. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (FIG. 22A). Mean values and standard errors of the up-regulated transcripts in non-activated ("bs-line") and activated ("expt") samples and fold-changes and differences between non-activated and activated values are depicted. (FIG. 22B). Raw data for up-regulated transcripts in non-activated and activated cells. "Ctrl" denotes non-activated and "High-dep" denotes activated cells. (FIG. 22C). Additional information about up-regulated transcripts.

[0036] FIGS. 23A-23B. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN FIG. 23A. 3.2.times. magnification. FIG. 23B. 8.times. magnification.

[0037] FIG. 24. Control mice lacked pigmented HF.

[0038] FIGS. 25A-25D. EGF inhibits HF formation by EDIHN. FIG. 25A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4.times.. FIG. 25B. High magnification view (10.times.) of skin depicted in (FIG. 25A). FIG. 25C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4.times.. FIG. 25D. Higher magnification view (10.times.) of skin depicted in (FIG. 25D).

[0039] FIGS. 26A-26B. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. FIG. 26A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. FIG. 26B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 .mu.m.

[0040] FIGS. 27A-27C. FIG. 27A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. FIG. 27B. Quantiation of experiment with 4 week old mice. FIG. 27C. Quantiation of experiment with 3 week old mice.

DETAILED DESCRIPTION OF THE INVENTION

[0041] The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

[0042] In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

[0043] In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

[0044] In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.

[0045] In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.

[0046] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

[0047] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

[0048] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.

[0049] In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.

[0050] In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

[0051] The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.

[0052] In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

[0053] In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

[0054] In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.

[0055] In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.

[0056] "Contacting" as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.

[0057] "Promotes a differentiation" refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.

[0058] "Uncommitted epidermal cell" refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.

[0059] The "HF cell" that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.

[0060] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

[0061] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

[0062] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administered in a solution. In another embodiment, the compound or factor is administered in a cream. In another embodiment, the compound or factor is administered in an ointment. In another embodiment, the compound or factor is administered in a slow release formulation. In another embodiment, the compound or factor is administered in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administered by any other method known in the art. Each possibility represents a separate embodiment of the present invention.

[0063] The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.

[0064] As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.

[0065] In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR.RTM. (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

[0066] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

[0067] In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.

[0068] In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

[0069] In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

[0070] In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.

[0071] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a .beta.-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a .beta.-catenin protein. In another embodiment, the compound or factor is an activator of a .beta.-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the .beta.-catenin protein. Each possibility represents a separate embodiment of the present invention.

[0072] In another embodiment, the present invention provides a use of (a) a .beta.-catenin protein; (b) a nucleotide encoding a .beta.-catenin protein; or (c) a compound or factor that activates a .beta.-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the .beta.-catenin protein, nucleotide, compound or factor.

[0073] In another embodiment, the present invention provides a use of (a) a .beta.-catenin protein; (b) a nucleotide encoding a .beta.-catenin protein; or (c) a compound or factor that activates a .beta.-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the .beta.-catenin protein, nucleotide, compound or factor.

[0074] In another embodiment, the present invention provides a use of (a) a .beta.-catenin protein; (b) a nucleotide encoding a .beta.-catenin protein; or (c) a compound or factor that activates a .beta.-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the .beta.-catenin protein, nucleotide, compound or factor.

[0075] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.

[0076] Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.

[0077] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as "eda"; in another embodiment, as "ectodermodysplasin protein.") In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as "edar"). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.

[0078] In another embodiment, the eda protein of methods and compositions of the present invention has the sequence:

MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAA LHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGP PGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGT RENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFI YSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVK MVHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0079] In another embodiment, the edar protein of methods and compositions of the present invention has the sequence:

TABLE-US-00001 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPC GPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRAT VLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAI AIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFS EKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPEL CLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPF DCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDR ISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275).

In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0080] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.

[0081] In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence:

MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLN ETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGL EFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0082] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

[0083] In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.

[0084] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.

[0085] In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

[0086] In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

[0087] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.

[0088] In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.

[0089] The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence:

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCE VVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAG CTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRN YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKH FKNCTSIS GDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTS GQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEG EPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNT LVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIG LFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLI TQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWE LMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFS K MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYIN QSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSP AHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0090] The EGF of methods and compositions of the present invention has, in another embodiment, the sequence:

MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGT NYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAIN WINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD LDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHN LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDD TWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCT LGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVL ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANS QDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERL IEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKR LFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVV VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGG EVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA TCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDID ECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSE CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKV IVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSC PQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSS DKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0091] The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQL S KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPA LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD CLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAG GMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLV RAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQL LYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMS EDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGY GQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0092] The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIG EGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC TQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNL HNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVR ASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASG CDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0093] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.

[0094] As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

[0095] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.

[0096] As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

[0097] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.

[0098] As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.

[0099] In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.

[0100] In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.

[0101] In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.

[0102] In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.

[0103] In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.

[0104] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.

[0105] In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.

[0106] In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.

[0107] In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

[0108] In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.

[0109] In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

[0110] In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

[0111] In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

[0112] In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.

[0113] In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.

[0114] In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.

[0115] An "inhibitor" utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.

[0116] The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term "abrading" refers to an act of creating an abrasion. In another embodiment, "abrading" refers to rubbing. In another embodiment, "abrading" refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.

[0117] In one embodiment, "abrasion" has the same meaning as "abrading." In another embodiment, "abrasion" refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, "abrasion" refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of "abrading" and "abrasion" represents a separate embodiment of the present invention.

[0118] As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.

[0119] In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.

[0120] "EDIHN," in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.

[0121] In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).

[0122] In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.

[0123] In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.

[0124] In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.

[0125] In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a "chamber" to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.

[0126] In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.

[0127] The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.

[0128] In another embodiment, the subject is an adult. In one embodiment, "adult" refers to an age greater than about 18 years. In another embodiment, "adult" refers to an age greater than about 20 years. In another embodiment, "adult" refers to an age greater than about 25 years. In another embodiment, "adult" refers to an age greater than about 30 years. In another embodiment, "adult" refers to an age greater than about 35 years. In another embodiment, "adult" refers to an age greater than about 40 years. In another embodiment, "adult" refers to an age greater than about 45 years.

[0129] In another embodiment, the subject is elderly. In one embodiment, "elderly" refers to an age greater than about 45 years. In another embodiment, "elderly" refers to an age greater than about 50 years. In another embodiment, "elderly" refers to an age greater than about 55 years. In another embodiment, "elderly" refers to an age greater than about 60 years. In another embodiment, "elderly" refers to an age greater than about 65 years. In another embodiment, "elderly" refers to an age greater than about 70 years.

[0130] In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.

[0131] In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.

[0132] In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.

[0133] In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.

[0134] In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.

[0135] In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.

[0136] In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.

[0137] In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.

[0138] In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.

[0139] In another embodiment, "several" refers to about 1 day. In another embodiment, "several" refers to about 2 days. In another embodiment, "several" refers to about 3 days. In another embodiment, "several" refers to about 5 days. In another embodiment, "several" refers to about 7 days. In another embodiment, "several" refers to about 10 days. In another embodiment, "several" refers to about 12 days. Each possibility represents a separate embodiment of the present invention.

[0140] In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.

[0141] In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.

[0142] "Disrupting" an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.

[0143] In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO.sub.2 laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.

[0144] In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.

[0145] In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.

[0146] In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, "mechanical means" refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to an electrical process or the use of an electrical current. In another embodiment, the term refers to electoporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.

[0147] In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.

[0148] Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.

[0149] In another embodiment, epidermal trauma is utilized in a method of the present invention.

[0150] Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.

[0151] In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.

[0152] In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.

[0153] In one embodiment, "following" refers to a period of time of about 2 days. In another embodiment, "following" refers to a period of time of about 3 days. In another embodiment, "following" refers to a period of time of about 4 days. In another embodiment, "following" refers to a period of time of about 5 days. In another embodiment, "following" refers to a period of time of about 7 days. In another embodiment, "following" refers to a period of time of about 10 days. In another embodiment, "following" refers to a period of time of about 2 weeks. In another embodiment, "following" refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.

[0154] In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.

[0155] In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.

[0156] In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.

[0157] In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.

[0158] In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.

[0159] In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.

[0160] In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.

[0161] In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.

[0162] In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.

[0163] In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.

[0164] In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.

[0165] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil.RTM.. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.

[0166] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.

[0167] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.

[0168] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

[0169] In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.

[0170] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.

[0171] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2'Z,3'E)-6-bromoindirubin-3'-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.

[0172] In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.

[0173] In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.

[0174] In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.

[0175] The terms "homology," "homologous," etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.

[0176] In another embodiment, the term "homology," when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.

[0177] In another embodiment, "homology" refers to identity of greater than 70%. In another embodiment, "homology" refers to identity of greater than 75%. In another embodiment, "homology" refers to identity of greater than 80%. In another embodiment, "homology" refers to identity of greater than 82%. In another embodiment, "homology" refers to identity of greater than 85%. In another embodiment, "homology" refers to identity of greater than 87%. In another embodiment, "homology" refers to identity of greater than 90%. In another embodiment, "homology" refers to identity of greater than 92%. In another embodiment, "homology" refers to identity of greater than 95%. In another embodiment, "homology" refers to identity of greater than 97%. In another embodiment, "homology" refers to identity of greater than 98%. In another embodiment, "homology" refers to identity of greater than 99%. In another embodiment, "homology" refers to identity of 100%.

[0178] Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.

[0179] In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.

[0180] In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

[0181] In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.

Pharmaceutical Compositions

[0182] In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.

[0183] The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.

[0184] In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.

[0185] In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.

[0186] In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.

[0187] For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.

[0188] In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.

EXPERIMENTAL DETAILS SECTION

Example 1

Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation

Materials and Experimental Methods

Depilation and Epidermal Abrasion

[0189] Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm).sup.2 cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.

Immunohistochemistry

[0190] Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.

BrdU Labeling

[0191] The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2'-deoxyuridine (BrdU) every 12 hours for a total of four injections.

Results

[0192] An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.

[0193] These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).

Example 2

Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation

Materials and Experimental Methods

Punch Wound and Excisional Wound Induction

[0194] The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.

Results

[0195] To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).

[0196] The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.

[0197] These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).

Example 3

EDIHN-Induced Hair Follicles Generate Hairs

[0198] At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).

[0199] These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.

Example 4

EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth

Materials and Experimental Methods

BrdU Labeling

[0200] 50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).

Whole Mounting and Immunofluorescence

[0201] HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37.degree. C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.

Results

[0202] To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. (panel is same as panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.

[0203] To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.

[0204] In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.

Example 5

EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle

[0205] To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.

TABLE-US-00002 TABLE 1 Results of three separate experiments performed on 21-day-old mice. Sample Expt 1 Expt 2 Expt 3 Avg of expts Std dev of expts 1 24 70 55 2 29 52 25 3 27 85 53 4 102 25 80 5 53 27 23 Average 47 51.8 47.2 48.67 2.71 Std dev 32.8 26.3 23.7

[0206] The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.

Example 6

In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN

[0207] The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.

TABLE-US-00003 TABLE 2 Efficiency of HF formation by EDIHN in adult mice at various stages of the hair cycle. Wound Days after Mice exhibiting Age size wound EDIHN Hair cycle 3 wk 1 cm 20 25/25 (100%) Telogen 4 wk 1 cm 20 5/5 (100%) Early anagen 5 wk 1 cm 20 1/2 (50%) Anagen 8 wk 1.5 cm 30 16/35 (46%) Telogen 14 wk 1.5 cm 30 1/2 (50%) N/A* 20 wk 1.5 cm 30 2/2 (100%) N/A* *The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF.

[0208] To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.

[0209] The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.

Example 7

EDIHN-Induces New Hair Follicles in Human Skin

Materials and Experimental Methods

Grafting

[0210] Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.

Results

[0211] To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.

[0212] In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).

[0213] The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.

Example 8

Molecular Pathways Activated During HF Stem Cell Activation

Materials and Experimental Methods

Isolation and Activation of HF Stem Cells

[0214] K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 .mu.g (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated "bs-line" and activated ("expt") samples.

Results

[0215] To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.

TABLE-US-00004 TABLE 3 RNA transcripts up-regulated during HF stem cell activation. SEQ ID No: Access. # Sequence 1 AW047343 uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucg ggcaccuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugag caaggaacaggacucugcccuggcaggguggagguggccucacagugucccaugcugggcc ugguagcgugaaagcacagcacgguagugggacagcuccugccgcacagccaccaccuccu gccgcaacagggcguuuuccuucuccaggaaggcagcccgcacagauauccgguucuccuu gagucuucuugcaucuc 2 AF053235 Sequence below. caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucgg- ugguggc ucuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuac- cuccucu cgcuucuccucugggggagucugugggauuggagguggcuauggugggagcuucagcagcagcaguuuuggugg- aggac uugguaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggc- ggu gguauuggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccua- ccuggac aaggugcgugcccuggaagaggccaacagagaccuggaggugaagauccgggacugguaccagaggcagcggcc- cacugag aucaaagacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaa- ugcacagu ucacuuugcagauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuug- cggcagu ccguggagggugacaucaauggccugcgcaaggugcuagaugagcugacccuguccagagcugaccuggaaaug- cagauug aaaaccucagagaagagcuggccuuccugaagaagaaccaugaggaggagaugcuugccuugaggggucagacu- ggugggg acgucaauguggagauggacgcagcccccgguguggaccucagccgcauucugaaugagaugagggaccaguau- gagcaga uggcagagaagaaccgcagagauguggaggccugguuccugagaaagacugaggagcugaacaaagagguggcc- ucuaaca gugaucuaauccagagcaaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacug- caguccc agcucagcaugaaagcauccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccag- auccaggg uuugaucagcaguguggaggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaaca- ucuugu uggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacucc- uccucac agcacuccucuggacaguccuauucuucucgagaagucuucuccucauccucccgccagccccgguccauccuc- aaggagca agguucaaccagcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucaccc- acaacugc 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aaguauuaucucucagguuaagucuagaguguuuuguccugguccccacggacacccggau caggucccauauaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaacc guuugugucuccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucug cgcaaccuccgucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuc cuaagccccagguucucccugauagcggcggaccccucauugaccuucucacagaggaccuc ccgccguacggagcacaaccuuccuccucugccagagagaacgauaaagaagaggcggccac caccuccgagguuucccccccuucucccauggugucucgacugcggggaaggagagacccuc ccgcagcggacuccaucaucucccaggcauucccacuccgcauggggggagauggccagcuu caguacuggccguuuuccuccucugauuuaacccuuccuuuucugaagauccagguaaauu gacggccuuga 4 AA681998 gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcagga uggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcau gucauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagagga guggaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagcca gaaccgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagc ugggaucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucaguga 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gcuuuuuaagacguauuauuaauauuuuggcuagcauaugguuuagugugagaguuuuau augcauaugucauuauacuuugcucauuuaugucuuggaacuucuucaacuagguagaaaa caugaccagggagaaugagaguaaggaaagaacccacugagacagacaagagcaaaccauac uucugcuaaucauguuuaaaaguccagaaaugaucauaccauauuuuauuuucaagugugg aagucagcauggagaggggcucuuuuucucuaaaggggccugaaauuaaauugacuugaug uugagguuaccuucucuuucaaugaaucacuaaauugucuuuucuguuucccaggacccaa gugcuaucuaaccaugaguucccaccagcagaagcagcccugcacuguaccuccucagcugc accagcagcaggugaagcagccuugccagccaccaccccaggaaccuugugcccccaaaacca aggaucccugccacccuguuccugagcccugcaaccccaaggggccagagcccugccacccc aaggcacccgagcccugccaccccaaggcaccugagcccugcaaccccaaggugccagagccc ugccagccuaaggugccagagcccugccagccuaaggugccagagcccugcaaccccaaggu gccagagcccugccaaccuaaggcaccagagccuugccaccccaaggcgccugagcccugcca cccuguuguucccgagcccugccccucaacugucacuccaucaccauaccagcagaagacaaa gcagaaguaauauuguccagagccaugccugaagaccugaucaccagaugcugaggcugcu gucuauccugcuuaugagucccauugccuugugcuaccaaugcugugaccuucagucuuaa ucccucucuccuugcaccaccuaaaaaguugacucucauccucaucuucaagggcuccugag ccucuuaacauugcccaaagucauauugaauggcuacacuuuucauggcucaggauucauc ugaagggggugaggagugagacaaguguauggucaauauuuuccccccauuaaaugccauu uaacucc 6 AI845584 uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucu uauaauaaauuccagcucaaaacuuuacaccacgaacaucauggagcaaguuaauucucccu uccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuucca guuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugacac ucccugaa 7 AA614971 aagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggauga aagcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaa auucaugcauaguuu 8 AV374591 aaccaaaugggaaugggguccccaacnuuncugugguaccagccggguuucucuugcauug gaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccuc uuagauuuaunuaauuaaccuaaguuguugaaguuucuguuucuccuuaagagaaauuaca aaaauucaacauugaagcauaguuucuuguuuucuguugucaaauaguaauaaugugcugu gauguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaa cauuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacac ugauucuuugugacaaauaugacccauuaaaaaugccuuuuaauagacuaacuuaccuuuu guagcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugauca uguuuaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaaggu ggaaugagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaa cucauguugucuu 9 U04443 gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcc aguguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaaggu ucuaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccug cccaugcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaagg ccuucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguc cuagucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaug aggacagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacg ggcccgauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccga gucuguucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccu ugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugc cc 10 Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg 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ggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacuccc uugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccu ugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggag ggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccuga gugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugagagu gagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuc cuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacug uagcacaucucugggcguuucccuacccagagaagagcc 11 M21285 Sequence below. uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcac- aucaacuu caccacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacug- ucuuagc caggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuucaaacg- uuuucu ggcagagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaacc- uauucc gguacaguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaaauauuuuauuuagcuaggauu- aaccau gccacaagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaaauaau- aacaauaa auuugaacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcuc- agucccu guuuguuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacu- ggccug ugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucc- cuccuug uuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggaugg- agaaauu aucuucauuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaa- gaugga agagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuacca- aagacccc aggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauua- aaucauu uucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuuc- augga aaaagucuucguguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugug- aaacuau gaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgaggugu- ugccugg guugccaguuucuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagag- gugca 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caaacac ucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguug- aaguag aaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacu- uuucuag

gucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccag- aucugau ucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucu- caaagaa ggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccu- gugagc ucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaauagucaagaggcuggcuggagagu- caucagu acauugguuugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggu- gggaa guaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcac- uggggc ugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccauc- ugcugg ugcuccagccaaggugccucuuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagag- auaaagcc uuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaagugucca- uagcauca gcucaggaggacacucugggagagugcugacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguu- cugaggu gauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacu- auauaug uuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacu- accuaccc acugccaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuauguggggu- aauuau uugugacccaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauug- uauuug uuccuaauaaaaguggaucugguuguacuguc 12 V00756 accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcu ugaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucu gcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguugg agaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuau uuuugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaa uaauuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaug aguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggu cgu 13 Y14296 auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaacc gcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcg cgaggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcugguc acuaucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugug cagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaau cugggucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagccca cucucccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaa gugccccuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuaca gagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucuc gcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcc cacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacacc guguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggug cuccccauggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacu gacacauggaaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuugg ccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaag ucaacauuugguccccuugcagaggcaacucugaaccgucucugacugaagauucagacug gugguguacauacgucunacugggugaguugaccccuggccucccacagugcagaaccacu cucuugaaucacauuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacncca ganacaccgaaacucuggauccucgaugcuugcugacucucagaauugnuunuucuucuca nuuaugcaagcnagagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaa acaacaacaacanaaaguuacuuauagucaauggauaagcagaguccgaauuuacacuaauc aagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaau uguacuaucugaacauaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaau acaugcuuugaggguagaanccgacggucuguuuggcaccacguuauaaucugcunnuuuu aacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuu ugacaaaugcugcggaugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaa augagguaaauaauuuuaacuuaugaauuuguuugaauuc 14 X16490 gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuu aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacagg cacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagau ucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaa ccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggug cuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaug ggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccucca ugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcaua cuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuu ggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacac uggaugaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacu caaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucu caggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcgugga ugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacu ggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaa uuacccacacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuc cacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaagu uuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaau uguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaaguca gaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuaca guguuauuuauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaa cuguaacacuacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaa uuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaa uguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaac ucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguug uauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccuga gauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa 15 AW120868 uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaa auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuaua acugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggau caacuagggcaaaauaaauaauuguguggaagcccuga 16 C78850 aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaa uggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuuc uggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuuga guuggugauacuguugggucanaaccagggccuguu 17 D67076 Sequence below. gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagauc- gagucaa aucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucua- gguccu gcagcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuu- ucuaagu gacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagc- aggccag cgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagcca- aaagucc cuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcuc- ucugucc gcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccac- ggaggaa gaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucugga- cgccuuu ggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggg- gcgcag ucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacg- gugaucc cggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuuca- uucagcc agcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguucc- acauccu gaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacu- cgcgacc cgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggac- caggaagc auaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccga- cuuccac ggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuag- gaauuca auuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagc- ucucacc cuucggaauuucugcagcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugc- aauucugu ucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugac- cccagca ggagcugcucagucauagaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuu- aacaugc cgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcuc- uccagc uuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccuagauaauggacacgggga- auguuug auggacaagccccagaauccaaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagug- ucaguuua cauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccucc- gguggcu uacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucagu- ggcaag ugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccgugggg- agacug cucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggaggga- aguacug ugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagag- aggagcag ugcgaggcgcacaaugaguuuuccaaagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgc- cggcguc ucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaaggu- uguagau ggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcau- cauaga cuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauag- ucacuag uacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaauc- aaagggg guccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacuc- uguccac acuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaaucc- gcagcuu uaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauuca- ccuacuuu augaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagug- cuccaag acaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugc- aaaggaa gugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccaug- uuccaaa acuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagag- cuguga uccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguuagaggaca- agguagc guggggaggggcugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugaggu- guggca aggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaag- guaguu aaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuuc- uuauaucu aucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaaag- auuggga aaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggagg- ggacaaa caagaucauuauucgaagucgcugguugcugugguuuuacggaagguugaugcaucauuccuaucaacagugaa- aaguuc agcuuguucaacgugacagaaaggcucaucuccgugaaagagcuccugauuucuucuuacaccaucucaguucu- uaacuau aguucauguugagguagaaacaauucaucuauuuauaaaauguacauuggaaaaaaaaagugaaguuuaugagg- uacacau aaaaacugaaggaaacaaugagcaacaugccuccugcuuugcuuccuccugagguaaaccugccuggggauuga- gguuguu uaagauuauccauggcucacaagaggcaguaaaauaauacauguugugccagaguuagaaugggguauagagau- caggguc ccaugagauggggaacauggugaucacucaucucacaugggaggcugcugcag 18 M61007 ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga cuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua cggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcggg cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc cugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuu uuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaaga gg cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa acuuuuuuggagaauguuuaaaagccaaaaaaaaaa 19 C85523 aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca ccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauag uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguuc ugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuauc aaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccggnucuuuu gagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunc cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc

uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg cuuuaacccnaucuuuaaaauggggg 20 AW122030 uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacuguc guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu uugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg 21 U57524 Sequence below. gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgc- auggcucac caccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugacca- uggaagu cauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuug- ccccgcg gugccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauaguca- cuuaguu cuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuag- ugagguc uuuaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgg- gaggugu cugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguag- acucca cuccacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcu- ccgagac uuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagac- cugcaca ccccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcaga- ggagggag agagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuu- ucuccuc gaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccuca- agacaau agacaugaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugca- ccuagcc ucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguac- aucucc cuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccuga- uugcuu uugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuu- cgcucuu guugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcc- caaguac ccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggaga- gcuauga cacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugc- uuugga ucagagggauuucaguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuu- guuuua agagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagc- acacguu caaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuc- cuacagc cuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucucc- ccuuauc ccaaugucuuggugaaguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugac- ugugug uuuggaggccagcgucugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaaua- gaguuu uauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccu- agacccaggc auuuuacuggggugauucggcuguugucuuugugaaauccgggg 22 U05809 cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg cuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcugg cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg agcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucua uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc uggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg agcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggaga ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu ggggagguaaauauauguuuug 23 AW212475 uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug cauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag cucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug 24 V00835 ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauaggg acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug caaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagc gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug gucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa agccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauu uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg cucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacu gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa auguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacu auuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug 25 AV374868 gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca cuauuuuuuaacg 26 M21285 See above (same Accession Number). 27 U74683 acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga ugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaaga aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg uuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccu gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa 28 X61800 gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac gagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagag cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcug ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc aaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucag cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc agcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa 29 U20735 Sequence below. uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgc- cgagaa agcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggcc- gcugccga ccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccg- cagcgagc ccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccu- uucuauc acgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccug- aaacccac cuuggcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggca- gugggg caggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgc- uugaucg uccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggc- agcggug gagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaaagcccuggacgaccug- cacaag augaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucua- ugcuggu ccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggac- cgccgugc ggacugggagcucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccg- gcacagcu ggguuugagucguggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgcca- cgccgcc ugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcgg- ccaccaa gugccggaagcggaagcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcgg- ggcuguc gagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcu- gccaguu gcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcu- gggcgcc ugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacugga- cuccggc ccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuu- uuucug caaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcg- gagcug gccgccgcuugguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauagua- cugugga gaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaau- cuauu uaagua 30 U19118 Sequence below

gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccgg- cagaguc cuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaa- gacugga gcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccuc- ucaccucc ugggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccaga- auaaaca ccucugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucacca- agucuga ggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaa- acaagaa aaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccaga- uugagga gcugaagaaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucaga- auggacg gacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagaggugg- cacggagg caauuggggaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugug- cacuucu agaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugccccc- gagugaa ccguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucag- augaccu agcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuuga- uaggugg ggugggaccacauccuccacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauuga- gguuguc caauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuuca- gagccu gguguugugcuauuuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauu- ucuga gagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcacca- ggggag ugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacug- cagagga agaacccugggcacagcagcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaagucca- acuuucaa aggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagacc- aggguug gaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagau- guggu ccagagcauuucagcugggagaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucug- uggaauc cucaguguuuaaucccacucaauaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccagua- uuccuag ccugucaacauaauaaauaucggaacaaaaccuggua 31 AW049031 uuuuuuuuuuuuuuuuugcugauaagaauucuuuuuauguuauucgaauaaaaaauaca uucauacagaaauauaacaaucucgcaaaaaacaauuucaaauaaaaucuuguaaaacaaa auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau aaagaaauuucacuaauagaaauuuuuuuuuuuaauuucaagcaaaaguuccugcuugau ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac acggacggcacccagccccagccaguccagcaacgucgcuguguuucauaagugagacgc gccagcacaaguuuccucucucuucuguuuaccuucuuacuuaauggaauugcuauggau aagcacacagcagggccaaaaaaggaguuuuccaaaauccagcaaaucaagug 32 M93275 uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucuc u uuucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug agaguggccaaccugcccuuggugagcucuaccuacgaccuuguguccuccgcuuauguc aguacaaaggaucaguacccguauuugagauccgugugugagauggccgagaagggcgug aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu guggucaauggcagcaucaauacaguuuuggggauggugcaguucaugaacaguggagu a gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu guccaccugauugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguuacca cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg cagcugcagaaaaugaaggaauccuuagaugaaguuauggauuacuuuguuaacaacacg ccucucaacuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuua g cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccug u guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug uggccuuuguauuguuauuggcuguaaacgucugucuggaccgaauaaagauucacgug a 33 AB000713 ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuu u gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucu a ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccug a guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaag u gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugc a guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu uuucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg uagcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaagg g caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacuc g gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggc u cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuuc c gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagaaggacccugg gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacag cuguaauuauuauuauuuucuacaauaaauggcaccugcauacag 34 U20735 See above (same Accession Number). 35 U83148 augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc ucaggugaagauuugcuccugaacgaagggagcauggggaaaaacaaauccucggcgugu cggagaaaacgggaauucauuccggacgagaagaaagacgccauguauugggagaaacgg cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu uuggagaacaagcugauugcccugggagaagaaaaugccacuuuaaaagcugagcugcuc ucccugaaauuaaaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauuc c accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu guagugggcaagucuucugauggggaagacgaacaacaggucccuaagggccccauccau ucuccaguggagcugcaacggguucacgccacgguggugaagguuccggaagugaacccu ucugccuuaccgcacaagcuucggauuaaagccaaggccaugcaggucaaaguggaggcu uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac uccagguaa 36 L10244 gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu ucuaccacugccugguugcagaagugccuaaagagcacuggaccccugaaggacauagca uuguuggguucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguau c uugaagacuucuucgugaugagugauuacagaggcuuugguauaggaucagaaauuuug a agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacuucuugguagcag aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug uaugugguuuggaggcagaauucuugaacaucuuuugaugaagaacaaggugguaugau cuuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaaugua ca cacugguacuuagaguuucuguuuugauucuuuuuuuuuaaauaaacucgcucuuugau uu 37 U88328 cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg accagcgccacuucuucacguugagcgucaagacccagucggggaccaagaaccuacgca uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga agacugucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac uuucccgcuggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccugggg g aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaaggg g ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuuguc u cuccuauguggggcuaggagacucgccuuaaaugcccucugucccagggauggggauug g cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu guguguugggguggcuuuuuucucucuguuuugaauaauguuuacaauuugccucaauc acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau auuuauacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaau gaaaaaaaaaaaaaaaaaaaaaaaaaa 38 X82786 Sequence below. aaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaa- gga gaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccac- aacc ggaagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaag- agc ccacagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaau- guu gaagagguuaagaagucuacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggag- gg uacccaaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugau- gaa ucagcaagugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaaag- cuc accaaggcgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguau- caa caucaaggcaaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccucc- aua aagcagacauuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguuc- aac ccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucagaucacucugagaaacuagcacaugaca- cca guauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugcagaagagugcugagg- gcc ucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuu- gcu

guccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagc- ag gaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagcc- ugu gaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaa- cag aagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaaugua- aaac agccaaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugcc- ucc caggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaag- aac augcuugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcug- cag aaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaa- ac uagagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaagg- agg augaagacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacua- ugu agcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccagugua- aa gaugaacuguaaauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucu- uc agacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcaga- aa uguggcccucuguccuauccaauaaagcucugaaauucgcugccaaaa 39 AW122523 uuuuuuuuuuuuuuuuuaaaucaaaaguuaugaugacuuuauuuuaaaucuuaauacac c aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaacacugcugu gauuucgcugugaggcuugauagugaauuuucccucugaauauggguuuagggccuagg a agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau gcuagugagucagguucuuucaaauguguccuaacuggguugcaaacauaguugcauccu uau 40 AI642048 gucuguaaaaaucuguuuaauaaauauacaucuuagaaguaccaaaauaauuaccaacaa aauacaacauauacaacauuuacaagaaggcgacacagaccuuaguugggggcgacuuuu aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu ggaaaaucaccucccccccccccaaaaaaaaucccacaaacaugaaccuuaagagacauu uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucau u uuuuuucuuuuucu 41 L07264 cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaacagacagacg aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc uuaguggaaccucgcuguccuccaccgccuggccccggugcaggcguccaguggccgccg cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagag u cuggagcggcuucggagaggucuggcggcagcaaccagcaacccugacccucccacugga uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcgugg cuagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacag ug guucguuacacguucuacauagaggagaaauauuucaccagcagccaugaaaacgucuuc auucauuuccaguugcuacccugacugggccuccuguaau 42 M15668 ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuuggacaagcugga cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca gauaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc ugacaaguacuccuuagagccaguugcugcugaacucaaaucucugcugggcaaggaugu ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc acuguccaaacuaggagaugucuaugucaaugaugcuuuugggacugcacaccgagccca uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagg a gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc ugagaaaaauggugugaagauuaccuugccuguugacuuugucacugcugacaaauuuga ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca gauuguuuggaaugguccuguugggguauuugaaugggaagccuuugccaggggaacca a gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggug g uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaug c ucucagcaauguuuaguauuuucuuuccugccuuugguuccugugcuccuaagcuaacc u gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugug g cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu cccagcuguaagucugcagaaauuuccgaauuc 43 AI047508 uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc aauaaaucauuuugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccau c aucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauau auugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagc cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug guuga 44 AJ001418 Sequence below. gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaa- cccuacgg auccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgc- ugagcag cgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugc- uggacuu ugguucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaaua- uccugaa ggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccaga- gccugau ggauuugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcugguca- aaguucg aaacagacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggacc- ccguuacc aaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagca- cauccuc auauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcagu- aguccaa gaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagu- caaugga aaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaa- gaaugcca ugagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaa- gaagacc uuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguac- uccacug cuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgu- cucuac gccaaguauuuucaaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaa- ggcuuua ucuucugagucuguagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagc- ugaugac ugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugac- auuuuac gggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaac- acaaaac caagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccggga- gaagucag ggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaau- acugaaa agaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggau- guuugg ugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuugg- cgccuu gggagaaauguguguaaauguacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaa- gcacuu uaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcucca- guaucau gcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaaua- ugcacu gaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacc- cauauga gagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguagugga- aauuuca aggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauuc- aaauuug ucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguaugga- aguaaa acguucucauaucaggaggaugucauuugugaagcauggggacaucaugaacuagugaugugcgugaggcuugg- gaggcu gaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaacgaggagcgagggaagcaauggag- agaggga agcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuc- cugggga gggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggug- aaauga uaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuu- gaaauu uguauuuaauuucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuu- cuuucu uucguucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuu- ccuuc cuuccuuccuuccuucuuccuuuccuuuucuuuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuu- uugca uuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugauca- cacaaaa cugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauuucagcucugaguu- ugugc acaugaauacuuacuuguguuuaccaaaggucuaaggcauuugguuacuuaacccaaauauccugaacugugcg- uaaagua auagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuau- gaaccca ugggagacuuuaaacucuuguagauagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacau- uuaugu uuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauaauagu 45 AI838080 uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuc c acagucaauacagaacuagccauuaucccagcacaccgauuugugc 46 AF072127 agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuug cagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagg gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccug g aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauu u caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu augaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcu gggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccgga aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag acuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauug aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga acagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug 47 X80417 Sequence below. cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagac- cc cgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguua- cca ugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaag- aa cggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgu- gu guggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcau- c aucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcu- gc agguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugu- gu gacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuuca- u gaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccg- ug guggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggc- cc augugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacauc-

ga ugucggcuuugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugagg- cc agcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcau- gg uagaggccacagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuu- gag ccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccauc- uac accccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugaga- acg agcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgag- ca ugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugc- cc uuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcag- gc cgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguug- g cgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugac- uu cuugggguaggguugcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggagg- a ggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaa- uc caaaaaaaaaaaaaaaaaaaaaaaaaaaa 48 AI847051 uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccag u ucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc 49 U09504 uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauucca c uauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaa c auccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcugu u cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag agcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga auuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaa g gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgauc u ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu cauccuuaa 50 U22033 auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccu g gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugac caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucu u cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu ccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaac uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga 51 AF033034 Sequence below. auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuag- augggag cagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacu- aguccag acucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauu- ggaccaa gagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagcc- ucucagc cccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucacc- ugugag ggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuu- ucgugac cacuauuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugug- ucugug uguguguguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagac- agccu ugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguaca- ccaaga caguuggccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucag- aaaugu gcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuuca- cccacug aaccaucucaccagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacg- ggucug gaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccag- gugcag caucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggc- ccagggac cuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauuca- cacgagg cccuucuccuccgaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuau- caggaa ggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaagg- aaagggg cguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggug- agggug gugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuu- auauggg ggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauauc- auaugg ugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaac- ggcuuc uugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugc- acaaag augcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacu- gcagcugg gguguaguguggcuguagaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaag- gaggaa uggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaa- gagagg gagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaaga- gagagg ugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagag- agaaaa gucaccaauuauuuuucuccccagucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaug- cacacaca cuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuu- acuucu aaauaaccaaucacacggaugccacaggguuccuuuagacuguccagggcuccggggcucuuagacuguuccca- auguggg ugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcaca- gaccuuu gcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauu- auuuuua guugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggca- ucgga uccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcg- ugguga gccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacag- ccacccca acuugccauccucauuuacuguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucuga- aagacuu uuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugc- caggcaa ccagcacguuugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuag- guugag agugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuacc- ggcaagg aaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuccug- gcagauu cugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggcc- uagccag cuaagucagaaaaggggacuuuccggugggaaugcauuuuccagucucuaggagaagucuuuauccaaauaaaa- uuagcau agugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccu- cugaugc aaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacu- caggcaa gacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugauc 52 AA960603 uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau cuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac aaggcauauucauguaccaccaacauuuc 53 U47737 Sequence below. ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagccc- gaccuc agguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgca- gcgugu aggaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcuc- uguucc uaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucac- uggguacc ccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcug- gggggug gggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugu- cuuauc caggauuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaa- ccuucc uccgcuggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucagg- ucccca gggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuu- ccuucgc uaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagaca- gcucag ggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaa- aacaaaacca gaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaug- ucagcaa gucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccuc- uaggagaa cuguaagccaccuuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaaga- ggccagug guauucaaaauaggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaa- gggcccag aaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguagu- ggagug gaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccu- ccagccc gugucucugccacaagagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgg- uucau gcaugcucauuuaucugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucu- ugguucc ccuuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuugga- gaaaga uuuguaggugccacgggagauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggcca- ggaauu cugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaagugggg- agaggc ucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauugu- ccgucu gauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccc- cagggca gcagggagucaauacugcucuccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauau- uggggag guguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcguagccugucu- uuuaac caacugccucucucacaguaggcuucuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagag- ucuuccu gccugugcuguuggcagcccuucugggcauggagcaagguauggagcucugagauaacccugcagccugguccu- ccuccu gaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuu- cccaccu ccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguug- acuuuag ccacuccaguaccaaagucugaagucaguugucauuggcuggcuuuuuucccugacccagggcugagcaugcug- uugcuu cuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauagg- caggugu caccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaa- acugccu guggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagc-

ugccug uuucccuagccagggccagggaccugcggggcuuuccccauuuccugcuacccugucugucuguccccucaucc- ucacuuu ccaugcagggaaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaauguca- aucucaau cucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacu- ucgugcc aguaucccacuacugggccuuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccaucccc- caugugu ucuccauauccccccagcucaggaaaagcccagcuccuuuuaggucccaggggacccuaggaaccuucagcucc- uccugggu gugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaa- gugguac uggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuugg- agucuca agaguaccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugu- gugcuca guguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcaga- aggccug ugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggag- gacugcc accccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuuc- cugcugcu auucuagugccucaaauaaaccguucacacccuu 54 L00039 cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug gacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccaggucc ucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga gcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcugg aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag cuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaauc g uuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaa acguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu 55 D21099 gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcug cgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugc aucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccugg agaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucu ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu gcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugag aacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauu gacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggc u cgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugag aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug gaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugag cagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaag aagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug aagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugc ggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaauggua gaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucga g agcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucu ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa cggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguu cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagug u ucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagc uccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccug u ggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagaua gugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaac ucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaau cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca aaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaa uguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaug guauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaag ucuuaaauguuucauguuuuug 56 AF026481 Sequence below. uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucac- ugugag uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccgguggua- gagagc uuucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugagg- acaaga cuaagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuu- cgucuaa acagcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggca- gcuagga gagagcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuu- agcaagc uccuuccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagc- aaaggaa cuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaa- ucgggug uucccggguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggcc- gcug aggauuaauaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaagg- cuuggg uggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugg- uaaggcg gcguaaggucacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaac- cgaggua cuauuuuguagcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugu- cccagu ugcuucugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucuc- agcugcu gucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggca- aaaacagg cgcagagguaaaaaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcuca- ggugau caaaaugcugggaaauggacgguuggaagcaaugugcuuugacggugugaggaggcugugccauauaagaggga- agcuga gaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugau- guaaucu uaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaa- acggacac auuugguccuggggaugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucu- agccug accuaagcaugcuaccuuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaagu- aaaacuu cauggcauguguaugacuuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaacc- aaagau guugaguuaucaucuuaagugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagug- agcacu guuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccaggu- ggccau cgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucg- agacuuc ucagcagaacuuauagauguguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagc- caugcca uuuuauacuuucacguuguauacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagu- gcaguu uuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaa- uccauua ucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauag- aaaauga aaaagagcagugagucuguucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacac- auaaaau auguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaa- uuacua uguguugauuaaaguuaguuacagaauuguacaagcuaaguuuuccuuaaacuaagcuuagguuaaagggagag- gagcca cagcucaaugaaaacacgguuccuguuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaa- aaaaaaaa aaaa 57 J04596 caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccg ccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggc ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac ccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagc ucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaa gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca auuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuu uuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucug cuuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauuggga gaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagag ag auagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcugu guuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguau ggucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccaua augggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagac guucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag 58 X81580 cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcc cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu ugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggug c uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggc aggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuauc ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg gaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagu g cuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca augaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga aguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagc ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau cccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuu ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc ccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguau ggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccug u gucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa 59 AI314958 gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau cauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcug agggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggu cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa cuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacu aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc ucgcacg 60 AF058798 gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagc uccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuugg a gacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucu gauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucau gaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccgu agccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucga gcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccggga gaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgca ccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaaggguga cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa ccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacag ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa ccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugaccc ccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccug gcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaac accuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauu uaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuu u gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc gaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugu gugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaa ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 61 AW046627 uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaug aucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacac cagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaac cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccag cgcagagugcucagggugacagggucuc 62 AI848050 uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccac ucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca acaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccu acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac uuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgagggg ucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaa acugcacuuuuauuuuc 63 AF065441 augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucuca gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag gguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucu cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugag gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu guuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaa cagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuug aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac

gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac aagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaau ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca uucuuccucaacauguuacaggcgacaucaugcuaa 64 AF022992 Sequence below cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggaugga- gggcgcu cgaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccuca- aaagcccc guugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccc- cuagaa ggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggcccc- gcagcac cggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaa- cggaccc gaguccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcugga- gaccacu gagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugc- gagcucag agcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaug- acugcacu ucgggagcucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcagu- acgcucu ggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugug- ccaugg acaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuuc- ucuguggc uguguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggaug- uguuuc ggggugcccgcuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucga- cugccca ccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaauc- agaggag guccugaccgggauccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucuca- gauggag ccccugcacagccgugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccu- gacaagag gaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguu- accuuccc caggaucuccugggggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaa- gaagaua cugcagcuggcaggccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccau- ggacacc agcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggc- accccu gaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucag- agcagauc caucgauugcugcugcagccugugcacagcuccagccccacggggcucuguggaguuggcccucugaugucccc- ugguccu cuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugac- uuuccag cagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagccccc- accccggc cccgccuccuugcuacagguacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggaggug- gccccagu uccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagc- agaucaac ugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuc- cuccucc uacacugccucuucagccucugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagaucc- gucguca gcaaugcugucuggggagggggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccu- ggccaau aaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaa- gcccccg gagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagccc- cacaguag ccccugacccaaccccagaugcuuaucgcccagugggucugaccaaggccgugcugucccugcacacacagaag- gaagagca agccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccc- cuggcug ccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccacc- accagaccc cccggcccgaaacucccugcuaugucucccauccuucaccugugcccucuucuggacccuggccacccccacca- gccacgac ccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuucccc- cugccccua caucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuaucua- uucccua ccccaccuaguuauccauauggggugucccaggccccuguugaggggccacccacgccugcuucccacucgccc- ucuccauc ccugcccccaccaccucucagccccccccaccgcccagacuccccacuguucaacucgagaugcagcuccccac- uccagcuca aucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugcuggg- ccccugc cucccagugaggagacugcugagccagaggccagauugguggagguuacugagucguccaaucaggaugcacuu- ucaggc uccagcgaccugcuggagcuacugcuccaagaagacucucgcucgggcacaggcuccgcagccucaggcucccu- gggcucu ggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagcaguca- gagcagc cauacaagcaaguacuuuggcagcaucgacucuuccgaggcugaagcuggggcugcucgggccaggacugagcc- uggggac caggucauuaagugugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcgugucaugaugac- auaccag gugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagcagcc- acgguuc ucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcccuuga- ugugau ggcguguguggacuguggcagcagcguucaagauccuggccacucugaugacccgcucuucucagaacuggaug- gauugg ggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcgguggugggggugaugguggu- gagg aggcccagacccaaauuggggcuaaggguucaagcucucaggacucugccauggaggaagaagagcaagguggg- ggcucau ccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcagucuaaug- agaggcu uccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugccccagcuuc- ucccaaca uagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaaguucuca- gccccau uuggaggauuguccacgcccgucccacugaggagacgggcgggucuucgguuaagguugcugacaagcugcuga- aguggu cuguccaaaucccagcugagccugagucccagucgcaggguuggggcugcacuuauuuauuugggagagacagc- ucacucu cccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaaccccuagcugc- uccaggg ugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguguucucagcucuaccc- ucuacc aaugacauuuguguuuuugauauugugucuguuauuuuuuuuuuaauacaaaaugacaaaaugaaaaaccaaaa- a 65 AF064088 Sequence below. gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagc- caggcag cucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaa- uggaacu aauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaag- cgcucau guccaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugaua- ccuccga ggaugacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagcc- ccucuga cuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaug- cugccaag ccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagc- caccagug ucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaac- uaucagga caauucuuuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucac- caaacaga uccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugcc- uuccuca gagacaguaauuuguaggucucagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuac- aguaucc acugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcac- aguuguc cccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugaggg- caccguc guguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacuguc- ucccauu gccccugcuccuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaaguca- caucugu agccacccaggguguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacagggga- aaaaccuu ucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacac- acaggug agaagaaguuugccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgc- caccuau cagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcu- uccgcaca gugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuuc- ugcaag gcuguggcccuccaaaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaaga- agugcuu cagccacaggcaggucacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucc- cuuauuu uagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuu- gccauu uauacuugagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacg- guacag aaauggagcuagaaaaugaguuuguguuacacagagaugucaucuucuccuagaguuaucuuguuucuuauucc- uagucu uuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguug- aacagc uguacauugcugugggggagccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauuc- uucuuu ggcauuuuguuuugaaaguuuaggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagau- uugaa aauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaa- auaugua uuauaaagaagagaugucaagaauuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacac- uuaacgu caagcauacacugugguuuuuuuguuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagau- ggacag ugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcu- ucuacc uugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuu- uaaagu gucaugaugugaucacaccugcaguuuggggcaucgaauccagggccuugcaugucuucuguaagagcucucau- cgcuga ccuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauaca- cuugguc gcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucuca- gagguuuc ugacaugcaaacuugaacccuugaaagaagaguuuucuuaaaaauuauaaaaaaucacgaguuacaauuugcac- aauauuu uuuguugaacuuuauaccuuguuuacaauaaagacuuuucuuug 66 AI787713 uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc aggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagg gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag uaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuc cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggagga g ccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucuca gaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauu guggccaagaagugucccagcugaggguucuccaucccaccaucuc 67 AI853531 uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu uaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggca gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca gaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcag ccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug ugcua 68 X14678 Sequence below. uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguua- uuucag caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccagggu- aaggaac ucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucau- cauguu cagucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucu- aagucaa ugccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagug- cuaucuc uguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuauc- uuuuga aaaugaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuu- agaccuu auuuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuuggucc- aauaaua caggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaug- aguuauc augagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccuc- uaaacu ucuguuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacuc- ccaccacc uccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugcca- guuugcu cacggccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccu- ccagggcc

gcugccccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccau- gugcugcg acaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuuc- ccugucc ucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugc- ugccccu gggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcac- caucuggg ggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagc- ggcagca gccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaagg- cgucucc ccaucuucaaucguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaag- agagggc agggacugcucauugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaag- augcaau aacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccua- ggguac cuaagauguuugagggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggag- cuuauu augguaccccaggcuggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguau- gcaccag ccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuu- uacuaga cccugaaguucaguguccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaa- uagccaa agccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagau- uuuauag uauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaug- cuauaa uauauuaauauauugcu 69 AI854358 cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg cagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucagu guacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucucc agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg gguc 70 X67668 ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucagu ucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucgugu c agaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucu uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaug aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu gaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucuga g cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu gguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaa gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau gugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca guaggaa 71 K02236 aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuu a aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug gauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaaga aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc gcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcu cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaa gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuug uacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc cguugacuugauu 72 X51829 Sequence below. gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuu- gcuacag ccugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccgga- cccacgau cgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccg- agcccaag accccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucaguc- gggccug gagccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaag- cugcggc ucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaac- agaguca agcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaug- aguacaa ugcaaagccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccg- cuggccug caaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacauc- acagcu ggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauag- cuccggg auacaaacccagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaa- acaaggcu gaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagca- ggagggag aagccaagguagaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccu- gagacaa cuuuugucuguacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagac- aacagcg auucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccugg- guguauc gcccaggagaggacacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugcc- acccccca uacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauu- cagcuga ggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggag- aggacaca gaggaagaaaacagcgauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucc- cuuccuga aggccuggguguaucgcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggcc- ccaggug acucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaag- ggacgugg ggaagagcccccucucuuccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccua- agcugcc ccuucgacugcagaggcggcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaag- cucggaag guacacuucgcugagaaagucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgagg- ucccugg gagcaguuugcacgagaucgaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccu- uaccccu gauuccagggccagagcaugggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucuga- ggccacuc ccuugacccaagaugugaccacacccucuccccuucccagugaaaccccuucgcccagccuguacuugggaggg- aggcggg gcuaagccugaguaguuuccuauuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguag- ugau 73 AW048937 uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgg gugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucuga guggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacag uccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagug cu uugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagc ucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa 74 AV139913 cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugau ggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaa uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuu uuuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguug aaagugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau 75 M32490 Sequence below. agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaagg- acacccgc cgccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucg- ccgcgcu cgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuc- cacuugac cagacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucg- gguuggu ccgggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcg- accacacc aagggguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcag- acccugu gaauauaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauuga- uggcgccg ugggcugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaa- gucagcg ggcagugcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccuc- ggacuc gaugccucggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcu- uccuguc uuuggcaccgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacguc- uuggucc cagugcuccaagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaa- agagaccc ggaucugugaagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagacc- aagaaauc cccagaaccagucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccu- gcguaga uggccggugcugcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuu- ccaagaa ugucaugaugauccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguaca- gccuauuc aaugacauccacaaguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaag- caucaug gagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugcca- aggggc ugauguggacggacagcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagc- cgcaguu ggagaagacuucgcuucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguuc- uguuuu cuguuuguaaauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauugua- auagag acaaaauaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucau- uccuucc cgagcggagggggacacucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagg- uguuuua agauugaauguuuuuuuauuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuug- uaaau gauuuuaauuuuauaucagugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa 76 AI121305 ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacuc ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu ucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccac caccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccugga ucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua 77 U35374 auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac acugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugc u cacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcaca gugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugau g augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacu c aaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccuggu uucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccu gccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaa augggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuu gagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugag c acagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacuc auuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguu cuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggag agcauuccacucccggaucguggcagcuga 78 X15643 Sequence below. uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaac- ucacauuu gucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaaugg- cuggcgc ucucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauugg- agaaucg agcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugug- cccuaaau gucagccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuau- caaaca uaauacaugugaaaucaaaccuugaaaauuaauuuuuuucccaacagucaagacauuugccagcugcagagauu- agcauuu caugaaucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucug- uaguuu uaaaaugaacuccacaaaacauguuuuuaauauagggaauuauaugaaauuguggggugggcagcgagguuaaa- ggcagaa auagcccaaugguggcacauucacugacacagccuaaaagauuagcaaauuacccagccaacacauacaauuaa- uacaauuaa uauuuuuauaguuaaaacagaguuacuaaagaaauuguuugaaaagaaaauuaugaagacuggaaagacggcuc- agugcuu aagagcuuuggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuauc- uguauau ucaguccuagggaaucugaugcuuuguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguaga-

gauaaga cucccaugcacagaacauaaauaacguaguuuaauuuuuuaaauuguaaaacugaaaaugguugcacuugcauu- uuuauuu ucagcacauccccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagaauuacaccuc- ccaacccua cccaaauguguauacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugcgguucucaaggaggg- aggaugc caaaaaaauauuuuuucacaaagugugcugagaaacucuguagcuguuggagucaucuccugugcucuugccaa- auaacug aaaggggauacacuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggaca- cggugu cugagugguccgcacuccaugucuccacaggagcgcuuauguguguuucuuuccuccugcuucuggguguuccu- ggguuu guuuacagccaccucucuguuggaccaggagacagcugucgucuccagaaugagcgggcacgggugugucucgg- uggcug uggcugugguucggcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccggg- ugagc uugcucuuucuguuccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagagguga- ccugaac ggacagguagcaccuccagacagcgccugguuggcggguugcacagcagccccagauuucucucucuggugccc- cagcuag gguagcuggaagggagcgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggcc- ggcuag gcugggaggguuagcccuuggugcccuacgccugcccgggccagucgcggccgccggccauuggcccaaagaau- uguugca cgucacuggcaauuccccuagaagucugugcacauaacgggcagggcgcacugcaaggcugcuucucccgcauu- uaggcug cggcugcaggcaccgcgagcccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacg- gccgcuga augaagcuuccaggaguccgcccccggccgucgccccgucggaggugcacccgcugagagcgccuggaccgaaa- ggccggu gcgcucaccugcuaaccugccagccauggggccacacgggaacgacagcgacuucuugcuggcacccaacggaa- gccgagcg ccacaccacgacgucacucaggaacgggacgaagcguggguugugggcauggccauccucaugucgguuaucgu- ccuggcc aucguguuuggcaacgugcuggucaucacagccauugccaaguucgagcgacuacaaaccgucaccaacuacuu- cauaauc uccuuggcgugugcugaucuagucaugggccuagcgguggugccguuuggggccagucacaccucuaugaaaau- guggaa uuuuggcaacuucuggugcgaguucuggacuuccauugauguguugugcgucacagccagcaucgagacccugu- gcguga uugcaguggaucgcuauguugcuaucacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccga- gugguca uccugaugguauggauuguaucuggccuuaccuccuuuuugccuauccagaugcacugguaccgugccacccac- aagaaag cuaucgauuguuacaccgaggagacuugcugugacuucuucacgaaccaggccuacgccaucgcguccucgauu- gugucuu ucuacgugccccugguggugauggucuuugucuauucccgggucuuccagguggccaaaaggcagcugcagaag- auagac aaaucugaaggaagauuccacgcccaaaaccucagccagguggagcaggaugggcggacgggccacggacuccg- aaggucc uccaaguucugcuugaaagagcacaaagcccucaagacuuuaggcaucaucaugggcacauucacccucugcug- gcugccc uucuucauugucaauaucgugcacguuaucagggacaaccucaucccuaaggaaguuuacauucuccuuaacug- guugggc uacgucaacucugccuucaauccucuuaucuacugucggaguccagauuucaggauugccuuucaagagcuucu- gugccuu cgcaggucuuccuucgaaaccuaugggaacggcuacucuagcaauagcaacggcagaacggacuacacagggga- gccaaaca cuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaac- ugucaa gguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacag- gcuuucu acucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacuuuagaauaaaau- uguauaga gauuugcagaagggggggcacauccuucucgccuuuuuuuaauuuuuauuuuauuuuuuagcugcaaacaagag- agagaa cuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaaga- guguu gguucugaggacugagucugucugucugucugucugucugucugucuggaugauguuuucauguaucuaccuca- cuggu caaguauuaagaaugauauauauugcugcuggaaauccauaucuaaaggagagaguuuucuuccuguacccuug- gacuuga aauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaaug- gauucga ggcagggauuugagggacaacacuaguuguuuuguuuuuguuuuuguuuuuuuguuuguuugguucguuuuugg- uuug uuguuguuuuuugggguuuguuuuuguuuuuguuuuuuuggguuuuuuuuuuuugcugagaaaagucuaaaguu- uaca guaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuuguc- ucuccca cuggaaaccacagguaaacuaugugucgugaccgaugaguggcuuaauguguaagaguaccagaauggcaugcu- ugcaugc accgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacucgug- ucccaaa gcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaacccu- gacucac ggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuugcuuaauaa- cugugua uauuuacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguguguucaggaugaggaag- auguuc uguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagagagag- caaagcu uuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuucug- uucccaa uucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggcacgu- cuguac caguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacauau- gcagacac u 79 AI849109 uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac cagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcu gagugaccccacca 80 U70132 agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaaga agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccgugugga ccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaa agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca agggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacg ucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca gggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuga cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguua a cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac uguauguuucuaacauauuauuauu 81 M13805 cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac cugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgc aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag gcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccug gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu gaaauaaaugaccauggugac 82 AV138783 ccccaggggugaaaugaggauucccccacccugcggaacagugaaauguguauaauuaag aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu uuuacuacagagacauuccaauaaauucguuaagcc 83 K02927 Sequence below. cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucu- agcggcg augcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacu- cuguuau ggacucaacauggacuuuguugauccugcucagaucaccaugaaaguaauccaaggccuauauaguggggucac- cacagug gaacuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagc- aaggauag ccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaau- ccgcacaa cggcagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucug- ccauuau cuaugaccgagauuucucuuauaacuacuuuggcuuuaagacacuggaacggucauauuuguugaagaucaaug- guaaag uggcugaaagaccacagcauauguugaugaggguuucuguggggauucacaaagaagauauugaugcugcaauu- gaaacc uacaaccuacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccaca- gcugucua gcuguuuccucuugaguaugaaagaugacagcauugaaggaauuuaugauacucugaagcagugugccuugauu- ucuaag uccgcugggggaauugguguugcugugaguuguauucgggccacugguagcuacaucgcugggacuaauggcaa- uucuaa uggccuugugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccag- gcgcguu ugcuauuuaccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacaggcaaggaag- aacagcg agcacgcgaucucuucuuugcacuuuggaucccagaucucuucaugaagcgaguggagacuaaccaggacuggu- cauugau gugucccaaugaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgaga- agcagg gucguguccgaaaaguuguaaaagcucagcagcuuugguaugccaucauugagucccagacggagaccgguacc- ccauaca ugcucuacaaagauuccuguaaccggaagagcaaccagcagaaccugggaaccaucaaaugcagcaaccugugu- acagaaau aguagaguacaccaguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacac- cggaaca uacguaugacuuugagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaa- acuacua cccuauuccagaggcacacuuaucaaacaaacgccaucggcccauuggaauugggguacaagguuuagcagaug- cuuucau ccugaugagauaccccuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuaug- gagcccu ggaagccagcugugaacuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaagggua- 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aaaccuaa gggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagagguggaa- gaggu ggauuuggaggaagaggccggggaggcuuuggagguaaggaagggaaaggaacuggaaacggauuccuaaaccu- gugucc uaaccaaccaccuuaaaugggaaggucaguccuaauuguaucacccuuugauguuuuuccuuccuauagguaga- ggaggcu uccgaggcggcagaggaggagggggagacuucaagccacaaggaaagaagacgaaguuugaauag 85 X57800 Sequence below. uuagacgguugcgcgcgcagaggguugguaguugucgcuguaggccuucgcugccgcuucugcaucgugaaucg- ggggac cuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggc- acgccug auccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucag- cucgggc ggcgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucga- cacauac cgcugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuu- cccgcuu ccgcucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuaug- gugucg ggggcagcccucaccaaagcgcgcgguuccgaaaagcccgcgcuggcaguggcgcccacucuguuuccgcgcca- aagccaca 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ugguug gggguguauguagcuuuauguguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucaca- aaaugu ggaaagaguuguauuaaaugcucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaa- cugaugu acucaaagcuacagcaggaagauucucagcuuaaagucaaccuggcagaaaaucuagcucaaaaagaaugagga- agaaauug ggaaggcaaaggaagauguucuccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaagu- aucccug aaucgaggcuuuuucucaggaauccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaguuuugcu- agcuag ccugagcaucagaauuacacacagaagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagag- ugcuucu gcaaguauuuaagguaaauauaagguguuacuuggccucugcaugaauuuaaaguaaaugaaaguguaagaauu- cgaacau agauaaacacacaacccaagaacuaguucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuuca- gcuccuca guucucaaauacugacauguaauucaucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaag- gaauuuu ucaguauccacauguucaaggauugggaauugaauaaaauugauaaucauacaaugaagacugguuuacugucc- cuuagcu ugcauucagcuguugguucuuguuuuuggaagugguuauguguuaucuuccucucuucaugcauucuuugcaag- agaag uauguacaaucugaauaggaacaacuuucuccuuuguuuugauugcuugggguguggcucuacaggaugggcaa- gcuaga cuuuuuucuucuuuagucaagguuuucaucaacccuuccaaaaugauaacuauuuguuuugcuuugugguauaa- uaccgu gaucuaauagugugaguuucugaugucuacagugagccuguuuucuccucuagguaaccauagagaugaaugag- ccuguu caccuaacguuugcucugagguaccugaacuuuuucacaaaagccacuccacugucuccuacaguaacacucag- uaugucu gcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugguu- uaauu uuuccugucuuucaguuguagaguauaaaauugcugacaugggacacuuaaaguauuauuuggcucccaagauu- gaagau gaggaagcaucuuaggcauugcuagaaauugagaaaacuaaaccuuugaagauugcuccugagaugccagcgug- uccugag gucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaaaauaaaauauguagauaucuucuguaaa- uaaccua cuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacaug- aauguuu cugcuuuacaaauacuggugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguucaau- uuaaaua aaguuaacaauuugaaaaguca 86 M35247 Sequence below. ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaa- acaga ugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucug- gug uuuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaa- agcu guccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggau- gcca gaccauccuggacucggaucccuuuggguauuucuacaccgcugugucccggccuggccuuggggagcccuggu- ucau aaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccu- ggcu ggagcaggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaagga- aucug augacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaaggcugcgaugu- ggagc cagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugaacgaaaac- ccaagu uccuguacagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugca- gaaau accuggaaaaagggaaggagaggcugcugcguucagacccuccaaaggcacaugugacccgucaccccagaccu- gaagg ugaugucacccugagguguugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaaugggg- agga gcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugg- uggu gccucuugggaaagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagau- ggga gccugcaugguaccaaaagccuuggauuuggauuguugccaugguuuucauuuuguucaucauuugucucugug- ugg uuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccc- caaga cucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuuguc- uag gccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugc- cccu uugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggc- ucaag gaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggac- acaaa gcucccuccucucacccacagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugg- gauca auggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu 87 AI553024 cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuaca uccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag uuaacuc 88 X16995 Sequence below. ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcggga- ccaggc ugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuuc- uguuuc uagggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgag- gagggg uguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagc- gggcg aagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccag- uguga ggcacucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguac- ucaga gcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucag- cccccuu ucccaguguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaac- cgugcu ggaagaccuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguuguc- agagu aucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcuca- cgauaga gucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuu- gaaucu guuagguagggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucc- cacuccc ucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucu- uguguug cugacuaucggccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacagg- auuuga auggagcuggaacaaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccag- gcuucuug caaacagaggcagaaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggc- aggcgg ggugggaacugguuggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccug- gcuag gcacccaggggugguguggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauag- ucuuuu ucuccaccccacccucugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagc- acccucugc cuccagccacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccuc- ugccucag uguuccugugugaccugucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaaggg- acacuag guccuggagccuccucugugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucau- ucaggu gcuucagguuugugaccuuugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagc- uugucu cugugcauccgcugguaggauccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuu- acaaaa ugacaagguuagggggcuggagagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaa- cuccug uuccaggggggaucugacacccucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaau- aaaugacc ggguuagcugagaaauuccuuuugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcuca- guuccu cgccucccuuccauauaugguauuuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuaua- ugugu cucugugugugcacaugagcauggguguccuacaaggcuagagacaucagauguccuggagcuagaguuacaga- ugguug ugagccaccugauguaguugcugggaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacuga- gcaacu ucuccacgcggcccccccccaguauacgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcug- gggaugg ugagguggccuaguuccccccaacuccuggaaacaugucagaaaguacagagugggugccugugggaucagcau- gcgggg gguggugguggugagguguggggcugcuuucucccgaggcuaccgugauagacaguuguaccuugcuggcagcc- ucuacc ccauuuccaggaugucagucucugcagacguaugggggacgguggggaagggguauacagagccaugggugugc- cuggga auguacucccaggaagugacugguugaaaagucagcagaucuccugggggauagaggggugggcugaagcucug- uggguu gccucucucagcccugaccugugaacagggaggcuggggguuggaggaacacagcuucccccuguuccuggggg- gacaug cuggacagccuuuccuagcucccccggcccacugggguguggcuggucgucggacugagcucuuuuggaccugg- ucucug ccugugagcuuugugacucguugagauagcauuugggcugagggauugggagucuucuguucuuugguccugac- acccg cuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuac- ugaccccu ccuccucccuccuuugugucuccucccucuccagagaugcccuguauucaagcucaauauggaacaccagcaac- gagcccag gaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccagcccc- gagacagc accugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuucc- ucuaccag cugccggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggc- caccucc cccgcuucggcguccuucaaguuugaggacuuccagguguacggcugcuacccgggcacccugagcggcccauu- agaugag acccuauccuccagcggcucugaguacuauggcagucccugcucagcccccucgccaucuacacccaacuucca- gccguccc agcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuaugaaggccucugggcauggaca- gagcagu ugccuaaggcuucuucagggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagcccc- agccuggc ccagaguucucugaaauuguucccaccaccagccacccaccagcuuggggagggggagagcuauuccaugccag- cagcuuu ccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaagu- cccggagc ggggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccg- caccug ugagggcugcaagggcuucuucaagguauuuuguugguucugggggacgaugauaucauguuggaggugggggu- ggagu gggucauccguugggaucuguagugaccucuccugagguuucuucccagcugguucuguccugcaggacgaggg- acaggu gugugccaucuuagaggcugggacuuuuuauucagcagggcacacaucucucuagggcugcagaaagcugggga- aggggg cagaagguguguguguguguggccugcaguggugcucagaaacagaaaaccuagugggcagccucugguucucc- acagaa cuuguguuucuggcacuggaugaaaggacacaggcagaggguuugguucuugcuggggguggacuugggaacag- gcugu guguuugucccagugcugggugccugcuuggcnnnncccaccuccanccccuuaguccucuccucugcgccagg- aaaagg gcagguggacacaugcagacaccuguuagaacaggugucuggacggccgugggaguuccuagacccuggucuug- gguucu gggaucuucccugugagguugaaaccuucuccaguaucucccagacuccucucugcgcucuggcccuccguuuc- ucccucc cccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugucugcgucggccacaggaucuggac- ggucccc uccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuccguguccccccuuccuccagcg- cacaguac agaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaagaggcggcggaaccgcugccag- uucugcc gcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagauggugcccucggcauaggcgac- cugaug gggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucuagauuccagccccuaaaugc- aggugua gcuuccaccugcuuucuggaaaggguggggugaggagggccuugugggguccccaucauggucugaguucucug- ucucu gacuucucagaagugggguguauagugugcccugaagacccuccuucuccaggucuccuuucucaauacugccc- gucucuc ugcaguuguacggacagacagccuaaaagggcggcggggccggcuaccuucaaaacccaagcagccuccagaug- ccuccccu accaaucuucucacuucccucauccgggcacacuuggacuccgggccuagcacugccaaauuggacuauuccaa- ggugagg ucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuaggaaaggcucucccucc- agggcaa caucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggauggguguggggucggggagc- caguua caaacagcugccguagcccuguuuuccugugggaauugacaagcacaugggcccagaauagggcucuuuugcac- gccugga ucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggacccaaugcaggacaca- gcugug ugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucauguggaacuuaccugc- guuccu uucaguuccaggaacuggugcugccccgcuucgggaaggaagaugccggugacgugcaacaauuuuaugacuug- cucucu gguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccaggagaccaaga- ccuguug cuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccauccuccuagccc-

uggcccca gcccugcggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaaacccgguga- ggggaag cucaucuucugcucaggccugguacuacaccagcugcagugugcccguggcuuuggugauuggauugacaacau- ccuggc cuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucugguccucauca- cuggug aguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuuggggacccc- uagagug ccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucagccuccg- aaugacc ccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggauucuguuuguuuaaaaaccuagcugu- caaccuc acaagacacaggaacgugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccaugguccagaaac- aggaccua cuucagcucuguugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggcauuccu- gucaug gauuuuacugugcguaucacaggguauggacucuaguguuaaauguagagguuucugggucccuucucguuccg- cuccca uuuccacuuaaauuucuuaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguagggag- ugauau cuacacccagcucaguccuuagucuguccugcgagacuccaggauuuuagaacaguguggagccuggaccucca- gaaaacc uggauuaggcuuuugccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcuccugug- ggacgu gcuagagggcuggggaagcuugucagggagaaggcgucaacugagcggggcugacucuaccuucccugcugcag- aucgac acgggcuccaggacccucgucggguggaagagcugcagaaucgcauugcuagcugucugaaggagcacauggcu- accgugg caggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcuucggacccugugcacu- caaggcc ugcagcgcaucuuuugccucaaguuggaggacuugguacccccuccaccuauuguggacaagaucuuuauggac- acauugu cuuucugaccccugcccugaacaugugugcgcacacgugcgugcucuucugucacccaugugccuuuaagccua- uagccca cggacccccagaccacccuacccccagccugguuuugagcuaagacugacguaccuccucacuccagaagaugg- acagagaa cucaagaccugggggaggguguguauucacgggggugaccccacuauuugucuuaucccuccagcucaguccug- gccuuc guguguuuuuguaagauaaaccauuuuuaacacauaccacucuguuguaaauaagcugacgcuacuguaaauac- agaaagg aagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgagaucuc- uuccgc ucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauuuauauuuguguauuuucc- uggauu uauaggaugugacuuuucugauuaauauauuuaauauauugaauaaaaaauagacauguaguugaaa 89 AF038562 ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg uccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguucc auguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccga ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg agcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgcca cagaggaaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggc ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga auaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuuga ucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 90 Y11666 gccacauuguugcaccaacuccagugcuggagucucaggacaccaca ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc ugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuua gugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagu gagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa acccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuug uguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucgg acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa aaccaagugcaga 91 U40930 Sequence below. cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcaagga- ggag g cgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggc- ccggg g cccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacua- ccgc g augaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugac- aucu uccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccga- aacau ggugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcc- caga cuacgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccu- uuggc caccucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcug- ggag augggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugaguc- agcuu cugcuccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccu- cuagg cauugagguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguucca- gcaca ggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcugggga- gggcc cugcucagucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggag- ucggg aaacugcucaggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacucc- agucu cuacagaugccagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagc- ugcccu auacccacaucucccaccagaggcugauccccggcugauugagucccucucccagaugcuguccauggguuucu- cggau gaaggcggcuggcucaccaggcuccuacagaccaagaauuacgacaucggggcugcucuggacacgauccagua- uucga agcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagc- agcag ggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucag- gcaa uaggaaagugcaugaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcug- agcu gagcuuccucugcuuccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuug- ccgcc agcauugcaccagcaguccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacug- cuagu uauuuucaacaaauaaagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccu- acag cuccuagggaauggagaauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggcc- acucu uuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaagu- aacc uguaauaaaaugccauaugcacuuuaacca 92 D26090 Sequence below. gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugaccc- aggu a cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagag- ggcc a ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgg- gcuuc a ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggac- cuggc c aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugc- caagg a gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagu- cagau g ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauu- ucagc c ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgc- caugcc caggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauc- cauac uucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcaguccc- ucaug gugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacaggguc- acca ucaugggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauc- cgga gcucguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagc- ccac aggaagaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuuccccc- uccau cuuugggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagaug- gacu cacucgccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuug- ugga gaagugcucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauac- ggga ccccucaucucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaug- aguu ugacaagaugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaag- cuggg aucacuaccaccuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagac- aaaag gggaggacaauauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcac- aauga ggagagggacaugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcugugg- aggg ugagaucgaccuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcag- aggca gcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcg- uucca gcauccccaucacugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcag- cccuu ugccacugaggcugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggca- aucu gucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgcc- guuu ugccauuggcucucaggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcua- uccga aaggugcugcagcucaugcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaa- gugag cccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuu- uugccc ugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucau- acug uguuugagugucugaggacucucugcucugggugucuauccccugucaugccuucucaacaagaugagucugga- gcag gaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguaugua- caga gguaauaaagcaauugagucccuggcugcuaaggucaguggacccagu 93 AI787627 ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc acaaccacuaagcugguacccugaagaacu 94 M33988 gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa gggccauuaaaucccacuuccauaguuuc 95 AI845182 uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc cuugguuuugccugugcgcuuguca 96 AA619207 uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu auuacau 97 AW125783 cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa

98 J04103 Sequence below. cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgc- gccgggac cgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaauca- agaacau ggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgaug- gcucucu guuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucuccc- augacuc ggccagcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuuca- guggcuu ccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggc- uucucug ggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaacc- ucggcaa ggagcgcuuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaag- agaacca agaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacau- uaggcuuc agcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugccc- gccaucgg ccacgccugcagcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuac- uguucca ucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucu- ccagagaa cgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguac- agcggg uaccuuccuucgagagcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaag- gacuaca uccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacugga- agcggac caauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggg- gaugga ugggaguucaagcuugcugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaa- cuacgag aagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacgugua- ccguuuc guaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauac- agaagac ugagggccuca 99 D90146 Sequence below. auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcgg- ggucgg gagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgag- cccugcuc cacucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggccca- cacucgcu gcgguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacg- acacgca guucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggc- cggagu auugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagc- uacuaca accagagcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccgguga- ggucccg ggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcggu- gggggg guggggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcug- ugacau gggguccgacgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacg- aagaccu gaaaacguggacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagaga- gagaccg ggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugc- aggggcc gcgggcagcuccucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggug- ccccugg cucagaggggagagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcuca- gccuucu cccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuuca- guucccc uguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacu- ccugucc ugcugagugugucagcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacac- uaggcug guucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccu- uugacac ccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucu- uguguuu uuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucg- gcacu ggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugu- cguggaa cucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagug- cugggau uaaaggcuugggccaccaccacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaac- cauccag aucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagag- acagggu cuucugcaauccaggccugagugagagggaagaccacacacccugugagcccacuguguuccagugagugcugc- acugggg uccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggggcugggagucauu- uucucug gcugagugucagagguucaccacauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaaug- uugguc agcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuua- gauacga acucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaa- caucaca uaaggaugaccauguugacccacuggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugc- aguccug ugcugagggggccagcucugccugcaggucacuagugccaugacaguuaaaguguucauacagacacauaguuc- auuguaa uuacugauuuagcguugucuuggcaguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuu- auuua augcauggaaguacacuguugcuguacugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuu- uuuag gaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccu- gcuuguu cuggcccaaagauuuauuuauuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaagaggg- cgucaga ucucauuacagaugguugugagccaccaugugguugcuggaguuugaacucaggaccuucaaaagagcagucag- ugcucu uacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagau- cccccaa agacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccu- guugaca ucacccugacuuggcaguugaauggggaggagcugacccaggacacggagcuuguggagaccaggccugcaggg- gaugga accuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccauga- ggggcu gccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcau- ucugca gacucugagcuggucagggcugagagcugggaucaugacccucaccuucauuuccuguaccuguccuucccaga- gccuccu ccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugu- gguggc uuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaa- gugugc ucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucugg- gaacuuc caagaucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacugugcuccagcuccagg- uuagugu ggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguaacuc- uuccag agaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuug- gcaggga cagcuccuagagcucugauagaucucucccaggugguaaaggugacacucugggaccugauuggggaggggcaa- ugugga uaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagu- gaugg gucgugucccuc 100 AI563854 uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga ugcaguccaacaaagacauugaaaaugacuu 101 AF017128 Sequence below. ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccaca- gaggu ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagu- gguuca gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaac- gcggacc cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccg- uacggu cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggg- gggggg accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagc- agcau cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaag- gggac gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuu- cugccc cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccau- cccugc cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggg- uccau cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugu- cccuu uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuc- cugga gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgac- gucucu cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgcca- gggga gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccu- cccuu ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccaga- acgggg gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggug- cuucc uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagccccc- accccca ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauagg- aggcuuu uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagc- uaggca ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaa- gugac uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagcc- gauuaaa acucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaa- cugag acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucug- gugcuac augucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugag- aucc ugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagc- ugaaagu augcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucu- ccugu cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauac- uugau uuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaa- aucacac agcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacuga- gguga agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuau- cucuca gaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugg- gaccca cuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccua- gggccac cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguaggggu- ccuac uagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagg- uaaaa ggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcgua- uggaa gcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagca- ugucu ccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaa- caguc acggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuuca- gcacug gggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaagg- cuaca gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucag- aggaag ugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccug- agguc uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagug- agcuga gaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucu- ugag agccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuagg- ccaua gcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcugggu- guaccc guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaagg- ucagcc ugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaa- gaauaug cuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagccc-

ugcacu caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauau- gugaga uuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugag- caagag gcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguug- gagcu gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuc- cucac augugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaa- ucuca gcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcac- ugaaugc acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggg- uuucu cuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccug- ccuccc aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagu- gcuuc cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcuggg- auuug aacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaauc- uuuuuu uaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucu- uguua uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuua- cccgc ugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccuggagagauggcucagccgu- uaagag cacugaaugcuuuuccagagguccugaguucaauucccaacaaccacaugguagcucacaaccaucuguaaugg- gaucca augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaa- agccag gugguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacag- ccagg gcuacacagagaaacccucuaaaaaaccaaucuauguagggggugcuggugaaauggcuccguggguaaaggua- cuugcu gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcua- ugacaca cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugacucua- gccaggca uaguguggcacaugccuuuaaucacaguacuugggaggcagaggcaggugaaguuugaggccagccuacagagu- gaauu ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaa- gcuggaa gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucagggguuucaggccggucu- ugccu auacacugagcuaaaggccagccugggacacaugagacuuugucucuuuuaaaaagacaaaacaaggggguugg- uuagau ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcu- cacaac caucuguaacgaaaucugagucccucuucuggagugucugaaaacaacuacaguguacuuacauauaauaaaaa- uaaaua aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuggucuauaa- aucaagu ucaaggccaggcagggcuacucagagauucugucuaaaauacaaagaaacaaaacuacaaaaagcagaaaaagg- aaucuac gaaagggcuggugaagggguguaacucagugguagagcauuugccgagcuagcauguaccaagccauggguuug- auccc uagcacuaagcaaaagaaaaguccuacaaagggcuuuguuggcauaguagauugauucccaguagcuuuuggca- cucaag agcaccuucuacaauucacagcuccugggggaagaaaucccaucuuccacagaugaggaggcugagaguccugu- gaaaag agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccugggguccc- aacauc uuaguccaguccuaagaugcggaagggaggaagaucaaaguuuacagagagggaaagcauuucaggaaagaaac- cagcag uaaagcuaggugugugugagcuggaaaugucaccaaugagaugacaagcguccgguacagagaagcaacugugg- agugu ugggugguggcaccuagacuacagacugaaggaaagcuggaugaccagcucagggcagcugguggcucagaguc- agccu cauugucucccuucuucuaucccaaccuagaucagcccagaggaggaagagcgccgcagggugagacgcgagcg- gaacaa gcuagcagcugcuaagugcagaaaccgaagaaaggagcugacagacuuccugcaggcggugagcaucaucccca- ggcccg gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaaauuacuccucaggacucugu- cauccuc ccugccuguggggaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgggcuucgaggcag- agucg aagaugguaggcagcaauucuccuaagaugcccccgucugaugggagucauggccauuuucucccagaggcuca- cggga gggaguugcaguccagacuuguuggggaugacaggcacagucccuacuccagccugaggcuuggggaucuuuag- ccuuc auuuuccuaucuuucugcuaauccuguaaaggagaccgacaaauuggaggaugagaaaucggggcugcagcgag- agauu gaagagcugcagaagcagaaggaacgccuugagcuggugcuggaagcccaucgccccaucugcaaaaucccaga- aggaga caagaaggacccaggugguucuggcagcaccagcggugcuagcagcccaccagcccccggccgcccagugccuu- gcaucu cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacu- ccuuuua cuccgagucugguuuucaccuauccuagcacaccagaaccuugcuccuccgcucaccgaaagaguagcagcagc- aguggc gaccccuccuccgacccccugggcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcuggu- gcuacu ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuua- ucucuuc cgacuagaacaaacacauuaugcuuugauguagagccagcuuggaggggauccccaaagcugcucacuguuuuu- cuagag cuggccuaucauaauuugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagac- uuugua gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguua- uccagc cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagca- gcaccgg acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacu- cccuag cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagag- acuauuuuuaua caaaccuuccaaaauggaauaaaaggcuug 102 X67644 Sequence below. ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuuguga- cccaccu aguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggaguguc- ccuaag uaaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacgga- ggcag gcagagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuu- ccugc gcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggagggug- gcugga ccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuua- cccacaa gcauucacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuu- ugcuuccu ccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggcccc- uucuuug gcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugc- cacucgc gcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcgg- ggcucugg ucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcg- ggcaccg aaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcc- cuggaac uuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccag- cuaccaa ccgaggaacccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccagauuuugauggcu- gaagagg gugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacu- gcgcccc cgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaa- cauccgg cggccuucuaaacgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaac- guauccc aaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggccca- cuggggac ggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggaggggugua- uguaau auuuauucuaacuuaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagg- gucggu aagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaau- aagau uagggguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauc- cggccu uugaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcuguc- ugggg ucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaagu- guauca uucag 103 AF064088 See above (same Accession Number). 104 AI843085 uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagau guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca ucacuaaccccuuuuuacauaccgaauucaagucacuac 105 AW124932 cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuu uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc uggcgguacuccucgugccgaau 106 X58609 augg cgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccg gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggu gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc gucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggag aaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac guccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuuc aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc gggaaggagacgcugcugcgcacag 107 M18837 Sequence below. auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccg- gguccg gagggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacc- cuccgcc ccuucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucgg- ggucucac cgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagcc- ccgguuc aucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagcc- gcgggca ccguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuu- ccgagu gaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgacc- ccuccacg ucccaaaacaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuu- cccuuuc aguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucuca- cacuau ucaggugaucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacg- gccgcg auuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaag- ugggagca ggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagc- ucgggaa ggagacgcugcugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccu- ggggaa gaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucauca- cagugac ugcacugacucucccagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauu- ucccuga gguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucag- cccacug ucuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacug- aucggag acauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagauccc- ucccuguc ugugggguuuccaccccuucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggg- uacccug gaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuu- cuucuu cuucuucuucuucuucuucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucuc- ucucuc ucucucucucucucucucucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacuc- acuugu agaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggcca- ccuugcc cagccuuucuuauuuucuuuacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucu- uuug ucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaa- guuaag acaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacau- ccagaag ccuccugcucuuccucugucccacaaguuacagugcuccccccccccccccagugaaucuggacuuggacucug- agagacag ggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagug-

cugcacu gggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaagu- cauuuuc ucuggcugagugucagagguugacaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguu- augcua guuagcaagaugaacacagugguuuacgucucaguugucacacccuuccaguggcauauggcucuaauuucuac- uuuuga uacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaac- aucacaua aggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaaugugcagc- ugaggaa accagcucugccugcaggucaccagugccaugacaguugaagugucaaacagacacauuguucagugucaucag- ugauuua acugugccuuguguagauuucagagggucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuu- uugu uuuguuuucaagacaggauuuuucuguauagcccuggcuguccuggaacucacauuguggaccaggcugaccac- gaacuca gaaaucugccugccucugccucccgagugcugggauuaaaggcgugugccaccaccaaccagcuaaucgugaga- uuucuuu cuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucu- gugu aucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcucc- ggagugc ugggauuaaaggcaugugccacuaccaaccagcuaauugugggauuucuuaaaucuuccacacagauccuccaa- aggcaca ugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuucuacccugcuaaca- ucauccu gaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggauggaa- ccuucc agaagugggcaucugugguggugccucuugggaaggagcagaauuacacaugccaugugcaccaugaggggcug- ccugag ccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuugcag- acccug agcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccuccuc- cauccac ugucuccaacauggcgaacguagcuguucugguuguccuuggagcuuggccaucauugcagcugugguggcuuu- uguga ugaagagaaggagacacacagguaggaaagggcagagucugaguuuucucucagccuccuuuagagugugcucu- gcucauc aauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuuccua- gugucaa gcucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacuaugcucuggcuccagguua- gugugg gggacagaguuguccugaggucauuggagugaagcuggaguuguugggugcucugggaacccauaauagcuucu- cuguu guaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagggaca- gcuccc agagcucugauauguuucucucaagauuguaaaggugacauucuauggccugauugcagaggggcacuguggac- augguu guguuucagggacucccacaauccccugugagugguggguuguugggauauugucuucauuguggugguuccug- acccu cauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauuuuuc- uuuaga gaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccuacac- accagga ccugucucuugcauugcccuguguucccuuccaccgccaaccuuccgggucugcag 108 AW124268 uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccu cauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaau uaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc augaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacua auccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaa auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg auagcucuucagggucuccaguggc 109 AF090738 Sequence below. cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcg- uccucuc ccaaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccagcagu- aaccugg gggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagc- gaugacu acaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugccc- ccuuccgg agcagccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcu- ccccagcg gagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagaccc- uaagcua cuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagc- agcuuugc guggaggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcuccc- uguuccu gcagcggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggag- ccccagg ccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuucc- uccauga ggccgagugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccua- ucgcua gagggacugcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacau- caacauug acuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuuca- cugcucu cagcuaguaguccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucucca- cucucuga cuauaugaaccuggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcucca- uggaugg ccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuac- agcagccu cugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcugg- cuccucaa uguccuccgagccuggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccu- aucgugg caccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucag- guaucug ggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagaccca- caggggg gacgucgucgccacaguucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccac- aauuccaa gcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggag- gugauga gccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaacc- ccggucag cccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaa- cggccuc aacuauaucgccaucgaugugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaa- cuccugg agccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggagugugugggggucc- aggcac uggagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucg- ugaaagg ugaggcccuuugaccuugaggaugggggagggagaguggaguauuggguggcu 110 AI834950 uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg cgggucacuggucgu 111 AI851365 uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaa u 112 AW047339 cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc uuauccaaguucuauaugg 113 U06834 Sequence below. gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucgga- ucgcauu cagccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaaga- gacccug uugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcu- aagcggc cuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacg- cuucacc augauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagag- cgaacgu gauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaaca- ucugacuc ggaagcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccug gguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugca- ucucuuu uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugcc- gguggca gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaug- ggcugag cagcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaa guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaa- cagccacu cgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguuca- ccuugca cuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcu- ccccuug aguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugccc- uguggg ggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccuga- ugucacc uauaccuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaa- ugucac cacugaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugu- caugggc uauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggcccca- gcagugu ucguuuccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagg- uacgcgc acgguccgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcu- ggcggga gcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguuc- ucugc cucaggaagcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguac- caagguc uacauugauccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccua- ugucaag auugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaagga- gagcug uguggccaucaagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccauca- ugggcca guucgagcaucccaacaucauccgccucgagggcguggucaccaacagugugccgguuaugauccucacggaau- ucaugga gaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcuga- ggggcau cgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuugguca- acaguaa ccuggucugcaagguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaa- guucccu gggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaug- ccuggcg cuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggauguga- ucaaug ccauugaacaggacuaccggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacugu- uggcagaa ggaccggaaugcccggccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagcc- ucaaaau cguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguu- cuguggu cgaguggcuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugaga- ugguca gucagaucucugccgaggaccuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagu- gugcagc auaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaagg- acucacc accguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucac- agccuuc ccauuggauugcacuuugaacagagggggucggagacacagauuuggggaaccgugccauaugggaucauacau- gugccc uccaggcggggaaccccaaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucua- accuccca ucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggug- accagccu gccaacuugggaguggaaaaugccgucccaggaggcaggaaggggcugucaggacccggugauguaaucauugg- guuuug auguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuuca- uauugaa gguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccaga- uuuugu guguuaaagggcaccugguuccacuaucuccuguugggaacaaggacccaucgauauguucuagaacagugccu- uggaaau gcca 114 AA980204 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg

ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 115 AI843232 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 116 U59807 Sequence below. augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcu- gggccca ggucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguc- cugcagc ggguuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccggga- acugg ggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggaggg- auccggu ggucccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaa- gagaaagc cagacugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacu- gauacca ccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugu- gccuaguc ugaaacgaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaag- guaggg ggagguucaggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagc- ccaggacc cuguccacuaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagc- uccaug agacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagca- cucaggag gcagagacaggcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacaua- gugagac ccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccauguccc- ccggaau gaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucaccc- accauc caggugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagaca- gauagug gcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagagua- gagcaga guguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguu- aggguu cccggccuuaaaggaggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuuc- uaaggc uggguuaagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguu- ggugga gauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuauca- gaccaaca aagaaaggcacgaugagcucuccuacuucuga 117 AI152659 gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac cacuguguggaauuauaaauacaucccaugugca 118 AI850090 uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa uuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugug ugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugu gcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuuc agguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaa u 119 AF064635 See above sequence (A1850090). 120 AI843106 uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua aaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgag gucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca uu 121 AF033186 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 122 Z50159 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 123 X78683 Sequence below. gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcug- gugccg ccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggcc- ucggggc augggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccgu- ggaagg cggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuuca- ggauccc cugguuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaag- accugcag auggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagg- gcuggac uaugaggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgca- gcugau cacccagcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucaucc- uggauga uguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcagg- aagccca gcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcgg- aggcug ccaagaugcuuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaac- aucucuaa aacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguu- uuacucgg ggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcaca- cuugucca gcuuggaggagccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguauc- ugcccuc uuggauuaaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcggggugg- acaaug ugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc 124 X68193 acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccaga uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga ccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccguggu ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagac caauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac augaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucauc ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa aaaaaaaaaaaa 125 AA062013 uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacug cgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggc caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga accuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugau uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac 126 AI465965 auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac 127 U50413 Sequence below. ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaa- ggaaccg ggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaag- cccaggc ugggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacag- auggaca gugugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugc- ugagaa ggacacgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagaugg- acagca gccggacggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggau- uuuagc ccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagg- gcacuag agcugcagacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagaca- uugaccu acaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagccc- ggccuga agauauuggcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaau- acauug gaaggaaaagaauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuuca- aaaacuga agcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgc- cucuccu uauaaagcuccuggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagca- acccugca gaauuacgacagcuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcaga- ugcuuu caaacgcuaucucgccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagccc- aagaacu acagagcccugaagacugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggc- uuacgcu ucaguauuugcucaagcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucu- cugagau uuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagaga- uuuuaau cucaacggaauggaaugagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagcca- acaacagca ugaacaacaauauguccuugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaa- cuccgag acacugcugaugggaccuuuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuagg- aaaggag gaaauaacaaauuaaucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucu- gugguug aguuaauaaaccacuaccggaaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuaccca- gugucca aauaccagcaggaucaaguugucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacu- caauuuca agaaaaaagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaa- cggcuauc gaagcauuuaaugaaaccauaaaaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacau- agagaagu uuaaacgcgaaggcaacgagaaagaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagu- gagauca uugacaguaggaggagguuggaagaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaug- aacagua uuaagccggaccucauccaguugagaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcgg-

cagaaga agcugaacgaguggcuggggaaugaaaauaccgaagaucaauacucccugguagaagaugaugaggauuugccc- caccaug acgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggc- acuuucc uuguccgggagagcaguaagcagggcugcuaugccugcuccguagugguagacggcgaagucaagcauugcguc- auuaac aagacugccaccggcuauggcuuugccgagcccuacaaccuguacagcucccugaaggagcuggugcuacauua- ucaacaca ccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgauga- agcgcugc ccucggauccaguuccucaccuucaagccacccaaggccucugagaagcaaagggcuccucuccagcccgaccu- gugaacug agcugcagaaaugaagccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucggggaagaca- cgcagcc ucggacuguuggaugaccagacguuucuaaccuuauccucuuucuuucuuucuuucuuucuuucuuucuuucuu- ucuuuc uuucuuucuuucuuucuuucuuucuaauuuaaagccacaacacacaaccaacacacagagagaaagaaaugcaa- aaaucucu ccgugcagggacaaagaggccuuuaaccauggugcuuguuaacgcuuucugaagcuuuaccagcuacaaguugg- gacuuu ggagaccagaagguagacagggccgaagagccugcgccuggggccgcuugguccagccugguguagccugggug- ucgcug gguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagag- ccgcguc ugcucacgcaggacacuuugagagaacauugaugcagucuguucggaggaaaaaugaaacaccagaaaacguuu- uuguuua aacuuaucaagucagcaaccaacaacccaccaacagaaaaaaaaaaaaaa 128 AW120502 uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggaggg cauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucu uuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuu ccuuugaagauucuccugg 129 X62940 Sequence below. agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcu- gcagacag cuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacg- gggcug uuuuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuacca- acugag acauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucug- gugcaa gugugguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagg- gaggaa guggaaguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcu- gaagacgc uggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagcca- caggggac cacacagcccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacu- ggcugcug cugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauu- gcugucu acgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuug- aagaaau guacuaguugagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucug- aggaau gguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgg- gcggcuc gccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccu- ucaaag aacucggagaggccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccga- caacugu caccaaagcuuauaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugac- acaacggu gacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguagugua- acgaa uuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugu- cugaaa agguguggcuuguccuuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuu- uaagaau uuggcccaguuagucacucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugacc- gauguca guuaagcuggugauaccuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccuc- accugu auagucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaa- gcauauc aaauguugau 130 U60020 Sequence below. auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcuccc- gggaau cuucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuag- gacuag ggguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgca- cugagu uuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcugg- auuacu guacuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcaca- aguuggg gagccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccua- agaaga gacgucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggc- cgcauc acugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccau- agccagca cagcgcuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagag- guguuuc gggccguccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugag- gacacag ccaacgugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuug- guguuc auguuuugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaa- gcuggg aaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccu- uaucggc gaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaauga- agacgcu aaacaagaaggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugg- gaauuc uguaccugggcgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccag- cuucag uucacccaggcuguucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaau- auucgaa uacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguu- ccaagau gucucuuuugccuacccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaac- ggugaca gcguuggugggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgg- gggccag cugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggaca- agagccg cugcuauuuggaagaaguuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucac- agcugug gccguggagucuggagcccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugg- gaacca gcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuugg- augaug ccaccagugcccuggaugcuggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucu- cggacgg uucuucuuaucacccagcagcucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucuguc- ggcgagc agggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugca- gacuga 131 L32752 gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug accggaauuc 132 AI840013 uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc accuugcuugcagaguagugcacucuucagcguugacugcguagagcuuuucuuucucau uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau 133 AB020424 ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu aagaggagggcgagcugucucgcaau 134 AI848453 uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca aucanacgguggguu 135 AU040563 cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc agauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugc uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc ggcacgcaggugcngcg 136 X89749 Sequence below. ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccagggga- cugucca ugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaac- acucucu uguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcucc- uagaaac cccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcag- ugacucu gaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagagg- caaucug cccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaaga- gaaagcac ugcugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuu- ccugacau gcugagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcu- cuauuga agcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggaccca- acccaacc cuagggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauac- cacugug acugcauugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaau- agcaccc agcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagag- uggucuuu ucaacacuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugca- cucaaacg agcggcagagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauac- gguccuga uugccgggggugauggcaagagaugcauuauuuuauauauuuuuuc 137 AW125390 uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug ggcauguugaucacaguaguucugacagaagccga 138 X05862 Sequence below. aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggag- aggcaaag ccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccu- uguuagg uccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcuc- uuaaaag agccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccu- ccgaca ccgcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgag- cgcuug uuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcc- cauggcc uuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcg- gcugcg cuugcgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcgg- acuug gcgggcucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucug- gcugcaa

uuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaaggg- auuuucaa accagggcgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauau- acuaugc guauacguuuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacgug- gcaagc aaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgug- caccggc ugcuccgcaagggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguac- cugacg gccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugca- gcuggcca uccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauc- caggccg ugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaag- gcucuuuu cagagccacucacuuucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccu- uccuccu auuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcac- ccaacc ucggaccuaguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacag- accggacu gcacaaagaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaau- ccucacuu gaauccuguuuauguggcaugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagc- auuuggu gguaucacagcuaaaac 139 AW046181 uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu cuaaaaauagaaauau 140 U10118 Sequence below. gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaa- ugaugc uguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcuc- uucuua aggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaa- gaaauaga agagcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuc- cacugca gacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaag- agcagau caaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucgg- cagcagca aguacugacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagca- cccugau gcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaa- ucaugu uccucuagaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguuc- ugucuc aagccauggugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggg- gacagaa uuacuuuugaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccag- ccugacc ugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcaga- gcccaaa ccauggccaauaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaaga- gaagugu guuuaucacuuacauau 141 AW212775 ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca aagcagcccuuagccuccccgacccccuuucccucccucccagca 142 AI846302 uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg cacuuugcgcucauccacugcagg 143 M22998 Sequence below. acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccguc- ucgcag ccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucaugu- uggcugu gggaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauug- aggaguu cuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucu- ccguggcc aucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuc- caugcu gaugaugaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugc- ugaucc ugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagagguguca- ccuaca gcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuugg- cuuaga cuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacagugua- uccuguu gcccuucugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcuga- agaagcu ucgagggacagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaaga- aggucac caucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagc- agcuguc ggguaucaaugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgcca- ccaucgg cuccgguaucgucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugc- accuca uuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuugg- augucc uaucugagcaucguggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucau- uguggc cgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuuca- uugugg gcaugugcuuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcuc- uucuuc aucuucaccuacuucaaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggg- gggugcc agccaaagugacaagacacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccaca- cccagccc ggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagau- cucgggc aagccgggccugggcgccuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccaga- auuuuua augaaagcaagacugcugcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuugu- uauuuu uuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugagggugggg- accacgc ccuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauacc- gaacucu gagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggg- uccggac uccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccag- uuggaag cacuggagugcagggaggagagggaagggccaggcugggcugccagguucuagucuccugugcacugagggcca- cacaaac accaugagaaggaccucggaggcugagaacuuaacugcugaagacacggacacuccugcccugcuguguauaga- uggaaga uauuuauauauuuuuugguugucaauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuugu- aaauaca ccaacaaacuccuguaacuuuaccuaagcagauauaaau ggcugguuuuuag 144 X64837 Sequence below. gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaa- gcgacac ugacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucu- gcgccga ggaguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccga- guacauuu uugaacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauu- uauaugu gggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccaccca- aagauca uagaugccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaa- uacgagg aguacaucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugca- uguaagc ucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaac- uuuugg ggucgaacacuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccagg- cuuugaa accaucccauauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucauggugga- gcccauc cagggugaagcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcacca- gguccug uuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucag- accuga uaugguucuucuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaa- ugcug accauuaaaccaggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucu- ugagguu uuagaagaggagaaucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcc- cucugac guugugaccucagugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuug- gaaggu gugccugcgacuucgagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccucccc- uugugau caaggaggaugagauccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucu- ggggagc caucuucagacagggcucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuuca- guugau gcauaauagagugacaccuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucu- cuuugu ugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugc- agucau uuacgugcgucuuuacaguuuccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacaga- acaguu aaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuu- uucauug gccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuugua- aaacauu uauuuucaguauuucuuugaauaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuug- guaaua aucaguguauuauuucauccugaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuu- uauucu aaauaaagcuaugaccaguuucugucugu 145 AI843119 uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu uaggaccauuagaucagau 146 A1837786 uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca 147 U41465 Sequence below. ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugu- gaagcaa ggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguuc- uucucaa ccuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagccc- auaagac agugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaauca- aucuaga uccugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaag- gcaauau cauggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaagg- ccaguga agcagaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugaca- ucauggcc uaccgaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugc- uccuccu cuguacaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuu- cucugaug aggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagu- gccaggca agucccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgccca- aggaggc agucccagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcuc- ggaaugc uccauacuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauu- ucgagcc ccccaaugcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacu- cacccaca gaguccugcagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugaccc- gaaagccu gcaacuggaagaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcag- gcagagcu gggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugauc- uccagucc ccgaccaagcucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacag- gucccugg gaggcuccccccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggc- ucucaguc

cccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucag- aguauuc ggauucuagcugugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcuca- agaggc acacgcugcagacgcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaac- cucgccag ccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagcca- accugaag acccacacucgaauucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggc- ccaccuc cgugcccacgugcucauccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccu- ucagacu cugaagagccaucugcgcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucguca- caaaagcc aacugcgacuucauuugcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcu- gaccugcc uccggagcuccccaaagccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucaga- aucuaccc aaaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucau- aguuggg guggggguggg 148 U70494 ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaa 149 D17666 Sequence below. caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccacca- ugauaag cgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccagg- ugagaag cugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuag- gaaaaau ccggagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugug- cugagu cacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuug- aaugugc cuggacuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacu- aaag cuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccc- caggau ggcuggaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguu- ucucug agaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguu- uauucaa uaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuu- cauuucu uacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuau- ggaggg caaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauagga- augcuga gucggagcccagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccu- agagua caaagugagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaug- cuga aggugccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaac- ggcaagc ugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguac- agaaagac acgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucugug- gaucac cuuggaucacuuuuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuu- guuauu ucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaa- cuca uucuguagaccaggcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaa- guuu cacagggauaguuuacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccucc- aauggu gaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaa- agagac ugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauu- aacuuc auauucuguagauaauggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugc- cucc ugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggcc- ucucua cauauuaagccacaaaggagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugc- cuuuuu uuuauuuuccuaacaugguaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagca- aaaaaug cugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggagu- ggaggu gggguaccugaguuaaaggauggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccaga- uaucug ggcuaaaugugcuucgagugaucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagau- aaagugu aaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacu- acaau uuguguggguccguguguugugguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnn- nnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nn nnnnnnnnnnnnnnaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugaua- cguua acaggcaugccacuuagguugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaa- acuuuug gucuuuuaauucguuccuuuguuuuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguau- gauuu aggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaaugggg- acacuu ucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuac- cacugc uuagucaccacugguuaagguguaggcguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuug- uuaau agcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucu- uagauug ggaacaaaagaccaagugacaguguuauaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgc- agu cuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguu- cgggaag cugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcaua- uuugaau aguguauucuaauuuaccuaaugucaguguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagc- aaagga acaacuugaugaucaguucuuuucauuugaaugaaugaaguagauuuauggauguguguaucuuuugccugcau- gugug ucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguugggga- nnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nn nnnnnnnnnnnnnnnnnnncacacugagucuaaauucugaucaugucuuucagucguguuauguuacuuugagu- gagua ucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggau- gcuucug gaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacu- auugcuc cgugucagaaagcuaugcaggaugcagaagucagcaagagugacauaggagaagugauucugguugguggcaug- acaagg augcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcuu- guguugu guguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcu- uuuaguc gccugugauggcucauguaggaggauggccuugaguucuggguaagaugcagcuacagaauucuaccuugcaca- cacacu uaaacccagucugguaaagagaaguuguuaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagauguaaaauugaua- auac uucuuccuaagauugggcgauuguguagaauaugagaacuguauuuuauaaccccuugucaugugccuucuauu- ucaaau gauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguu- gucaaa uacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcucca- ucaguc gcccuggguguuggcuaacagguucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggca- gagccc cgaguaaagcuguuaauccugaugaggcuguagccaucggagcugccauccagggagguguguuggcuggugac- guuaca gacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuau- uaauag gaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguu- guacaagu gcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacugggugnnnnnn- nnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nn nnnnnnnnnnnnccuagguguuuucuacugcugcugauggacaaacucaaguagagauuaaagugugucagggg- gaacga gagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuuu- uggggu cuauagcuugcaaagcuccaaacugcugacauuacaggcauauuguguuauuuuuuaaaaagaacguuauguac- augaguu augaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguuuucagaauuugaaauuuucaaagccuggga- aauguu cagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuacu- gguucug gucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauaaccaucaugguuauuaacuu- cuugaa gcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaaucucaagguuuugaacauucagugaaga- uacuuguu uuaggaaacaagugguuaguuggccugauuuggaaaugagaauacaugggccuuucaaaggagcucacucugga- uauuua uuuuagauuggaauucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaaugg- gauugu gcacguuucugccaaagauaaaggcacuggucgugagcaacaga 150 X14897 Sequence below. auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcu- uggucac auuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuucccc- aguccuua uuguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaa- gaaaggag ccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaau- gaaucuu ccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaa- aaugaaaa gguuugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauuc- acuugcaa auuagcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaa- uaguuuua gaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuu- gaaaccu auuaaaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacug- uguauga acauguuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacg- ccuaggca gcaagcacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagc- gcacgcu gcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagc- cuggacu uucaggagguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcagu- ucuccg aaccggagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuc- cacucgg ccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcu- uuucccg gagacuacgacuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacucc- uucggca guccacccaccgccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacgguc- accgcaau cacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagc- cacuggcc ucccagccuccagcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacag- cacuggcg gggcaagcggaaguggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagcc- aggccua gaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcug- gcugcagc uaagugcaggaaccgucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaagg- cagagcu ggagucggagaucgccgagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcu- gcaagau ccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaagg-

aagacgg cuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaacc- ugacggcu ucucucuuuacacacagugaaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccuc- guuuguc cucaccugcccggaggucuccgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcu- gaacucgc ccucccuucuugcucuguaaacucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagau- gaggagga gaggggaggaagcaguccggggguguguguguggacccuuugacucuucugucugaccaccugccgccucugcc- aucgga caugacggaaggaccuccuuuguguuuugugcuccgucucugguuuucugugccccggcgagaccggagagcug- gugacu uuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucu- ggggau agauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaag- ggugc ugaguguggggugcaggguggguugaggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacag- caccgu ccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcuc- ccucggg ccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugaggga- agucgau gcccccuuugggagucugcuaaccccacuucccgcugauuccaaaaugugaaccccuaucugacugcucagucu- uucccuc cugggaaaacuggcucagguuggauuuuuuuccucgucugcuacagagcccccucccaacucaggcccgcuccc- accccug ugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuac- ugguuuu gggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucggauugcuggg- ugcgcc ggaugggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccu- ugacagg gaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuua- aguccuu cgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaa- uuuucaga gaaguuuucagggcugaggcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcaua- cuuaaga gggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccucca- gcuuucac cucgugagaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgug- cugcaug gaacauuccauacccuguccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccu- uuccuggu ucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcg- ugcgug cgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucag- acuuu cuggcugucccuuuuugucaccuuuuuguuguugucucggcuccucuggcuguuggagacagucccggccucuc- ccuuua uccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccggunug- ucuguua auucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacaauc- uauauc guugagaauuc 151 AJ006289 Sequence below. caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccug- ggccaug gaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacgugu- uuaccug ugugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacuga- agaaauu ucuugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccugga- cacccug guggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucg- gaauaua aaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucuc- uaggugca auuccgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagc- acggcucc cuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuu- cagccac ucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguugug- gaaacu caagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuac- uagugau gcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuu- uaaaauc aguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucauggu- ggucgu gacuuuuccauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaau- uuuau cggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauu- uucagu cugauuguuuuucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgg- gaaagc ugccgacacacucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggca- cugagcc uggugaccucagugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuug- uguccu cagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaa- aguccu cgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacagg- augugg ccguggccaguguggcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaag- uuugac uaacuuuacacauuuuaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacu- ccuauuu auuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu 152 X12944 Sequence below. ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaagg- agacaaa accaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcc- caaaccua aaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcg- aauaauc cugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugug- ugcauuu uugauaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaa- uuucgu uuuacuuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucau- guguca guaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguug- gcuccca ggagagagauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaa- uucacuu uuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggc- ccccaaaa uugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuc- cuuuua uaaaagauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaaca- acauccu uaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguu- uuauagu ggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccaug- uccug ccugaauaccaugauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa 153 AW061302 uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg auuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgu cuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguu gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc gcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcug cucaaagggcgacaagcugua 154 U67328 Sequence below. caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauucca- acaucuc ugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugc- auccuaa cuuugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguaugug- gagcacc ugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugagg- agaucu gccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacu- ccuccuga aggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugu- gcaagua caucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcucc- acucccgc ugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugca- gauccugu auaaccguacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacu- ucuggau auucagucaagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucag- gaacag gaaaagguagagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucu- gguguca gcuaugcuccuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguu- ccaccacc aacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccucc- aaggcca ugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuu- uucccug aggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuac- agcagug ucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucauc- agcaaga ugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagccc- ucugccc agcaagaaacuuggcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuuga- ccaaaaa cagggaaccuaugguggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugg- uggcuac ccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuu- ucuccuaa cucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaa- aaaaaaaaaa aaaaaaaaaaaaa 155 AI604314 uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga gcacuucauuugcuuuuagaguauacauagacu 156 AI845121 cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagc g 157 AW047756 uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca cccuucaccagucagugucugaucugguggag 158 AI838021 uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc uuucagugucggugucagaaguccguuuucaa 159 AW122893 uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc cuucauuuucuugcccauuuugguaccccucgugccg 160 M59821 Sequence below. gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauu- cucgacu uaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaaga- uguacca cucucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgag- agcucua ccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacc- cgccgcgg gaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagagga- agugcug cgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcga- uuugagc gacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucgga- gguucc cgaucgccugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcu- ucuccagu cuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggc- cgacaaua ugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccgga- gcggag aacgcacacccgaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggc- aaggacu gaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuug- gcuugg

agaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuuca- cuaccau ucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugc- uuccug uugccuugcguggguguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuuga- gucacc ucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggaga- ccccggg acuggucaaccuagaugaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccgu- agacac agcuucuucgggcaggaaagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacggu- ggguug uuuaauuagcaacuaccuggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu 161 M13805 See above (same Accession Number). 162 AI845886 uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug ggucacugcgaaaugcagcaauuuagu 163 X53157 gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc 164 U19118 See above (same Accession Number). 165 AF062071 Sequence below. gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcuca- ggagacu aaccagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaaugug- uucugu uugcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguucca- acagucc uaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacau- cugaaaa aucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggaca- aaauaacu accccgaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucuca- aagugaag aaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggg- uuugacu gccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagca- gaagcug cagcaaaaaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacauguga- agagacug aaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguu- cuccag aguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauugg- auaga uacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacac- auauacua ggaacaaaauuuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuug- ggaaugu aaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggac- uggcagu cuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacuggua- uuuggua ccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaa- cugguuc uaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccaga- agauauc ugcauucucauuacuaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuu- gguuuuc acauauagcagcucuguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuuca- ugugcau cuuuuguugaauguuuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacugua- cccuuc ugcauggaaaaucauaaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcug- cuuuauc auauuguacuuggguguaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguaca- auaaca acuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuug- ugaugu augaaacuuguguuuuuuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucugua- aauag uuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacau- ugaguu uugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauug- cacaua aucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa 166 U10404 augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa 167 U07634 Sequence below. cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggau- cgcggg gagcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcgg- ccgcg gcggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccc- cuaugg caaagggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguau- ccggcga ccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguuca- cggugcg agacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagaug- uggacua uggcaccaacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagug- acuucgag gcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuu- ccaggac aucggcgccugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggc- cugcuu ccccgagaccauugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaug- ccguggu gccuuaugggggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugu- gccagg aaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagc- ccuuccc uggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagg- gcaccug aggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaa- guagaacu gcguuggacagcucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcg- cagaguc uggcgagugugggcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgaguguga- cagucag ugaccuggagccccacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagcc- gaagcuu ccggacugccagcgucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccuccc- ugaguguc accaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugc- caacagc uauaauggccgccgcacggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugca- ggugcag gcauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucg- caacaug gcggugaucggcgguguggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucg- aagga ggaggaaccugcgggcucgccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaag- accuaug uggauccucacacuuacgaagaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccugugug- gcaaggca gaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggaga- uaccgg uggccaucaagacacugaaagcgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaug- ggccagu uuagccaccacaauaucauccgccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguac- auggagaa uggagcgcuagacaaguuccuuagggagaaggauggugaguucagcguacuucaguuggugggcaugcugaggg- guaucg cauccggcaugaaguaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaac- agcaaccu ggugugcaagguguccgauuuuggccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaagug- gcggca agaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagc- uacggca uugucaugugggaagugaugacuuauggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagcc- aucaacg acggcuuccggcuccccacgcccauggacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaa- gagcgcu cccgccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacg- cuggcuga cuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacgguguccg- aguggcu ggagagcaucaagaucgaacaguacacggaacacuucaugguggcuggcuacacggccaucgagaaggugguac- agauguc caacgaagacaucaaaaggaucggagugcgucuuccuggccaccagaagcgcauugccuacagccugcugggac- ucaaggac caggucaacacaguggggauuccuaucugaguccauuggggcugucacacaauacuugaagagccacagugguc- ucccugc cgaucuggugcuggcccacuggaacuuuauuuauuucuguuuccucgucuaugccucccuaggacucugcaggg- gcuuuu ugaaugacaccugccugagccugggaaacuuggauugcuggucagggcucucuuuccccugaaaaggacccagc- uaagaac uuagcaguuugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucgauaucgacgagggac- auuucca aacggaccuccccaucuucauuuggccuccugagaagccacucuggagcugaggcuaagcacuaagcccaggac- cauaugac uagcacuguaccgcccgccccuaguuagaggguagguuuuggacuuggcuggguuguggucacaagcaaucucc- cagugc cuuuuacagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuug- gcugugc ugagguuuuuauuaaauauauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcugga- gacaga ggauccccugcaacaagacauucccgggcugggggcuggcggaccugcaggagacuuuccgccaccaccccguc- uccagccc cuuuggacaaaugucgcugucaguguuacagauuucuuuuauuggguuguuuuuuuguuguauuuuuuugaacc- uuaac uuauuauuuuuuuuauauuuauuguuagaaaaugacuuauuucugcucuggaauaaaguugcagaugguuca 168 X04663 Sequence below. ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccgu- agccauga gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgau- gaacaug gcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaa- gccacagg uggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuu- uuggcc agaucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacaca- gagggag cugaguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucag- cugac ccacucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccug- accguau caugaauaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugu- cugucca ucaguugguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguaccc- ucaagcu caccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguu- ucccgggc cagcuuaaugcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccugg- cuuugcc ccucucaccagccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugc- caagaaca ugauggccgccugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaug- aaggagg uggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaag- acagcug ucugugacaucccaccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcug- uucaagc gcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggac- gagaug gaguucaccgaggcugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcgga- agaggaa gaggauuucggagaggaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagauc- ccucagc cuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuuc- ucauu ggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg 169 X61232 Sequence below. ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcu-

gugugc cgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggc- gccgcc ggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucg- guauggc ugcagugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgag- cugucug acaaccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguu- ggacggg aauugcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauc- cacagca cccgaauucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaag- gacuggu uugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguu- aaugaga aagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugccccc- gagaccaa ggcugucauucacuggaucauggacauuccauuugugcuuucugccaaucugcacggaggagaccuuguggcua- auuacc cauaugaugagacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuug- gcucgcg cguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagc- uuugaug auggaacgaccaaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagc- aacugcu uugagaucacuguggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaac- aaaaacu cccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaau- gccaacg caaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcu- ccugga aacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugc- uguuggg guggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaau- gauguc agaaacuuugaauuuuuaagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaau- guggcuc uuuucuuuuagguugugugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaauca- cguaaa uacacccggacagaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucu- uuuaacgu aaugggugacaaugucacuugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucac- auaguuc cauauaaguuguccuuagucucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggauggga- agaaaa uguacgugcuuuucagaggggcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauug- uauuag ucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg 170 X14309 Sequence below. gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucguguc- accguuu cugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaag- cagcccau gaaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacgg- aggccg gggucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgc- ugggcg cugcugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcg- cugcc gugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggc- cgggau gcgggaggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuagg- cccaau ucacaagaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaag- auuuuaaa gaccuucuacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaa- ugcguggu uccucccugcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacggugug- gauggu uuccaauuccgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaa- cuuaagu gaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccag- cgaccug cuguugaccagcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuu- gaaugcc acuggcagccaauggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucu- ccgacuc uaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugc- ccuucc uggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagcc- ucaacaug acagugaagggccagaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaa- ggagcgc ucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggacca- gaaugag cguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcugg- cauaagc cugccagccagcgcuaaacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaa- gcuggaa aaccugagccugaauccuuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaac- cuaccac ccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacaua- cgaauu cuuauacuggguguuuuugucuucaaauaaaaacaucaccccugccucaug 171 U42386 Sequence below. gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnaaau- aaauuu acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccau- aaauaaua uaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaac- gucuuga agcauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuaucc- uggaua gguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcau- acauuca aagcacuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuau- gagcuag ccaaaugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucu- acuuag acuuuuuaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuag- ggcucug gaugauuuuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauua- ugcagc aggcuuuauuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauaga- cuuugu aaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaau- auguacaua acugaacaaggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuua- uagucu guuuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguua- auuuugu gaccagaaugcagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagug- caauaga uuuucaaguguauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguu- auggu gcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauug- cacauu cagagaauuuuauauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguu- gaacgc agcuugucuaggaaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaa- cuuugc acacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuau- uuuugu aagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaau- guugaaug ucaccguaugcgugaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagu- caaauu aagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaa- aucaugc caagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucuca- gauguuu guugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacauguggu- uaucu uuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauau- uuucag uuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuag- uaguug cuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaa- cugcac agucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaa- uaugua cauaacugnacaaggugucaauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguu- uuuaun gncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccugg- guuanuu uggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaa- agugnaa uagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncau- ugguu auggugcuauuuccanuuagucuagguuuaggcccu 172 U51126 Sequence below. cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuu- gaagagg acuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucacc- ucuacaa ucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuugga- aggcgau uccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccu- gccgagac acaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccac- ggcaaugu gcgggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguuga- ucuuugu cauggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauaugg- accaca uagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagag- acagaaa ccaccaucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccagucc- guguugg gguccauugucaacgccuucaugguaggauguauguuugugaaaauaucccaacccaagaagagggcagagacc- cuggucu uuuccacccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaau- ucucac auuguggaggcauccaucagagccaaguugaucaaguccaaacagacuucagagggggaguuuauuccccucaa- ccagacu gauaucaacgugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuagccaugaaau- uaaccaa cagagucccuucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggaggg- aauggu ggaagccacagggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugc- uggaucu uggguccaugaacugcuuuuauuugcugcaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagac- ucagagc cugaaggauaacacgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcgucca- ggcuuag uuucuuccuuuguuuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguu- ucuuuu cagagcuguaagcccagugcccagugaccucaucugggaggagaguuaagcaauaagaccugaaaugcuaaacu- cuggggu agaaaaccucugcagagacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucag- agucuua cuuccauaccuggagaaauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaag- acacugg uaucagcuaucccagcaguaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaa- accuaugg ucuucaacagcuggggagccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccu- ccucguu gaaaagcaaaacacuguaagaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuuggucc- acaaagag cuugaggucuugaucuggaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccaua- gcucuga augagguaggcagauuccuggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaa- gaacaaga gguggauccugagaagcgacacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgg- gacacaca cucgcaauuugcaaacaaggcaaauucucacacuucagaaggcacugagagaaucccauaagcucaaaaaguua- ggagccaa gauugaccauuaaugacuuggguugaaaagacuaaaccacuggauagaauguuucauuacuaaaacaccuuacc- ugaaaag uauuacugcucuucuuucugcaacuggaccaugcagagauccacaaagagaugcccagagauuauuagugaugg- ucauaug auauacacaauguggacucuaagccaaggccccaucaacucagauccagaggcugacagugugcuuaucuuaga- gauaccac aguggcugccuaaucaccacguccuuaagucaggggaguuugauuauuuccuaugaacaccgaguggggacagc- ggauuac caaugaagcaauccaaccugacaauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuacg- ugucaaca ugugcacacuccggccacgcagcucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuau- gaucucg ucuguuguguuaauuacccagcuagcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucugug- uccucuu uaauuucaacccacaguuacaucauucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugau- gaugccu cuucccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucu- cauaggcc acagggugaaaugcaauaaagaacaaagccuuguagggaggcagagggaaagaccaguccucacaagaggcucc- auuguuu ccagggacuuugaagcuuggacagaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaa- uauugac ugaugugugcccguccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauauuu- gaaauaa uaaggaacacuggagccggccagaaaggauucugcagucccauaaauagcaacauucaucacuacaaugccugc- caacggug gccgugaauguagauuacccccggcucuucugaggccacugaggacagggcaaacuaccucugagaauggaggc- ucacugu ucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaaccu-

ugugcua uuaaccaaaucauuuugaauuccauaaaccucuacucuaaaguauacacuuaauucuacaauacagacaacaaa- uaugacuu uuuccuaugaaagagugauaaagauacuguaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaa- aaaaaaaaa aa 173 AF093853 Sequence below. uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaug- agcug gaguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauac- aaaaauau ugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaa- gccagguu cacugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggac- gaagccc ccaacuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucuc- uuuuccc acccacgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaag- aggaaug uuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaau- ggugaa acacccacggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguu- ggaucca gucgagaaggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaa- gcugucu auccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacagg- cacaaag ccgguugccaccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagc- caaacaa uguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuua- agucuuug cggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugca- gcaggu ccguagaaagaucguggcaugaucacagccgguccuguagaucgcucgcuauacuacugggucauuaaauggaa- auggcac caaaaccuucucgggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacu- gacuggc ucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagug- ucagug ugggcucugugcuagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggaga- gcacug acauggggagaagcuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaa- ucuauu guaaguuucuaucgaagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuucca- caucugc ucucuggugaugucugccugugaacgcaccuuauaaaagacgggcggugacaguguuuuaccacucaguguccu- aguagu ggguggccauuucugaauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaa- agccaaca uucauguggaaacugaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacu- uuuuaga guuuaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacuca- uagcccug agugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcuc- ugcaaaaa aaggaaucaaauucacccaagaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaaugga- aacaaaaag aacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagcca- gacucacu agagggcacagggacagcauccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaaga- aauccaaaa caccaccagauccucuacaaaaggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagac- aga 174 Z19521 Sequence below. augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaaga- cucagg cagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagu- gcccgga uggcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgug- ucagccg augcauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcugucccc- ccaagac gugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgag- auugcc uagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccaua- ugcauccc cagucuuugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccg- aagacac ggccuccaaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgca- gcugggu cugugacggcgaggcagacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaug- aauucca gugugcagauggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacg- agcucgg cugcgucaaugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggaca- aggugu gcgacuccgcccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggac- aacaaug guggcuguucccacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguuggug- gaccuc cacaggugugaagauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcag- cuacaag ugugagugccaggccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucu- gcucuuc accaaccgccacgagguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaa- uguggugg cucucgacacggaggugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccug- auggacca ggccccuaacuuguccuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacugga- uccaccg caacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacac- uguucca agaggcaggguccagacccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaa- cacccgc caagaucaagaaaggggguuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaaug- gcaucac acuagaucuuuccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaug- ggggcaa ucggaaaaccauuuuggaggaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaagugu- auuggac agaugucauaaacgaagccauuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaacc- ucuuguc cccggaggacauuguccuguuccacaaggucacacagccuagaggggugaacuggugugagacaacagcccucc- uccccaa uggugguugccaguaccugugccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcc- cugaugg caugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccg- ccguccg gccuguggucaccgcaucagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggc- agccugu ggacaccccagggcucagcacaguggcgucagugacagugucccaccaaguccagggugacauggcuggcagag- ggaauga ggagcagccacaugguaugagguuccuguccaucuucuucccuauugcacugguugcccuccuuguccuugggg- ccgucc ugcuguggaggaacuggcggcugaagaacaucacaaucaacagcauaaacuuugacaacccagucuaccagaag- accacaga ggacgagcuccacauuugccgaagccaggauggcuauaccuaccccucaagacagauggucagccuggaggacg- auguggc augagcagccgggagagccgucucuuuccgggauccauugccaagcuuaggcagaaaagacacucucuccagac- cuccccau ccagcacugguccugccaccucccugggucuguguugcucaaagcaagauagagcaaagcugggcuggggggcc- aagcuca gcuuccugucugccccagguucuguuuuauauauuuauugucugggacagaaaaggcuacuggcugugcuugaa- auucga 175 U04354 Sequence below. accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcac- cauggcg caggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcu- ggaacu gguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaagu- ccagcag gggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucu- uuacgg uccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuu- gugggc uauuucaaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucu- gacugcg aaaagacuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaa- caagggc gacugcuucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucu- gaaagca agccagguggccauuggcauccgggacaaugagaggaaaggaagaucucaacucauugugguggaagaaggaag- ugaacca ucagagcucaugaagguuuuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcaga- cauaagu aacaggaagauggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaaga- aaacccg uucuccaugggaauguugcuuucugaagaaugcuucauuuuggaccauggugcugcaaaacaaauuuuuguaug- gaaagg uaaaaaugcuaacccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauu- cuacuaa uacucaaauucagguucuuccggaaggcggugaaacaccaauuuucaaacaguucuuuaaggacuggaaggaua- aagacca gagugauggcuuugggaagguguacaucacggagaaaguggcucagauaaagcagauuccguuugaugccucaa- aacugca caguucuccgcagauggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguag- agaaca gugguagaguccagauugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacu- uauccca gaggacagaucaucuacacauggcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacu- guccagu uggaccggucccuuggagggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugagu- uuguuc aaagacaaaccacucauuauuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacg- ccuuuuuc aaguccggaggaaccuggcaucuaucaccagaauuguggagguugacguugaugcaaauucauuaaauucuaau- gacacuu uuguccuaaaacugccacgaaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaagga- gcagagu auguggcugauguccucaagugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucu- cuuggag ggaggggagacuaccagacuucaccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugc- uccaaca aaacuggaagauucauuauugaagaaguuccgggagaguucacccaggaugaccuggcagaagaugaugucaug- cuacuug augcgugggaacagaucuuuauuuggauuggcaaagaugccaaugaaguugagaaaaaggaaucagugaagucu- gccaaaa uguaccuggagacagacccuucuggaagagacaagaggacaccgauugucaucaucaagcaagggcacgagccc- cccacauu cacaggcugguuucugggcugggacuccagcaggugguaaaaccagcaacuauccuggcugcauuggggcagcu- gccacuu uguuguuggggaauuguuuacuuuuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuau- aucuau aucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuauc- uaucuau cuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguaug- uuacua uacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuu- gucauuc agccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgu- cugcuac ucuguuugcagugagcuuuacuuuauguauggcuuuaacaaugccuugcuguuucccaucucaagucaaugcca- cuugga ugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuu- uaugaua aaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcau- ugaauga uguuuuucauaauuaaaauauauccuuuugg 176 M35244 Sequence below. caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacugg- aagaauu uccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuua- aaauuca gauugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgc- ucuagu uuauaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucu- ccugcag cuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcuguguc- ccggccu ggccuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaagga- ggagac uccgaggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauuc- aaggaca gcugucugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacagu- ggcugca ggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucucc- ccacccu gagcgaaaacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacu- gcucagau gugcugcagaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccg- ucacccca gaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcag- aaggaug gggaggagcugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggca- gcugug guggugccucuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccu- gagaug ggagccugcaugguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucu- gugug gcucgcagacccaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacagucc- ccaagacu cuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucua- ggccac

uccccaggaacuucaggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucu- ugccacc cuggacagaaacacaucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuaguc- aggcauu uugucaccuugucaagggucccagggacacaaagcucccuccucucacccacagcacucuggguccuaccccca- augcuuca gggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggg- uuuaau aaaaaaaauaucuuuuu 177 AW121930 uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucuggg ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau caucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagc cucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaau cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucau cacaacugucuguggugggacgggcccuccagucugugucuguuuug 178 AI852632 uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaa acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc agcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcagg aaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagca gcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacac caagauggagcccacgaagagauuacaucaagcucuucuggcuggg 179 U70475 Sequence below. ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuu- uauuugcg gaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaag- gggcgg gggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaau- ucccag caaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacugua- uacauaa uaaauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucug- uuguuu ugcagucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagu- gaaugg aauugacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaa- cccgug uggaccaucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuu- ggaggc aagacauagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaa- cagaaaa aacucgaaaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacuggau- gaagaaac aggagaauuccucccaauucagccggcccagcauauccagacagacaccaguggauccgccagcuacucccagg- uacacucg ucguggugggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuac- uguguc uuuugugaggaggagaaguucucaaacuucgcuucuugauaaucaggacacagaucacagggaggacuuuguga- guucag aaacauccucuguggugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugug- guaggca gggcccugauuguauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaaca- acuaaag cauuugcccagaacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccac- gcuguuc guuaaaggggagggacuaauaauuugaacacaaucugguuugaaucuaugcaaaucgauuucugaaaugagacc- auagguu auuuuaugaacaagucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccu- uucccc uuccuccagguugcccacauucccaaacaagaugccuuguacuuugaagacuguaugcagcuuuuggcagagac- auuccca uuuguagaugaccaugagguauaaaaauguuuguuuaacagcaaaacucccuuaucugauauuaguuccuuuca- uguguc uccaauuaagagaagaaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugag- agcuauau aaugcuuaaaaauaagaccuguaugggcuggugagauggcucaguugguaagaguacccgacugcucuuccgaa- gguccag aguucaaaucccagcaaccacaagguggcucacaacauccauaacaagaucugacucccucuucuggagugucu- gaagacag cuacaguguacuuacauauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaagucca- uuuuacug uauagcuggaaacaggaaucagaauaauuuucccuggaaacuggauauagauauauaaaauauuuugacuagua- aagaaca acuauuaaucagcauuuggauuaaaaaaucuuaaucuguuguuugaagcauucugcuagauauuauggguacag- auuaag uccuaaugaauguuuuuauccauuuugaagucugccuuuaaauacauggagugaaauaaccuaggaguguauua- auaugg agucacugggaggaggaaauguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucu- ucaugc cuuggcucucacucacaugaaucaaugucacgucaaucuuggcuuucuucacuugcauuucagucgcuugcccu- ggauauc cccagccacgcugaaaguucagucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagc- caugacug auuuaagcagcauagagcaggacauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaaga- gagcucu aggagugugcuguuuucugcgggcccuuuuaaauuagucauccuaguuauuuauuauuuacaugcuaccuccuc- aaagga agaaauugaugguguauuuaaauuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaau- cagacug aauauuucuggauaaauucauucaaagacugaaagcuaauuuagaguucugacaaagauaaaauacuuaucuau- ugaaaaa ugggaguugaaggaauuauugaaaagaacaccuuggauuuggggguagggaauugaucuaaaaugcacuuagcc- ucugcu cauacaaugugaccuucuuuccuagugucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguuccca- gcccagaa gccacacugacagaaauggacagcaauuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaa- cuguggu ccacauuuccuucaugguuuugaggauucuuucagcagcauccucuccacugaugaugccagccagcugaccuc- cuuagac ucaaaucccaccuuaaacacagauuuuggcgaugaauuuuauucugcuuucauagcagagcccagugacggugg- cagcaug ccuuccuccgcugccaucagucagucacucucugaacuccuggacgggacuauugaaggcugugaccugucacu- guguaaa gcuuucaacccgaagcacgcugaaggcacaauggaauucaaugacucugacucuggcauuucacugaacacaag- ucccagcc gagcguccccagagcacuccguggagucuuccauuuacggagacccaccgccuggguucagugacucggaaaug- gaggagc uagauagugccccuggaagugucaaacagaacggcccuaaagcacagccagcacauucuccuggagacacagua- cagccucu gucaccagcucaagggcacagugcuccuaugcgugaaucccaaugugaaaauacaacaaaaaaagaaguucccg- ugaguccu ggucaucaaaaagccccauucacaaaagacaaacauucaagccgcuuagaggcucaucucacacgagaugagcu- uagggcaa aagcucuccauauuccauucccugucgaaaaaaucauuaaccucccuguugaugacuucaaugaaaugaugucc- aaggagca auucaaugaagcucagcucgcauugauccgagauauacgcaggagagguaagaauaaagucgccgcccagaacu- guaggaa aaggaagcuggagaacauugucgagcuggagcaagacuugggccacuuaaaagacgagagagaaaaacuacuca- gagaaaag ggagaaaacgacagaaaccuccaucuacugaaaaggcggcucagcaccuuguaucuugaagucuucagcauguu- acgugau gaggauggaaagccuuacucucccagugaauacucucugcagcaaaccagagauggcaauguguuccuuguucc- caaaagc aagaagccagauacaaagaaaaacuagguucgggaggauggagccuuuucugagcuaguguuuguuuuguacug- cuaaaac uuccuacugugaugugaaaugcagaaacacuuuauaaguaacuaugcagaauuauagccaaagcuaguauagca- auaauau gaaacuuuacaaagcauuaaagucucaauguugaaucaguuucauuuuaacucucaaguuaauuucuuaggcac- cauuugg gagaguuucuguuuaaguguaaauacuacagaacuuauuuauacuauucucacuuguuacagucauagacuuau- augacau cuggcuaaaagcaaacuauugaaaacuaaccagaccacuauacuuuuuuauauacuguaugaacaggaaaugac- auuuuua uauuaaauuguuuagcucauaaaaauuaaaaggagcuagcacuaauaaaagaauaucaugacuuaaacuacuuu- ggacuuu uugaauuuauucacacuauuuuccauaggacaaucacucauuuaccacauuugguuauuuuacauuuucaaaau- ggguuu gaaaauacagaggcauuuuauagccauguguggcaguccaugauuuuuuauucccgacauucaggaggcagaag- caggcag aucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaac- guuagcua ggauugucaaggagaugguauauauccacaaugguaugccugcuguacaguacuguggcacagagaacaaaacc- uguaacc uccuguguucuuagaaguggcauucuaagaagggcuaggaaga 180 U09659 ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcgguggug gcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugac agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca gaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaa ggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucuccca gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc cauuccacugaugucugaacuauuucaucauguaaauaauuu 181 AW124785 uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaag uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucg ucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccagugg acauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua aauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuu uuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua 182 AF071315 Sequence below. auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggc- gaaugg gagcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggagug- uuuccg ucgcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccu- augcagg ugauuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccac- accgug gaagagaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcu- ggaguuu cuggguugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaau- ugagagu ccgcucuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucga- uauaauc aauggagaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucggugu- agaccac guggcccggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugc- caucaag augcugcacagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaacca- ugagauc cugcgggaggccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuauga- ucaaugc aaugacguggggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaa- guucaacg uccucuacgaccgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggaugg- ugugug gggcucagacagcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccc- cuuaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaa 183 D49733 Sequence below. aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuu- cccgag guccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuu- gccauucc acucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccag- uggugg aaguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccuga- uccucuc ccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugc- ucuuuacu ccagaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaaggggu- guucugc agagugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuu- aagagca guggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaa- cgcugc cucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccagga- gcgagcuu cgccggcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugccc- agcgggc agcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcuc- uaccccac ugucgcccacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguac- aucgauc gcgugcguucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccga- gaggug uccggcaucaaggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcg- cgcccgc cuccagcuagagcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggcc- ggcacca gggaggcagcagucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggc- agugcca annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nn nnnnnnnnnnnnnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugca- ucauuc augucuacauaauuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugc- cuagcau uuacgaacuucgggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguaga- ggccgga ggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucau- gaauaaa aauaaauaauaaauaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagcca- gguagag gguugcagucccaggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggu- cuuuccg gaacuccugagggcgcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcg- gcaggc gggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugu- cccucc

cccaggacagggggaggaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugccc- ucuuc ugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaac- accaaga aggagggggacuuguuggcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcc- cugagca cugcucucagugagaagcgcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgc- uguccu gugaccccagugaccccaccugguccgacauaucauucggucccauuugccugcucaccuucacuucuccaguc- uagannn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn- nn nnnnnnnnnnnnnnnnnnnnnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccuccc- accucu ccaugaacuuggcuuucucccucucagcuugaggcggcccugggagaggcuaagaagcagcuucaggaugagau- gcugag gcgaguggaugcugagaacaggcuacagacgcugaaggaggagcuugacuuccagaagaacauuuacagcgagg- uaagcgu cccgcuguacaggucuuucuuacuguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcug- cccgug ccuggccgguggaguuacgacuucuggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucucc- ccuuaac 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ccccugugccccucccucuucaucgacaucagcccuugggagcucaucagacccuuugucuuccccgccccagu- uggcagcc aaggaggcaaagcugcgugaccuggaggacucgcuggcccgugagcgcgauaccagccggcgccugcuggcuga- gaaagag cgagagauggcggagaugcgggcgaggaugcagcagcagcuggacgaguaccaggagcugcuggacaucaagcu- ggcccug gacauggagauccaugccuaucgaaagcugcuggagggcgaggaggagaggugaacuaggaggggucuacagaa- cuuguc aggggccucuggccgcaacuaccaugacuaaccccgcaccgugucuccaccuuccccaggcugcgccugucccc- cagcccua ccucgcagcgcagccguggccgcgccuccucccacucaucccagucucaggguggaggcagcgucaccaaaaag- cgcaagcu ggagucuuccgagagccggagcagcuucucgcagcaugcucgcacuagcgggcguguggcgguagaggaagucg- augaag agggaaaguucgugcggcugcgcaacaaguccaacgaggugggccugugaaccaggguggucuuuucaguggcu- gggagu ucuugguucucguggagcaucugucucccuaucugagaauuuggagugugugguaguccugucaucuuuaaauu- guugg gaagaugcaugauauagggaugggugacccuugagccaauagucuagguuugaugccagagguagugguggaag- ccuguc uuucuuuucuuuuucuuuuucuuuuucuuuuucuuuuucucuuucuucucucuuuuuuuuuuuuccgauggggu- cuug cccagguuggcuuugaucucccuaguuaagcuguuccccugccucagccuccauaguagcuggaacugcaggng- 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gaggaugacgacgaggauggagaagagcuccuccaucaccaccgugugaguggcagccgccgcugaggcccagc- ccacaag gguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuuucauuaaagaauguuuuggaaug- ccacuug cugcccuggccuuucuucucucuccucccucuaccuugaacagggaacccaggugucugguaaggaagggagug- gggacu ugcugaugccauggauacuccacgguggcaguggacaggguucuggauuuguguccugggaaggggcugggagg- acagag guggccccagcccugccucucuuccucacucccauugcaugcacacuucucuccucucuccuuccacccuauug- caugcuuc uccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauuaagucucuccaucuuugcuc- uuccucu ugauugccccauaagugucuaagauucaggagagaguuaaagccacagcucuuuauuucgaaggcuuccuggcu- auuuccc ccaucaugcccuuccucccagccacaggucucccaaguccccaucacuugguugucuggguacagacagagguc- accuuccu gcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaagucagucccaaacucgcugu- cccuccug agccuugucucccuucccaggguucccacugcagcggcucgggggaccccgcugaguacaaccugcgcucacgc- accgugc ugugcgggacgugugggcagccugcugacaaggcugccgguggagcgggagcccaggugggcggauccaucucc- ucuggc ucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcaguggggguggcagcuucgggga- caaccu agucacccgcuccuaccuccugggcaacuccaguccccggagccaggugagucaucucugcccuacagcaggac- acugcuca cugagcagcagggcagggcagcccaagggaguggggucccccuccuugcagucccucuugcauccugccccucc- ugucuga accccagacucgaggucagggcaaggcccagagugugaggguuggggagacaaccccuuuggggucagggaggg- agagga agggccagccacugcugcucacaccucugccuucucuucucucuuagagcucccagaacugcagcaucauguaa- ucuggga ccugccaggcagggcugggggcagaggccaccugcuccccccucaccacaugccaccuccugucugcuccuuag- gagagca ggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuuucuucuauuuuuuuuucuuuuucuaa- gagaag uuauuuucuacagugguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuaucucaauccuaaguc- cuuccccu uucuuuccuuguaucugccuuaaaaccaaagggcuucucuaggagcccagggaaaggacugcuuuuuauagagu- cuagau uuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggcaggcauggag- uucucu ucaccagccuccuccaacagcuggcccacugccacgccagcugcagagaaauggggcgcagagaggaugacuga- gaagguca agccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuucccuagccug- gggcgag 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aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg cccacauggccuccaagguaagccccuggaccaccagccccagcaaggcacaagaggaag g agagacccu 187 AI839906 uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaac aaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucc cagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagg gguuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcu ugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaaggg cacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaa ggagaggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc 188 AI843448 uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaa aaaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugaga gucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccugg ucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaaga gggcaagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagcca uaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgg gugguaaacaccucccaccguuaggaaaaa 189 AW125336 cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaagucc uuuugcauccucggaauuccaggggcugaccacuuuuaaaccugggcagugcccauacc augcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccc cugaauacuaugggcaca 190 AW123802 uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuagguga ggccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuuguc uccagcuucgagcuugagacucucaggaggcuggcgauaggcagggaaagccucccagg ggcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuacc cgcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccg gaaaggaugucccucgaagccauaaucugucaggauccuucuuaaaucagggugguuaa aaaaaaaaaaaaaaaaaaaa 191 AI835771 uuuuuuuuuuuuuuuuuggggggcagcgaacuuuauugaugguauucaaaaaaauag ggagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugaggg aaaugcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcu ggggugggugguccaagguuucuuacuccuuggaggccauuuuggccaagagguccac cacccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugu cauugaaaaaaaugccaaccccggaaucaaagg 192 X53584 Sequence below. gcuccucaucucacucgggccuaugccaaagauguaaaauuuggugcggaugcucgagccuuaaugcuucaagg- uguagac cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaag- ucccaaa guaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcu- uguucag gauguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugc- caaggag ggcuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcugu- aauugc ugaacuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacg- gagacaaa gacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaa- aacccug aaugaugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacauc- aaaaggu caaaaaugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauuguccc- ugcucu ugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgc- ugguuuu gaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagc- uuaaaga uauggcuaucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcuc- augauu uagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucac- auugaaa aacguauucaagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaagaaaagcugaacgagcga- cuugcuaa acuuucagauggaguagcuguguugaagguuggaggaacaagugauguugaagugaaugagaagaaagacagag- uuacug augcucucaaugcuacaagagcagcuguugaagaaggcauuguucuaggagggggcugcgcucugcuucggugc- auccca gccuuggauucauuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaagagcacuuaaaau- uccugcaa ugacgauugcuaagaaugcagguguugaaggaucuuugauaguugagaaaauucugcagaguuccucagaaguu- gguuau gacgccaugcuuggagauuuugugaacaugguggaaaaagggaucauugauccaacaaagguugugagaacugc- cuuacu ggaugcugcugggguggccuccuugcuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaagg- acccugg aaugggugcaauggguggcaugggaggggguaugggaggcggcauguucuaacuccuagaguagugcuuugccc- uuauca augaacugugacaggaagcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacug- aagagaag gcuggcugaccacuguaaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauugucc- augccu acagauaauuuauuuuguauuuuugaauaaagaacauuuguacauuccugaugcugguugcaagagccauauac- cagugu ccugcuuucaacuuaaaucacugaggcaucucuacucuucugugagucaucaggacuguagcgcugugucaaca- aaacaua gagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaug- ugacaa ccuuuguguaa 193 M32599 acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuug- gccgua uugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauu- gaccuca acuacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaauggg- aagcuug ucaucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcu- gaguaug ucguggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacggguc- aucaucu ccgccccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauu- gucagca augcauccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaaggg- cucauga ccacaguccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccgu- ggggcug cccagaacaucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaag- cucacug gcauggccuuccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaag- uaugaug acaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguu- gucuccu gcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuuguc- aagcuca uuuccugguaugacaaugaauacggcuacagcaacagggugguggaccucauggccuacauggccuccaaggag- uaagaaa cccuggaccacccaccccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagca- ucucccuca caauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaa- uaaaguuc gcugcacccac 194 AF035644 agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu uuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccucc uccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaa ugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucaca accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa cuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaaucc acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcgga a ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagag g gaa 195 Y00629 Sequence below. auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgcc- acaguc ccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagc- gggagg guggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggac- cuugagc cugggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugu- cccggcc cggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacg- cggaaaa uccgaggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaag- ccaggg acauggggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugc- ggcuggg aucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauc- caaacgcc uacccagaaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuu- guuuug agauaucuacuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgc- ugcagug gauguacggcugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccagg- auuaca ucucccugaacgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagag- gcagucga ugaggcccaccaacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaa- augagac acugcagcgcucaggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguaua- accuca ggggcagaacgcuguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccugu- agggau ucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucagg- ccucccu ccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggac- cagaagc ccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaag- agcagau ccucccaggugcaggugcucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccac- cccagga cggucacaugaacacugcugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagaccc- uccaaagg cacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcu- gacauca cccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggau- ggaacc uuccagaagugggcagcugucguggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggg- gcugcc ugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucu- gcagac ccugaguuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagcc- uccucca uccacugucuccaacaugguaaucauagcuguucugguuguccuuggagcugugaucauccuuggagcuguggu- ggcuuu ugugaugaagaggaggagacacauagguaggaaagggcagggucugaguuuucucucagccuccuuuugcagug- ugcucu

gcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcugucaguuccgggaac- ucccuag ggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuaggu- aagugc gagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucu- ccucuu gccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucu- gacuggc cucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuucuga- aggucc agaguucaaaucccagcaaccacaugguggcucacaaccauccguaacgagaucugacucccucuucuggagug- ucugaaga cagcuacaauguacuuacauauaauaaa 196 AW125380 uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucu ucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca cgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcaggg ccggcgagcggcgggugcgccucgugccg 197 U68564 Sequence below. ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcgg- ugcug caaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaagg- agcauuu ccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggc- aucggcc cagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcaugua- agcucc aacgcugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacau- ugaaacaa aucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacguc- auccacugu aagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcga- guacagca gccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauu- gcugaau augcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacug- ggugaug gacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagac- aacacaac aaugcagcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaaca- acgucug ugcagggcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacag- cuacaa ggaacacaggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaug- cuagacca ccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcaua- ccccagau auuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggc- uguggag gcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuug- ggggac aggacccagaauaaagccacuucuguuccagaaaaaa 198 AW125346 uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu ucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacau uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc gugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacau gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu gcacuuaucccuucaacauugu 199 X61232 See above (same Accession Number). 200 D20333 gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn ncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauua uaaaaauaaaguauuuugcuaguauggaaa 201 AB025218 aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc caaauucaugauuuacu 202 U84411 Sequence below. gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccg- ccgccu gcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccgg- cuguauga uuaggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuu- cugaag ggcaguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuc- caccaaga aacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcuca- gaccugg augggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuug- uuuagg agguucauuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaau- aucgaag uagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugg- uuu aaaucauuucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacaugg- cucgaa ugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcg- accuuaaa caaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacua- cucuugu ggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaug- acuggcu aagucuugugaagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggca- gagcuc cggugcuuguugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaag- cggcgug gagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauucc- aaugguc auagaaacaacuguuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagauggg- accugau uugucaugcauauuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaacc- agucuua ccaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaa- gauuuuu gcuguucagcauuuaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuauguc- auuaaa uguacuccugugccagaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaau- acuugua uauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucag- ucauuuc aaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgu- cagguuu gcuuagccauccuuuauuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucuc- auuuu guuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccag- acaaaaa gccuuauaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagagga- ggcuauu aaauauuuuuaguaauauguugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuu- uuaaga cauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucagg- aaguuuc cagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagug- aacugag cagaaauguuuuauaacgccuuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuaugua- aucgga uaaaauggugauguguauuaaaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucug- uggga gaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaac- cgcauuc gucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaau- uuaugga aaaaauuguuaggguugccaagugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguu- gaaugu ugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcu- cugcaa uuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugagu- auuugg cacaugauggcuuaauaaauuuuaacuuuc 203 M62362 Sequence below. acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugg- gugacuu agaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcug- agcgcu gcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcu- cccgccc cacucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuuc- gauccgag acccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgac- ccgaagc ugcgcgggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgc- cgaggc ucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgau- gagcagu caccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgc- ccccagcc ccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgac- ccggccgc cuucaacgacgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggcc- ccgcggg uggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacg- ggcccc cucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcg- cccgcgc uacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuc- cccuacc agccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuc- cagaucgcg cacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgca- cgcugcgcc cgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccucc- gcacggg aggcggcggcgguggcagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguacc- ggguacg gcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacaga- aggugcug gaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcgggg- caucuuc cgccagcugccugagagcuccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuu- gggccg gcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccagg- acuagga gauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcguc- uaagau gagggagucaggccguggugguuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggca- guacua guauuaaggaaguaaccuugugccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaa- ugugccu ugauauuuuauuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcag- gcccag ggcaggaggaagauacaggaagcugagaucccggcagugcccugagcugccccucagucccugucuuuagaggg- gagggac uuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuu- uuugca ccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugg- gggcacca cccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuu- gugggg ugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaac- uugaag cacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauauca- acacuug uaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauu- uggucu uuuguuuuguuuugguuuugcucugauucuugccaaacugagacucuucacuaacggcugggggaaggagcuga- gugag gcucucauucuuuuugguuuagggauguuuggguuuuuucgucugccucccagaggaccaaugaaaugaagugg- gcuucc cccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuuccc- cacccac ccaaccccauccccaacggcccuggcucugggucuggaaagaaggccaccuccagccaguucauacacacaccc- cuguggcu gggagcagggcuggaccgcuuccuucucuucuuuuuuuggggggggggacacaaaguuucaugcuagaugucgu- augua uuauaucuauaauauaaacauaucaaacucaa 204 AA032310 gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua guuccuggccuuaguguuug 205 M94087 Sequence below. gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguau- uagagg cagcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccacc- ggccuaa gccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauu-

ccuggaa uccagcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugauguccc- ccuucga ccagucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaac- cucaug gguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacacc- ggcaagg aggaugccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuu- cgaaug gaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuagu- ccaagag acuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccaggu- ugcccccu uuacauucuugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagag- cuaggca gugaaguugauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccaugugua- aaggagg aagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagc- cccuccac cuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacc- caccugga guuaguuugacagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagc- agccacua gguaccgccagaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugag- gcucuga aagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagg- gggaaga agagaguuccguaauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaaua- aauua uuuuguagugaaagu 206 AI847609 uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuua caguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguuca gucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccuggu uu gggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauc cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa 207 AI853294 uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagu cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag ccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguau u aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu gcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugaguc c ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa gcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga 208 M33934 Sequence below. ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcgga- cuaccu gauuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggcc- ucaccua caaugauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacua- agaagau uacacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgc- uuacagg agguauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacg- aacaggga uucaucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcaugg- cuucugu gguauccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuu- ccucaag gaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgu- cacucu gaaagaggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugg- uagccau cauugcccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcugu- guggggca gccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuu- ggacuc uucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacagguca- uuggaggc aauguagucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaag- ugguuc caucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaug- cccgucg cuuugguguuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuugggg- cuucca cagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccgg- cugaaga aauaccgagguauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcu- gacaaaa ucaaaguggcccaaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauu- gcuggca uccagcauuccugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuu- aaauuug agaagaggacauccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucuga- aaacaga uccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaa- aaaaaaaaa aaaaaa 209 X16202 gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga aagggcagagucugaguuuuu 210 AI661431 acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu 211 AI839109 uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga gcauucgguuugac 212 AI849135 uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa aaaaaaccauggcgccucgugccg 213 M32459 gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca ccacccgacgaagcagucugag 214 AI841389 uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu acuu 215 X03039 Sequence below. auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaagg- cgucauc gagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuua- ugccua ugguuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcuc- aagccc agucugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacu- caggcuu ugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggu- gccucu ugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucau- cguggg uaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacugg- augaagc agaugaaauguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagg- uaguuuu guugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuug- ucaaga aggaagaauugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacaca- uugugug acuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucacc- gagaaga ugcaugcccgagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagg- gaguucc ggucuggcucuagcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuua- gucauc aacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggg- uguggcu auuaacauggugaccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaaga- gaugcccc ucaacguugcugaccucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccuggggugggg- cuaagg aagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuug- uuuca guuuuuuuucucuaugaauaaaugucacuuuuugaggc 216 AW049795 uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc caaagaagucggcaccgcauga 217 D87691 Sequence below. auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauu- guauuug ugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaau- agacgg aaguggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaa- agaaacac ggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaagu- agccgag acugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuu- uaaaac ugaacuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaug- guggug aaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaa- uuaauag gacgauauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuug- gaaaug ggagcuguacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacaga- agaggag aaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaaca- cgaacuga uagaaagcaugccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugucaca- gauaagu cacaagaaggaucacaguuugugaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccag- ggaaug gaguaccaaggaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgu- gccucac ccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuc- cagaacuu aauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucgug- gugucag cgcagcagccgacaacuaagucucu 218 AI117211 cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag 219 Y00520 ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg gaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucgu ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu

cgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaa ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca cuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucuga cggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcu u 220 AA638002 uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga cagugaacagaguaug 221 Z22661 caugggccuccugagaga uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu uugaccaagacccg 222 X99644 Sequence below. cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugc- cuggcc guuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccaccccc- ccggcgg cgugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucuggua- gcccagg gucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgu- cguccc cugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgag- cgggau ccucggcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaa- uucgggg gauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacau- cgugga gaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcu- gugaag auaaugccccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccag- cgggug aaauacaccaaggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacug- uaaugugc acaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcu- cacaagga ccaucaguaccaguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuug- gggacaa acaugccacacuucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgag- ugcaggu ugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugccc- agaagg ugaccgagggucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacac- auuuugcg uuuugccucuugggcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagc- ugcauc gggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccugg- accaag agugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcucc- uccaaga gccccaggcccucuaagcaagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugg- gucagau gaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaagugg- ccucuu aaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuuca- aggucuu uccuggaagcacuacugaggacuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucagg- cuggga cugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcu- gcuauug gagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugcc- gagggac cucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguggcuccugagguuacuucagcccca- guaagu gggccagguauccuggaugacagugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaa- ccagugc gaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacu- cugccac gugcucccugaccuaaaggaggaagauggaagccucagccuggauggagcagauagcacuggugugguagcuaa- acucuca ccagccaaccagcggaaaugugagcguguucuccuggcccuguucugccaugaaccaugccgucccuugcauca- gcuggcu accgacucuacauucuccauggagcagccuggugguacccuagaccugaccuugauucgugcucgccuccaaga- gaagcug ucaccuccuuauagcuccccccaggaguuugcucaagaugugggccgcauguucaaacaguucaacaagcugac- ugaggac aaggcagauguucaguccaucaucggcuugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacac- caaguuu ucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggccc- uggugau ggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccuguc- cuuugg uggccugacuccuguucuugcuggccccaucguccccucagucccucuucacaaaaugguuuuuacuucugugg- auuuaa uaaaaacuucacugagucaguuaaaaaaaaaaaa 223 AI843895 uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa 224 M38724 uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga ucg 225 AW122989 uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc 226 AI844810 uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca cuucacuauaaagaaugaacaccaugacauccucgugccg 227 AA940430 agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag 228 M38381 Sequence below. aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuuca- ggguug gaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggaga- agcagca gcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaa- acgacaga cagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacagga- augacua caugggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucug- guaggag uggaagaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagaguc- accgaagg aaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaag- auauga aauuguugauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagac- guguag caguaaaaauaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuug- aauacaa cagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauugug- uuugaa cuucuggggcuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaa- gauggc auaucaaauaugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaaca- ucuuauu ugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagaua- uuaaagu gguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcac- cggaagu uauuuuagcccucggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuug- gauuua caguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcac- augauac agaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauau- guuucuc ggcgcuguaaaccucugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauuggg- aaaaug uuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaa- gcauacgu gauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuugua- uagcuu aauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaa- uuauaga augauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa 229 AF014371 ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau uacuggccuuucauuuaucuauaauuuaccuaaga 230 Z30939 uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc 231 U28208 uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag 232 AV218217 ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu

[0216] Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.

Example 9

Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells

[0217] The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.

TABLE-US-00005 TABLE 4 Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase as determined by quantitative real time PCR. Gene Name/ Protein name/ SEQ GenBk Fold ID Acces #. Incr. Sequence No. Cell surface proteins Cd34/Cd 34 43 uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauaca 233 antigen (189) cccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagau AI847784, caggaccccuguucuccccuuaaccccaggagaggaagcuuauagucuu AI173145 uguagauauucugaaccucugaucacaaaggguuauaaaauagugaagg gguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacug aggccacagcucccccaggagucagaggaagggggaagucacguauuuu auagaaggccaagggccucagagcaagaguauuccuuugaagagcuca Calcium-related S100a4/ 35 ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc 234 S100A4 (144) uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca (mts) aaguucggggagagguggccucggacgccaagagcuuugugcugaacc X15986 ugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaau gcccauggagacgccaacaccauuguguguaacaccaaggaagauggga ccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggag caucacagaggugugcaucaccuuugaccaggcugaccugaccaucaag cugccagacggacaugaauucaaguuccccaaccgccucaacauggaggc caucaacuacauggcggcggauggagacuucaagauuaagugcguggcc uuugagugaagccagccagccuguagcccucaauaaaggcagcugccuc ugcu Transcription Factors and related genes Id2 helix- 11 (25) gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauu 235 loop-helix cucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuu protein uuucuuuucuuuuuacuuucucuuuuucuuuugcacaagaagaagucu AF077861 acaagaucuuuuaagacuuuuguuaucagccauuucaccaggagaacac guugaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugau cgucuugcccaggugucuuguucuccggccuggacugugauaccguua uuuaugagagacuuucagugcccuuucuacaguuggaagguuuucuuu auauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaa ucacaaggaauugcccaauguaagcagacuuugccuuuucacaaaggug gagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucu ucggucagaaauggccuuuuugacacgagccuacugaaugcuguguaua uauuuauauauaaauauauauauauugagugaaccuuguggacucuuu aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaa aauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaa acuuaacccuuuuauacaaaauaaaucaaguguguuuauugaauguuga uugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuuaugcu auguuauaacugaacccaaauaaauaccaguucaaauuuauguagacug uauuaagauuauaauaaaaugugucugacaucaa Id4 4 (12) cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc 236 AJ001972 gggcugcggcggcggggagcuggcgcuacgcugccuggcggagcacgg ccacagccuggguggcucggcagccgccgccgccgcugcggcggccgcg cgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugc agugcgauaugaacgacugcuacagucgccugcggaggcucgugccuac caucccgcccaacaagaaagucagcaaaguggagauccugcagcacguua ucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuu gcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuu guccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccg gugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggg gcggcgagauacggguggucuugcuccucucagggaaugacagccgcu ucucccgucuccaccgagagccgccugcugggcuuggugauccacuggu cccugagccgagggcgguugggcuuggagcccugcgucuccggagugu cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacuc ugcucaccugccuaguuuuccaggacgucuccugggugguggcgacac ugugauaugcgcacucuaaccgcuuuuccccuugguguuggguugcug uuccaggccggcgccgugaacaagcagggugacagcauucucugccgcu Peg3/ 12 Sequence below. 237 Paternally expressed gene 3 zinc finger protein AF038939 acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaa- gugggaga gaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagaga- uguggag ccucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugau- gucaaga ccacauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgaguc- auaccag aauguuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcu- gcucucgc ugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcu- gccuaccc aagcaccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacg- agucuucu cauggagugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaa- cgagcgu ccuccuccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugaucca- ggagagg gguuaugaagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuaga- aaggaag aggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuu- ugagug uggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucg- auuuug gggccaacccauacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagauc- augcac acuagggagaaccucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaaguca- gggugg ggggaaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaa- uccaugc uagagaauaucuugcagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagc- ugcagaa gauguauggcaaagauaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauug- agcacca gaaaauccaugguagaggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcac- gugcacg agagcagcgugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacu- ucaauga guuucggaagauguacaggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucau- cccuga gggagcaucagaaaauccauacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuuguc- ccuaguc agucucuccgacggcgccagaaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaug- ggaaacu cagacuccagcgagcaucagaaaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuuc- guugaau cucagaagagucauacuauaacaagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaac- ccuaaugac aagcugaaacuccccaucauggaaaauggcucccagggcaaauccugugagaggucuguuauucauagcuuggg- cuccgca gaagcucagaagagucaugguggacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcuc- aagcagc auuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauag- cuugccag cuccucgaccucugaaacgucauagagcaaaugaccauauucaaugugaugaggggggagaauccuccauuuau- aucccag auauuauuaauaagggaaggaagauuccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccac- acaccaaa uguaucccgugcugagccuccaagucuuucuggagagucccaugacucuaagcaggaugucacguuuucaguuc- ccagcuc aaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgagaccucuguua- uccacucc cuaccuuuuggugaguugcuugcaggucaccguagggcaaaguucuuugagugucaggaaugcggggaggccuu- ugcucg uaggucugagcucauugagcaccagaagauucaugauagagaaagaccuucuggaagccgacauuaugagcgcu- cugucau ccgcagccuugcgcccagugacccucagaccaguuaugcccaagaacguuucauccaagaacaagugcguaaau- ucagagcg uuuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuaaugccga- ggagcccc augauaaagaaacucauggucaaaaaauucaugacaaagagccauaugguaaggagcccaguggcaaggagccc- caugguga ugagccccaggacaaagaaccccuuguucaggagaugcgcagugaagagccccaugaugauaagccccauggcc- aggagccc caugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccacggugaugagcc- ccauggcc aggagccccacggugaugagccccaugacaaggaacccauugaucaggagaugcgcagugaagagccccacagu- gaagaguc ucauggugaugagccccauggugaagagucccauggccaggagaaaguugaagaugcuaccauucaggccucag- uuucuga agagcaucagaaagaugacgcuggugaugcaaucuaugaaugccaggacugugggcugggcuuuacugaucuca- augaccu cacaagccaccaggacacccauagcagaaaggcucugguugacagucgugaauaugcacauucugaaguucaug- cccacucc gucagcgaauuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauuca- cagcucg uuacuuuucgagcaccagagaguucacgaacaagaccagcuguauuccguaaaggccuguuaugacgcuuucau- cgcucug uugcccguuagaccaaggagaaauugcacuguugaaaggaauccugccguuucugggucagccauucgaugccg- ucagug uggacaaggcuucauucacaguucugcccuaaaugagcacaugagacagcacagagauaaugaaauaauggaac- agaguga gcuuucagaugagauuuucauucaaggccuagcccucacugaguaucaggggagugaaacagaagagaagcuuu- ucgagug cacaaucuguggggaaugcuucuucacugccaaacagcucggggaccaccacaccaaaguucacaaggaugagc- ccuaugag uaugggcccuccuacacccaugccuccuuucucaccgagccccucaggaagcacaucccacuguacgaaugcaa- agauugcg gccaguccuuccuagacgacacugucaucgcugagcgcaugguguuucauccugagcgagaaggugggucagaa- auaguag cugccacugcccaagaggucgaagccaauguccucaucccacaagaaguacugcgaauccaggggucaaaugca- gaagcugc ugagcccgaaguggaggcugcagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauug- gagagg cugaagggccagauggagaagcugcugagccugauggcgaggcugagcagcccaauggagaggcugaacagcca- aacggug augcugacgagccagacggagccgggaucgaagacccagaagagagagcugacgagccugaggaagacgucgaa- gagccag agggagaugcagaugagcccgauggugcagacauugaagacccagaagaggaaggagaagaucaagagauugag- guugaag aaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagcucagccuuuggcgagcaucugaaaagu- cacgccag ugugaucaucuucgagccggccaaugcuccuggagagugcucuggcuacauugaacgggccagcaccagugcag- guggug cggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaacucuucaacgaccgccucucccuugcc- agacacca gaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaagccaaaccuucuucccagaaccagac- ccuuaaua aaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccuuccuguauacauaccggacuuca- caucaaaga cuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggacucuuucaguuuuagcuguucccu- auggaac aucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaa- accuagu gacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuuucauacccuauacauaaugauu- ccugccau guauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuauagaauuuacaguuuacucuacag- agcuacc uagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagcauauauuuguaaguauugucca- ugcaga agcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggaguguucuguccccuaccucuuag- auagucc ugugaaggugugggugugaaagaucgugugucuuugaauccuggcuguguggaaacaggcauuuuagcuucuac- agccau uuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggauuugucucugugacccaa- aucaacc caucccuacauuuauauaccuuacagugguuuucuugc Growth Factors, Receptors and Related genes Fz2/ 9 (17) uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga 238 Frizzled 2 guccguagggugcacccuccccccuccugagugaaggagggcacggugc AW123618 aguccggaccugggagaggggaaagcccggcaggcaggcgagaccgcuu cacacaguggucucgccaugccggcuguuggugagacgaguguagaacu uccuccacgagugcagugucuugccggaccagauccagaagcccgacgu gaugcccacgaugagcgucaugagguauuugaucauguagacugugaa gucgggcgacaugcggggcguguagugggccgggcaggggauggcuag gcucuugcagugcuggcuuacccaggagcgcucccagugcucgcggaag gccugcucauagaaguagcaggcgaug Dkk3/ 6 (22) Sequence below. 239 Dickkopf 3 AJ243964 ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcuc- agcuuug uucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugc- uggcgg cggcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaac- uacccuca ggaggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgca- gugccgu ggaggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacu- aucacaa ugagaccagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaaca- accagagu ggacagguggucuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguau- cauuga ugaagacugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagc- agaugcu

augcacccgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaag- guggcaa ugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguucc- ccgugu gcacaccccugcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaa- cuggagcc ugaaggagcuuuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguaca- ugugcaa gccagccuucgugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaag- auguugg cuucauaggggaagugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggc- cugcccc uguggagucacuaggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaa- auggcu aauuuauuuucccaggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuug- acaagg uacagugcaguacauuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcag- cgguga gucgucccucgcuguugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugg- gaagg ggugaagucugcucaugauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaa- aaugua accuuugcuuuugucuugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggcc- ucccaca uauucaucccuguguuucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucacc- acagccua ggaggggaccagaggggacuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagc- gacagccc uuccaaauggagggagugaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucagg- cugacu ugcaugucccucuaacguucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagc- cagugcu cggagugcaguucguguaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaa- uuugca aagucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagagu- acagcug ugacauacagacagaagaaggcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuac- cauucug uaucuauccagaguuauuaaaauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauu- auaugua uacacaaacauguggcccucaaagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuuga- uuuucaa uaaauacaaauccccuucaugcaaaaaaaaaaaaaaa Sfrp 1/ 6 Sequence below. 240 Secreted frizzled- related protein 1 U88566 gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgc- gccagccc cgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccg- acgggcc ccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagc- cccgac gucgccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcgu- uggccg ccgcucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucag- agcgggc gcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaag- aagaugg ugcugcccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcuc- aacaaga acugccacaugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccg- ugucgcu ggcucugcgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcuc- aaaugu gacaaguuccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagg- uacaaccg uguguccuccaugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacug- aggauga aaaucaaagaagugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcugggg- cccaucaa gaagaaggagcugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaacc- ucagcca caacuuucucaucaugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaa- acaaggag uucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacugggg- cggacug gggaaggggaguguggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugc- ucuca cccauacaguuguggcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagcc- acaucca gcuaaggccacggccuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugc- aaaagg agaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaa- aacggauu guaaagaacugcagacggacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucu- aagccuc uacagguagaagagucugaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuu- agauaga ccaucgccaccuucaaaacacacacacacacacacacacacacacacacacacacacacacacacacacacacu- ucugaaaguag ccaggguaucccaguauagaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuu- ugaacu ggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggc- aaggguc ugcuuuugucugaaggagguacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuag- uuuuca acaauagaguggaagaaaugagcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccu- gugccaa cagccucacuuuguaauuccaucugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauac- ccuccaag gcuugaguaaaaguccacacucagcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauaca- ccgccuau gcaugugcuguggaaggcaacucugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccgg- aaucag uauagcguggaaggagacaguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauug- ccuauaa uucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuu- gaggcua aagugcccuauccgaggagaugguuucaaaggcuaacuaaucugcagcuuucccaagugcccagagguauuucu- caaaguu gguaugcuuaauaagugauguaaauauuccaguucucuuaggcagccuuacuccuguugucccug Dab2/ 15 Sequence below. 241 Disabled homolog 2 U18869 aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucggg- cgcggg ggaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcc- cgccgg ggauuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaa- acaagc acaaccaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucuga- aaagacag acgaguacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugug- ccugau gcucgaggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucaggg- acaacac aagcaaagaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaaca- ugaacau ccaguaaauaagauuuccuucauugcucgugaugugacagacaacagagcauuugguuauguguguggagguga- aggcca gcaucaauuuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaag- uuaucua uaauguaaagaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugagg- cccuaaug acccuugaugaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacacc- uccugac cuaaauaguccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacuc- uuuaagag aaaauccauucuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccu- gagaacgc cuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccag- accaaucg gcacccucuucguucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccaca- gaguaaa gggccccugaacgucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccgga- agcucag ggaggcccguggcccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagaga- acagaacg gcuuccauaucaaaucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcgua- aagcagg acuuggaaaguucuguccaguccucagcacaugacuccauagccauuaucccaccuccacaaaguaccaaacca- ggaagagg cagaaggacugcuaagucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccaga- uguccccc acaggacaaccugcagucccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggcc- ccuugua ggucuagguacggucccaguaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaac- ugugguc ccaggagccauaauaaguggccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguaca- agucugg aaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggc- gcccaacg cuuggucauccacaagcccucuggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacu- caguccuc uccucagccuaugauguccucuguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggaca- uucccagu gacgcuuucacuggcuuagacccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuucca- gcugcgg cagccaccucuuguucccucaaggaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuu- caacaau aaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaacaagauuaauga- accacca aagccagccccgagacaagguguccucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaa- aggguuc agcucaucaaaccccucugugguuucucagccugcaucuucugauccccacaggagcccuuucggaaauccuuu- ugccuag cuucugaaguuguaaugaugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccag- aaacaug uugaccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaa- augccu uucauuuuccugucuaggcuaaagcuaaacuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagc- uccaaua uaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuugaaacuuccagaauauucuccauucua- cccucca uuugggaggagcggcuaccuuuacccuuaauaucacacugccuugagucaauguccaaauacucauagcucuca- aagucau uugggguuccuggugugcggccuaaaccuaaagcauccuauuaauagggaaguaagacaccuugcuuccuaugu- ccacuca gggagaauuuuauuuaauaaaaugaaagcaagacuaacuucucaaauccacccaaggaccauuuugagaugguc- guuucuc agcuaacugcaccauuuaccaauccugccccaaguggugcuuacauuugacuugaagaagagaaagagcuaacu- caaaacac aaggcauuauucaaagcuaauaaaacaauuucucccuggggccccacauuguuuucauuccagauacguugcag- cuguuug acccugaugacauuaugcccuacauuuuccuugaagauccugauuuuauuucaugugauuuuuguuucucaaua- aagaug auuauugugugcacggaauuc Cktsf1b1/ 12 (12) Augaaucgcaccgcauacacugugggagcguugcuucuccuccugggg 242 Gremlin, acccuacugccaacagcugaggggaaaaagaaagguucccaaggagccau Cysteine uccgccuccugacaaggcucagcacaaugacucugagcagacccaguccc knot caccacaaccuggcuccaggacccgggggcggggccaggggcggggcac superfamily cgccaugccuggagaggaggugcuugaguccagccaagaggcccugcac 1, BMP gugacagagcgcaaguaucugaagcgagauuggugcaaaacucagcccc antagonist 1 ugaagcagaccauccacgaggagggcugcaacagccgcacuaucaucaac AF045801 cgcuucuguuauggccagugcaacuccuucuacauccccaggcacaucc gaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaa guucaccaccaugauggucacacucaacuguccugagcuacagccaccca ccaagaagaaaagggucacacgcgugaagcagugccguugcauauccau cgacuuggauuaa Fgfr1/ 10 Sequence below. 243 Fibroblast growth factor receptor 1 U22324 guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagug- ccuccu cuucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagc- ccugggg agucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaug- augugc agagcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggaggug- gaggug cgggacuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccua- cuucuccg ucaaugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagag- acggacaa caccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcgg- ugcccgcu gccaagacggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaa- agaguuu aagccugaccaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugcc- uucugac aagggcaacuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucgugga- acgaucu ccgcaccgacccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucau- guguaag guguacagcgauccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccaga- caacuug ccguauguccagauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaa-

ugucucc uuugaggaugcgggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugac- cguucu ggaagcccuggaagagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccgggg- ccuuccu gaucuccugcauguugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagcc- agauggc ugugcacaagcuggccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccauga- acucugg gguucuccugguucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagc- ucccuga ggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcagg- uggugu uggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaagucc- gacgcaa cggagaaggaccugucggaucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucauc- aaccuuc ugggagcgugcacacaggaugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguau- cuacagg cccggaggccuccugggcuggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagau- cugguauc cugugccuaucagguggcucggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcua- ggaacg uccuggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuac- uacaaga aaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccag- agcgaug uguggucuuuuggagugcucuugugggagaucuucacucuggguggcuccccauaccccggugugccuguggag- gaacu uuucaagcugcugaaggagggucaucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugc- gggacug cuggcaugcagugcccucucagagaccuacguucaagcaguugguggaagaccuggaccgcauuguggccuuga- ccuccag ccaggaguaucuggaccuguccauaccgcuggaccaguacucacccagcuuucccgacacacggagcuccaccu- gcuccuca ggggaggacucugucuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuugc- caacagu ggacucaaacggcgcuga Fgf1/ 10 auggcugaaggggagaucacaaccuucgcagcccugaccgagagguuca 244 Fibroblast accugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaac growth gggggccacuucuugaggauccuuccugauggcaccguggaugggaca factor 1 agggacaggagcgaccagcacauucagcugcagcucagugcggaaagug M30641 cgggcgaaguguauauaaaggguacggagaccggccaguacuuggccau ggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugu cuguuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaa gaagcaugcggagaagaacugguuugugggccucaagaagaacgggagc uguaagcgcgguccucggacucacuauggccagaaagccaucuuguuuc ugccccucccggugucuucugacuag Gpr49/ 64 Sequence below. 245 G protein- (377) coupled receptor 49 FEX AF110818 auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucacc- gggacca gaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacug- cucgga ccuggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacauca- gucagcua cccgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucc- caaggga gcguucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagc- gcuacag aauuugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcgg- ccugcacu cccugaggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcc- cugcaag ccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguu- cugcaucu ccauaauaauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaa- auuauaa uaaccuugaugaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaaca- ucagguca auaccggagcgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuugu- uggagua ucugcuuuucagcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccuca- cuugaca ggaacugccacccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugauca- guuaccu aaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuuca- gaaaauu gaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaa- cuuagca uggaauaaaauugcuaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauc- caaucuc cugucguccuucccugugacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagag- ccugaua ccaucugcaaacuucccagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggug- ugagaau gucuauaaaauuucuaaccaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcugg- guuauuu caaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggu- gcagugc ucgccuuccccaggucccuucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggac- cacggca guacugacgcuuuccugcaaugccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaa- gcugcua auugggguaaucgcgguaguggacauucucaugggggucuccagugcugugcuggcugccguggaugcauucac- uuuug gccguuuugcucagcacggugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuu- gcuucc gaaucgucgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuuga- agugaa agcuccccuuuuuagccugagagcgaucguuuugcuauguguccuguuggcccugaccauugccacaauccccu- ugcuag gaggcaguaaguacaaugccucuccccucugccugcccuugcccuuuggggagcccagcaccacgggcuacaug- guggcuc ucguguugcucaacucucucuguuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaa- ggagagc uggagaaucuuugggauuguucgauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugc- cccgug gcuuucuuauccuucuccucuuugcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgu- gaucguc ccacuuccuuccugucucaacccacuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccu- gggaaag cauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgauguugagaaacgguc- cugugag ucaacccaagccuuaguauccuuuacccacgccagcauagccuaugacuugccuuccacuuccggggcaucacc- agcuuacc ccaugacugaaagcugucaucucucuucaguugcauuugucccaugucucuagugacuaugagagaggaacguu- uuuaag aguuggaaaccugaaaagugauuucuaucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaac- ccaagcaa acaucucuaaauugguguggaaacaguggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuu- guucagc uaagaaggaaagccaucaagucacuuaggugaacccagaugagaaaagcagccugaaaugcucuucgcauugua- gucucuu cugacucaccagcauagucucccauagugagaagacucguuggaugacucaauggguguauuuaaauccacaaa- uuccuug uuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa Igfbp5/ 37 Sequence below. 246 insulin-like growth factor binding protein 5 L12447 uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucu- gugguu cucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugca- ccuggcgc gccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaa- uccuccu ugccucauauuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuc- caggcuc ccucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucag- cguggucc uccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgag- aaagcuc uguccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugc- gcccug gcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggauga- ggagaa gccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauag- agagagac ucucgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaa- gcacacuc gcauuuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuugugggg- ggugca gagaacacugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcag- acacaugg aagcuucccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgc- aaaggau ucuacaagagaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacgga- augaagc ugccgggcauggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguc- cccuccc uuccucccccuauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacucauuu- caucucauu uaggggaaauauauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagaca- cucccca ccaugaccccggaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaaga- gggagcg agagauggaaagaaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagaga- gaaacag caaggcagaaaggacuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaa- guguggc auucagugacacccaguuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguc- cccuccu gcagccagcaguguggauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucaucccc- aaauuua caaagacuaaaaugcauuccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagca- gacaagug aacucagaaugugugcaaauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacugga- aagacuu gauucuccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggccc- ggcagcc ucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuau- aggcaua uaaaucuauuuucuuuaccuuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuu- uuuuua ggacacugaagaucuuccucauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccu- gcguccag gcagccuuucucgugagcuacaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacg- uguguu gaagugaauccaccaagccagguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauu- ucagccuu ccaacccgcagaaaguaacugucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccug- cccagaccu uuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucag- agagaaa cuaacaugagagaugacagaggaggaggaaguggagggugggggcagagacuuccacagagagacauagaagau- ggagcag aggucuggggguggggaggacaagaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucuccc- aucuaau caacucucugagauuugagaggaaaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaaguca- cagggcc cagaugguggguaacugaggcaggauccagacuugagacacacgguuggaaacaaggcugguuagccugacugg- guauug aagggugaagaggaugccuuggaaagacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggc- caaagaau ccuucaagugcuucaugagucuccucugcccgacucaaacauccuucccugugauggaggaugguagaaagccc- aggacaa cucaggcccggaucuucacgacuguugucauuugccagccugauuuugauccaagagaagcaucucauugccca- cuggcuu cuucaacaaagaggugcuuaacaaaaggcucaggacuaucuuugaagacugaagauaaccuuccaggagaggag- acucgga cauugguacaggaggccccuuuuggcgggggacacagcucuuugcgcucucuugauggcauggcauaguagagg- cccccu ccaacccggaacauggagcaacacaaagggagagcaaagaaacugacgugcgucgacucauaggacaugggugg- cugcggg cacagaaagggaugccuccuguugccuggacaggacaguuggcugggaaggaaagagaaaauugaucuucauaa- gacaaag ggccugaugggauggcaauagaaggacuuaccagaccugcagggucaguauacccaucaccccgcacaacaucc- ccagcccc caacucaaacuucaauauaucuuaggccaguauccuagaccuaagucucuccuuucugccauuauuucuccgca- ucuugag cagucaucugacugagauuugccaaguggauacugggguaccacugccccccaagaaaagacugagccaggaac- ugccuac ucgcucccccucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuug- agugagc cucugucccuuaugugggcucuucgcugugagccacagauggaggucauuguauagacaguuagccuuccccag- gucagc cuaccucccccaaacuugugagucuccccgcugcucauauggagaggcaugucuaagacagcaagucuucuaga- ggaagcu ugccuuuaacagacagauggaacuaaaccuuccaaaugggagaucuggcugaacccaggauacagagaccaugg- acaugga uggggucaucaagagaagagggauguccuucuccagguuagggagagagaaggcaaguuugcaacgaucccauc- augcccu gagcaagaagcuuuuggcccaggcuagccuuuaacuccauuagaggccucucuguuggguuuauccacagcagu- aggccca aguauggccuguccccaccucuacuaucccguggaagguuucuucccaccccuuuuugacaaaugccucacucg- agcagug gaaagauagcucucuucccccucuucugccagguaacaaagagaccuaaccaggaccuauucuccaccccagcc- agucuuga

ccagccagaacaaagcagggaaccuggagaauaaaagacucuacguuccucugacaaagacucuacguuucucu- gacggcca ggccuaaacagacaaggcuugggaacaucugccccacaggauacggaggaggucagcugugcucacuccucuuc- uccuucc aagacccucuuccgaccaugacuuaucuccaugguaacauccucaccaucauucucccacuaccaaggguugcc- auggcaac cucccaaccaccugcccaucccaggcaggcagcuguccuucugcucagaacccuagaggacucuaggugaaauu- uuacagcu uaagagaggagugagccaaggagaagagacccuguaguccucuggcuuucaagagaaagaaggcuaugauuuaa- aacacag uagaagggaaagaggucucgucgaggucgaccucucccggggagcuuagggguuguacugucuuuauuuuuuaa- accacu aaagugcaaunuuuccugcacucuuguuaccccgccucucuucccuguuagguuuucauuuccuugagcagacu- uucuug guuuuuuaauggaguauagacuuucaccacuucacagacucuggccuccucuccaagucucucuggauggggaa- aaggaag guagagggucagaggggaaggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucac- cggcuuc accccnaucuccgacaccaucacugucacacaguagccugucacacggauaguacaguucagacaagacuccuu- cagauucc gagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuacaacag- caau aaccacaucacauauuacuguagcucucuauaguguuacguucagacaccguagcucuguccucucuuauuuug- uugguu uugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaaaaaauugaacaacaaaccaguu- ugugaaaa aaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucuuuagcauuuuguacuuaagga- aauaaaaa agaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa Myoc/ 111 Sequence below. 247 trabecular meshwork induced gluco- corticoid protein AF041335 guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaau- ucauca ggauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguaugg- agugug gaugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagaga- uccgccag guguuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacu- ggagagc acgggugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcu- agacac ggagaccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcu- acacaga cauugacuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauagucc- ucuccaa auugaacccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccu- uuguuau cuguggcaucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaa- cggggacc aguaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagag- gaagcugu uugccugggacaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuacc- agcaaag gccagaaaaggugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucu- ccuccug cuaaagauuuuguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauag- ucgcaua gacucuguucucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug Itm2a/E25 30 Sequence below. 248 putative Integral membrane protein 2A L38971 gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgcgau- ccucucc ucuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaa- gaucgccu ucaacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccga- gcucaaa uccugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuc- cuaggcc ucucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauu- uaccaug gugagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugug- acugag gaggcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgaucc- ggcggc aauuauucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucugaugcccc- ucaauac uuccauuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucaua- cuuaug ugguucgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuu- ugcaac aaccgaaaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcug- gaagauu agacacuuccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguaucc- uugauaa uaagaagucaggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacau- uuacucu auugcuuauacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucua- cuuuaau ugacauugcuugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaa- agcagc augaaugugucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaaca- ucacuug gcuagagcaugcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucu- cuuacc auucuuugguuuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggu- gcugu guaacgaaucugacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucuca- cugauau cuguauugugaaauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaac- ccuauaa uaaaguuuaccguauucaauca Eps8/ 15 Sequence below. 249 epidermal growth factor receptor pathway substrate 8 L21671 ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgc- agggcgc ggggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucgguc- accuccc ucgcgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgug- agagcc ggcaugaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggauc- uucacca cccuauucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacua- ugcccgag acagugucagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaa- gaugcaa ugaucacugucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaug- auucucc aaguggaugaccgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacaca- aucucgc auugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagc- aagccag accuucaccuuuuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugac- aguaaag gugggaaacagaagaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccuccc- agagcuc cugccccugugccaccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggca- gcugacc agggugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgac- agggaug ugcaaaucuuaaaccauauuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuu- ucugagc uuucuaaaaggaagaaaaguaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaa- ccgccacc uccugacgaguuuguugacuguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccaua- uccagaa cccgagugcuucagaucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccug- aacugg ccaguucgguacucagcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaa- cggaagcu guggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacg- ucccgag guuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacugg- ccgaguc cguggccaacgcagaacaccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacu- auccucca gccgacggauaugcguacaguagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugcc- uuucaag ucaacuccuaaucaccaaguagauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaa- guacgacuu uguggcgaggaacagcagcgagcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcagu- ggugga aaguccggaaugccaguggagacucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucu- ggagugg ggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauacggccugagaucagcugacacu- ccuucugc cccaucacccccuccaacgccagcacccguuccggucccccuuccaccuucuguaccagcacccguuucugugc- ccaagguu ccagcagaugucacccgccagaacagcagcuccagugacagugggggcagcauugugcgggacagccagagaua- caaacaac ucccaguggaccgaaggaagucccagauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgc- agugcug cgcagaggaaguuccacgugccacggcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaa- guaaagac uuggcugcagucaaagggauucaaucccgugacugucaauagccucgggguguugaacggagcacaacucuuuu- cucucaa caaagacgaacugaggucugucugcccggaaggugccagagucuuuaaccaaaucacuguucagaaagcugcuu- uggagga caguaauggaagcuccgaguuacaagagaucaugcggagacggcaggagaagaucagcgccgcugcgagcgacu- cgggagu ggagucuuuugaugaagggagcagccacugaguccaugaacuuccuuauucuugguguggucguugaacaguga- uggaca ugcuuuguuuuaagaagccuugaagggaaugucaaagcugucgucuugguauauguaauuuaucgccauauaag- gaaaca guauaugccugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguagg- ugagau ggcucagcaaguaaaggugcuugcugccaagcccaaugacccaaguucgagucccugggucuacaugguaggag- agagcug gcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuuacaaacuuuuaaaagaaaa- uguaauuu aaaaaaccagacguucuagacuguucugggcuugggaaauauuuuuuucacuuuccuaagguguacuuuccuuu- gcuaca uuaauuauugcagccuuguucgaugaucuaaguggggauauuugacaauggcagauuuauucauugcaacaagg- aaagac acagccauugaugaaaaaaaaaagaaagucucagcuuucagugacugggauaccugcuguccagggaggaggcu- caguuag acuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaaugcc- aacaguu uuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguaugaauagacuauauaauaugucc- cgagaaac uuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuugauuuaguuucu Fyn/Fyn 10 Sequence below. 250 proto- oncogene M27266 ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaug- ugcucc ggagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccg- accgcug guuucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugug- ugcaa uguaaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcua- uggcaca gaccccaccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugg- gggccagg gacucaccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagug- acacugu uuguggcgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaaua- uugaaca gcucggaaggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacgug- gcuccag uugacuccauccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccugucc- uuuggaa acccaagagguaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugg- gaugaua ugaaaggggaccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcc- caguuug aaacacuucagcaacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuuca- ucaaguu guaccccacaaacuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaag- cugggg cagggguguuucgcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagcc- aggcacc augucuccggaguccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucua- cgcgguc gugucugaggagcccauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagaugg- ugaagg aagagcucugaaguugccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgca-

ugaauua uauccacagagaucugcgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggau- uggcuc gguugauugaagacaaugaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcg- gcccugu auggaagguucacaaucaagucugacguauggucuuuuggaaucuuacucacagagcuggucaccaaaggaaga- gugccau acccaggcaugaacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugc- ccgaucu cccugcacgagcucaugauccacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggc- uuccugg aggacuacuuuacggccacagagccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccu- cuucccga ggccucccuaccccuccccauuagcuuccaauucuguagccagcugccccagagcaggagaaccguccaggauc- agauugca ugugacucuugaagcugaacuuccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaa- ccaucug agacagaagcguguuauuucucagacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguuc- aguguaa auagcugcuccugugccaacaaucccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuua- acucuga uuucaccugauucaacuaaaaaaaaaaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauu- uuuuuuc auguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa Structurally-related Col6a1/ 36 Sequence below. 251 Procol- lagen, type VI, alpha 1 X66405 cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuuccc- agcgccca cccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugc- cccugcu gcuacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccugugg- aucuauu cuucgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaagu- ccuuca cuaagcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcg- cugcacu acagugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcgug- gaugcgg ucaaguacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggc- ucccacc ugaaggagaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggu- cuggaag augcaguaaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagcca- cgucuaa guaucauugccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaa- gagguca ucagccagaccauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugc- caggcug ccagaggaccuccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagag- aagggag aagcuggagacccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagc- cgugga gagaaggguuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcau- gaaggga gagacgggguacccaggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucc- caagggu gaugcuggugccuuugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaa- cucagg gucaccuggagaugagggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaa- augcug gcccagacggugccccuggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagagga- ccaagg ggagacccgggugaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucggg- ugaggcu ggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagccccagg- accuguu gguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuu- ccccggc uucccuggguauccaggcaacagaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaaggggga- ugagggu gaagugggagacccaggagaggauaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgagg- cccagaa ggaccccagggaccuccaggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaa- aaugugc uccugcugugagugcacauguggacccauugacauccucuucgugcuggacagcucggagagcauuggccuaca- gaacuuu gagauugccaaggacuucaucaucaaggucauugaccgguugagcaaggaugagcuggucaaauuugagccagg- gcagucu cacgcgggcgugguacaguacagccacaaccagaugcaagagcacguggacaugcggagccccaacguccgcaa- cgcccagg acuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugcaguacacc- cgggacc ggcuacucccacccacacagaacaaccgaauugcccuggucauuacggauggacguucugacacucaacgggac- acgacacc ucucagugugcucuguggugcagacauucagguaguuucugugggaaucaaggauguguuuggcuuuguggcgg- gcucc gaccagcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacua- ugcagag cuucucgaugacggcuuucugaagaacauaacagcccagaucuguauagauaagaaguguccggauuauaccug- uccaauc acauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucggcagccacaacuucgaaac- caccaagg ucuucgccaagcgccuagcugagcgauuccugucagcaggcagggcggauccuucccaggaugugcggguggcc- guggua caguauaguggccaggggcagcaacagccaggucgggcggcucuucaguucuuacagaauuacacagugcuggc- cagcucu guggacagcauggauuucaucaacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccg- ggaagcc ucgucaggugccaccaagaagagagugcuguuguuuucagacggcaacucucagggggccacagcagaggccau- ugagaag gcugugcaggaggcccagcgugcaggcauugagaucuuuguggugguggugggaccccaggugaacgagcccca- cauccg ugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuauuccguguaccaaacu- accaggc ccugcuacguggcguacucuaccagacagucuccaggaagguggcacugggcuagagggccacacacguggcug- gacacac auggcauggagacacauuucaacaggccuucccgcccuucccacugacaaaacaggaauaggaaaugugaccca- acugguca acucaacugucuuaaagggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcucaccugag- cuccuau cuagaucccgcccuugguuuguacaucaugguggccaucuugcugaccccucccccaucugggacuggauccag- ccaucuc gucuuccuccucacugccccuaaccuauccguggugucuucacaccaucacugcaguuuccgucuguguucugu- cuuccau gcucaacaugaagcagaccuucucaugaguucagcuugcuggauuauggcuuuuaggaaauugaacacaggagg- aguucca aacacaaacuuggaggagaccccuccucuucaucaggugcuugucagugaccuacaugcaucuuggucuggucc- uuagugg cuaguccuuccacucugaaagcaaaggugcuaucuaucuguaagggcucucucuacacacccagaggcuuagcu- uggacag uucacacucaaguguccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguc- cccaaagg cuccccuuuaguuaguuucuucauggcucccccacauuccccguaaucugauccaagccagcuaucucugcuaa- uaaaggu uuccauuuuucaaaaaaaaaaaaaa Tnc/ 17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug 252 Tenascin C aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc AV230686 acauaaucauggucauggugaugauggaaacugaggacuuuaaaagaga X56304 uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuu guuuuguuuuguuuuuuaauaaaagcacaguacuuuucc Krt2-6a/ 10 Sequence below. 253 Keratin complex 2, basic, gene 6a (keratin 6a) K02108 gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaa- gucaaacc agccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgu- gugccgc ucccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggg- gagcuc caagaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucg- gcauug gugguggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuuc- ccgg ugugcccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugac- cccaccau ccagcgggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaagg- ugcgguu cauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggc- agaacaug gagcccauguuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcau- gaacuca gagcugaggaacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacaga- cgcagaga augaauucgugacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagac- agucuaa cagaugauaucaacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacaca- ucugugg uccucuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugagguc- auagcuc agagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacau- ggggacg accugcgcaacaccaagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccac- guuaagaa gcagugugccaaccugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggg- gcaagc uggaagggcuggaggaugcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacuc- augaaug ucaagcuggcccuugauguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggu- gaaggu guuggaccagucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcag- cagcuu aggcauggguggaggcagcagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcagug- gcagag ccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagc- aagaagag cuacaggcagugaauucugucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugc- uuugguu cccggaagggaacgaaucccaaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccu- auacaug uucuuuggugacccagaccccaaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaa- uacccaccu aaauucugucaugguucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac Channel-related Potassium 14 uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc 254 channel, caguucacaguuuauacgugguacaucccaccaugucagcuuccaga subfamily acggcuauucaggagauggguggagcuuucuuuguaaaggaacccga K, member cauuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacuc 2 ucugcaagcgaacuggauauauuuacauuuauagcuuaaauucaaau AI849601 uuuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuua ugucuuaagacuuuacucugaaugccacaugaucacguaagcccaag ccucccccagaagggaaaaaucaguuuugc Skd3/ 4 uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua 255 Suppressor uuagauguucagggcacagacagguggaugcuagaugguguagcaca of K+ ccuucucaggguggaguggugccuggauguccaguuugcgggucuu transport gcuguccuuaucaaugaucuccagucgcaauguagguggacgcuucu defect 3 cagccuggggugagggcagcucacggcucuugaggaggugcuuguc AI837887 cgaauccuccacagugauacccagggugcaacccccugg Clic4/ 3 uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuu 256 Chloride acacaauauuacaacucccccaguacauaaauguuccuauaccaugca intracellular cacagcaacaugggguccacugaugucgcaggcgacuuuucuaaugg channel 4 uggaacauagcaccucaaguucugccaucuacacagugaagggacgu (mito- gauggucggggcuccagagugacagcaaacugccucuugggugacac chondrial) gcuuguggcgaagugccucc AI845237 Col18a1/ 5 Sequence below. 257 Endostatin (alpha 1(XVIII) collagen) L22545 gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucga- ugacccu cacgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacu- cuucuuc cgggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugc- ugcccag gugguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacgga- gccuggg gccagccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucag- cgucgac ggaggcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacu- ggagcu agagcguggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucag- agcuga agguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucu- ggagauu uuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagcca- ccuccug ucacuuccccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcg- guagauuc uauaggagcugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggg- gcuugau aaagggagguaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguc-

cugccgg uccagugguccagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccag- ggaaggau ggcacuccaggaagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaagg- cuuucca gggaccccaggagaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggcc- uccaggg ccaccaggacccuccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacau- agagagcc uuagaggcccacgaggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgc- uuuggga ucaaugguuccuaugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuucca- ggucccc cgggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugug- ggcaucc caggacccaaggggagcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccu- gggccag uuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaa- ggcucug gaauaccccucuggacaacagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggg- gauccug gaguggcaggccuaccuggagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccagga- agagaag gugcagcuggaucuccggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagaugga- gugggcc ggccgggccucccugggccuccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagug- agcacgc caggaccugagggcaagccaggguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaa- ggcgagc agggucuuccgggguuuaagggugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggc- cauccc cagaagggagccaagggagagccaggcuuucgaggacccccggguccuuauggacgaccugggcacaaggguga- aauuggc uucccuggacggccgggucgaccuggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccu- uggguu cagcaugaggggauugccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuaugaca- gcaaugc auuuguggagucuggccgaccuggacuaccaggacagcagggugugcaggggccuucaggaccaaagggugaca- aaggaga gguggggccaccugggccaccagggcaauuccccauugaccucuuccaccuggaagcggaaaugaagggggaca- agggaga ccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauucuucagcucaagug- uaccug gcccacccggcccaccuggauacccuggaauuccggguccaaagggagagagcauccgggggccaccuggcccu- ccuggccc gcagggaccuccuggcauuggcuaugagggucgccagggucccccaggaccuccaggaccuccaggaccucccu- ccuuccc uggcccucacagacagacugucaguguuccugguccuccgggcccaccugguccuccaggucccccaggagcca- ugggugc cucugcugggcaggugaggaucugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcu- ggcuca ucuuuguggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcuggaggcccgg- acagcc cuccugagaggcacgggcaaugagguggcugcuuuccagcccccauugguccagcuucaugagggcaguccaua- cacccgg agggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaacccaccgcgccugccaga- ccgccagc cuuacccuggaguuccacaucaccacaguuccuaugugcaccugccgccagcccgccccacccucucacuugcu- cauacuca ucaggacuuucagccagugcuccaccugguggcacugaacaccccccugucuggaggcaugcgugguauccgug- gagcaga uuuccagugcuuccagcaagcccgagccguggggcugucgggcaccuuccgggcuuuccuguccucuaggcugc- aggauc ucuauagcaucgugcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucuccc- agcugg gacucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacggcagagaugu- ccugag acacccagccuggccgcagaagagcguauggcacggcucggaccccagugggcggaggcugauggagaguuacu- gugagac auggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugucaggcaggcuccuggaacagaaag- cugcgag cugccacaacagcuacaucguccugugcauugagaauagcuucaugaccucuuucuccaaauaggccucugcca- gcuaggg uggcagacagaggccaugcagaacuuugacacagcgcagggagcauucagucagcacccagggcucuggcuggg- auacaac uccuguauaguucccauuuuuauguaauccucaagaaauaaaaggaagccaaagaguaaaaaaaaa

TABLE-US-00006 TABLE 5 Genes down-regulated in HF stem cells. Gene Fold SEQ Name/protein Decr Sequence ID No. Growth Factors, Receptors and Downstream genes GNA- 14 32 Sequence below. 258 Mouse G protein alpha subunit (GNA- 14) M80631 aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccu- cuucaaa ccuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagc- cauggcc ggcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccg- cgacaa gaaggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagc- agaugag gauaauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauuca- cggccau gcaagccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccaga- ucaucagg gaaguggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucc- cggaauc caggaguguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcg- uaucgcc augcccucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauaucc- auucgac cuggaaaacaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuu- ugagag ugucaccuccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaacc- gcaugg aggagagcaaagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuua- aacaaga aggaucuucuagaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaa- gaugucaa agcggccagggacuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacu- ucacuug ugcuacagacaccgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacggg- aguucaa cuugguguaaauggagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugc- uucugg accaggaccuaaggacauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacc- cuuuuaag ugucuuuaauucuucacugucuaacucuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguu- cccccu cuccuauuuuuuuaaacuaguguucaacaguuauuaaaaaaucaugc Ly6/Lympho- 12 gaauucccugcaaccuugucugagaggaagcaaggacuggugugag 259 cyte antigen 6 gagggagcugugagguuuuaucugugcagcccuucucugaggaug complex gacacuucucacacuacaaaguccuguuugcugauucuucuugugg X04653 cccuacugugugcagaaagagcucagggacuggaguguuaccagug cuauggagucccauuugagacuucuugcccaucaauuaccugccccu acccugauggagucuguguuacucaggaggcagcaguuauuguggg uucucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcc cuccuaauauugaaaguauggagauccuggguacuaaggucaaugu gaagacuuccuguugccaggaagaccucugcaaugcagcaguuccca auggaggcagcaccuggaccauggcaggggugcuucuguucagccu gagcucaguccuccugcagaccuugcucugaugguccucccaaugac cuccacccuuguccuuuuauccucaugugcaacaauucuuccugga gcccucuagugaugaauuaugaguuauagaagcuccaaggugggag uagugugugaaauaccauguuuugccuuuauagcccugcuggguag guaggugcucuaauccucucuagggcuuucaagucuguacuuccua gaaugucauuuuguuguggauugcugcucaugacccuggaggcaca cagccagcacagugaagaggcagaauuccaagguauuaugcuaucac cauccacacauaaguaucugggguccugcaauguucccacauguauc cugaaugucccccuguugaguccaauaaacccuuuguucuccc Bmp4/Bone 11 Sequence below. 260 morphogenetic protein 4 L47480 ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugggaaggcaag- agcgcg aggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaac- ccagccu gaguaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggc- ccucgac cagguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggug- agcaggg caaccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcug- uaaccg aggcaaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcacc- uccauau auguuacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcgggaaggagagaaggccuuggaa- gagagg ucauugggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaa- cucuaa guuucaacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaag- aggcugu aguccugcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccc- caacgca cccccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuua- gacauggg cacccaugauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggcca- ggaugcc gaaaggcuaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuug- cgauac uccaaaggguucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgcc- acggcu uugguugauaguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcaggguc- auauu uggcaaaccgaggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuc- caggag cuguaucaaccccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaa- aaaaaauc agggaagaaaggagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgcca- gucgcua gcauaucgccaucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcu- uucccagu uauucccagcggcgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcgg- acuguc gcucaggggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccagga- aggacgu gacucuccauccuuuacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggug- cgggggg ggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcggg- cucugg agcgggggaguccugggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguugcgcuucc- gagguu agaacaggccaggcaucuuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuu- cuuggag gaaucuuagccgcgauucuguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcgggggu- ggcgg uggggguggaggugguuuaaaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucgg- guuugu agacgcuugggaucgcgcuuggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagauc- guaaaa aaaaugugaugcgcucuuucuuuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccacc- ccccacc ccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgc- ugagguu ggcagacacgguguggggacucuggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccac- accgcuc aaaccccgacacccccgcggcggacugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcua- ggggucg gcugccugucgcuagaagcauuauuuggccucucggagacccguguggaggaagugcuggagugugcgagugug- uuugc gugugugugugugugugugugugugugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcu- uucc uuuucauggaacgcugucgugaggcuuugguaaacugucuuuucgguuccucucucggcugcacuuaagcuuug- ucggcg cuguaaagagacgcgucuucaagugcacccugauccucaggcuucagauaacccguccccgaaccuggccagau- gcauugca cugcgcgccgcagguagagacgugccccacguccccugcgugcagcgacuacgaccgagagccgcgccagugug- guguccc gccgagaguuccucagagcaggcggggacaacucccagacggcuggggcuccagcugcgggcgcggagguuggc- cucgcuc gcaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcucuucggugaguggggcggggcc- ucugg guccacgugacuccuaggggcuggaagaaaaacagagccugucugcuccagagucucauuauaucaaauaucau- uuuagga gccauuccguagugccauucggagcgacgcacugccgcagcuucucugagccuuuccagcaaguuuguucaaga- uuggcuc ccaagaaucauggacuguuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuucuugggau- uucacu cuguccucccaucccugaccacugucugucccucccgucggacuuccauuucagugccccgcgcccuacucuca- ggcagcgc uaugguucucuuucuggucccugcaaggccagacacucgaaauguacgggcuccuuuuaaagcgcucccacugu- uuucucu gauccgcugcguugcaagaaagagggagcgcgagggaccaaauagaugaaagguccucagguuggggcuguccc- uugaag ggcuaaccacucccuuaccagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaaaa- aaaaaaaa acaaaaaacaaacagucguuugggaacaagacucuuuagugagcauuuucaacgcagcgaccacaaugaaauaa- aucacaaa gucacuggggcagccccuugacuccuuuucccagucacuggaccuugcugcccgguccaagcccugccggcaca- gcucugu ucuccccuccuccuguucuuaaccagcuggaaguuguggaaauugggcuggagggcggaggaagggcgggggug- ggggg guggagaaggugggggggggggaggcugaagguccgaagugaagagcgauggcauuuuaauucucccuccnccu- cccccc uuuaccuccucaauguuaacuguuuauccuugaagaagccacgcugagaucauggcucagauagccguugggac- aggaugg aggcuaucunauuugggguuauuugaguguaaacaaguuagaccaaguaauuacagggcgauucuuacuuucgg- gccgug cauggcugcagcugguguguguguguguagggugugagggagaaaacacaaacuugaucuuucggaccuguuuu- acaucu ugaccgucgguugcuaccccuauaugcauaugcagagacaucucuauuucucgcuauugaucgguguuuauuua- uucuuu aaccuuccaccccaacccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuau- gccaaguc cugcuaggaggcgcgagccaugcuaguuugauaccugagaccgggaagaaaaaagucgccgagauucagggcca- cgcggga ggacgccgcucagggcagagccaugagcuccugcgggacuucgaggcgacacuucuacagauguuugggcugcg- ccgccgu ccgcagccuagcaagagcgccgucauuccggauuacaugagggaucuuuaccggcuccagucuggggaggagga- ggaggaa gagcagagccagggaaccgggcuugaguacccggagcgucccgccagccgagccaacacugugaggaguuucca- ucacgaa ggucaguuucugcucuuaguccuggcgguguagggugggguagagcrccggggcagaggguggggggugggcag- cuggc agggcaagcugaagggguuguggaagcccccggggaagaagaguucauguuacaucaaagcuccgaguccugga- gacugu ggaacagggccucuuaccuucaacuuuccagagcugccucugaggguacuuucuggagaccaaguagugguggu- gauggg ggaggggguuacuuugggagaagcggacugacaccacucagacuncugcuaccncccagnggguguucuuuagc- uauacc aaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaauauuacancuguguguuugucaggu- uuauca auaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuccaaaguaaaucugaguuauuaau- ccucca gcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaaggcgugcucuguguuucuaggau- cgcugg ggaaauguuugguaacauacucaaaaguggagagggagagaggguggccccucuuuuucuuuacaaccacuugu- aaagaaa acuguacacaaagccaagagggggcuuuaaaaggggaguccaagggugguggaguaaaagaguugacacaugga- aauuauu aggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugugagcuaaguuuugcugguuu- gcuag cugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagguuucuacuauauaagca- gaauucaa ccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuuuuuuuuuuuuuuuuuuuuug- ucu cagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucuggagaacaucccagggacca- gugagag cucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucuccucggcagagcuccggc- ucuuucg ggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugagguuaugaagcccc- cagcaga aaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugugacacggugggaaa- cuuucgau gugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauugaggugacucaccu- ccaccag acacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggagauugggcccaacu- ccgccccc uccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacguagucccaagcau- cacccac agcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgugggcuggaau- gauugga uuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcugaucaccucaac- ucaaccaa ccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguccccacugaac- ugagugc cauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggugguagaggggu- gugga ugccgcugagaucagacaguccggagggcggacacacacacacacacacacacacacacacacacacacacaca- cacguuccc auucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaaaagaa- agaaagaaa gaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuuauga- cuuuacgug caaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaaaugag

IL1r2/Inter- 11 gaaucccacuuacaugcgagcaucucuauauacauccucaaucuauc 261 leukin 1 cccucgaauccacggacuuaucagucaaucaauacuacagucaaaga receptor, type auuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuu II cuaaucaucuugguuguggggccaauauggaugcgcagacggugua AV223216 aacgcagggcuggaaagacauauggacugaccaagcuacggacugac X59769 aaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa Wnt3a/wing- 4 Sequence below. 262 less-related MMTV integration site 3A X56842 gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagc- ccaggcg uccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagug- cucugca gccugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagc- acucagc ccauucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaug- cccagcg uggcugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccacc- gucagca acagccuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccucc- gcuggag uagcuuucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggc- uccccag gcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgau- gccag ggagaaccggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccaguc- acaugcac cucaagugcaaaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccg- caccauc ggggauuuccucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcug- ggugga gacccugaggccacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucaccca- acuucugc gaaccuaaccccgaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugg- gugcgac cuguugugcugcgggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauug- gugcug cuacgucagcugccaggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacggga- gcagggu ucauuccgaggggcaagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucggu- ucuuac uugagggcggagauccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuau- uuggga ucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggg- gaugg aauuccaauuugggccggaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggag- acaggua agcuacucccucaacuaggugggguucgugcggaugggugggaggggagagauuagggucccuccucccagagg- cacugc ucuaucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuu- cacccc gacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcucca- cggaagg aggaguuccugagcgagccugggcucugagcaggccauccagcucccaucuggccccuuuccaguccuggugua- agguuca accugcaagccucaucugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauac- caagacc uaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuugg- cagagcu uuccugaggaagauuugcagucccccagaguucaagugaacacccauagaacagaacagacucuauccugagua- gagaggg uucucuaggaaucucuauggggacugcuaggaaggauccugggcaugacagccucguaugauagccugcauccg- cucugac acuuaauacucagaucucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagau- guugccuc acuuugaguuguaugaacuucggagacauggggacacagucaagccgcagagccaggguuguuucaggacccau- cugauuc cccagagccugcuguugaggcaauggucaccagauccguuggccaccacccugucccgagcuucucuagugucu- gucuggc cuggaagugaggugcuacauacagcccaucugccacaagagcuuccugauugguaccacugugaaccgucccuc- ccccucca gacaggggaggggauguggccauacaggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcg- ugguga cugacugucuucugccuggaacuuugcguucgcgcuuguaacuuuauuuucaaugcugcuauauccacccacca- cuggau uuagacaaaagugauuuucuuuuuuuuuuuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguaugu- uuguu ucaaauaauggggaaaguaaaaagagagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Il12rb2/ 3 Sequence below. 263 Interleukin 12 receptor, beta 2 U64199 cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccu- cucugcg uccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuag- agaaug cucauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacug- ugaccg uccagccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcugu- ucacauu aucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaa- guccaug accacacuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcua- aacugua gcaacucucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccu- caaaaca uaucauguguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaa- accaauu acacuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugc- aaucgcc uggaucuugggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgau- cuuggaa auucuucuucacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaauc- aacuuuc uaaaugcuucugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauau- cagccuc uuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccg- uuuacaga auaugaauuucaaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaa- cacgaac accagaggaagagccuguugggauauuagacaucugguacaugaaacaagacaucgacuaugacagacagcaga- ucucucu uuucuggaagagucugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagagguga- caaagaa aacaacacugcagaauacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcau- cagugucu gcagccaacucaaaaggcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggc- uccucac caggucucugcaaagucggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugc- uguucgg gaguacauaguggaauggagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccc- cccggaca acaugucugcucugauuucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagag- agccaag gagggugcagcuccauccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucaca- gagaaaaa ggaacgccuuuucauuuccuggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauau- acuggaa agaacgagacucgacagcacaaccugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaa- gcagccuac agcccagggugacauauguccuauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagg- gaauuuu guccacagggcaaagccaacuggaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacg- uucucaa uucguuacuuccggcaaaaggcauuuacucuccugucuacucucaaaccucaaugguauagcagaaccauucca- gauccagc aaacagcacuuggguaaagaaguaucccauucuggaggagaagauccagcuaccuacggauaaucuccugaugg- cauggcc cacuccugaagagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccau- auuacuuc aaaagaggccaaggauuccaaggcuacucuaccuccaagcaagaugcaauguauauugccaauccacaagcuac- aggaacuc ucacagcugagaccagacaacuagugaaccuauacaaggugcuagaaagcagagacccugacucaaaacuggcc- aaccugac cagccccuugacagucaccccagugaacuaccuuccuagccaugaaggcuauuuacccuccaacauagaagauc- ugucacca caugaggcugacccaacugauucuuuugaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguuc- ucuccgc ccacucaucuucgguggugagcggcugacucuagaucgguuaaagaugggcuaugacucccucaugaguaauga- ggcuug auacuagaaagccaacguaccucauuuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagc- cagcuguc ucuggauaaaguuagcuucaccauagguacuuaagucuuauggauaagguggcaauacaccaacacugauauca- uauagaa aggaccccaagauagucaugcuc Wnt10a/Wing- 3 Sequence below. 264 less-related MMTV integration site 10a U61969 ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggac- ucaguggc cucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacauggggggg- gggggu acagaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccg- cgcccgcc ucgcacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccucc- agucccc agcccgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaag- gggcccuu gggaaauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggug- cccgggg gcgcugccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucg- cagccg ccccaccccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccugg- ccugucac ggcccgcgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccuga- guucugg gcgcuccuguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccg- ccuaccc ccagagcccgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugug- ugugcgu cacccugacguggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccggga- ccagcgc uggaacugcuccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgaga- gagugcu uucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggc- uugcgg uugcgacgccuccagacguggggacgaagaagcuuuccgucggaagcugcaccgcuugcagcuggacgcgcugc- agcgcgg aaagggcuugagccacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccuggg- agugggg uggcugcaguccggaugugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagag- acaucca ugcucgaaugagacuccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaau- gccacgg caccucaggcagcugccagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugc- gcaaccg cuuccaccgcgccacgcucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcac- ccucgcca gcaccgggcacuccagggcugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuu- cugugag cgcgagccgcgccuggacucggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcug- cggcagc augugcuguggccgcggccacaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggug- cugcuuc guggucugcgaagaaugccgcaucaccgagugggucagcgucugcaagugagcagacccaagcuccucuggguc- ucaagaa ugguuguccucuuggugccuggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccu- gagaga ggugguuggcucuuacagccccgagggucuacaaucaccagacaguccagaucugauugacauuccuccgcuca- ccucugu agguuccccucuuucuguuccuagcucagacagcugggggugauaguggagacuguuccacacccuaggacagg- ucaccaa agcagcccagccuggcaugccuaccuccugucaucucuucuucccuuccccaggagugauaggcaaugcacuga- agcugau gggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccu- cugcucc ugucuuucacuuaacagauauuuauuuuugcgcucucuuugagacacucucuggggaaaaagaagcuccggagu- cuacag gcugauuaagggacauggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa Ifngr2/Inter- 3 Sequence below. 265 feron-gamma receptor precursor M28233 gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcgggucc- ccuguca gaggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcug- ucugcg aaggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucu- aauuaag ucuuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacaggu- aaaggug uauucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuaugua- uccuga uguaucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguucc-

uuaugug ccuaaagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguau- uucaccc ugaagucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuaua- cugugu auguggagcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacu- cugugug aguuaaacaucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaa- guuagaa cagaaaaaucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguu- gcuccuc uuaccgucuuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagc- auaaugu uaccuaaguccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuuguc- acaccgc accagccagcuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagc- cccgaagc agcagaacaggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccag- acagcccu ccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccua- ucacuccc gaaacggcucugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaacaacaac- ucagaaac aaagauggcagagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacaugu- ugguggac gugcuuguggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccua- aggucu cccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuau- acauua gcuaauacuaaccacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacuc- ugcaaau gccaagacuaucaaaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccuc- ggcuag ccuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuu- uuuuuuc acacaccuuuguauauguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaa- gccagcc guaagucuaugguagaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuugu- acauac uuuuuuauggagcauuacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc Fgfbp1/ 3 augagacuccacagccucauccugcucuccuuccuucuccuggcuac 266 Fibroblast ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccac growth factor acagcacagcggaggaggggguagaggguucagcucccucguuagg binding protein gaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgc 1 auggcaaguuugucaccaaagaccaagccacaugcagaugggcugug AF065441 acugaggaggagcagggcaucagccugaagguccagugcacacaagc cgaucaggaguuuucuuguguuuuugcuggugacccaacugacugc cuuaaacacgacaaagaccagaucuacuggaaacagguugcccgcac gcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuuga agaccagagugugcagaaagagauuuccagagucuaaccucaagcug gugaaccccaacgcacguggaaacacgaagcccaggaaggagaaagc agaggucuccgcaagggagcacaacaagguccaagaagcugucucca cggagccaaacagggucaaagaagacaucacacucaauccagcugcg acccagaccauggccauuagagauccagagugucuagaggauccaga ugugcucaaccagaggaagaccgcccuggaguucuguggggaaucu uggagcuccauuugcacauucuuccucaacauguuacaggcgacauc augcuaa Transcription Factors and Related Genes Klf5/Kruppel- 5 aauucgucgacaugcgccguuccagugcauggugugccaacgcagc 267 like factor 5 uucucccgcuccgaccaccucgcgcugcacaugaagcgccaccagaa AA611766 cugagcgagcgagcgcugccccacccgccugacgccuugcaguccgc ucugccauccuuuaaaccgcagaccuaacuucauaaaaaga Gata3/GATA 4 Sequence below. 268 binding protein 3 X55123 gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaac- ugcaaaca aaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccu- cuacccgc gagguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcuggg- ugagcc accaucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaa- gcucagua uccgcugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaa- acuccgu cagggcuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggau- cucugcc cuggcuggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaaga- cguccauc caccacggcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccag- uccucau cucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgg- gucggcca ggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucu- cgaggca gcaugaccacccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgag- uacagcuc uggacucuucccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcac- gauccag cacagaaggcagggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacu- accuuug caaugccugcggacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucgg- cagcaagg agagcagggacauccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggaccc- ggucugca augccugugggcuguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacc- cgaaaccg gaagaugucuagcaaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccu- ucaacccg gccgcucucuccagacacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccac- accgacgcc caugcauccgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagag- gcagagcc cugcuccacaugcgugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcag- gagcagu aucaugaagcccgaaagcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaagg- agcucga gguggugucugcauuccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauu- uaacagg gucucuagugcugugaaaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuuga- ggaagac uuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaag- uaugga gauacagaagaaaccacuaagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugau- gcauuua aaaaaaaaaaaaagaaagaa Stimulated by 3 Sequence below. 269 retinoic acid 14, basic-helix- loop-helix protein Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugccca- cauguacc aaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcug- auugagaa aaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacua- cuuuggg ucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagc- agcagca gaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaa- uguucu gcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaa- ucuuccc agcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucg- gcuccca aagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugcca- gucaucca gcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaau- uggaga aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacguguc- agcacaa uuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcg- ggcaguga ucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccac- caucggc cacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaaca- ccucagcu gcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucucc- uuuggcac auucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagac- uaaacuc uggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcaga- gagauca gcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuug- uaugua uguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagauga- cagacug gaggacuguagcacaucucugggcguuucccuacccagagaagagcc Cell Cycle Related Mki67/antigen 4 Sequence below. 270 identified by monoclonal antibody Ki67 X82786 agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccc- cccccuc gaggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggc- cgcggg uggccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccag- agcuaa cuugcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgccc- ugguccg cagucccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggc- gcacacu ucccgcugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagug- ucucaa agacauugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaagu- aaacggg guuacuauagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguauga- agaugga aaucaugaggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccuc- aagagaua gcuucugugcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuu- guguaug ccaagggccuuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcau- guagaac agcacacuggcagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagca- guuacag ggaaccgaagucuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuau- caaucaau gaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagagg- aaucgcg ggagacacagcuauuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuu- cacccaa aguaggaaagaucuggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaa- ugaagac cccugugcggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucugg- augaagg uggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggagg- cugggga uguuggcagccccgcugauacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuc- caucugca gagacacaaaaucggcucucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucag- caagccug agaaacuggccacagccgccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuu- ggugauu ccauuaacaagagugagggaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauua- uuugaug aaaacuugccuccuaauacaccacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagc- ccagcugu ccucaagacaaucaucaaggaacggccccagucuccagggaaacaagagucuccugggauaacgccaccgagga- caaaugau caaagacgcagaucaggcaggacuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcagg- caggaaga gcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaa- aggcgaa guggagcuucugaagccaacuugauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaaca- caaacga aaguugcgaaacaugucccuccaaagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccaca- agcaaucuu cacaaucaauuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaagu- aagugug ccugcccgacccuacaaaaugcugaauaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucagg- acuaacug aaauguucaagacuccagugaaggagaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcg- aauuugu cugaaagacaauugcaaguaacuaauucaggagacauaccugagcccaucaccacagagauuuugggagaaaaa- gugcuauc caguacucggaaugcagcaaagcagcagucugauagauauucugcaaguccuaccuuaagacggcggagcauca- aacaugaa aacacagugcaaacuccuaagaauguccauaacauuacugaccuugagaagaagacuccggucucugagacaga- gccccuga 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aggaauua cagaaaagaaagugaacauaauaguauaugcaaccaaagagaagcacucgccaaagaccccuggcaaaaaggca- caaccucua gaagggccagcuggucucaaggaacacuuugaaacaccaaaccccaaagauaaaccuauaacggaagacagaac- uagagucc uuugcaaaucaccacaagucacaacagagaauaucacaacaaacacaaagccacagacuagcacaucugggaag- aaaguagac augaaggaagaaagcucugccuugacaaaacguauacauaugccaggggaauccaggcauaaucccaaaauuuu- aaaacuug agugugaggauaucaaagcuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaauggaagcaagagg- acuuuag gaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuuccaggaacucuuuauaucaccaguuccu- acuaacau aaucaaaaaaauucccagcaaaucuccacacacacaaccagucagaaccccagcgagcacaaagagacucucca- agacagguc ucaguaaaguggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccaggc- acaccagc accagugcaggaagaaaaugacugcacagccuacauggaaacuccaaagcagaaacuggagucuauagaaaauu- uaacaggg cuuaggaaacaguccagaacaccuaaagacaucacugguuuccaggauaguuuccaaauaccagaucaugcuaa- uggcccau uagugguugucaaaaccaaaaaaauguucuuuaauucuccacaaccagaaagugccauaacccgaaagagcaga- gagagaca gucuagggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauuaggag- aaggugu agacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccugcaaagcguaaacuggauucaa- cagcuggu augccuaacagcaagaggaugcgcuguucuucaaaggauaacacaccaugccuagaagaccugaauggcuucca- agagcucu uccaaaugccaggcuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaauua- ggaccagu uagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggaugugacagaagaaauuucag- gucucugg aagcagucacugggcagaguccacaccacacaagagcaggaggauaaugcaaucaaagcaauuauggagauucc- aaaggaaa cacugcagacugcagcagauggaacuaggcuuaccagacagccacaaacaccuaaggaaaaaguucaaccgcug- gaagauca cagugucuuccaagaacucuuccaaacaucacgcuacuguucugauccauuaauugguaacaaacaaacaagaa- uguccuug agaucuccacaaccaggauuuguuagaacuccacgaaccucaaagagacuggcuaagacaaguguugggaauau- ugcugug agagaaaagaucucuccagugagucugccacagugugcuacaggggagguuguacacauacccauagggccaga- agaugac acagagaacaaaggugugaaggaauccacaccucagacacuggacucaucagcaagucgaacugucagcaagag- gcagcaag 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aggucauguaagaaaaggucccaguccccagaagaccucucugguguucaggaggucuuccaaacaucaggcca- uaacaag gauucagugacaguggacaaucuugcaaaacugcccagcucgucuccaccacuagagccaacagacacuucagu- aaccucac ggagacaggccagaacuggucugaggaaaguucacgugaaaaaugaacuuucaggaggcauaaugcauccacaa- auaucag gggaaauuguggacuuaccuagagaaccagaaggugaaggcaaagucauuaaaacaaggaagcaaucuguaaaa- cggaaau uggacacagaagucaaugugccucgcaguaagaggcaaagaauuacaagagcagaaaagacccuagaggaucug- ccuggcu uccaagagcucugccaagcuccaagcuugguaauggacucaguuauuguugagaaaaccccaaagaugcccgac- aaaucucc agaaccuguggauacaacuucagagacacaggcaagaagaagacucaggagacugguuguuacugaagagccca- uaccacaa agaaagacuacaagaguuguaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguaugga- agaguuua aggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaag- gagaaaac ccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccgg- aagagaagg aaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagcccacagca- cagagaaa gcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaagagguuaaga- agucuaca aagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcaca- ggcccuag aauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagcaagugauaaaggacccaca- cagaugcc cuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaaggcgacccaggacaagacguggga- aaguagag gcagaugaagagccuucagcaguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaagguccc- ugaaauug guaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagauacaguagccaaaguaacuggcagc- aggaggca gcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugacuccaaagaaauaacccaaauau- cagaucac ucugagaaacuagcacaugacaccaguauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucu- gagaacau gcagaagagugcugagggccucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauua- caaagca aaagcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgc- ucuuuag caccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguaugua- ucaccuga gccugugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguua- ugaaaac agaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaaug- uaaaacagc caaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucc- caggagac agagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcu- ugagguc uagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuuga- uaaagccu caggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuugga- caguga accuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugca- ccaagaag uuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaaggaaa- aguaaauu ugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuacugcuacugcc- ugaguu uaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucacca- gggaucu cagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauuc- gcugcca aaa Cks2/CDC28 4 gacguagagccccuugcgcccgguuuccugaucccgcuuacuc 271 protein kinase cucugcgcgccggcaggauggcccacaagcagaucuacuacuc regulatory agacaaguacuucgaugagcacuacgaguaccggcaugucaug subunit 2, sim uuacccagagaacucucuaaacaaguacccaaaacucaucugau to cdk guccgaagaggaguggaggagacuugguguccaacagagucu regulatory aggauggguucauuacaugauucaugagccagaaccgcauauu subunit 2 cuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaa AA681998 gugcagcugggaucaucuaaucuuuuucaaauuuaauguaua uguguauauaagguaguauucagugaauacuugaaaagugua caaaccuuucauccauaccugugcaugcgcuguauucuucaca gcaacagagcucagucaaaugcaacugcaaguagg Ccng2/ 3 Sequence below. 272 Cyclin G2 U95826 cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucga- acggucc gacgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagg- uggcgaa gggguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcu- gaucuug auggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaag- uuuaacu aacuucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaa- ggugaa accgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacg- uuccccc cacgcacgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucu- cagagaaa cugcacuaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacac- uucagaa aggaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucuccaa- agcaaga ccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaauucu- cuugcuu guuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuagcaga- guauucu ucgccucgcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccucca- cagcagc uacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugaggacucugg- ugaaga caugaguuguggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuugacuucc- aaguggc ucagacacugugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaaguguguguaccu- agguuu caaagcaauaaacuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg Prc1/Protein 3 aacuaccuugggcagguucuauuaacugcaccuaacucagacg 273 regulator of ugaguaggacagaaggaagcugucccgggcgaacugaggucac cytokinesis 1 aaagacuugcuuuugauucaagagagaccuuaaaggcuaguua DNA segment, ugauaguuaaguacaaguuuuaacaucugguagcuaacuuuu Chr 7 uuucucuaccccguaauucuacuaugacugcucuucuagagg AA856349 uccugaguucaaaucccagcaaccacaugguggcucacaacca ucuauaaugggaucugaugcccucuucuggugugc

[0218] Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.

Example 10

Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF

Materials and Experimental Methods

[0219] In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.

Results

[0220] A 1 cm.sup.2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).

[0221] In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.

[0222] The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.

Example 11

Inhibition of EDIHN by Epidermal Growth Factor Injection

[0223] 21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently reepithelialized, 10 .mu.L of 1 .mu.g/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).

[0224] In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.

[0225] The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.

Example 12

Enhancement of EDIHN by Inhibition of EGF Receptor

[0226] To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 .mu.M in 10 .mu.L volume) was administered as a single injection 11 days after incisional wounding (1 cm.sup.2) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.

[0227] The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.

Example 13

Enhancement of EDIHN by Expression of a .beta.-Catenin Activator

[0228] To determine the effect of administration of .beta.-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the .beta.-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).

[0229] Thus, administration of .beta.-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

Example 14

Enhancement of EDIHN by Administration of FGF

[0230] To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.

Example 15

Enhancement of EDIHN by Administration of Edar

[0231] To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that enhances signaling by ectodysplasin.

Example 16

Enhancement of EDIHN by Administration of Minoxidil

[0232] To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.

Example 17

Removal of HF by Abrasion and Administration of EGF

[0233] Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.

Sequence CWU 1

1

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uuuggcugau ccaugcaggc agguaguggu acagugcugc ugaaaggaag 2040aaguucccca uuuuaucugu uaaaacacca gagacauggg caagugcuaa uggaccucac 2100uucaggaaga gggucugcuu ccugaagcca gugugugaug aaaagugacu gagaccugau 2160aucuaaggug agaccugaua ccuaacacuc ugucacacag uccagggcca acagugcuau 2220aggaaagucu agaagaaaac aucacaucag uauuuuagaa ccaucaacca ucucuugucc 2280cuauagccca auccagaggc cugguuuuua gaacuggcug uguaaggugc caaacacuca 2340guucacuugu agaaucagag ccuuuuuucc ccccuauguu aauugaacac gcgcucugag 2400cuguuuuguu gaaguagaaa aucucauaga aaaaucacug uagaucuacu gaccuauagc 2460ccucuggaaa ugccuuugag augguuuuac uuuucuaggu cauagaugcc ugauuauaaa 2520gaugaacaau aaaaucagcu uucuuucuuu cucuucugau cuuauucccc agaucugauu 2580caggccaugu uccaaagcaa ggcuacauug agguccuggu gucuuuaagu aaaggacauc 2640uuucagaucc ucucaaagaa ggauuuauaa caguuuccag augaauguac uaauagcuuu 2700gggugccuua ucucuuuccu aaucuguagu gccugugagc ucagucucac uccuucccuu 2760agcccggaga ccccuuagau cgagugggaa uagucaagag gcuggcugga gagucaucag 2820uacauugguu ugcagaaauc uuuuacaggc uacauuuugg aauuuuuuuu uuuuuaguaa 2880gugaucaaau uuggugggaa guaauucgag uguauucgau uguauugucg uccucguuau 2940cauugucaaa cauguuauag acggcaguug gcacuggggc ugcuaaucuc uggguguagu 3000cucugaaacu guagcuccag ugagguggug ugaaagguua gcaaagccac caucugcugg 3060ugcuccagcc aaggugccuc uuagccacug aauugcuaug uuauccuuuc ucuuguaaca 3120aacccacccc agagauaaag ccuuuaauca acccaagaaa cuccugggcu aaguaucuga 3180cagucucaca ucucaacagu gugaauuaag uguccauagc aucagcucag gaggacacuc 3240ugggagagug cugacaaaaa aggguuauua auacugaccu acuacuucaa gggcaguucu 3300gaggugauua gagcuuuuuu uaaaaaccaa guauuugggg auccucagca gagguauuca 3360uacagacucc caaagaacua uauauguucc ugagaccauc guuuagucua cauugcucuu 3420cccagagacu gacagauaug accagucaaa gugcaagacu accuacccac ugccaugaaa 3480accauugcag gaaaccuuuc ccuuccugaa ugagauuuuu uuuuucccuu uuuauguggg 3540guaauuauuu gugacccaag uguaauuugg augauuucca uuaauaucaa cucuugaagc 3600cuacuuguac ugauugagau uguauuuguu ccuaauaaaa guggaucugg uuguacuguc 366012429RNAHomo sapiens 12accacuugca gacaaaugaa uuccuucgaa auguauuuga gguuggaccc ccugugaugc 60uugaugcugc aacacuuaaa accaugaaga uuucucguuu ugaaaggcau uuauauaacu 120cugcagcuuu caaagcucga acaaaagcuc gaagcaaaug ccgagauaag agagcagaug 180uuggagaauu cuuguagaug ucugaauuug auggcuguuu ucuaaucucu uccuuuauua 240uuauuuuugc uacuucuaau guauauaagc uuuuagagac aguuuuuuau cuuggucaac 300uuaaauaauu uuugauguag ggguggguug uauuuuaauu uaauguacag uguuacaaau 360uaaugaguuc uuuauucucu guaaaaauaa cugguaacca caaauaaagu guuugugaug 420uuuggucgu 429131639RNAHomo sapiensmisc_feature(1003)..(1003)n is a, c, g, or umisc_feature(1098)..(1099)n is a, c, g, or umisc_feature(1106)..(1106)n is a, c, g, or umisc_feature(1112)..(1112)n is a, c, g, or umisc_feature(1158)..(1158)n is a, c, g, or umisc_feature(1161)..(1161)n is a, c, g, or umisc_feature(1171)..(1171)n is a, c, g, or umisc_feature(1182)..(1182)n is a, c, g, or umisc_feature(1245)..(1245)n is a, c, g, or umisc_feature(1436)..(1436)n is a, c, g, or umisc_feature(1472)..(1473)n is a, c, g, or u 13auguccgcgg ccgccuacau ggacuucgug gcugcccagu gucugguuuc caucuccaac 60cgcgccgccg ugccggagca cgggggcgcu ccggaagccg agcggcugcg acuaccugag 120cgcgagguga ccaaggaaca cggugacccg ggggacaccu ggaaggauua uugcacgcug 180gucacuaucg ccaagagcuu guuggaccuc aacaaauacc gacccaucca gacccccucg 240gugugcagcg acagucugga gagucccgau gaggauauag gauccgacag cgacgugacc 300accgaaucug ggucgagucc uucccacagc ccggaggaga gacaggauuc uggcagcgcg 360cccagcccac ucucccuccu ccacucugga guggcuucga aggggaaaca cgccuccgaa 420aagaggcaca agugccccua caguggcugu gggaaagucu auggaaaauc cucccaucuu 480aaagcccauu acagagugca uacaggugaa cggcccuuuc ccugcacgug gccagacugc 540cuuaaaaagu ucucgcgcuc ggaugagcug acccgccacu accggaccca cacuggggaa 600aagcaguucc guugcccacu gugugagaag agauucauga ggagugacca ucucaccaag 660caugcccggc gucacaccgu guuccauccc agcaugauca agagaucaaa aaaggcucuu 720gccugccccu ugugaggugc uccccauggc agccaggcag agaugggucc ccggaaggac 780agagcuccca ggaaacagac ugacacaugg aaaucugcca cagcagaggc gcgcuggcca 840caggagguca

cugcuucuuu ggccaauauu cugauaucuc ccugcacugu uuccaaaaag 900cacaugguag cccuaagguc aaagucaaca uuuggucccc uugcagaggc aacucugaac 960cgucucugac ugaagauuca gacugguggu guacauacgu cunacugggu gaguugaccc 1020cuggccuccc acagugcaga accacucucu ugaaucacau uaacuuuuga gauuuaaaaa 1080aaacccaaac ccaacccnnc aaaacnccag anacaccgaa acucuggauc cucgaugcuu 1140gcugacucuc agaauugnuu nuucuucuca nuuaugcaag cnagagcaca ccuacuccag 1200caugauuugu caucuaaaga cuugaaaaca aaacaacaac aacanaaagu uacuuauagu 1260caauggauaa gcagaguccg aauuuacacu aaucaagaca gaccuucgag gggucacgau 1320aaguccggaa cuuucaaacc uugcuucgua ugaauuguac uaucugaaca uaaacugcac 1380uuuuauuuuc uaauaccgag ggugaauacg guaaauacau gcuuugaggg uagaanccga 1440cggucuguuu ggcaccacgu uauaaucugc unnuuuuaac gaguaccacc uuggagggca 1500ggcaaauaaa ugcuuuuggg uauuuucucc uuuguuuuug acaaaugcug cggauggggg 1560aucgggaucg gaggggagug cuuuuaaaga uaauaaaaaa ugagguaaau aauuuuaacu 1620uaugaauuug uuugaauuc 1639141929RNAHomo sapiens 14gagauugaaa caauggaaga acuuuccaug gcaaacacca uguuugcccu caaucuccuu 60aagcagauag aaaaaucaaa cucuacccag aacaucuuua ucucuccaug gagcaucuca 120ucaacauugg ccauaguucu ccucggugcu ggggguaaca cugaacagca gauggccaaa 180gugcugcagu uuaaugaaau uggcaguuau gguaucacca caagaaaccc agagaacuuc 240aguggcugug auuucgcaca acagauacag aaggaaaauu auccuagugc uauuuuacag 300gcacaagcag gagauaaaau ccauucagcc uucuccucuc ucagcucaac aaucaacaca 360ccacaggggg auuauuuguu agaaagugca aacaagcugu uuggagagaa gucugcaaga 420uucaaagaag aauacaucca acucucuaag aaauauuacu caacagaacc agaagcagug 480gacuuccuug aaugugcuga agaagcuagg gaaaagauua auucuugggu caagacucaa 540accaaaggug aaaucccaaa ccugcuaccc gaagguucug uagaugaaga caccaagaug 600gugcugguga augcugucua cuucaaagga aaguggaaaa cuccauuuga gaagaaacuu 660aaugggcuuu auccuuuccg ugugaacucg caugagagca uaccugucca gaugauguuc 720cuccaugcaa agcugaacau uggauacaua aaggaccuga agacucagau ccuagaacuu 780ccgcauacug gaaacaucag caugcuccug uugcuucccg augagauuga ggacgcaucc 840acuggcuugg aauugcugga aagugaaaua aacuuugcca acuucaacaa guggaucagc 900aaagacacac uggaugaaga ugauguugug gucuacauuc ccaaguucaa acuggcacaa 960agcuacgaac ucaaguccau ucuucaaagc augggcaugg aggaugccuu caacaagggc 1020aaggccaacu ucucaggaau gucugagagg aaugaccuuu uucuuucuga gguguuccau 1080caagccagcg uggaugucac cgaggagggc acuguggcag cuggugggac uggggcaguu 1140augacaggaa gaacuggcca ugguggccca caguuugugg ccgaucaucc cuuucuuuuc 1200uuuaucaugg acaaaauuac ccacacgaua cuauuuguug guagauucuc cucacccuaa 1260aaggggaaga ccuauuucca caugagguuu uguagcauga acuauaagcc ucagaauugc 1320aucuucaagu gccaaaaguu uaaauacuuu cuuacacauu uuuauacuuc ugcuauacac 1380uaaauauaac cuaaaagcaa uuguauagca gucuucagug cuuacaguau aacucuauua 1440augauuuugu uuccuaaagu cagaugaugu cuauuuaguu cauccuuauu acugcuuugu 1500cuuuauaacu uuaguuuuua caguguuauu uauuguuuau auaaugguug uuuuacaaau 1560uguuguccuc uguuuaauga aacuguaaca cuacagaagc agaaaauuag auaauuuucu 1620auuuaaagaa aaucagccau uuaauuuaau aaugaaggaa aaauaugagu cuuccauacu 1680uucccaugau auucacccag aaaaaaugua cuuaacaaaa gacauguuau aucucuauca 1740uuauauauca uauguacgua ucugcaacuc aucuauaauu aggacuacau cauaaguaag 1800caugcuuacu uacacacugc uaucuguugu auaaaacuua gcaauccuua uuuguuaguu 1860aucuuucuau cacuguaaca aaauaccuga gauaauaaag uucaaagauu uauuuugaaa 1920aaaaaaaaa 192915284RNAHomo sapiensmisc_feature(16)..(16)n is a, c, g, or u 15uuuuuuuuuu uuuuunuaag aauuaacuuu uauuuuugcu uaguuuuauu aaaaaaauaa 60auaugucaua aagcuuuugu uuccuuuagg gagaaaaaaa aggaacaagu uccauaaaau 120caaacaagca augguaacau gucuuaacuu gaaaacaacu ggggucacug guuuacaagu 180uauaacugaa ugaaugacug ccacaguugc ccauuuccuc cugccaaugg cagcaaacaa 240caggaucaac uagggcaaaa uaaauaauug uguggaagcc cuga 28416219RNAHomo sapiensmisc_feature(70)..(70)n is a, c, g, or umisc_feature(88)..(88)n is a, c, g, or umisc_feature(132)..(132)n is a, c, g, or umisc_feature(205)..(205)n is a, c, g, or u 16aacuaaacuu ccuuguaacu uuugagaacu cagcucuggu acuuuuucau gccuugcaaa 60auggcguuan ugcagcuagc uugcuaancc uuaugguggg gucuuucauu ccccccucuu 120ucuggaaacu gnauaaaauc auuuauucac gugauucuau uucuucugga ucuauugauu 180ugaguuggug auacuguugg gucanaacca gggccuguu 219174179RNAHomo sapiens 17cagcuccgag cuaggugcua ucgcaaggcc agagcgcaca gcccggcgga gagagcagau 60ccuugcucag aucgagucaa aucgggccaa ggcggaggac gaagagucca ggcuccuauu 120cuggacuugu uccccagcuc cgggggcgcu ucuagguccu gcagcagcca gcagugcgga 180gccaccaacu cggugcugga augaaaaaau ucccgcgcgc cagugcagaa ucuuucuaag 240ugacccggag cuucgggugc uagcucugca cgaacuuucc caucaaagug aucgugaauu 300uuaagcauca ggagcaggcc agcgaagcuc uacgcgucua aacgucuauc cagaccaaga 360guucucugcg gugcagggug cggugccaug cagccaaaag ucccuuuugg ggucacgcaa 420gcagaagccc ugcuccgaca ugggggacgu ccagcgggca gcgagaucuc ggggcucucu 480guccgcacac augcuguugc ugcuccucgc uuccauaaca augcugcuau gugcgcgggg 540cgcacacggg cgccccacgg aggaagauga ggagcugguc cugcccucgc uggagcgcgc 600cccgggccac gauuccacca ccacacgccu ucgucuggac gccuuuggcc agcagcuaca 660ucugaaguug cagccggaca gcgguuucuu ggcgccuggc uucacccugc agacuguggg 720gcgcaguccc ggguccgagg cacaacaucu ggaccccacc ggggaccugg cucacugcuu 780cuacucuggc acggugaacg gugaucccgg cucugccgca gcccucagcc ucugugaagg 840ugugcguggu gccuucuacc uacaaggaga ggaguucuuc auucagccag cgccuggagu 900ggccaccgag cgccuggccc cugccgugcc cgaggaggag ucauccgcac ggccgcaguu 960ccacauccug aggcgaaggc ggcggggcag uggcggcgcc aagugcggcg ucauggacga 1020cgagacccug ccaaccagcg acucgcgacc cgagagccag aacacccgga accaguggcc 1080ugugcgggac cccacgccuc aggacgcggg aaagccauca ggaccaggaa gcauaaggaa 1140gaagcgauuu guguccagcc cccguuaugu ggaaaccaug cucguagcug accaguccau 1200ggccgacuuc cacggcagcg gucuaaagca uuaccuucua acccuguucu cgguggcagc 1260cagguuuuac aagcauccca gcauuaggaa uucaauuagc cugguggugg ugaagaucuu 1320ggucauauac gaggagcaga agggaccaga aguuaccucc aaugcagcuc ucacccuucg 1380gaauuucugc agcuggcaga aacaacacaa cagccccagu gaccgggauc cagagcacua 1440ugacacugca auucuguuca ccagacagga uuuauguggc ucccacacgu gugacacucu 1500cggaauggca gauguuggaa ccguauguga ccccagcagg agcugcucag ucauagaaga 1560ugaugguuug caagccgccu ucaccacagc ccaugaauug ggccaugugu uuaacaugcc 1620gcacgaugau gcuaagcacu gugccagcuu gaauggugug aguggcgauu cucaucugau 1680ggccucgaug cucuccagcu uagaccauag ccagcccugg ucaccuugca gugccuacau 1740ggucacgucc uuccuagaua auggacacgg ggaauguuug auggacaagc cccagaaucc 1800aaucaagcuc ccuucugauc uucccgguac cuuguacgau gccaaccgcc agugucaguu 1860uacauucgga gaggaaucca agcacugccc ugaugcagcc agcacaugua cuacccugug 1920gugcacuggc accuccggug gcuuacuggu gugccaaaca aaacacuucc cuugggcaga 1980uggcaccagc uguggagaag ggaaguggug ugucaguggc aagugcguga acaagacaga 2040caugaagcau uuugcuacuc cuguucaugg aagcugggga ccauggggac cguggggaga 2100cugcucaaga accuguggug guggaguuca auacacaaug agagaaugug acaacccagu 2160cccaaagaac ggagggaagu acugugaagg caaacgaguc cgcuacaggu ccuguaacau 2220cgaggacugu ccagacaaua acggaaaaac guucagagag gagcagugcg aggcgcacaa 2280ugaguuuucc aaagcuuccu uugggaauga gcccacugua gaguggacac ccaaguacgc 2340cggcgucucg ccaaaggaca ggugcaagcu caccugugaa gccaaaggca uuggcuacuu 2400uuucgucuua cagcccaagg uuguagaugg cacucccugu aguccagacu cuaccucugu 2460cugugugcaa gggcagugug ugaaagcugg cugugaucgc aucauagacu ccaaaaagaa 2520guuugauaag uguggcguuu guggaggaaa cgguuccaca ugcaagaaga ugucaggaau 2580agucacuagu acaagaccug gguaucauga cauugucaca auuccugcug gagccaccaa 2640cauugaagug aaacaucgga aucaaagggg guccagaaac aauggcagcu uucuggcuau 2700uagagccgcu gaugguaccu auauucugaa uggaaacuuc acucugucca cacuagagca 2760agaccucacc uacaaaggua cugucuuaag guacaguggu uccucggcug cgcuggaaag 2820aauccgcagc uuuaguccac ucaaagaacc cuuaaccauc cagguucuua ugguaggcca 2880ugcucuccga cccaaaauua aauucaccua cuuuaugaag aagaagacag agucauucaa 2940cgccauuccc acauuuucug agugggugau ugaagagugg ggggagugcu ccaagacaug 3000cggcucaggu uggcagagaa gaguagugca gugcagagac auuaacggac acccugcuuc 3060cgaaugugca aaggaaguga agccagccag uaccagaccu ugugcagacc uuccuugccc 3120acacuggcag gugggggauu ggucaccaug uuccaaaacu ugcgggaagg guuacaagaa 3180gagaaccuug aaaugugugu cccacgaugg gggcguguua ucaaaugaga gcugugaucc 3240uuugaagaag ccaaagcauu acauugacuu uugcacacug acacagugca guuaagaggc 3300guuagaggac aagguagcgu ggggaggggc ugauacacug agugcaagag uacuggaggg 3360auccagugag ucaaaccagu aagcagugag guguggcaag gaggugugug uaggggauac 3420auagcaaagg agguagauca ggacacuacc cugccaguua cauucugaua agguaguuaa 3480ugaggcacag uagcaucuga aagaccauac agagcacuaa ggagccccaa agcacuauua 3540guaucucuuu ucuuauaucu aucgcccaaa uaauuuucag agucuggcag aagcccuguu 3600gcacuguacu aacuagauac uucuuaucac aaagauuggg aaaggcaaag cagaaagaug 3660guaagacugg guuucaaaca aggcuugguu ucaaucacug gaggcaagga ggaggggaca 3720aacaagauca uuauucgaag ucgcugguug cugugguuuu acggaagguu gaugcaucau 3780uccuaucaac agugaaaagu ucagcuuguu caacgugaca gaaaggcuca ucuccgugaa 3840agagcuccug auuucuucuu acaccaucuc aguucuuaac uauaguucau guugagguag 3900aaacaauuca ucuauuuaua aaauguacau uggaaaaaaa aagugaaguu uaugagguac 3960acauaaaaac ugaaggaaac aaugagcaac augccuccug cuuugcuucc uccugaggua 4020aaccugccug gggauugagg uuguuuaaga uuauccaugg cucacaagag gcaguaaaau 4080aauacauguu gugccagagu uagaaugggg uauagagauc agggucccau gagaugggga 4140acauggugau cacucaucuc acaugggagg cugcugcag 4179181416RNAHomo sapiens 18ccgcgggccc gcguucaugc accgccugcu ggccugggac gcagcaugcc ucccgccgcc 60gcccgccgcc uuuagaccca uggaaguggc caacuucuac uacgagcccg acugccuggc 120cuacggggcc aaggcggccc gcgccgcgcc gcgcgccccc gccgccgagc cggccauugg 180cgagcacgag cgcgccaucg acuucagccc cuaccuggag ccgcucgcgc ccgccgcgga 240cuucgccgcg cccgcgcccg cgcaccacga cuuccucucc gaccucuucg ccgacgacua 300cggcgccaag ccgagcaaga agccggccga cuacgguuac gugagccucg gccgcgcggg 360cgccaaggcc gcgccgcccg ccugcuuucc gccgccgccu cccgccgcgc ucaaggcgga 420gccgggcuuc gaacccgcgg acugcaagcg cgcggacgac gcgcccgcca uggcggccgg 480uuucccguuc gcccugcgcg ccuaccuggg cuaccaggcg acgccgagcg gcagcagcgg 540cagccugucc acgucgucgu cguccagccc gcccggcacg ccgagccccg ccgacgccaa 600ggccgcgccc gccgccugcu ucgcggggcc gccggccgcg cccgccaagg ccaaggccaa 660gaagacggug gacaagcuga gcgacgagua caagaugcgg cgcgagcgca acaacaucgc 720ggugcgcaag agccgcgaca aggccaagau gcgcaaccug gagacgcagc acaaggugcu 780ggagcugacg gcggagaacg agcggcugca gaagaaggug gagcagcugu cgcgagagcu 840cagcacccug cggaacuugu ucaagcagcu gcccgagccg cugcuggccu cggcgggcca 900cugcuagcgc ggcgcggugg cguggggggc gccgcggcca ccgugcgccc ugccccgcgc 960gcuccggccc cgcgcgcgcg cccggaccac cgugcgugcc cugcgcgcac cugcaccugc 1020accgagggga caccgcgggc acaccgcggg cacgcgcggc gcacgcaccu gcacagcgca 1080ccggguuucg ggacuugaug caauccggau caaacguggc ugagcgcgug uggacacggg 1140acuacgcaac acacguguaa cugucuagcc gggcccugag uaaucaccuu aaagauguuc 1200cugcgggguu guugauguuu uugguuuugu uuuuguuuuu uguuuuguuu uguuuuuuuu 1260uuuggucuua uuauuuuuuu uguauuauau aaaaaaguuc uauuucuaug agaaaagagg 1320cguauguaua uuuugagaac cuuuuccguu ucgagcauua aagugaagac auuuuaauaa 1380acuuuuuugg agaauguuua aaagccaaaa aaaaaa 141619566RNAHomo sapiensmisc_feature(154)..(154)n is a, c, g, or umisc_feature(254)..(254)n is a, c, g, or umisc_feature(262)..(262)n is a, c, g, or umisc_feature(287)..(287)n is a, c, g, or umisc_feature(305)..(305)n is a, c, g, or umisc_feature(354)..(354)n is a, c, g, or umisc_feature(378)..(378)n is a, c, g, or umisc_feature(419)..(419)n is a, c, g, or umisc_feature(449)..(449)n is a, c, g, or umisc_feature(492)..(493)n is a, c, g, or umisc_feature(521)..(521)n is a, c, g, or umisc_feature(550)..(550)n is a, c, g, or u 19aaaauguaga aggcaagauu uaauaaggca gcaacaugaa agcacacaga ccagagcucu 60ggggucgaaa uaaagcagca acauggaagc acacagagcu cuggggucga aacucauaca 120ccuuagcaca ggguagagga gucucgacgg ucanccagaa uuuuucacag gcuuauauag 180uaaaacucaa agggggagaa cugggcaggg aaaguacaag uuuacaucac uagggaguuc 240ugccaaagga caanggguuc unucagagga aucuacguaa cuaaggnguc auguccuauc 300aaggnaucua cguaacuaag gagucauguc cuaucauuug gcaauguacc cggnucuuuu 360gagguuguuc cggagggncu uauucucaaa auguuuuuca gauuggaagg gguggguunc 420cgguaaaaag uucuguuuuc aaagaggcng uaauuuucua uucuucauuc cccauucucc 480uguaaguauu cnnaucuuag aauuucagaa guccauauuc ncuauguggg gaauaacugg 540cuuuaacccn aucuuuaaaa uggggg 56620358RNAHomo sapiensmisc_feature(269)..(269)n is a, c, g, or u 20uuuuuuuuuu uuuuuuuaug aaacaguuuu guucagccca ugacuuugug caugacuguc 60guccguucua gucaccugug cucuccaucu acugccuuuu aaagcugcgu caugagaagg 120aucuacacgu 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gaugagguga guguuccucc 1500ccucagcacg cugacggcug uucuagggcu gcuuuggauc agagggauuu caguuguuua 1560acuucucaga cucggcuugc aaagcaggau cccaagaauu ugucucuggu uuguuuuaag 1620agcuuacccu uuugguugag gaaugaggga auucuagaaa uugaacccag gccuuagcac 1680auggugauaa gcacacguuc aaccauuaag cuccaccccc ucaauagcuu agacuuuuuu 1740uuuuuuuaag gaaagaauag guaagggaaa cuccuacagc cuggugcccu uguucuauuu 1800ggguuaagga gaaaaagagc ccaagaauag gaguuauuuc agcagcagcu cuccccuuau 1860cccaaugucu uggugaaguu cuaggaauuu aauaugucuu uuuccccucu cuuguuuuag 1920cugcccuaug augacugugu guuuggaggc cagcgucuga cauuauaagu ggaaaguggc 1980aaaaaagaau guggacuugu auauuuguac aaauagaguu uuauuuuucu aaaaaaaaaa 2040aaaaaaaaaa aaaaaaaaaa aaaaaguaua cuuagcacca caccacacag cgccuagacc 2100caggcauuuu acugggguga uucggcuguu gucuuuguga aauccgggg 2149222062RNAHomo sapiens 22cucucgguca cugccggucg cuuccugagc cgcugcuggc ucugugucuc uguccucagc 60guucucuucc ucguccucgu ccuaccacgc cauggaaggu uaccauaagc cagaucagca 120gaagcuccag gcccugaagg acacagccaa ucgccugcgc aucagcucca 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aagauagcca cccggaaggc cuauggacug gcccucgcua agcugggcca 1080cgccagugac cguaucauug cccuggaugg agacaccaag aauuccaccu ucucggagcu 1140cuucaaaaag gagcacccag accgguucau ugagugcuac auugccgagc aaaacauggu 1200gagcauugcc gugggcugug ccacacguga ccggacagug cccuucugca guacuuucgc 1260ggccuucuuc acacgggccu ucgaccagau ucgcauggcc gccaucucug agagcaacau 1320caaccucugu ggcucccacu gugguguguc cauuggggaa gacgggcccu cucagauggc 1380ccucgaagac cuggccaugu uccggucagu ccccaugucc accgucuuuu acccaagcga 1440uggaguugca acagagaagg caguggaguu agcagccaac acaaagggca uuugcuucau 1500ccggaccagc cgcccagaga augccauuau uuauagcaac aaugaggauu uccaggucgg 1560ccaagccaag gugguccuga agagcaagga ugaccaagug acagugaucg gggcuggugu 1620aacucugcau gaggccuugg cugcugcaga gagucuaaag aaagauaaga ucagcauccg 1680ggugcuggau cccuucacua ucaagccccu ggacaggaaa cucauccuag acucugcccg 1740agcaaccaaa ggcaggaucc ucaccgugga ggaccacuac uacgaaggug gcauaggaga 1800ggcagugucu gcugccguag ugggugaacc uggagugacg gucacucgcc uggcugucag 1860ccaaguacca cgaaguggca agccagcuga gcuacugaag auguucggua uugacaagga 1920cgccauugug caagcuguga aaggccuugu caccaagggc uagggagggc augggaugcu 1980ggguggguga acuacacauu ccagggaggu ucuggcagag guggcgaagg uguacugagu 2040ggggagguaa auauauguuu

ug 206223230RNAHomo sapiens 23uuaacggugu cauaaauaag uaauauaacu uuauuaaaau gaaaagacaa uauucaaaau 60aaugcaacaa aaugaauaaa uccuuugucc aauacuguac acacagugcg gagaucagug 120cauuuuucua aagcauguuu uaaccuucau uuaguucaua cuaaaguaag cuuuaaauag 180cucaaauaau gucauucagc aguuuaaacu gaacagcuug uugggacaug 230241560RNAHomo sapiens 24ugaguucucg uaaacuccag agcagcgaua ggccguaaua ucggggaaag cacuauaggg 60acaugauguu ccacacguca caugggucgu ccuauccgag ccagucgugc caaaggggcg 120gucccgcugu gcacacuggc gcuccaggga gcucugcacu ccgcccgaaa agugcgcucg 180gcucugccag gacgcggggc gcgugacuau gcgugggcug gagcaaccgc cugcugggug 240caaacccuuu gcgcccggac ucguccaacg acuauaaaga gggcaggcug uccucuaagc 300gucaccacga cuucaacguc cugaguaccu ucuccucacu uacuccguag cuccagcuuc 360accagaucuc ggaauggacc ccaacugcuc cugcuccacc gguaagacuc ccgauccuug 420gucuuuagaa uaccaaguug ggaccgcaga gcggaauccc cgaguuguag aggcuuggcg 480ggaauaggca ccuuuaguug gcgauucauu ccgguucuuu cuagaauccg cucuugcaaa 540agccuucauu aguuacgagu auugucgaac ggguccuuug gcgggguugg 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guuuuggacc cccucgugcc uuuaccuccg cccucuggcc cucacagagg 1500gguaaugucu uuggguaaag ccaagcuaua ucccauaagc uuccucaugg aaaacagcug 156025253RNAHomo sapiens 25gcggcacgau gugucuucgg guggcuuuuu uuuuuuuguu uugaauaaug uuuacaauuu 60cccucaauca cuuuuauaga aauccaccuc caggcccccc ccuuucccca cuuaggccuu 120cgaggcuguc ugaagaugcu ugagaaacuc aaccaaaucc caguucaauu cagacuuugc 180acauauauuu auauuuauaa ucagaaaaga aacauuucag uaauuuauaa uaaaagagca 240cuauuuuuua acg 253263660RNAHomo sapiens 26uugcaggcga gggcuuccac aacuaccacc acaccuuccc cuucgacuac ucugccagug 60aguaccgcug gcacaucaac uucaccacgu ucuucaucga cugcauggcu gcccugggcc 120uggcuuacga ccggaagaaa guuucuaagg cuacugucuu agccaggauu aagagaacug 180gagacgggag ucacaagagu agcugagcuu ugggcuucug aguuccuguu ucaaacguuu 240ucuggcagag auuuaauauu cuguugauua acuaacaacu ggauauugcu aucggggugu 300uaaugaugca uuuaaccuau uccgguacag uauucuuaua aaaugagaaa gcuuugauca 360cguuuugagg uaauaaauau uuuauuuagc uaggauuaac caugccacaa gacauuauau 420auuucuaagc acacaugaua aaugcauaua caauuuugca 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agaccugaua ccuaacacuc ugucacacag uccagggcca acagugcuau 2220aggaaagucu agaagaaaac aucacaucag uauuuuagaa ccaucaacca ucucuugucc 2280cuauagccca auccagaggc cugguuuuua gaacuggcug uguaaggugc caaacacuca 2340guucacuugu agaaucagag ccuuuuuucc ccccuauguu aauugaacac gcgcucugag 2400cuguuuuguu gaaguagaaa aucucauaga aaaaucacug uagaucuacu gaccuauagc 2460ccucuggaaa ugccuuugag augguuuuac uuuucuaggu cauagaugcc ugauuauaaa 2520gaugaacaau aaaaucagcu uucuuucuuu cucuucugau cuuauucccc agaucugauu 2580caggccaugu uccaaagcaa ggcuacauug agguccuggu gucuuuaagu aaaggacauc 2640uuucagaucc ucucaaagaa ggauuuauaa caguuuccag augaauguac uaauagcuuu 2700gggugccuua ucucuuuccu aaucuguagu gccugugagc ucagucucac uccuucccuu 2760agcccggaga ccccuuagau cgagugggaa uagucaagag gcuggcugga gagucaucag 2820uacauugguu ugcagaaauc uuuuacaggc uacauuuugg aauuuuuuuu uuuuuaguaa 2880gugaucaaau uuggugggaa guaauucgag uguauucgau uguauugucg uccucguuau 2940cauugucaaa cauguuauag acggcaguug gcacuggggc ugcuaaucuc uggguguagu 3000cucugaaacu guagcuccag ugagguggug ugaaagguua gcaaagccac caucugcugg 3060ugcuccagcc aaggugccuc uuagccacug aauugcuaug uuauccuuuc ucuuguaaca 3120aacccacccc agagauaaag ccuuuaauca acccaagaaa cuccugggcu aaguaucuga 3180cagucucaca ucucaacagu gugaauuaag uguccauagc aucagcucag gaggacacuc 3240ugggagagug cugacaaaaa aggguuauua auacugaccu acuacuucaa gggcaguucu 3300gaggugauua gagcuuuuuu uaaaaaccaa guauuugggg auccucagca gagguauuca 3360uacagacucc caaagaacua uauauguucc ugagaccauc guuuagucua cauugcucuu 3420cccagagacu gacagauaug accagucaaa gugcaagacu accuacccac ugccaugaaa 3480accauugcag gaaaccuuuc ccuuccugaa ugagauuuuu uuuuucccuu uuuauguggg 3540guaauuauuu gugacccaag uguaauuugg augauuucca uuaauaucaa cucuugaagc 3600cuacuuguac ugauugagau uguauuuguu ccuaauaaaa guggaucugg uuguacuguc 3660271969RNAHomo sapiens 27acugccaucg agugguguuc caguugaacu ugcucucucu gccaucugcu ccgcgggcgc 60cgucagcaug ggucccugga cccacuccuu gcgcgccguc cugcugcugg ugcuuuuggg 120agucugcacc gugcgcuccg acacuccugc caacugcacc uacccugauc ugcugggcac 180cuggguguuc caggugggcc cuagaaguuc ccgaagcgac auuaacugcu cggugaugga 240agcaacagaa gaaaagguag ugguacaccu uaagaaguug gauacugccu acgacgagcu 300gggcaauucc gggcauuuua cccucauuua caaccaaggc uucgagauug uguugaauga 360cuacaaaugg uuugcguuuu ucaaguauga agucagaggc cacacagcua ucaguuacug 420ccaugagacc augacugggu ggguccauga ugugcugggc cggaacuggg cuugcuuugu 480uggcaagaag guggaaaguc acauugagaa gguuaauaug aaugcagcac aucuuggagg 540ucuccaggaa agauauucug aaagacucua cacucacaac cacaacuuug ugaaggccau 600caauaccguu cagaagucuu ggacugcaac ugcauauaag gaauaugaga aaaugagccu 660gcgagaucug auaaggagaa guggccacag ccaaaggauc ccaaggccca aaccugcccc 720gaugacugau gaaauacagc aacaaauuuu aaauuugcca gaaucuuggg acuggagaaa 780cguccaaggc gucaauuaug uuagcccugu ucgaaaccaa gaaucuugug gaagcugcua 840cucauuugcc ucuaugggua ugcuagaagc aagaauucgu auauuaacca acaauucuca 900gacaccaauc cugaguccuc aggagguugu aucuugcagc cccuaugccc aagguuguga 960ugguggauuc ccauaccuca uugcagggaa guaugcccaa gauuuugggg ugguggaaga 1020aagcugcuuu cccuacacag ccaaagauuc uccaugcaaa ccaagggaga auugccuccg 1080uuacuauucu ucugacuacu acuauguggg ugguuucuau gguggcugca augaagcccu 1140gaugaagcuu gagcugguca aacauggacc cauggcaguu gccuuugaag uccacgauga 1200cuuccuacac uaccacagug gaaucuauca ccacacuggg cugagugacc cuuucaaccc 1260cuucgagcug acaaaucaug cuguuuugcu ugugggcuau ggaagagauc caguuacugg 1320gauagaauac uggauuauaa agaacagcug gggcucuaac uggggggaga guggcuacuu 1380ccguauccgc agaggaacug augaaugugc aauugagagu auagccgugg cggccauacc 1440gauuccuaaa uuauaggaca uagcucccag uguuacauac gggucuuuau cacucacaga 1500gugauuuagu cacaugcuga agacuuuuuc agagcaauau cagaagcuua ccacuaagca 1560ucuuuaaaga auuuugucuu ugaacuuaaa accauccuug auuuuuuucu uuuaauaucu 1620uccccaucaa cuacugaacu acuuuucuuu uuaaaguacu ugguuaagua auacuuuuau 1680gagcaguggu ucaguugucc aauauuuuuu gcaggucauc uacaaugcaa ccagauguuu 1740caguucuaaa aaucuaugua aaaguacaag cucguuuuua aauuauguaa gucacaugaa 1800aacauggcaa aaaaauuagu uaaauuuuuu acaaagaguu uuaaauaaau guuuauguaa 1860ucaguaccau agucuuucua uguguguuua caagaauuuu ugucaccuac uucuucccuu 1920agaagcauuu augcuccaug gacguacuuc uuuauggaga aaaaaaaaa 1969281478RNAHomo sapiens 28gagcucgauc ccuguuccgc cuuugcuaug ucugaaggcg uccugcuuug cgcgugucgg 60ggccaaaucc agauuuucau uucgcuccag gcuuggacgg cuaaguaggu ccaaaccgca 120caaacaggaa ggagggaagg caaggagugc gggcagaggg cgggucguuc ccagcagcac 180cccagucccu ccccgcuccg ucuccgaccc acuggggccg gggcgggcgu gcgcgucagc 240uggggcuaga aaaggcggcg guccggcccg gcgaggugac agccaacuug gacgccaggu 300ccggccgacg ccgccaugag cgccgcgcuu uucagccugg acagcccggu gcgcggcaca 360cccuggccca cagaacccgc ggccuucuac gagccaggca ggguggacaa gcccggccga 420gggcccgagc caggggaacu gggggagcug ggcuccacga cuccugccau guacgacgac 480gagagcgcca ucgacuucag cgccuacauu gacuccaugg ccgccgugcc cacccuagag 540cugugccacg acgaacucuu cgccgaccuc uucaacagca accacaaagc ggccggcgcg 600ggcggccugg agcugcugca gggcggcccu acgcgacccc cggguguggg gucugucgcu 660agggggccgc ucaagcgcga acccgacugg ggcgacggcg acgcgccggg cucccugcug 720ccggcgcaag uggcggugug cgcgcagaca guggugagcu uggcggccgc ggcucagccc 780acuccaccca cuucgccgga gccuccucga ggcagcccgg ggccgagccu cgcgcccggc 840acaguccgag aaaagggcgc gggcaagagg gguccggacc gcggcagccc ggaguaccgg 900cagcggcgcg agcgcaacaa caucgcugug cgcaagagcc gcgacaaggc caagcgccgc 960aaccaggaga ugcagcagaa gcugguggag uugucggccg agaacgagaa gcugcaucag 1020cgcguggagc agcucacccg ggaccuggcu ggccuccggc aguucuucaa aaaacugccc 1080agcccgccuu uccugccgcc caccggcgcc gacugccggu aacgcgcggc gugggccuuu 1140gagacucuga acgaccuaua ccucagaccc cgacagcggg gagcagacgc cgcccgaauc 1200gcuaguuucu uugggaccug cgagcgacag gaagcugcag cuugggcacu ggacugcgag 1260agaagcuaua uuaaucuuuc cccuuaaauu auuuuuuaua augguagcau uuucuacguc 1320uuauuaccau ugcagcuaag guacauuugu agaaaagaca uuuccgacag acuuuuguag 1380auaagaggaa gagacugcgc augcuuuuua uauucauuuu uacaguauuu guaagaauaa 1440gaauaagaau aaagaagcau uuaaaucgca aaaaaaaa 1478291786RNAHomo sapiens 29uugagggugg ccaggccagc guaggaggcc agcguaggau ccugcuggga gcggggaacu 60gagggaagcg acgccgagaa agcaggcgua ccacggaggg agagaaaagc uccggaagcc 120cagcagcgcc uuuacgcaca gcugccaacu ggccgcugcc gaccgucucc agcucccgag 180gacgcgcgac cggacaccgg guccugccac agccgaggac agcucgccgc ucgccgcagc 240gagcccgggg cggcccuuca gggggaccuu ucccagaucg cccaggccgc ccggaugugc 300acgaaaaugg aacagccuuu cuaucacgac gacucuuacg cagcggcggg auacggucgg 360agcccuggca gccugucucu acacgacuac aaacuccuga aacccaccuu ggcgcucaac 420cuggcggauc ccuaucgggg ucucaagggu ccuggggcgc gggguccagg cccggagggc 480aguggggcag gcagcuacuu uucgggucag ggaucagaca caggcgcauc ucugaagcua 540gccuccacgg aacuggagcg cuugaucguc cccaacagca acggcgugau cacgacgacg 600cccacgccuc cgggacagua cuuuuacccc cgugggggug gcagcggugg agguacaggg 660ggcggcguca ccgaggagca ggagggcuuu gcggacgguu uugucaaagc ccuggacgac 720cugcacaaga ugaaccacgu gacgcccccc aacguguccc ugggcgccag cggggguccc 780caggccggcc cagggggcgu cuaugcuggu ccggagccgc cucccgucua caccaaccuc 840agcaguuacu cuccagccuc ugcacccucu ggaggcuccg ggaccgccgu gcggacuggg 900agcucauacc cgacggccac caucagcuac cucccacaug caccacccuu ugcgggcggc 960cacccggcac agcuggguuu gagucguggc gcuuccgccu uuaaagagga accgcagacc 1020guaccggagg cacgcagccg cgacgccacg ccgccugugu cccccaucaa cauggaagac 1080caggagcgca ucaaagugga gcgaaagcgg cugcggaaca ggcuggcggc caccaagugc 1140cggaagcgga agcuggagcg caucgcgcgc cuggaggaca aggugaagac acucaaggcu 1200gagaacgcgg ggcugucgag ugcugccggu cuccuaaggg agcaaguggc gcagcucaag 1260cagaagguca ugacccaugu cagcaacggc ugccaguugc ugcuaggggu caagggacac 1320gccuucugag agccucccuu gccccauacg gacaccccca gccuugaagg cugggcgccu 1380gccccccacu ggggugaggg gggcaggcga ugggcacccg ccaaaaggcc uggggcgcag 1440cucacacacu ggacuccggc ccgcccgccu gcgcccaguc cuuccaccuc gagguuuaca 1500uggcccccuu ccagcguauu uuguauguuu uuuuuuucug caaagagacu gaauucauau 1560ugaauauaau auauuugugu auuuaacagg agggagaagg gggcugucgc ggcggagcug 1620gccgccgcuu gguacucagc ugcggggaua cuagggaggg accuccgccc ccugcccucc 1680cccucugcau aguacugugg agaagaaaca cgacuucgug ucuaaagucu auuuuaagau 1740guguuugugu guguguguuu gacuuuuuau ugaaucuauu uaagua 1786301897RNAHomo sapiens 30gaauucggca cgagcagcga gacgccgcgc acggugcuuc cccaguggag ccaaucggcu 60aacccgcgcu ccggcagagu ccuuggcgcu cgcccgccgg cgggacagac cacccgccuc 120uggccgcucu cuggacccug gccgccccga gcgaagacug gagcaaaaug augcuucaac 180auccaggcca ggucucugcc ucagaaguca gugcgaccgc cauugucccc ugccucucac 240cuccuggguc acugguauuu gaggauuuug cuaaccugac acccuuuguc aaggaagagc 300ugagauucgc cauccagaau aaacaccucu gccaucggau guccucugcg cuggagucag 360uuaccgucaa caacagaccc cuggagaugu cagucaccaa gucugaggcg gccccugaag 420aagaugagag gaaaaggagg cggcgagaaa gaaauaaaau ugcugcugcc aagugucgaa 480acaagaaaaa ggagaagaca gagugccugc agaaagaguc agagaaacug gagaguguga 540augcugagcu gaaggcccag auugaggagc ugaagaauga gaaacagcau uugauauaca 600ugcucaaccu gcaccggccc accuguaucg uccgggcuca gaauggacgg acaccggaag 660acgagaggaa ccucuuuauc caacagauaa aagaaggaac auugcagagc uaagcagagg 720uggcacggag gcaauugggg aguucuuacu gaauccuccu uuuccacccc acacccugaa 780gccauuggaa aacuggcuuc cugugcacuu cuagaauccc agcagccaag agccguuggg 840gcaggagggc cuguggugac cuacugcauu gacccacucu gcccccgagu gaaccgugga 900gcaggcagga gcauccuuug ucucaccaau uccaggauuu aggccuuauc aucccggcca 960gucucagaug accuagcugg ccccaggcug ggguccuaug caaagcagga ucccacuaau 1020gggauucagg cagaaguguc uaccuugaua gguggggugg gaccacaucc uccacugugg 1080cugacaacgc ccuuccaagg gaauauggaa ugagaacauu cauuauugag guuguccaau 1140ggccagggua ugcuuucuag aaaauaugcu guucuguccc agaaugacug ugcauagggu 1200auccguuuca gagccuggug uugugcuauu uagauguuug ucuugcacaa cauuggcaug 1260auuuuuccgg gaguuucauc agaucugauu ucugagaguc uggggaucug ccauggugga 1320aagugccccu caaaagcauu uguguggcca caugaacugg cuggcaccag gggagugaaa 1380cuggcugaug accagcugag ccacuuugug ccaacagagg auggacgaca ccuuucccug 1440uacccacugc agaggaagaa cccugggcac agcagcuuug uccuuggcua caaacuguua 1500caacgucaca caaugaaggc acaaagucca acuuucaaag gguguaggac uccauacuca 1560gugacagggc aggaagagcc aaagauaacc acagccacag ccuguggaga ccaggguugg 1620aagccaggug cagggccagg caucugcauu gugggauguu aauggcacuu uugucuugua 1680gcuauuuuga gauguggucc agagcauuuc agcugggaga ucucccucug gccaccagga 1740cucuggcuac uguuaaaauc cugauguuuc uguggaaucc ucaguguuua aucccacuca 1800auaguaucau uacaguuuuc uguaagagaa aauauuacuu auuuauccca guauuccuag 1860ccugucaaca uaauaaauau cggaacaaaa ccuggua 189731473RNAHomo sapiens 31uuuuuuuuuu uuuuuuugcu gauaagaauu cuuuuuaugu uauucgaaua aaaaauacau 60ucauacagaa auauaacaau cucgcaaaaa acaauuucaa auaaaaucuu guaaaacaaa 120auuuuacaaa aaucuuacaa agauucuuua gauaacaggg ugcuucaaaa aaaaagaaau 180aaagaaauuu cacuaauaga aauuuuuuuu uuuaauuuca agcaaaaguu ccugcuugau 240ugaggcucag uugucaccug accagaaugg acugcuuagu auuaaaguua cagcaucgac 300acggacggca cccagcccca gccaguccag caacgucgcu guguuucaua agugagacgc 360gccagcacaa guuuccucuc ucuucuguuu accuucuuac uuaauggaau ugcuauggau 420aagcacacag cagggccaaa aaaggaguuu uccaaaaucc agcaaaucaa gug 473321680RNAHomo sapiens 32uaguggugau cuggaccgug cggacuugcu cgucccucag cucuccuguu aggcgucucu 60uuucuccagg aggaaaaaau ggcagcagca guaguggauc cgcaacagag cguggugaug 120agaguggcca accugcccuu ggugagcucu accuacgacc uuguguccuc cgcuuauguc 180aguacaaagg aucaguaccc guauuugaga uccgugugug agauggccga gaagggcgug 240aagaccguga ccucugcggc caugacaagu gcccugccca ucauccagaa gcuggagcca 300caaauugcgg uugccaauac cuaugccugc aaggggcuag acaggaugga ggaaagacug 360ccuauucuga accagccaac guccgagauu guugccagug ccagaggugc cguaacuggg 420gcgaaggaug uggugacgac uaccauggcu ggagccaagg auucuguagc cagcacaguc 480ucaggggugg uggauaagac caaaggagca gugacuggca gcguggaaag gaccaagucu 540guggucaaug gcagcaucaa uacaguuuug gggauggugc aguucaugaa caguggagua 600gauaaugcca ucaccaaguc ggagaugcug guagaccagu acuucccucu cacucaggag 660gagcuggaga uggaagcaaa aaagguggaa ggauuugaua ugguucagaa gccgagcaac 720uaugaacggc uggagucccu gucuaccaag cucugcucuc gggcuuauca ccaggcucuc 780agcaggguua aagaggccaa acaaaagagc caggagacca uuucucagcu ccacuccacu 840guccaccuga uugaauucgc caggaagaau augcacagug ccaaccagaa aauucagggu 900gcucaggaua agcucuaugu cucgugggug gaguggaaga gaagcaucgg cuacgacgac 960accgaugagu cccacugugu ugagcacauc gagucacgua cucuggcuau cgcccgcaac 1020cugacccagc agcuccagac uacaugccag acuguccugg ucaacgccca aggguuacca 1080cagaacauuc aagaucaggc caaacacuug ggggugaugg caggcgacau cuacuccgua 1140uuccgcaaug cugccuccuu uaaggaagug uccgauggcg uccucacauc uagcaagggg 1200cagcugcaga aaaugaagga auccuuagau gaaguuaugg auuacuuugu uaacaacacg 1260ccucucaacu ggcugguagg ucccuuuuau ccucagucua ccgaggugaa caaggccagc 1320cugaaggucc agcagucuga ggucaaagcu caguaaaccc cuccuuguca ccagagcaug

1380auguugcugg ccagaugacc ccuuuugcug uauugaaauu aacuugguag auggcuuuag 1440cuuagaaaag cagcuucuua gaaccaaggg ccucauuaug gucacucaca gcucaguuau 1500ggucuugccc cagcuggccc uggcacagga guucucuuac cuggcuggug aguggccugu 1560guuagucuug ugaggaccug gaggaaccua aaagcucaga ugcacuuaca gucuugucug 1620uggccuuugu auuguuauug gcuguaaacg ucugucugga ccgaauaaag auucacguga 1680331783RNAHomo sapiens 33ggcacgaggg agcugcagug uucgcgcuug guagcuggug caucggacuc agcuggcuuu 60gugucccuga ggcucaccga aaaacacuuu cucagcccuc ugacuccaga gagagagaga 120gagagguacu uuuugugguc accgacuuug accccugcag aggcugagcg auggcgucua 180ugggacuaca gguccuggga aucuccuugg caguccuggg cuggcugggg aucauccuga 240guugugcgcu ccccaugugg cgggugaccg ccuucaucgg cagcaacauc gucacggcac 300agaccagcug ggagggccuc uggaugaacu gcguggugca gagcacaggu cagaugcagu 360gcaagaugua cgacucgaug cucgcccugc cgcaggaccu gcaggccgcc cgagcccuua 420uggucaucag caucaucgug ggugcucugg ggaugcuucu cucaguggua gggggcaagu 480gcaccaacug cauggaggac gagaccguca aggccaagau caugaucacc gccggagccg 540uguucaucgu ggcaagcaug cugauuaugg ugcccguguc cuggaccgcu cacaacguca 600uccgcgacuu cuacaacccu augguggcuu ccgggcagaa gagggaaaug ggggccucgc 660uuuacgucgg cugggcggcc uccgggcugc ugcuccuggg aggaggccuc cucugcugca 720guugcccacc ucguagcaac gacaagcccu acucggccaa guacuccgcc gcccgcucug 780uccccgccag caacuaugug uaaggugggc cacucugucc acauugccuu uguuauuuuu 840uuucggauug agcucauaac agccuguggc cccucacauu cuccaggacc ugcccugcua 900ugggccacua acugcuugcu ggggacaggc aaacccggac ugugcaaagu uacuagcccg 960uagcucuugg gcugcuccac auggcuccuu acggccggca agaauggaug uaaaaauauc 1020uugcugcuua cauccaaauu gcgguggaua ugggcugaag gcagaagcag cugggaaggg 1080caguagaggc gcaagcuggg uccugcuggc cgggguagcu cagcugugac uuuggacucg 1140gaguggaugu ccucauguua gcaaacgucc acuguccuuu cucuaucccc cucacucagc 1200cuacacguua cuccagcgcu acucuugcca uuacgccccg uguuuccgag cacagcuggu 1260ccuaccccaa gucauggugu gcugagugac ugaugagggg ccauugagag ccggugggcu 1320cugccaugga acccuuccgu ugauuagcaa ugacugugcu ugacccaccc accuacccua 1380cuaaugaauu ucuguagagu ggauggacgg guuugaggga agaagggugg agguggauua 1440aacugguuug gggagggcug gggaccuaga agcagcccag ugugucccca ccccuuuucc 1500gcacugucuu gcuaauguuc ugaucacugu gcgcccccuc ccucuucaga aggacccugg 1560gccucuugag uuggccccuc ugaguucccu cccuuugccc auuucaagga caccggccag 1620ucugcggaag gaagguacgg gggggggggg ggggggugau ggcauuguac cagggagucu 1680ccuggacucc ccugccuucu cugugguuuc uuguuuugua auuaaggucu guucacagcu 1740guaauuauua uuauuuucua caauaaaugg caccugcaua cag 1783341786RNAHomo sapiens 34uugagggugg ccaggccagc guaggaggcc agcguaggau ccugcuggga gcggggaacu 60gagggaagcg acgccgagaa agcaggcgua ccacggaggg agagaaaagc uccggaagcc 120cagcagcgcc uuuacgcaca gcugccaacu ggccgcugcc gaccgucucc agcucccgag 180gacgcgcgac cggacaccgg guccugccac agccgaggac agcucgccgc ucgccgcagc 240gagcccgggg cggcccuuca gggggaccuu ucccagaucg cccaggccgc ccggaugugc 300acgaaaaugg aacagccuuu cuaucacgac gacucuuacg cagcggcggg auacggucgg 360agcccuggca gccugucucu acacgacuac aaacuccuga aacccaccuu ggcgcucaac 420cuggcggauc ccuaucgggg ucucaagggu ccuggggcgc gggguccagg cccggagggc 480aguggggcag gcagcuacuu uucgggucag ggaucagaca caggcgcauc ucugaagcua 540gccuccacgg aacuggagcg cuugaucguc cccaacagca acggcgugau cacgacgacg 600cccacgccuc cgggacagua cuuuuacccc cgugggggug gcagcggugg agguacaggg 660ggcggcguca ccgaggagca ggagggcuuu gcggacgguu uugucaaagc ccuggacgac 720cugcacaaga ugaaccacgu gacgcccccc aacguguccc ugggcgccag cggggguccc 780caggccggcc cagggggcgu cuaugcuggu ccggagccgc cucccgucua caccaaccuc 840agcaguuacu cuccagccuc ugcacccucu ggaggcuccg ggaccgccgu gcggacuggg 900agcucauacc cgacggccac caucagcuac cucccacaug caccacccuu ugcgggcggc 960cacccggcac agcuggguuu gagucguggc gcuuccgccu uuaaagagga accgcagacc 1020guaccggagg cacgcagccg cgacgccacg ccgccugugu cccccaucaa cauggaagac 1080caggagcgca ucaaagugga gcgaaagcgg cugcggaaca ggcuggcggc caccaagugc 1140cggaagcgga agcuggagcg caucgcgcgc cuggaggaca aggugaagac acucaaggcu 1200gagaacgcgg ggcugucgag ugcugccggu cuccuaaggg agcaaguggc gcagcucaag 1260cagaagguca ugacccaugu cagcaacggc ugccaguugc ugcuaggggu caagggacac 1320gccuucugag agccucccuu gccccauacg gacaccccca gccuugaagg cugggcgccu 1380gccccccacu ggggugaggg gggcaggcga ugggcacccg ccaaaaggcc uggggcgcag 1440cucacacacu ggacuccggc ccgcccgccu gcgcccaguc cuuccaccuc gagguuuaca 1500uggcccccuu ccagcguauu uuguauguuu uuuuuuucug caaagagacu gaauucauau 1560ugaauauaau auauuugugu auuuaacagg agggagaagg gggcugucgc ggcggagcug 1620gccgccgcuu gguacucagc ugcggggaua cuagggaggg accuccgccc ccugcccucc 1680cccucugcau aguacugugg agaagaaaca cgacuucgug ucuaaagucu auuuuaagau 1740guguuugugu guguguguuu gacuuuuuau ugaaucuauu uaagua 1786351389RNAHomo sapiens 35augcagcuga gaaaaaugca gaccaucaaa aaggagcccg caccccuaga uccuaccagc 60agcucagaca agaugcugcu gcugaacucu gccuuagcug agguggccga ggaccuagcc 120ucaggugaag auuugcuccu gaacgaaggg agcaugggga aaaacaaauc cucggcgugu 180cggagaaaac gggaauucau uccggacgag aagaaagacg ccauguauug ggagaaacgg 240cggaaaaaca acgaagcugc caaaagaucu cgggagaagc gccgccucaa ugaccugguu 300uuggagaaca agcugauugc ccugggagaa gaaaaugcca cuuuaaaagc ugagcugcuc 360ucccugaaau uaaaguuugg uuuaauuagc uccacggcgu augcccaaga aauccagaaa 420cucaguaauu ccacagcugu cuacuuucag gacuaccaga cauccaaggc ugccgugagc 480ucuuuugugg acgagcauga gccugcgaug guagccggaa guugcaucuc agucaucaag 540cacucucccc agagcucgcu cuccgaugug ucagaggugu ccucggugga gcacacucag 600gaaagccccg cacagggagg cugccggagc ccugagaaca aguucccugu gaucaagcag 660gagcccgugg aguuggagag cuuugccagg gaggccaggg aggagcgggg cacguauucc 720accuccaucu accagagcua caugggaagc ucuuucucca cuuacuccca cuccccaccc 780cucuugcagg uccauggguc cacuagcaac uccccaagaa ccucagaggc cgaugagggu 840guagugggca agucuucuga uggggaagac gaacaacagg ucccuaaggg ccccauccau 900ucuccagugg agcugcaacg gguucacgcc acggugguga agguuccgga agugaacccu 960ucugccuuac cgcacaagcu ucggauuaaa gccaaggcca ugcaggucaa aguggaggcu 1020uuggacagcg aguuugaagg caugcagaaa cucucuucac ccgccgaugc gaucgccaaa 1080agacauuuug accuggagaa acauggaacc ucggguaugg cccauuccuc ccucccuccu 1140uucucagugc aggugacgaa cauucaagau uggucccuca aaucggaaca cuggcaucac 1200aaagaacuga gcagcaaaac ucagaguagc uucaaaacag guguggugga agucaaagac 1260gguggcuaua agguuuccga agcugagaau uuguauuuga agcagggaau agcaaacuua 1320ucugcagagg uggucucgcu caagagauuc auagccacac aaccgaucuc ggcuucggac 1380uccagguaa 138936961RNAHomo sapiens 36gcucccggga aacgaaugag gaaccaccuc cuccugcugu ucaaguacag gggccuggug 60cgcaaaggga agaaaagcaa aagacgaaaa uggcuaaauu uaagauccgu ccagccacug 120ccucugacug cagugacauc cugcgacuga ucaaggaacu ggcuaaauau gaauacaugg 180aagaucaagu cauuuuaacu gagaaagauc uccaagagga uggcuuugga gaacaccccu 240ucuaccacug ccugguugca gaagugccua aagagcacug gaccccugaa ggacauagca 300uuguuggguu cgccauguac uauuuuaccu augacccaug gauuggcaag uugcuguauc 360uugaagacuu cuucgugaug agugauuaca gaggcuuugg uauaggauca gaaauuuuga 420agaaucuaag ccagguugcc augaaguguc gcugcagcag uaugcacuuc uugguagcag 480aauggaauga accaucuauc aacuucuaca aaagaagagg ugcuucggau cuguccagug 540aagagggaug gaggcucuuc aagauugaca aagaguacuu gcuaaaaaug gcagcagagg 600agugaggcgu gccgguguag acaaugacaa ccuccauugu gcuuuagaau aauucucagc 660uucccuugcu uucuaucuug uguguaguga aauaauagag cgagcaccca uuccaaagcu 720uuauuaccag ugacguuguu gcauguuuga aauucggucu guuuaaagug gcagucaugu 780augugguuug gaggcagaau ucuugaacau cuuuugauga agaacaaggu gguaugaucu 840uacuauauaa gaaaaacaaa acuucauucu ugugagucau uuaaaugugu acaauguaca 900cacugguacu uagaguuucu guuuugauuc uuuuuuuuua aauaaacucg cucuuugauu 960u 961372187RNAHomo sapiens 37cgcuggcucc gugcgccaug gucacccaca gcaaguuucc cgccgccggg augagccgcc 60cccuggacac cagccugcgc cucaagaccu ucagcuccaa aagcgaguac cagcuggugg 120ugaacgccgu gcgcaagcug caggagagcg gauucuacug gagcgccgug accggcggcg 180aggcgaaccu gcugcucagc gccgagcccg cgggcaccuu ucuuauccgc gacagcucgg 240accagcgcca cuucuucacg uugagcguca agacccaguc ggggaccaag aaccuacgca 300uccaguguga ggggggcagc uuuucgcugc agagugaccc ccgaagcacg cagccaguuc 360cccgcuucga cuguguacuc aagcuggugc accacuacau gccgccucca gggacccccu 420ccuuuucuuu gccacccacg gaacccucgu ccgaaguucc ggagcagcca ccugcccagg 480cacuccccgg gaguaccccc aagagagcuu acuacaucua uucugggggc gagaagauuc 540cgcugguacu gagccgaccu cucuccucca acguggccac ccuccagcau cuuugucgga 600agacugucaa cggccaccug gacuccuaug agaaagugac ccagcugccu ggacccauuc 660gggaguuccu ggaucaguau gaugcuccac uuuaaggagc aaaaggguca gaggggggcc 720ugggucgguc ggucgccucu ccuccgaggc acauggcaca agcacaaaaa uccagcccca 780acggucggua gcucccagug agccaggggc agauuggcuu cuuccucagg cccuccacuc 840ccgcagagua gagcuggcag gaccuggaau ucgucugagg ggagggggag cugccaccug 900cuuucccccc ucccccagcu ccagcuucuu ucaaguggag ccagccggcc uggccuggug 960ggacaauacc uuugacaagc ggacucuccc cuccccuucc uccacacccc cucugcuucc 1020caagggaggu ggggacaccu ccaaguguug aacuuagaac ugcaagggga aucuucaaac 1080uuucccgcug gaacuuguuu gcgcuuugau uugguuugau caagagcagg caccuggggg 1140aaggauggaa gagaaaaggg ugugugaagg guuuuuaugc uggccaaaga aauaaccacu 1200cccacugccc aaccuaggug aggaguggug gcuccuggcu cuggggagag uggcaagggg 1260ugaccugaag agagcuauac uggugccagg cuccucucca uggggcagcu aaugaaaccu 1320cgcagauccc uugcacccca gaacccuccc cguugugaag aggcaguagc auuuagaagg 1380gagacagaug aggcugguga gcuggccgcc uuuuccaaca ccgaagggag gcagaucaac 1440agaugagcca ucuuggagcc cagguuuccc cuggagcaga uggaggguuc ugcuuugucu 1500cuccuaugug gggcuaggag acucgccuua aaugcccucu gucccaggga uggggauugg 1560cacacaagga gccaaacaca gccaauaggc agagaguuga gggauucacc cagguggcua 1620caggccaggg gaaguggcug caggggagag acccagucac uccaggagac uccugaguua 1680acacugggaa gacauuggcc aguccuaguc aucucucggu caguaggucc gagagcuucc 1740aggcccugca cagcccuccu uucucaccug gggggaggca ggaggugaug gagaagccuu 1800cccaugccgc ucacaggggc cucacgggaa ugcagcagcc augcaauuac cuggaacugg 1860uccuguguug gggagaaaca aguuuucuga agucagguau ggggcugggu ggggcagcug 1920uguguugggg uggcuuuuuu cucucuguuu ugaauaaugu uuacaauuug ccucaaucac 1980uuuuauaaaa auccaccucc agcccgcccc ucuccccacu caggccuucg aggcugucug 2040aagaugcuug aaaaacucaa ccaaauccca guucaacuca gacuuugcac auauauuuau 2100auuuauacuc agaaaagaaa cauuucagua auuuauaaua aaagagcacu auuuuuuaau 2160gaaaaaaaaa aaaaaaaaaa aaaaaaa 2187382046RNAHomo sapiens 38aaggaaucuu caguacagaa acaagaccca aguguaaguu uaacuggcag gaggaaccaa 60ccaaggacag uuaaggagaa aacccaaccc uuagaagaac ucaccaguuu ccaagaggaa 120acugccaaaa gaauaucuuc caaaucucca caaccggaag agaaggaaac cuuagcaggu 180uuaaagaggc agcucagaau acaacuaauc aacgauggug uaaaagaaga gcccacagca 240cagagaaagc aaccauccag ggaaaccagg aacacacuca aagagccugu aggugacagu 300auaaauguug aagagguuaa gaagucuaca aagcagaaaa uugauccagu agcaagugug 360ccugucagca agaggccacg gaggguaccc aaggaaaagg cacaggcccu agaauuggcu 420ggucucaaag gaccaaucca aacccuaggc cacacugaug aaucagcaag ugauaaagga 480cccacacaga ugcccuguaa uucucuacaa ccagagcaag uugacagcuu ccaaagcuca 540ccaaggcgac ccaggacaag acgugggaaa guagaggcag augaagagcc uucagcagua 600agaaagacag uaucaacauc aaggcaaacu augcgauccc gcaagguccc ugaaauuggu 660aacaauggua cccaaguuuc aaaggccucc auaaagcaga cauuagauac aguagccaaa 720guaacuggca gcaggaggca gcuaaggaca cauaaaggau gggguucaac ccucuugaag 780uuguuaggug acuccaaaga aauaacccaa auaucagauc acucugagaa acuagcacau 840gacaccagua uccuuaagag cacucaacag caaaagccag acucaguaaa accucugaga 900acaugcagaa gagugcugag ggccucuaaa gaggucccca aggaaguguu gguggacacc 960agagaccaug caacauuaca aagcaaaagc aacccuuugc uguccccgaa gaggaagucu 1020gcaagagaug gaagcauugu gagaaccagg gcuuugcgcu cuuuagcacc aaagcaggaa 1080gcaacagaug agaagccugu accugagaaa aaaagggcug cuuccagcaa gagguaugua 1140ucaccugagc cugugaagau gaaacaccug aaaaucgugu caaacaaacu ugaaucugug 1200gaagagcagg uuagcacugu uaugaaaaca gaagaaaugg aagccaaaag agaaaauccu 1260gucacuccag aucagaacuc uagguaccga aagaaaacca auguaaaaca gccaaggccc 1320aaguuugaug caucugcaga gaaugucggg auaaagaaaa acgagaagac uaugaagacu 1380gccucccagg agacagagcu gcagaaucca gaugauggag ccaagaaauc uacaucucgg 1440ggccaaguca gugggaaaag aacaugcuug aggucuagag gaacgacuga gaugccccag 1500ccuugugaag cagaagagaa aacaagcaaa ccagcugcag aaaucuugau aaagccucag 1560gaagagaaag gagucucugg agagucugau guuagguguu ugagguccag aaaaacuaga 1620gucgcuuugg acagugaacc uaagccaagg guaacucgug gaaccaagaa agaugcaaaa 1680acucugaagg aggaugaaga cauuguaugc accaagaagu uaagaacaag aaguuaagaa 1740caagaaguua ccagaaaagu gaaacuaugu agcaaagaca uuuaagaagg aaaaguaaau 1800uugacuuagu gauaaguucc agugugguuu ucaccuccag uguaaagaug aacuguaaau 1860acuacugcua cugccugagu uuaaggaagg aagcuuugag cuuuccuggu cauacucucu 1920ucagacgcca auggagguca ugaggaagau caccagggau cucagcgcaa uuacaguuua 1980ggggugagca ggcagaaaug uggcccucug uccuauccaa uaaagcucug aaauucgcug 2040ccaaaa 204639423RNAHomo sapiens 39uuuuuuuuuu uuuuuuuaaa ucaaaaguua ugaugacuuu auuuuaaauc uuaauacacc 60aaaaauauuu uucaauguug ugagauaagc acuugaaaau aagaauucca acacugcugu 120gauuucgcug ugaggcuuga uagugaauuu ucccucugaa uauggguuua gggccuagga 180agcagaaugc cagucauuuu ccaaguagca gugagcuaag cccagcccgg ucaugcucag 240acccacacuu aacugaaaua uucacacuag gaggcggcac caccaggcaa caccuugauc 300aaccaggaga acaaaagucu gaagugccac caagcauugg ggaaaugaua uuguuuagau 360gcuagugagu cagguucuuu caaauguguc cuaacugggu ugcaaacaua guugcauccu 420uau 42340434RNAHomo sapiens 40gucuguaaaa aucuguuuaa uaaauauaca ucuuagaagu accaaaauaa uuaccaacaa 60aauacaacau auacaacauu uacaagaagg cgacacagac cuuaguuggg ggcgacuuuu 120aagcacaugc cacugaacac cuggcucuua caugggagga cacacugggc ucacuuacua 180ggucuauggu gguucaauca aaagcacaau aaauaaaacg ugguccuuuc auuagguucu 240ggaaaaucac cucccccccc cccaaaaaaa aucccacaaa caugaaccuu aagagacauu 300uucuuugaau uucagugauc uguuuccccg gauuucacaa agacaacagc cgaaucaccc 360caguaaaaug ccugggucua ggcgcugugu gguguggugc uaaguauacc cuuucucauu 420uuuuuucuuu uucu 434411000RNAHomo sapiens 41cggccgccag accuucaagg gcuggagugg acgcgcggac cgacucugaa cagacagacg 60aaccgcggcc gcaagguucc cagacaggau cucacccaga ggcaggcagc ggacagugcc 120uuaguggaac cucgcugucc uccaccgccu ggccccggug caggcgucca guggccgccg 180cauccaaagu gaucgcugcc uccccgucuc cgccagcucg ggaccaugaa gcugcugccg 240ucggugaugc ugaagcucuu ucuggccgca guguuguccg cguuggugac cggugagagu 300cuggagcggc uucggagagg ucuggcggca gcaaccagca acccugaccc ucccacugga 360uccacaaacc agcugcuacc cacgggaggu gaucgugcuc agggggucca ggacuuggaa 420gggacagauc ugaaccuuuu caaaguugcu uucuccucca agccacaagg ccuggccacc 480ccaagcaaag aaaggaaugg gaaaaagaag aagaaaggaa agggguuagg gaagaagaga 540gacccaugcc ucaggaaaua caaggacuac ugcauccacg gggagugcag auaccugcag 600gaguuccgua cucccucuug caaaugccuc ccugguuacc acggacacag gugucauggg 660cugacucuac caguggagaa uccccuauac acauaugacc acacuacagu cuuggcugug 720guggcuguag uacugucguc cgucugucuu cuugucaucg ugggacuucu cauguuuagg 780uaccacagga gaggagguua ugacuuggaa agugaagaga aagugaaguu gggcguggcu 840agcucccacu gaggaggacc ugagcuauag gaaccuucag aggcuacuuc ugagacagug 900guucguuaca cguucuacau agaggagaaa uauuucacca gcagccauga aaacgucuuc 960auucauuucc aguugcuacc cugacugggc cuccuguaau 1000421653RNAHomo sapiens 42ucgaccucac ggucuugcca aaaugucgcu uuccaacaag cugacuuugg acaagcugga 60cgugaagggg aagcgggucg ugaugagggu ggacuucaac guuccuauga agaacaacca 120gauaacaaac aaccaaagga ucaaggcugc uguuccaagc aucaaauucu gcuuggacaa 180uggagccaac uccguugucc uuaugagcca ccugggccgg ccugauggug uucccaugcc 240ugacaaguac uccuuagagc caguugcugc ugaacucaaa ucucugcugg gcaaggaugu 300ucuguucuug aaggauugug ugggcccaga agucgagaau gccugugcca acccagcggc 360ugggacuguc auccugcugg aaaaccuccg cuuucaugua gaggaagaag ggaagggaaa 420agaugcuucu gggaacaagg uuaaagcuga gccggccaaa auugaugcuu uccgagccuc 480acuguccaaa cuaggagaug ucuaugucaa ugaugcuuuu gggacugcac accgagccca 540uagcuccaug guggguguga aucugccaca gaaggcuggu ggauuuuuga ugaagaagga 600gcugaacuac uuugccaagg cuuuggagag uccugagcga cccuuccugg cuaucuuggg 660aggcgcuaaa guugcagaca agauccagcu gaucaauaau augcuagaca aagucaauga 720gaugaucauu ggugguggaa uggccuuuac cuuccuuaag guccucaaca acauggagau 780uggcacaucu cuguaugaug aagaaggagc caagauuguc aaagaucuca uguccaaagc 840ugagaaaaau ggugugaaga uuaccuugcc uguugacuuu gucacugcug acaaauuuga 900ugagaaugcc aagacuggcc aagcuacugu ggccucuggu auaccugcug gcuggauggg 960cuuggacugu gguacugaga gcagcaagaa auaugccgag gcuguggguc gagcuaagca 1020gauuguuugg aaugguccug uugggguauu ugaaugggaa gccuuugcca ggggaaccaa 1080gucacucaug gaugaggugg ugaaagccac uucuaggggu ugcaucacua ucauaggugg 1140uggagacacu gccacuugcu gugccaaaug gaacacagag gauaaaguca gccaugugag 1200cacugggggc ggugccaguc uagagcuccu ggaagguaaa guccuuccug ggguggaugc 1260ucucagcaau guuuaguauu uucuuuccug ccuuugguuc cugugcuccu aagcuaaccu 1320gcuguuuucc acaucuccau uugguguuag cgcaagauuc agcuaguggc ugagaugugg 1380cacagaccuu aacagugcaa gcaucucagc ucgucuuacu gcaucagaug cugguucuuc 1440aagaucccau uuaaauuccu uagugacuaa aaccauugug cauuguagag ggcgucuauu 1500uauauucugc cugagaaagg aagugagcug uaaaggcuga gcucucucuc ugacguaugu 1560agccucuggu uagcuucguc acucacuguu cuugacucag cauggcaauc ugaugaaauu 1620cccagcugua agucugcaga aauuuccgaa uuc 165343485RNAHomo sapiens 43uuuuuuuuuu uuuuuucaug uuuaauaguu uauuucuuau uuuguugcuu auaucuucaa 60uaaaucauuu ugcagguuuu guuacagauu uuugauaagc caacucaagu acugauuuuu 120cauccucucu gaaaguuuua aaccaggaaa ggaaaacguu ccauggaauc caucuuccac 180auggugauga gucacaugaa cuccaacauu cugaagccgc uugacauaca ugaguccauc 240aucucuuagg acaucauacu ggcaagugau gauauagguc uuagguaaau gaugcaauau 300auugucauug gccaacagag ggcaugccuu cacaucuaug aacccuggau acuuuugagc 360cagcucagaa cuaccaggag ugggauuuuu guaaacggga cuuuucuugu aucucucagg 420gagcaaggaa cuccaauuca caaacuguaa caaguggcua gauuccaugg guacauguug 480guuga

485443449RNAHomo sapiens 44gagcacccgg gacccuggga ccacaacgca cuugcucccu cucgaccgcg cuccugaccc 60gcagcccucg ccaacccuac ggauccuaac caccgccagc cuaggugggc gucaggauga 120aggcagcccg cuucgugaug cgcagcgcca gcucgcugag cagcgccagc cuggucccca 180gggaggucga gcuguucucc cgcuacagcc cguccccgcu guccaugaag cagcugcugg 240acuuugguuc agaaaaugcc ugugaaagaa cguccuuugc uuuucugcgg caagagcugc 300ccguccgccu ggccaauauc cugaaggaga uugacauccu gccugaccgc uuagugaaca 360cuccuucggu gcagcuggug aagagcuggu auauccagag ccugauggau uugguggagu 420uccaugagaa gagcccagaa gaccagaaag cccugucaga guuuguagac acgcugguca 480aaguucgaaa cagacaucau aauguggucc cuacaauggc ucaaggcauc cuggaguaua 540aagacaccug cacaguggac cccguuacca aucaaaaucu ucaguauuuu uuagaccggu 600uuuacaugaa ccgcauuucu acucggaugc ucaugaauca gcacauccuc auauucagug 660acucaaagac gggaaaccca agccacauug gaaguaucga cccaaacugu gaugugguag 720caguagucca agaugccuuu gagugugcaa agaugcucug cgaccaguau uaucuaacau 780cgccagaauu aaaccucaca caagucaaug gaaaauuucc aggccaacca auccacauug 840uguacguucc uucacaccuu caccacaugc ucuucgaacu cuucaagaau gccaugaggg 900ccacggucga gcaucaagaa aaccguccuu ccuugacccc aguagaggcc acugucgucu 960ugggaaaaga agaccuuaca aucaagauuu cugaccgagg aggcgguguu ccucugagga 1020uuacugaccg ccucuuuagu uacacguacu ccacugcucc aacaccugug auggacaauu 1080cccggaaugc cccuuuggcu gguuuugguu auggcuugcc aauuucucgu cucuacgcca 1140aguauuuuca aggagaucug aaucucuacu cuaugucagg uuaugggaca gacgcuauca 1200ucuacuuaaa ggcuuuaucu ucugagucug uagaaaagcu cccagucuuu aacaagucag 1260ccuucaaaca uuaucagaug agcuccgaag cugaugacug guguauccca agcagggaac 1320cgaagaaccu ggcgaaggag aagcuggcag ugugaagcgg augacgccug acauuuuacg 1380ggaucaaagu gggucugugg cauugcugcu ucgugaaugu guguggacuc uaguuuccgc 1440aaaacaacgc aacacaaaac caagcaagca aaacacaaac acgaguacaa accuugaccu 1500gaugagggac agagcuuggu uggaugaccc gggagaaguc agggcagggc uccaggggau 1560aacagguguc cugcuucucc uuuggcaaug caaaaugacu ccugacuguu ccaaauacug 1620aaaagaaguc ugccucugag uuacagcucu uucucaacaa guacagaguu ugaggcuugc 1680aguugcaaca gcuggauguu uggugguucu ugcugccagc caaauaaauu gguguuuagu 1740gaacauuuuc aguguuuccc cgccaugcaa agcuuggcgc cuugggagaa auguguguaa 1800auguacauug uauagguauu agugugcucu agaaaggaca ggauggaagg aaucaaagca 1860cuuuaucgag cuuguggcug agcauugcag ccuaugugca aacccagagg aaaaguaucu 1920cugucaagac agcuccagua ucaugcagcu uuuuauguuu gcacucaaaa agccagugcc 1980uucuggcugg ugccgaggcu ugggugaaau guuaaauaug cacugaccuc agaaagucga 2040guucaaaagg gagauaaaau ugccaaagug auccaaggau ugugcauguu gggaaaccca 2100uaugagagaa aggauucuca uacuuagaac uuuccuauga agaaauggug guaaacuuuc 2160ucuaccuaga aguaguggaa auuucaaggu caucuuaaaa aagaugugcg uuguauauuu 2220uaacuacauu cucuacacuc uaacauuaac auaucuauuc aaauuugucu aguugccaau 2280ugucuucaga gugugaaaau uuaaauccuu cuugaaguau cuuucgugag aguaguaugg 2340aaguaaaacg uucucauauc aggaggaugu cauuugugaa gcauggggac aucaugaacu 2400agugaugugc gugaggcuug ggaggcugaa ggguaaggau cagcgggagg ccauccaugu 2460aggagagaga auuaaaacga ggagcgaggg aagcaaugga gagagggaag caagaaagga 2520accagaaggc uggcaucauc cuauuuccca caggcuaacc caagggaugc ucugugccuu 2580uccuggggag ggaagggggu gaacugguag auuugaaagc aguauggcuu cuucuguggg 2640ucucccucuu acuagacaag gugaaaugau aauucguguc aaauuaaugu gaaauuuuuu 2700uccugcauug uaauauuaug aggccugagu cgcaguugag uuugaaauuu guauuuaauu 2760ucacagugac cuagagcuaa ggugcucccg guuguggcaa uaggagccac aaguauuuuc 2820uuucuuucuu ucguucuuuc uuucuuucuu ucuuucuuuc uuucuuucuu ucuuucuuuc 2880cuuccuuccu uccuuccuuc cuuccuuccu uccuuccuuc cuucuuccuu uccuuuucuu 2940uucucuucuc uucuuuucuu uuuucuguuu cuuuuucuuu uuuugcauug uagauguugu 3000ccuuaaaaga ucagggcagu gacuuucaca gcaggacuuu gacucccaca uugguugauc 3060acacaaaacu gucagcauuu ggguaaucug auguauaguu guuuuguugc ugauguuucc 3120auugaaauuu cagcucugag uuugugcaca ugaauacuua cuuguguuua ccaaaggucu 3180aaggcauuug guuacuuaac ccaaauaucc ugaacugugc guaaaguaau agagaaaagc 3240uuuagggucu caauaguguc accuguguaa aucaaaucaa aauagccuuc ccuauuauuu 3300augaacccau gggagacuuu aaacucuugu agauagaugc uaaaugccca ggcccacuua 3360acuuauuaau gugugaauua cauuuauguu uuuaguuuau augcaaagaa uugugauaau 3420uuuauaauaa auauuuuuau uauaauagu 344945226RNAHomo sapiens 45uuuucuuuuu uuuuuuucuu cucuuuuuuc ugccaccaac agcacugugc aguuuauuaa 60ccauucaugu acaguagcca ucuggggaga uugggacaga auugggaucg caaaguggau 120agauauucag caucuaaugg guuggcagaa gccgccauau acucuucaca aauaucuucc 180acagucaaua cagaacuagc cauuauccca gcacaccgau uugugc 22646952RNAHomo sapiens 46agccaggagc cucgccccgc agcugcacag agagcaaggg uauaggcacu aacuuguuug 60cagagacccc aucaccuucg ggagcucagg ugcgcaccuu gcaaacucca cuuucugcau 120cugccacuga gcccgcggga gccucggaaa gagccauggc caacgcgggg cugcagcugc 180uggguuucau ccuggcuucu cugggaugga ucggcuccau cgucagcacu gcccugcccc 240aguggaagau uuacuccuau gcuggggaca acaucgugac cgcucaggcc aucuacgagg 300gacuguggau guccugcguu ucgcaaagca ccgggcagau acagugcaaa gucuucgacu 360ccuugcugaa ucugaacagu acuuugcagg caacccgagc cuugauggua auuggcaucc 420ugcuggggcu gaucgcaauc uuugugucca ccauuggcau gaagugcaug aggugccugg 480aagaugauga ggugcagaag auguggaugg cugucauugg gggcauaaua uuuuuaauuu 540caggucuggc gacauuagug gccacagcau gguauggaaa cagaauuguu caagaauucu 600augaccccuu gacccccauc aaugccaggu augaauuugg ccaggcccuc uuuacuggcu 660gggccgcugc cucccucugc cuucugggag guguccuacu uuccugcucc uguccccgga 720aaacaaccuc uuacccaaca ccacggccuu aucccaagcc aacaccuucu agugggaaag 780acuaugugug acagaggcaa aggaagagau cuuccuggag caaauacaaa auggacauug 840aaccuaggau ugacauuaac gccuuagacu guugaugaug guuaucggaa cugugguaga 900acagaaggaa gcauauuuuu auacaucccc auggcuaugc aggccuuggc ug 952471777RNAHomo sapiens 47cggcacgagc ggccacugac cgagaagugc ccccgccugg agucagccug ggggcaggcc 60aggguccacc agaccccggg augaccgcag ccagucgggc caaccccuac agcaucguau 120caucagagga ggacgggcug caccugguua ccaugucagg cgccaacggu uuuggcaaug 180gcaaggugca uacacggcgc cggugccgca accgcuucgu caagaagaac ggucagugca 240acauugaauu cgccaacaug gacgagaagu cacaacgcua ccuggcugac auguuuacca 300cgugugugga cauccgcugg cgcuacaugc ugcucaucuu cucucuggcc uuucuugccu 360ccugguuguu guuuggcauc aucuucuggg ucauugcugu cgcccacggg gaccuggagc 420cagccgaggg ccguggccgu acacccugug ugcugcaggu ccacggcuuc auggcagccu 480uucucuucuc cauugagaca cagaccacca uuggcuacgg gcuacgcugu gugacugaag 540agugcccggu ggcugucuuc augguggugg cgcaguccau ugugggcugc aucauugacu 600ccuucaugaa uggugccauc auggccaaga uggcacggcc caagaagcgc gcacagacuc 660ugcuuuucag ccauaaugcc gugguggcuc ugcgugacgg caagcucugc cucauguggc 720gcgugggcaa ccugcguaag agucacaucg uggaggccca ugugcgggcc cagcucauca 780agcccagggu cacagaggag ggugaguaca ucccacugga ccagauugac aucgaugucg 840gcuuugacaa gggccuagac cguaucuucc ugguaucacc caucaccauc uugcacgaga 900uugaugaggc cagcccacug uuuggcauua gccgucagga ccuugagaca gacgacuuug 960agauuguggu cauccuggag ggcaugguag aggccacagc caugaccaca caggcucgca 1020guuccuaccu ggcuaacgag auccuguggg gccaccgcuu ugagccagug cucuucgaag 1080agaagaacca guacaagauu gacuauucac acuuccacaa gaccuacgag gugccaucua 1140caccccgcug cagcgccaag gaccuggugg agaacaaguu ccuccugccc agcgccaacu 1200cuuucugcua ugagaacgag cuggccuucc ugaucagaga ugaggaggac gaggugucua 1260ccgaccggga uguccgcacc ccucagcccg agcaugacuu ugacagacug caggccagca 1320gcgcugcccu ugugcggccc uacagacggg agucggagau uugaaugccc uuggcuuaga 1380ugcagcacca cccugaccac aauagguccc augucccuug ggggccugcg uuugagcaga 1440gcaggccgaa agccucgggu cacagacuca guagcaucuu agucuuuuuc auguuuuuuc 1500gcaguagcuu gggaaaguug gcgggagcgu ggauggccca aaugacuggc ucacggccuc 1560ggaggcugau guauacccau gggcaaggag gugacuucuu gggguagggu ugcucaggag 1620uuagggacuc ugcuggaggc cuuaggugca ggucccaacc ccggugggag gaggcugugu 1680auguacacuu cauugguuuu uaacuugggc aagacuguuu acaaaccaaa acaaacaaac 1740aaacaaucca aaaaaaaaaa aaaaaaaaaa aaaaaaa 177748175RNAHomo sapiens 48uuuuuuuuuu uuuuguuccu uuuuuggaau ucccaaagcu gguuuuaauu ucaaaaaauu 60augaggucuc uucccacacu ggggauaaug ggaugggaua gcccaaacua uuaucccagu 120ucaaccccag ccugguccaa acaccauuac ugucacuggg cccugucauu ucacc 175491629RNAHomo sapiens 49uccucguccu cgucuguucc aucuucucca aauagcucua acugugaugc caacggcaau 60cccaagaacg cugauaucuc uagcaucgau gguguucuga agagugaccg cacagauugu 120ccugugaaaa caggcaaaac cagugcuccu ggcaugacua 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ugccucgcaa ggaucccaga acaagcagcc uuucacuauu 420gacaacuuug agauugggcg uccuuugggc aaaggcaaau uuggaaacgu guacuuggcu 480cgggagaaga agagccguuu caucguggca cucaagaucc ucuucaaguc ucagauugag 540aaggaggggg uagagcacca gcuucgccga gagaucgaaa uccaggcgca ccugaaacau 600cccaacaucc uucaacucua caacuacuuc uacgaccagc agaggaucua cuuaauccug 660gaauacgccc cucgcgggga acucuacaag gaacugcaga agagucggac cuucgaugag 720cagcggacug ccacgaucau ggaggaacug ucagaugccc ugaccuacug ccacaagaag 780aagguaauuc acagagacau aaagccggag aaccugcugu uaggucugca gggagaacug 840aagauugcag acuuuggcug gucggugcau gccccauccc ugaggaggaa gaccaugugc 900ggcacgcugg acuaucugcc cccagagaug auugaggggc gcaugcauaa ugaaauggua 960gaucuauggu gcaucggggu gcucugcuau gaacugaugg uggggaaccc ccccuucgag 1020agcccuagcc acagugagac guaucgucgg auugucaagg uggaccugaa guuccccucu 1080ucugugccuu cgggcgccca ggaccucauc uccaagcugc ucaaacauaa ccccuggcaa 1140cggcugcccc uggcggaggu ugcagcucac ccuugggucc gggccaacuc aaggaggguu 1200cugccucccu cugcccuuua gccugcuccu ugguuuuuug ucccugucau uuuucagugu 1260ucuuuguaug ucuguguaug uguucugaga agggguggga acuggaaacu auuccuagcu 1320ccaguucuag gggaucugau cucucuucug accucuacag gcaaaauuag gcaccccugu 1380ggugcacaua uaugcacgcc aaacacauga aguuacaaac aaacaacaaa cacacagaua 1440gugcuggaga gauggcucgg caguuaaaag cacuggcugc ucuucccagg aaccuagaac 1500ucaauucuag cacuacaugg ugcucacggc cacugucugu aacacccagu ccuggggaau 1560cuggggccuu cgagccucug caggcacuag gcauggaugu gguauacaug uaugcaggca 1620aaacacccau gcacugacuu uuaagaaacc cucuagucug auuccuuuca auuugucaaa 1680uguugaaugu uauuuuuaaa auauuauaag ccauuuaaua caauuuuucu uugaaacaug 1740guauagccua gucugucuua aauucagaaa aauuaugaag aacaacauuu uauaauaaag 1800ucuuaaaugu uucauguuuu ug 1822562663RNAHomo sapiens 56uugccuagga agggcgcguc gucucucugc ucguccggcu gugacgggga agggucccgc 60ugcguuuugg ucacugugag uaccaaguuu gggggauccc cgagggacuc ucgagagcuc 120auuuuaggga ugcaggggcu acuccccggu gguagagagc uuucuaguug gcaggagguu 180ucguaugugg aggaggccag cuuaggcaga aagcacaugu ucucagagau gaggacaaga 240cuaagaccgu cuaaucccug aucuuuaccu uccggcccgc ugaccugggc cuggaugcua 300aagcccucug cuuucgucua aacagcgcua aauaguaaac aguauugccu aagauaaaug 360cggauuauua cccgauucag ugucgggaaa aggcagcuag gagagagcgg cuggcacgug 420guaagcacac gguaaguuuc gguuaaauua aaacaaccau ccguugagca ucucuuagca 480agcuccuucc acccuucaaa caaucaguga uagugcgucu guuucacuga uuagggagcu 540aaggcuccaa cagcagcaaa ggaacuaauc cgccucugau caacauggcg uuucuuacag 600ggcauuccuu auacgcuuuc ccacgugcgu aacaggaauc ggguguuccc ggguuuuguu 660uuguuguugu uguuuuuguu uuguuuucuu agugaaagag gcaggguggg cuccaggccg 720cugaggauua auaaagagau ucuaugagga ggaaauaaca ggcagguggu augaucgagg 780caaggcccug aggaaggcuu ggguggggug aguagaacca gagccggaag uccacucagc 840agccuggggc acuuaaagcu ucugcugggg caaaugguaa ggcggcguaa ggucacauuc 900cuuucauuuc uuccagacuc aggaggagac cacaccuucc ggagaaccag gccugaaccg 960agguacuauu uuguagcucu cagaagccag gacucugcaa cacuguuugc ugccugugga 1020ucuucuauau ucacaguguc ccaguugcuu cugaucuacc acuguuagau acuucugcca 1080cccauccuaa gaguauaguu guucuuggaa aggagucuca gcugcuguca gcaggagucc 1140cucauucgac uccugugguu gcccuuucca ccaugccaaa gaauaaaggc aaaggaggca 1200aaaacaggcg cagagguaaa aaugaaaaug aaucugagaa aagagaguug guguuuaaag 1260aggaugggca ggaguaugcu caggugauca aaaugcuggg aaauggacgg uuggaagcaa 1320ugugcuuuga cggugugagg aggcugugcc auauaagagg gaagcugaga aagaagguuu 1380ggauaaauac cucggacauu auauugauug gucuacgaga cuaucaagau aacaaagcug 1440auguaaucuu aaaguauaau gcagaugaag caagaagucu gaaggccuau ggagaacuuc 1500cagaacaugc caaaaucaau gaaacggaca cauuuggucc uggggaugau gaugaaaucc 1560aauuugauga uauuggagau gaugaugaag acauugauga caucuagccu gaccuaagca 1620ugcuaccuuc caaguucucu gaagauagcu ccacacagug gcaucuugac cuucaucugu 1680uaaguaaaac uucauggcau guguaugacu uguuaaugca agcuaaugaa uuuuauuuuu 1740ugaaguacua uauuucuuug aaaaccaaag auguugaguu aucaucuuaa gugacauguu 1800aacacuuugu gcuuuugaau auaauugaac cuagcgcaca gcagugagca cuguuaagag 1860acugccuuuc cauuuguagc uucauuucug gcacgggagu guuuuguguc agcaguucug 1920ccagguggcc aucgaugagc ugaaguaagu ccuaguccag cacaucugcu ucaggccuuu 1980guacucuagu caucuggcug cguucgagac uucucagcag aacuuauaga uguguacggc 2040ugcacuugga gucagacaag auauggcuac uuuuguacuu auggagccau gccauuuuau 2100acuuucacgu uguauacauu cguuugaccc uuuaaguugu ugccacccau aaaaaggcau 2160cuuacagugc aguuuuuaaa uuacaugggu agcaauuuug aguuuuaaaa auuagucauu 2220gcagaaauua aauacuuaga ggagauaauc cauuaucuug auuuuaggaa uauaauaguu 2280gacaauguuu auauauaauu uuacuucucu aaggcauacc caaaaauaga aaaugaaaaa 2340gagcagugag ucuguucuga ugcuugcauu gcauagagaa guuuuccaac aaagcagcug 2400uuaauaacac auaaaauaug uuuuacuuug caaaguaggu uguguuaagu cauuuucaaa 2460aaguuaccua cuauaucgag gcucuggaua auuacuaugu guugauuaaa guuaguuaca 2520gaauuguaca agcuaaguuu uccuuaaacu aagcuuaggu uaaagggaga ggagccacag 2580cucaaugaaa acacgguucc uguuuucuaa auggaggcgc ccagaaacac aauaaaacau 2640guugguacaa aaaaaaaaaa aaa 266357884RNAHomo sapiens 57caugauccca gccacccgcu cgcuucucug ugcagcgcug cugcugcugg ccaccagccg 60ccuggccaca ggggcgccua ucgccaauga gcugcgcugu cagugccugc agaccauggc 120ugggauucac cucaagaaca uccagagcuu gaagguguug cccucagggc cccacugcac 180ccaaaccgaa gucauagcca cacucaagaa uggucgcgag gcuugccuug acccugaagc 240ucccuugguu cagaaaauug uccaaaagau gcuaaaaggu guccccaagu aacggagaaa 300gaagacagac ugcucugaug gcaccgucug gugaacgcug gcuucugaca acacuauaca 360auuucuuuug aggguccuau uuauuuaugu auuuauuuau uccacaaagu gugugguuuu 420uauuuuacau uaauauuuaa caguguggau acauuucauc gaugguaguu caguucugcu 480uguucaguuu aaagauggua ggcuuaaaau auuucauuaa aacuaauauu uauugggaga 540ccacuaagug ucaaccacug ugcuaguaga aggguguugu gcgaaaagaa gugcagagag 600auagaguuua guauuauguu uuguauguau uagggugagg acaugugugg gaggcugugu 660uuguaugucu ugaaaagaau gucaguuauu uauugaaagu cgucuuucau auuguauggu 720caacacgcac guguugacgc uucccuugga cauuuugugu cuaguuggua gcccauaaug 780ggcuuuuaca uucuuuaacc cuguuucucc uggucucguc ucgcucggga cagagacguu 840caaaggacug uuacaaauga aguaaaaaua aaaguuuuau uaag 884581310RNAHomo sapiens 58cgucucccgc auucgucugg gccgugcacc ugcccgcuag cucgcugcac uaccguugcc 60cacaagccaa caugcugccg agauugggcg gccccgcgcu gccgcugcuc cugccgucgu 120ugcucuugcu gcugcucuug ggcgcgggcg gcugcggccc cggggugcgc gccgaggugc 180uguuccgcug cccacccugc acgcccgagg cucuggccgc uugcgggccc ccacccgacg 240cgcccugcgc cgagcuggug cgagagcccg gcugcggcug cugcuccgug ugcgcacggc 300aggagggcga agcaugcggc gucuacaucc cgcgcugcgc ccagacgcua cgcugcuauc 360ccaacccggg cuccgagcug ccccugaagg cgcuugucac aggcgcgggu accugugaaa 420agagacgcgu gggcaccacc ccacagcagg uugcagacag ugaugacgac cacucugagg 480gaggccuggu ggagaaccac guggauggga ccaugaacau guugggaggu gguagcagug 540cuggccggaa gccccucaag ucaggcauga aggagcuggc uguguuccgg gagaagguca 600augaacagca ccggcagaug ggcaagggug ccaaacaccu cagucuggag gagcccaaga 660aguugcgccc gccucccgcc aggaccccuu gccagcagga guuggaccag guccuggagc 720ggaucuccac caugcgccuu ccggaugauc ggggcccccu ggaacaucuc uacucccugc 780acauccccaa cugugacaag cauggccggu acaaccuuaa gcagugcaag augucucuga 840acggacagcg cggggagugc ugguguguga accccaauac cgggaagccc auccagggag 900cucccaccau ccggggagac cccgagugcc aucucuucua caacgagcag caggagacug 960guggggccca ugcccaaagu gugcaguaaa ccccagccag ucggugccug gcuuccccau 1020cccgaacacc agcagaaaug gagggcguca gggugacggg uguggaggag uucccaguuu 1080ugacacaugu auuuauauug gaaagagacc aacacugagc ucagaagccc cccucugacc 1140ccccccagcg gcuguuaacu gaaccucccu ugcuucuguu agagagggga agggugguau 1200ggagggcacu ggguacaggc cugggaaugg ggaaagaaau uuuuauuuuu gaaucccugu 1260gucucuuuua cuuaagauua aaggaaggaa aaauaaaaaa aaaaaaaaaa 131059487RNAHomo sapiens 59gaugugaaaa acguuuuuau uauaaucucu uaaacuuuca guguauauuu ucauuacaau 60cauugguaca auaaauaugg aaaugcugag cagacaauua ucacaguggc cuaugggcug 120agggacaggg acccaggaau acuguuaccc uggauacuuc cucagggcca aucaggaggu 180cuucaaagag uauugagagg gagagggaua gaaauauuau uaagacuguc agugcagcaa 240cuuuuagaau gucuauuaaa gccauggaua caggauuuac gauaacagaa gauggauacu 300aaaaaagaac agagacucaa guucuccugu aagaggcaga agaaacauug cagaagccag 360ugccuuccuc ggguccccag ugugugcccc cauccaccca cgcauugugu uggucaucuc 420caccugcccu gugcccagcc cugugcccac ccagguucuc cuaggcaccc accuugcacc 480ucgcacg 487601430RNAHomo sapiens 60gaauucugcg cgguuuugca uuuuuugggu cagauuggcu uuuuacauga uuacgaagcu 60ccaacgacua gaccacaggg accgucgccu uggcggccga gcagucguau ccaacuugga 120gacagccagu ucgccgugug ucugucuguc cuucaucgca gucauggaga gagccagucu 180gauccagaag gccaaguugg cugaacaggc cgaacgguau gaagacaugg cagcuuucau 240gaagagcgcc guggaaaagg gcgaggagcu cuccugcgag gagcgaaacc ugcuuuccgu 300agccuacaag aacguggugg gcggccagag agcggccugg aggguccugu ccagcaucga 360gcagaagagc aacgaggagg ggucagaaga gaagggcccc gaggugaaag aguaccggga 420gaagguagag accgagcuca gaggugugug cgacaccgua cucggccugc uggacucgca 480ccucaucaaa ggggcuggag augcagagag ccgcgucuuc uaccugaaga ugaaggguga 540cuacuaccgc uaccuagccg agguggccac uggcgaugac aagaagcgca ucaucgauuc 600ugcccgguca gccuaccagg aggccaugga caucagcaag aaggagaugc cgccuaccaa 660ccccauccgc cugggccugg cccugaacuu uucagucuuc cacuacgaga uagccaacag 720ccccgaggag gccaucucgc uggccaagac caccuucgac gaggccaugg ccgaccugca 780cacccucagu gaggacuccu acaaggacag cacccucauc augcagcucc ugagagacaa 840ccugacgcug uggacagccg acagugcugg ggaagagggu ggugaggcuc cggaugaccc 900ccacaucuga agcagcggaa aaacaacccg gguuggcuug gccuuccagu ccccagccug 960gcauagagga uuaaaaggga gugggauuuu gccuuuccca aacccugaau guucagcaac 1020accuugggaa ggucuuucga agggggcgca gccaagcuga agccaccagg gcagggaauu 1080uaauuuuucg uguagcuguu ugggugggug uuucccaaaa ccaucccacc ccuguuuuuu 1140gaacccccuc cccaauucuu cccccugagc cucccucggg caccuguugc uuuuggaucc 1200gaauaaucca ggagguuccc cacccugugg cugagaaaug gacuguggca agggcugugu 1260gugugugaga gagagggaaa cucugugugu guguguguga gagagagaga gagagugaau 1320gagagggaaa aaguuugcug ggugugacca ugguaccaau caauaaaguu gcccugugag 1380acucaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 143061268RNAHomo sapiens 61uuuuuuuuuu uuuuuuuaaa uaccaaaaca uuuaauugaa auaccuguau aaaaaauaug 60aucuucagac auuucacacu uuugaacuua uacaacccca ccccugaugc uuagucacac 120cagggucaca gaaacacagc ugcuaaaaua aauuaagggc uugagacucu gucccccaac 180cccagcuuuc agagccagca agcagacugu acaaggucaa uaauuuaaac cccuccccag 240cgcagagugc ucagggugac agggucuc 26862377RNAHomo sapiens 62uuuuuuuuuu uuuuuuuaau guaacgaccg gugugcuuca guuuguuuag cagaaccacu 60cucuugaauc acauuaacuu uugagauuua aaaaaaacaa aacaaaaaaa aaaaaaaaca 120acaaaaaaaa aaccaacccu ccauagcaca gcugucuuuu augcaagcaa gagcacaccu 180acuccagcau gauuugucau cuaaagacuu gaaaacaaaa caacaacaac aaaaaguuac 240uuauagucaa uggauaagca gaguccgaau uuacacuaau caagacagac cuucgagggg 300ucacgauaag uccggaacuu ucaaaccuug cuucguauga auuguacuau cugaacauaa 360acugcacuuu uauuuuc 37763756RNAHomo sapiens 63augagacucc acagccucau ccugcucucc uuccuucucc uggcuacuca ggcguucuca 60gaaaagguca gaaagagagc caagaacgca ccacacagca cagcggagga ggggguagag 120gguucagcuc ccucguuagg gaaggcccag aauaagcaga gaagcaggac aucuaaaucu 180cugacgcaug gcaaguuugu caccaaagac caagccacau gcagaugggc ugugacugag 240gaggagcagg gcaucagccu gaagguccag ugcacacaag ccgaucagga guuuucuugu 300guuuuugcug gugacccaac ugacugccuu aaacacgaca aagaccagau cuacuggaaa 360cagguugccc gcacgcugcg caaacagaaa aauaucugca ggaacgccaa gagugucuug 420aagaccagag ugugcagaaa gagauuucca gagucuaacc ucaagcuggu gaaccccaac 480gcacguggaa acacgaagcc caggaaggag aaagcagagg ucuccgcaag ggagcacaac 540aagguccaag aagcugucuc cacggagcca aacaggguca aagaagacau cacacucaau 600ccagcugcga cccagaccau ggccauuaga gauccagagu gucuagagga uccagaugug 660cucaaccaga ggaagaccgc ccuggaguuc uguggggaau cuuggagcuc cauuugcaca 720uucuuccuca acauguuaca ggcgacauca ugcuaa 756644701RNAHomo sapiens 64cgggucgacc cacgcguccg cccacgcguc cggcggagcu ucuggguugc gggccgaaac 60ggcaagcgga uggagggcgc ucgaacggcc aggugucgug auuaaauuag ucagcccuca 120gagacaggcg uccuaccucc uuuauccaga ccucaaaagc cccguugugc acccguggug 180gcuucuucac cuucccuguu ucguccucca cuguauggcc cagacaugag ugguccccua 240gaaggggccg augggggagg agaccccagg cccggagaac cuuuuugucc uggaggaguc 300ccauccccug gggccccgca gcaccggccu uguccaggcc ccagccuggc ugaugacacu 360gaugcaaaca gcaauggcuc aaguggcaau gaguccaacg gacccgaguc caggggcgca 420ucucagcgga guucucauag uuccucuucu ggcaauggca aggacucagc ucugcuggag 480accacugaga gcagcaagag uacaaacuca cagagcccau ccccacccag cagcuccauu 540gccuacagcc uccugagugc gagcucagag caggacaacc caucuaccag uggcugcagc 600agugaacagu cagcucgagc caggacccag aaagaacuca ugacugcacu ucgggagcuc 660aaacuucgac ugccaccaga gcgucggggc aagggccgcu cugggaccuu ggccacacug 720caguacgcuc uggccugugu caagcagguu caggcuaacc aggaauauua ccagcagugg 780agucuggagg agggugagcc uugugccaug gacaugucua cuuacacccu ggaggaauug 840gagcauauca cauccgaaua cacacuucga aaccaggaca ccuucucugu ggcugugucc 900uuccugacag gccggauugu cuauauuucg gagcaggcag guguccugcu gcguugcaaa 960cgggaugugu uucggggugc ccgcuucuca gagcuccugg cuccccagga uguggguguc 1020uucuauggcu cuacuacacc aucucgacug cccaccuggg gcacuggcac cucugcaggu 1080ucaggucuca aggacuucac ccaggaaaag ucugucuucu gccgaaucag aggagguccu 1140gaccgggauc cagggccucg guaccagcca uuccgccuaa ccccauaugu gaccaagauu 1200cgggucucag auggagcccc ugcacagccg ugcugccuac ucauugccga gcgcauccac 1260ucugguuaug aagcuccccg gaucccuccu gacaagagga ucuucaccac ccgacacaca 1320ccaagcugcc ucuuccagga uguagaugaa agggcugccc cacugcuggg uuaccuuccc 1380caggaucucc ugggggcucc aguacuucuc uuucuacauc cugaggaccg accccucaug 1440cuggccauuc auaagaagau acugcagcug gcaggccagc ccuuugacca uuccccuauu 1500cgcuucugug cucggaacgg

ggaauauguc accauggaca ccagcugggc cgguuuugug 1560caccccugga gccgcaaggu ggcuuucgug uugggucgcc auaaagugcg cacggcaccc 1620cugaaugagg acgucuucac ucccccagcc cccagcccag cuccgucccu ggacucugau 1680auccaggagc ucucagagca gauccaucga uugcugcugc agccugugca cagcuccagc 1740cccacggggc ucuguggagu uggcccucug auguccccug guccucuaca cagcccuggc 1800uccuccagug auagcaaugg gggggacgcu gaggggccug ggccuccugc uccagugacu 1860uuccagcaga ucuguaagga ugugcaucug guaaagcacc agggacaaca gcucuucauu 1920gaaucucggg ccaagccccc accccggccc cgccuccuug cuacagguac auucaaagcc 1980aaaguccuuc ccugccaguc cccaaacccc gaacuggagg uggccccagu uccugaccaa 2040gccucguuag ccuuggcccc ugaggagcca gagaggaaag aaaccucugg cuguuccuac 2100cagcagauca acugccugga cagcauccuc agguauuugg agagcugcaa cauucccagu 2160acaaccaagc guaaaugugc cuccuccucc uccuacacug ccucuucagc cucugaugau 2220gacaagcaga gggcaggucc aguuccugug ggggccaaga aagauccguc gucagcaaug 2280cugucugggg agggggcaac uccucggaag gagccagugg ugggaggcac ccugagcccg 2340cucgcccugg ccaauaaggc agagagcgug guguccguca ccagucagug uagcuucagc 2400uccaccaucg uccauguggg agacaagaag cccccggagu cggacaucau caugauggaa 2460gaccugccug gccuggcccc uggcccagcc cccaguccgg cccccagccc cacaguagcc 2520ccugacccaa ccccagaugc uuaucgccca gugggucuga ccaaggccgu gcugucccug 2580cacacacaga aggaagagca agccuuccuc aaccgcuuca gagaucuugg caggcuucgu 2640ggacuugaca ccucuucugu ggcccccuca gccccuggcu gccaccaugg ccccauuccc 2700ccuggucgcc gacaccacug ccgaucuaaa gcaaagcguu cccgccacca ccaccaccag 2760accccccggc ccgaaacucc cugcuauguc ucccauccuu caccugugcc cucuucugga 2820cccuggccac ccccaccagc cacgaccccc uucccagcaa ugguccagcc cuacccacuc 2880ccaguauucu ccccucgagg aggaccccag ccccuucccc cugccccuac aucugugucc 2940ccugcuaccu ucccuucucc cuuagugacc ccaauggugg ccuuggugcu cccuaacuau 3000cuauucccua ccccaccuag uuauccauau gggguguccc aggccccugu ugaggggcca 3060cccacgccug cuucccacuc gcccucucca ucccugcccc caccaccucu cagccccccc 3120caccgcccag acuccccacu guucaacucg agaugcagcu ccccacucca gcucaaucug 3180cugcagcuug aggagucccc ccgcacggag gggggcgcug cugcaggagg cccaggaagc 3240agugcugggc cccugccucc cagugaggag acugcugagc cagaggccag auugguggag 3300guuacugagu cguccaauca ggaugcacuu ucaggcucca gcgaccugcu ggagcuacug 3360cuccaagaag acucucgcuc gggcacaggc uccgcagccu caggcucccu gggcucuggc 3420cugggcucug ggucugguuc aggaucccac gaagggggaa gcaccucagc cagcaucacc 3480cgcagcaguc agagcagcca uacaagcaag uacuuuggca gcaucgacuc uuccgaggcu 3540gaagcugggg cugcucgggc caggacugag ccuggggacc aggucauuaa gugugugcuc 3600caggacccca ucuggcugcu cauggccaau gccgaccagc gugucaugau gacauaccag 3660gugccgucca gggaugcagc cucugugcug aagcaagacc gggagaggcu ccgggccaug 3720cagaaacagc agccacgguu cucagaggac cagaggcggg aacugggugc ugugcacucc 3780uggguccgga agggccagcu gccucgggcc cuugauguga uggcgugugu ggacuguggc 3840agcagcguuc aagauccugg ccacucugau gacccgcucu ucucagaacu ggauggauug 3900gggcuggagc ccauggaaga ggguggaggc gaggguggug gguguggugu uggcgguggu 3960gggggugaug guggugagga ggcccagacc caaauugggg cuaaggguuc aagcucucag 4020gacucugcca uggaggaaga agagcaaggu gggggcucau ccagcccagc uuuaccugca 4080gaagaaaaca gcaccagcua gauccauuuu ggggccgcuu acagcagucu aaugagaggc 4140uuccuuucga ccauguuggg guucuuauaa cucaagauac agcuggacca accaauagga 4200aacugcccca gcuucuccca acauaggggg cuggaccccc auuaccagcc caggcacagg 4260agcugccucu agcuucuuag cagaguggaa guucucagcc ccauuuggag gauuguccac 4320gcccguccca cugaggagac gggcgggucu ucgguuaagg uugcugacaa gcugcugaag 4380uggucugucc aaaucccagc ugagccugag ucccagucgc aggguugggg cugcacuuau 4440uuauuuggga gagacagcuc acucucccac cucaccccaa gaugggagga ggggaaccug 4500ggaucugugu aggauccagg uccgugaacc ccuagcugcu ccaggguggg ggagguuggu 4560ggaccaugga gucccuggug cugccccuca ggugggaccc agguguucuc agcucuaccc 4620ucuaccaaug acauuugugu uuuugauauu gugucuguua uuuuuuuuuu aauacaaaau 4680gacaaaauga aaaaccaaaa a 4701653036RNAHomo sapiens 65gacagcggag cgcgguggcg ucgacgucua gugucucagu gcucccgucu guggcuaacu 60aagcagccag cagccaggca gcucgcgacc ugcggccagg cagccaacca ugcucaacuu 120cggcgcuucu cuccagcaag cuucggaggg gaaaauggaa cuaauuucug aaaagcccag 180agaggggaug caucccuggg acaaagcuga gcagagugac uuugaagcgg uggaagcgcu 240cauguccaug agcugcgacu ggaagucuca uuucaagaaa uaccuugaaa acaggccugu 300cacaccagug ucugauaccu ccgaggauga cagcuugcuu ccagggacgc cugaccuuca 360gacaguccca gcauuuuguu uaacgccacc uuacagcccc ucugacuucg aacccuccca 420agggucaaau cugacugcau cagcgccauc uacuggccac uucaaaucuu ucuccgaugc 480ugccaagccu ccaggcgcca cuccuuucaa agaggaggaa aagaauccuu uagcugcccc 540uccucuuccu aaggcucaag ccaccagugu cauccgucac acagcugaug cccaacugug 600caaccaccag uccugccccg ugaaagcagc uagcauccuc aacuaucagg acaauucuuu 660ccggagaaga acccacggaa auguugaggc uacucgaaag aacauacccu gugcugcagu 720gucaccaaac agauccaagc cugagcccag cacagugucc gauggugaug agaaggcggg 780cgcugcacua uaugacuuug cugugccuuc cucagagaca guaauuugua ggucucagcc 840agcuccuucg uccccagugc agaagucagu acuggugucu ucaccuacag uauccacugg 900gggagugcca ccccugccug ucaucugcca gaugguuccc cuuccugcca acaacucucu 960uguuagcaca guugucccca gcacuccucc uagccagcca ccagcugucu gcucaccugu 1020guuguucaug ggcacucagg ugccugaggg caccgucgug uuugugguac 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1920auauagaggc uggaaauuac gguacagaaa uggagcuaga aaaugaguuu guguuacaca 1980gagaugucau cuucuccuag aguuaucuug uuucuuauuc cuagucuuuc cagucaaauc 2040cguggaugua gcuaaguaua ucuaaaacuc auuuuuccac uauuguuggu auuugaaguu 2100gaacagcugu acauugcugu gggggagcca aaggauugga acccucauua auuuaauugc 2160uuggaaaugc agcuaaaauu cuucuuuggc auuuuguuuu gaaaguuuag gcauuuuacu 2220cuacuuuaga uuuuaguuug cuugcaguuu uuuguguaga uuugaaaauu guauaccaau 2280guguuuucug uaggcuuaaa auacacugca cuuuguuuag aaaaaaaucu ggagaugaaa 2340auauguauua uaaagaagag augucaagaa uuugagauaa cuccuugaga aaguuggcuu 2400uaugucauca gcaaaggaca cuuaacguca agcauacacu gugguuuuuu uguuuuuuug 2460uuuuuuuuuu ucaaauuaga aaguuuaaug accguuacag auggacagug ucuuuuuauu 2520uauaggaguu uuucaggaug ucagaguaga uagguaggaa aauuguuauu agaacauucg 2580cuucuaccuu gaaaaggaug uuaauguggu cauguucuua gcaccacagu gucugggcau 2640cugggaaacu ccgagacuuu uuuaaagugu caugauguga ucacaccugc aguuuggggc 2700aucgaaucca gggccuugca ugucuucugu aagagcucuc aucgcugacc uguauccccc 2760gcaagagcaa ugacuuuugc uaacaguauu ucuuuucugu uguaaagugg acagaugaua 2820cacuuggucg caaagguaaa uuauucaaaa uccacaguga aaaccucacc acacuuuccc 2880auuuaaacua uuuccauauc ucagagguuu cugacaugca aacuugaacc cuugaaagaa 2940gaguuuucuu aaaaauuaua aaaaaucacg aguuacaauu ugcacaauau uuuuuguuga 3000acuuuauacc uuguuuacaa uaaagacuuu ucuuug 303666526RNAHomo sapiensmisc_feature(7)..(7)n is a, c, g, or u 66uugucanuug cacgacagaa acugcaggaa gaugagaugc gccgggcugc ggaggagcgc 60aggaggguaa aggcugaaga guuagcugcc agacaaaggg uucuagaaaa aauugaaagg 120gacaaagcag agagagccaa gaaguauggu gguagugugg guucucgguc auccccacca 180gcaacagacc cagguccugu uccuucuucu cccagccagg agcccccuac uaagcgggag 240uaugaccagu gucguauaca gguuaggcug ccugauggga cuucacugac ccagacuuuc 300cgggcccggg aacagcuggc agcugugagg cucuacgugg agcuucaccg uggggaggag 360ccuggacagg accaggaccc ugugcaguug cucaguggcu uccccagacg ggcuuucuca 420gaggcugaua uggaacggcc ucugcaggaa cugggacucg ugccuucugc uguccucauu 480guggccaaga agugucccag cugaggguuc uccaucccac caucuc 52667425RNAHomo sapiens 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420acauagaagu ugcuguuagg aaggacuucg uaaucaucuc cuuccuuauc aauuaucuuu 480ugaaaaugaa cuucuacagu acaacucuga auauccuugu guucaucaga auuauguauc 540aguaccgaua gcuuuuuaga ccuuauuuuu ugugcucgau agccaaacac aaaaagcaug 600gaaucaauaa cauuggauuu uccacugcca uuugguccaa uaauacagga aaagcgcuua 660uggaaagguc ccacaaguuu cucuccagca uaggacuuga aguuuugguu uacaauauga 720guuaucauga gacgaggagc uccagcuuca cuggccaugg cuggaggugg ggguggaggg 780auacuauuca aaaucuccuc uaaacuucug uuauccagcu ccucaccugg aggcuuugcg 840ggugcagcgc uccccucacc uacuucgccu acugcaacuc ccaccaccuc cucucgauac 900aagaccgagc ucugucggac cuacucagaa agcgggcguu gucgcuacgg ggccaagugc 960caguuugcuc acggccuggg ugaacuucgc caagccaauc gccaccccaa guacaaaacg 1020gaacucugcc acaaguucua ccuccagggc cgcugccccu auggcucucg augccacuuc 1080auccacaacc ccaccgagga ccuagcucuc ccuggccagc cccaugugcu gcgacaaagc 1140aucagcuucu ccggcuugcc ucaggccgca gaagcucgcc gccaccucca ggcuuuucug 1200gcccuucccu guccucuugu uccuuuucgc cuuccagcuc cccaccgccc ccuggggauc 1260uuccacuuuc cccuucugcc uucucugcug ccccugggac cccugugacu cgaagagacc 1320cuaaccaggc cuguugcccc uccugccgaa ggucuacuac ccccagcacc aucugggggc 1380ccuugggugg ccuggcucgg agcccaucug cccacucucu gggauccgau ccugaugacu 1440acgccagcag cggcagcagc cugggggggu cagacucacc ugucuuugag gcaggggugu 1500uugggccucc ccagaccccu gcacccccaa ggcgucuccc caucuucaau cguaucucug 1560ucucugagug acaagugccu accuacccag uauggaucag cuagaucuca aagagagggc 1620agggacugcu cauugcugug gggaccuggg gcacuccucu aaguuaauaa gucccaucuu 1680cuggacauuc caagaugcaa uaacccauuu cccuggugcu gggcuggggc aggucccuag 1740uuugcaaauu caguguuugg guggauccgu uccuagggua ccuaagaugu uugagggaga 1800caguugacag uuggucuucc aggccccaag ucuucuguug uuuuugagau aggagcuuau 1860uaugguaccc caggcuggcu uugaacucaa uauaauccug ccuuagccuu uuccaaguuc 1920ugggguuaca gguaugcacc agccccucug caacucuggu cuccuggaau cuuaagugcu 1980gugaagagcc ggcucccaca auacuauccu aauuuuuacu agacccugaa guucaguguc 2040cgguggucga agccucuccu gagaauccug gugcucaaau uucccuccua aagcaaauag 2100ccaaagccau ugccaaaucc cuucuccccc aaccaguggg cccuuuauuu augacgacuu 2160uauuuauugu auuaagauuu uauaguauuu auauauauug ggucgucuac uccguuuuuc 2220uuuuuguaau guuaaaacug auacuguauu aaguauaugc uauaauauau uaauauauug 2280cu 228269364RNAHomo sapiens 69cggacgcugc agaccugacc gacgugcugu gcgaguucga cgcggugcug gccgacuucg 60cgucgcccuu ccacgagcgc acuuccacua ugaggagcac cuagagcgca ugaagcggcg 120cagcagcgcc agcgucagcg acagcagcgg cuucagcgac ucggagagug cagacucagu 180guacagggac agcuucaccu ucagugauga gaagcugaau ucuccaacca acuccucucc 240agcucuccug cccuccgcug ucacuccucg gaaagccaaa uuaggugaca cuaaagagcu 300cgaagacuuc auugccgauc uggacaggac cuuagcaugu augugaagca aggaguuugg 360gguc 36470847RNAHomo sapiens 70ccgggccgag gagaagucug caaaacaaga ggcuggggau ugccuuagcg agaaaucagu 60ucucuuagga gguuagggaa ggaagucuuu cucuggaggu cugagggaag cgcucguguc 120agaugccggg uugucauggg uaagggugac cccaucaagc cgcugggcaa aauguccucu 180uacgccuuuu uugugcagac cugccgggag gagcacaaga agaagcaucc caauucgucg 240gucaacuucg ccgagaucuc caagaaaugc uccaagagau ggaagaccau gucugcaaag 300gaaaacucga aguuugaaga uuuggccaag agcgacaaag cuuguuauua cagggagaug 360aagaacuaug uuucucccaa aggugauaag aaaggaaaga aaaaagaucc aaaugcuccg 420aagagaccac cgucugccuu cugccuguuu ugcucugaaa aucgcccaaa gaucaaaauu 480gaauacccgg gccugucuau uggagauacu gcgaagaaac ugggugagau guggucugag 540cagucugcca aagagaaaca accguaugag cagaaagcag cuaaacuaaa ggagaaguau 600gaaaaggauu uugcugcaua ccgugucaag ggcaaaagug aagcaggaaa gaaggguccu 660gguaggccag caggcucaaa gaagaaugac ucagaagaug aggaagaaga agaggaggaa 720gaugaagagg gggaagaaga ggaugaagaa uaaguggcua uccuaaagug uggaguauau 780gugcucaggc aguuauuuug cuaagaaugu aaauucaagc gcagcucaac auuagcucca 840guaggaa 84771779RNAHomo sapiens 71aucacgcucc uagaacucuu caaaccgauc ucucgucgau cuucaaccgc cgccuccacu 60cgccauggac cccaacugcu ccugugccuc cgguaagggg gacugcugac gggauuucug 120ggagagcuag acaggcuuuu uggccccucc uuuaguaauu acuuuaaggg uacgaccggc 180uaccccuucc gaaugaauuc ugaagcacuc cugcuccuuu aaacuagucc uugagauagu 240ggcucgccua cccgggugau uugccucacc uuccuaggag aacagcguuc agguacuccc 300gggucccacu caaccgcgcu cacugacugc cuucuacuuu uagauggauc cugcuccugc 360gcuggcgccu gcaaaugcaa acaaugcaaa uguacuuccu gcaagaaaag uaaguuggau 420cuucucugcc auuuccccgu cacucuccug gggucccuag cccgccgcgc cgcgccuucc 480cucccgggag cguucaggug gugugccucu gacaagguuu cucgcucacg uucaacucuu 540cucuccccac aggcugcugc uccugcugcc ccgugggcug ugcgaagugc ucccagggcu 600gcaucugcaa agaggcuucc gacaagugca gcugcugugc cugaaggggg gcggaggggu 660ccccacaucu guguaaauag accauguaga agccuagccu uuuuuguaca acccugacuc 720guucuccaua acuuuuucua uaaagcaugu aacugacaau aaaagccguu gacuugauu 779722275RNAHomo sapiens 72gcucugaguu uguggaagau uacaugcgau aucccgcgcg accccgcauc ccuuugccgg 60ccgggacagc cuuugcuaca gccugugaaa cauugcgucc ccgagcccca cgccugaggg 120cgacaugaac ccgcuggcuu cgcgagcagu ccggacccac gaucgcuuuu ggcaaccaga 180accggcgcuu cagcccccgg ggugacgugc agcccgccgc ccagacacau ggccccgagc 240ccaagacccc agcauguccu gcacuggagg gacgcccaca acuucuaucu ccugucccca 300cugaugggcu ugcucagucg ggccuggagc cgccugaggg gcccagaagu cccagaggca 360uggcuggcaa aaacaguaac aggagcagau cagauagaag cugcggcucu gcugacaccu 420accccugucu cugguaaccu ccucccucau ggggagacug aagaaagugg aucuccugaa 480cagagucaag cagcccagag gcucugccuu guggaagcug aaaguucccc uccugaaacu 540uggggacuuu caaauguuga ugaguacaau gcaaagccag gacaagauga ccuuagagag 600aaggaaaugg aacgcacagc uggcaaggcc acacuacagc ccgcuggccu gcaaggggcu 660gauaagaggc uuggggaggu gguggcuaga gaagagggag uggcugagcc cgcuuauccc 720acaucacagc uggagggugg uccagcugag aaugaagagg auggagaaac agugaagacu 780uaccaagcuu cugcugcuuc cauagcuccg ggauacaaac ccagcacccc ugugccuuuc 840uugggggagg cagaacauca agccacggaa gaaaaaggaa cagaaaacaa ggcugacccc 900uccaacucuc cuucuucagg cucccacucc agagccuggg aguacuacuc uagagagaag 960ccuaagcagg agggagaagc caagguagag gcacacaggg cagggcaggg ucacccuugu 1020cggaaugcug aggcugagga aggaggaccu gagacaacuu uugucuguac uggaaaugcc 1080uuccugaagg ccugggugua ucgcccagga gaggacacag aggaagaaga caacagcgau 1140ucggauucag cugaggaaga cacagcucag accggugcca ccccccauac aagugccuuc 1200cugaaggccu ggguguaucg 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ccaucucuuc cacaguccga gccucgcucu 2100uccucugagg ccacucccuu gacccaagau gugaccacac ccucuccccu ucccagugaa 2160accccuucgc ccagccugua cuugggaggg aggcggggcu aagccugagu aguuuccuau 2220uauuuauuua uuuauuuauu ugaauaagaa auaaagccuu uuaauuugua gugau 227573355RNAHomo sapiens 73uuuuuuuuuu uuuuuuuaau caucgagaag uauuuauuga gcaccagcuu uggggucggg 60ugugaggacu cgggacaaug cagggugcug ucccuucucg ugagacgcuu acaaucugag 120uggagacagg gagggagcca caauacaugu ucuuggggug cgggcuaagg guagacaguc 180cagaccagga uguuacagaa acagggaugu uuggggcugg agucagaccc acuaagugcu 240uugacaccca cgguauucaa cacugagaaa ggaucagcca uugcucagug uccugugagc 300ucccuuagcc cccaagacac caucuuggcc uggcuccuug uacaacugcu acuaa 35574289RNAHomo sapiens 74cccaaaaccc auucagcaaa guucccaacc ucgacgggcu agcaguauuu aaccagugau 60ggguucacug uuguauuugg ugaauacugu auuuuguuuc aguucuuucu cccagauaau 120uugaaaacgu uccaggagaa ggcagcuucc uauaugcagc gugugcuuuc uuauucuuuu 180uuuuaauaua ugacaguuau uugagaaccc auuucuacuu ugaauucauu uucguugaaa 240gugauguuuc uucaccuacc auuuuccuau uaaaguucug uauucaaau 289752018RNAHomo sapiens 75agaccgugag cgagagcgcc ccagagaagc gccugcaauc ucugcgccuc cuccgccagc 60accucgagag aaggacaccc gccgccucgg cccucgccuc accgcacucc gggcgcauuu

120gaucccgcug cucgccggcu uguugguucu gugucgccgc gcucgccccg guuccuccug 180cgcgccacaa ugagcuccag caccuucagg acgcucgcug ucgccgucac ccuucuccac 240uugaccagac uggcgcucuc caccugcccc gccgccugcc acugcccucu ggaggcaccc 300aagugcgccc cgggagucgg guugguccgg gacggcugcg gcugcuguaa ggucugcgcu 360aaacaacuca acgaggacug cagcaaaacu cagcccugcg accacaccaa gggguuggaa 420ugcaauuucg gcgccagcuc caccgcucug aaagggaucu gcagagcuca gucagaaggc 480agacccugug aauauaacuc cagaaucuac caaaacgggg aaagcuucca gcccaacugu 540aaacaccagu gcacauguau ugauggcgcc gugggcugca uuccucugug uccccaagaa 600cugucucucc ccaaucuggg cugucccaac ccccggcugg ugaaagucag cgggcagugc 660ugugaagagu ggguuuguga ugaagacagc auuaaggacu cccuggacga ccaggaugac 720cuccucggac ucgaugccuc ggagguggag uuaacgagaa acaaugaguu aaucgcaauu 780ggaaaaggca gcucacugaa gaggcuuccu gucuuuggca ccgaaccgcg aguucuuuuc 840aacccucugc acgcccaugg ccagaaaugc aucguucaga ccacgucuug gucccagugc 900uccaagagcu gcggaacugg caucuccaca cgaguuacca augacaaccc agagugccgc 960cuggugaaag agacccggau 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ugcacauaac 1980gggcagggcg cacugcaagg cugcuucucc cgcauuuagg cugcggcugc aggcaccgcg 2040agcccggagc acccacgagc uuagugugca ggacgcaccc cagcacagcc accuacggcc 2100gcugaaugaa gcuuccagga guccgccccc ggccgucgcc ccgucggagg ugcacccgcu 2160gagagcgccu ggaccgaaag gccggugcgc ucaccugcua accugccagc cauggggcca 2220cacgggaacg acagcgacuu cuugcuggca cccaacggaa gccgagcgcc acaccacgac 2280gucacucagg aacgggacga agcguggguu gugggcaugg ccauccucau gucgguuauc 2340guccuggcca ucguguuugg caacgugcug gucaucacag ccauugccaa guucgagcga 2400cuacaaaccg ucaccaacua cuucauaauc uccuuggcgu gugcugaucu agucaugggc 2460cuagcggugg ugccguuugg ggccagucac accucuauga aaauguggaa uuuuggcaac 2520uucuggugcg aguucuggac uuccauugau guguugugcg ucacagccag caucgagacc 2580cugugcguga uugcagugga ucgcuauguu gcuaucacau cgcccuucaa guaccagagc 2640cugcugacca agaauaaggc ccgagugguc auccugaugg uauggauugu aucuggccuu 2700accuccuuuu ugccuaucca gaugcacugg uaccgugcca cccacaagaa agcuaucgau 2760uguuacaccg aggagacuug cugugacuuc uucacgaacc aggccuacgc caucgcgucc 2820ucgauugugu cuuucuacgu gccccuggug gugauggucu uugucuauuc ccgggucuuc 2880cagguggcca aaaggcagcu gcagaagaua gacaaaucug aaggaagauu ccacgcccaa 2940aaccucagcc agguggagca ggaugggcgg acgggccacg gacuccgaag guccuccaag 3000uucugcuuga aagagcacaa agcccucaag acuuuaggca ucaucauggg cacauucacc 3060cucugcuggc ugcccuucuu cauugucaau aucgugcacg uuaucaggga caaccucauc 3120ccuaaggaag uuuacauucu ccuuaacugg uugggcuacg ucaacucugc cuucaauccu 3180cuuaucuacu gucggagucc agauuucagg auugccuuuc aagagcuucu gugccuucgc 3240aggucuuccu ucgaaaccua ugggaacggc uacucuagca auagcaacgg cagaacggac 3300uacacagggg agccaaacac uugucagcug gggcaggaga gagaacagga acugcugugu 3360gaggaucccc caggcaugga aggcuuugug aacugucaag guacugugcc uagccuuagc 3420guugacuccc aaggaaggaa cuguaguaca aaugacucgc cacuguaaua caggcuuucu 3480acucucuaag accccuccuu gacaggacac uaaccagacu auuuaacuug aguguaauaa 3540cuuuagaaua aaauuguaua gagauuugca gaaggggggg cacauccuuc ucgccuuuuu 3600uuaauuuuua uuuuauuuuu uagcugcaaa caagagagag aacuguauuu gagugcuuau 3660uguucuugua uaguucaguu ccucuuguau ggaacuuaaa gguuucuguc ugaagagugu 3720ugguucugag gacugagucu gucugucugu cugucugucu gucugucugg augauguuuu 3780cauguaucua ccucacuggu caaguauuaa gaaugauaua uauugcugcu ggaaauccau 3840aucuaaagga gagaguuuuc uuccuguacc cuuggacuug aaauauccug ugucuuggac 3900cuuucugcug ugacaauggg cccuuucucu cucacuccac uuauuuacuc aaauggauuc 3960gaggcaggga uuugagggac aacacuaguu guuuuguuuu uguuuuuguu uuuuuguuug 4020uuugguucgu uuuugguuug uuguuguuuu uugggguuug uuuuuguuuu uguuuuuuug 4080gguuuuuuuu uuuugcugag aaaagucuaa aguuuacagu aaauaaauug uuuaaccaug 4140acuucauugc acccguuucu ucaaaaccuc uugacucugg aguguccuug ucucucccac 4200uggaaaccac agguaaacua ugugucguga ccgaugagug gcuuaaugug uaagaguacc 4260agaauggcau gcuugcaugc accgugccua gcccuuccgu gugugucuuc agagcuccag 4320augcaaaccu gugccuuccc uaacuucacu cgugucccaa agcaguccug ccuguucaca 4380gcauaaccca guauguccua caguugcucu ucugugcugu cacuccagaa acccugacuc 4440acggaaacag aguuauggac auauguuuuu guccccauau gcucugacac caccuucagc 4500cuuacuugcu uaauaacugu 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aggauguggg cgccgaggac ccguccaaga 60agaagcggca acgccggcag aggacucauu ucacuagcca gcagcugcag gagcuggaag 120ccacuuucca gagaaaccgc uacccagaca uguccacucg cgaagaaauc gccgugugga 180ccaaccuuac ggaagcccga guccggguuu gguucaagaa ucgccgggcc aaauggagaa 240agcgggaacg caaccagcag gccgagcugu gcaagaaugg cuuugggccg caguucaacg 300ggcucaugca gcccuacgau gacauguacc ccggcuauuc guacaacaau ugggcugcca 360agggccucac gucagcgucu cuguccacca agagcuuccc cuucuucaac uccaugaacg 420ucaauccccu guccucucag aguauguuuu ccccgcccaa cuccaucuca ucuaugagua 480ugucguccag cauggugccc uccgcgguga ccggcguccc gggcuccagc cucaauagcc 540ugaauaacuu gaacaaccug agcagcccgu cgcugaauuc cgcggugccc acgcccgccu 600guccuuacgc gccgccgacu ccuccguacg uuuauaggga cacauguaac ucgagccugg 660ccagccugag acugaaagca aagcagcacu ccagcuucgg cuacgccagc gugcagaacc 720cggccuccaa ccugagugcu ugccaguaug cagucgaccg gccgguguga accgcgccca 780gggcgcgggg auccgaggac ugucggagug ggcaacucug ccccagaaag acugagaauu 840gugcuagaag uucgugcgca cuaugggaag gaagaggggg gaaaaaagau cagaggaaaa 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ugcugagaca gccgcgaccu ugaccacgaa gcacccugac 300uaugccaucc uggcagcaag gauagccguc ucuaacuugc acaaagaaac aaagaaagug 360uucagugaug ugauggagga ucucuacaac uacauaaauc cgcacaacgg cagacacucu 420cccauggugg ccagcucaac acucgacauu guuauggcca auaaggaucg ccugaauucu 480gccauuaucu augaccgaga uuucucuuau aacuacuuug gcuuuaagac acuggaacgg 540ucauauuugu ugaagaucaa ugguaaagug gcugaaagac cacagcauau guugaugagg 600guuucugugg ggauucacaa agaagauauu gaugcugcaa uugaaaccua caaccuacuu 660ucugagaagu gguucacuca ugccccuccu acucucuuca augcugggac caaccgccca 720cagcugucua gcuguuuccu cuugaguaug aaagaugaca gcauugaagg aauuuaugau 780acucugaagc agugugccuu gauuucuaag uccgcugggg gaauuggugu ugcugugagu 840uguauucggg ccacugguag cuacaucgcu gggacuaaug gcaauucuaa uggccuugug 900ccaaugcuga gaguauauaa caacacagcu cgcuaugugg aucaaggugg aaacaagcgc 960ccaggcgcgu uugcuauuua ccuggagccu uggcacuuag acaucuuuga guuccuugac 1020uugaagaaga acacaggcaa ggaagaacag cgagcacgcg aucucuucuu ugcacuuugg 1080aucccagauc ucuucaugaa gcgaguggag acuaaccagg acuggucauu 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1920gaggcuauug ugcgcauugc ugaggcccuc aguaagauga aacugcagcc cuuugccacu 1980gaggcugaug uagaggaggc auugagacug uuccaggugu ccacacugga ugcugcuuug 2040ucuggcaauc ugucgggggu ggagggcuuc acuacccagg aggaccagga gaugcugagc 2100cgcauugaga agcaacucaa gcgccguuuu gccauuggcu cucagguguc ugaacacagc 2160auuguccagg acuucaccaa acagaaauau ccagagcacg cuauccgaaa ggugcugcag 2220cucaugcuac gcagggguga gauccaacac cguaugcagc gcaaggugcu cuaucgccuc 2280aagugagccc auugcccauc aacccucaag ccugaaaugc ugccaccacc cuaucuccca 2340gucagugcuc caaaccuccu uuugcccugc cucuccaccu cagacugcug ucugcagcac 2400aucugcagcc ccuggaaaug uacuuugguc uguuggcuca uacuguguuu gagugucuga 2460ggacucucug cucugggugu cuauccccug ucaugccuuc ucaacaagau gagucuggag 2520caggaacagg cccuggaaug uagauggguc uguauauugg cucccgggcc acucacugcc 2580aagcuucuuu guauguacag agguaauaaa gcaauugagu cccuggcugc uaaggucagu 2640ggacccagu 264993450RNAHomo sapiensmisc_feature(389)..(389)n is a, c, g, or u 93ggaugcagcc ggaagugcag cgugcgugcg guuugguggg ucgcugugug cgcuccgcgu 60gugcagccgc gugggccaug gggcggcggg cgcggggccg gcgguuccag cagccgccgc 120agccugaggg cgaggaagac gccagcgacg gcggcagaaa gcgaggccag gcgggcuggg 180aagguggcua ucccgagauc guaaaggaga acaagcucuu cgagcacuac uaucaggaac 240ucaagaucgu gccagaggga gaaugggacc aauucaugga gucacuccga gaaccucucc 300cagccacacu gagaaucacu ggguacaaaa gccaugccaa agagauucuc cauugcuuga 360agaacaagua cuuuaaggag uuggagganc cugaaguaga uggacagaaa guugaguucc 420acaaccacua agcugguacc cugaagaacu 45094929RNAHomo sapiens 94gagcucaaau ucuggcuuuc uauuggguac gauauauuaa ccaaugggag aaacacaaac 60agaauaccuc caguuaguau aaaugcuugc uguucaguug cagaauuuac uauauauucu 120uuuccuuucu cugcuuugcc uuuacugaua cuuaaacgca uacaugucug gacgcggaaa 180gcaagggugc aaggcccgcg cuaaggccaa gacccgcucc ucccgggccg gccugcaguu 240ccccgugggc cgcgugcacc ggcugcuccg caagggcaac uacucggagc gcgugggcgc 300cggcgccccg guguaccugg cggcugugcu ggaguaccug acggccgaga uccuggagcu 360ggcgggcaau gcggcccgcg acaacaagaa gacgcgcauc aucccgcgcc accugcagcu 420ggccauccgc aacgacgagg agcucaacaa gcugcugggc cgcgugacca ucgcgcaggg 480cggcguccug cccaacaucc aggccgugcu gcugcccaag aagaccgaga gccaccacaa 540ggccaagggg aaguaaucug gcgauugucu guacugccca guugaaaguu aaccaaaaca 600aaggcucuuu ucagagccac ccacaucuuu ccauaaaaug agcugccacc ucgugaaacg 660uucuuccacu acaguuuuua uacuacauau gaaaaaguua cgaaguagcu uucaaucuua 720guaaauugau uuuaauacug uuagucccug cgauaaaucu uacgaccuuc cuuaguuuga 780gucaaaagug uguaagagau gaaaccuuua gaacauacua uaaauuuuua guagaaauuu 840ggcacccagg uuugucauuc acgucacgau ugucuagagc auaaugguag uaagggcuaa 900gggccauuaa aucccacuuc cauaguuuc 92995325RNAHomo sapiens 95uuuuuuuuuu uuuuuuugga aaugaaggua auuuauugaa acugguuuug ggacaggcga 60guggacaacu guugaaagga gcuagcgcac agccgggugg gagcgggugc uuagccacag 120auccuaucug aggcccaacu uuuucuuuuc cuucugcuuc uuacggacca cauccagguu 180ccgguccuuc cacaugcuuu ugcgaagcuu gauggggcgu gagcccacau acuucccauu 240caucucucgc auggcgcgca cauagucacu ggggucuuug aagcugacaa agccauagcc 300cuugguuuug ccugugcgcu uguca 32596367RNAHomo sapiens 96uucggauccu ugccaauaua uguaucccau uuggaauggu gaucuuaaaa ugugagugca 60ugcauacuau cuuauuuaag auacuugcac cccacccacu cccaucuccc gaagcuggaa 120cacugccaac uagguccuua agaaucacgc aauuaacaca agguugggug cugcuaauuc 180uucaugaaaa uccaaacacg uuaagggacc agggagaugc cacugccccc cugaauuuuc 240aucaaaaaua gacacguuua uguaaacaga acuauuuucc auauucauag ugacuuuuua

300aguauuugag ccuaaagauu uugaucucca uuuuuauaac uauuuaaauu guucacaauu 360auuacau 36797418RNAHomo sapiens 97cggccgccgc cgcccccaca cugccccgcg uugacgagcg ccgcgacggc aaggacagcg 60ccucgcuuuu cgugguggcu cggauccuag cggaccucaa ccagcaggcg ccggcgcccg 120cccccgcgga acgcagagaa ggggccgcug cgcgcaaggc gaggaccccc ugccgccugc 180cgccugcgcc cccugcgccg ccacccggcc cagagcccgc cuccccggga caagcaggcg 240cgccggccgc gccccccagc cccgcgugga gcgagccgga ggcggcauug gagcaggagc 300ccggccccgc ggggagcggc gagccuggcc ucagacaaag gggucgggga ggccggagcc 360gcgcggaccu cgaguccccg cagaggaagc acaagugcca cuacgcgggc ugcgagaa 418981552RNAHomo sapiens 98cgucaguccc cgccaccucc ccggccccgc gcgcccggau cggcccuacg gccucgucuc 60gcccggccuu gcgcgccggg accgccgcga ucuccucucc ccgccgcccu ccggcuggcc 120cugccugcug cggcgcgaug aaugacuuug gaaucaagaa cauggaccaa guggccccug 180ucgccaacag uuuucguggg acacucaagc gccagccagc cuuugacacc uucgauggcu 240cucuguuugc ugugcucccu ucucucagug aagaucagac acuccaagaa gugcccacgg 300gccuggauuc ugucucccau gacucggcca gcugcgagcu gccuuugcuc acucccugca 360gcaaggcagu gaugagccaa gccuuaaaag ccaccuucag uggcuuccaa aaggagcaac 420gacgucuugg cauccccaaa aaccccuggc uguggagcga gcagcaggug ugccaguggc 480uucucugggc caccaacgag uucagccugg ugaaugugaa ccugcaccag uuuggcauga 540acggccagau gcuguguaac cucggcaagg agcgcuuccu ggagcuggcg ccugacuuug 600ugggugacau ccucugggaa caucuagagc agaugaucaa agagaaccaa gaaaagacag 660aagaccaaua ugaggaaaac ucucaccuca acgcgguucc ucauuggauc aacagcaaua 720cauuaggcuu cagcauggaa caggcuccau auggaaugca ggcaccaaac uaccccaaag 780acaaucuccu ggacagcaug ugcccgccau cggccacgcc ugcagcucug ggcucugagc 840uccagauguu gcccaagucu cggcucaaca ccgucaaugu caauuacugu uccaucagcc 900aggacuuccc cagcagcaac gugaauuugc ucaacaacaa uucuggaaaa cccaaggacc 960acgacucucc agagaacggu ggggacagcu ucgagagcuc cgacucgcug cugagguccu 1020ggaacagcca gucgucccua cuggauguac agcggguacc uuccuucgag agcuuugagg 1080aggacuguag ccagucucug ugccucagua agcugaccau guccuucaag gacuacaucc 1140aagagaggag cgacccaguc gagcaaggca aaccaguuau uccugcagca guacuggcug 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480acuacaacca gagcaagggc ggugagugac cccgggucgg aggucacuac cucuccacgu 540cccgaaacag aggccgguga ggucccgggu gcaaaguccg agguucagga gcagaacuga 600cccaggacug gauucccuuu caguuuggag gaguccgcgg ugggggggug gggggggggc 660ggaggaggga cugaccacug ggucccgcag gcucucacac acuccagugg auguauggcu 720gugacauggg guccgacggg cgccuccucc gcggguaccu gcaguucgcc uaugaaggcc 780gcgauuacau cgcccugaac gaagaccuga aaacguggac ggcggcggac auggaggcac 840agaucacccg acgcaagugg gagcaggcug guauugcaga gagagaccgg gccuaccugg 900aggucgcgug aggcuccgca gauaccugca gcucgggaag gagacgcugc ugcgcacagg 960ugcaggggcc gcgggcagcu ccucccucug cccucaggcu ggggcucagu ccuggggaag 1020aagaaacccu cagcuggggu ggugccccug gcucagaggg gagagaguga cccugggucu 1080ccugaucccu caucacagug acugcacuga cucucccagg gcucagccuu cucccuggac 1140agugcccagg cugucucagg agggaaggag agaauuuccc ugagguaaca acagcugcuc 1200ccuucaguuc cccuguagcc ucugucagcc auggccucuc ccaggccagg guucucagcc 1260uacacccacu gucuguagac acugacuccu guccugcuga gugugucagc ccuuacaccu 1320caugaccuga agucuccuuu 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gaccacagug guuuagucuc aaugguguca 2220cucuuccagu agcauauggu ccugauuucu aauuuagaua cgaacucaaa cacauaugaa 2280auuucuuauu uuccauucca ucuuccauua uauagcuacc uaucucgugc uauugaacau 2340cacauaagga ugaccauguu gacccacugg cucaugugga uucccucuua gcuucugagu 2400ccccucagga aaaugugcag uccugugcug agggggccag cucugccugc aggucacuag 2460ugccaugaca guuaaagugu ucauacagac acauaguuca uuguaauuac ugauuuagcg 2520uugucuuggc aguuuucagu uugcaugcau uuauuuauuu auuuauuuau uuauuuauuu 2580auuuaaugca uggaaguaca cuguugcugu acugaugguu guuugccuuu gugugguugu 2640ugggaauuga auuuuuuuuu uuaggaccuc ucuuugcucu ggucgacccu gcucacuccg 2700gucaacuccu augggucaac ucugcucauu cagucccugc uuguucuggc ccaaagauuu 2760auuuauuauu uauuauacau aaauacacug uagcugacuu cagaugcacc agaagagggc 2820gucagaucuc auuacagaug guugugagcc accauguggu ugcuggaguu ugaacucagg 2880accuucaaaa gagcagucag ugcucuuacc cucugagcca ucuccccagu ccucaguuug 2940ucuucuuaau ugugcgauuu cuugaaucuu ccaaacagau cccccaaaga cacaugugac 3000ccaucacccc auaucuuaug augcugucac ccugaggugc ugggcccugg gcuucuaccc 3060uguugacauc acccugacuu ggcaguugaa uggggaggag cugacccagg acacggagcu 3120uguggagacc aggccugcag gggauggaac cuuccagaag ugggcagcug ugauggugcc 3180uuuuggggag gagcagaauu acacaugcca ugugcaccau gaggggcugc cugagccccu 3240cacccugaga ugggguaagg aggguguggg ugcagagcug uggucaggga aagcuggagc 3300auucugcaga cucugagcug gucagggcug agagcuggga ucaugacccu caccuucauu 3360uccuguaccu guccuuccca gagccuccuc cauacacugu cuccaacaug gcgaccauug 3420cuauuguggu ugaccuugga gcuguggcca ucauuggagc ugugguggcu uuugugauga 3480auaggaggug aaacacaggu aggaaagggc agggucugag uucucucuca gucuccuuua 3540gaagugugcu cuaaucauua augggaaacc caucuacacc ccacauugcu accuucucca 3600acuggguccu cugucaguuc ugggaacuuc caagaucuuc cuugaacucu cacagcuuuc 3660cuucucacag guggacaagg aggggacugu gcuccagcuc cagguuagug uggggacagg 3720auuguccugu ggacauugca gugaagcugg agauguuggg gagcucuggg aacccauagu 3780aacucuucca gagaaaucuu ccagggccgc aguuguccaa uaugaauaca uauauguaca 3840uaugcauaua cauuuuuuac ccuuggcagg gacagcuccu agagcucuga 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gggauuugga cuggggcccc gagcagcauc 480ugacucuggu ggucgcgacc gaggauccug cacguucugu guggucgggg aaccuaugua 540cccgguggcc aaggggacga gcgcagcggg aagcgcgaau aucugcgaau uccccuucuc 600gcucgcccgu aucucccuag cugacugucu uucugccccu ccgucuccgu uacggucuua 660cauuuccucc uaucugcccc uaauacgcug ucccucuaaa uaccugcccc aucccugccu 720ggacaggauc agagguguuc uccaucucca guuaauaacu gggaccuggg gucugggcac 780auagagacgg gguccaucag aacucagccg ggacagagaa uucuuagcag ccuguccgag 840gcuguccgug uguugcucug guuguccgug ucccuuuauc cggucaaguc cucaucucuu 900ugugcgcagu auagagccca ugggccccag gcagugguuc cgagggguuc cuggagacca 960cgaaguguug ggaugugcgc ggggucaccu gcccggccac acucgcgcuc cacauucucg 1020gcacccgacg ucucucacug cuggauaggg gcacuugaga gguugcaggu guccauuucc 1080ugucgagggg ccgcgagcac gugucgccag gggagggaag gagcugcguc cguuucgccg 1140agucacagcg ggccgaguca cugaggcuga gucacccugg gugccccucc cuuccuggcc 1200ccaaacggcc ccuaaggacc gacgaccugg gagcgagaga ugccccuggc agugcuucua 1260gcccagaacg ggggucacug agaugcuggg ucccccagua uugggcuggg 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gaagucauuu 2340ucucuggcug agugucagag guugacacca uuucugcuac acacucugug auggcugcuc 2400acuuggacug gcgguuaugc uaguuagcaa gaugaacaca gugguuuacg ucucaguugu 2460cacacccuuc caguggcaua uggcucuaau uucuacuuuu gauacgaacu caaacacuua 2520uuaaauuagu uaguuuccau uccaucuucc auucuagucc auucaugcua aagaacauca 2580cauaaggacu gccaggauga cccacuggcu cauguggauu cccucuuagc uucugagucc 2640cccagaaaaa ugugcagcug aggaaaccag cucugccugc aggucaccag ugccaugaca 2700guugaagugu caaacagaca cauuguucag ugucaucagu gauuuaacug ugccuugugu 2760agauuucaga gggucuuguu aauuguggua cuuuuuuuug uuuuuuguuu uuuuuuuuuu 2820uuguuuuguu uucaagacag gauuuuucug uauagcccug gcuguccugg aacucacauu 2880guggaccagg cugaccacga acucagaaau cugccugccu cugccucccg agugcuggga 2940uuaaaggcgu gugccaccac caaccagcua aucgugagau uucuuucuuu uuucuuuucu 3000uuucuucuuu uuuuuuuuuu uuuuguuguu guuguuuugu uuuuugagac aggguucucu 3060guguaucccu ggcuguccuu gaacucacuu uguagaccag gcuggccuug aacuuagaaa 3120uuugccugcc ucugcuccgg agugcuggga uuaaaggcau gugccacuac caaccagcua 3180auugugggau uucuuaaauc uuccacacag auccuccaaa ggcacaugug acaugucacc 3240acagaucuga cggugauguc acccugaggu gcugggcccu gggcuucuac ccugcuaaca 3300ucauccugac cuggcaguug aauggggagg agcugaccca ggacauggag cuuguggaga 3360ccaggccuuc aggggaugga accuuccaga agugggcauc ugugguggug ccucuuggga 3420aggagcagaa uuacacaugc caugugcacc augaggggcu gccugagccc cucacccuga 3480gaugggguaa ggagggugug ggugcagagc uggggucagg gaaagcugga gccuuuugca 3540gacccugagc ugcucagggc ugagagcugg ggucaugacc ucaccuucau uuccuguacc 3600uguccuuccc agagccuccu ccauccacug ucuccaacau ggcgaacgua gcuguucugg 3660uuguccuugg agcuuggcca ucauugcagc ugugguggcu uuugugauga agagaaggag 3720acacacaggu aggaaagggc agagucugag uuuucucuca gccuccuuua gagugugcuc 3780ugcucaucaa uggggaacac aggcacaccc cacauugcua cugucuguaa cugugucugc 3840ucucaguucu gggaacuucc uagugucaag cucuuccuug aacucucaca gcuuuccuuc 3900ucacaggugg acaaggaggg gacuaugcuc uggcuccagg uuaguguggg ggacagaguu 3960guccugaggu cauuggagug aagcuggagu uguugggugc ucugggaacc cauaauagcu 4020ucucuguugu aauccucugg uggccugugu cagaucuugc uauagauaua ucuuuguaua 4080uauuuuuccc uaggcaggga cagcucccag agcucugaua uguuucucuc aagauuguaa 4140aggugacauu cuauggccug auugcagagg ggcacugugg acaugguugu guuucaggga 4200cucccacaau ccccugugag ugguggguug uugggauauu gucuucauug uggugguucc 4260ugacccucau ucucuaucau gaagacagcu gccuggagug gacuuaguga cagccagugu 4320gaccuugggu cuucauuuuu cuuuagagaa cagcgccuga uguucccugu gagccuaugg 4380gcucaaugug aagaauugug gagcccagcc uucgccuaca caccaggacc ugucucuugc 4440auugcccugu guucccuucc accgccaacc uuccgggucu gcag 4484108385RNAHomo sapiens 108uuuuuuuuuu uuuuuuucag aauaauugca gacaaauucc auuuauuuuu cuaaaaaccu 60cauuaucuaa aauuuauaca gccucacauu ccuaaaccac cucuggcacu uuucuugaau 120uaagucaagg cguacacagc uccgaaagaa aaauagagau ccgguuccag gaagauggcc 180augaggacuc gcagauaugu cuccucggac cuggaagcgu gucagccaug ggauccacua 240auccaccauc cgguacacag ggucacccac ucucaggcuc ccaagcuucu ccaccgagaa 300auacauccca aaaaguggag augacuggua uauacucuuc acagaaggau cacacaggcg 360auagcucuuc agggucucca guggc 3851092247RNAHomo sapiens 109cucuagauga auacacucuc augagggcca ccuucucugg uaguucaggu cgccucugcc 60cauccuuccc ugcguccucu cccaaagugg ccuacaaccc uuacccagag gacuauggag 120acauugagau ugguucucac aagaguucca gcaguaaccu gggggcagau gauggcuaca 180ugcccaugac cccuggggca gcccuuagga gugguggucc caauagcugc aagagcgaug 240acuacaugcc caugagcccc acaagcgugu cugcucccaa gcagauccug cagccacgcu 300uggcagcggc cuugcccccu uccggagcag ccgugccagc acccccuuca ggggugggca 360ggaccuuccc aguaaacgga gguggcuaca aagccagcuc cccagcggag agcuccccag 420aagacagugg guacaugcga auguggugug gcuccaagcu gucuauggag aacccagacc 480cuaagcuacu ccccaacggg gacuaccuca acaugucccc cagcgaggca ggcacugcag 540ggaccccacc ugacuucuca gcagcuuugc guggaggcag ugaaggccuc aaaggcaucc 600cgggccacug cuacagcucu uugccccgcu cuuauaaggc ucccuguucc ugcagcggag 660acaaugacca guaugugcuc augagcuccc cugugggccg gaucuuggaa gaggagagac 720uggagcccca ggccacccca ggggcuggca ccuuuggggc agcugguggu agucauaccc 780agccucauca cucagcagug ccuuccucca ugaggccgag ugccaucggu ggccgcccug 840agggcuuccu gggccagcga ugucgggcag ugcggccuac acgccuaucg cuagagggac 900ugcagacccu ucccagcaug caagaguacc cucuacccac agagcccaag agcccuggcg 960aguacaucaa cauugacuuu ggugaggcag guacccgucu gucuccgccu gcccccccac 1020uacuggcauc cgcggccuca ucuucuucac ugcucucagc uaguaguccu gcuucauccc 1080uggguucagg aaccccaggc accagcagcg acagccggca gcgcucucca cucucugacu 1140auaugaaccu ggacuucagu ucucccaagu cccccaagcc uagcacccgc aguggggaca 1200caguaggcuc cauggauggc cuucucucuc cagaggcuuc auccccauac ccaccacugc 1260ccccacgucc uuccacuucc ccuuccuccu uacagcagcc ucugccaccu gccccgggag 1320accuauaccg ccugccucca gcaucagcug ccacuuccca gggucccacu gcuggcuccu 1380caauguccuc cgagccuggg gauaauggug acuauaccga gauggccuuu gguguggcug 1440caaccccgcc acaaccuauc guggcaccuc caaagccaga aggugcccga guggccaguc 1500ccacaucggg cuugaagcgg cuaagucuca uggaucaggu aucuggggug gaggcuuucc 1560uucaagucag ccagcccccu gacccccacc ggggugcuaa ggucauccgu gcagacccac 1620aggggggacg ucgucgccac aguucagaga ccuuuuccuc uaccaccacc gucaccccag 1680uguccccauc cuuugcccac aauuccaagc gccacaauuc ggccucugug gaaaaugucu 1740cacucaggaa aagcagugaa ggcagcagua cccugggagg aggugaugag ccgcccacau 1800ccccaggaca ggcacagccc uugguggcug ugcccccagu gccacaggcu aggccgugga 1860accccgguca gcccggagcu uugauuggcu guccuggagg cagcaguucu cccaugcgca 1920gagagaccuc cguggguuuc cagaacggcc ucaacuauau cgccaucgau gugagaggcg 1980agcagggguc cuuggcgcag ucucagccgc agccaggaga caagaacucc uggagccgga 2040cccguagccu uggggggcuc cucggcaccg ucggaggcuc uggcgccagc ggagugugug 2100gggguccagg cacuggagcu uugcccucug ccagcaccua ugcaagcauc gacuuccugu 2160cccaucacuu gaaggaagcc acagucguga aaggugaggc ccuuugaccu ugaggauggg 2220ggagggagag uggaguauug gguggcu 2247110315RNAHomo sapiens 110uuuuuuuuuu uuuuuuucag cugugaacua uuggauuuga gacaggaaca gaacaaaucg 60acgggccaga ggagggugga gagagcacga gugguuuaaa uaggggagga ugggagcaug 120gcgguggggg ugggggaaga guuauuuaca agaaggcuca gggggccaga ggcucaucuu 180ggaauauuuu auaacaauau auauaagauu cugguuugcu uuuccuuuuc gucucguaaa 240ggagagagaa uugcauaguu cgauucuguc caagggggca gcugcauaug gucggccggg 300cgggucacug gucgu 315111481RNAHomo sapiens 111uuuuuuuuuu uuuuuuuaag ugucaccacu ugugacaguc agcauguuac uaucagcucc 60agccgcagcg uuuuuaaggc guuauagauu aggcaggcaa uacaaggaac acgauuaaga 120aacugacacg uaccacacga gcaauuucca gaggcuccuc uucugcggug cacacguaac 180agugcucuug uugacauuca gacaguucug agggccacuc ugagaggcgc cuuccuguuc 240ucaccugaca aggauauugu uugguuuggu uugguuuggu uuugccuuac uauggcuuuu 300cuuucaacua cauuuugugu caugcuuguu agcuaacuca aauuuugucu uuguauauuu 360acuacuguaa aauuagaaua auuuacuguu caucucaucc ucugucacug auggaaccua 420gagacgccac aagagccacu gccgugacau accucacaag cuacaucccu guccucaaaa 480u 481112379RNAHomo sapiens 112cggccgcggc caccggccug cgccaagcug cugcugcggc agccaguacc ucggugaagc 60ccauuuucag ucgcgaccug aacgaggcca agcggagggu gcgcgagcuc uaccgcgcuu 120gguaucggga gcgugccgaa caccgugcac uuaaugcagc uggauaucac ggugaaacaa 180ggacgggaua aaguccgaga aauguucaug aagaaugccc augucacaga ccccagagug 240guugaucugc uggucauuaa gggaaagaug gagcuccagg aaaccaucaa aguauggaag 300cagcggacac acguuaugcg guuuuuccau gaaacagaaa caccaaggcc aaaggauuuc 360uuauccaagu ucuauaugg 3791133733RNAHomo sapiens 113gcaccugagc gcgggugccu

ggcgcgcccg augggaucgu ugagaggccc ucgacggaaa 60gucccaaacu cggaucgcau ucagccaaag ugaggcggcg ccauggagcu ccgagcgcug 120cugugcuggg cuucccucgc cacugcuuua gaagagaccc uguugaacac aaaacuggaa 180acggcggauc ugaaaugggu gacuuacccu caggcagagg gccaguggga ggagcuaagc 240ggccuggaug aggaacagca cagcguccgc accuaugagg ugugcgacau gaagcgucca 300gggggccagg cucacuggcu gcgcacuggc ugggucccaa ggcgaggugc uguccacgug 360uaugccacga uacgcuucac caugauggaa ugccuguccc ugccgagggc cagucgcucc 420ugcaaggaga cauucacugu cuucuauuac gagagcgaac gugauacggc cacggcccau 480acgcccgccu ggauggagaa ccccuacauc aagguggaca caguggccgc agaacaucug 540acucggaagc gcccuggagc ugaagccaca gggaaaguua auaucaagac gcugcgccug 600gguccucuca gcaaagcugg cuucuaccug gcuuuccagg accaaggagc cugcauggcu 660cugcucuccc ugcaucucuu uuacaagaag ugcuccuggc ugaucacgaa cuugaccuac 720uuccccgaga cggugccucg ggagcucgug gugccggugg cagguagcug cguggccaac 780gcggucccua ccgccaaccc cagccccagc cucuacugcc gggaagaugg ucaaugggcu 840gagcagcagg ucacgggcug cagcugcgcg ccaggguacg aggcugcgga aagcaacaaa 900guaugcagag ccuguggcca gggaaccuuc aagccccaaa uaggagacga guccugccug 960ccgugcccag ccaacagcca cucgaauaac auugggucuc cugucugccu gugucgaauu 1020ggguauuacc gggcccgcuc agacccccgg aguucaccuu gcacuacccc acccucugcu 1080ccaagaagcg ugguucacca uuugaauggu uccacccugc gccuggagug gagugcuccc 1140cuugaguccg gaaggccgag agaccucacu uaugcuguuc gcugccgaga gugccguccu 1200ggggguuccu gcuugcccug ugggggcgac augaccuucg accccggucc ucgagaccug 1260guugagcgcu ggguggcaau ccgagggcug cguccugaug ucaccuauac cuuugagguu 1320gcugcuuuga augguguguc uaccuuagcc acuggaccac cuccuuuuga gccugucaau 1380gucaccacug accgugaggu gccuccugca gugucugaca uccgagugac ucggucguca 1440cccagcagcu ugauccuguc augggcuauc cccagagcac ccaguggggc cgugcuggac 1500uacgagguca aguaucauga gaagggcgca gagggcccca gcaguguucg uuuccugaag 1560acaucagaaa accgagcuga gcuccggggg cugaagcggg gagccagcua ucugguccag 1620guacgcgcac gguccgaggc uggcuacggu cccuucggcc aggagcauca cagucagacu 1680caacuggaug agagcgagag cuggcgggag cagcuggccc ugauugcagg cacugcgguu 1740gugggugugg uccugguccu gguggucguc aucauugcag uucucugccu caggaagcag 1800agcaauggga gggaaguuga guacucggau aagcaugggc aguaucucau cgggcacggu 1860accaaggucu acauugaucc uuuuacuuac gaagacccua augaggcagu gagggaauuu 1920gccaaagaga ucgaugucuc cuaugucaag auugaagagg uaauuggugc aggugaguuc 1980ggcgaggugu gccggggucg gcugaaggca ccagggaaaa aggagagcug uguggccauc 2040aagacucuga aggguggcua caccgagcgc cagagggcug aguuccugag cgaggccucc 2100aucaugggcc aguucgagca ucccaacauc auccgccucg agggcguggu caccaacagu 2160gugccgguua ugauccucac ggaauucaug gagaacggag cccuggacuc cuuccugcgg 2220cugaacgacg ggcaguucac agucauccag cuggugggca ugcugagggg caucgccucg 2280ggcaugcggu accuggcuga aaugagcuau guccaccgag accuggcugc ucggaacauc 2340uuggucaaca guaaccuggu cugcaaggug uccgacuuug gccucuccag auucuuggag 2400gagaacuccu cugaucccac cuacacaagu ucccugggag gcaagauucc cauccgaugg 2460accgccccug aagccauugc cuucaggaag uucaccucug ccagugaugc cuggcgcuau 2520gggaucguca ugugggaggu caugucuuuu ggggaacggc cauacuggga caugagcaac 2580caggauguga ucaaugccau ugaacaggac uaccggcugc cuccuccucc agacugcccc 2640accucccucc accagcucau gcuggacugu uggcagaagg accggaaugc ccggccccgc 2700uuuccccagg uggucagcgc ucuggacaag augauccgga aucccgcuag ccucaaaauc 2760guggccaggg agaauggcgg ggccucacau ccacucuugg accaacggca gccucacuac 2820ucugcuuucg guucuguggu cgaguggcuu cgagccauca agaugggaag auacgaggaa 2880aguuuugcag cggcuggauu cggcuccuuu gagaugguca gucagaucuc ugccgaggac 2940cuucuccgaa uuggagucac ucuggcagga caccagaaga aaaucuuggc cagugugcag 3000cauaugaagu gggaagcuaa gccaggagcc ccugguggga cagggggacc agcccagcag 3060uucugaccuc caaggacuca ccaccguggc agauucuucu uuccgggagg cagaguuggg 3120uggggacuca caagaugagc cccucccccu cgucacagcc uucccauugg auugcacuuu 3180gaacagaggg ggucggagac acagauuugg ggaaccgugc cauaugggau cauacaugug 3240cccuccaggc ggggaacccc aaacucagag ugagucuuuc ccucaagacu gggcaaagaa 3300acaucccuac gucucuaacc ucccaucuuc ccagaggcuc ucuccccaag cgccuuccac 3360cucaacgggc augucccugc agaccaaaga gaaaggguga ccagccugcc aacuugggag 3420uggaaaaugc cgucccagga ggcaggaagg ggcugucagg acccggugau guaaucauug 3480gguuuugaug uccugacuug cugucaccac caaaggcaau cauuuuuccc uuguaaaugc 3540cccuccccuc aucugccuuc auauugaagg uucugaaguu uuacuguuuu uuauuuuguu 3600aauuuuuucc uccuuccccc cucccucccc uucuugucca gauuuugugu guuaaagggc 3660accugguucc acuaucuccu guugggaaca aggacccauc gauauguucu agaacagugc 3720cuuggaaaug cca 3733114560RNAHomo sapiensmisc_feature(107)..(107)n is a, c, g, or u 114ggcagcgaga cgagcucacg gucgaggaua cgggugaagc gggacaggag caggagccgg 60agccgggcca aagcagaagg ugcaggucgg cgccggcggu ugggcangac ccagucaagc 120cggacaguga ggagcggaug cagacggcac gaccauggcc acgauggugc uuccucgaga 180ggagaagcug agucaggacg agauagugcu gggcaccaag gcggugaucc aggguuuaga 240gacccugaga ggggagcauc gugcccugcu agcuccccua gcuucucaug aagcaggcga 300ggcugagcgg gcucacagga gcgcugccuc cuccugcgcc gcucccugga ggccaucgag 360cuggggcuug gggaggcuca ggugauccug gcauuaucaa gccaucuggg ggcuguggag 420ucagagaagc agaagcugcg ggcucaggug cggcccuggu acaagagaac agugguugcg 480ugaggagcug gcagggacac agcagaagcu cagcgcagug aacaggcggu ggcucagcug 540gagaagagag cagcacaucu 560115560RNAHomo sapiensmisc_feature(107)..(107)n is a, c, g, or u 115ggcagcgaga cgagcucacg gucgaggaua cgggugaagc gggacaggag caggagccgg 60agccgggcca aagcagaagg ugcaggucgg cgccggcggu ugggcangac ccagucaagc 120cggacaguga ggagcggaug cagacggcac gaccauggcc acgauggugc uuccucgaga 180ggagaagcug agucaggacg agauagugcu gggcaccaag gcggugaucc aggguuuaga 240gacccugaga ggggagcauc gugcccugcu agcuccccua gcuucucaug aagcaggcga 300ggcugagcgg gcucacagga gcgcugccuc cuccugcgcc gcucccugga ggccaucgag 360cuggggcuug gggaggcuca ggugauccug gcauuaucaa gccaucuggg ggcuguggag 420ucagagaagc agaagcugcg ggcucaggug cggcccuggu acaagagaac agugguugcg 480ugaggagcug gcagggacac agcagaagcu cagcgcagug aacaggcggu ggcucagcug 540gagaagagag cagcacaucu 5601161649RNAHomo sapiens 116augaugugug gcgcgccauc ugccacaaug ccagccacgg ccgagacgca ggaggucgcc 60gaccagguga ggcugggccc aggucaggcc agucugagcc aggccugcgg agacccggcg 120gccucaggga ccggccugcc cagacugguc agguccugca gcggguuucc ggggcggcca 180caagugugac ugggagcugg gggcucugga ucugguugga agauucaggg ccgggaacug 240gggcgagucu ucugccgcuu gcauacaaga gggccacuca ccuauuaggg aacuagcccc 300gggaucggug gagggauccg guggucccag agaauucagg aaggcagugu uagaaccuag 360acggcaccuu uuugacuuac acccaggccu aaacaagaga aagccagacu gggcuacugu 420gcuugucucc ucaaaagaaa gagcuaggac uguuuagcuc aguggcagga auucaacuga 480uaccaccacc accaucacca acaccgcccc ucagggaaaa aaaaaaggau caaaaccaga 540aguuguagaa cuugcuugug ccuagucuga aacgaggggg uggaccuugg gccugggcug 600cccuuccugu gacuguuagc agagcagaga uucaguacaa gguaggggga gguucagggu 660auuagcaaga gaagaaaagu uaaacaaauc cucucuucag cucuccugcc acgccccaag 720cccaggaccc uguccacuaa gccuagcuga ucuugggagg uguuugcucu gaacugaagu 780ggccaagaag gaagugaguc agcuccauga gacccuagaa augaggaaau guuacagaca 840cacuggccag gcaagggaac cuuggccacg ugccacauca gcacucagga ggcagagaca 900ggcgagucuc ucugaauuug aagccagccc aguuugcuua guuccaugcc agccauagcu 960acauagugag acccuguccc cccccccccc aaaaaaaagg agcuguguug uucuuuauca 1020guggggccaa caguuuacca ugucccccgg aaugaggagu auugaaggcu ggcagugugu 1080gugugugggg gcaccugugc augaaucuaa guccuuccuu cucacccacc auccagguga 1140agucccagcu ugaaucgaaa gaaaaucaga aguuugaugu cuuuaaagcc auauccuuca 1200agagacagau aguggcuggc accaaccucu ucaucaaggu ggguacugau aguagcuugc 1260caugaacugg ggacauaguc ucagaguaga gcagaguguc cugcaacuuc cugcagagaa 1320ccccuuaagg ggacauguac auguucugag aggaugaauu ugggguguua ggguucccgg 1380ccuuaaagga ggagacaagg guuaucacug gcuaaguuag uggcuggugg ccuguucugg 1440cucaguuucu aaggcugggu uaagccugga acuggaaccu uaccuuucac ucacaugucu 1500gucugucugu cuuccuccag guugauguug guggagauaa augcgugcac uugagggugu 1560uucaaccccu cccccaugaa aacaagccuu ugacccuguc uuccuaucag accaacaaag 1620aaaggcacga ugagcucucc uacuucuga 1649117334RNAHomo sapiens 117gaaaauguua agagccauca aauuucugga uauuuugcua ggaaaaugaa auucuacacu 60uauuuuuugu agacuuuuuu uaaaugcugu uuacaugaau uguauuuugg aaaaaauauu 120auacugugca cccugugaug caugaaguga uuuuauguau ggucugcuau gugggcagag 180gucaccuuau uccuaugauc uggaauuguu uacuuucuac 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acaaaaggau aauucucuaa 240uuaucaaguc agccaucagc uuuucuuagg agagagagag agagugugug ugugugugug 300ugugugugug uguguguguc ugucugucug ucugucuggg uaucccacuu agggccaugu 360gcauguuagg uaaaugcucc accacugagc uguuucuuag ccgcacuuuu cucagauuuc 420agguuuguuu guuuguuugu uuguuuuuua acuaggcaug aaaauaaacu ucacuucaaa 480u 481120302RNAHomo sapiens 120uuuuuuuuuu uuuuuuugug gaaauuacuc uuuauugaaa aauaccagua auacugacag 60acuucaaaau caauuuacgg uuccagaaua caaaguacuu aauacauuuu uuuccaaacc 120uguuuguauc ucaaaguuag cauuuuugua aaucaagaua caaauaugau aacuucacua 180aaauauuuuc cagcuuuauu cuuuaaggag cuguauaacc uucaaaguca gggucccgag 240gucagcaggg cauggggcag aaugcaccug gcacucccug ugcagcagac ugcaaccaca 300uu 3021211266RNAHomo sapiens 121auggccagcu uucccccgag gguuaacgag aaagagaucg ugagaucacg uacuauaggg 60gaacucuugg cuccagcagc uccuuuugac aagaaaugug guggugagaa cuggacgguu 120gcuuuugcuc cugaugguuc cuacuuugcg uggucacaag gauaucgcau agugaagcuu 180gucccguggu cccagugccg uaagaacuuu cuuuugcaug guuccaaaaa uguuaccaau 240ucaagcuguc 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guguguauuu uugggccacu 1140ccaaggcaag ucccuagccu ucaacauaua ugucgcaugu caauccgaag agugaugucc 1200acccaagaag uccaaaaacu gccuguuccu uccaaaauau uggcguuucu cuccuaccgc 1260gguuag 12661221266RNAHomo sapiens 122auggccagcu uucccccgag gguuaacgag aaagagaucg ugagaucacg uacuauaggg 60gaacucuugg cuccagcagc uccuuuugac aagaaaugug guggugagaa cuggacgguu 120gcuuuugcuc cugaugguuc cuacuuugcg uggucacaag gauaucgcau agugaagcuu 180gucccguggu cccagugccg uaagaacuuu cuuuugcaug guuccaaaaa uguuaccaau 240ucaagcuguc uaaaauuggc aagacaaaac aguaauggug gucagaaaaa caagccuccu 300gagcacguua uagacugugg agacauaguc uggagucuug cuuuuggguc uucaguucca 360gaaaaacaga gucguugcgu uaauauagaa uggcaucggu uccgauuugg acaggaucag 420cuacuccuug ccacaggauu aaacaauggu cgcaucaaaa ucugggaugu auauacagga 480aaacuccucc uuaauuuggu agaccacauu gaaaugguua gagauuuaac uuuugcucca 540gaugggagcu uacuccuugu aucagcuuca agagacaaaa cucuaagagu gugggaccug 600aaagaugaug gaaacauggu gaaaguauug cgggcacauc agaauugggu guacaguugu 660gcauucucuc ccgacuguuc uaugcugugu ucaguuggcg ccaguaaagc aguuuuccuu 720uggaauaugg auaaauacac caugauuagg aagcuggaag gucaucacca ugauguugua 780gcuugugacu uuucuccuga uggagcauug cuagcuacug cauccuauga cacucgugug 840uaugucuggg auccacacaa uggagaccuu cugauggagu uugggcaccu guuucccucg 900cccacuccaa uauuugcugg aggagcaaau gaccgauggg ugagagcugu gucuuucagu 960caugauggac ugcauguugc cagccuugcu gaugauaaaa uggugagguu cuggagaauc 1020gaugaggauu guccgguaca aguugcaccu uugagcaaug gucuuugcug ugccuuuucu 1080acugauggca guguuuuagc ugcugggaca caugauggaa guguguauuu uugggccacu 1140ccaaggcaag ucccuagccu ucaacauaua ugucgcaugu caauccgaag agugaugucc 1200acccaagaag uccaaaaacu gccuguuccu uccaaaauau uggcguuucu cuccuaccgc 1260gguuag 12661231287RNAHomo sapiens 123gaauuccgug ugcaaggcga ggucuguaag cuggagcggg gcagaggcug gcgggcaccc 60cuuccugacc gcuggugccg ccgccgccgc cuucgggagg aucagacaug gcccagaacu 120ugaaggacuu agcuggacgc cugcccgccg ggccucgggg caugggcacg gcgcugaagc 180ugcugcuggg ggccggggcg guggccuacg gcguccgcga auccguguuc accguggaag 240gcggucauag agccaucuuu uuuaaucgua uugguggcgu gcagcaggac acgauccugg 300ccgaauuuca cuucaggauc cccugguucc aguaccccau caucuaugac auucgggcca 360gaccucggaa aaucuccucc cccacaggcu ccaaagaccu gcagauggug aacaucuccc 420ugcgugugcu gucccgaccc aaugcccagg agcuccccag cauguaccag cgucuagggc 480uggacuauga ggagcgagug cugccgucca uuguuaauga ggugcucaag aguguggugg 540ccaaguucaa ugccucgcag cugaucaccc agcgggcuca ggugucccug uugauccgaa 600gagagcugac agagcgcgcc aaggacuuca gccucauccu ggaugaugua gcuaucacag 660agcugagcuu cagccgagag uacacagcug cuguagaagc caagcaagug gcccagcagg 720aagcccagcg ggcccaguuu uugguggaga aagcgaagca ggaacagcga cagaagauug 780ugcaggcuga gggggaggcg gaggcugcca agaugcuugg agaagcacug agcaagaauc 840cuggcuauau caagcuccga aagauccggg ccgcccagaa caucucuaaa acgaucgcca 900caucacagaa ccgaaucuau cucacagcug acaaccuugu gcugaaucua caggaugaaa 960guuuuacucg gggaagugac agccucauua aggguaagaa augagugugg acaucaagaa 1020ccccaccacc agagaaguug gcacacuugu ccagcuugga ggagccagcu cggggucaag 1080cacagcccac ccugccccag gcaucaugug auggacuuuu cuguaucugc ccucuuggau 1140uaaggaagac ugagaccagc ccuuucagag gcuuuccucc uuccuguguu ggcugggaag 1200cgggguggac aaugugauuu cuccgugauu uccuacagcc uugagccucu cccagagugg 1260gggagauaac caccaugcca ggaauuc 1287124612RNAHomo sapiens 124acccaccggc uuucggacca uggccaaccu cgagcguacc uucauugcca ucaagccaga 60uggcgugcag cgcggccugg ugggcgagau caucaaacgg uucgagcaga agggguuccg 120ccugguggcc augaaguucc uucgggccuc ugaagaacac cugaagcagc auuacaucga 180ccugaaagac cguccuuucu ucccggggcu ggugaaguac augaacucgg ggcccguggu 240ggccaugguc ugggaggggc ucaauguggu gaaaacgggc cgagugaugc ugggggagac 300caauccagcu gauucaaaac caggcaccau ccguggggau uucugcauuc aaguuggcag 360gaacaucauu cauggcagug auucagugga gagugcugag aaagagaucc aucugugguu 420uaagcccgaa gaacugaucg acuacaaguc uugugcccau gacugggugu acgaguagac 480augaagaaac cagaauccuu uucagcacua cugauggguu ucuggacaga gcucuucauc 540ccacugacag gauggaucau cuuuucuaaa acaauaaaga cuuuggaacu gaaaaaaaaa 600aaaaaaaaaa aa 612125529RNAHomo sapiens 125uuuugcuuuc aacaugacag augccgcugu guccuucgcc aaggacuucu 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cggugaggac 60ggcugugcag ccaaggaacc gggacagcga agcgacggca ggucgcagcu ggaucgcagg 120agccugggag cugggagcuu cagaggccgc ugaagcccag gcugggcaga ggaaggaagc 180gagccgaccc ggaggugaag cugagagugg agcguggcag uaaaaucaga cgacagaugg 240acagugugac aggaacguca gagaggauug ggccucgcug cgagagucag ccuggaguca 300agguguugac aaguugcuga gaaggacacg ugggaggacg guggcgcgcg gagggagagc 360ccugucuuca gucaccccgu ugauggagga cagauggaca gcagccggac ggccagucac 420cucucuuaaa ccuuuggaua gugguccuuu gugcucugcu ggacaccugu uggggauuuu 480agcccauucu cugaacucac uuucucuuaa aacguaaacu cggacggcag ugugcgagcc 540agcuccucug uggcagggca cuagagcugc agacaugagu gcagagggcu accaguacag 600agcacuguac gacuacaaga aggagcgaga ggaagacauu gaccuacacc ugggggacau 660acugacugug aauaaaggcu ccuuaguggc acuuggauuc agugauggcc aggaagcccg 720gccugaagau auuggcuggu uaaauggcua caaugaaacc

acuggggaga ggggagacuu 780uccaggaacu uacguugaau acauuggaag gaaaagaauu ucacccccua cucccaagcc 840ucggcccccu cgaccgcuuc cuguugcucc ggguucuuca aaaacugaag cugacacgga 900gcagcaagcg uugccccuuc cugaccuggc cgagcaguuu gccccuccug auguugcccc 960gccucuccuu auaaagcucc uggaagccau ugagaagaaa ggacuggaau guucgacucu 1020auacagaaca caaagcucca gcaacccugc agaauuacga cagcuucuug auugugaugc 1080cgcgucagug gacuuggaga ugaucgacgu acacgucuua gcagaugcuu ucaaacgcua 1140ucucgccgac uuaccaaauc cugucauucc uguagcuguu uacaaugaga ugaugucuuu 1200agcccaagaa cuacagagcc cugaagacug cauccagcug uugaagaagc ucauuagauu 1260gccuaauaua ccucaucagu guuggcuuac gcuucaguau uugcucaagc auuuuuucaa 1320gcucucucaa gccuccagca aaaaccuuuu gaaugcaaga guccucucug agauuuucag 1380ccccgugcuu uucagauuuc cagccgccag cucugauaau acugaacacc ucauaaaagc 1440gauagagauu uuaaucucaa cggaauggaa ugagagacag ccagcaccag cacugccccc 1500caaaccaccc aagcccacua cuguagccaa caacagcaug aacaacaaua uguccuugca 1560ggaugcugaa ugguacuggg gagacaucuc aagggaagaa gugaaugaaa aacuccgaga 1620cacugcugau gggaccuuuu ugguacgaga cgcaucuacu aaaaugcacg gcgauuacac 1680ucuuacaccu aggaaaggag gaaauaacaa auuaaucaaa aucuuucacc gugauggaaa 1740auauggcuuc ucugauccau uaaccuucaa cucugugguu gaguuaauaa accacuaccg 1800gaaugagucu uuagcucagu acaaccccaa gcuggaugug aaguugcucu acccaguguc 1860caaauaccag caggaucaag uugucaaaga agauaauauu gaagcuguag ggaaaaaauu 1920acaugaauau aauacucaau uucaagaaaa aagucgggaa uaugauagau uauaugagga 1980guacacccgu acuucccagg aaauccaaau gaaaagaacg gcuaucgaag cauuuaauga 2040aaccauaaaa auauuugaag aacaaugcca aacccaggag cgguacagca aagaauacau 2100agagaaguuu aaacgcgaag gcaacgagaa agaaauucaa aggauuaugc auaaccauga 2160uaagcugaag ucgcguauca gugagaucau ugacaguagg aggagguugg aagaagacuu 2220gaagaagcag gcagcugagu accgagagau cgacaaacgc augaacagua uuaagccgga 2280ccucauccag uugagaaaga caagagacca auacuugaug uggcugacgc agaaaggugu 2340gcggcagaag aagcugaacg aguggcuggg gaaugaaaau accgaagauc aauacucccu 2400gguagaagau gaugaggauu ugccccacca ugacgagaag acguggaaug ucgggagcag 2460caaccgaaac aaagcggaga accuauugcg agggaagcga gacggcacuu uccuuguccg 2520ggagagcagu aagcagggcu gcuaugccug cuccguagug guagacggcg aagucaagca 2580uugcgucauu aacaagacug ccaccggcua uggcuuugcc gagcccuaca accuguacag 2640cucccugaag gagcuggugc uacauuauca acacaccucc cucgugcagc acaaugacuc 2700ccucaauguc acacuagcau acccaguaua ugcacaacag aggcgaugaa gcgcugcccu 2760cggauccagu uccucaccuu caagccaccc aaggccucug agaagcaaag ggcuccucuc 2820cagcccgacc ugugaacuga gcugcagaaa ugaagccggc ugucugcaca ugggacuaga 2880gcuuucuugg acaaaaagaa gucggggaag acacgcagcc ucggacuguu ggaugaccag 2940acguuucuaa ccuuauccuc uuucuuucuu ucuuucuuuc uuucuuucuu ucuuucuuuc 3000uuucuuucuu ucuuucuuuc uuucuaauuu aaagccacaa cacacaacca acacacagag 3060agaaagaaau gcaaaaaucu cuccgugcag ggacaaagag gccuuuaacc auggugcuug 3120uuaacgcuuu cugaagcuuu accagcuaca aguugggacu uuggagacca gaagguagac 3180agggccgaag agccugcgcc uggggccgcu ugguccagcc ugguguagcc ugggugucgc 3240uggguguggu gaacccagac acaucacacu guggauuauu uccuuuuuaa aagagcgaau 3300gauauguauc agagagccgc gucugcucac gcaggacacu uugagagaac auugaugcag 3360ucuguucgga ggaaaaauga aacaccagaa aacguuuuug uuuaaacuua ucaagucagc 3420aaccaacaac ccaccaacag aaaaaaaaaa aaaa 3454128199RNAHomo sapiensmisc_feature(136)..(136)n is a, c, g, or u 128uuuuuuuuuu uuguuuuaau uuggcuccaa ugaucgcauu cucaaacucc uuugggaggg 60cauuagauga cccaguaucc gacgacuuag auucacacgu guuuuucucc ucugagcucu 120uuucuccagg cucacngucu uuguuuuuca agcuuucuug ggccuuugaa caauuuucuu 180ccuuugaaga uucuccugg 1991291706RNAHomo sapiens 129agccgaguag gaccgagcug cugcagacgc gccgggucac ucgagccagc accaccguuc 60ucacgcccug agcugcagac agcuaggcgg uuuuaucuag uuugaaccag gcugcuggag 120cuugcucccu cccgcccucu cucuuuuuuu uccacggggc uguuuuuuua auuuggcugc 180aauugcauga aaucccaaug guguagacca guggcgaugg aucuaggagu uuaccaacug 240agacauuuuu ccauuucuuu cuugucgucu uugcugggaa ccgaaaacgc uuccgugaga 300cuugacaaua gcucuggugc aaguguggua gcuaucgaca acaaaauaga gcaagcuaug 360gaucugguga aaagccauuu gauguaugcg gugagggagg aaguggaagu ucugaaggag 420cagaucaaag aacuaauaga gaaaaacucc 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uguccguaac 1320uacuguuuag cuucuacaca uugaaaugua gauguuucau uggcugucug aaaaggugug 1380gcuuguccuu ccuagagaga ucuacuuaaa aacugcuuug uggcaaaaac cacaccugaa 1440gaaauuuuaa gaauuuggcc caguuaguca cucuguguaa ucccggaauc uagcugcuga 1500agucuugcga aguaaacucc ccgugaccga ugucaguuaa gcuggugaua ccuggagaag 1560uggucaguug cuaaggaagu ggauuuccca guagggguuu cugcaccuca ccuguauagu 1620cguucugcgc auguccccca cacagucccc accuguauuu accuguucua cuugucaccu 1680uucaauaaag cauaucaaau guugau 17061302175RNAHomo sapiens 130auggcugcgc acgucuggcu ggcggccgcc cugcuccuuc ugguggacug gcugcugcug 60cggcccaugc ucccgggaau cuucucccug uugguucccg aggugccgcu gcuccggguc 120uggguggugg gccugagucg cugggccauc cuaggacuag ggguccgcgg gguccucggg 180gucaccgcag gagcccaugg cuggcuggcu gcuuugcagc cgcugguggc cgcacugagu 240uuggcccugc cuggacuugc cuuguuccga gagcuggccg ccuggggaac acuccgggag 300ggugacagcg cuggauuacu guacuggaac agucguccag augccuucgc uaucaguuau 360guggcagcau ugcccgcagc cgcccugugg cacaaguugg ggagccucug ggcgcccagc 420ggcaacaggg acgcuggaga caugcugugu cggaugcugg gcuuccuggg cccuaagaag 480agacgucucu accugguucu gguucucuug auucucucuu ggcuugggga aauggccauu 540cccuucuuca cgggccgcau cacugacugg auucuucagg auaagacagu uccuagcuuc 600acccgcaaca uauggcucau guccauucuc accauagcca gcacagcgcu ggaguuugca 660agugauggaa ucuacaacau caccauggga cacaugcacg gccgugugca cagagaggug 720uuucgggccg uccuucgcca ggagacaggg uuuuuccuga agaacccagc agguuccauc 780acaucucggg ugacugagga cacagccaac gugugcgagu ccauuaguga cacgcugagc 840cugcugcugu gguaccuggg gcgagcccug ugucucuugg uguucauguu uuggggguca 900ccguaccuca cucuggucac ccugaucaau cugccccugc uuuuucuuuu gccuaagaag 960cugggaaaag ugcaccaguc acuggcagug aaggugcagg agucucuagc aaaguccacg 1020cagguggccc uugaggccuu aucggcgaug ccuaccgugc ggagcuuugc caacgaggag 1080ggugaggccc agaaguucag gcagaaguug gaagaaauga agacgcuaaa caagaaggag 1140gccuuggcuu acgucgcuga agucuggacc acgagugucu cgggaaugcu gcugaaggug 1200ggaauucugu accugggcgg gcagcuggug aucagaggga cugucagcag cggcaaccuu 1260gucucauucg uucucuacca gcuucaguuc acccaggcug uucagguccu gcucucccuc 1320uaccccucca ugcagaaggc ugugggcucc ucagagaaaa uauucgaaua cuuggaccgg 1380acuccuugcu cuccacucag uggcucguug gcacccucaa acaugaaagg ccuuguggag 1440uuccaagaug ucucuuuugc cuacccaaac cagcccaaag uccaggugcu ucaggggcug 1500acguucaccc ugcauccugg aacggugaca gcguuggugg gacccaaugg aucagggaag 1560agcaccgugg cugcccugcu gcagaaccug uaccagccca ccgggggcca gcugcugcug 1620gauggccagc gccuggucca guaugaucac cauuaccugc acacucaggu ggccgcagug 1680ggacaagagc cgcugcuauu uggaagaagu uuucgagaaa auauugcgua uggccugaac 1740cggacuccaa ccauggagga aaucacagcu guggccgugg agucuggagc ccacgauuuc 1800aucucugggu ucccucaggg cuaugacaca gagguaggug agacugggaa ccagcuguca 1860ggaggucagc gacaggcagu ggccuuggcc cgagccuuga uccggaagcc acuccugcuu 1920aucuuggaug augccaccag ugcccuggau gcuggcaacc agcuacgggu ccagcggcuc 1980cuguaugaga gccccaagcg ggcuucucgg acgguucuuc uuaucaccca gcagcucagc 2040cuggcagagc aggcccacca cauccucuuu cucagagaag gcucugucgg cgagcagggc 2100acccaccugc agcucaugaa gagaggaggg ugcuaccggg ccaugguaga ggcucuugcg 2160gcuccugcag acuga 2175131970RNAHomo sapiens 131gaauuccggg gccgcucucu ccggcaggau cgccgcgaug gccgcccagg gagagccgca 60gguccaguuc aaggucgucc uggugggcga cggcggcacc ggaaagacga cauucaugaa 120gcgccacuug accggagagu uugagaagga guauguagcc acccugggcg uggaggugca 180cacauuaguc uuccauacca acagaggacc uaucaaguuc aauguguggg acacagccgg 240ucaggagaag uucggggggc ugcgcgaugg cuacuacauc caagcccagu gugccauuau 300aauguuugac guaacaucaa gaguuacuua caagaaugug ccuagcuggc auaaagaucu 360agugcgugug ugugaaaaca uccccauugu auuguguggc aacaaagugg auguuaaaga 420caugaaagug aaggcaaaac cuauucucuu ccaccgaaag aagaaucuuc aguacuauga 480cauuucugcc agaaguaacu acaacuuuga aaagccuuuc uucuggcuug ccagaaagcu 540cauuggagau ccuaacuugg aguucguugc caugccugcu cuugccccac cugagguagu 600cauggaccca gcuuuggcag cacaguacga gcaugauuua gagguugcuc agacgacugc 660ucucccagau gaggaagaug accugugaga aagugaagcu ggagcccugc gucagaaguc 720uauuuuaggc aacuguccug ugaugccagc cagcggugca gugugugugc caccuuauuu 780agcuaaagga gaucgugcaa uucauuggga ugcugaagga gaugaauggg cuucggagug 840aauguggcag uuaaaauaca ccuucauuuu uuuggacuug cguauuuagc ccccuggaac 900agaguuguuc uggauuucaa agauaagacu gcuaccguag caucacaaua gucaguggug 960accggaauuc 970132356RNAHomo sapiens 132uuuuuuuuuu uuuuuuugau uuaugaaaag uuuuauuuau caguacugug aagaauucuc 60aucauaauug cuacguuaau caaggaaaag gcacagagaa gcaugugucg uuugaguccu 120cgauacugga ccucccagcc caugcucccu augaggaguc uagcugcugu gguggucuuc 180acagcuuugg uuuucuggag acgaagcuca ugauugcguu caugcacucc ucugacagcc 240accuugcuug cagaguagug cacucuucag cguugacugc guagagcuuu ucuuucucau 300uuuuucugau uaacucuuug gaaauucuca uuggguuugg cgggagcuuc gcauau 356133626RNAHomo sapiens 133ucgggaaucg auugagagac cgcgaaccug uaaacggaug auaccgaguc gggcaggcgu 60uaugccagcc caacucggga ccucgcauca uguccgcggc uaccuuagag uguuucggga 120augauuugcg guggaugaac gaaaccccgg uacguccugu gccaaggagc auaugucagg 180acggacgcuc guuaaugccu cagugguggg gcaacguucg cucucuaucu auacgacucu 240cgacaaugga uaucucggcu cucgcaucga ugaagaacgu agcgaaaugc gauacuuggu 300gugaauugca gaauccugug aaccaucgag ucuuugaacg caaguugcgc ccgaggccuu 360ucgguugagg gcacgccugc cugggcguca cgccuuguuu ugcucugugc ccgugcucuu 420ucgggggcgg ucauggaugc ggagauuggc ccuccgugcc ucgugugcgg cgggcuuaag 480cgcggggugu cggcgucggg aagggcacga cgaguggugg acggagcacc agcaggaugu 540uguggucccc cgucaccuua aggggcucaa gagacccgga cuaggcgagc cgcgcuucgu 600aagaggaggg cgagcugucu cgcaau 626134495RNAHomo sapiensmisc_feature(485)..(485)n is a, c, g, or u 134uuuuuuuuuu uuuuuuugaa guugcugccc cuuuauuggu gacccgggca aguuuaagga 60gaacaacauu aaagcacaca aaguguaucc augucaccag cucaaccagg aggagugagg 120gucacggcag gguucuccca ugguguaaga aaucaacgca auuucaucac accccguuac 180uuuccaaguu aacgaaccga uaagaaaaga uucucccuua aacugacaag uacaauguac 240auguacauga uuuuggaaua auuuaauacu uuaaccucaa gauacaacua uauucuaaga 300ccauuauuuu aaaggaacgg auccuuacaa aaccaaaaua acccauauag cacgagguug 360guuuagccuu ucuucuucuu ucaacaaacg ugcaccacau guuucaguag caaggccgau 420gccauggaua ugagagcugu gauuugcagg gaccaaccac aucuagaacc ggggaggcca 480aucanacggu ggguu 495135257RNAHomo sapiensmisc_feature(254)..(254)n is a, c, g, or u 135cccuuggagg auaguuuuau ugacaagucg aguuagguuu uagaguaaac uuuuaucacc 60ccagucaggc cccuucccag gggaggcucg cugguagcuc agauggccuu gguggugggc 120agauuguugu aguugucuuc cuggcccucc agcaggcuuc gggagguggc uaucuccugc 180uccagccugg acuugauguc caguagcugc uuauacuccg gguucuggcg cucuaugugc 240ggcacgcagg ugcngcg 2571361186RNAHomo sapiens 136ggacugacuc cuugggcaga uugccucucc uccuucucau gccagaggcu gcugaugagg 60aaagguccag gggacugucc augcugucuu cauccucaga gucacugccu gaugcugcaa 120caagacccuu cuuguuuagc aauagugguu ggaacacucu cuuguaaguu accggagcac 180uaguauagga ggaggaucau cgacuacccu cccgccacuc cacggcugcu ggcuccuaga 240aaccccagcu ucaccucuca cugggacucg aguuccagaa ugaaaagcaa gaagggucuu 300guugcagcau caggcaguga cucugaggau gaagacagca uggacagucc ccuggaccuu 360uccucaucag cagccucugg caugagaagg aggagaggca aucugcccaa ggagucaguc 420cagauucugc gagacuggcu guaugaacac agauacaacg ccuaucccuc agagcaagag 480aaagcacugc ugucccagca gacacaccug uccacacuac aggucuguaa cugguucauc 540aacgcccgcc gcaggcuccu uccugacaug cugagaaagg auggcaaaga uccaaaucag 600uucacgauuu cccgccgugg ggccaagauu ucagaagcua gcucuauuga agcugcaaug 660gguaucaaaa acuucaugcc aacucuagaa gagagcccau uucauuccug cguaguugga 720cccaacccaa cccuagggag accagugucu cccaaaccuc ccuccccagg auccauuuug 780gcucgcccgu cagugaucug ccauaccacu gugacugcau ugaaggaugg gccuuucucu 840cucugucagc cgauuggugu gggacagagu acagauguac cgcaaauagc acccagcaac 900uuuacagaca ccucucucgu guacccagag gacacuugca aaucuggacc caguccaaac 960ccucagagug gucuuuucaa cacuccuccc ccuacuccac cagaccucaa ccaggauuuu 1020aguggauucc agcuucuagu ggauguugca cucaaacgag cggcagagau ggagcuucag 1080gccaaacuca cagcuuaacc guuuuuucaa acaaaacagu ucuccaaaau acgguccuga 1140uugccggggg ugauggcaag agaugcauua uuuuauauau uuuuuc 1186137455RNAHomo sapiens 137uuuuuuuuuu uuuuuuuggu gguuaucaag ugcacuuuau ugaauccacu guggauagau 60aaaugagugu uacaccugcg uguagggagg ggcaaggagg gacgcagcug cggaggguga 120agcacuucag gaccggaagu cggaauccuc uauuaagugu gaagguuuug agcguuaaga 180acaaugauga ugacacuaac aauggugaua acaaccauca ggaugcugag gaccaaggug 240cugauguuca ggcacuuagc aguggaggcg uaggccuggg cuccagucac aucacccacc 300aucuuccgau cccuagacuu cacggaguag gcauaggcua ugaagcccag gcagcagaag 360uucaugaaga guguauugaa cagggaccag accacauggu caggcaccga caccucucug 420ggcauguuga ucacaguagu ucugacagaa gccga 4551381797RNAHomo sapiens 138aagcuucagg auacagugca cacucguaaa uaaaaacuac aggcugcugc gaauuauauu 60ucaacugacc ggagaggcaa agccugacug uccauuaacc cuuaacuucc aaacgcaaac 120ugcuuacugc aucuuuuggc auuuuaccuu augccuuguu agguccaagg caagagaagc 180gucaucaaua accacgcaug ugcaacagcu uuuccagagg aaaggugugg guggcucuua 240aaagagccuu ugaguuagga gugugaguua aacgagcuca cuuggagcug guguacuugg 300ugacugccuu ggugcccucc gacaccgcgu gcuuggccag cuccccgggc agcagcaggc 360gcacggccgu cuggaucucc cgggacguga uggucgagcg cuuguuguaa ugcgccaggc 420gggaagccuc gcucgcgaug cgcucgaaga ugucguucac gaacgaguuc augaugccca 480uggccuugga ggagaugccg gugucggggu gcacuugcuu cagcaccuug uacacguaca 540ccgaguagcu cuccuugcgg cugcgcuugc gcuucuugcc guccuucuuc ugggccuugg 600ugacggccuu cuuggagccc uucuucgggg cgggagcgga cuuggcgggc ucaggcauac 660ugagaggaug aagugaacua aguugaaaaa ggauaacuaa aaguuaauga cuguucuggc 720ugcaauuuua aacaaacuua cggcuauggc aaccugaauc accauacguc auguacuaac 780aguccaauca aaacaaggga uuuucaaacc agggcgccau ugguaaccaa uguguaacca 840augaaaucuc uccguuuucg cguccagccu ugacuauaua uacuaugcgu auacguuuuu 900gcuucuuacu gcggugguua ucuacagcug aguuaugucu ggacguggca agcaaggacg 960uggcaagcaa ggaggcaagg cccgcgccaa ggccaagacg cgcuccuccc gggccggccu 1020gcaguucccc gugggccgcg ugcaccggcu gcuccgcaag ggcaacuacu cggagcgcgu 1080gggcgccggc gccccggugu accuggcggc cgugcuggag uaccugacgg ccgagauccu 1140ggagcuggcg ggcaacgcgg cccgcgacaa caagaagacg cgcaucaucc cgcgccaccu 1200gcagcuggcc auccgcaacg acgaggagcu caacaagcug cugggccgcg ugaccaucgc 1260gcagggcggc guccugccca acauccaggc cgugcugcug cccaagaaga ccgagagcca 1320ccacaaggcc aaggggaagu gaaaccaaac auuacgaauc accaaggcuc uuuucagagc 1380cacucacuuu cucaaagaga ccuaacacua cugggauagu gcauuguggg aaauacgugu 1440auuaaccuuc cuccuauuuu cccugcuugu gguuaguuca accccuaagc cuuaggcuaa 1500gaguauauug guuuuuggaa ggcaggcacc caaccucgga ccuaguacau aaaacagaca 1560caucuugaac uccaggccag ccuacucugc aggacgaguu ccaggacaga ccggacugca 1620caaagaauug ucuugaaaug uuccuuuauc agcacauaug cugauaaaca acuaaucacu 1680guacaaucaa uccucacuug aauccuguuu auguggcaug auugacaagu ccugccauuu 1740ggcaaaguca aaaucagcaa aggauguuaa agcauuuggu gguaucacag cuaaaac 1797139376RNAHomo sapiens 139uuuuuuuuuu uuuuuaugca aauaguuuuc aagauuuuau ugcaaaccaa aauugguuua 60ucgcacacaa aaaaaguugu gugguaagga ggaggaauug uacaggauua uaacccaugu 120uaauuacagu acauuaaaau gaugguuuac aaauaagccu guaaguuuaa auaucuagug 180uuauaaccca auguacagac uuccuuuaca cgauacauac aauaaucagg aaugcaaaag 240aauaugaaca aagggaaaaa aaacauaaau aaugcccguu uuauagguga cauuuuaaac 300aauugaaaac accaaccggc uuugacugac aacuggggca uugguccaua aaaacccuuu 360cuaaaaauag aaauau 3761401068RNAHomo sapiens 140gaggcugcuc aagagcugcg guugggucac cgcuucaugu uucucugccg auucugggga 60aagauggcaa cgaaugaugc uguucugaag aggcuggagc agaagggugc agaggcggau 120cagaucaucg aauaucucaa gcagcagguu gcucuucuua aggagaaagc aauuuugcag 180gcaacaauga gagaagaaaa gaaacuucga guugaaaaug cuaaacugaa aaaagaaaua 240gaagagcuaa agcaagagcu gauucuggca gaaauucaua acggagugga gcaagugcgu 300guucgauuga guacuccacu gcagacgaac uguacugcuu cugaaagugu ggugcagucu 360ccaucaguag caaccaccgc cucuccugcu acaaaagagc agaucaaagc gggagaagaa 420aagaagguga aagagaagac ugaaaagaaa ggagagaaaa aggagaagca gcagucggca 480gcagcaagua cugacuccaa gccuaucgac gcaucgcguc uggaucuucg aauugguugu 540auuguuacug ccaagaagca cccugaugca gauucacugu auguggagga aguagaugug 600ggagaagcag ccccgcgcac ggucgucagc gggcugguga aucauguucc ucuagaacag 660augcaaaauc guaugguggu uuuacucugu aaucugaagc cugcaaagau gcggggaguu 720cugucucaag ccauggugau gugugccagu ucaccagaga aaguggagau ucuggccccu 780cccaacgggu ccguuccugg ggacagaauu acuuuugaug cuuuuccugg agagccugac 840aaggagcuaa acccuaagaa gaagaucugg gagcagaucc agccugaccu gcacaccaau 900gcugagugug uggccacaua caaaggagcu cccuuugagg

ugaaggggaa gggaguuugc 960agagcccaaa ccauggccaa uaguggaauu aaauaagugc ucuguaacug aaagacauug 1020gcgaaaacuu aauaacaaua aagagaagug uguuuaucac uuacauau 1068141165RNAHomo sapiens 141ggccuuguuu uugguuugca auaaagagua uuucuuuaaa aggcacauuu uguuaaauag 60gcaguucccc uccugccucu uccuuuguag caguguacug cauccuagaa acauuuagca 120aagcagcccu uagccucccc gacccccuuu cccucccucc cagca 165142324RNAHomo sapiens 142uuuuuuuuuu uuuuuuuaaa caaugacgcc guuuauuuaa aauguuuacu cccagaaaua 60uagauauaaa aaaaaaaaua agacaauuaa cagcacuaaa ccaggcaccu ucaaccgaau 120cccaccaucc ucguuaacuc ccuuccuguu acccuuugua gaugaccaga agauuucagg 180agccccugga cagccagagu gguuccugcc cagggcuucc cgccuuccuc cuguccuaga 240gcuucccgug ggaaagcuug ggugagaauu uuagccuaaa gggagggggc uguggccggg 300cacuuugcgc ucauccacug cagg 3241432473RNAHomo sapiens 143acaggguaca guugugcguc agggcgugga ggucuggcgg gagacgcaua guuacagcgc 60guccguucuc cgucucgcag ccggcacagc uagagcuucg agcgcagcgc ggccauggau 120cccagcagca agaaggugac gggccgccuc auguuggcug ugggaggagc agugcucgga 180ucacugcagu ucggcuauaa cacugguguc aucaacgccc cccagaaggu uauugaggag 240uucuacaauc aaacauggaa ccaccgcuac ggagagccca ucccauccac cacacucacc 300acgcuuuggu cucucuccgu ggccaucuuc ucugucgggg gcaugauugg uuccuucucu 360gucggccucu uuguuaaucg cuuuggcagg cggaacucca ugcugaugau gaaccuguug 420gccuuugugg cugcugugcu uaugggcuuc uccaaacugg gcaaguccuu ugagaugcug 480auccugggcc gcuucaucau cgguguguac ugcggccuga cuacuggcuu ugugcccaug 540uaugugggag aggugucacc uacagcucua cguggagccc uaggcacacu gcaccagcug 600ggaaucgucg uuggcauccu uauugcccag guguuuggcu uagacuccau caugggcaau 660gcagacuugu ggccucugcu gcucaguguc aucuucaucc cagcccugcu acaguguauc 720cuguugcccu ucugccccga gagcccccgc uuccugcuca ucaaucguaa cgaggagaac 780cgggccaaga gugugcugaa gaagcuucga gggacagccg augugacccg agaccugcag 840gagaugaaag aagagggucg gcagaugaug cgggagaaga aggucaccau cuuggagcug 900uuccgcucac ccgccuaccg ccagcccauc cucaucgcug uggugcugca gcugucccag 960cagcugucgg guaucaaugc uguguucuac uacucaacga gcaucuucga gaaggcaggu 1020gugcagcagc cuguguacgc caccaucggc uccgguaucg ucaacacggc cuucacugug 1080gugucgcugu uuguuguaga gcgagcugga cgacggaccc ugcaccucau uggccuggcu 1140ggcauggcag gcugugcugu gcucaugacc aucgcccugg ccuugcugga acggcugccu 1200uggauguccu aucugagcau cguggccauc uuuggcuuug uggccuucuu ugaaguaggc 1260ccugguccua uuccaugguu cauuguggcc gagcuguuca gccaggggcc ccguccugcu 1320gcuauugcug uggcuggcuu cuccaacugg accucaaacu ucauuguggg caugugcuuc 1380caguaugugg agcaacugug cggccccuac gucuucauca ucuucacggu gcuccucgug 1440cucuucuuca ucuucaccua cuucaaaguc ccugagacca aaggccgaac cuucgaugag 1500aucgcuuccg gcuuccggca ggggggugcc agccaaagug acaagacacc cgaggagcuc 1560uuccacccuc ugggggcgga cucccaagug ugaggagccc cacacccagc ccggccugcu 1620cccugcagcc caaggaucuc ucuggagcac aggcagcuag augagaccuc uuccgaaccg 1680acagaucucg ggcaagccgg gccugggcgc cuuuccucag ccagcaguga aguccaggag 1740gauauucagg acuuugaugg cuccagaauu uuuaaugaaa gcaagacugc ugcucagauc 1800uauucagaua agcagcaggu uuuauaauuu uuuuauuacu gauuuuguua uuuuuuuuuu 1860uuaucagcca cucuccuauc uccacacugu agucuucacc uugauuggcc cagugccuga 1920ggguggggac cacgcccugu ccagacacuu gccuucuuug ccaagcuaau cuguagggcu 1980ggaccuaugg ccaaggacac acuaauaccg aacucugagc uaggaggcuu uacgcuggag 2040gcgguagcug ccacccacuu ccgcaggccu ggaccucggc accauagggg uccggacucc 2100auuuuaggau ucgcccauuc cugucucuuc cuacccaacc acucaauuaa ucuuuccuug 2160ccugagacca guuggaagca cuggagugca gggaggagag ggaagggcca ggcugggcug 2220ccagguucua gucuccugug cacugagggc cacacaaaca ccaugagaag gaccucggag 2280gcugagaacu uaacugcuga agacacggac acuccugccc ugcuguguau agauggaaga 2340uauuuauaua uuuuuugguu gucaauauua aauacagaca cuaaguuaua guauaucugg 2400acaaacccac uuguaaauac accaacaaac uccuguaacu uuaccuaagc agauauaaau 2460ggcugguuuu uag 24731442125RNAHomo sapiens 144gcuuucuaaa cuagcaagca ucgugugggu ccuucaggag ugggagugca gacagaccug 60acagcguccg cuaagcgaca cugacuguac uuccacuccu gaaggaccca cacgaugcuu 120ucuaaacuag caagucugca gaccauugcu gcucugcgcc gaggagucca caccucaguc 180gccucugcca cgucuguugc cacaaagaag acagagcaag gcccaccauc cuccgaguac 240auuuuugaac gggaaucuaa auauggugca cacaauuacc auccuuugcc uguagcccug 300gagagaggaa aaggcauuua uaugugggau guggaaggca ggcaguacuu cgauuuccug 360agugcuuaug gugcugucag ccaaggacac ugccacccaa agaucauaga ugccaugaag 420agucaggugg acaagcugac auuaacaucu cgggcuuucu auaacaaugu ccuuggugaa 480uacgaggagu acaucaccaa gcuuuucaac uacaacaaag uucucccuau gaauacagga 540guggaggcug gagagacugc auguaagcuc gcucgucguu ggggcuacac cgugaaaggc 600auccagaaau acaaagcaaa gauuguuuuu gcugauggga acuuuugggg ucgaacacua 660ucugcaaucu ccaguuccac agauccgacc aguuaugaug gcuuuggacc cuucaugcca 720ggcuuugaaa ccaucccaua uaacgaucug cccgcacugg agcgugcucu ucaggaucca 780aauguugcug ccuucauggu ggagcccauc cagggugaag caggcguuau cguuccggau 840ccaggauacc ugacaggagu ucgggaacuc ugcaccaggc accagguccu guuuauugcu 900gaugaaauac agacaggauu ggccagaacu gguagauggc uggcugugga ucaugagaau 960gucagaccug auaugguucu ucuugggaag gcccuuucug gcgguuuaua cccugugucu 1020gcagugcugu gugacgauga gauaaugcug accauuaaac caggcgagca cggcuccaca 1080uacggcggaa acccacuagg cugccgaauu gccauugcgg cucuugaggu uuuagaagag 1140gagaaucuug cugagaaugc agacaagaug ggcgcuaucc ugaggaagga gcucaugaag 1200cugcccucug acguugugac cucagugaga gggaaagggu ugcuaaaugc cauugucauc 1260agagaaacca aagacuguga ugcuuggaag gugugccugc gacuucgaga uaacgggcuu 1320cuggccaagc caacccacgg ugauaucauc aggcuugccc cuccccuugu gaucaaggag 1380gaugagaucc gggaguccgu ggagaucauc aacaagacua ucuuguccuu cugagaguag 1440gaacucuggg gagccaucuu cagacagggc ucuugugaaa cucugcuugc aguggccaga 1500gccugucucc ugaaaggcau auauuucagu ugaugcauaa uagagugaca ccuaggaacc 1560ugcagguggc ugcgugacag aaaagugaga gcgagaggcg aggcgucucu uuguugaggu 1620uugacugugu gggaacuuuc uaaggagaaa cggacccauc ugcguacagc cugcagaugg 1680aggccugcag ucauuuacgu gcgucuuuac aguuuccuug cugaugugaa ugguuuguau 1740uuagaaguua uuucugagau acuacagaac aguuaaauca uuauaaucaa ugaauguuaa 1800guugauugaa gguuaagcau auguaaaaua cuaguuuaaa guaaacuuuu cauuggccaa 1860caccagaaug uauuauauag auucugagaa uucauuacua aauuacacuu ugcuugauug 1920caauuuguaa aacauuuauu uucaguauuu cuuugaauaa agcuuaaugu uucuuuuuac 1980gccaacagag uauuuuguau uuccauuuug guaauaauca guguauuauu ucauccugau 2040gacuggcauu ucaucaccua uugagaucac uggguguguu ucaggccuuu uauucuaaau 2100aaagcuauga ccaguuucug ucugu 2125145199RNAHomo sapiens 145uuuuuuuuuu uucuuuuccg acgcccacaa gaggaauaag agauuuaaug auggaaagua 60uggggaaauc acaguuuuca gacaugagua aucaaaaacu ugacauuuuu cuugauaucc 120aaaucuagau gucuguauca aaccagaggu gauggccuug gggauggcag ugaagacugu 180uaggaccauu agaucagau 199146412RNAHomo sapiens 146uuuuuuuuuu uuuuuuuaca guuuuaaaac aauacacagc uuucucgggc ugaagcaauu 60gcaagaacgu auugguauug guauauuaca gcuacauaca agguuuauga auagcaaugg 120agaaaaauaa guuauuuaaa uauugacuuc auaaagagaa agugcaaugu uguuaguugu 180cauaucacuu gcuugacagu uugugggguu ucuucccuau caauuuuaac aaucaagaua 240acauggacuc aagacagaau uuuucgggaa ccucacucag uccucacaca gcagugacuu 300gggaaucuac guguguucca ccgcaguugu gaaacacacu acuccguguc caggacucau 360uucucagaga agaaucaauu cgaguuccau ccacaccugg ggucgggaca ca 4121472373RNAHomo sapiens 147ccgggcucga auucucuaga cucgaguuua gagaauucga gcucucccag uuuuaaagca 60aaauuuugga cugugaagca aggcacuggg caaacacaac auggccuccc cggcugacag 120cuguauccag uuuacccggc acgcuaguga uguucuucuc aaccuuaauc gccuccggag 180ucgggacauc uugacggacg uugucaucgu ggugagccgu gagcaguuua gagcccauaa 240gacagugcuc auggccugca gcggccuguu cuacaguauc uucacugacc aguugaaaug 300caaccuuagu guaaucaauc uagauccuga aaucagcccu gagggguuuu gcauccuccu 360ggacuucaug uacacaucua ggcucaaccu gagggaaggc aauaucaugg cggugaugac 420cacagccaug uaccugcaga uggagcaugu ugucgacaca ugcaggaagu ucaucaaggc 480cagugaagca gaaauggccc cugcacuuaa accuccccgu gaagaguucc ugaacagccg 540gaugcugaug ccccaugaca ucauggccua ccgaggucgu gaggucgugg agaacaauau 600gccacugaga aauacucccg ggugugagag cagagcuuuu gcuccuccuc uguacagugg 660ccugucaaca ccaccagccu cuuaucccau guacagccau cucccgcuca gcaccuuccu 720cuucucugau gaggagcucc gagaugcccc ccgaaugccu guggccaacc cuuuucccaa 780ggagcgugcc cuccccugcg acagugccag gcaagucccu aaugaguaua gcaggccagc 840cauggaggug ucccccaguu ugugucacag caacaucuac ucgcccaagg aggcaguccc 900agaggaggcu cggagugaca uacacuacag ugugccugag ggccccaagc cugcuguccc 960uucugcucgg aaugcuccau acuuccccug ugacaaagcc agcaaagaag aagagagacc 1020uucuucggag gaugagauug cccugcauuu cgagcccccc aaugcacccu ugaaccggaa 1080gggucugguu aguccccaga guccccagaa auccgacugc cagcccaacu cacccacaga 1140guccugcagc agcaagaacg ccugcauccu ucaggccucu ggcucuccgc cagccaagag 1200ccccacugac ccgaaagccu gcaacuggaa gaaguauaag uucaucguuc ucaacagccu 1260caaucagaau gccaaacccg agggcucuga gcaggcagag cugggucgcc ucuccccucg 1320agccuacccu gcaccgcccg cuugccagcc gccuauggag cccgcgaacc uugaucucca 1380guccccgacc aagcucagug ccagugggga ggacucuacc aucccccaag ccagccggcu 1440caauaaucuc gugaacaggu cccugggagg cuccccccga agcagcagug agagucacuc 1500accacucuac augcaccccc caaagugcac auccugcggc ucucaguccc cacagcauac 1560agagaugugc cuccauacug cugggcccac guucccggag gagauggggg aaacccaguc 1620agaguauucg gauucuagcu gugagaaugg gaccuucuuc ugcaacgaau gugacugccg 1680uuucucugag gaggccucgc ucaagaggca cacgcugcag acgcacagug acaaaccaua 1740caaaugugau cgcugccagg ccuccuuccg cuacaagggc aaccucgcca gccacaagac 1800uguccacacg ggugagaaac ccuaucgcug uaacauuugu ggagcgcagu ucaaucggcc 1860agccaaccug aagacccaca cucgaauuca cucuggagaa aagcccuaca aaugugaaac 1920cuguggggcc agguuuguuc agguggccca ccuccgugcc cacgugcuca uccacacugg 1980agagaagccg uaccccugug aaaucugugg cacucgcuuc cggcaccuuc agacucugaa 2040gagccaucug cgcauccaca caggagagaa accuuaccau ugugagaagu guaaccugca 2100cuuucgucac aaaagccaac ugcgacuuca uuugcgccag aagcacggcg ccaucaccaa 2160caccaaggug caauaccgcg ugucggccgc ugaccugccu ccggagcucc ccaaagccug 2220cugaaugaag cauggagugu uccucgcccu uuccucucca gccccuucuc agaaucuacc 2280caaaggaugc uguaacacuu uauacaaagg ucaucccaug auguagugcc ucucucaucc 2340acuagugcaa aucauaguug gggugggggu ggg 2373148989RNAHomo sapiens 148ucgcgguccg acggaggagu gggcgcuggg aucucgcuga gcguccgccu ggccucgucu 60cuuccucgcu cgucggagcu ucagcacggu ccgagauggc uggcgguaag gcuggaaagg 120acuccggaaa ggccaagaca aaggcgguuu cccgcucgca gcgagccggc uugcaguucc 180cugugggccg uauucaucga caccugaaau cuaggacaac cagccacgga cgugugggcg 240cgaccgccgc uguguacagc gcagccaucc uggaguaccu caccgcagag guacuugagu 300uggcaggaaa ugcgucaaaa gacuuaaagg uaaagcguau caccccucgu cacuugcagc 360uugcuauacg uggagaugaa gaauuggauu cucugaucaa agcuaccauu gcugguggug 420gugucauccc acacauccac aaaucgcuga ucgggaagaa aggacaacag aagacuguuu 480aaggaugccu ggauuccuua uuaucucagg acucuaaaua uuccuaacag cuguccagug 540uuggugauuc caguggacug uaucucugug aaaaacacaa uuuugccuuu uuguaauucu 600auuugagcaa guuggaggcu uaauuagccu uccaaccaac caaauuucug cauucgaguc 660uuaaccauau uuaaguguua cuguggcuuc aaagaagcua uugauucuga aguagugggu 720uuugauugag uugacuguuu uuaaaaaacu guuuggauuu uaauugugau gcagaaguua 780uaguaacaag cauuugguuu uguacagaca uuguuuccac ucugguggau aagcucaaua 840aaggucauau cccaaacuag cuuuaaacuu gcuuaauaau cgggucuuac cuuagaucuc 900acucagcaac aaguacauuc ucugcuuacu aauuaaacag ugcaucugua gucauaaaaa 960aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 9891496342RNAHomo sapiensmisc_feature(439)..(538)n is a, c, g, or umisc_feature(1133)..(1232)n is a, c, g, or umisc_feature(1698)..(1797)n is a, c, g, or umisc_feature(2105)..(2204)n is a, c, g, or umisc_feature(2861)..(2960)n is a, c, g, or umisc_feature(3546)..(3645)n is a, c, g, or umisc_feature(4057)..(4156)n is a, c, g, or umisc_feature(4736)..(4835)n is a, c, g, or umisc_feature(5487)..(5586)n is a, c, g, or u 149caccaccgug cacgcagcuc cgggcccgug ggguguuggu ucuugcccuc guaacccccu 60cuguccagcc accaugauaa gcgccagcag agccgcggcc gcgcgucucg ugggcaccgc 120ugcgucccgg agccccgcag ccgcccgucc ccaggugaga agcugccaug ccuuccggug 180ggggcuccag gcccggacuc gagugaggca ggccuugccu ucgggucaga cucuaggaaa 240aauccggagc gaagggaugu aacggaccuu cugugggcau uguuggccuu cuugcagggc 300uuuagcuucg aacugugcug agucacaauc cuuggcguuc cuaagucuuu accccgcuaa 360uugagacguc uguccccccu cuaaccugug cgcuuugaau gugccuggac uuaggcagug 420gacguaguuu acuggaaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnuu 540uuacauacua aggacuaaag cuugcaugug uuccucagaa uaugaaaagc ccaaguucuu 600guguaguuga uggcugaugc aacuuuuuuc cccccaggau ggcuggaaug gccuuagcca 660ugaggcuuuu agauuuguuu caagaagaga uuaugcguaa guacaaccuc aguuucucug 720agaaaaaaaa aaaacacuua uugaaccuca aagcuuggau ggguugggug cguuauacau 780uuguacuugu aguuuauuca auaugccacu gguaacacca acauaaaaca caguucuucg 840uauuggagac cacuguucag augaccaugg aauuucauuu cuuacagauc agaagcaauc 900aagggugcag ugguugguau ugauuugggu acuacuaacu ccuguguggc uguuauggag 960ggcaaacaag caaaggugag caugauugga aaccugaggu cacuuagaua cccagucugg 1020cauuaaguac auaggaaugc ugagucggag cccagguuag uggugggcac uuuaauccua 1080guaaaggcag agggaucucu gaguucagga ccagccuaga guacaaagug agnnnnnnnn 1140nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnacuuuaau cagugucuuu gggaauuuua 1260gguccuggag aaugcugaag gugccagaac uaccccuucu gugguugccu uuacagcaga 1320uggagaacga cuuguuggua ugccagcaaa acggcaagcu gucaccaauc caaacaauac 1380cuucuaugcu acuaagcguc uuauuggacg acgauaugau gacccugaag uacagaaaga 1440cacgugagua auaggaaaau caguccagaa gacuggugcu uugaucaaag uucuguggau 1500accuugaguu cuguggauca ccuuggauca cuuuuucauu auuucugcuu gggaagaaau 1560cacaccacca ucagaggcau auagguuuuu uuuuuguuau uucuuuguug uuguuguuuu 1620ccuauuuauu uguuuguuug uuuggggggg gguuucuuug uguauuuucc uggaacucau 1680ucuguagacc aggcuggnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnuca 1800ugugauauau gaugaacuua gagugguuaa guuucacagg gauaguuuac uuacauaauc 1860uuucugucuu uaaguaagaa uguuccuuuu aaaauugucc gugccuccaa uggugaugcu 1920uggguugagg cucauggaaa acucuauucu ccaagucaga uuggagcauu uguguugaug 1980aagaugaaag agacugcagg uaaguggauu uauuucacau uuaggaaaau uggaaugugc 2040uguuuauuuc ucugcauuaa uacugauuaa cuucauauuc uguagauaau ggagucugaa 2100gcuunnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngaauuc augcuccucc 2220ugcugccucc ugggugcuaa guugcaaggu gauagcucag guacucacuc uagugucuuu 2280cuuggggugc ucuuuuccaa ggccucucua cauauuaagc cacaaaggag ucuguugccc 2340cucaagagga ugagaugugg aauauuaggc uacaguuuug uugccuuuuu uuuauuuucc 2400uaacauggua ccacaauuga auuuuauucu uuguuuccca gaaaauuacu ugggccacac 2460agcaaaaaau gcugugauca cagucccugc uuauuucaau gauucacagc gacagguaaa 2520auuagaucuc uuguuugcug ggaguggagg ugggguaccu gaguuaaagg auggaaagau 2580agauuuauuu cuacuuucuc uaggccacua aggaugcugg ccagauaucu gggcuaaaug 2640ugcuucgagu gaucaaugag ccuacagcug cugcucuagc uuacggucug gacaaaucug 2700aagauaaagu guaaguuggu cagaugacgu agcauuaccu gcauuuacag ggguugugug 2760ugugugugug uguguguaau uuuacuacaa uuuguguggg uccguguguu gugguacauu 2820uguacauuug uacauggcau ggauauggau gucaaagauu nnnnnnnnnn nnnnnnnnnn 2880nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940nnnnnnnnnn nnnnnnnnnn aaaccaguag uugguguguu acuaauuuua cuuguuucug 3000uaugacaugc uuauaugaua cguuaacagg caugccacuu agguugauaa cuacauucag 3060uuauuaagua uuucaggaaa uaucauaguu aauaauuaaa cuuuuggucu uuuaauucgu 3120uccuuuguuu uguuccuugg aacuuaacuu acuuauuuau uuuuuagcau ugcuguguau 3180gauuuaggug guggaaccuu ugacauuucu auccuggaaa uucagaaagg aguguuugag 3240gugaaaucua ccaaugggga cacuuucuua ggaggggaag acuuugacca agcuuuguug 3300cggcacauug ucaaggaguu caagagagag guuaguuacc acugcuuagu caccacuggu 3360uaagguguag gcguuggguu guugagaauu uuuguuuguu ugcauugcuu uuagcuuugu 3420uaauagcuuu uuuauacuaa gguaacuaac uauacuucag auucaugggu aaacuaaacc 3480aguuuaguua uauaaucuua gauugggaac aaaagaccaa gugacagugu uauaguaggg 3540agaagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnacuac ucucucgcag 3660ucuauauaug ucuccuaauc cuauuuauag acagggguug auuugaccaa agacaacaug 3720gcgcuucaga ggguucggga agcugcugag aaggcuaaau gugaacuuuc cucaucugug 3780caggugaggg auggaaaaau cccaguacug agcauauuug aauaguguau ucuaauuuac 3840cuaaugucag uguagcucuu uacaguuuuc uguuggcuga aaacuugggg caugagcaaa 3900ggaacaacuu gaugaucagu ucuuuucauu ugaaugaaug aaguagauuu auggaugugu 3960guaucuuuug ccugcaugug ugucuguacu acauuugugc uugguuucug uggcggccag 4020aagaggguau cagaacugac augucagugu uggggannnn nnnnnnnnnn nnnnnnnnnn 4080nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140nnnnnnnnnn nnnnnncaca cugagucuaa auucugauca ugucuuucag ucguguuaug 4200uuacuuugag ugaguaucaa agaucacguc ucccaucuga cguguggucc ugugcagacu 4260gacaucaacu ugccauaccu uaccauggau gcuucuggac caaagcauuu gaauaugaag 4320cugacucgag cucaguuuga aggcauuguc acagaucuaa ucaagagaac uauugcuccg 4380ugucagaaag cuaugcagga ugcagaaguc agcaagagug acauaggaga agugauucug 4440guugguggca ugacaaggau gcccaaggua uggacucaug guauuucucc uagaggaaaa 4500aaauaacaau gcauucuuga ggcaaauggc uuguguugug uguggaaaca aaugugaucc 4560auucuucuag uguucuuuaa agagugguga gaccagacuc accaaaaagu gcuuuuaguc 4620gccugugaug gcucauguag gaggauggcc uugaguucug gguaagaugc agcuacagaa 4680uucuaccuug cacacacacu uaaacccagu cugguaaaga gaaguuguua agcuunnnnn 4740nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncagau guaaaauuga uaauacuucu 4860uccuaagauu gggcgauugu guagaauaug agaacuguau uuuauaaccc cuugucaugu 4920gccuucuauu ucaaaugaua uccucuggga agcuagauaa uuaaauucuu cucucauuua 4980aguggacagu ggaugagaug cucugaaguu gucaaauaca aacaagucug cagucuugga 5040uaugaaucuc ucugacuugc

ugucuggcag gcguauucug uuuggcucca ucagucgccc 5100uggguguugg cuaacagguu cuuucucccu gaugcuuagg uucagcagac uguacaagau 5160cuuuuuggca gagccccgag uaaagcuguu aauccugaug aggcuguagc caucggagcu 5220gccauccagg gagguguguu ggcuggugac guuacagacg ugcugcuccu ggaugucacu 5280ccccucucuc uggguauuga gacucuggga ggcgucuuua ccaaacuuau uaauaggaac 5340accacuauuc caaccaaaaa gagccaggua agagccauuc uuuuuuccug ccuauuaaca 5400gucccaaguu guacaagugc uguuuacaau cacuuuauga acucuuuaaa acuuuguuuc 5460uaagacuaua cuaacuggac ugggugnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5520nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5580nnnnnnccua gguguuuucu acugcugcug auggacaaac ucaaguagag auuaaagugu 5640gucaggggga acgagagaug gcuggagaca acaaacuucu aggacaguuc acuuugguaa 5700guguuuuuga gucugaguau caugcuuuug gggucuauag cuugcaaagc uccaaacugc 5760ugacauuaca ggcauauugu guuauuuuuu aaaaagaacg uuauguacau gaguuaugaa 5820acccaugauu uuaguuuuuu accuaaagug cuuuguguuu ucagaauuug aaauuuucaa 5880agccugggaa auguucagac ucagaagcaa ugcuaacuca gaaguuaguu uuauccugau 5940uacucauuuu aaaaaacuua auagcuacug guucugguca gcauugcuac aguagagaag 6000uuuauuugcu guaaauucug ggcacauaua accaucaugg uuauuaacuu cuugaagccc 6060agugauuuca gaaagcacua aaacuaccac caucacuuaa aaucucaagg uuuugaacau 6120ucagugaaga uacuuguuuu aggaaacaag ugguuaguug gccugauuug gaaaugagaa 6180uacaugggcc uuucaaagga gcucacucug gauauuuauu uuagauugga auucccccag 6240ccccucgugg agugccccag auugaaguua cauuugacau ugaugccaau gggauugugc 6300acguuucugc caaagauaaa ggcacugguc gugagcaaca ga 63421504145RNAHomo sapiensmisc_feature(4045)..(4045)n is a, c, g, or u 150auaaauucuu auuuugacac ucaccaaaau agucaccugg aaaacccgcu uuuugugaca 60aaguacagaa ggcuugguca cauuuaaauc acugagaacu agagagaaau acuaucgcaa 120acuguaauag acauuacauc cauaaaaguu uccccagucc uuauuguaau auugcacagu 180gcaauugcua cauggcaaac uaguguagca uagaagucaa agcaaaaaca aaccaaagaa 240aggagccaca agaguaaaac uguucaacag uuaauaguuc aaacuaagcc auugaaucua 300ucauugggau cguuaaaaug aaucuuccua caccuugcag uguaugauuu aacuuuuaca 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cgaccccuuc cccguuguua gcccuucgua 2100cacuuccucg uuuguccuca ccugcccgga ggucuccgcg uucgccggcg cccaacgcac 2160cagcggcagc gagcagccgu ccgacccgcu gaacucgccc ucccuucuug cucuguaaac 2220ucuuuagaca aacaaaacaa acaaacccgc aaggaacaag gaggaggaag augaggagga 2280gaggggagga agcaguccgg gggugugugu guggacccuu ugacucuucu gucugaccac 2340cugccgccuc ugccaucgga caugacggaa ggaccuccuu uguguuuugu gcuccgucuc 2400ugguuuucug ugccccggcg agaccggaga gcuggugacu uuggggacag gggguggggc 2460ggggauggac accccuccug cauaucuuug uccuguuacu ucaacccaac uucuggggau 2520agauggcugg cugggugggu aggguggggu gcaacgccca ccuuuggcgu cuugcgugag 2580gcuggagggg aaagggugcu gagugugggg ugcagggugg guugaggucg agcuggcaug 2640caccuccaga gagacccaac gaggaaauga cagcaccguc cuguccuucu uuucccccac 2700ccacccaucc acccucaagg gugcagggug accaagauag cucuguuuug cucccucggg 2760ccuuagcuga uuaacuuaac auuuccaaga gguuacaacc uccuccugga cgaauugagc 2820ccccgacuga gggaagucga ugcccccuuu gggagucugc uaaccccacu ucccgcugau 2880uccaaaaugu gaaccccuau cugacugcuc agucuuuccc 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auauauuaua 3780uaugagugug cgugugugug cgugugcgug cgugcgugcg ugcgugcgag cuuccuuguu 3840uucaagugug cuguggaguu caaaaucgcu ucuggggauu ugagucagac uuucuggcug 3900ucccuuuuug ucaccuuuuu guuguugucu cggcuccucu ggcuguugga gacagucccg 3960gccucucccu uuauccuuuc ucaagucugu cucgcucaga ccacuuccaa caugucucca 4020cucucaauga cucugaucuc cggunugucu guuaauucug gauuugucgg ggacaugcaa 4080uuuuacuucu guaaguaagu gugacugggu gguagauuuu uuacaaucua uaucguugag 4140aauuc 41451511756RNAHomo sapiens 151caccugauuc ccggaggccc gagcccuuag ucugggcggg guggcgcggg ccggaaggac 60gccaucccgg ccugggccau ggaggcuccc gcaccguccc ucacggagga ggauuugacu 120gaagugaaga aggacgcuuu agagaauuua cguguuuacc ugugugagaa aaucauagcu 180gagagacauu uugaucaucu acgugcaaaa aaaauacuaa guagagaaga cacugaagaa 240auuucuugcc gaacuucaag uagaaaacgg gcugggaagu uguuagacua cuuacaggag 300aaccccaggg gccuggacac ccugguggaa uccauccgca gggagaaaac acagagcuuc 360cugauucaga agauaacgga ugaggugcua aagcuucgga auauaaaacu ggagcaccuc 420aaaggccuga agugcagcag cugugagccc uuugcagccg gagccaccaa caaccucucu 480aggugcaauu ccgaugagag caaucucucu gagaaacaga gagcauccac ugucauguac 540cacccggagg gagaguccag cacggcuccc uucuucucua uggcgucguc ccugaacuug 600ccaguccugg aaguuggcag gacugaaaac agcagcuucu cuucagccac ucuuccucga 660ccuggggacc cuggggcucc cccuuugccc ccagaccuuc gguuggaaga ggggggaagu 720uguggaaacu caagugagau guuucucccc uuacggucac gggcucuuuc acgccaauga 780uacaucaccg ccuaguuguu uuacuaguga ugcaaaaugc ugugaaggag gccaucuuuc 840uauacaaacc acggugacag gucacucaca uucgaugcgu gccuuuaaaa ucaguguaca 900cauucucugu aaauaggauu uguuagggua aagaagcgcu cuggggcggc gugguguaau 960cauggugguc gugacuuuuc cauaaugucc uuucuuuuuu auuauuuuua gguguuugcg 1020uauuuugaac uuuucauaag auuaauuuua ucggaauauu ucucaauuug agaaaacaac 1080uuguggauug ggaauaaugu uuuuagcaca uuuaugcuac aaauuuucag ucugauuguu 1140uuucccacug aucuggcagu auauuuuagc aguaagcugu ugugugucag gaaagcugga 1200cacgggaaag cugccgacac acucagcagu gucccacucc uuaguucuga gaagccgucg 1260gguucugagg agacaccugg uggcacugag ccuggugacc ucagugggcc aaaauuuguu 1320uuauacucac ccugccagcg ugagugucuu acuuucacag gccuuguguc cucagucuua 1380ucuuaaagga uguuaucuug gcagggcauc acuuguaauu aauggaugau acuuguaauu 1440gacuaaaguc cucgcucuga gccguuuguu cuggcuccga gagcgcugac augugaagca 1500uggugagcag cgagggaacu gacaggaugu ggccguggcc aguguggcuu uaguguuugc 1560aucaggcagc caccagcucc auccguguuc uuacugcuuu acaaaguuug acuaacuuua 1620cacauuuuaa aaaugcugau ugucuucguu uaaauuauaa uuuuaccuau uucuugacau 1680cuaacuccua uuuauuucua uuauuuaaaa auuaagaaau gaaaauuugc uauuaacaau 1740aaaguuuuuu uaaugu 17561521113RNAHomo sapiens 152gggggggggg ggucagcgcc gacguccccu gccgccacca ugcccaaaag aaaggcugaa 60ggggaugcua aaggagacaa aaccaaggug aaggacgagc cacagagaag aucugcaagg 120uugucugcua aaccugcucc uccaaagcca gagcccaaac cuaaaaaggc cccugcgaag 180aagggagaga agguacccaa ggggaagaag gggaaagcug acgccgggaa ggaugcgaau 240aauccugcag aaaauggaga ugccaaaaca gaccaggcac agaaagcuga aggugcugga 300gaugccaagu gaugugugug cauuuuugau aacuguguac uucuggugac uguacaguuu 360gaaauacuau uuuuuaucaa guuuuauaaa aaugcagaau uucguuuuac uuuuuuuuuu 420uuuuuaagcu auauuguuag cacacagaac acuucauuac uggguggggg aaggaucaug 480ugucaguaac aaaaucucuc ccaagcugga uugaggacag aaaaccucuu ucccugauaa 540uuuuggaagg cuccuguugg cucccaggag agagauccug gucuugaccu agguggccac 600caaggcacaa caaugccuug uggucuggga aaacuauaaa uucacuuuua uauccucuuc 660ccccuguacu aucaacauag acuuaauucc cuuaaaaacc agagaccugu uggaaccugg 720cccccaaaau ugguuuccca guccauugag ugauggggac uuugcaguga cuucauugag 780uguucucaaa agagcacugg uuccuuuuau aaaagauugu ggaucuucag auugauaauu 840cugccuaaaa gucagggucg gcuugugaaa aguuguuaaa acaacauccu uaaugugaaa 900ugucaacccu cacucuaagc uacuuccccc uuuucaaagc auugaaugaa gacuucauug 960gguuuuauag uggcuuucug auuuugguag ucauaucaga agggaauuug gaaguucuug 1020uauauuguug cauugucugc ccauguccug ccugaauacc augauuguuu augaaagaau 1080cuuaauaaag cugguuacag uuaggcugga aaa 1113153321RNAHomo sapiens 153uuuuuuuuuu uuuuuuugga aguccauaag uaguuuauug ucuucaagac uacagugugg 60auuccucucc cagagaaggg ucuuucagag gcaggggacu gucacccagg ugcaggccgu 120cuacuuguca uuuucauaca uggcuggauu cuuccuuuuc gacugcucaa acuccugguu 180gccccaugug uagaucaggu agaccacuac aaacggcggc gccacgcgca ggaugcgcuc 240gcgagugcgg cgcaacacgu uggggaugcc uuugcugaaa uagcuuggga aggcgcgcug 300cucaaagggc gacaagcugu a 3211541720RNAHomo sapiensmisc_feature(952)..(952)n is a, c, g, or u 154caugaagcca gagaugugga agaugugucu agacugcauc aaugaacuga uggauacguu 60ggaugcacau uccaacaucu cugucggaga gaacauuuug gcagagagug agaacuuaca 120caacuuugau caguucacuc cguguacgac gcugcauccu aacuuuggug gagcgaaugg 180augaagaauu uaccaaaaua augcaaaaua cugauccuca cucccaagag uauguggagc 240accugaagga ugaggcacaa gugugugcau cauugagcga gugcagcgcu accuggagga 300gaaagguacc acugaggaga ucugccagau cuacuuaagg cgcauccugc acacguacua 360caaguuugac uacaaggccc aucagcggca cguuacuccu ccugaaggau ccucaaaguc 420ugagcaagac caggcagaaa augaggguga ggacucagcu gugcuaaugg aaagacugug 480caaguacauc uaugccaagg accguacaga ccggauccgu accugugcca uccucugcca 540uaucuaccau caugcgcucc acucccgcug guaucaggcc cgugaccuca ugcucaugag 600ccaccuacag gacaacauuc agcacgcaga cccgccggug cagauccugu auaaccguac 660uauggugcaa cugggcaucu gugcuuuccg ccaaggccug acaaaggaug cacacaaugg 720cacuucugga uauucaguca agugguggug ccaaggagcu ucuaggucag gguuugcugc 780ugcgcgcuug caggagcgaa aucaggaaca ggaaaaggua gagcgacgcc ggcaggugcc 840cuuucaccug cacaucaacc uggagcugcu ggaguguguc uaucuggugu cagcuaugcu 900ccuggagauc cccuacaugg cugcccauga gagcgaugcc cgccgacgca unaucagcaa 960gcaguuccac caccaacugc gggugggcga gcggcacgcc cugcuagguc cucccgaguc 1020aaugagggag cauguggucg cugccuccaa ggccaugaag augggcgacu ggaagaccug 1080ccacaguuuc aucauuaaug aaaagaugaa ugggaaagug ugggaccuuu ucccugaggc 1140ugacaaaguu cgcaccaugc uaguucggaa gauccaggaa gagucucuga ggaccuaccu 1200uuuuaccuac agcagugucu augacucaau caguauggag acacuaucag auauguuuga 1260gcuggaucua cccacuguuc acuccaucau cagcaagaug aucauuaacg aagaauugau 1320ggcuucccug gaccagccga cacagacugu ggugaugcac cguacugagc ccucugccca 1380gcaagaaacu uggcucugca agcuggcuga gaaaacuugg cacccuagug gagaauaaug 1440gacggguguu ugaccaaaaa cagggaaccu augguggcua uuuccgagac cccaagggug 1500gcuaccggaa aaauggaggc uaaaugcccc gugguggcua cccccagcaa cagucucaga 1560caaccuccug aguuccccac uucagucacc cuguggacag accaucuaac cuuuuucucc 1620uaacucaccc caaucauuaa agaucuuuug aggaauuaaa aaaaaagaaa gaaaaaaaaa 1680aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1720155453RNAHomo sapiens 155uuauuaauua aaaaacaauu uauugaaaaa gaguagugcu uuguacaaau ucccauugca 60gcccccagau aucaacugau cucuuuccag cuuugguagu aggguauaaa aauaucaaaa 120cuagguaagu ucugauguaa gauuucuaug ggauuauuuu agaauauaua gauuugugua 180guuuggcaag uaucauuucu augcauuuac auuacauauu aagcacagau ucuguggcaa 240aacaucuuug caugauuacu uuacacacac aaauauagua aaacuuacau aguacaaauu 300cacauaagac uccauucugu cuauaacuuc auccaugugg uuuuaccaug aauuauaauu 360cuuaaccucu ccuauaacug ucagcuucca uuuaauuuug aaaguaucac uucacaaaga 420gcacuucauu ugcuuuuaga guauacauag acu 453156361RNAHomo sapiensmisc_feature(230)..(230)n is a, c, g, or u 156cggccgccaa gaaguauaac augcgagugg aagacuacga gccauacccc gaugauggca 60ugggguaugg cgacuacccg augcucccca accgaucaca gcaugagagg gauccguggu 120aucaguggga ccacucagaa cucaggauga acugggguga accgauacac ugggaccuag 180acauguacau caggaaucgu guggacacgu caccuacccc uguguccugn gaugucaugu 240guaaacaucu cuucggcuuu guggcuuuca ugguuuucau guucugggua gggcacgugu 300ucccuuccua ccagccugug gguccgaagc aguacccuua caaaaaucug uaccuggagc 360g 361157452RNAHomo sapiens 157uuuuuuuuuu uuuuuuugau gcaaaugucu uuauuuucca cuuaaacaag uuucccuuuu 60gcacuggccu guggcacaaa acagauggcu ggguggugac auuaacuguc aaguuaguga 120gaugcagaga uggugagaca cugcauuuga gugcauaaua cuuuuauucc agaggaacgc 180caugcagccc aguuacaccu uuaggucaga aaggcugaug cgugaccagc cucuauugcc 240ucccuuggua agaaggaccc acaagugcag aguccaacag augcuggcuc ugagcugaac 300ucagggcauu ccaauuacca cuuucuucuu caccuacaca gggccugcuc agauguccuu 360uuuacaacuc cauaagcccu uuggccaaag ucccugcagu guuuggggag gaccuuccca 420cccuucacca gucagugucu gaucuggugg ag 452158392RNAHomo sapiens 158uuuuuuuuuu uuuuuuuaau aucuguaaua guuuauuuca aagauuugac auuuacaagu 60agaggcacca caugcuaucu gacaguaaaa uacugcaggg acugaaggcc aaggagagag 120auccacagaa gacaggccug uagugcaggc auugcaucga ccuugcccac agugcuuugu 180ucccaacuca ggacaguacu uuagugcuug cuucauuuac uggaaaaguu cacuggacau 240aguuuccacu ucuuccccca cagcuuccag cucagcaaac uuaagcuacu acuccucgau 300gcucucauag aggcucuuga uuugugucug gaagaacuug gcaagcucua cucguuuggc 360uuucaguguc ggugucagaa guccguuuuc aa 392159217RNAHomo sapiens 159uuuuuuuuuu uuuuuuucug agguauuaaa auaucuagac ugaauuuugc caaauguaag 60agggagaaag uuccugaaga cucugacuac uugcuuauuu uugauugacc uucuaugcuu 120augucauuac ugccucacaa cguguuugau guccuuuaau gauacaaagu gagccugugc 180cuucauuuuc uugcccauuu ugguaccccu cgugccg 2171601515RNAHomo sapiens 160gcgcccgaac gucuagcaga guaccugcug cuguaagcuu gucgucuggg cugcaccgcc 60cgucuuaacc cauucucgac uuaacuacuc ucgucgaaca agcauggaag uacagaaaga 120agcgcagcgc aucaugacuc ugucgguaug gaagauguac cacucucgca ugcagcgagg 180uggcuugcga cuccaccgga gucugcagcu aucccucguu augcgcagcg cucgagagcu 240cuaccucuca gccaagguag aagcccacca gcccgaguuc ccgccauccc gcagggcucu 300ugacccucgc cugcacccgc cgcgggaagc cgaaguugca guggaaguag cgucccccga 360agccgugcag ccuccggagc ccauggauac gcaagaggaa gugcugcgag uccaggagac 420cccugcgcuc ugugacccgc cccccgcuag agucagccgc aagcgccgga gcagcagcga 480uuugagcgac aguagugaug ccggacuggu accaagcaag aaggcccguc uagaagaggu 540ggagggggag gcgacgucgg agguucccga ucgccugcag cuuccuccgg cacaaagcga 600aggugccuuc ccuaaccucg cccgcguccu ccaaaggcgc uucuccaguc uccugaacug 660uggacccgcc gugcccccgc cgacgccccc cacgugcgag gccaagccag ccugccgccc 720ggccgacaau augcucaacg ugcuggugcg agcuguggug gccuucugag agcucuggug 780gcuucuuucg agcggcgcca ccggagcgga gaacgcacac ccgaggcgaa ggccggcggg 840ggccgugaag aagagccgcg gcccgagcug ccgagaggcc agggcaagga cugaggagcg 900aggggcgcgg gcgccuucuc ccagacgugc guccauaggu gcuauuaaag gacugucccu 960uccuuggcuu ggagaaggga caccuagauc uugaaucuca gggucgaacu cucuaggggc 1020caggcugccc uuucaaggcc guuucacuac cauucgcguu ucggccccua caagugggca 1080cgcuugugca agcggucaga guugcgucau gggacagacg cgggugcuuc cuguugccuu 1140gcgugggugu ggggccuggg aggaggccag gguguggacc cgcccuaggg acugggaagu 1200gacuugaguc accucgcccc cacaggcugc ugugggugag ccugaacuga accaaucaaa 1260ucugcgcaga guugaagugg cuggagaccc cgggacuggu caaccuagau gaucgccugg 1320cguggaccac cgcgggacgg gugggccgcu ggucguaguu gcugccguag acacagcuuc 1380uucgggcagg aaagaaaauu uuuuuuuuac cagcguguuu aagaaagucu guuuacuuuu 1440cccacggugg guuguuuaau uagcaacuac cuggaguuuu acaaugucag cuaggaaaau 1500aaagaccauc ggugu 1515161801RNAHomo sapiens 161cugagaggcc aggugggcgg cgaaaucaac guggagaugg augccgcucc cgguguggac 60cugagccgca uccugucaga gaugcgugau caguacgaga agauggcgga gaagaaccgc 120aaggaugccg aagacugguu cuucagcaag accgaggagc ugaaccgcga gguggccacc 180aacagcgagc uggugcagag cggcaagagc gagaucuccg agcucaggcg caccaugcag 240gcccuggaga uugagcugca gucccagcuc agcaugaaag caucucugga gggcagccug 300gcagagacag agaaccgcua cugcgugcag cugucucaga uccaggggcu gaucggcagu 360guggaggagc agcuggcuca gcugcgcugc gagauggagc agcagaacca ggaguacaag 420auccugcugg augugaagac aaggcuggag caggagaucg ccaccuaccg ccgucugcug 480gagggagagg augcccaccu gacucaguac aagccaaaag aaccugugac cacccgccag

540gugcgcacca uuguggaaga aguucaggau ggcaagguca ucucaucccg ggaacaggug 600caccagacca cccguuaagg acucagcucc uuccgcccag uuccccgagg cugcagagag 660gcagcuuccc ucuccgcucc ggcaucaccc uccugcuaca gccucucccc agcauuccua 720ugcuugagac cauuaaagcu ugcugaccug aagugaacug uggccuuugu ucugaacacu 780gaaauaaaug accaugguga c 801162447RNAHomo sapiens 162uuuuuuuuuu uuuuuuuggu uccacuuaag uugcauguuu uauuucuccc aaucccagca 60auagcacaga agcccaucau guccauccca gacugguuuc uaguaggcug agaugacagg 120gagccucagu aacgcuaaug gcacagaggg cucccaaaug ccaggcacaa cugugccucc 180acacugguga cugcccagag ugcccuggcc ccaguguguu ggcacucagu cugacuuuac 240aacgcaaccu gcaccuuuga aagggacagu cugggagugg ggagugugag ggagugaagc 300ucaaacugcc uccugucagc ucacccuuuc aacauuaaac agagaccaag agagaaacag 360uuccaauauu ucacauauau uucuucuugu gcagucuaag ccgagaaugc cauguaaaug 420ggucacugcg aaaugcagca auuuagu 447163475RNAHomo sapiens 163gucucgggcg agauggcuuc aagguuacuu cgcggagugg gcgcuuuggc ggcgcaggcc 60cugaggcgca cggcccgugg cgcggccgug acccgcucca uggcuucugg 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1140ccauagucaa acuucaccuu aauuucgaca ugacuuuugg aagcaggaag aaagcuacaa 1200aacugguauu ugguaccaug ugugagccug guuaaauugg ucuucuaaaa gcugucaauu 1260aggacauucu gcgaaaggua acaucacaac ugguucuaag ucaaaccauc aagucaacag 1320cagggugccu gagauaaucu uggaagcuua uugugcuggc cugcaccaga agauaucugc 1380auucucauua cuaaaauugu agcacagaac ugcacuagga uuuguuuaca aggagaaauu 1440aaacucuguu ugguuuucac auauagcagc ucuguuaaau aacaugcauc ugaauuuuaa 1500guugcaaagg uaucugaaca guuaauuuuu caugugcauc uuuuguugaa uguuuugguu 1560caagaaagaa uguuuaaagc uuuuuaaaga cuucaguucu uaauguaacu guacccuucu 1620gcauggaaaa ucauaaccaa cauggcugca guagacuucu uuagugguau ccagcaccac 1680uugcagaggg cugcuuuauc auauuguacu uggguguagg acucuagugu ucuugggugu 1740auugcauggg cugcauuauc uacagcauug uacaauaaca acuagaaaag gcgguauacu 1800ucacugaugc uugucuggua auaucacuuc uguguuaaaa uggaagguuu uuugugaugu 1860augaaacuug uguuuuuuau auauaaauga guauaguuag auuaguguug ugguaaugcc 1920uguuuucauc uguaaauagu uaaguaugua cacaacaagg cacuacuucu gauuuuugca 1980guguucaguc 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aggcgcuggu gucgguaugg 240cugcagugca ccgccaucag cagaaucuac acagugggcg ccagcuucga gggccgggag 300cuccugguca ucgagcuguc ugacaacccc gggguccaug agccggguga accugaauuu 360aaauacaucg ggaacaugca uggcaaugag gcgguuggac gggaauugcu cauuuucuug 420gcccaguacc uguguaacga guaccagaaa ggcaaugaga caauugucaa ccugauccac 480agcacccgaa uucauaucau gcccuccuug aaccccgacg gcuuugagaa agccgcaugg 540cagcccgggc agcugaagga cugguuugug ggccgcagca acgcccaggg aauagaucug 600aaccguaacu ucccagaccu ggacaggauc guauauguua augagaaaga aggcgguccc 660aacaaccacc ugcugaagaa ucugaagaaa auuguggacc aaaauucaaa gcuugccccc 720gagaccaagg cugucauuca cuggaucaug gacauuccau uugugcuuuc ugccaaucug 780cacggaggag accuuguggc uaauuaccca uaugaugaga cacggagcgg uacugcucac 840gaauacaguu ccugcccuga ugacgcaauu uuccaaagcu uggcucgcgc guacucuucu 900uucaacccag ucaugucuga ccccaaucga ccucccugcu gcaagaauga cgaugacagc 960agcuuugaug auggaacgac caaugguggu gcaugguaca gcguccccgg uggaaugcaa 1020gacuucaauu accugagcag cagcaacugc uuugagauca cuguggagcu uacgugugag 1080aaguucccac cugaagagac ucucaaaagc uacugggaag auaacaaaaa cucccucauc 1140aacuaccugg agcagauaca ccgagguguu aaaggguuug uccgugaccu ucaggguaac 1200ccgaaugcca acgcaaccau cucuguggau gggauagacc augaugucac cucggcuaag 1260gauggggauu acuggcgauu gcuugcuccu ggaaacuaua aacuuacagc cuccgauccu 1320ggcuaccugg caaucacaaa gaaaguggca guuccuuuua gcccugcugu ugggguggac 1380uuugagcuug agucuuucuc ugaaaggaag gaggaggaga aggaagaauu gauggagugg 1440uggaaaauga ugucagaaac uuugaauuuu uaagaaaggc uucuaacuaa uugcuuucau 1500cuaucuauag acuguaguaa gaugcaaugu ggcucuuuuc uuuuagguug ugugcaguug 1560auauuuaaca uugauuuauu uuugaucauu aaguaauagu uacuaaucac guaaauacac 1620ccggacagaa auauaaugcu ggacaucuuc auucuacauc aacauucgcu uaaaucauuc 1680gaagccucuu uuaacguaau gggugacaau gucacuugac agaugcauga gagucacgau 1740auagcugacu gugacccugc acugcaauca cauaguucca uauaaguugu ccuuagucuc 1800uugugcugau ucacuguaua agcaugaucc ugguaaugca cuuuggaugg gaagaaaaug 1860uacgugcuuu ucagaggggc ucugaacaga augaaaaccu aguucuugcg uguacuuuga 1920agaauggaau uguauuaguc agcuguuaau gccacuucag aaguuugggg uuuugucuug 1980auuguagauu gg 19921701828RNAHomo sapiens 170gccacggacg ccucucugaa cggggaucca ggcaggauua gagcugccuc acugacuaca 60ggccgugucg ugucaccguu ucugcaggca ccaugagcca ggacaccgaa guggacauga 120aagaugugga gcugaacgag cuagaaccgg agaagcagcc caugaaugca gcggacgggg 180cggcggccgg ggagaagaac ggucugguga agaucaaggu ggcggaggac gagacggagg 240ccggggucaa guucaccggc uuauccaagg aggagcuacu gaagguagcg ggcagcccug 300gcugggugcg cacccgcugg gcgcugcugc ugcucuucug gcucgguugg cugggcaugc 360uggcgggcgc cgugguuauc aucguucggg cgccgcgcug ccgugagcug ccuguacaga 420ggugguggca caagggcgcc cucuaccgca ucggcgaccu ucaggccuuu guaggccggg 480augcgggagg cauagcuggu cugaagagcc aucuggagua cuugagcacc cugaagguga 540agggccuggu guuaggccca auucacaaga accagaagga ugaaaucaau gaaaccgacc 600ugaaacagau uaaucccacu uugggcuccc aggaagauuu uaaagaccuu cuacaaagug 660ccaagaaaaa gagcauucac aucauuuugg accucacucc caacuaccag ggccagaaug 720cgugguuccu cccugcucag gcugacauug uagccaccaa aaugaaggaa gcucugaguu 780cuuggcugca ggacggugug gaugguuucc aauuccggga ugugggaaag cugaugaaug 840cacccuugua cuuggcugag uggcagaaua ucaccaagaa cuuaagugag gacaggcuuu 900ugauugcagg gacugagucc ucugaccugc agcaaauugu caacauacuu gaauccacca 960gcgaccugcu guugaccagc uccuaccugu caaauuccac uuucacuggg gagcguacug

1020aaucccuagu cacuagguuu uugaaugcca cuggcagcca auggugcagc uggagugugu 1080cgcaagcagg acuccucgca gacuuuauac cggaccaucu ucuccgacuc uaccagcugc 1140ugcucuucac ucugccaggg acuccuguuu uuagcuacgg ggaugagcuu ggccuucagg 1200gugcccuucc uggacagccu gcgaaggccc cacucaugcc guggaaugag uccagcaucu 1260uucacauccc aagaccugua agccucaaca ugacagugaa gggccagaau gaagacccug 1320gcucccuccu uacccaguuc cggcggcuga gugaccuucg ggguaaggag cgcucucugu 1380ugcacgguga cuuccaugca cugucuuccu caccugaccu cuucuccuac auacgacacu 1440gggaccagaa ugagcguuac cugguggugc ucaacuuccg agauucgggc cggucagcca 1500ggcuaggggc cuccaaccuc ccugcuggca uaagccugcc agccagcgcu aaacuuuugc 1560uuaguaccga cagugcccgg caaagccgug aggaggacac cucccugaag cuggaaaacc 1620ugagccugaa uccuuaugag ggcuugcugu uacaguuccc cuuuguggcc ugauccuucc 1680uaugcagaac cuaccacccu ccuuuguucu ccccaggccu uuuggauucu agucuuccuc 1740uccuuguuuu uaaacuuuug cagauuacau acgaauucuu auacugggug uuuuugucuu 1800caaauaaaaa caucaccccu gccucaug 18281712610RNAHomo sapiensmisc_feature(2)..(2)n is a, c, g, or umisc_feature(11)..(11)n is a, c, g, or umisc_feature(26)..(26)n is a, c, g, or umisc_feature(41)..(41)n is a, c, g, or umisc_feature(45)..(45)n is a, c, g, or umisc_feature(56)..(56)n is a, c, g, or umisc_feature(70)..(70)n is a, c, g, or umisc_feature(2262)..(2262)n is a, c, g, or umisc_feature(2276)..(2276)n is a, c, g, or umisc_feature(2288)..(2288)n is a, c, g, or umisc_feature(2290)..(2290)n is a, c, g, or umisc_feature(2298)..(2298)n is a, c, g, or umisc_feature(2309)..(2309)n is a, c, g, or umisc_feature(2311)..(2311)n is a, c, g, or umisc_feature(2324)..(2324)n is a, c, g, or umisc_feature(2333)..(2333)n is a, c, g, or umisc_feature(2335)..(2335)n is a, c, g, or umisc_feature(2412)..(2412)n is a, c, g, or umisc_feature(2418)..(2418)n is a, c, g, or umisc_feature(2435)..(2435)n is a, c, g, or umisc_feature(2447)..(2447)n is a, c, g, or umisc_feature(2462)..(2462)n is a, c, g, or umisc_feature(2475)..(2475)n is a, c, g, or umisc_feature(2483)..(2483)n is a, c, g, or umisc_feature(2493)..(2493)n is a, c, g, or umisc_feature(2513)..(2513)n is a, c, g, or umisc_feature(2523)..(2523)n is a, c, g, or umisc_feature(2535)..(2535)n is a, c, g, or umisc_feature(2552)..(2552)n is a, c, g, or umisc_feature(2555)..(2555)n is a, c, g, or umisc_feature(2566)..(2566)n is a, c, g, or umisc_feature(2590)..(2590)n is a, c, g, or u 171gncuuaagcc ncguuuauuu ugaugnccug uuggcucagu naugnccaag augccnauug 60uuuuugcccn aaauaaauuu acugaacuug ggcuaaaacc aaaccuuggc acacaggugu 120gauacaacuu aacaggaauc aucgauucau ccauaaauaa uauaaggaaa aacucaagug 180guagccuguc uuaaggcuuu ugauacuugc agauugggga aaaacaaaca acaaacgucu 240ugaagcauau uaauggaauu aguuucuaau guggcaaacu guauuaaguu aaaaguucug 300auuugcucac ucuauccugg auagguauuu agaaccugau aauagucuuu aaacaagcca 360uuccagucau gaugagguga uguauggaua caugcauaca uucaaagcac uguucucaaa 420guuaaugcaa guaaauacag caauuccucu uucaauguuu aggcagaucg uuaacuauga 480gcuagccaaa ugugggcaug uuauuacagg gaaaguuuaa aggucugaua acuugaaaua 540gguuuaggag aauucaucua cuuagacuuu uuaaaugccu gccauaaaaa auugaaaugg 600uagaauggcu gaccacagca augaccagcc cucaccuagg gcucuggaug auuuuugguc 660uaauaacgca ugcuaguguu gauguuuuuu ggucaagaug ggaaugaaca ggaagaauua 720ugcagcaggc uuuauuuuaa augccgauuc acauuacucu guucaagcug cguugagaug 780uuaaacuggc uuacuauaga cuuuguaaaa aaaaaaaaaa ccaaacaaau ggcuccagaa 840gaguaacaaa cugaaaucug agaucacaca gguuggaaau auguacauaa cugaacaagg 900ugucaauucu gcucuacagu gcaguuuagu caguuuuagu ugcauagguu uccauuguuu 960uuauagucug uuuaugcuaa aucuggccaa agaugagcau uguccaccac uaaaaugccu 1020augccacugg gaauucuggg uuaauuuugu gaccagaaug cagugaucaa aauguucaau 1080cuuuuuacag uggcauagga agauggcaaa aauuuccuaa agugcaauag auuuucaagu 1140guauugugcc uuguucuaaa acuuuuauua aguaggugca cuugacagua uugaggucau 1200uuguuauggu gcuauuucaa uuagucuagg uuuaggcccu uguacauuug gcccauaacu 1260uuuuacaaag uacuucuuuu auugcacauu cagagaauuu uauauauaug ucuugugugc 1320guguccuuaa acuuccaauc uuauuuuguc ucuuggagau uguugaacgc agcuugucua 1380ggaaagggau gggacuagau ucuaaaauuu auuugggacc augggaauga uaguugggaa 1440gaaacuuugc acacgacaga uuucuagaua cuuuuugcug cuaguuuuau guaauauuua 1500uugaacauuu ugacaaauau uuauuuuugu aagccuaaaa gugauucuuu gaaaguuuaa 1560agaaacuuga ccaaaagaca guacaaaaac acuggcacuu gaauguugaa ugucaccgua 1620ugcgugaaau uauauauuuc gggguagugu gagcuuuuaa uguuaaguca uaauaaacuc 1680uuaagucaaa uuaagcagac ccggcauugg cguguagcca uaacuuucug auguuaguaa 1740aaacaaaauu ggcgacuuga aacuaaauca ugccaagguu ugauacacuu gucuugagau 1800auuaacgaaa cacuuccaaa cacugauaca aaguguccag auucucagau guuuguugug 1860ugaguuuugu uuaguuguau uuuuuuuuca gugaaugucu ggcacauugc aauccucaaa 1920caugugguua ucuuuguugu auuggcauau ucagugacuu guacauucag caauagcauu 1980ugagcaaguu uuaucagcaa gcaauauuuu caguuauguu uccaaauuaa gaauggguuu 2040aaacuugcug aauguaaaga uugacccuca agucacugua gcuuuaguag uugcuuauug 2100uauuaguuua gaugcuagca cugcaugugc ugugcauauu cugguuuuau uaaaauaaaa 2160aguugaacug cacagucucc uuuguuguug ucaauugugg uuuacuuuua gaggugaaaa 2220uaaaguugug cucuugccuc gugccaauau guacauaacu gnacaaggug ucaauncugc 2280ucuacagngn aguuuagnca guuuuagung nauagguucc caunguuuuu aungncuguu 2340uaugcuaaau cuggccaaag augagcauug cccaccacua aaaugccuau gccacuggga 2400auccuggguu anuuuggnga ccagaaugaa gugancaaaa uguccanucu uuuuacagug 2460gnauaggaag auggnaaaaa uunccuaaag ugnaauagau uuccaagugu uungugccug 2520guncuaaaac uuuunuuaag uagggugcac unganaguau ugaggncauu gguuauggug 2580cuauuuccan uuagucuagg uuuaggcccu 26101723657RNAHomo sapiens 172cucggucucc aagauggugg cuaacaaaac gugaggccua gagguugauc cuaggucacu 60ggaagcaugu ccuugaagag gacuaugggc aucuggguuc uuccucuucu acuuggccac 120gagguaaccg gcuucuugua ccacgugugc ucaccucuac aaucugugcg gauucagacu 180ccaagcaacu aggcuaccca gugacaggcu aaaaacuaca gcucuaacgu cuuggaaggc 240gauuccaugg accaggaugu ggaaagccca guggccauuc accagccaaa guugccuaag 300caggccaggg acgaccugcc gagacacauc agccgagaca ggaccaaaag gaaaauccag 360agguacguga ggaaggaugg gaagugcaac guucaccacg gcaaugugcg ggagacguac 420cgauaccuga cggacaucuu caccacccug guggaccuga aguggagauu caaccuguug 480aucuuuguca uggucuacac agugacgugg cuuuucuuug ggaugaucug guggcugauu 540gcguacaucc ggggagauau ggaccacaua gaggaccccu cguggacucc uugugucacc 600aaccucaacg gguuugucuc ugcuuuuuua uucuccauag agacagaaac caccaucggu 660uauggcuacc gggucaucac ggacaagugc ccugagggga uuauucuccu cuuaauccag 720uccguguugg gguccauugu caacgccuuc augguaggau guauguuugu gaaaauaucc 780caacccaaga agagggcaga gacccugguc uuuuccaccc acgcggugau cuccaugcgg 840gaugggaaac ugugcuugau guuccgggug ggggacuuga ggaauucuca cauuguggag 900gcauccauca gagccaaguu gaucaagucc aaacagacuu cagaggggga guuuauuccc 960cucaaccaga cugauaucaa cgugggguac uacacagggg acgaccggcu cuuucuggug 1020ucaccauuga uuauuagcca ugaaauuaac caacagaguc ccuucuggga gaucuccaaa 1080gcgcagcugc cuaaagagga acuggagauu guggucaucc uggagggaau gguggaagcc 1140acagggcagu ucugaaaucg aaaucaagca gaggucuaua agaacacccu ggagaccccc 1200augcugcugg aucuuggguc caugaacugc uuuuauuugc ugcaaucaaa aaugcuaguc 1260gcugaucuga uaggagagga aacgagacuc agagccugaa ggauaacacg cugagggcug 1320auuucauaca cucuucccgg cuggaucauc ccagccccca cagcguccag gcuuaguuuc 1380uuccuuuguu uuaacaaucu auacuuccuc cagccugggc gagcuaguau acccagaguu 1440ugguuuuguu ucuuuucaga gcuguaagcc cagugcccag ugaccucauc ugggaggaga 1500guuaagcaau aagaccugaa augcuaaacu cugggguaga aaaccucugc agagacagcg 1560ucucugggaa gucucuacag agacagagua gggaagucuc acgaagguca gagucuuacu 1620uccauaccug gagaaauccg cccguccguu cagugccggu uucaacuccu cugccaaaga 1680cuucuuucca agacacuggu aucagcuauc ccagcaguaa cuuuggcagu auauaaauca 1740auggcacugc cccauaaaac cccguugagu aaaaccuaug gucuucaaca gcuggggagc 1800cuguagccca gcuccugugu gaggcuaagg cuguggagac caugccugcu caccuccucg 1860uugaaaagca aaacacugua agaaaccuaa caugacuuuu uccaacauuu cucaggcugg 1920ggagaagacu ugguccacaa agagcuugag gucuugaucu ggaucccuag cauccaugga 1980agaagguggg caugaucacc cacacuccuc aucccauagc ucugaaugag guaggcagau 2040uccuggggcu caccagcuca uccuaacagc caggucccaa ugagggacug ucuacaaaag 2100aacaagaggu ggauccugag aagcgacacc caagcuugac cucuagcccc uguacacacc 2160uguuaagcac cugggcaucg ggacacacac ucgcaauuug caaacaaggc aaauucucac 2220acuucagaag gcacugagag aaucccauaa gcucaaaaag uuaggagcca agauugacca 2280uuaaugacuu ggguugaaaa gacuaaacca cuggauagaa uguuucauua cuaaaacacc 2340uuaccugaaa aguauuacug cucuucuuuc ugcaacugga ccaugcagag auccacaaag 2400agaugcccag agauuauuag ugauggucau augauauaca caauguggac ucuaagccaa 2460ggccccauca acucagaucc agaggcugac agugugcuua ucuuagagau accacagugg 2520cugccuaauc accacguccu uaagucaggg gaguuugauu auuuccuaug aacaccgagu 2580ggggacagcg gauuaccaau gaagcaaucc aaccugacaa uccuaaccac ccagaagagg 2640aucgcugggg gaaagcauga auuauuuacg ugucaacaug ugcacacucc ggccacgcag 2700cucaacagcc aggagugcuu cuccacuuag cccugcccug gcauccauuu augaucucgu 2760cuguuguguu aauuacccag cuagcuuuuu ucucaaaaau aauaucuccc agccauagac 2820cuacucaucu guguccucuu uaauuucaac ccacaguuac aucauucacu ggcuugcuca 2880guuucuucaa cucugaaaug ggaaugauga ugaugaugcc ucuuccccca agccaccauc 2940cucccccgug accuuccuag guacagacuc aaaccaggga agauuauuuc cuucucauag 3000gccacagggu gaaaugcaau aaagaacaaa gccuuguagg gaggcagagg gaaagaccag 3060uccucacaag aggcuccauu guuuccaggg acuuugaagc uuggacagaa ugucagauga 3120uccccuuuga aggugcucca aagagucaau gugaaaaaua uugacugaug ugugcccguc 3180cacaagccaa ggugccucug cccuggucac cuaccaugaa uuauaaacug augauauuug 3240aaauaauaag gaacacugga gccggccaga aaggauucug cagucccaua aauagcaaca 3300uucaucacua caaugccugc caacgguggc cgugaaugua gauuaccccc ggcucuucug 3360aggccacuga ggacagggca aacuaccucu gagaauggag gcucacuguu cugcauccca 3420cuucuaaaug uuccaugaau uuuuugagac aucucccaua ucccuguuag aaagauucaa 3480ccuugugcua uuaaccaaau cauuuugaau uccauaaacc ucuacucuaa aguauacacu 3540uaauucuaca auacagacaa caaauaugac uuuuuccuau gaaagaguga uaaagauacu 3600guaucagucu gcuuugacuc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 36571732267RNAHomo sapiens 173uggaaugggu gcuaggugaa ggcuuuguug aaucaggaug cugagcuggu guuuuuacag 60guccagauau gaugagcugg aguuuuggua ggcccaggua ccuccuccaa aauugaccac 120auaauugguc acaaaucagg ccuccacaga uacaaaaaua uugaaauuau cccaugcauc 180cugucugauc accacagacu aaggcugauc uucaauaaca acauaaaaau agaaagccag 240guucacugcu gcggcugcgc cuccuuguuc ucagcgucac cacugccgcc augcccggag 300gguugcuucu cggggacgaa gcccccaacu uugaggccaa uaccaccauc ggccgcaucc 360gcuuccacga uuuccuggga gauucauggg gcauucucuu uucccaccca cgggacuuua 420ccccagugug caccacagaa cuuggcagag cugcaaagcu ggcgccagag uucgccaaga 480ggaauguuaa guugauugcu cuuucaauag acaguguuga ggaucaucuu gccuggagca 540aggacaucaa ugcuuacaau ggugaaacac ccacggaaaa guugccauuu cccaucauug 600augauaaggg cagggaccuu gccauccuuu ugggcauguu ggauccaguc gagaaggacg 660auaacaacau gccugugacg gcccgugugg uguucauuuu uggcccugac aagaaacuga 720agcugucuau ccucuacccu gccaccacga gcaggaacuu ugaugagauu cucagagugg 780uugacucucu ccagcugaca ggcacaaagc cgguugccac cccaguugac uggaagaagg 840gagagagcgu gaugguaguc cccacccucu ccgaagagga agccaaacaa uguuucccua 900aaggagucuu caccaaagag cucccgucug gcaaaaaaua ccuccguuau acaccccagc 960cuuaagucuu ugcggaaauu ggggcugcau cugcacgucc agcacugggg ccugaggacg 1020ucagccggca gccguggguc cuugcagcag guccguagaa agaucguggc augaucacag 1080ccgguccugu agaucgcucg cuauacuacu gggucauuaa auggaaaugg caccaaaacc 1140uucucgggau ucuuuacucu gugccuucgc cagcauucug ccccucugcc ugucacagug 1200cccuacugac uggcucucuu ugaaacgaau uauguauuga agauuccuua ggucucugca 1260gggucuuuga ucagcaagca agguaguguc agugugggcu cugugcuaga augaugaaac 1320accuuuugua gcuuuccgaa cggaaucuuc uguuacccau uuuggagagc acugacaugg 1380ggagaagcuu ucaauucugu auuuuuagua aauaaagugg ggacagccgg gagaauucuu 1440acagggaauc uauuguaagu uucuaucgaa gugggcucag aaagccuuuc gccucccaag 1500agugcgcaug uaccuccuag aguuuccaca ucugcucucu ggugaugucu gccugugaac 1560gcaccuuaua aaagacgggc ggugacagug uuuuaccacu caguguccua guagugggug 1620gccauuucug aauucugcuu uuugagguuc aacaaauaaa auccugauca gaaaaaaaaa 1680aaaauagaaa gccaacauuc auguggaaac ugaacaacac uacucaauga uuccuugguc 1740agagaugaaa uaaagaaaga aauuaaagac uuuuuagagu uuaaugaaaa ugaagccaca 1800acauacccaa acuuauggga cacaaugaag gcauuucuaa gaggaaaacu cauagcccug 1860agugcaucca aaggaaaaaa aaaaaaaccu agagagagug uacacuagca gccugacugc 1920acacuuagaa gcucugcaaa aaaaggaauc 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2580uggagccucu gggcuccuac cgggauugug uugcuggcuu uaccaauauu accuacaacc 2640uucagaauga cggccucauc aauggggaug agagcuaugu gucuuucagu ccauauucag 2700aggccguguu cuugccccag gauccaggug ucaucugcgg agcaguguuu ggauguaucu 2760uuggugcccu ggccaucaca gcugugggag gcuucaucuu cuggagaaag aaaaggacag 2820augccaagaa uaaugaagug uccuuuucuc aaauuaaacc uaaaaaaucc aaguuaaucc 2880gaguggagaa uuuugaggcc uacuuuaaga aacagcaagc ugacucuaac uguggguuug 2940cagaggaaua ugaggaccug aagcugauug ggauaaguuu accuaaauac acagcugaga 3000uagccgagaa cagagggaag aaccgcuaca acaauguucu gcccuaugau auuucucgag 3060ucaaacuuuc aguccagacc cauucgacag augacuacau caaugccaac uauaugccug 3120gcuaccauuc caagaaagau uucauugcca cacaaggacc uuuacccaac acuuugaaag 3180auuucuggcg uaugguuugg gagaaaaacg uauaugccau uguuauguug accaaaugcg 3240uggagcaggg aaggaccaaa ugugaggagu acuggccuuc caagcaggcu caggacuacg 3300gggacauaac uguggcgaug acaucagaag ucguucuucc agaauggacc aucagagauu 3360uuguggugaa aaauaugcag aauagcgaga gccauccucu gcggcaguuc cauuucaccu 3420ccuggccuga ccacgguguu ccugacacca cugaccugcu caucaacuuu cgguaccugg 3480uccgggauua caugaagcag auaccccccg agucaccaau ucuggugcau ugcagugcug 3540ggguuggaag gacgggcacu uucaucgcca ucgaucgccu gaucuaucag auagagaaug 3600agaacaccgu ggacguguau gggauugucu augaccuucg gaugcacagg ccucugaugg 3660ugcagacaga ggaccaguau guuuuccuca aucagugugu uuuggauauu aucagagccc 3720agaaagacuc aaaaguugau cucaucuauc agaacacaac ggcaaugaca aucuaugaaa 3780accucgagcc aaguuccuug aaugugacua uguugcuuca uccacagcug aacgauuuug 3840gauguugggu ucuagguccu ggcuguugcu ggucugcuag gauccagggc cuuguugaca 3900ucugggaaga uguaaauugu cccgcugaag gccgcaguuu uagauguggc cacuagaugg 3960agccagagca cugguaugaa ggagcaccag ggccguguaa ggcaaaagag gacccagaaa 4020aagaaacuua acuuguucac uccugagaaa ccugcaaguc aacaagccaa ggaagugccu 4080uugcaugcau uugguagccu uuccaauccc gcuuauuaca uaauauguuc auguucaugg 4140caaaaaaaaa aaaaauaaaa uaaaauaaau aaaaaaggaa aacaaaauaa aaaaaaucuu 4200agaacauu 4208186249RNAHomo sapiens 186gcccccucaa gggcauccug ggcuacacug agcaccaggu ggucuccucu gacuucaaca 60gcgacaccca cuccuccacc ugacgcuggg gcuggcauug cccucaacga ccacuuuguc 120aagcucauuu ccugguauga caacgaauuu gcuacagcaa cagggugugg accucauggc 180ccacauggcc uccaagguaa gccccuggac caccagcccc agcaaggcac aagaggaagg 240agagacccu 249187410RNAHomo sapiens 187uuuuuuuuuu uuuuuuucau auuaaacuug uaguuuuauu cagguuugau uuuuaacaaa 60ugugucaggg agagagccca caggaaaggg uaaagcccgu gggggcaagg ccuucccaga 120ugccugagga gggaucgugu ccccuccccc ccuccucuuc ucaccacccc uacagggguu 180ugggaagaga cacaggcagg gaaggggcug guccccaguc uguacagugg ugcuuggggg 240ugaaggacua uggagaacag gggaccagau cggggaugag uaggauaaag ggcacaagac 300cauuuaccag aauccagcuu ucugauucca aauugaauua aaaagaaaaa aaggagaggg 360gaaccuaaac cacaagcagu acccaacucc cuuuccccca ucagggcugc 410188382RNAHomo sapiens 188uuuuuuuuuu uuuuuuuagg gaagaggcug augccagaua aguuuuuauu auauuaaaaa 60aaaaaaaaaa accagugcaa cuggaaauca gggugagucg cuggagguga gugagagucg 120gaaggcccuc cacaccucag ugguggcagg aucuggaccc guagccuaag ccuggucuga 180uccagccgag augcuggaaa gcagagcaca cgguggugcc caucagggca aagagggcaa 240gagagcccac ggcuccucca uaccgcuugc uagggucucc uguguaguag ccauaugcgu 300aaaggacucg cccaauaauc caggccaggc ccaggccaga agcuaugcgc gggugguaaa 360caccucccac cguuaggaaa aa 382189253RNAHomo sapiensmisc_feature(32)..(32)n is a, c, g, or umisc_feature(41)..(41)n is a, c, g, or u 189cggccgcgug aguuuugacu gagcuucugc angaaguuca naugcaacuc cauacaucag 60uucauuuucu agcauuacca cuggguuauu aucacgaaug gccgauuuaa uaaguccuuu 120ugcauccucg gaauuccagg ggcugaccac uuuuaaaccu gggcagugcc cauaccaugc 180agcaaagcau ugcgagugcu gagcagcuac accugcugag gcgccauugg gcccccugaa 240uacuaugggc aca 253190371RNAHomo sapiens 190uuuuuuuuuu uuuuuuugaa gggccauugg aguuuauuua cagacaaccu uaggugaggc 60cuuuuccucu aggaucuaca ugcuuuugaa guuacuuggu uucaggcuuc uugucuccag 120cuucgagcuu gagacucuca ggaggcuggc gauaggcagg gaaagccucc caggggcugu 180ucaggucaaa cuugcggaau ucuugugcca gcuccacugg uucagccacu acccgcuuua 240ccucaucguc guaacgaagc ucaacauagc cagugagggg aaagucuuuc cggaaaggau 300gucccucgaa gccauaaucu 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auucauuaaa gccugcuaau 1320gaagaccaga aaauagguau agaaauuauu aaaagagcac uuaaaauucc ugcaaugacg 1380auugcuaaga augcaggugu ugaaggaucu uugauaguug agaaaauucu gcagaguucc 1440ucagaaguug guuaugacgc caugcuugga gauuuuguga acauggugga aaaagggauc 1500auugauccaa caaagguugu gagaacugcc uuacuggaug cugcuggggu ggccuccuug 1560cuaacuacag ccgaagcugu agugacagaa auuccuaaag aagagaagga cccuggaaug 1620ggugcaaugg guggcauggg aggggguaug ggaggcggca uguucuaacu ccuagaguag 1680ugcuuugccc uuaucaauga acugugacag gaagcucaag gcagguuccu caccaauaac 1740uucagagaag ucaccuggag aaaaugacug aagagaaggc uggcugacca cuguaaucau 1800caguuacugg uuuccuuuga cgauauauaa ugguuuacug cugucauugu ccaugccuac 1860agauaauuua uuuuguauuu uugaauaaag aacauuugua cauuccugau gcugguugca 1920agagccauau accagugucc ugcuuucaac uuaaaucacu gaggcaucuc uacucuucug 1980ugagucauca ggacuguagc gcugugucaa caaaacauag agaguucaga agacagccuu 2040ucuguggaag ggugggaaug auuguguaca aaguagagaa guauccaauu augugacaac 2100cuuuguguaa 21101931228RNAHomo sapiens 193acagccgcau cuucuugugc agugccagcc ucgucccgua gacaaaaugg ugaaggucgg 60ugugaacgga uuuggccgua uugggcgccu ggucaccagg gcugccauuu gcaguggcaa 120aguggagauu guugccauca acgaccccuu cauugaccuc

aacuacaugg ucuacauguu 180ccaguaugac uccacucacg gcaaauucaa cggcacaguc aaggccgaga augggaagcu 240ugucaucaac gggaagccca ucaccaucuu ccaggagcga gaccccacua acaucaaaug 300gggugaggcc ggugcugagu augucgugga gucuacuggu gucuucacca ccauggagaa 360ggccggggcc cacuugaagg guggagccaa acgggucauc aucuccgccc cuucugccga 420ugcccccaug uuugugaugg gugugaacca cgagaaauau gacaacucac ucaagauugu 480cagcaaugca uccugcacca ccaacugcuu agccccccug gccaagguca uccaugacaa 540cuuuggcauu guggaagggc ucaugaccac aguccaugcc aucacugcca cccagaagac 600uguggauggc cccucuggaa agcuguggcg ugauggccgu ggggcugccc agaacaucau 660cccugcaucc acuggugcug ccaaggcugu gggcaagguc aucccagagc ugaacgggaa 720gcucacuggc auggccuucc guguuccuac ccccaaugug uccgucgugg aucugacgug 780ccgccuggag aaaccugcca aguaugauga caucaagaag guggugaagc aggcaucuga 840gggcccacug aagggcaucu ugggcuacac ugaggaccag guugucuccu gcgacuucaa 900cagcaacucc cacucuucca ccuucgaugc cggggcuggc auugcucuca augacaacuu 960ugucaagcuc auuuccuggu augacaauga auacggcuac agcaacaggg ugguggaccu 1020cauggccuac auggccucca aggaguaaga aacccuggac cacccacccc agcaaggaca 1080cugagcaaga gaggcccuau cccaacucgg cccccaacac ugagcaucuc ccucacaauu 1140uccaucccag acccccauaa uaacaggagg ggccuaggga gcccucccua cucucuugaa 1200uaccaucaau aaaguucgcu gcacccac 1228194723RNAHomo sapiens 194agaagcuucc uaaggaacaa gcaaguugaa uagagaaaau agugaucaau aauaggcauu 60uuaguggucu uuuuaauguu uucugcugcg gaacauuuca agauuuauug auuuccuccu 120ccccccauuu uuuucccacc acacucacac acgcacgcuc acacuuuuua uuugccauaa 180ugaaccgucc agccccugug gagaucucuu augagaacau gcguuuucug auaacucaca 240accccaccaa ugcgacucuc aacaaguuca cagaggaacu uaagaaguac ggagugacaa 300cuuugguucg aguuugugau gcuacauaug auaaagcucc aguugaaaaa gaaggaaucc 360acguucuaga uuggccguuu gaugauggag cuccaccccc uaaucagaua guagaugauu 420ggcuaaaccu guuaaaaacc aaauuucgug aagagccagg cuguuguguu gcagugcauu 480guguugcagg auugggaagg gcuccugugc uaguugcgcu ugcauugauu gaaugcggaa 540ugaaguauga agaugcuguu caauuuauaa gacaaaaaag aagaggagca uucaauucca 600aacagcugcu uuacuuggag aaguaccgac 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guggccacag guggcgcuca ucagcguauc 780ccuuccagaa ucucacacgc ugcaguggau guacggcugc gacguggggc ccgaugggcg 840ccugcuccgc ggguauuguc aggaggccua cgauggccag gauuacaucu cccugaacga 900ggaccugcgu uccuggaccg cgaaugacau agccucacag aucucuaagc acaagucaga 960ggcagucgau gaggcccacc aacagagggc auaccugcaa gguccuugcg uggaguggcu 1020ccauagauac cuacggcugg gaaaugagac acugcagcgc ucaggugccc uggagagcuc 1080uccucacuuu uccucugcgg uuugggggaa auccuugagg uauaaccuca ggggcagaac 1140gcuguucagc gggcacagcg cggaggagga gggagaggga cucccaaaac ugcuuuuccc 1200cuguagggau ucuaauccuu aacaaaagca gaucaggcuc gacaauggcc cuggacccau 1260ggggggaggg ggcucuuucu caggccuccc uccuugcccu acucaguguc ucuauaguca 1320gacuccagcu uuucucaauc ucuuggcccu cauccagcuc aggaccagaa gcccuuccca 1380ugagucugca gagaccugga gccuccuguc cauguugucc ugcucacauc cuaaggcauc 1440ccuaagagca gauccuccca ggugcaggug cucuagcugg ugucuagaug auggacacca 1500uaaucccacc gcaguccucc uguccacccc aggacgguca caugaacacu gcugaguccc 1560cagaagaaag caagaugccu cauccuuuca acucucuccc ucagacccuc caaaggcaca 1620ugugacccau cacccuagau cugaagauga agucacccug aggugcuggg cccugggcuu 1680cuacccugcu gacaucaccc ugaccuggca guugaauggg gaggagcuga cccaggacau 1740ggagcuugug gagaccaggc cugcagggga uggaaccuuc cagaaguggg cagcugucgu 1800ggugccucuu gggaaggagc aguauuacac augccaugug uaccaugagg ggcugccuga 1860gccccucacc cugagauggg guaaggaggg ugugggugcu gaacuggggu cagggaaagc 1920uggagccuuc ugcagacccu gaguugguca uggcucagag cugggaucau aacccucacc 1980uucauuuccu guaccugucc uucccagagc cuccuccauc cacugucucc aacaugguaa 2040ucauagcugu ucugguuguc cuuggagcug ugaucauccu uggagcugug guggcuuuug 2100ugaugaagag gaggagacac auagguagga aagggcaggg ucugaguuuu cucucagccu 2160ccuuuugcag ugugcucugc uccuuaaugg gaaacauagc cacacccaca uugcugcagu 2220cuccaacugg gucagcuguc aguuccggga acucccuagg gcugguguuu cucuggucuc 2280ucauggcuuu ucuucucaca gguguaaaag gaugcuaugc ucauguucua gguaagugcg 2340agagaggggc aggggacacc cuugucccug aggcucucag gauggagcug ggauuuguuc 2400cagcccauaa ucuccucuug ccacauccuc ucugucuccu cugugugccu uguuaucucu 2460ucuacugcag gcagcaagag cuuccagacc ucugacuggc cucagaaggc augaaaaucc 2520cugggggggc uggugagaug gcucaguggg uaagagcacu gacugcucuu cugaaggucc 2580agaguucaaa ucccagcaac cacauggugg cucacaacca uccguaacga gaucugacuc 2640ccucuucugg agugucugaa gacagcuaca auguacuuac auauaauaaa 2690196269RNAHomo sapiens 196uuuuuuuuuu uguucccuug aaagccagau guuccaaaaa guagccugcu ccauuguucu 60ucucagucuc auagcgacug ccagcgucaa uccacacucc caccgugcag guagcaugcg 120aggacugcuc cgaggccaca cgcagcccgu uguccaagau gcugaccugg gucuccggca 180cgcucuggag ggccugggcg aagguugcgg uaccccgcaa ggcagguaac cucagcaggg 240ccggcgagcg gcgggugcgc cucgugccg 2691971335RNAHomo sapiens 197ggugcuuaau guuuugaccu guagaggucc ucacuuuucg ucauggcgcu gaagguggcg 60auagcugcug gcggugcugc aaaggcaaug cucaagccaa cucuccucug ccguccuugg 120gagguucugg cugcccaugu ggccccccga aggagcauuu ccucacaaca aacaauuccu 180ccaucugcua aguauggugg gcggcauaca gugacuauga ucccagggga uggcaucggc 240ccagagcuca uguugcaugu uaagucugua uucaggcaug caugugugcc gguggacuuu 300gaagaggugc auguaagcuc caacgcugau gaggaggaca uccgcaaugc caucauggcc 360auccgccgga accguguggc ccugaagggc aacauugaaa caaaucauaa ccugccacca 420ucccacaaau cucgaaacaa cauccuucgc accagccuag accucuaugc caacgucauc 480cacuguaaga gccugccagg aguggugacc cggcacaagg acauagacau ccucauugua 540cgggaaaaca cagaaggcga guacagcagc cuggagcaug agagcguagc aggaguggug 600gagagcuuga agauuaucac caaagccaag ucccugcgca uugcugaaua ugcuuucaag 660cuggcccagg agagugggcg uaagaaagug acggcugugc acaaggccaa caucaugaaa 720cugggugaug gacucuuccu ccagugcugc agggaaguag cagcccacua cccucagauc 780accuuugaca gcaugauugu agacaacaca acaaugcagc ugguaucccg gccucagcag 840uuugauguca uggugaugcc uaaucucuau gguaacauug ucaacaacgu cugugcaggg 900cuaguuggag gcccaggccu uguggcuggg gccaacuaug gccaugugua ugcaguauuc 960gagacagcua caaggaacac aggcaaaagu auugccaaua agaacauugc uaacccgacu 1020gccacacugc uagcaagcug caugaugcua gaccaccuca agcuccacuc cuaugccacu 1080uccauccgca aagcugucuu agcauccaug gacaaugaaa auaugcauac cccagauauu 1140ggaggccagg gcaccacauc ccaagccauc caggacauca uucgucauau ccgcaucauu 1200aauggacggg cuguggaggc uuagcuaucc cuacaguuuu gcucagcuug ucuguaggac 1260ucucuucuca cuuuagcacu ccagcuagcu ugggggacag gacccagaau aaagccacuu 1320cuguuccaga aaaaa 1335198382RNAHomo sapiens 198uuuuuuuuuu uuuuuuuguu cuuaauagaa aacuuuauuu ucacugauaa ugucacugua 60acauaauuuc auagcagacc ugugcaaaag aucccacauc accaaugucu ccaagagauu 120ucacacacuu cugggcagga cgcacagcuc ugcccccacc cccguguuga cagucaacau 180uuuacccccg cuaugaguac agaaaggcga ggcaucauaa cgaagccgcc ugaaggcagc 240gugagcugaa gucggacgcu ugccaccucu gaaugaaugg ucaccacagc aacagcacau 300gguugccuca gugugcucag ggugggucuu ugaaaaaacg ucccacuaug uaaauaugcu 360gcacuuaucc cuucaacauu gu 3821991992RNAHomo sapiens 199ggcagacaaa agaggccggc agugcagcuc gcgggacgca uggccgggcg cggaggacgg 60gugcugcugg cgcugugugc cgcgcuggug gccggcgggu ggcugcugac gcgugaagcc 120caggagcccg gggcgccagc ggcuggcaug aggcgccgcc ggcggcucca gcaagaggac 180ggcaucuccu ucgaguacca ccgcuaucca gagcugcgcg aggcgcuggu gucgguaugg 240cugcagugca ccgccaucag cagaaucuac acagugggcg ccagcuucga gggccgggag 300cuccugguca ucgagcuguc ugacaacccc gggguccaug agccggguga accugaauuu 360aaauacaucg ggaacaugca uggcaaugag gcgguuggac gggaauugcu cauuuucuug 420gcccaguacc uguguaacga guaccagaaa ggcaaugaga caauugucaa ccugauccac 480agcacccgaa uucauaucau gcccuccuug aaccccgacg gcuuugagaa agccgcaugg 540cagcccgggc agcugaagga cugguuugug ggccgcagca acgcccaggg aauagaucug 600aaccguaacu ucccagaccu ggacaggauc guauauguua augagaaaga aggcgguccc 660aacaaccacc ugcugaagaa ucugaagaaa auuguggacc aaaauucaaa gcuugccccc 720gagaccaagg cugucauuca cuggaucaug gacauuccau uugugcuuuc ugccaaucug 780cacggaggag accuuguggc uaauuaccca uaugaugaga cacggagcgg uacugcucac 840gaauacaguu ccugcccuga ugacgcaauu uuccaaagcu uggcucgcgc guacucuucu 900uucaacccag ucaugucuga ccccaaucga ccucccugcu gcaagaauga cgaugacagc 960agcuuugaug auggaacgac caaugguggu gcaugguaca gcguccccgg uggaaugcaa 1020gacuucaauu accugagcag cagcaacugc uuugagauca cuguggagcu uacgugugag 1080aaguucccac cugaagagac ucucaaaagc uacugggaag auaacaaaaa cucccucauc 1140aacuaccugg agcagauaca ccgagguguu aaaggguuug uccgugaccu ucaggguaac 1200ccgaaugcca acgcaaccau cucuguggau gggauagacc augaugucac cucggcuaag 1260gauggggauu acuggcgauu gcuugcuccu ggaaacuaua aacuuacagc cuccgauccu 1320ggcuaccugg caaucacaaa gaaaguggca guuccuuuua gcccugcugu ugggguggac 1380uuugagcuug agucuuucuc ugaaaggaag gaggaggaga aggaagaauu gauggagugg 1440uggaaaauga ugucagaaac uuugaauuuu uaagaaaggc uucuaacuaa uugcuuucau 1500cuaucuauag acuguaguaa gaugcaaugu ggcucuuuuc uuuuagguug ugugcaguug 1560auauuuaaca uugauuuauu uuugaucauu aaguaauagu uacuaaucac guaaauacac 1620ccggacagaa auauaaugcu ggacaucuuc auucuacauc aacauucgcu uaaaucauuc 1680gaagccucuu uuaacguaau gggugacaau gucacuugac agaugcauga gagucacgau 1740auagcugacu gugacccugc acugcaauca cauaguucca uauaaguugu ccuuagucuc 1800uugugcugau ucacuguaua agcaugaucc ugguaaugca cuuuggaugg gaagaaaaug 1860uacgugcuuu ucagaggggc ucugaacaga augaaaaccu aguucuugcg uguacuuuga 1920agaauggaau uguauuaguc agcuguuaau gccacuucag aaguuugggg uuuugucuug 1980auuguagauu gg 1992200210RNAHomo sapiensmisc_feature(118)..(121)n is a, c, g, or u 200gauccuguau auguguguuu ugggggagcu augauaaguu uuauggcaaa cgguugguau 60uguuaacuuu uuauugucau caaaaguuca uaaaaguccu auuaaucccc auauucunnn 120ncugcccuua acucugguau acaccaaaaa gaaaucuuua cuuuccuugu uuuaucauua 180uaaaaauaaa guauuuugcu aguauggaaa 210201677RNAHomo sapiens 201aguccgcguc ccggcgucgg cccgucccgc accaugguga cgcucgccga gcugcuggcg 60cugcuggccg cgcugcuggc cacggccucg ggcuacuuug ucagcaucga cgcgcacgcc 120gaggagugcu ucuucgagcg ggucaccucc ggcaccaaga ugggccucau cuucgaggug 180gcggagggcg gcuuccugga caucgacgug gagaucacag gaccagauaa uaaaggaauc 240uauaaaggag accgggaguc cagcgggaag uacacauuug cagcccacau ggaugggaca 300uacaaguucu gcuuuagcaa uaggaugucc acuaugacuc caaagauagu aauguucacc 360auugacauug gggaggcucc caaaggacaa gacauggaga cagaagcuca ucagaacaag 420cuagaagaaa ugauuaauga gcuggcagug gcaaugacag ccguaaagca cgaacaggag 480uacauggaag uccgggagag aauacacaga gccaucaaug acaacacaaa cagcagagug 540guccuuuggu ccuucuucga agcucuuguu cuaguugcca ugacauuggg acagaucuac 600uaccugaaga gauuuuuuga aguccggagg guuguuuaaa aggccuuuuc cuguugaucc 660caaauucaug auuuacu 6772022849RNAHomo sapiensmisc_feature(2158)..(2158)n is a, c, g, or u 202gcauuggcuc ugggcugcgg ccggcucggc gacgcuccuc gggcagcuca cugcaugguc 60gucuggugcc cccgccgccu gcauccccgc cgccgccccg cgacgcccac cgccgccugc 120ccugccgccg ccgccugcgc cgccucggga ccggcuguau gauuaggcca caaucuucaa 180ugaguagaca uauuccucag uucuguggug uucucgguca cacauuuaug gaguuucuga 240agggcagugg agauuacugc caggcacagc acgaccucua ugcagacaag ugaacuguag 300aaauucauua cuacuccacc aagaaacccc cauaagagug gauaaccugg acacaggcgu 360guugaauuga aaucugcaca gcauuugaga agagcucaga ccuggauggg guaaaccuca 420gugccacuuc cuuuguauug ccucuaguau uacugggauu gaagagucac ugcuucuugu 480uuaggagguu cauuucauug gcccguuucu cccaauuuca uacucaagca cugagaauuu 540caaguggagu auaucgaaua ucgaaguaga cuucagguug uuuuuugguu uuguuuuguu 600uuuuuuuugu uuugguuuuu uuuuuuuuuu ucuguuuugg uuuaaaucau uucuguauuc 660aauuuuuuaa uucuuucaua acccuauugg guguuuuuuu 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1560cuauaaggaa uuuagaagga uuaggugcca aaauacccag cacaauacuu guauauuuuu 1620agcaucauac agaaccaaaa uugcaggaac ugagaacucu cagaccaucc augguguauu 1680ccuucaguca uuucaaacac ugcagggcuc cucucguuau cugccugcuc acucuguuua 1740caucucccac acuuaugcca gaauacguca gguuugcuua gccauccuuu auuuuuuuua 1800uuuuuuuuuu uaacuaaguc uugcgcugau uauuuaauau gucugucuca uuuuguuuug 1860uuuugggaaa ccucugucug aaaaaucaac uuuguuacag aagcacauau cuucaacaau 1920gucuccagac aaaaagccuu auaguuaauu uaauguuugc acucagaagu gcaaccuaac 1980agggagggcc ugaaaaagaa acgagaggag gcuauuaaau auuuuuagua auauguugcc 2040uuugucaugu gcagaacaug uagaguaugc ucuuaauuua guaaauauuu uuaagacaua 2100gagauacaug uguagcuaac ccauucuuau ucaaaauucu ggaauuuugu guuuuccnau 2160accuaucagg aaguuuccag cuuguuugaa uuauggcuuu ccucuuccca aucucuugca 2220aaaaagacaa agugggauga aucugcuagu gaacugagca gaaauguuuu auaacgccuu 2280uugagcuaug uaacuuaaua auuggauacu ugaucauuug uuuuauuaug uaaucggaua 2340aaauggugau guguauuaaa guuaguucaa ccauauauuu auacugucug ggaaugugug 2400guuauaguuc 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gaagcugcgc gggcgcgagc 420caguuggggc acuggguggg cggcggcgac agcggcgcca cgcgcaggcu ggaggccgcc 480gaggcucgcc augccgggag aacucuaacu cccccaugga gucggccgac uucuacgagg 540uggagccgcg gcccccgaug agcagucacc uccagagccc cccgcacgcg cccagcaacg 600cccgccuuug gcuuuccccg gggcgcgggc cccgcgccgc ccccagcccc accugccgcc 660ccggagccgc ugggcggauc ugcgagcacg agacgucuau agacaucagc gccuacaucg 720acccggccgc cuucaacgac gaguuccugg ccgaccucuu ccagcacagc cgacagcagg 780agaaggccaa ggcggcggcg ggccccgcgg guggcggcgg ugacuuugac uacccgggag 840ccccggcggg ccccggcggc gcggucaugu ccgcgggggc gcacgggccc ccucccggcu 900acggcugugc ggcggccggc uaccuggacg gcaggcugga gccccuguac gagcgcgucg 960gggcgcccgc gcuacggccg cuggugauca aacaagagcc ccgcgaggag gacgaggcga 1020agcagcuggc gcuggccggc cucuuccccu accagccacc gccgccaccg ccaccgccgc 1080acccgcacgc gucucccgcg caccuggccg ccccccacuu gcaguuccag aucgcgcacu 1140gcggccagac caccaugcac cuacagccug gccaccccac accgccgccc acgcccgugc 1200ccagcccgca cgcugcgccc gccuugggug cugcgggccu gccuggcccc gggagcgcgc 1260ucaagggcuu ggccggugcg caccccgacc uccgcacggg aggcggcggc gguggcagcg 1320gugccggugc gggcaaagcc aagaagucgg uggacaagaa cagcaacgag uaccggguac 1380ggcgggaacg caacaacauc gcggugcgca agagccgaga uaaagccaaa caacgcaacg 1440uggagacgca acagaaggug cuggaguuga ccagugacaa ugaccgccug cgcaagcggg 1500uggaacagcu gagccgugaa cuggacacgc ugcggggcau cuuccgccag cugccugaga 1560gcuccuuggu caaggccaug gcaacugcgc gugaggcgcg cggcugcggg accgccuugg 1620gccggccccc uggcuggaga cccagaggau gguuucgggu cgcuggaucu cuaggcugcc 1680cgggccgcgc aagccaggac uaggagauuc cgguguggcc ugaaagccug gccugcuccg 1740cguguccccu cccuuccucu gagccggacu cggugcgucu aagaugaggg agucaggccg 1800uggugguuuc uccuugagac cgagagacuu uuccgcggag cugagcuggg ggcccggcag 1860uacuaguauu aaggaaguaa ccuugugccu uggauacuca aaacucgcuc cuuuuccuac 1920cgaguagggg gagcaaaaau gugccuugau auuuuauuug gaggauuccu gcuuccucuc 1980gggccucagc uggcccccgu gagaaaaaug aagggugcag gcccagggca ggaggaagau 2040acaggaagcu gagaucccgg cagugcccug agcugccccu cagucccugu cuuuagaggg 2100gagggacuua gguguugggg auuugagucu guguccucac ccccagcuac agggaggugg 2160agggcuccua aucccuugcu uuuugcaccu ccaccuacau

cccccccccc ccacucagcu 2220uacaacaggc cagguuuccu gggugaguuc auggagaaug ggggcaccac ccccagucag 2280acagaaagcu gaguugugag uuagccaugu gguaggagac agagaccuag guuucugggc 2340uuuguggggu gggggauagg aggacacggg gaccauuagc cuugugugua cuguaugucg 2400ccagccgcug uugcugaagg aacuugaagc acaaucgauc caucccagag ggacuggagu 2460uaugacaagc uucccaaaua uuuugcuuua ucauccgaua ucaacacuug uaucuggucu 2520cuguguccca gcggugccuu gugcaauggc agugugcacg ucuaugcuaa accaccauuu 2580uauuuggucu uuuguuuugu uuugguuuug cucugauucu ugccaaacug agacucuuca 2640cuaacggcug ggggaaggag cugagugagg cucucauucu uuuugguuua gggauguuug 2700gguuuuuucg ucugccuccc agaggaccaa ugaaaugaag ugggcuuccc ccucuccccu 2760aguuguccaa ggguguaugu aguagugggu cuuagcuucc uccggcuaag acuuaggcuu 2820ccccacccac ccaaccccau ccccaacggc ccuggcucug ggucuggaaa gaaggccacc 2880uccagccagu ucauacacac accccugugg cugggagcag ggcuggaccg cuuccuucuc 2940uucuuuuuuu gggggggggg acacaaaguu ucaugcuaga ugucguaugu auuauaucua 3000uaauauaaac auaucaaacu caa 3023204380RNAHomo sapiensmisc_feature(76)..(76)n is a, c, g, or u 204gaagcucagu gucgugaaau ggaaaccaaa ccuuggagcc aucgcugagu auaaaaaaaa 60ggaagauuua uauucngcaa agaguagccg aacuggacaa aauuacuucu gaaagagaua 120auuuuagaca agcauaugaa gaucuucgaa aacaaaggcu gaaugaauuu auggcugguu 180uuuacguaau aacaaauaaa cuaaaagaaa acuaccagau gcucacauug ggaggagaug 240cugaacugga gcuuguggac aguuuagauc cuuuuucuga aggaaucaug uucaguguuc 300ggccaccuaa gaaaaguugg aagaagaucu uuaaccucuc aggaggcgag aaaacccuua 360guuccuggcc uuaguguuug 3802051391RNAHomo sapiens 205gccgguuuga guugugcgcu cggguguccc uuuccucuuc cccucccgca gggcuugcgg 60ccaccauggc guauuagagg cagcagugcc ugcggcagcg uuggccuuug cagcggcggc 120agcagcacca ggcucugcag cggcaacccc caccggccua agccauggcg cucuucacga 180aauccagcag caguguugcu guaacggaca aagauaccuu cgaguuaagc acauuccugg 240aauccagcaa agccccacaa caugaccgag augagcuucc ugaacagcga aguguuggcg 300ggggacuuga ugucccccuu cgaccagucg gguuuggggg cugaagaaag ccuaggucuc 360uuagaugacu aucuggaggu ggccaagcac uugaaaccuc auggguucuc cagcgacaag 420gcgggcuccu cggaauggcc ggcuauggau gauggcuugg ccagugccuc agacaccggc 480aaggaggaug ccuuuuccgg gacagauugg auguuggaga aaauggaucu gaaagaguuu 540gacuucgaug cucuguuucg aauggaugac cuggaaacca ugccagauga gcucuugacc 600acguuggaug acacauguga ucuuuuugcc ccucuagucc aagagacuaa uaaggagccc 660ccucagacag ugaacccaau uggccaucuc ccagaaaguu uaauaaaagu cgaccagguu 720gcccccuuua cauucuugca gccuuucccc uguuccccag ggguucuguc uuccacucca 780gagcauuccu uuaguuuaga gcuaggcagu gaaguugaua ucucugaagg agacaggaag 840ccugacucug cugcuuacau uacucuaauc ccuccaugug uaaaggagga agacacuccc 900ucugacaaug acaguggcau cuguaugagc ccggaguccu accugggcuc uccccagcau 960agccccucca ccuccagggc cccaccagac aaucugccuu cuccaggugg uucccguggg 1020ucuccucggc ccaaaccuua ugacccaccu ggaguuaguu ugacagcuaa agugaagacu 1080gagaaauugg auaagaagcu gaaaaagaug gagcaaaaca agacagcagc cacuagguac 1140cgccagaaga agcgggcuga gcaggaggcc cucacuggcg aguguaagga gcuagaaaaa 1200aagaaugagg cucugaaaga gaaggcagau ucucuggcca aggagaucca guaucugaaa 1260gaccugauag aagagguccg 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ggacugguaa 360gcuuuggagg gauccaucaa ggauuccccg accccacccc uaucgccagg gga 4132081707RNAHomo sapiens 208ccucugcggc gcgguccucg gagcggcgcg guucucggag ccacgcgucu gucuuccucc 60guggucaugg cggacuaccu gauuagcgga ggcaccucuu acgugccgga cgacgggcuc 120acagcgcagc agcucuucaa cugcggggac ggccucaccu acaaugauuu ucucauucuu 180ccuggguaua ucgacuucac ugcagaucag guggacuuga cgucugcucu aacuaagaag 240auuacacuaa agaccccauu gguuuccuca cccauggaca cugucacaga ggcuggaaug 300gccaucgcga uggcgcuuac aggagguauu gguuucaucc accacaacug cacaccugaa 360uuccaggcca augaaguucg gaaagugaag aaauacgaac agggauucau cacugacccc 420gugguccuua gccccaagga ucguguacgc gauguuuuug aggccaaagc caggcauggc 480uucuguggua uccccaucac agauacaggc cggaugggga gucgauuggu gggcaucauc 540uccucaaggg acauugauuu ccucaaggag gaagagcaug accgguucuu ggaagagauc 600augacuaaga gggaagauuu gguggucgcc ccugccggcg ucacucugaa agaggcaaau 660gagauucugc agcgaaguaa aaagggaaag uugcccauug ugaaugaaaa ugaugagcug 720guagccauca uugcccggac agaccuaaag aagaaucgug auuacccccu ggccuccaaa 780gaugccaaga agcaacugcu guguggggca gccauuggca cucaugagga ugacaaguau 840aggcuggacu uacuggcccu ugcuggugug gauguagugg uuuuggacuc uucccaggga 900aacuccaucu uccaaaucaa uaugaucaaa uacaucaagg agaaguaucc cagucuacag 960gucauuggag gcaauguagu cacugcugcg caagccaaga accucauaga ugcaggugua 1020gaugcuuugc gagucggcau gggaaguggu uccaucugca ucacccagga aguguuggcc 1080ugugggcggc cccaagccac agcaguguac aaggucucug aguaugcccg ucgcuuuggu 1140guuccuguua uugcugaugg aggaauccaa aauguggguc auauugccaa agcuuuggcu 1200cuuggggcuu ccacagucau gaugggcucc cuccuggcug ccaccacuga ggccccuggc 1260gaguacuucu ucucagaugg gauccggcug aagaaauacc gagguauggg uucucuugau 1320gccauggaca aacaucucag cagccagaac cgauacuuca gugaagcuga caaaaucaaa 1380guggcccaag gaguuucagg ggcagugcag gacaaggggu cuauccacaa guucguuccu 1440uaccugauug cuggcaucca gcauuccugu caagacauug gugccaagag uuuaacccaa 1500gucagagcca ugacguacuc gggggagcuu aaauuugaga agaggacauc cucugcucag 1560guggaaggug gcguccacag ccuccauucg uacgagaaac ggcuuuucug aaaacagauc 1620caguauaugc cuugaauuuu ucaauaaaag uuugggaaaa aaaaagugaa aaaaaaaaaa 1680aaaaaaaaaa aaaaaaaaaa aaaaaaa 1707209261RNAHomo sapiens 209gugugggugc agagcugggg ucagggaaag cuggagccuu uugcagaccc ugagcugcuc 60acggcugaga gcugggguca uuacccucac cuucauuucc uguaccuguc cuucccagag 120ccuccuccau ccacugucuc caacauggcg aacguagcug uucugguugu ccuuggagcu 180uggccaucau ugcagcugug guggcuuuug ugaugaagag aaggagacac acagguagga 240aagggcagag ucugaguuuu u 261210173RNAHomo sapiens 210acaggagggg aaggccaaag caagaaugaa agucccccgc cccguaucac cacgggcacu 60cggggucacc cucaggaaca ugcagucucu gcacgugagg aaagaaacac gcagagaugg 120acgagcacuu uuacacccua auaaaauuag augcacuaac cacagacccc ccu 173211494RNAHomo sapiens 211uuuuuuuuuu uuuuuuuaaa aaaaaaaaug gcaucuuuua uucaucaauc ccuguuacac 60acugaaauac augcaucuuu cuuauguuac uuagcaacgu ccuuucuauc cuuucaccca 120uaaaucaguc ugaugaauuc aucuuuaaau ucaagaaguu uuucuuuuug aaacgcuacu 180uacauuuuau ugucucaaua ucaaagccaa ucuagagauu uauucuuccu acaggugaaa 240uagauguuaa uacgggaaca gucaguacau guucaagaug acaucaaagu uaugcccuaa 300gcagauauuu caaggcaaua ucaugccacu agcucugaga cucuaaguau cacugauagu 360acuaaaaggu agaagucagc uucaaaaaca cacucuugca auggacacug cucaugaugu 420cuaagauugu ucacucccac agucaugauu ucagaugcac aguuuuuuuu gcuuuccuga 480gcauucgguu ugac 494212384RNAHomo sapiens 212uuuuuuuuuu uuuuuuuaag agugucacca aagcuuuauu uacaugcguc aucaucucuu 60uuacaaacua gauuaugguu uuaaauggaa uacacaggca auaucuacaa acgccacggg 120aaguacgcac cuccauucca ccgggaaggg gcagauuccc aaaucaaacu gguuuugauc 180cuugagaaga aaggcggcag agcuaacuca cggcagcgua ugguuagaca agguccucag 240uacccagaau gcagcaggau ugcgucugcc ucaaaccaga cgaccaacug cugcaggugu 300uuaaacaugg ccacgcgcca cacgaaauuc uaguuugugu gggguagaag caagaaaaaa 360aaaaaaccau ggcgccucgu gccg 384213982RNAHomo sapiens 213gguccggaua guaaacugcu cccuuacauc uccuuaaaua uaaaguaagg aaaaagaaaa 60aacucaguuc ggguaaccaa guucaacaag uaauccuugg ggccgcugug guaucgccaa 120aaucuacaua guaucucuua uuaaaauguu uugacgaaaa uguaacaauu acgguacuua 180augguaacaa uguggcugag gaagcaauag uuaacaaaga ggagcuaagc uaugcaacaa 240accagauuuc uauuggucac aaauuugaag uugagaccug uuauccaauu accaaguacu 300uccgcauaca ucaucauagg cauuugaaga uuucaaccaa ucaggagcau guuccuucua 360uaaaggaacc cagaaccuaa ccucugcauu uccuauuucu uuguagaaau ggcucguacg 420aagcagaccg cucgcaaguc cacuggcggc aaggccccgc gcaagcagcu ggccaccaag 480gccgcccgca agagcgcccc ggccaccggc ggcgugaaga aaccucaccg cuaccguccc 540ggcaccgugg cgcugcgcga gauccggcgc uaccagaagu cgaccgagcu gcugauccgc 600aagcugccgu uccagcgccu ggugcgcgag aucgcgcagg acuucaagac cgaccugcgc 660uuccagagcu cggccgucau ggcucugcag gaggcgagcg aggccuaccu ugugggucug 720uuugaggaca ccaaccugug cgccauccac gccaagcgug ucaccaucau gcccaaggac 780auccagcugg cccgccguau ccgcggcgag cgggcuuaau aggcacgcuu ucuacacugg 840cacguaaacc aaaacggcuc uuuuaagagc caccuccauu auccaccaaa gaugcuugaa 900guacaaguug ugagaguuuu cuaggguuuc cuauuauagc cuuucuugac aaugugagca 960ccacccgacg aagcagucug ag 982214424RNAHomo sapiens 214uuuuuuuuuu uuuuuuugga cuucugcggc uuuuauuuuu gcauguaaac cacugggggg 60agggggaucu ugaugguggg cacccuagag auuacacugg aguuccgagg gcuccagaca 120cuagcuggga agucagguga cagaaacaau gauucagacc aaucacauga uugcaaaacu 180gggucuccag cagggauucu gguggucagg uguggaugcc uaaggaagca gugacauggg 240aggggcacgc acugggcugg ccuugagcug cugggaugac aucagggaua gaggaccuag 300cagcuggugg cuccagggau cuccggucca ugcuuuauuu ggccaggggg uuccugaagg 360accugccagc aaacuuggcu uugcugccca gcucuuccuc aauucugagg aucugauugu 420acuu 4242151407RNAHomo sapiens 215auucuaagga ucaugucugc gagucaggau ucucgaucca gagacaaugg ccccgacggg 60auggagccgg aaggcgucau cgagaguaac uggaacgaga uuguggauag cuuugaugac 120augaaucucu cagagucccu ccuccguggu auuuaugccu augguuuuga gaagcccucu 180gccauccagc agcgagcuau ucuuccuugu aucaaggguu augaugugau ugcucaagcc 240cagucuggga cugggaaaac agcuacauuu gccauaucaa uucugcagca gauugaauua 300gaucuaaagg ccacucaggc uuugguucug gcacccacac gugaauuggc ucagcagaua 360caaaaggugg uuauggcauu aggagacuac augggugccu cuugucaugc cugcauuggg 420ggcaccaaug ugcgugcuga ggugcagaag cugcagaugg aagcucccca uaucaucgug 480gguaccccug gccggguguu ugacaugcuu aaccggagau accugucccc caaauacauc 540aagauguucg uacuggauga agcagaugaa auguuaagcc gaggguucaa ggaucagauc 600uaugacauau uccagaagcu caacagcaac acacagguag uuuuguuguc ugcuacaaug 660ccuucugaug uccuugaggu gaccaagaaa uuuaugagag acccuauucg gauucuuguc 720aagaaggaag aauugacccu ggaggguauc cgccaauucu acaucaaugu ggaacgagag 780gaguggaagc uugacacauu gugugacuug uaugagacgc ugaccaucac ccaggcaguc 840aucuuuauca acaccagaag gaagguggac uggcucaccg agaagaugca ugcccgagau 900uucacuguuu cugccaugca cggagauaug gaccaaaagg aacgagaugu gaucaugagg 960gaguuccggu cuggcucuag cagaguauua auuaccacug accuguuggc cagaggcauu 1020gaugugcagc aggucuccuu agucaucaac uaugaccuuc ccaccaacag ggaaaacuac 1080auccacagaa ucggucgagg uggucgguuu ggucguaagg guguggcuau uaacauggug 1140accgaagaag acaagaggac ucuucgagac auugagacuu ucuacaacac cuccauugaa 1200gagaugcccc ucaacguugc ugaccucauu ugaggggcug uccugcgacc uggcccuagc 1260ccaggguuca guccuggggu ggggcuaagg aagagcugga ggggggaggg gagggagcca 1320agggauggac aucuuguuuu uguuuuggcu uuuuuuuuuu uuuguuucag uuuuuuuucu 1380cuaugaauaa augucacuuu uugaggc 1407216562RNAHomo sapiens 216uuuuuuuuuu uuuuuuugcc aggauauauu uauuacugaa aguacaagca acugagguuu 60acccugggaa cacccacaau gaaacgugua ucuucccugu uucucagaug cugccuccuu 120ccacagagug aguuuucguu uaaaacucau aaugaggaga aggcaggggg cuccaccccu 180uuccuguuca aucugaagac ugaauugggc uacacuggga uggagauuuc aggugcugca 240ggucaguguc aaccaagggu ucguguguca ggaacucugg cugguaagau gacacaaagg 300cuucaugcug aagcucaggg agguccaggg agccuggcag aauggaauca ucauggucau 360caucaaacgu cugugucugg aaggcuucaa ggcucauaau ugcaucauuc ucuggcaguu 420ccugagagag cugccccuuc cuggguuugc acgcaucaaa uuucacccac ugguaauuga 480cacaguuuug agcuucggga caacucuuaa ucagguugug gaugguugga ugagaaaacc 540caaagaaguc ggcaccgcau ga 5622171238RNAHomo sapiens 217auuguaacag aagaaggaaa ggaaaagaaa guuaacauug acuuugaacc uuucaaacca 60auuaauacau cauuguauuu gugcgacaau aaguuucaua cagaggcucu uacagcguua 120cuuucagaug acagcaaguu ugguuuuauu guaauagacg gaaguggugc ucuuuuuggc 180acgcuccaag gaaacaccag agaaguccug cacaaauuca cuguggaucu cccaaagaaa 240cacggcagag gaggucaauc agccuugcgu uuugcccguu uaagaaugga aaagagacau 300aacuauguuc ggaaaguagc cgagacugcu gugcagcugu uuauuucugg agaccaagug 360aauguggcug guuugguuuu agcuggauca gcugacuuua aaacugaacu aagucaaucu 420gacauguuug accagagguu gcaaucuaaa guuuuaaaau uaguugauau auccuauggu 480ggugaaaaug gauucaacca agcuauugaa uuaucuacug aaguucucuc caacgugaag 540uucauucaag agaagaaauu aauaggacga uauuuugaug aaauuagcca ggacacaggc 600aaguacuguu uuggaguuga agauacacua aaggcuuugg aaaugggagc uguacaaauu 660cuaauagucu augaaaaucu ggauauaaug agauacguuc uucauugcca aggcacagaa 720gaggagaaaa uucucuauuu aacuccagaa caagagaagg auaaaucuca cuucacagac 780aaagagacug gacaggaaca cgaacugaua gaaagcaugc cucucuugga augguuugcu 840aacaacuaua aaaaauuugg agcuacacua gaaauuguca cagauaaguc acaagaagga 900ucacaguuug ugaaaggauu ugguggaauu ggagguaucu ugcgguaccg aguagauuuc 960cagggaaugg aguaccaagg aggagaugau gaauuuuuug accuugauga cuacuaggua 1020gucgacaugg guccggcaac cgugccucac ccuccagcau ucaacccaag gagcauaccc 1080gugguggagu ccaacagauc ccugccuuac aauuggagca uuuccagaac uuaauccgug 1140agcauuggau acugaaaaga aaagugaaac aaaaccagac ccaacccuac acuuugguuu 1200gucguggugu cagcgcagca gccgacaacu aagucucu 1238218464RNAHomo sapiens 218cagaggaguc auuguugcug ugguggcuuu ugugaugaag aggaggagaa acacagcgua 60agccagcugc cuggagugga cuaagugaca gacaaugucu ucacacaucu ccugugacau 120ccagagcccu caguuuucuu uagucaagua ucugauguuc ccugugagcc uaugggucaa 180agugaagaac ugugcagccc agccugcccu gcacacagaa cccugucccu gcacugcccu 240ggguucccuu ccacagccaa ccuugcugcu ccagccaaac acugggcgac aucugcaucc 300ugccagcucc augcugcccu gagcugcagc uccucacuuc cacacugaga guaagaaucu 360gaaugggacc uugauucuua acauccugac cgaggguuga uuucuuguua auuucaugga 420uugagaauac uuagaguuuu gguuugucuu gauuuuuuuu caag 464219841RNAHomo sapiens 219ugaauaaaaa cgaggagccg aagauucuag ggggcuacag cugcgcuuuu gcagcacuga 60acaugguucc ggguacucaa gauauugcgu uuguguuugg agagguguag auuguagauu 120ccagccgaga agaccaggaa aagauaagga uaaagaaugu cauauaucuc aggagcuaga 180ucacuucccg augaacaagu aagaauugcc ucaacaaaaa uggauggaau uggaccgaaa 240aaagccauuc agcuucguua ucgauuaggu aucaguggga acaucaagau gaaugaguua 300acuaaguauc agaucgacca aauugaacaa augauagcuc aagaucaugu uguucauugg 360gaauugaaga ggggagaacg agcagacauc gaacgauuaa uuucuauuuc ucguuaucgu 420ggaauucguc aucaagaugg aucgcccuua cgcggucaac gaacucauac uaaugcaagg 480acugcucgca agcaaauucg gaaaugaaag aaggcuaccg aaagaacaag caacggauuu 540cgcgcucauc ccuugcuaaa gcgcauacgu uuucuugcuc cuugguacuu gucugaucaa 600ucacacuguu cauuaguuca cuugauuuuu cguucgaugu cuugaaccgc uuacuaauca 660cguauacgua uaguaggccc ccuucgccac uccacgucug gcccgucuug gucucgcuca 720cuucgcccgc cuaucguauc ggcucggcuu cguccgucaa gcgacagcuu cugccucuga 780cggcuucacu aucgcucaug acugguagua cucuauguag uagucggccu uuguuaagcu 840u 841220136RNAHomo sapiens 220uauaaccaug uuagaagcgg aaguuggccu gaaaaccuga ggcuuaggcu ucauagcugg 60gcuguagauu ggauuuaaac ccaguuggag ugcaaaguca uggugugcuc aaggugauga 120cagugaacag aguaug 136221752RNAHomo sapiens 221caugggccuc cugagagauc cuuagaucca gguuagugca uaggaaagug uccccccacu 60accuacagcu aagggauugg ggugguggga ucauggugga gggccguggu gaauacuagc 120gauguccccc gcuacccgug cgucugccuc cagggugccc cuccaaccag gaugaggcuc 180uucaucgcuc uuccuguccu gauugugguc guagccauga ccuuggaagg uaagaaagag 240ccuuggaagg uaagaaagau gcuuggaagu gugaaguugg ccuugugccu gcggcccagg 300cuuagaagac ccucgaggag ggcucugagg ucccuuucug ugucaucauu ccacuaccgc 360ccucccaucg ucccccaucc caccugccag gugccuuauu uuugugucaa agugggugcu 420gaaggaggca acucugucca gaaaagacgc aguaaccaau gaccuaggau accacccuuu 480ggaauuggcu aaucuuccua gaaggggcgg acgguaaaaa caaggaggug agaggugcag 540uaaaaucaag uguccaauac ccucccccau gcuaaugagu uugcucgcaa cccucucgcg 600gcaggcccag cccccgccca ggcggccccg gauuuguccg gaacauugga gagcauaccg 660gauaaacuga aggaguuugg gaacacuuug gaagacaagg cccgggcagc cauugaacau 720aucaaacaga aggaaauuuu gaccaagacc cg 7522222858RNAHomo sapiens 222cagcgccugg ggcgcggcgg gcgucggccc aggagacgcg uggcggcgcu cggccucgcg 60gcaucggcgg cugccuggcc guuggcggcg agcgcacuug cgccugcgca gcgggguccg 120ugccccuccu ccccugggcg gcccccccac ccccccggcg gcgugugaau ggcggccucg 180gcggcagcga cugcagcggc cucggccgcg acggccgccu cggcggccuc ugguagccca 240gggucgggcg agggcucggc gggcggugag aagcguccgg cugcuuccuc agccgcggcg 300gccucugcag ccgcgucguc cccugcgggg ggcgguggcg aggcgcagga gcuucuggag 360cacugcggcg ugugucgcga gcgccugcgg cccgagcggg auccucggcu gcugcccugu 420cuacauucgg ccugcagugc cugccugggc cccgcuacac ccgccgcagc gaauaauucg 480ggggauggcg gcucggcggg cgacggcgcu augguggauu guccagugug caaacagcag 540ugcuacucca aagacaucgu ggagaauuau uuuaugcgug auaguggcag uaaggccucu 600ucugauuccc aggaugcuaa ccagugcugc acuagcugug aagauaaugc cccagccacu 660agcuauugug uggagugcuc ugaaccacuu ugugagaccu guguggaggc ucaccagcgg 720gugaaauaca ccaaggacca cacugugcgc uccacaggac cugcuaagac ucgagaugga

780gagcgaacag ucuacuguaa ugugcacaag caugagcccc ucgugcuguu cugugagagc 840ugugacacac ucaccugccg cgacugccag cucaacgcuc acaaggacca ucaguaccag 900uuuuuggaag augcagugag gaaccaacgu aaacucuugg cuucacuggu gaaacgucuu 960ggggacaaac augccacacu ucagaaaaac accaaggagg uucgaagcuc gauccgccag 1020gugucugaug ugcagaagcg agugcagguu gaugucaaga uggccauucu gcagaucaug 1080aaggagcuga auaagcgggg ucgaguucug gucaaugaug cccagaaggu gaccgagggu 1140cagcaggaac gucuggagcg ccagcacugg accaugacca aaauucagaa gcaccaggaa 1200cacauuuugc guuuugccuc uugggcucug gagagugaua acaauacagc ucucuugcuc 1260ucuaagaagc ugaucuauuu ccagcugcau cgggcccuca aaaugauugu ggauccugug 1320gagccucaug gugagaugaa guuucagugg gaucucaaug ccuggaccaa gagugcugaa 1380gccuuuggca agauuguggc ugagcguccu gguacgaacu ccacaggucc ugggcccaug 1440gcuccuccaa gagccccagg cccucuaagc aagcaagguu cuggcaguag ccagcccaug 1500gaaguacaag agggauaugg cuuuggguca gaugaucccu auucaagugc agagccgcau 1560guaucaggca ugaagcgguc ccgcucuggu gagggagagg uaaguggccu cuuaaggaag 1620gugccacgug ugagccuuga acgccuggau cuggaccuca ccucugacag ccagccacca 1680gucuucaagg ucuuuccugg aagcacuacu gaggacuaca aucugauugu uauugagcgu 1740ggugcugcug cagcagcugc uggucaggcu gggacugugc caccaggagc cccuggugcc 1800ccaccccuuc cuggcauggc cauugucaag gaagaagaga cagaagcugc uauuggagcu 1860cccccggcug cccccgaggg uccugaaacc aagccugugu ugaugccucu gacugaaggu 1920ccuggugccg agggaccucg ucuagcuuca ccuaguggca guaccagcuc aggcuuggag 1980gugguggcuc cugagguuac uucagcccca guaagugggc cagguauccu ggaugacagu 2040gccacuaucu gccgagucug ccagaaacca ggugaccugg ucauguguaa ccagugcgaa 2100uuuugcuucc accuggauug ccaccucccu gcccugcagg auguuccagg ggaggaaugg 2160aguugcucac ucugccacgu gcucccugac cuaaaggagg aagauggaag ccucagccug 2220gauggagcag auagcacugg ugugguagcu aaacucucac cagccaacca gcggaaaugu 2280gagcguguuc uccuggcccu guucugccau gaaccaugcc gucccuugca ucagcuggcu 2340accgacucua cauucuccau ggagcagccu ggugguaccc uagaccugac cuugauucgu 2400gcucgccucc aagagaagcu gucaccuccu uauagcuccc cccaggaguu ugcucaagau 2460gugggccgca uguucaaaca guucaacaag cugacugagg acaaggcaga uguucagucc 2520aucaucggcu ugcagcgcuu cuuugagaca cgcaugaaug augccuuugg ugacaccaag 2580uuuucugcug ugcugguaga accaccacca uugaaccuuc ccagugcugg ccuaaguucu 2640caggagcucu cuggcccugg ugauggcccc ugaagcuggg gcucuugugg ucagcccagu 2700ccagcucugg ucucuguauu uucaccccau acccuguccu uugguggccu gacuccuguu 2760cuugcuggcc ccaucguccc cucagucccu cuucacaaaa ugguuuuuac uucuguggau 2820uuaauaaaaa cuucacugag ucaguuaaaa aaaaaaaa 2858223420RNAHomo sapiens 223uuuuuuuuuu uuuuuuuaaa aauaauuuca uuuuuuaaua uucuguacaa aauuucucaa 60ccuaugaaaa uaaaguuugc aaaagucaaa guaguacaug ggccugcccu ggagccaggc 120ccagccggau cuacacuaug uacaggucuc ccagggugag ccucagcuag ggaaaagcca 180cuaaggugcc uacagagcaa gagggugcca ucgggccagu gcagccucug caauuuccag 240aucugccacu agaggucggc augguccuga uugcuuguca ggcucacccu cuggaagacc 300acagccaaug acaaaggucc ucaagggaaa gcuuuggggu cuagcuggaa gugacggugg 360guccgccgcc caggcgcagg agcaucugcu ggcaguccag caguaaccgg ugaucgccaa 420224963RNAHomo sapiens 224uccgucguaa ccuguugagu aacuauggaa gacuauauca aaauagagaa aauuggagaa 60gguacuuacg guguggugua uaaggguaga cacagaguca cuggccagau aguggccaug 120aagaagauca gacuugaaag cgaggaagaa ggagugccca guacugcaau ucgggaaauc 180ucucuauuaa aagaacuucg acauccaaau auagucagcc ugcaggaugu gcucaugcag 240gacuccaggc uguaucucau cuuugaguuc cuguccaugg accucaagaa guaccuggac 300uccaucccuc cugggcaguu cauggauucu ucacucguua agaguuacuu acaccaaauc 360cuccagggaa uuguguuuug ccacucccgg cgaguucuuc acagagacuu gaaaccucaa 420aaucuauuga uugaugacaa aggaacaauc aaacuggcug auuucggccu ugccagagcg 480uuuggaauac cgauacgagu guacacacac gagguaguga cgcuguggua ccgaucucca 540gaaguguugc ugggcucggc ucguuacucc acuccgguug acaucuggag uauagggacc 600auauuugcag aacuggccac caagaagccg cuuuuccacg gcgacucaga gauugaccag 660cucuucagga ucuucagagc ucugggcacu ccuaacaacg aaguguggcc agaagucgag 720ucccugcagg acuacaagaa caccuuuccc aaguggaagc cggggagccu cgcaucccac 780gucaagaacc uggacgagaa cggcuuggau uugcucucaa aaaugcuagu cuaugauccu 840gccaaacgaa ucucuggcaa aauggcccug aagcacccgu acuuugauga cuuggacaau 900cagauuaaga agauguagcc cucuggaugg augucccugu cugcuggucg uaggggaaga 960ucg 963225479RNAHomo sapiens 225uuuuuuuuuu uuuuuuuacu aggcaaagaa uuuuauuaac ccuuuccaaa cuuuauuccc 60aggcuucuuc agcuuuauuu gccgcaaaga augaauuagg uauagcgaaa acugaaaaga 120gcugcagugu ccgggggcuu gggcuuaaaa auauuagaga ucuagauuuu aucagaucca 180uaauaaacaa aaaaauuuua aaaagcaguc augauauaaa auagcagcuc cuguaauuuc 240ugcaaguauc accuucuuca gaaguugcuu caauucaguu ugccucauuc uuagaagccu 300caucaaaauu cuccaccaga ucuggaacuu caucaucauc auccucucca guagcaaggg 360gugcuuuucc auccacagau uguuugggca gagcuucagc cagucuccuu aaacuaguca 420ggcugucugc accaagcugg uugaggaugc ugggaagcau uucugucagc ugcuuuguc 479226520RNAHomo sapiens 226uuuuuuuuuu uuuuuuuauu caugcuugcc uagggauggg gaauagauca uucaauaaaa 60acauacagua aaaacagggg guggggaggg ggaaggcuua ucauguacaa uguuuaaacu 120acaauaguga uguaccuuaa uuacuuccau gcacacaagu cuaacauuac aaguuuuuaa 180aaaauaaaca ccauuaagac uucuaggagc auuuuauaau aaauuccuaa uuuuuucuuu 240guagauagau caagcaccuc caaaauacag auuccuauac acagugagca cuuuacuuaa 300cguacaugga cagccucagg acgagcugac gucucggauc agcucggcag gcaacaaacc 360auagugccaa auggaaagaa gggcaguugc aaauaaacuu aaaacuaagu uaacuuuuau 420aauuaaauac agaaaauaua cugauuugcu aaaaauaaau aagaugugau guauuuaaca 480cuucacuaua aagaaugaac accaugacau ccucgugccg 520227468RNAHomo sapiens 227agaagaagga ggagugggac cgcaagcaug aggaugcuag uagggaguau gagaaaggca 60ugaaagagua ugaaggagga agaggggacu caucuaaaag ggacaagucu aagaagaaaa 120agaaaguaaa agcaaagaug gaaaaaaagu ccacuccuuc ccggggcucg ucauccaagu 180cuucauccag gcaguugagu gacagcuuca agagcaaaga guuugugucc agugaugaga 240gcucuucagg cgagaacaag agcaaaaaga agaggaggcg gacgaggacu cugaagagga 300gcuagccagu accccuccaa gcucagagga cucugccucg ggaucugaug aauaaaggag 360ggaauuccca ccccgucaca gcuccagucu cucacauagu ccuuggauuc ugugccaucu 420gaguaacugc ucuugguggc uuccacugcc cugaggcuuu gagggaag 4682281740RNAHomo sapiens 228aucgucguaa ucguuugcag acuucucgcc gucgccuugu aagcuuuguc uucgccuugc 60aagcuuuguc uucaggguug gaaagaugag acauucaaag agaacuuacu guccugacug 120ggaugaaaga gacugggauu auggaacaug gagaagcagc agcagucaca aaagaaagaa 180gagaucacau agcagcgccc gugagcaaaa gcgcugcagg uacgaucacu ccaaaacgac 240agacagcuau uaucuggaaa gcagauccau aaaugagaaa gcuuaucaua gucgacgcua 300uguugaugaa uacaggaaug acuacauggg cuacgagcca gggcaucccu auggagaacc 360uggaagcaga uaccagaugc auaguagcaa guccucuggu aggaguggaa gaagcaguua 420caaaaguaaa cacaggaguc gccaccacac aucgcagcac cauucacacg ggaagaguca 480ccgaaggaaa agaucgagga guguagagga ugaugaggag ggucaccuga ucugucagag 540uggagacgua cuaagugcaa gauaugaaau uguugauacu uuaggugaag gugcuuucgg 600aaaaguggug gaaugcaucg aucauaaagu gggagguaga cguguagcag uaaaaauagu 660uaaaaaugug gauagauacu gugaagcugc ucaaucggaa auacaaguuu uggaacacuu 720gaauacaaca gacccccaua guacuuuccg uuguguccag auguuggagu gguuugagca 780ucgaggucac auuugcauug uguuugaacu ucuggggcuu aguacuuaug auuucauuaa 840ggaaaacagu uuucugccgu uucgaaugga ucauaucagg aagauggcau aucaaauaug 900caaaucugua aacuuuuugc auaguaauaa auugacucau acagacuuga agccugaaaa 960caucuuauuu gugaagucug acuacacaga ggcuuauaau cccaaaauga aacgugauga 1020acguacuaua guaaauccag auauuaaagu gguggacuuu ggaagugcaa cauaugauga 1080ugaacaccac agcacauugg uaucuacaag acauuauaga gcaccggaag uuauuuuagc 1140ccucgggugg ucacagccau gugaugucug gagcauagga uguauucuua ucgaguauua 1200ucuuggauuu acaguuuuuu cgacucauga uagcagggaa cauuuagcaa ugauggaaag 1260gauucuugga ccacuaccaa agcacaugau acagaaaacc aggaaacgca gauauuucca 1320ucaugaucga uuagauuggg augaacacag uucugcuggc agauauguuu cucggcgcug 1380uaaaccucug aaggaguuua ugcuaucuca ggaugccgaa caugagcuuc ucuuugaccu 1440cauugggaaa auguuggagu augaucccgc caaaagaauu acucucaaag aagcccuaaa 1500gcauccuuuc uuuuacccac uuaaaaagca uacgugauuu auaaacacag ugcucugaaa 1560ggaaucuuac agacuguauc agucuagcuu uuaauuaagu uauuuuguau agcuuaauuu 1620guaaaacauu uuauguuuuu uagaugcuuu auuaaauaca uggccaaacc aaauaacauc 1680uuucaguaau uauagaauga uuuauuugga auaaaauuug ugcuuaugaa uguaaaaaaa 1740229815RNAHomo sapiens 229ggacucgcga caagcguccu cagcgcgaag aggcggacuc ggaguccucg ccuugagccu 60ugcaucugag aaguuccagg uacuuuguac aacugcaucc cagaaccugu guguuuucag 120caccuuuaua agugauggcu gccaucagga agaaacuggu gauuguuggu gauggagcuu 180gugguaagac augcuugcuc auagucuuca gcaaggacca guucccagag gucuaugugc 240ccacgguguu ugaaaacuau guggcggaua ucgaggugga ugggaagcag guagaguugg 300cuuuauggga cacagcugga caggaagauu augacugccu gaggccucuc ucuuauccag 360acaccgaugu uauauugaug uguuuuucca uugacagccc ugauaguuua gaaaacaucc 420cagaaaaaug gacuccagaa gucaagcauu ucuguccaaa ugugcccauc auccugguug 480ggaacaagaa ggaccuucgg aaugacgagc acacgagacg ggaguuggcc aaaaugaagc 540aggagccggu aaaaccugaa gaaggcagag auauggcaaa caggauuggc gcuuuugggu 600acauggagug uucagcaaag accaaagaug gagugagaga gguuuuugag auggccacga 660gagcugcucu gcaagcuaga cgugggaaga aaaagucugg gugccucauc uugugaagcc 720uugugaacgc agccucaugc gguuaauuug aagugcuguu uauuaaucuu aguguaugau 780uacuggccuu ucauuuaucu auaauuuacc uaaga 815230287RNAHomo sapiens 230uucaagaccg accugcgcuu ccagagcucg gccgucaugg cucugcagga ggcgagcgag 60gccuaccucg ugggucuguu ugaggacacc aaccugugcg ccauccacgc caagcguguc 120accaucaugc ccaaggacau ccagcuggcc cgucgcauuc guggggagag ggcguaaauu 180aggguaguga gugaauuugg accccaaagg cucuuuucag agccacccac auuuucuaua 240aaaggcugua uaucgauaag cuuuuauaaa ccccacucag caacucc 287231945RNAHomo sapiens 231uuaugugaua aaaaaauuca acuugguauu aacuuaacua agggccuugg ugcuggugcu 60uugccugaug uugguaaagg ugcagcagaa gaaucaauug augaaauuau ggagcauaua 120aaagauagcc auaugcucuu uaucacagca gggaugggug gugguacugg aacaggugcu 180gcaccgguaa uugcaaaagc agccagagaa gcaagagcgg uaguuaaaga uaaaggagca 240aaagaaaaaa agauacugac uguuggaguu guaacuaagc cguucgguuu ugaaggugug 300cgacguaugc gcauugcaga gcuuggacuu gaagaguugc aaaaauacgu agauacacuu 360auugucauuc ccaaucaaaa uuuauuuaga auugcuaacg agaaaacuac auuugcugac 420gcauuucaac ucgccgauaa uguucugcau auuggcauaa gaggaguaac ugauuugaug 480aucaugccag gacugauuaa ucuugauuuu gcugauauag aaacaguaau gagugagaug 540gguaaggcaa ugauugguac uggagaagca gaaggagaag auagggcaau uagugcugca 600gaggcugcga uaucuaaucc auugcuugac aauguaucaa ugaaaggugc gcaaggaaua 660uugauuaaua uuacuggugg uggagacaug acucuauuug aaguugauuc ugcagccaau 720agagugcgug aagaagugga ugaaaaugca aauauaauau uuggugccac uuuugaucag 780gcgauggagg gaagaguuag aguuucuguu cuugcaacug gcauugauag cuguaacgac 840aauucaucug uuaaucaaaa caagauccca gcagaggaaa aaaauuuuaa auggccuuau 900aaucaaauuc caacauuaga aacaaaagaa uaugcuucaa cugag 945232238RNAHomo sapiens 232ugaucagguc acauuccggu gccuuccacc cccuauggca cgggcgcccc gccuugccau 60accacagcuc ccuccaggcu uagaccuggc uucaccgcau uucaggugcu auaccccccc 120cugcuuuucc ccccauugcc cuuaaaugcc ccucggcccc uccauccccc cggaacaggg 180uggcacuugc cacucucagg accaccuugc caaggagaau aaaccgaauc cuguugcu 238233341RNAHomo sapiens 233uuuuuuuuuu uuuuuuucac ucaucacguu uauucagaag agaauacacc caauccucuc 60aucucuggaa aguuuuguuc cuagccauca uuaagaucag gaccccuguu cuccccuuaa 120ccccaggaga ggaagcuuau agucuuugua gauauucuga accucugauc acaaaggguu 180auaaaauagu gaagggguuu ggacuaggaa aggcacagac ugaaaggaau cugccagggg 240acugaggcca cagcuccccc aggagucaga ggaaggggga agucacguau uuuauagaag 300gccaagggcc ucagagcaag aguauuccuu ugaagagcuc a 341234495RNAHomo sapiens 234ugguggagca ggucucagga aucucuucgc uucagcuuca aucauggccu guggucuggu 60cgccagcaac cugaaucuca aaccugggga augucucaaa guucggggag agguggccuc 120ggacgccaag agcuuugugc ugaaccuggg aaaagacagc aacaaccugu gccuacacuu 180caauccucgc uucaaugccc auggagacgc caacaccauu guguguaaca ccaaggaaga 240ugggaccugg ggaaccgaac accgggaacc ugccuucccc uuccagcccg ggagcaucac 300agaggugugc aucaccuuug accaggcuga ccugaccauc aagcugccag acggacauga 360auucaaguuc cccaaccgcc ucaacaugga ggccaucaac uacauggcgg cggauggaga 420cuucaagauu aagugcgugg ccuuugagug aagccagcca gccuguagcc cucaauaaag 480gcagcugccu cugcu 495235861RNAHomo sapiens 235gugguucuuc ggcgccaggu ucgcccgcuu cugcccuuag guaacauucu cuaaacugcg 60uuucucuccc aaucuuuugc aggcauuugg ggacuuuuuc uuuucuuuuu acuuucucuu 120uuucuuuugc acaagaagaa gucuacaaga ucuuuuaaga cuuuuguuau cagccauuuc 180accaggagaa cacguugaau ggaccuuuuu aaaaagaaag cggaaggaaa acuaaggaug 240aucgucuugc ccaggugucu uguucuccgg ccuggacugu gauaccguua uuuaugagag 300acuuucagug cccuuucuac aguuggaagg uuuucuuuau auacuauucc caccaugggg 360agcgaaaagg uuaaaaaaaa gaaaaaaauc acaaggaauu gcccaaugua agcagacuuu 420gccuuuucac aaagguggag cgugaauucc aggaggaccc aguauucggu uacuuaaaug 480aagucuucgg ucagaaaugg ccuuuuugac acgagccuac ugaaugcugu guauauauuu 540auauauaaau auauauauau ugagugaacc uuguggacuc uuuaauuaga guuuucuugu 600auaguggcag aaauaaccua uuucugcauu aaaauguaau gacguacuua ugcuaaacuu 660uuuauaaaag uuuaguugua aacuuaaccc uuuuauacaa aauaaaucaa guguguuuau 720ugaauguuga uugcuugcuu uauuucagac aaccagugcu uugauuuuuu uuuaugcuau 780guuauaacug aacccaaaua aauaccaguu caaauuuaug uagacuguau uaagauuaua 840auaaaaugug ucugacauca a 861236830RNAHomo sapiens 236cgaugaaggc ggugagcccg gugcgccccu cgggccgcaa ggcgccgucg ggcugcggcg 60gcggggagcu ggcgcuacgc ugccuggcgg agcacggcca cagccugggu ggcucggcag 120ccgccgccgc cgcugcggcg gccgcgcgcu gcaaggcggc cgaggcggcg gccgaugagc 180cggcgcugug ccugcagugc gauaugaacg acugcuacag ucgccugcgg aggcucgugc 240cuaccauccc gcccaacaag aaagucagca aaguggagau ccugcagcac guuaucgacu 300acauccugga ccugcagcug gcgcuggaga cucacccugc uuugcugaga cagccgccac 360cgcccgcgcc accucuccac ccggccgggg cuuguccggu cgcgccgccg cggaccccac 420ucaccgcgcu caacacugac ccggugagaa gccuuggcgg gcacccuggg caucgcggga 480aagguggcgg ggcggcgaga uacggguggu cuugcuccuc ucagggaaug acagccgcuu 540cucccgucuc caccgagagc cgccugcugg gcuuggugau ccacuggucc cugagccgag 600ggcgguuggg cuuggagccc ugcgucuccg gagugucccu ugcaucacag gaggcuuccc 660cagcuucggg cucggguggg gacucugcuc accugccuag uuuuccagga cgucuccugg 720gugguggcga cacugugaua ugcgcacucu aaccgcuuuu ccccuuggug uuggguugcu 780guuccaggcc ggcgccguga acaagcaggg ugacagcauu cucugccgcu 8302375560RNAHomo sapiens 237acuagucucg accauguacc aucacggaga cgacaccaac agugacauga acagugacga 60cgacaugagc cgaaguggga gagaaacccc acccccucga ccaucucaug cuuuuggcag 120ugagcgagac cuggagcgca ggggcagaag cagagaugug gagccucgag accgcuggcc 180auacaccagg aaucccagaa gcaggcugcc ucaacgggau cuuucucuuc cugugauguc 240aagaccacau uuuggacugg acagagauga ugacagacgu uccauggauu augagucucg 300aucccaggau gccgagucau accagaaugu uguggaacuc aaagaggaca agaagccuca 360gaauccaauu caggacaacc uggagaacua cagaaagcug cucucgcugg gaguccagcu 420ugccgaagau gaccgacacu cucacaugac acaaggccac ucaucgaggu ccaagagagc 480ugccuaccca agcaccagcc gaggucucaa acccaugccu gaggccaaaa agccauccca 540caggcguggg aucugugagg acgagucuuc ucauggagug auaauggaaa aauucaucaa 600ggauguggcu cgcaacccca aauccggaag agcaagggag cugaacgagc guccuccucc 660aagguucccc aggccuaaug auaacuggaa ggacaguucc uccagcagaa gagagucagu 720gauccaggag agggguuaug aagggagcgc auuuaggggc ggcuuccggu ucaacgcaga 780ccuggcuucc agaagcagag cucuagaaag gaagaggcgu uaccacuuug auucugauga 840gcgggguucg ggccaugagc auaaaagcug ugugaggaag aagccuuuug aguguggugc 900ugagaugaga caggcuauga gcaugggcaa ccugaacagc ccuuccuucu cugagucgca 960gucaaucgau uuuggggcca acccauacgu gugugaugag ugcgggaggc aguucagugu 1020caucucugag uuuguugagc accagaucau gcacacuagg gagaaccucu augaauaugg 1080agaguccuuu auucauagcg uggcugucaa ugaggugcaa agaagucagg guggggggaa 1140acgcuuugag uguaaggaau guggagaaac cuucaguagg agugcugccc uggcagagca 1200ccgccaaauc caugcuagag aauaucuugc agaauguaga gaucaggagg augaggagac 1260caucaugccu agcccgaccu uuagugagcu gcagaagaug uauggcaaag auaaguucua 1320ugagugcaag gugugcaagg agaccuuucu gcacaguucc gcccugauug agcaccagaa 1380aauccauggu agaggcaacu cagaugacag agauaaugag cgugaacgcg aacgugaucg 1440ucuacgugca cgugcacgag agcagcguga gcgcgaacgu gaacgggagc gugagcguga 1500gcuuggggaa cccuuucuga ccuguccaaa cuucaaugag uuucggaaga uguacaggaa 1560agacaaaauc uaugagugca aagugugugg ggagagcuuu cuucaucucu caucccugag 1620ggagcaucag aaaauccaua cuagaggaaa cccauuugaa aauaagagca ggaugugcga 1680ggagaccuuu gucccuaguc agucucuccg acggcgccag aaaacuuaca gagagaagcu 1740guucgacuuu aacaaugcca gggaugcacu gaugggaaac ucagacucca gcgagcauca 1800gaaaaaccgu ucccgaagga acuucuuuga gggcagagga uuugagaaac ccuucguuga 1860aucucagaag agucauacua uaacaagacc accugaaaac aaagacgaug acaagccguu 1920cacaaucagu gucaacccua augacaagcu gaaacucccc aucauggaaa auggcuccca 1980gggcaaaucc ugugagaggu cuguuauuca uagcuugggc uccgcagaag cucagaagag 2040ucauggugga cugggguuca guaaaccaag accaguggca gagucuagca cccagagcuc 2100aagcagcauu uacuacccca gagcacacuc uggaggcaac accuaugaag gaaaagaaua 2160caaggacucu aucauccaua gcuugccagc uccucgaccu cugaaacguc auagagcaaa 2220ugaccauauu caaugugaug aggggggaga auccuccauu uauaucccag auauuauuaa 2280uaagggaagg aagauuccug ccagagaaga ugcuuaugaa ggaaguagca gcagcaacua 2340ccacacacca aauguauccc gugcugagcc uccaagucuu ucuggagagu cccaugacuc 2400uaagcaggau gucacguuuu caguucccag cucaaguguu cgugaacacc agaaagcucg 2460ugccaaaaag aaguacauug agcccaggaa caacgagacc ucuguuaucc acucccuacc 2520uuuuggugag uugcuugcag gucaccguag ggcaaaguuc uuugaguguc aggaaugcgg 2580ggaggccuuu gcucguaggu cugagcucau ugagcaccag aagauucaug auagagaaag 2640accuucugga agccgacauu augagcgcuc ugucauccgc agccuugcgc ccagugaccc 2700ucagaccagu uaugcccaag aacguuucau ccaagaacaa gugcguaaau ucagagcguu 2760uggacaacgc ucaacuacca gcaacaaccu caguguacag aaaaucuaug cccaagagac 2820auuuaaugcc gaggagcccc augauaaaga aacucauggu caaaaaauuc augacaaaga 2880gccauauggu aaggagccca guggcaagga gccccauggu

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ccaaguucga gucccugggu cuacauggua ggagagagcu 3000ggcuucugca aguuguccuc ugaccaccac acauaaauaa auaacaaaug uaauuuacaa 3060acuuuuaaaa gaaaauguaa uuuaaaaaac cagacguucu agacuguucu gggcuuggga 3120aauauuuuuu ucacuuuccu aagguguacu uuccuuugcu acauuaauua uugcagccuu 3180guucgaugau cuaagugggg auauuugaca auggcagauu uauucauugc aacaaggaaa 3240gacacagcca uugaugaaaa aaaaaagaaa gucucagcuu ucagugacug ggauaccugc 3300uguccaggga ggaggcucag uuagacuacc cucugcuuac uugaggucug acaugcccaa 3360ugagagugua uuuagcuuua uuuaaaguuc uuaaugccaa caguuuuaaa aaucacauuu 3420aaaugaacug uacaagguag ccagaccuug aauguaugaa uagacuauau aauauguccc 3480gagaaacuuu guuacucuca gcucuguuga uugcgaaauc uugcauagau uaugcuuuga 3540uuuaguuucu 35502502299RNAHomo sapiens 250ccugggcccc gccgcggacg cgcggagccg ccugggccgc gccggaggag ggcggggaga 60ggaccaugug aaugugcucc ggagcugagc gccaagccaa gcaguguuug aaaggaacag 120gaugcugauc uaaucguggc aaaaagucag uccgaccgcu gguuucgaag acauguggug 180uauauaaagu uugugauagu ugguggaaau uugggagcuu ggauaauggg cugugugcaa 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aggccgguga ugaaggaaau gcuggcccag 1380acggugcccc uggagagagg gguggcccug gugaaagagg accucggggg accccuggug 1440ugagaggacc aaggggagac ccgggugaag cuggaccaca gggugaccaa ggaagagagg 1500ggcccgucgg caucccugga gacucgggug aggcuggccc cauuggaccu aaaggauacc 1560gaggugauga ggguccucca gguccugagg gccucagagg agccccagga ccuguugguc 1620cuccuggaga ccccggacug augggugaga gaggugagga uggaccacca ggaaacggca 1680cggaagguuu ccccggcuuc ccuggguauc caggcaacag aggcccuccu gggcuaaaug 1740gcacaaaagg cuacccuggc cucaaggggg augaggguga agugggagac ccaggagagg 1800auaacaacga cauuucaccc cgugggguca aaggggcaaa gggauaccga ggcccagaag 1860gaccccaggg accuccagga caugugggac caccugggcc agaugagugu gagauccugg 1920auaucaucau gaaaaugugc uccugcugug agugcacaug uggacccauu gacauccucu 1980ucgugcugga cagcucggag agcauuggcc uacagaacuu ugagauugcc aaggacuuca 2040ucaucaaggu cauugaccgg uugagcaagg augagcuggu caaauuugag ccagggcagu 2100cucacgcggg cgugguacag uacagccaca accagaugca agagcacgug gacaugcgga 2160gccccaacgu ccgcaacgcc caggacuuca aagaagcugu caagaagcua caauggaugg 2220cugguggcac auucaccgga gaagcgcugc aguacacccg ggaccggcua cucccaccca 2280cacagaacaa ccgaauugcc cuggucauua cggauggacg uucugacacu caacgggaca 2340cgacaccucu cagugugcuc uguggugcag acauucaggu aguuucugug ggaaucaagg 2400auguguuugg cuuuguggcg ggcuccgacc agcucaaugu cauuuccugc caaggcuuau 2460cgcaaggucg uccagguauc ucccugguga aggagaacua ugcagagcuu cucgaugacg 2520gcuuucugaa gaacauaaca gcccagaucu guauagauaa gaaguguccg gauuauaccu 2580guccaaucac auucuccucc ccggcugaca ucaccauccu gcuagacagc ucagccagug 2640ucggcagcca caacuucgaa accaccaagg ucuucgccaa gcgccuagcu gagcgauucc 2700ugucagcagg cagggcggau ccuucccagg augugcgggu ggccguggua caguauagug 2760gccaggggca gcaacagcca ggucgggcgg cucuucaguu cuuacagaau uacacagugc 2820uggccagcuc uguggacagc auggauuuca ucaacgacgc cacagacguc aacgaugcuc 2880ugagcuacgu gacucguuuc uaccgggaag ccucgucagg ugccaccaag aagagagugc 2940uguuguuuuc agacggcaac ucucaggggg ccacagcaga ggccauugag aaggcugugc 3000aggaggccca gcgugcaggc auugagaucu uugugguggu ggugggaccc caggugaacg 3060agccccacau ccgugugcuu gucacuggca agacugcaga guacgacgug gccuuuggcg 3120agcgccaccu auuccgugua ccaaacuacc aggcccugcu acguggcgua cucuaccaga 3180cagucuccag gaagguggca cugggcuaga gggccacaca cguggcugga cacacauggc 3240auggagacac auuucaacag gccuucccgc ccuucccacu gacaaaacag gaauaggaaa 3300ugugacccaa cuggucaacu caacugucuu aaagggaacg cugagaugca cacucuuugc 3360uuuguguaau guccccugug gcucaccuga gcuccuaucu agaucccgcc cuugguuugu 3420acaucauggu ggccaucuug cugaccccuc ccccaucugg gacuggaucc agccaucucg 3480ucuuccuccu cacugccccu aaccuauccg uggugucuuc acaccaucac ugcaguuucc 3540gucuguguuc ugucuuccau gcucaacaug aagcagaccu ucucaugagu ucagcuugcu 3600ggauuauggc uuuuaggaaa uugaacacag gaggaguucc aaacacaaac uuggaggaga 3660ccccuccucu ucaucaggug cuugucagug accuacaugc aucuuggucu gguccuuagu 3720ggcuaguccu uccacucuga aagcaaaggu gcuaucuauc uguaagggcu cucucuacac 3780acccagaggc uuagcuugga caguucacac ucaagugucc ugucagaauc aauccagagc 3840uuucucccuc aaaauaguga cuugucuccc ccuggucccc aaaggcuccc cuuuaguuag 3900uuucuucaug gcucccccac auuccccgua aucugaucca agccagcuau cucugcuaau 3960aaagguuucc auuuuucaaa aaaaaaaaaa a 3991252235RNAHomo sapiens 252accccaugcc ccacccccac cuucgauguu uugaacauuu cuaacaacug aagccaguaa 60agucauauuc uuuaaauuuc caggacauuc auauuauuca cauaaucaug gucaugguga 120ugauggaaac ugaggacuuu aaaagagauu uucccuuccc aaacguuucu ggacaguacc 180ugauuguauu uuuuuuguuu uguuuuguuu uuuaauaaaa gcacaguacu uuucc 2352532005RNAHomo sapiens 253gucugcccug ccguuucucu acuucccagc cuucucaucu ccaggaacca ugucuaccaa 60aaccaccauc aaaagucaaa ccagccaccg uggcuacagu gccagcucag ccagagugcu 120uggacucaac cgcucgggcu ucagcagugu guccgugugc cgcucccggg gcagcggugg 180cuccagugca auguguggag gagcuggcuu uggcagcagg agccucuaug guguggggag 240cuccaagagg aucuccaucg gagggggcag cuguggcauu ggaggaggcu auggcagccg 300auucggagga agcuucggca uugguggugg agcugguagu ggcuuuggcu ucgguggugg 360agcuggcuuu ggugguggcu augggggagc uggcuucccg gugugcccac uuggaggcau 420ccaagagguc accaucaacc agagccuccu cacaccccug aaccugcaaa uugaccccac 480cauccagcgg gucaggacug aggagaggga gcagaucaag acccucaaua acaaguuugc 540cuccuucauc gacaaggugc gguucaugga gcagcagaac aaggucaugg acaccaagug 600ggcccugcug caagagcagg acaccaagac cgugaggcag aacauggagc ccauguuuga 660gcaguacauc agcaaccucc gcagacagcu ggacagcauc auuggagaga ggggucgcau 720gaacucagag cugaggaaca ugcaggaacu cguagaagaa cuacggaaca aauaugaaga 780ugaaaucaac aagcgcacag acgcagagaa ugaauucgug acccugaaga aggauguaga 840ugcugccuac augaacaaag uugaacugca agccaaggca gacagucuaa cagaugauau 900caacuucuug agagcucucu augaagcaga acugucucag augcaaacuc acaucucaga 960cacaucugug guccucucca uggucaacaa ccguagccuc guccuagaca gcaucaucgc 1020ugaggucaag gcccaguuug aggucauagc ucagagaagu cgggcugaag cugagucauu 1080guaccagacu aaauaugagg agcugcaggu cacagcuggc agacaugggg acgaccugcg 1140caacaccaag caggagauug cugagaucaa ccgcaugauc cagaggcuga gaucugagau 1200cgaccacguu aagaagcagu gugccaaccu gcaagcugcu auugcugaug cugagcaacg 1260uggggagaug gcccugaagg augcaagggg caagcuggaa gggcuggagg augcccugca 1320gaaggccaaa caggacaugg ccaugcugcu gaaggaguac caugaacuca ugaaugucaa 1380gcuggcccuu gauguggaaa uugccaccua caggaagcug cuggaaggag aggagugcag 1440guugaauggu gaagguguug gaccagucaa caucucugug gugcagucca ccguguccag 1500cggcuauggc agugccgggg gugccagcag cagcuuaggc auggguggag gcagcagcua 1560cuccuauagc agcagccaug gccuuggagg uggcuucagu gcuggcagug gcagagccau 1620cggagguggc cucagcucuu cugguggccu cagcucuucu accaucaaau acaccaccac 1680cuccuccagc aagaagagcu acaggcagug aauucuguca ccaagagcuu gucucugguc 1740ccagauguca uggcugcagc ugaaccacau gcuuugguuc ccggaaggga acgaauccca 1800accucuggcc uccccauggc ucaguucuac auuuguguug cacgucagca ccuauacaug 1860uucuuuggug acccagaccc caaaauguug cagaauguag accuccaaga cgaaacccca 1920aacccuaccc agaauaccca ccuaaauucu gucaugguuc ugacuuccuc cagagucugu 1980aaaauaaaau gcccccacaa caaac 2005254357RNAHomo sapiens 254uuuuuuuuuu uuuuuuugau uuuaauuaca aacuuuauuu guccuccagu ucacaguuua 60uacgugguac aucccaccau gucagcuucc agaacggcua uucaggagau ggguggagcu 120uucuuuguaa aggaacccga cauuuuaaaa uuuugguuag aaucuucaua gguuuauaaa 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960gguccugccg guccaguggu ccagagcccc aacucacaac cugucccugg agcacaagga 1020cccccgggac cucaggggcc accagggaag gauggcacuc caggaaggga uggugaaccg 1080ggugacccug gugaagaugg gagaccgggu gacacuggac cucaaggcuu uccagggacc 1140ccaggagaug ugggcccuaa gggcgagaag ggagauccug guauugggcc ccgaggaccu 1200ccagggccuc cagggccacc aggacccucc uucagacaag acaagcugac cuucauugac 1260auggagggau ccgguuucag cggagacaua gagagccuua gaggcccacg aggcuucccu 1320ggccccccgg ggcccccugg ugucccagga cuuccuggug agccaggacg cuuugggauc 1380aaugguuccu augcaccagg accugcaggc cuuccuggug uaccugggaa ggaaggaccc 1440cccgguuuuc cagguccccc gggaccucca gguccuccag gcaaagaggg cccaccagga 1500guggccggcc agaaaggcag uguuggugau gugggcaucc caggacccaa ggggagcaaa 1560ggagaccuug ggcccaucgg uaugccuggc aagucuggcu uggcuggauc cccugggcca 1620guuggacccc caggaccucc agggccucca gggccaccag gaccaggauu ugcugcugga 1680uucgaugaua uggaaggcuc uggaauaccc cucuggacaa cagcccgaag cucugauggg 1740cugcagggac cucccggguc gccgggacuc aagggggauc cuggaguggc aggccuaccu 1800ggagccaagg gagaaguugg agcagaugga gcccagggca ucccuggucc cccaggaaga 1860gaaggugcag cuggaucucc ggggccaaaa ggagagaagg ggaugccggg agaaaaggga 1920aacccaggaa aagauggagu gggccggccg ggccucccug ggccuccagg accuccaggg 1980cuggugaucu augugucaag ugaggauaaa gcaauaguga gcacgccagg accugagggc 2040aagccagggu acgcaggcuu uccuggaccu gcuggaccga agggugaccu ggguuccaaa 2100ggcgagcagg gucuuccggg guuuaagggu gagaagggag agccaggcac uaucuuuagu 2160ccugauggca gacgucuggg ccauccccag aagggagcca agggagagcc aggcuuucga 2220ggacccccgg guccuuaugg acgaccuggg cacaagggug aaauuggcuu cccuggacgg 2280ccgggucgac cuggaacgaa uggcuuaaag ggagagaagg gagagccugg agaugccagc 2340cuuggguuca gcaugagggg auugccuggc cccccugggc cuccaggacc cccagguccu 2400ccugggaugc ccaucuauga cagcaaugca uuuguggagu cuggccgacc uggacuacca 2460ggacagcagg gugugcaggg gccuucagga ccaaagggug acaaaggaga gguggggcca 2520ccugggccac cagggcaauu ccccauugac cucuuccacc uggaagcgga aaugaagggg 2580gacaagggag accgagggga ugcuggacag aaaggagaga ggggagaacc uggggcuccu 2640ggugguggau ucuucagcuc aaguguaccu ggcccacccg gcccaccugg auacccugga 2700auuccggguc caaagggaga gagcauccgg gggccaccug gcccuccugg cccgcaggga 2760ccuccuggca uuggcuauga gggucgccag ggucccccag gaccuccagg accuccagga 2820ccucccuccu ucccuggccc ucacagacag acugucagug uuccuggucc uccgggccca 2880ccugguccuc cagguccccc aggagccaug ggugccucug cugggcaggu gaggaucugg 2940gccacauacc agaccaugcu ggacaagauc cgggaggugc cggagggcug gcucaucuuu 3000guggccgaga gggaagagcu cuauguacgc guuagaaaug gcuuccggaa ggugcugcug 3060gaggcccgga cagcccuccu gagaggcacg ggcaaugagg uggcugcuuu ccagccccca 3120uugguccagc uucaugaggg caguccauac acccggaggg aguacuccua uuccacggca 3180cgacccuggc gagcagauga cauccuggcc aacccaccgc gccugccaga ccgccagccu 3240uacccuggag uuccacauca ccacaguucc uaugugcacc ugccgccagc ccgccccacc 3300cucucacuug cucauacuca ucaggacuuu cagccagugc uccaccuggu ggcacugaac 3360accccccugu cuggaggcau gcgugguauc cguggagcag auuuccagug cuuccagcaa 3420gcccgagccg uggggcuguc gggcaccuuc cgggcuuucc uguccucuag gcugcaggau 3480cucuauagca ucgugcgccg ugcugaccgg gggucugugc ccaucgucaa ccugaaggac 3540gaggugcuau cucccagcug ggacucccug uuuucuggcu cccaggguca agugcaaccc 3600ggggcccgca ucuuuucuuu ugacggcaga gauguccuga gacacccagc cuggccgcag 3660aagagcguau ggcacggcuc ggaccccagu gggcggaggc ugauggagag uuacugugag 3720acauggcgaa cugaaacuac uggggcuaca ggucaggccu ccucccugcu gucaggcagg 3780cuccuggaac agaaagcugc gagcugccac aacagcuaca ucguccugug cauugagaau 3840agcuucauga ccucuuucuc caaauaggcc ucugccagcu aggguggcag acagaggcca 3900ugcagaacuu ugacacagcg cagggagcau ucagucagca cccagggcuc uggcugggau 3960acaacuccug uauaguuccc auuuuuaugu aauccucaag aaauaaaagg aagccaaaga 4020guaaaaaaaa a 40312581503RNAHomo sapiens 258aacugccuuc gagaagcguu agccuagaga uccgagccuc uucuccauac cauaguuggu 60ucaggugguu uccucuucaa accuugcguc ugcggauaau ccgcgcggcc gggcguuaag 120cuccaggucc cugucgcucc gucgaggugg caagccaugg ccggcugcug cuguuugucu 180gcggaggaga aagagucuca gcgcaucagc gcggagaucg agcggcacgu ucgccgcgac 240aagaaggacg cgcgccggga gcucaagcug cuguugcugg gaaccgguga gagugggaaa 300agcaccuuua ucaagcagau gaggauaauc caugggucug gcuacaguga ugaagauaga 360aagggcuuca cgaagcuggu uuaccaaaac auauucacgg ccaugcaagc caugaucaga 420gcaauggaua cccugaggau acaauacaug ugugagcaga auaaggaaaa ugcccagauc 480aucagggaag uggaaguaga caaggucacu gcacucucua gagaccaggu ggcagccauc

540aagcagcugu ggcuggaucc cggaauccag gaguguuacg acaggaggag ggaguaccag 600cugucagacu cugccaaaua uuaccugacg gacauugagc guaucgccau gcccucuuuc 660gugccaacac aacaggaugu gcuucguguu agagugccca ccacuggcau cauagaauau 720ccauucgacc uggaaaacau caucuuccga augguggaug uugguggcca gcgaucugaa 780cgacggaaau ggauucacug cuuugagagu gucaccucca ucauuuucuu gguugcucug 840agugaauaug accagguucu ggcugagugu gacaaugaga accgcaugga ggagagcaaa 900gcccuguuua gaaccaucau caccuacccc ugguuucuga acuccuccgu gauucuguuc 960uuaaacaaga aggaucuucu agaggagaaa aucauguacu cucaucuaau uagcuacuuc 1020ccagaguaca caggaccaaa gcaagauguc aaagcggcca gggacuuuau ccugaagcug 1080uaucaagacc agaauccuga caaagagaag guuaucuauu cucacuucac uugugcuaca 1140gacaccgaga auauccgcuu uguguuugcu gcugucaaag acacaauccu acagcuaaac 1200cuacgggagu ucaacuuggu guaaauggag ggccuacucc uccgagacag agggugaucu 1260gagcccuucc ugccugaucu acaagugcuu cuggaccagg accuaaggac auuauguagc 1320ccacaggaca gagaugggua gugcaaugug aaaaauacuu caccaacccu uuuaaguguc 1380uuuaauucuu cacugucuaa cucuuuucuc gccuuuuggu ugaacgauua gguaucauuu 1440uugagugguu cccccucucc uauuuuuuua aacuaguguu caacaguuau uaaaaaauca 1500ugc 1503259876RNAHomo sapiens 259gaauucccug caaccuuguc ugagaggaag caaggacugg ugugaggagg gagcugugag 60guuuuaucug ugcagcccuu cucugaggau ggacacuucu cacacuacaa aguccuguuu 120gcugauucuu cuuguggccc uacugugugc agaaagagcu cagggacugg aguguuacca 180gugcuaugga gucccauuug agacuucuug cccaucaauu accugccccu acccugaugg 240agucuguguu acucaggagg cagcaguuau uguggguucu caaacaagga aaguaaagaa 300caaucuuugc uuacccaucu gcccuccuaa uauugaaagu auggagaucc uggguacuaa 360ggucaaugug aagacuuccu guugccagga agaccucugc aaugcagcag uucccaaugg 420aggcagcacc uggaccaugg caggggugcu ucuguucagc cugagcucag uccuccugca 480gaccuugcuc ugaugguccu cccaaugacc uccacccuug uccuuuuauc cucaugugca 540acaauucuuc cuggagcccu cuagugauga auuaugaguu auagaagcuc caagguggga 600guagugugug aaauaccaug uuuugccuuu auagcccugc uggguaggua ggugcucuaa 660uccucucuag ggcuuucaag ucuguacuuc cuagaauguc auuuuguugu ggauugcugc 720ucaugacccu ggaggcacac agccagcaca gugaagaggc agaauuccaa gguauuaugc 780uaucaccauc cacacauaag uaucuggggu ccugcaaugu ucccacaugu auccugaaug 840ucccccuguu gaguccaaua aacccuuugu ucuccc 8762606929RNAHomo sapiensmisc_feature(2080)..(2080)n is a, c, g, or umisc_feature(2082)..(2082)n is a, c, g, or umisc_feature(4019)..(4019)n is a, c, g, or umisc_feature(4119)..(4119)n is a, c, g, or umisc_feature(5039)..(5039)n is a, c, g, or umisc_feature(5048)..(5048)n is a, c, g, or umisc_feature(5054)..(5054)n is a, c, g, or umisc_feature(5079)..(5079)n is a, c, g, or umisc_feature(5131)..(5131)n is a, c, g, or u 260ggaagaaaga gagggaggga aaagagaagg aaggaguaga ugugagaggg uggugcugag 60ggugggaagg caagagcgcg aggccuggcc cggaagcuag gugaguucgg cauccgagcu 120gagagacccc agccuaagac gccugcgcug caacccagcc ugaguaucug gucuccgucc 180cugaugggau ucucgucuaa accgucuugg agccugcagc gauccagucu cuggcccucg 240accagguuca uugcagcuuu cuagaggucc ccagaagcag cugcuggcga gcccgcuucu 300gcaggaacca auggugagca gggcaaccug gagaggggcg cuauucugag gauucgaggu 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4620ccggauuaca ugagggaucu uuaccggcuc cagucugggg aggaggagga ggaagagcag 4680agccagggaa ccgggcuuga guacccggag cgucccgcca gccgagccaa cacugugagg 4740aguuuccauc acgaagguca guuucugcuc uuaguccugg cgguguaggg ugggguagag 4800crccggggca gagggugggg ggugggcagc uggcagggca agcugaaggg guuguggaag 4860cccccgggga agaagaguuc auguuacauc aaagcuccga guccuggaga cuguggaaca 4920gggccucuua ccuucaacuu uccagagcug ccucugaggg uacuuucugg agaccaagua 4980guggugguga ugggggaggg gguuacuuug ggagaagcgg acugacacca cucagacunc 5040ugcuaccncc cagngggugu ucuuuagcua uaccaaagnc agggauucug cccguuuugu 5100uccaaagcac cuacugaauu uaauauuaca ncuguguguu ugucagguuu aucaauaggg 5160gccuuguaau acgaucugaa uguuuccuag cggauguuuc uuuuccaaag uaaaucugag 5220uuauuaaucc uccagcauca uuacuguguu ggaauuuauu uucccuucug uaacaugauc 5280aacaaggcgu gcucuguguu ucuaggaucg cuggggaaau guuugguaac auacucaaaa 5340guggagaggg agagagggug gccccucuuu uucuuuacaa ccacuuguaa agaaaacugu 5400acacaaagcc aagagggggc uuuaaaaggg gaguccaagg gugguggagu aaaagaguug 5460acacauggaa auuauuaggc auauaaagga gguugggaga uacuuucugu cuuugguguu 5520ugacaaaugu gagcuaaguu uugcugguuu gcuagcugcu ccacaacucu gcuccuucaa 5580auuaaaaggc acaguaauuu ccuccccuua gguuucuacu auauaagcag aauucaacca 5640auucugcuau uuuuuguuuu uguuucuugu uuuuguuuug uuugguuuuu uuuuuuuuuu 5700uuuuuuuuuu gucucagaaa agcucauggg ccuuuucuuu uccccuuuca acugugccua 5760gaacaucugg agaacauccc agggaccagu gagagcucug cuuuucguuu ccucuucaac 5820cucagcagca ucccagaaaa ugaggugauc uccucggcag agcuccggcu cuuucgggag 5880cagguggacc agggcccuga cugggaacag ggcuuccacc guauaaacau uuaugagguu 5940augaagcccc cagcagaaau gguuccugga caccucauca cacgacuacu ggacaccaga 6000cuaguccauc acaaugugac acggugggaa acuuucgaug ugagcccugc aguccuucgc 6060uggacccggg aaaagcaacc caauuauggg cuggccauug aggugacuca ccuccaccag 6120acacggaccc accagggcca gcaugucaga aucagccgau cguuaccuca agggagugga 6180gauugggccc aacuccgccc ccuccugguc acuuuuggcc augauggccg gggccauacc 6240uugacccgca ggagggccaa acguaguccc aagcaucacc cacagcgguc caggaagaag 6300aauaagaacu gccgucgcca uucacuauac guggacuuca gugacguggg cuggaaugau 6360uggauugugg ccccacccgg cuaccaggcc uucuacugcc auggggacug ucccuuucca 6420cuggcugauc accucaacuc aaccaaccau gccauugugc agacccuagu caacucuguu 6480aauucuagua ucccuaaggc cuguuguguc cccacugaac ugagugccau uuccauguug 6540uaccuggaug aguaugacaa ggugguguug aaaaauuauc aggagauggu gguagagggg 6600uguggaugcc gcugagauca gacaguccgg agggcggaca cacacacaca cacacacaca 6660cacacacaca cacacacaca cacguuccca uucaaccacc uacacauacc acacaaacug 6720cuucccuaua gcuggacuuu uaucuuaaaa aaaaaaaaaa gaaagaaaga aagaaagaaa 6780gaaaaaaaau gaaagacaga aaagaaaaaa aaaacccuaa acaacucacc uugaccuuau 6840uuaugacuuu acgugcaaau guuuugacca uauugaucau auuuugacaa auauauuuau 6900aacuacauau uaaaagaaaa uaaaaugag 6929261277RNAHomo sapiens 261gaaucccacu uacaugcgag caucucuaua uacauccuca aucuaucccc ucgaauccac 60ggacuuauca gucaaucaau acuacaguca aagaauuuuu uucuacguua uccuggagca 120uugcgcuggc accucuuuuu cuaaucaucu ugguuguggg gccaauaugg augcgcagac 180gguguaaacg cagggcugga aagacauaug gacugaccaa gcuacggacu gacaaccagg 240acuucccuuc cagcccaaac uaaauaaagg aaaugaa 2772622810RNAHomo sapiens 262gaauucaugu cuuacgguca aggcagaggg cccagcgcca cugcagccgc gccaccuccc 60agggccgggc cagcccaggc guccgcgcuc ucggggugga cuccccccgc ugcgcgcuca 120agccggcgau ggcuccucuc ggauaccucu uagugcucug cagccugaag caggcucugg 180gcagcuaccc gaucuggugg uccuuggcug ugggacccca guacuccucu cugagcacuc 240agcccauucu cugugccagc aucccaggcc ugguaccgaa gcagcugcgc uucugcagga 300acuacgugga gaucaugccc agcguggcug agggugucaa agcgggcauc caggagugcc 360agcaccaguu ccgaggccgg cguuggaacu gcaccaccgu cagcaacagc cuggccaucu 420uuggcccugu ucuggacaaa gccacccggg agucagccuu uguccaugcc aucgccuccg 480cuggaguagc uuucgcagug acacgcuccu gugcagaggg aucagcugcu aucugugggu 540gcagcagccg ccuccagggc uccccaggcg agggcuggaa guggggcggc uguagugagg 600acauugaauu uggaggaaug gucucucggg aguuugccga ugccagggag aaccggccgg 660augcccgcuc ugccaugaac cgucacaaca augaggcugg gcgccaggcc aucgccaguc 720acaugcaccu caagugcaaa ugccacgggc uaucuggcag cugugaagug aagaccugcu 780gguggucgca gccggacuuc cgcaccaucg gggauuuccu caaggacaag uaugacagug 840ccucggagau ggugguagag aaacaccgag agucucgugg cuggguggag acccugaggc 900cacguuacac guacuucaag gugccgacag aacgcgaccu ggucuacuac gaggccucac 960ccaacuucug cgaaccuaac cccgaaaccg gcuccuucgg gacgcgugac cgcaccugca 1020augugagcuc gcauggcaua gaugggugcg accuguugug cugcgggcgc gggcauaacg 1080cgcgcacuga gcgacggagg gagaaaugcc acuguguuuu ccauuggugc ugcuacguca 1140gcugccagga gugcacacgu gucuaugacg ugcacaccug caaguaggag agcuccuaac 1200acgggagcag gguucauucc gaggggcaag guuccuaccu gggggcgggg uuccuacuug 1260gaggggucuc uuacuugggg acucgguucu uacuugaggg cggagauccu accugugagg 1320gucucauacc uaaggacccg guuucugccu ucagccuggg cuccuauuug ggaucugggu 1380uccuuuuuag gggagaagcu ccugucuggg auacggguuu cugcccgagg guggggcucc 1440acuuggggau ggaauuccaa uuugggccgg aaguccuacc ucaauggcuu ggacuccucu 1500cuugacccga cagggcucaa auggagacag guaagcuacu cccucaacua ggugggguuc 1560gugcggaugg gugggagggg agagauuagg gucccuccuc ccagaggcac ugcucuaucu 1620agauacauga gagggugcuu cagggugggc ccuauuuggg cuugaggauc ccgugggggc 1680ggggcuucac cccgacuggg uggaacuuuu ggagaccccc uuccacuggg gcaaggcuuc 1740acugaagacu caugggaugg agcuccacgg aaggaggagu uccugagcga gccugggcuc 1800ugagcaggcc auccagcucc caucuggccc cuuuccaguc cugguguaag guucaaccug 1860caagccucau cugcgcagag caggaucucc uggcagaaug aggcauggag aagaacucag 1920gggugauacc aagaccuaac aaaccccgug ccuggguacc ucuuuuaaag cucugcaccc 1980cuucuucaag ggcuuuccua gucuccuugg cagagcuuuc cugaggaaga uuugcagucc 2040cccagaguuc aagugaacac ccauagaaca gaacagacuc uauccugagu agagaggguu 2100cucuaggaau cucuaugggg acugcuagga aggauccugg gcaugacagc cucguaugau 2160agccugcauc cgcucugaca cuuaauacuc agaucucccg ggaaacccag cucauccggu 2220ccgugauguc caugccccaa augccucaga gauguugccu cacuuugagu uguaugaacu 2280ucggagacau ggggacacag ucaagccgca gagccagggu uguuucagga cccaucugau 2340uccccagagc cugcuguuga ggcaaugguc accagauccg uuggccacca cccugucccg 2400agcuucucua gugucugucu ggccuggaag ugaggugcua cauacagccc aucugccaca 2460agagcuuccu gauugguacc acugugaacc gucccucccc cuccagacag gggaggggau 2520guggccauac aggagugugc ccggagagcg cggaaagagg aagagaggcu gcacacgcgu 2580ggugacugac ugucuucugc cuggaacuuu gcguucgcgc uuguaacuuu auuuucaaug 2640cugcuauauc cacccaccac uggauuuaga caaaagugau uuucuuuuuu uuuuuuucuu 2700uucuuucuau gaaagaaauu auuuuaguuu auaguauguu uguuucaaau aauggggaaa 2760guaaaaagag agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 28102632948RNAHomo sapiens 263cgcaccggag guccacacug ccgcguggac uccagcgaug gcgcugcgcu aggcuagcgg 60gugccaggau cccucucugc guccugugcg cgggaagagc ucuggagaac cagaguugca 120uucuggaguu gaagacucau ggcacagacu guuagagaau gcucauuggc acuucuuuuu 180uuguucaugu ggcugcugau uaaagcaaau auagaugugu gcaagcuugg cacugugacc 240guccagccug ccccugugau uccucuuggg ucagcugcca auauuuccug cuccuugaau 300cccaagcaag gcuguucaca uuaucccagu ucuaacgaau uaauccucuu aaaguuuguc 360aaugaugucc uuguugaaaa ucuccauggc aagaaagucc augaccacac uggucacucc 420uccacuuuuc aagucaccaa ccugucccuu gguaugaccu uguuugucug caagcuaaac 480uguagcaacu cucaaaagaa gccaccaguc ccaguaugug ggguggagau cucaguuggu 540guugcuccag agccaccuca aaacauauca uguguccagg aaggagaaaa uggaacugug 600gccuguuccu ggaacucugg aaaaguuacu uaucugaaaa ccaauuacac uuuacaguua 660aguggaccaa acaaucugac cugucagaaa caauguuuuu cugacaaucg ucagaauugc 720aaucgccugg aucuugggau caaucuaagc ccugauuuag cugaauccag guucauaguc 780cguguuacug ccaucaacga ucuuggaaau ucuucuucac uuccgcauac guucacguuc 840uuggacauag ugaucccucu uccuccgugg gacaucagaa ucaacuuucu aaaugcuucu 900gggagcagag guacacugca gugggaagau gaggggcaag ugguacucaa ucaacucaga 960uaucagccuc uuaacagcac guccuggaac auggucaaug cuacaaaugc caaaggaaaa 1020uaugaccugc gagaucugag accguuuaca gaauaugaau uucaaaucuc cucuaagcua 1080caucucucug gaggaaguug gaguaauugg agugagucac ugagaacacg aacaccagag 1140gaagagccug uugggauauu agacaucugg uacaugaaac aagacaucga cuaugacaga 1200cagcagaucu cucuuuucug gaagagucug aauccaucag aggcaagggg gaagauccuc 1260cacuaucagg ugacguuaca agaggugaca aagaaaacaa cacugcagaa uacuacaaga 1320cacaccuccu ggaccagggu caucccccga acuggggcuu ggacggcauc agugucugca 1380gccaacucaa aaggcgcuuc ugcacccacu cacauuaaca uaguggaccu auguggcacu 1440ggguugcugg cuccucacca ggucucugca aagucggaga acauggacaa cauucuagug 1500accuggcagc cuccuaagaa agcugauucu gcuguucggg aguacauagu ggaauggaga 1560gcucuccaac cagggagcau cacgaaguuu cccccacacu ggcugcggau ccccccggac 1620aacaugucug cucugauuuc agagaacaua aagcccuaua ucuguuauga aaucagggug 1680caugcacugu cagagagcca aggagggugc agcuccaucc ggggugacuc caagcacaaa 1740gcaccaguga guggcccuca cauuacugcc aucacagaga aaaaggaacg ccuuuucauu 1800uccuggaccc acauuccauu cccggagcaa aggggcugca uccuccauua cagaauauac 1860uggaaagaac gagacucgac agcacaaccu gagcucugcg aaauucagua ccgacgcucu 1920caaaacucac auccaauaag cagccuacag cccaggguga cauauguccu auggaugaca 1980gcugugacag cugcugguga aaguccccaa ggaaaugaaa gggaauuuug uccacagggc 2040aaagccaacu ggaaagcauu cgugauauca agcauuugca ucgcuaucau cacggugggc 2100acguucucaa uucguuacuu ccggcaaaag gcauuuacuc uccugucuac ucucaaaccu 2160caaugguaua gcagaaccau uccagaucca gcaaacagca cuuggguaaa gaaguauccc 2220auucuggagg agaagaucca gcuaccuacg gauaaucucc ugauggcaug gcccacuccu 2280gaagagccug agccccugau cauccaugaa guccucuacc acaugauccc aguugucaga 2340caaccauauu acuucaaaag aggccaagga uuccaaggcu acucuaccuc caagcaagau 2400gcaauguaua uugccaaucc acaagcuaca ggaacucuca cagcugagac cagacaacua 2460gugaaccuau acaaggugcu agaaagcaga gacccugacu caaaacuggc caaccugacc 2520agccccuuga cagucacccc agugaacuac cuuccuagcc

augaaggcua uuuacccucc 2580aacauagaag aucugucacc acaugaggcu gacccaacug auucuuuuga ccuggagcau 2640caacauauuu cucuuuccau uuuugcauca aguucucucc gcccacucau cuucgguggu 2700gagcggcuga cucuagaucg guuaaagaug ggcuaugacu cccucaugag uaaugaggcu 2760ugauacuaga aagccaacgu accucauuuu aucugcccag uuccuacucc aaaggucugu 2820gacagugaag acaagccagc ugucucugga uaaaguuagc uucaccauag guacuuaagu 2880cuuauggaua agguggcaau acaccaacac ugauaucaua uagaaaggac cccaagauag 2940ucaugcuc 29482642487RNAHomo sapiens 264ggcacgaguu cacccucugc augcguuccc cuccccccuc uccagcaaac acggcgcgcc 60aguccaaagc ggacucagug gccucgggga cgggagcaug ccaccuccug uggugacguc 120acuuggggua gaacccuuag acacuacaug gggggggggg guacagaacu cccgagccag 180gacagucacu cacucuucag gcgguggggc ugggccagac aguaccgccc ccaccgcgcc 240cgccucgcac acccucggaa gcgcaggcuc gcagcgcggc gcuggggugg gggguugcgc 300cccagaacuu cggccuccag uccccagccc gcugcaccuc cuuacccucu agaggccccc 360ucccccuuac ccucuagagg caccaggagu ugucgcaagg ggcccuuggg aaauucccug 420gaccccugug ccaggaggug cccgguucgc ccgcucccca uccacccccc cgagggcggu 480gcccgggggc gcugccccau ggagcgggga ggcgggcgcc gucugcugcg ggagcuguga 540ccugaguagg agcugugugu cgcagccgcc ccaccccugc cgaucaugcg ccggcgaccc 600ugguucgcca gucccacugg gcugugagcc ccccacuccu ggccugucac ggcccgcgcg 660ccaugggcag cgcccacccu cgccccuggc ugcggcuccc acaagggccc cagccgcggc 720cugaguucug ggcgcuccug uucuuccuac ugcugcuggc ugccgcugug cccaggucag 780cacccaacga cauccugggc cuccgccuac ccccagagcc cgugcucaac gccaacacag 840ugugccugac auugcccggc cugagccggc ggcagaugga ggugugugug cgucacccug 900acguggccgc cucugcuauc cagggcaucc agaucgccau ccaugagugc cagcaucagu 960uccgggacca gcgcuggaac ugcuccagcc uggagacucg gaacaaaguc cccuacgaga 1020gccccaucuu cagccgaggu uuucgagaga gugcuuucgc cuacgccaua gcagcugccg 1080ggguggugca cgcagugucc aacgcgugcg cucuggguaa acugaaggcu ugcgguugcg 1140acgccuccag acguggggac gaagaagcuu uccgucggaa gcugcaccgc uugcagcugg 1200acgcgcugca gcgcggaaag ggcuugagcc acgggguccc ugaacacccg gccauacuuc 1260cugccagccc aggucugcag gacuccuggg aguggggugg cugcaguccg gaugugggcu 1320ucggagaacg cuucucuaag gacuuucugg acucccgaga gccucacaga gacauccaug 1380cucgaaugag acuccacaac aaccgugugg gccggcaggc ggugauggag aacaugcggc 1440guaagugcaa augccacggc accucaggca gcugccagcu caagaccugc uggcagguga 1500cgccugaguu ccgcacagua ggggcgcugc ugcgcaaccg cuuccaccgc gccacgcuca 1560uccggccgca caaccgcaac gguggccagc uggagcccgg ccccgcggga gcacccucgc 1620cagcaccggg cacuccaggg cugcgccgca gggccagcca cuccgaccug gucuacuuug 1680agaaaucucc cgacuucugu gagcgcgagc cgcgccugga cucggcaggc acugugggcc 1740gccugugcaa uaagagcagc acgggucccg auggcugcgg cagcaugugc uguggccgcg 1800gccacaacau ucugcgccag acgcgcagcg agcgcugcca cugccgguuc cacuggugcu 1860gcuucguggu cugcgaagaa ugccgcauca ccgagugggu cagcgucugc aagugagcag 1920acccaagcuc cucugggucu caagaauggu uguccucuug gugccuggcu ucugccgcua 1980gcggaucuga gccaggcagc aagcagcagc cuuggcuccu gagagaggug guuggcucuu 2040acagccccga gggucuacaa ucaccagaca guccagaucu gauugacauu ccuccgcuca 2100ccucuguagg uuccccucuu ucuguuccua gcucagacag cuggggguga uaguggagac 2160uguuccacac ccuaggacag gucaccaaag cagcccagcc uggcaugccu accuccuguc 2220aucucuucuu cccuucccca ggagugauag gcaaugcacu gaagcugaug ggcaccgggg 2280aagaaaacua aaaggcagaa auggccguca ucgggcugaa gugacucuaa gggcuccaga 2340ccucugcucc ugucuuucac uuaacagaua uuuauuuuug cgcucucuuu gagacacucu 2400cuggggaaaa agaagcuccg gagucuacag gcugauuaag ggacauggac aauaaaccag 2460uaaacacaca aaaaaaaaaa aaaaaaa 24872652093RNAHomo sapiens 265gaauuccggg ccgcuugcac uuggcgacua gucugcggcg gacgugacgc caaggccacg 60ggcagcgcgg guccccuguc agaggugucc cucgcgcagg aaugggcccg caggcggcag 120cuggcaggau gauucugcug gugguccuga ugcugucugc gaaggucggg aguggagcuu 180ugacgagcac cgaggauccu gagccucccu cggugccugu accgacgaau guucuaauua 240agucuuauaa cuugaacccu gucguaugcu gggaauacca gaacauguca cagacuccua 300uuuuuacugu acagguaaag guguauucgg guuccuggac ugauuccugc accaacauuu 360cugaucauug uuguaauauc uaugaacaaa uuauguaucc ugauguaucu gccugggcca 420gaguuaaagc uaagguugga caaaaagaau cugacuaugc acggucaaaa gaguuccuua 480ugugccuaaa gggaaagguc gggcccccug gccuggagau caggaggaag aaggaagaac 540agcucuccgu ccucguauuu cacccugaag ucguugugaa uggagagagc cagggaacca 600uguuugguga cgggagcacc uguuacacau ucgacuauac uguguaugug gagcauaacc 660ggagugggga gauccuacau acgaaacaua cggucgaaaa agaagagugu aaugagacuc 720ugugugaguu aaacaucuca guauccacac uggauuccag auauuguauu ucaguagacg 780gaaucucauc uuucuggcaa guuagaacag aaaaaucgaa agacgucugu aucccuccuu 840uccaugauga cagaaaggau ucaauuugga uucugguggu ugcuccucuu accgucuuua 900caguaguuau ccugguauuu gcguauuggu auacuaagaa gaauucauuc aagagaaaaa 960gcauaauguu accuaagucc uugcucucug ugguaaaaag ugccacguua gagacaaaac 1020cugaaucgaa guauucacuu gucacaccgc accagccagc uguccuagag agugagacgg 1080ugaucuguga agagccccug uccacaguga cagcuccaga cagccccgaa gcagcagaac 1140aggaagaacu uucaaaagaa acaaaggcuc uggaggcugg aggaagcacg ucugccauga 1200ccccagacag cccuccaacu ccgacacaaa gacgcagcuu uucccuguua aguaguaacc 1260agucaggccc uuguagccuc accgccuauc acucccgaaa cggcucugac aguggccucg 1320ugggaucggg cagcuccaua ucggacuugg aaucucuccc aaacaacaac ucagaaacaa 1380agauggcaga gcacgacccu ccacccguga gaaaggcccc cauggccucc gguuaugaca 1440aaccgcacau guugguggac gugcuugugg auguuggggg gaaggagucu cucauggggu 1500auagacucac aggagaggcc caggagcugu ccuaaggucu cccgaggccu gcugguggua 1560aagaaacuga ccuuuuaggc aguuuuucug cauugauuuc augaaagaag cuauacauua 1620gcuaauacua accacauaga auaucagacu uagauacgug aauaaggauc cugugggcac 1680ugcugggucc acucugcaaa ugccaagacu aucaaaggaa cguauugucg cuucuggcuc 1740cuucccaggu gggcuagcau cugugaguuu gccucggcua gccuugcuuc cuacagccgc 1800cacugcuccu ccacccugau caucucacag gacagggugg accggguuuu uuuuuuuuuu 1860ucacacaccu uuguauaugu aaguucaugu auauaauaug uuuacauguu ucacuuugaa 1920cugaaagcua cucaaagcca gccguaaguc uaugguagaa ugugauggaa cauguuggug 1980gaagcuugua caauagaaca cauugguggg agcuuguaca uacuuuuuua uggagcauua 2040cuuacgauuu uuuaaguaaa auguuuugaa accaaaaaaa aaaaaaggaa uuc 2093266756RNAHomo sapiens 266augagacucc acagccucau ccugcucucc uuccuucucc uggcuacuca ggcguucuca 60gaaaagguca gaaagagagc caagaacgca ccacacagca cagcggagga ggggguagag 120gguucagcuc ccucguuagg gaaggcccag aauaagcaga gaagcaggac aucuaaaucu 180cugacgcaug gcaaguuugu caccaaagac caagccacau gcagaugggc ugugacugag 240gaggagcagg gcaucagccu gaagguccag ugcacacaag ccgaucagga guuuucuugu 300guuuuugcug gugacccaac ugacugccuu aaacacgaca aagaccagau cuacuggaaa 360cagguugccc gcacgcugcg caaacagaaa aauaucugca ggaacgccaa gagugucuug 420aagaccagag ugugcagaaa gagauuucca gagucuaacc ucaagcuggu gaaccccaac 480gcacguggaa acacgaagcc caggaaggag aaagcagagg ucuccgcaag ggagcacaac 540aagguccaag aagcugucuc cacggagcca aacaggguca aagaagacau cacacucaau 600ccagcugcga cccagaccau ggccauuaga gauccagagu gucuagagga uccagaugug 660cucaaccaga ggaagaccgc ccuggaguuc uguggggaau cuuggagcuc cauuugcaca 720uucuuccuca acauguuaca ggcgacauca ugcuaa 756267181RNAHomo sapiens 267aauucgucga caugcgccgu uccagugcau ggugugccaa cgcagcuucu cccgcuccga 60ccaccucgcg cugcacauga agcgccacca gaacugagcg agcgagcgcu gccccacccg 120ccugacgccu ugcaguccgc ucugccaucc uuuaaaccgc agaccuaacu ucauaaaaag 180a 1812682056RNAHomo sapiensmisc_feature(1942)..(1943)n is a, c, g, or u 268gcuaaacuau cccgcaaaga uuuuucuuuc cucccuaaac ccuccuuuuu gcucuccuuu 60ucuauacccu uaacugcaaa caaaccauua aacgaccccu cuccugggcc uccgacggca 120ggaguccgcg gaccucccag gccgacagcc cucccucuac ccgcgagguu ccgggccggg 180cgagagggcg cgagcacagc cgaggacaug gaggugacug cggaccagcc gcgcugggug 240agccaccauc accccgcggu ccucaacggu cagcacccag acacgcacca cccgggccuc 300ggccauucgu acauggaagc ucaguauccg cugacggaag agguggacgu acuuuuuaac 360aucgaugguc aaggcaacca cgucccgucc uacuacggaa acuccgucag ggcuacggug 420cagagguauc cuccgaccca ccacgggagc cagguaugcc gcccgccucu gcugcacgga 480ucucugcccu ggcuggaugg cggcaaagcc cugagcagcc accacaccgc cucgcccugg 540aaccucagcc ccuucuccaa gacguccauc caccacggcu cuccggggcc ucuguccguu 600uacccuccgg cuucauccuc uucucuggcg gccggccacu ccaguccuca ucucuucacc 660uucccgccca ccccgccgaa agacgucucc ccagacccgu cgcuguccac cccgggaucc 720gccgggucgg ccaggcaaga ugagaaagag ugccucaagu aucaggugca gcugccagau 780agcaugaagc uggagacguc ucacucucga ggcagcauga ccacccuggg uggggccuca 840uccucagccc accaccccau uaccaccuau ccgcccuaug ugcccgagua cagcucugga 900cucuucccac ccagcagccu gcugggagga uccccuaccg gguucggaug uaagucgagg 960cccaaggcac gauccagcac agaaggcagg gaguguguga acugcggggc aaccucuacc 1020ccacuguggc ggcgagaugg uaccgggcac uaccuuugca augccugcgg acucuaccau 1080aaaaugaaug ggcagaaccg gccccuuauc aagcccaagc gaaggcuguc ggcagcaagg 1140agagcaggga cauccugcgc gaacugucag accaccacca ccacccucug gaggaggaac 1200gcuaaugggg acccggucug caaugccugu gggcuguacu acaagcuuca uaauauuaac 1260agaccccuga cuaugaagaa agaaggcauc cagacccgaa accggaagau gucuagcaaa 1320ucgaaaaagu gcaaaaaggu gcaugacgcg cuggaggacu uccccaagag cagcuccuuc 1380aacccggccg cucucuccag acacauguca ucccugagcc acaucucucc cuucagccac 1440uccagccaca ugcugaccac accgacgccc augcauccgc ccuccggccu cuccuucgga 1500ccucaccacc cuuccagcau ggucaccgcc auggguuaga gaggcagagc ccugcuccac 1560augcgugagg agucuccaag ugugcgaaga guuccuccga ccccuucuac uugcguuuuu 1620cgcaggagca guaucaugaa gcccgaaagc gacagaucug uguuuuugaa ggcagaaagc 1680aaaauguuug cuucuuuuuu caaaggagcu cgagguggug ucugcauucc aaccacugaa 1740uccggauccc auuugugaau aagccauuca gacucauauu cccuauuuaa cagggucucu 1800agugcuguga aaaaaauauu gcugaacauu gcauauaacu uauauuguaa gaaauacugu 1860acauuugagg aagacuuuau uguaccugga uagcuguaag aaaggcauga aggacgccaa 1920gaguuuuaag gaauauaggg gnnuuaaagu auggagauac agaagaaacc acuaagucug 1980auguccaaau gggcacacug ucaguuuugu uucccuucag uuguuugaug cauuuaaaaa 2040aaaaaaaaag aaagaa 20562691508RNAHomo sapiens 269caaccaccuc cuaccugccu gcccaaagcu ccagggcugg agcacggaga ccugucaggg 60auggauuuug cccacaugua ccaaguguac aaguccaggc ggggaauaaa acggagcgaa 120gacagcaagg aaacuuacaa acugccgcac cggcugauug agaaaaagag acgugaccgg 180auuaacgagu gcauugccca gcugaaggau cuccuacccg aacaucucaa acuuacuacu 240uugggucacu uggaaaaagc agugguucug gagcuuacgu ugaagcacgu gaaagcauug 300acaaaucuaa uugaucagca gcagcagaaa aucauugccc ugcagagcgg uuuacaagcu 360ggugauuugu cgggaagaaa ucucgaggca gggcaagaaa uguucugcuc agguuuccag 420acuugugccc gugagguacu ucaguaccug gcgaagcaug 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1320gagaagauuc agagugugug ugagagugag ugagugugcg ugcgugcgug cuuguaugua 1380uguuuguaua uguaggacaa uaaguuccuu cugacacaag ggagacacga gaaggauagc 1440cugacaucag augacagacu ggaggacugu agcacaucuc ugggcguuuc ccuacccaga 1500gaagagcc 15082709471RNAHomo sapiensmisc_feature(121)..(121)n is a, c, g, or u 270agucaccgac guuguauaac gacggccagu gaauuguaau acgacucacu auagggcgaa 60uuggguaccg gccccccccu cgaggucgac gguaucgaua agcuugauau cgaauucucg 120nccgcgugcg ggucuggucg gggcggagcg aaggccgcgg guggccgugg ucgguccucc 180gcggcuaagg agccgagggc uccgacgcgg gcugcgcccg gugagcggcg gccagagcua 240acuugcgcug acuggaccag cugaggagcg gcccggcggg gcgacugcga gcuucaccga 300gaggcuucuc cgcccugguc cgcagucccg acggccgggc ggaccauggc guccucggcu 360caccugguca ccaucaagcg gagcggcgau gacggcgcac acuucccgcu gagccucagc 420uccugccugu uuggaaggag uauugaaugu gacauucgua uccagcugcc uguagugucu 480caaagacauu gcccaauugu aguccaagag caagaggcga uauuauauaa uuucaguucu 540accaauccaa cucaaguaaa cgggguuacu auagaugagc cugugaggcu gagacaugga 600gacauaauaa 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caaaaauagc ucugcagucu 5100ccacaaccag gacauaucau aaacccagca agcaugaaga gacaguccaa caugagucuc 5160aggaaagaca ugagagaauu uuccauacuu gaaaaacaaa cacagucacg aggcagagac 5220gcaggcacac cagcaccaau gcaggaagaa aauggcacca cagccauuau ggaaacacca 5280aagcagaaac uggauuucau aggaaauuca acaggacaua agaggaggcc ucggacaccc 5340aaaaacaggg cucagccccu agaagaccug gauggcuucc aagaacucuu ucaaacacca 5400gcuggugcca gugacccugu gaguguugaa gaaagugcaa agauaucuuu ggcaucuuca 5460caagcagaac cagucagaac cccagcaagu acaaagagac gcuccaagac aggucucagu 5520aaaguggaug ugagacaaga accuucaaca cuugggaaaa gaaugaaguc acuaggcaga 5580gccccaggca caccagcacc agugcaggaa gaaaaugaca gcacagccuu cauggaaacu 5640ccaaagcaga aacuggauuu cacaggaaau ucaucaggac auaagaggag gccacagaca 5700ccuaagauca gggcucagcc ccuagaagac cuggauggcu uccaagaacu cuuccaaaca 5760ccagcuggug ccaaugacuc agugacuguu gaggaaagug uaaagauguc uuuggaaucu 5820ucacaagcag aaccagucaa aaccccggca agcacaaaga gacucuccaa gacaggucuc 5880aguaaggugg augugagaga agacccuuca auacuugaga aaaaaacaaa 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gcgcucuuua gcaccaaagc aggaagcaac agaugagaag 8520ccuguaccug agaaaaaaag ggcugcuucc agcaagaggu auguaucacc ugagccugug 8580aagaugaaac accugaaaau cgugucaaac aaacuugaau cuguggaaga gcagguuagc 8640acuguuauga aaacagaaga aauggaagcc aaaagagaaa auccugucac uccagaucag 8700aacucuaggu accgaaagaa aaccaaugua aaacagccaa ggcccaaguu ugaugcaucu 8760gcagagaaug ucgggauaaa gaaaaacgag aagacuauga agacugccuc ccaggagaca 8820gagcugcaga auccagauga uggagccaag aaaucuacau cucggggcca agucaguggg 8880aaaagaacau gcuugagguc uagaggaacg acugagaugc cccagccuug ugaagcagaa 8940gagaaaacaa gcaaaccagc ugcagaaauc uugauaaagc cucaggaaga gaaaggaguc 9000ucuggagagu cugauguuag guguuugagg uccagaaaaa cuagagucgc uuuggacagu 9060gaaccuaagc caaggguaac ucguggaacc aagaaagaug caaaaacucu gaaggaggau 9120gaagacauug uaugcaccaa gaaguuaaga acaagaaguu aagaacaaga aguuaccaga 9180aaagugaaac uauguagcaa agacauuuaa gaaggaaaag uaaauuugac uuagugauaa 9240guuccagugu gguuuucacc uccaguguaa agaugaacug uaaauacuac ugcuacugcc 9300ugaguuuaag gaaggaagcu uugagcuuuc cuggucauac ucucuucaga cgccaaugga 9360ggucaugagg aagaucacca gggaucucag cgcaauuaca guuuaggggu gagcaggcag 9420aaauguggcc cucuguccua uccaauaaag cucugaaauu cgcugccaaa a 9471271463RNAHomo sapiens 271gacguagagc cccuugcgcc cgguuuccug aucccgcuua cuccucugcg cgccggcagg 60auggcccaca agcagaucua cuacucagac aaguacuucg augagcacua cgaguaccgg 120caugucaugu uacccagaga acucucuaaa caaguaccca aaacucaucu gauguccgaa 180gaggagugga ggagacuugg uguccaacag agucuaggau ggguucauua caugauucau 240gagccagaac cgcauauucu ucucuuuaga cgaccucuuc caaaagaaca acaaaaauga 300agugcagcug ggaucaucua aucuuuuuca aauuuaaugu auauguguau auaagguagu 360auucagugaa uacuugaaaa guguacaaac cuuucaucca uaccugugca ugcgcuguau 420ucuucacagc aacagagcuc agucaaaugc aacugcaagu agg 4632721280RNAHomo sapiens 272cuacccuaga caaucacggc uuagccggcg cgcggagucg aucgucucgg ucgcuagagc 60uguccugagc ucgaacgguc cgacgccccc gccgcgccgg uccgugacgc cggggccgac 120acgaugaagg auuugggggc caagcacuug gcagguggcg aagggguuca gcuuuucgga 180uuguugaacu ucuaccugga acaagaacag agauaccaac cucgggaaaa agggcugauc 240uugauggagg cuaccccgga gaaugauaac acuuuguguu caagacugag aaaugccaaa 300guggaagauu uaagaaguuu aacuaacuuc uuuggaucug gcacugaaac uuucguucug 360gcugucaaua uuuuggauag auucuuggcc cuuaugaagg ugaaaccgaa acaccugucc 420ugcauuggcg ucugcugcuu uuugcuggcc gccaggcugg cggaagaaga aggugacguu 480ccccccacgc acgacgugau ccgcaucagu caguguaaau gcacagcguc ugacauuaaa 540cgcauggaga aaaucaucuc agagaaacug cacuaugagc uggaagcuac cacugccuua 600aacuuuuugc acuuguacca cgcgauugua uuuugucaca cuucagaaag gaaggagauu 660cucagccucg auaaacucga agcgcagcug aaagcuugca acugccgagu ugucuucucc 720aaagcaagac caucuguauu agcucugugc cuucucaauu uggaaauaga aacgauaaaa 780uccguggaac ugcuggaaau ucucuugcuu guuaaaaaac auuugaagcu cagcgacacu 840gaauucuuuu acuggaggga acugguuucu aaaugucuag cagaguauuc uucgccucgc 900ugcugcaagc cugaucugaa gaagcuggua uggauuguuu cgcgacgcac ugcgcagaac 960cuccacagca gcuacuacag uguuccugag cugcccacua ucccagaggg ggguugcuuu 1020gacggaagug aaagugagga cucuggugaa gacaugaguu guggagagga gagucucagc 1080agcuccccac ccagcgauca ggagugcacc uucuucuuug acuuccaagu ggcucagaca 1140cugugcuuuc caccauagag gaaucugaca uuguucugug ucagggaauu uauaagugug 1200uguaccuagg uuucaaagca auaaacuugg ggguugaaua ggguaguuuu ccuagguuuc 1260cagccccccg ucuagucagg 1280273291RNAHomo sapiens 273aacuaccuug ggcagguucu auuaacugca ccuaacucag acgugaguag gacagaagga 60agcugucccg ggcgaacuga ggucacaaag acuugcuuuu gauucaagag agaccuuaaa 120ggcuaguuau gauaguuaag uacaaguuuu aacaucuggu agcuaacuuu uuuucucuac 180cccguaauuc uacuaugacu gcucuucuag agguccugag uucaaauccc agcaaccaca 240ugguggcuca caaccaucua uaaugggauc ugaugcccuc uucuggugug c 291

Claims

1-37. (canceled)

38. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) wounding an area of the balding scalp of said human subject by disrupting an epidermis or dermis of the area of the balding scalp, thereby creating a wounded area; and (b) contacting the wounded area with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.

39. The method of claim 38, wherein said wounding is performed with a tool that comprises sandpaper, a laser, a Fraxel laser, a CO.sub.2 laser, an excimer laser, a felt wheel, a dermabrasion device, a light-based method, irradiation with visible light, irradiation with infrared light, irradiation with ultraviolet radiation, orthovoltage radiation, xray radiation, a surgical tool, a dermal biopsy punch, or is performed with a burn treatment or chemical treatment.

40. The method of claim 39, wherein said dermabrasion device is a micro-dermabrasion device.

41. The method of claim 38, wherein said wounding is dermabrasion.

42. The method of claim 38, wherein the wounding-step comprises disrupting the epidermis and dermis of the area of the balding scalp.

43. The method of claim 38, in which only part of the epidermis is removed.

44. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with a precursor cell, an inductive cell, or a hair follicle or a portion thereof.

45. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with one or more of the following compounds: finasteride, dutasteride, fluridil, spironolactone, cyproterone acetate, bicalutamide, flutamide, nilutamide, an inhibitor of an androgen receptor, an androgen antagonist, or an anti-androgen.

46. The method of claim 45, wherein said wounding-step is performed between 3-12 days, 4-12 days, 5-12 days, 4-11 days, 6-11 days, 6-10 days, 6-9 days, 6-8 days, 7-8 days, 5-11 days, 5-10 days, 7-10 days, or about 1 week prior to said contacting step.

47. The method of claim 38, wherein said area of the balding scalp is subjected to depilation or administration of a retinoid prior to said wounding.

48. The method of claim 47, wherein said depilation is performed by plucking, waxing, abrasion, laser, electrolysis, or administration of thioglycolic acid on said area of the balding scalp.

49. The method of claim 38, wherein said wounded area of the balding scalp is not surgically closed, or not contacted with a bandage, dressing, or ointment that facilitates wound healing for a period of time following said wounding-step.

50. The method of claim 49, wherein said period of time is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks.

51. The method of claim 38, wherein said wounded area of the balding scalp is allowed to heal by secondary intention.

52. The method of claim 38, wherein the method is performed on a subject with androgenetic alopecia (AGA), scarring alopecia, male pattern baldness, female pattern baldness, discoid lupus erythematosis, or lichen planopilaris.

53. The method of claim 38, wherein said treatment results in an increase in markers of hair follicle proliferation, hair follicle differentiation or hair follicle embryonic development.

54. The method of claim 38, wherein said treatment results in an increase in the amount of pigmented hair or an increase in hair follicle size.

55. The method of claim 38, wherein said treatment results in differentiation of an uncommitted epidermal cell into a hair follicle cell.

56. The method of claim 38, wherein said treatment results in generation of a hair follicle in the scalp of the subject.

57. The method of claim 38, wherein said wounding does not result in bleeding.

58. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) perforating an area of the balding scalp of said human subject, thereby generating a disrupted epidermis or dermis area of the balding scalp; and (b) contacting the disrupted epidermis or dermis area of the balding scalp with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.

59. The method of claim 38, wherein said compound or factor is a Wnt7 protein or a nucleic acid molecule encoding said Wnt7 protein.

60. The method of claim 38, wherein the step of disrupting said epidermis comprises the disruption of the basal and suprabasal epidermal layers.