Use of a Fibrinogen Capture Agent to Detect a Ciz1 B-Variant

Abstract

The present invention relates to the use of a fibrinogen capture agent or a fibrinogen detection agent in an assay to detect a Ciz1 b-variant.

Description

FIELD OF THE INVENTION

[0001] The present invention relates to assays and methods useful for the detection of Cip1-interacting zinc finger protein (Ciz1) in a sample. In particular, the present invention relates to the use of such assays and methods for the diagnosis of cancer.

BACKGROUND OF THE INVENTION

[0002] Cip1-interacting zinc finger protein 1 (Ciz1) (as exemplified by NCBI Reference Sequence: NM_001131016.1) is required for cell proliferation. Ciz1 localises to nuclear matrix bound foci that form sites of DNA replication during early S phase and promotes the initiation of DNA replication in association with cell cycle regulators including cyclin A/cyclin dependent kinase (CDK)2, cyclin E/CDK2 and p21cip1. In the context of transcription, CIZ1 is an oestrogen responsive gene that is itself a positive cofactor of the oestrogen receptor (ER), capable of enhancing the recruitment of ER to target chromatin. Ciz1 is alternatively spliced to produce conserved isoforms in mouse and man. Normal Ciz1 protein comprises at least two defined functional domains, a `replication` domain and an `immobilisation` domain.

[0003] Alternative splicing of Ciz1 exon 14 to generate a Ciz1 b-variant has been determined in various cancers, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), lymphomas, thyroid, kidney and liver cancer. Excess expression of either the replication or immobilisation domain of Ciz1 has also been demonstrated in cancers, for example in NSCLC, breast, colon, kidney, liver, bladder and thyroid cancers. A correlation of domain expression with the stage of the cancer has also been determined (see WO 2012/078208).

[0004] The present invention addresses the continued need to develop diagnostic tests and treatments that improve the survival rates of patients suffering from cancers such as lung cancer through novel biomarkers and targets.

SUMMARY OF THE INVENTION

[0005] The present inventors have determined that Ciz1 b-variant exists in a complex with fibrinogen. This has allowed the inventors to develop a novel assay for detecting the presence of Ciz1 b-variant in a subject.

[0006] Furthermore, the present inventors have determined that Ciz1 b-variant may exist as peptide fragments. Furthermore, the present inventors have determined that Ciz1 b-variant and/or fibrinogen/Ciz1 b-variant complexes may exist in the exosomal compartment of a blood sample.

[0007] These findings instruct the design of assays for the detection of Ciz1 b-variant peptides, either when alone or when in complex with fibrinogen.

[0008] In particular, the finding that Ciz1 b-variant is complexed with fibrinogen has enabled the provision of a detection assay, in particular a diagnostic assay, which utilises the capture of fibrinogen or Ciz1 b-variant as an initial step in order to isolate the fibrinogen/Ciz1 b-variant complex. The assay may involve the use a fibrinogen capture agent to isolate the fibrinogen/Ciz1 b-variant complex followed by the use of Ciz1 b-variant detection agent to detect the Ciz1 b-variant which may be within said isolated complex. Alternatively, the assay may involve the use a Ciz1 b-variant capture agent to isolate the fibrinogen/Ciz1 b-variant complex followed by the use of fibrinogen detection agent to detect the fibrinogen which may be within said isolated complex.

[0009] Thus, in a first aspect the present invention relates to the use of a fibrinogen capture agent or a fibrinogen detection agent in an assay to detect a Ciz1 b-variant.

[0010] As used herein, a capture agent refers to an agent which is used to isolate (i.e. enrich) the fibrinogen/Ciz1 b-variant complex from a sample. For example, the sample may be a sample which has been isolated from a subject. In particular, the sample may be a blood sample (e.g. a plasma sample) which has been isolated from a subject.

[0011] As used herein, a detection agent refers to an agent which is used to bind the fibrinogen/Ciz1 b-variant complex after it has been isolated (i.e. enriched) from a sample using a capture agent. As such, the detection agent is typically used after a capture step to determine the presence of the isolated (i.e. enriched) fibrinogen/Ciz1 b-variant complex.

[0012] Suitably, the assay may be an enzyme-linked immunosorbent assay.

[0013] The fibrinogen capture agent or fibrinogen detection agent may be an antibody or a fragment thereof, non-protein scaffold, aptamer or Ciz1 b-variant peptide which specifically binds fibrinogen.

[0014] In a preferred embodiment, the fibrinogen capture agent or fibrinogen detection agent is an antibody or a fragment thereof which specifically binds fibrinogen. In another preferred embodiment, the fibrinogen capture agent is a Ciz1 b-variant peptide which specifically binds fibrinogen.

[0015] The fibrinogen may be fibrinogen alpha chain.

[0016] The Ciz1 b-variant may be detected in a sample from a subject, for example a blood, urine, saliva or bronchoalveolar lavage sample.

[0017] In a preferred embodiment the sample is a blood sample from a subject. In a particularly preferred embodiment the sample is a plasma sample.

[0018] The Ciz1 b-variant may be detected by a method which comprises the following steps: a) capturing a fibrinogen/Ciz1 b-variant complex using a fibrinogen capture agent; and b) detecting Ciz1 b-variant using a Ciz1 b-variant detection agent; or a) capturing a fibrinogen/Ciz1 b-variant complex using a Ciz1 b-variant capture agent; and b) detecting fibrinogen using a fibrinogen detection agent.

[0019] The Ciz1 b-variant capture agent may be an antibody or a fragment thereof, or a non-protein scaffold which specifically binds Ciz1 b-variant.

[0020] The Ciz1 b-variant capture agent may be an antibody or a fragment thereof which specifically binds Ciz1 b-variant.

[0021] In a further aspect the present invention relates to a method of diagnosing cancer in a subject which comprises detecting a Ciz1 b-variant peptide in a sample from the subject, wherein the presence of Ciz1 b-variant peptide in the sample indicates that the subject has cancer and wherein the method comprises the step of capturing a fibrinogen/Ciz1 b-variant peptide complex from the sample.

[0022] In a further aspect the present invention relates to a method of diagnosing cancer in a subject which comprises detecting a Ciz1 b-variant peptide in a sample from the subject, wherein the presence of Ciz1 b-variant peptide in the sample indicates that the subject has cancer and wherein the Ciz1 b-variant peptide is the sequence shown as SEQ ID NO: 11 or a fragment thereof which comprises EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

[0023] In another aspect the present invention relates to method of detecting a Ciz1 b-variant peptide in a sample, for example detecting a Ciz1 b-variant peptide in a sample from a subject, wherein the method comprises the step of capturing a fibrinogen/Ciz1 b-variant peptide complex from the sample.

[0024] The method may comprise the steps of capturing a fibrinogen/Ciz1 b-variant complex using a fibrinogen capture agent; and detecting Ciz1 b-variant using a Ciz1 b-variant detection agent; or capturing a fibrinogen/Ciz1 b-variant complex using a Ciz1 b-variant capture agent; and detecting fibrinogen using a fibrinogen detection agent.

[0025] Suitably, the step of detecting the Ciz1 b-variant peptide or fibrinogen may employ antibody-based arrays, enzyme linked immunosorbent assays (ELISA), non-antibody protein scaffolds, radioimmuno-assay (RIA), western blotting, aptamers or mass spectrometry.

[0026] The method may further comprise the step of releasing a Ciz1 b-variant peptide and/or a fibrinogen/Ciz1 b-variant peptide complex from an exosomal component of the sample.

[0027] The Ciz1 b-variant peptide and/or fibrinogen/Ciz1 b-variant peptide complex may be released from the exosomal component by detergent treatment, such as SDS treatment.

[0028] The method may further comprise the step of enriching the exosomal fraction from the sample.

[0029] For example, the step of enriching the exosomal fraction may comprise ultracentrifugation, ultrafiltration, continuous flow electrophoresis, chromatography or cross-flow ultrafiltration.

[0030] The cancer may be selected from lung, lymphoma, kidney, breast, liver, bladder, ovarian or thyroid cancer.

[0031] In particular, the cancer may be lung cancer.

[0032] The present invention further relates to a method for treating a subject with cancer comprising administering to the subject a cancer therapeutic; wherein the subject has been identified as having cancer by the method of the invention.

[0033] The present invention also provides an anticancer drug for use in treating cancer wherein the subject has been identified as having cancer by the method of the invention.

[0034] The present invention further provides an anticancer lung cancer drug for use in treating lung cancer wherein the subject has been identified as having lung cancer by the method of the invention.

[0035] In a further aspect the present invention provides the use of a detergent to release a Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment of a sample.

[0036] In another aspect the present invention relates to a method for detecting a Ciz1 b-variant in a sample which comprises the step of releasing the Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment of the sample by treating the sample with detergent and detecting if the Ciz1 b-variant is present in the sample. The method may further comprise the step of enriching the exosomal fraction from the sample prior to releasing the Ciz1 b-variant.

[0037] The step of enriching the exosomal fraction may comprise ultracentrifugation, ultrafiltration, continuous flow electrophoresis, chromatography or cross-flow ultrafiltration.

[0038] In a further aspect the present invention provides a kit comprising an agent which specifically binds fibrinogen and an agent which specifically binds Ciz1 b-variant.

[0039] The fibrinogen may fibrinogen alpha chain.

[0040] The agent which specifically binds fibrinogen and/or the agent which specifically binds Ciz1 b-variant may be an antibody or a fragment thereof, a non-protein scaffold or an aptamer.

[0041] The agent which specifically binds to fibrinogen may be a Ciz1 b-variant peptide.

[0042] According to any of the above aspects of the present invention, the Ciz1 b-variant may be a Ciz1 b-variant peptide shown as SEQ ID NO: 11 or a fragment thereof which comprises EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

DESCRIPTION OF THE DRAWINGS

[0043] FIG. 1--a) Ciz1 b-variant epitope-containing species, detected with splice junction-selective anti-Ciz1 rabbit polyclonal antibody 043. 043 was generated and validated as described for antibody 2B (Higgins et al.; (2012); PNAS; Nov 6; 109(45):E3128-35) and is capable of detection of Ciz1 b-variant by western blot in plasma from lung cancer patients. Western blots were performed and show Ciz1 b-variant in 0.5 ul of representative samples from 5 patients with lung carcinomas (various stages) and five from individuals with no disease. b) Separation of plasma from lung cancer patients into the exosomal compartment and soluble compartment illustrated here using Invitrogen Total Exosome Isolation Kit (Catalog Number 4484450) used as recommended by the manufacturer. Fractions were separated by SDS-PAGE, and probed with 043 to reveal Ciz1 b-variant, or with `generic` Ciz1 antibodies that recognizes an epitope elsewhere in the protein (data shown here is generated with NB100-74624 (Nov4), Novus Biologicals that detects the C-terminus of Ciz1). Lane 1, untreated plasma (0.5 ul), lane 2 after low speed clearing spin (0.5 ul), lane 3 after high speed clearing spin (0.5 ul), lane 4 after addition of exosome reagent (0.5 ul equivalent), lane 5 high speed spin supernatant (SN, 0.5 ul equivalent), lane 6 high speed spin pellet (0.5 ul equivalent), lane 7 high speed spin pellet (P, 1 ul equivalent), lane 8 high speed spin pellet (2 ul equivalent). Red arrows indicate key lanes, showing different partitioning of Ciz1 epitopes. M, molecular weight marker. c) Comparison of type 1 plasma samples in which Ciz1 b-variant is exclusively in the exosome fraction, and rare patients who display a type 2 pattern in which a fraction of Ciz1 b-variant is in the soluble fraction. d) Quantitative immuno-analysis generated using a prototype sandwich ELISA (without treating samples with detergent) showing increased signal in the type 2 plasma sample illustrated in c. e) Partitioning of Ciz1 b-variant in naive type 1 plasma, and after treatment with 3% SDS (tested in the presence of protease inhibitor, PI, or 10 mM EDTA), revealing a shift of epitope into the soluble fraction. Blue arrows indicate soluble fraction after application of exosome isolation protocol. MW markers are shown to the right. SN=supernatant, P=pellet (exosome). f) Enhanced cancer-specific signal in SDS-treated type 1 plasma in ELISA immunoassay.

[0044] FIG. 2--Ciz1 Sequences

[0045] FIG. 3--Ciz1 b-variant .about.65-70 kDa species is a Ciz1 b-variant peptide stably bound to a carrier protein, which may augment antigenicity of Ciz1 b-variant peptide. a) Western blot illustrating cancer-selective epitope recognised by anti-Ciz1 b-variant antibody 2B, as described previously (Higgins et al; as above). b) Reconstitution of a Ciz1 b-variant epitope from synthetic b-variant peptide (50 nmols of EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVRSRDISREEWKGSETYSPNTAYGV DFLV--SEQ ID NO: 12) mixed with 0.5 ul of non-cancer plasma. Free peptide migrates with mobility indicative of a MW 3-4.times. greater than predicted (.about.30 kDa instead of 7.6 kDa), indicated by blue arrow. When incubated in plasma mobility decreases, antigenicity increases, and a new species is created at .about.80 kDa, indicated by red arrow. c) Similar results were generated with a separate anti-Ciz1 b-variant monoclonal antibody. d) For reference, a duplicate blot is probed with a monoclonal antibody that is selective for the exon 14a version of the peptide (EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQRSRDISREEWKGSETYS PNTAYGVDFLV--SEQ ID NO: 13), showing detection of the peptide in lanes 1 and 3. Key: Lane 1, WT peptide only. Lane 2, B-var peptide only. Lane 3, WT peptide+normal plasma. Lane 4, B-var peptide+normal plasma. Lane 5, normal plasma only. Results show that normal plasma acquires Ciz1 b-variant signal at .about.80 kDa upon addition of b-var peptide, but not a-var peptide. e) Similar results were obtained using short b-variant peptide (DEEEIEVRSRDIS--SEQ ID NO: 2), when combined with either cancer or non-cancer plasma. Western blot shows results with anti-Ciz1 b-variant monoclonal antibody (left) or anti-Ciz1 b-variant polyclonal antibody 043 (right). Key: Lane 1, B-var peptide only. Lane 2, B-var peptide+normal plasma. Lane 3, B-var peptide+lung cancer plasma. Lane 4, Normal plasma alone. Lane 5, Lung cancer plasma alone. Note that mobility of new signal is similar to endogenous signal in cancer patient plasma. F) Western blot showing titration of short peptide (DEEEIEVRSRDIS--SEQ ID NO: 2) into cancer patient plasma, detected with anti-Ciz1 b-variant monoclonal antibody (upper) or anti-Ciz1 b-variant polyclonal antibody 043 (lower). Graph shows quantification of results by densitometry, with signal in normal plasma (N) set at 1. Results show that carrier protein is not limiting up to 4 nmol peptide/0.5 ul plasma. Overall, results show that endogenous b-var65 species, detected by anti Ciz1 b-variant antibodies, is likely not one single 65 kDa Ciz1 b-variant species, but a stable composite of Ciz1 b-variant fragment and carrier protein with MW close to 65 kDa.

[0046] FIG. 4--Isolation using a two-dimensional gel approach shows that the carrier protein is Fibrinogen. a) Western blot of cancer (C) and non-cancer (N) plasma samples after incubation in 2% SDS sample buffer with and without 200 mM b-mercaptoethanol. In the presence of reducing agent, a cancer-specific signal at .about.65 kDa is produced with anti-b variant antibodies, while in the absence of reducing agent cancer-specific signal is retarded to .about.340 kDa. b) First dimension gel (without reducing agent) is used to isolate Ciz1 b-variant epitope-containing .about.340 kDa band. c) Band is further resolved after incubation in reducing agent to reveal constitutive polypeptides and migration of Ciz1 b-variant epitope with a .about.70 kDa component. The band was excised for mass spectrometry. d) MASCOT assigned one significant identity based on two separate peptide masses after trypsin digest. Identity: Fibrinogen alpha chain.

[0047] FIG. 5--Reconstitution of Ciz1 b-variant epitope from purified fibrinogen and synthetic peptides. a) Silver stained gel (left) showing 6 nmols of purified fibrinogen complex (Sigma Cat. F3879), after electrophoresis in the absence of reducing agent (in 2% SDS loading buffer). Peptides are included in the experiment (100 pmols/lane) but do not stain well with silver due to their amino-acid content. Western blots of parallel gels are shown on the right, probed with two anti-b variant antibodies. L, Long Ciz1 b-variant peptide EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVRSRDISREEWKGSETYSPNTAYGV DFLV (SEQ ID NO: 12). S, Short Ciz1 b-variant peptide DEEEIEVRSRDIS (SEQ ID NO: 2). b) Similar experiment comparing a range of Ciz1 b-variant and a-variant peptides for their ability to form epitope that is reactive to the same antibodies, when in complex with fibrinogen. Key: 1, no additions. 2, Long Ciz1 b-variant peptide EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVRSRDISREEWKGSETYSPNTAYGV DFLV (SEQ ID NO: 12). 3, WT long peptide EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQRSRDISREEWKGSETYS PNTAYGVDFLV (SEQ ID NO: 13). 4, no additions. 5, Short Ciz1 b-variant DEEEIEVRSRDIS (SEQ ID NO: 2). 6, C-DEE.gamma.IEVRSRDIS-coNH2 (SEQ ID NO: 14). 7, C-DE.gamma.EIEVRSRDIS-coNH2 (SEQ ID NO: 23). 8, C-D.gamma..gamma..gamma.I.gamma.VRSRDIS-coNH2 (SEQ ID NO: 15).

[0048] FIG. 6--Table 1: Ciz1 b-variant peptides comprising an exon 14b/exon 15 junction (specified by exclusion of VEEELCKQ--SEQ ID NO: 10) from NCBI Reference Sequence: NM_001131016.1.

[0049] FIG. 7--Exon junction specific antibodies detect CIZ1b in lung cancer patient plasma. A) Map of CIZ1 translated exons showing alternative splicing of exon 14 to yield 14b (CIZ1b) by exclusion of the indicated 8 amino-acids (positions refer to NCBI Reference Sequence: NM_012127.2). Also shown are the location of epitopes detected with antibodies used in B. B) Western blot of representative plasma samples from a patient with NSCLC (LC) and normal control (N) after denaturation for SDS-PAGE, showing CIZ1b band at 65-70 kDa in LC (red arrow, marked "*") detected by CIZ1b antibodies 2B and 043, and a `generic` CIZ1 antibody-reactive band at 55 kDa in both N and LC, detected via epitopes in exon 8 and exon 17. Also indicated is fibrinogen alpha chain. C) Comparison of CIZ1b levels in paired plasma (P) and serum (S) samples from four individuals analysed with CIZ1b antibody 2B. Histogram shows quantified band intensities for the 65-70 kDa and 55 kDa entities, derived from triplicate samples, with standard deviation. Note that serum lacks the 65-70 kDa CIZ1b band. D) Model showing the simplest interpretation of the data in B, though extensive alternative splicing and likely secondary modification mean that the exact identity of the 55 kDa entity in plasma is unverified. E) Receiver operating characteristic (ROC) curves showing area under the curve (AUC) values for 2B and 043 western blot results on lung cancer test set A. Dot plot shows correlation between the two date sets (LC samples are orange). Thresholds (black dotted lines) are set at the mean of non-cancer samples in the set, plus one SD. These yield sensitivity/specificity estimates for this set of 20 lung cancer and 20 non-cancer samples of: 2B, 85/67.5; 043, 90/77.5. Using an arbitrary threshold specified by both antibodies these are 90/87.5.

[0050] FIG. 8--Effect of denaturation on CIZ1b epitope. A) Left, Coomassie blue stained gel of a representative lung cancer (C) and normal (N) plasma sample (2 ul), separated under fully native conditions (in the absence of SDS or reducing agent). m indicates marker lanes. Middle, parallel gel after transfer to nitrocellulose stained with Ponceau S. Right, the same membrane probed with CIZ1b antibody 043. Lower panel shows the same two samples (red arrows) separated by denaturing SDS-PAGE, also probed with 043. B) Native gel first dimension was soaked in 4.times.SDS-PAGE loading buffer for 30 minutes without heating, and further separated by size (second dimension). Western blot reveals one band at 55 kDa that is reactive with antibody 2B in the non-cancer sample, and two bands (55 and 70 kDa) in the cancer sample. Two additional cancer plasma samples, treated in the same way are shown below. C) Migration of 043-reactive bands in a representative cancer (C) and non-cancer (N) plasma sample through a non-denaturing gel, after prior incubation at the indicated temperatures, in the presence of 2% SDS, with and without reducing agent (200 mM .beta.-mercaptoethanol, .beta.ME) as indicated. Note the shift of cancer-specific band (red box) from relative mobility of approximately 340 kDa in the absence of reducing agent, to .about.70 kDa in the presence of reducing agent (accompanied by complete loss of the `generic` band that was detected in all samples in the absence of reducing agent). D) Plasma from a lung cancer patient showing 043-reactive band after incubation with 1% SDS at 37.degree. C. for 30 mins, with the indicated concentrations of DTT, or a 10-fold excess of .beta.ME. The reactive band is indicated as it shifts from 340 kDa to 70 kDa, and is then lost under maximally reducing conditions. The behaviour of fibrinogen in the same samples is shown for comparison, detected with antibody F8512. E) Synthetic CIZ1b epitope generated by combining CIZ1b peptide (b66, Table 2) with normal (non-cancer) plasma (see FIG. 10), behaves similarly to endogenous epitope, dissociating from within a high molecular weight complex, to a .about.70 kDa species, and then disappearing under maximally reducing conditions. Fibrinogen is detected with antibody AF4786. .beta.ME concentrations refer to multiples of the standard concentration used in SDS-PAGE of 200 mM.

[0051] FIG. 9--Deconstruction of CIZ1b biomarker and immunoassay design A) Schematic of results shown in FIG. 8, illustrating the complexity of the native complex in which CIZ1b epitope (red bar, marked "*") resides in plasma, and the disrupting effect of detergent and reducing agents. Under native conditions CIZ1b is part of a complex in excess of 720 kDa, most likely encompassed within lipid vesicles. SDS shifts the epitope to 340 kDa, and reducing agents shift it further to the mobility typically observed in standard SDS-PAGE gels (65-70 kDa). In the presence of excess reducing agent the western blot epitope is lost for both 2B and 043 CIZ1b antibodies. B) Schematic of sandwich ELISA format based on information summarised in A.

[0052] FIG. 10--Reconstitution of CIZ1b biomarker from purified components A) Two independent lung cancer patient plasmas were separated after incubation with 1% SDS (no reducing agent), in order to isolate the 340 kDa band from stained gels (left). Band identity was verified by ponceau S stain followed by Western blot with anti-CIZ1b antibody 043 of a parallel gel (right). B) Gel slices were soaked in 2% SDS-PAGE loading buffer (with 200 mM .beta.ME) and separated through a denaturing gel to recover the 043-reactive species at 70 kDa. Note that sample loaded as a gel slice is slightly retardation compared to markers which are loaded in solution. Coomassie blue staining revealed 5 dominant bands including one at 70 kDa, which was isolated and digested with either trypsin (cancer plasma 1, C1) or AspN (cancer plasma 2, C2). C) Western blot of normal human plasma (non-cancer, N) showing reconstitution of CIZ1b epitope via complex formation between a carrier protein in plasma and synthetic CIZ1b peptides of the indicated lengths, but not equivalent CIZ1a peptide (Table 2). Note that free peptides migrate in reducing SDS-PAGE with a relative mobility 3 times expected (.about.21 kDa instead of 7.6 kDa for b66, .about.5 kDa instead of 1.6 for b13). None are recognized by CIZ1b antibodies in western blot unless complexed with carrier protein. For CIZ1b66 peptide a new reactive species is created at .about.80 kDa, while CIZ1b13 peptide increases antigenicity at the same mobility as the endogenous epitope in lung cancer plasmas (C, lane 1). D) Western blot of non-reducing SDS-PAGE gel showing purified fibrinogen (6 nmols) in all lanes (upper), with and without prior incubation with 100 pmols of the indicated peptides (Table 2), probed with CIZ1b antibodies as indicated. Under non-reducing conditions fibrinogen migrates with apparent molecular weight of .about.340 kDa and this co-migrates with CIZ1b signal. E) Direct ELISA showing mean A450 nm (triplicate analysis with SEM) generated by CIZ1b antibodies 2B or 043 as indicated, using molar equivalents of preformed peptide/fibrinogen complex as analyte. ** T test p<0.05.

[0053] FIG. 11--Immunoassay validation using lung cancer plasma and controls (n=39 non-cancer, 13 lung cancer). A) CIZ1b western blot with antibody 043. B) Sandwich ELISA format for CIZ1b antigen in plasma, using 043 capture antibody and anti-fibrinogen detector antibody. C) Quantitative detection of fibrinogen in the same samples using paired fibrinogen antibodies D) Substitution of anti-human IgG for anti-fibrinogen in a sandwich format similar to that shown in B. E) Detection of IgG in plasma by direct ELISA. F) Normalization of the data in C against the data in G. In all cases, receiver operating characteristic curves (ROC) indicate the relationship between true positive and false positive fraction (black points) and 95% confidence interval of the fitted ROC curve (grey points), and area under the curve (AUC) values in bold. Box and whisker plots display minimum and maximum, lower, median, and upper quartile, and outliers.

DETAILED DESCRIPTION OF THE INVENTION

Ciz1

[0054] Cip1-interacting zinc finger protein (Ciz1) is a protein that in humans is encoded by the CIZ1 gene.

[0055] Ciz1 promotes initiation of mammalian DNA replication, where it helps coordinate the sequential functions of cyclin E- and A-dependent protein kinases (Coverley et al; J Cell Sci. 2005; 118(Pt 1):101-112). It interacts directly with cyclins E and A, CDK2, and cyclin-dependent kinase inhibitor p21 and also plays an indirect role in DNA replication by modulating the expression of genes, including cyclin D, that influence cell proliferation (den Hollander et al; Cancer Res. 2006; 66(22):11021-11029). Ciz1 is often attached to the salt- and nuclease-resistant protein component of the nucleus referred to as the "nuclear matrix" and resides within foci that partially colocalize with sites of DNA replication (Ainscough; J Cell Sci. 2007; 120(Pt 1):115-124), implicating Ciz1 in the spatial organization of DNA replication.

[0056] Various splice variants of Ciz1 are known in the art. For example, as described in WO 2004/051269 and Rahman et al. (BMC Cancer; 2010; 10:482).

[0057] The alternative splicing of Ciz1 exon 14 to generate a Ciz1 b-variant isoform has previously been demonstrated in various cancers ((WO 2012/017208) and (Higgins et al.; PNAS; Nov 6; 109(45):E3128-35)).

[0058] As described herein, a Ciz1 b-variant isoform is derived from a Ciz1 mRNA transcript which comprises a variant of exon 14 referred to herein as exon 14b (SEQ ID NO: 3). Ciz1 exon 14b lacks 24 nucleotides at the 3' end as compared to full length exon 14, referred to as exon 14a (SEQ ID NO: 4). Ciz1 transcripts expressing exon 14b rather than exon 14a (a-variant) are referred to herein as Ciz1 b-variant, CIZ1b or simply b-variant. The corresponding amino acid sequences of Ciz1 exon 14b and 14a are shown as SEQ ID NO: 5 (LKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIE) and SEQ ID NO: 6 (LKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQ) respectively (see FIG. 2).

[0059] The sequence spanning a splice junction of exon 14b and exon 15 is therefore different to the sequence spanning a splice junction of exon 14a and exon 15. In particular, the junction of exon 14b and exon 15 lacks the sequence VEEELCKQ (SEQ ID NO: 10) which is present at the junction between exon 14a and exon 15 in Ciz1 a-variant proteins.

[0060] The present inventors have determined that Ciz1 b-variant peptides exist in a complex with fibrinogen. In particular, it has been shown that Ciz1 b-variant peptides which span an exon 14b/exon 15 junction are able to bind to fibrinogen. In contrast, Ciz1 a-variant peptides are not able to bind to fibrinogen.

[0061] Accordingly, as described herein, a Ciz1 b-variant peptide refers to a peptide which can be derived from a Ciz1 b-variant protein but not a Ciz1 a-variant protein. In other words, a Ciz1 b-variant peptide refers to a portion of a Ciz1 b-variant protein which is derived from exons 14b and exon 15 of a Ciz1 b-variant protein and therefore lacks the sequence VEEELCKQ (SEQ ID NO: 10) at the splice junction.

[0062] In particular, a Ciz1 b-variant peptide comprises an exon 14b/exon 15 splice junction. In other words, a ciz1 b-variant peptide comprises amino acid sequences derived from Ciz1 exon 14b (SEQ ID NO: 5) and Ciz1 exon 15 (SEQ ID NO: 7) and comprises the sequence EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

TABLE-US-00001 SEQ ID NO: 11 EIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVRSRDISREEWK GSETYSPNTAYGVDFLVP

[0063] Notably, Ciz1 b-variant peptides do not contain amino acids which are specific to Ciz1 a-variant proteins and therefore do not comprise the sequence VEEELCKQ (SEQ ID NO: 10).

[0064] As such, a Ciz1 b-variant peptide may be the Ciz1 b-variant peptide shown as SEQ ID NO: 11 or a fragment thereof which comprises EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

[0065] Suitably, the Ciz1 b-variant peptide may comprise at least 3, at least 5, at least 10, at least 20, at least 30, at least 40, at least 50 or at least 60 contiguous amino acids of SEQ ID NO: 11 and comprise EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

[0066] Suitably, the Ciz1 b-variant peptide may comprise or consist of from 3 to 60, 5 to 60, 5 to 50, 10 to 50, 10 to 40, 10 to 30, 15 to 30 or 10 to 20 contiguous amino acids of SEQ ID NO: 11 and comprise EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

[0067] Suitably, the Ciz1 b-variant peptide may comprise or consist of 10 to 20 contiguous amino acids of SEQ ID NO: 11 and comprise EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

[0068] Suitably, a Ciz1 b-variant peptide may be a peptide shown in Table 1 (see FIG. 6).

Fibrinogen

[0069] In one aspect, the present invention relates to the use of a fibrinogen capture agent or a fibrinogen detection agent in an assay to detect Ciz1 b-variant.

[0070] In one aspect, the present invention relates to the use of a fibrinogen binding agent in an assay to detect Ciz1 b-variant.

[0071] The fibrinogen binding agent may be an antibody or a fragment thereof, non-protein scaffold or aptamer which specifically binds fibrinogen.

[0072] In particular, the present invention provides the use of an antibody or a fragment thereof, which binds fibrinogen in an assay to detect Ciz1 b-variant.

[0073] Fibrinogen is involved in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing and neoplasia.

[0074] Fibrinogen molecules are elongated 45 nm structures that consist of two outer D domains, each connected by a coiled-coil segment to a central E domain. The molecule is comprised of two sets of three polypeptide chains termed .alpha., .beta., and .gamma., which are joined together in the N-terminal E domain by five symmetrical disulfide bridges. Non-symmetrical disulfide bridges form a `disulfide ring` in this region (Mosesson; 2005; Journal of Thrombosis and Haemostasis; 3(8); 1894-1940).

[0075] Polymerisation of fibrinogen molecules results in the formation of an insoluble fibrin matrix. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from .alpha. and .beta. chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between .gamma. chains (stronger) and between .alpha. chains (weaker) of different monomers.

[0076] The .alpha.-chain consists of 610, the .beta.-chain 461, and the major .gamma.-chain form, .gamma.A, 411 residues. Each fibrinogen .alpha.-chain contains an N-terminal fibrinopeptide A (FPA) sequence, cleavage of which by thrombin initiates fibrin assembly by exposing a polymerization site termed EA. One portion of EA is at the N-terminus of the fibrin .alpha.-chain comprising residues 17-20 gly-pro-arg-val (GPRV), and another portion is located in the fibrin .beta.-chain between residues 15 and 42. Each EA-site combines with a constitutive complementary-binding pocket (Da) in the D domain of neighbouring molecules that is located between .gamma.337 and .gamma.379. The initial EA:Da associations cause fibrin molecules to align in a staggered overlapping end-to-middle domain arrangement to form double-stranded twisting fibrils. Fibrils also undergo lateral associations to create multi-stranded fibres (Mosesson; as above).

[0077] An example fibrinogen .alpha. protein is the human fibrinogen .alpha. protein having the UniProtKB accession number P02671. This exemplified sequence is 866 amino acids in length of which amino acids 1 to 19 form a signal peptide.

[0078] An example fibrinogen .beta. protein is the human fibrinogen .beta. protein having the UniProtKB accession number P02675. This exemplified sequence is 491 amino acids in length of which amino acids 1 to 30 form a signal peptide.

[0079] An example fibrinogen .gamma. protein is the human fibrinogen .gamma. protein having the UniProtKB accession number P02679. This exemplified sequence is 453 amino acids in length of which amino acids 1 to 26 form a signal peptide.

[0080] The term `fibrinogen` may refer to a complex comprising two .alpha. chains, two .beta. chains and two .gamma. chains or a sub-complex thereof (e.g. which does not include all the chains of the full fibrinogen complex).

[0081] The present inventors have determined that Ciz1 b-variant peptides are capable of binding to the fibrinogen .alpha. chain. As such, in particular embodiments the present assays and methods may involve the capture or detection of the fibrinogen .alpha. chain. For example the present assays and methods may involve the detection of fibrinogen (e.g. fibrinogen .alpha. chain) following the capture of Ciz1 b-variant in the fibrinogen/Ciz1 b-variant complex.

[0082] A `fibrinogen/Ciz1 b-variant complex` as referred to herein may comprise other peptides and/or proteins aside from the fibrinogen and/or Ciz1 b-variant peptide.

[0083] As used herein, a capture agent refers to an agent which is used to isolate (i.e. enrich) the fibrinogen/Ciz1 b-variant complex from a sample. For example, the sample may be a sample which has been isolated from a subject. In particular, the sample may be a blood sample (e.g. a plasma sample) which has been isolated from a subject.

[0084] A `fibrinogen capture agent` refers to an entity which is capable of binding to a fibrinogen/Ciz1 b-variant complex. Preferably, a `fibrinogen capture agent` is an entity which is capable of specifically binding to fibrinogen and is used to isolate (i.e. enrich) the fibrinogen/Ciz1 b-variant complex from a sample. Such specific binding may enable the isolation/enrichment of fibrinogen from a sample. In particular embodiments, the fibrinogen capture agent may be capable of specifically binding to a fibrinogen .alpha. chain.

[0085] The fibrinogen capture agent may be an antibody or a fragment thereof, non-protein scaffold, aptamer or Ciz1 b-variant peptide which specifically binds fibrinogen.

[0086] As used herein, a detection agent refers to an agent which is used to bind the fibrinogen/Ciz1 b-variant complex after it has been isolated (i.e. enriched) from a sample using a capture agent. As such, the detection agent is typically used after a capture step to determine the presence of the isolated (i.e. enriched) fibrinogen/Ciz1 b-variant complex.

[0087] A `fibrinogen detection agent` refers to an entity which is capable of binding to a fibrinogen. Preferably, a `fibrinogen detection agent` is an entity which is capable of specifically binding to fibrinogen. Such specific binding enables the detection of fibrinogen following the capture of Ciz1 b-variant in the fibrinogen/Ciz1 b-variant complex. In particular embodiments, the fibrinogen capture agent or fibrinogen detection agent may be capable of specifically binding to a fibrinogen .alpha. chain.

[0088] The fibrinogen detection agent may be an antibody or a fragment thereof, non-protein scaffold, or aptamer which specifically binds fibrinogen.

[0089] The fibrinogen detection agent may be labelled with an entity which enables it to be detected in an assay as described herein. For example, the fibrinogen detection agent may be labelled with a fluorescent entity or an enzyme-substrate label as described herein.

Antibody

[0090] An antibody or a fragment thereof, refers to any portion of an antibody which retains the ability to bind to the same antigen target as the parental antibody--e.g. a fibrinogen antibody or a fragment thereof is able to bind to fibrinogen.

[0091] Fibrinogen antibodies are known in the art. For example, sheep anti-fibrinogen pAb (AF4786 R&D systems), ab58207 (Abcam); Anti-Fibrinogen, clone 85D4 (Cat. No. F9902; Sigma Aldrich); and Fibrinogen Antibody (MFB-HB) (Cat. No. MA1-35371; Life Technologies).

[0092] Fibrinogen .alpha. chain antibodies are also known in the art. For example, EPR2918 (ab108616; Abcam); Fibrinogen Antibody (5C5) (LF-MA0108; Pierce); and EPR2919 (TA307697; Origene).

[0093] The present invention also encompasses methods which comprise the step of detecting Ciz1 b-variant or capturing Ciz1 b-variant/fibrinogen complex by contacting the Ciz1 b-variant with an antibody or fragment thereof that binds to the Ciz1 b-variant. An antibody which specifically binds a Ciz1 b-variant peptide may be generated as previously described for antibody 2B (Higgins et al; 2012; PNAS; Nov 6; 109(45):E3128-35).

[0094] The antibody may be a chimeric antibody. Chimeric antibodies may be produced by transplanting antibody variable domains from one species (for example, a mouse) onto antibody constant domains from another species (for example a human).

[0095] The antibody may be a full-length, classical antibody. For example the antibody may be an IgG, IgM or IgA molecule.

[0096] The antibody may be a functional antibody fragment. Specific antibody fragments include, but are not limited to, (i) the Fab fragment consisting of VL, VH, CL and CH1 domains, (ii) the Fd fragment consisting of the VH and CH1 domains, (iii) the Fv fragment consisting of the VL and VH domains of a single antibody, (iv) the dAb fragment, which consists of a single variable domain, (v) isolated CDR regions, (vi) F(ab')2 fragments, a bivalent fragment comprising two linked Fab fragments (vii) single chain Fv molecules (scFv), wherein a VH domain and a VL domain are linked by a peptide linker which allows the two domains to associate to form an antigen binding site, (viii) bispecific single chain Fv dimers, and (ix) "diabodies" or "triabodies", multivalent or multispecific fragments constructed by gene fusion. The antibody fragments may be modified. For example, the molecules may be stabilized by the incorporation of disulphide bridges linking the VH and VL domains.

[0097] The antibody described herein may be a multispecific antibody, and notably a bispecific antibody, also sometimes referred to as "diabodies". These are antibodies that bind to two (or more) different antigens. Diabodies can be manufactured in a variety of ways known in the art, e.g., prepared chemically or from hybrid hybridomas. The antibody may be a minibody. Minibodies are minimized antibody-like proteins comprising a scFv joined to a CH3 domain. In some cases, the scFv can be joined to the Fc region, and may include some or all of the hinge region.

[0098] The antibody may be a domain antibody (also referred to as a single-domain antibody or nanobody). This is an antibody fragment containing a single monomeric single variable antibody domain. Examples of single-domain antibodies include, but are not limited to, VHH fragments originally found in camelids and VNAR fragments originally found in cartilaginous fishes. Single-domain antibodies may also be generated by splitting the dimeric variable domains from common IgG molecules into monomers.

[0099] The antibody may be a synthetic antibody (also referred to as an antibody mimetic). Antibody mimetics include, but are not limited to, Affibodies, DARPins, Anticalins, Avimers, Versabodies and Duocalins.

Aptamers

[0100] Aptamers that specifically recognize fibrinogen or Ciz1 b-variant may be synthesized using standard nucleic acid synthesis techniques or selected from a large random sequence pool, for example using the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technique.

[0101] Aptamers can be single strand DNA or RNA sequences that fold in a unique 3D structure having a combination of stems, loops, quadruplexes, pseudoknots, bulges, or hairpins. The molecular recognition of aptamers results from intermolecular interactions such as the stacking of aromatic rings, electrostatic and van der Waals interactions, or hydrogen bonding with a target compound. In addition, the specific interaction between an aptamer and its target is complemented through an induced fit mechanism, which requires the aptamer to adopt a unique folded structure to its target. Aptamers can be modified to be linked with labeling molecules such as dyes, or immobilized on the surface of beads or substrates for different applications.

[0102] Aptamers may be paired with nanotechnology, microarray, microfluidics, mass spectrometry and other technologies for quantification in a given sample.

[0103] Typically, a fibrinogen capture agent or a Ciz1 b-variant capture agent will be immobilised on a support, such as an array, or be captured on a solid support, such as beads. A sample to be tested is then incubated with the support comprising the capture agent such that Ciz1 b-variant/fibrinogen complex can be isolated/enriched from the sample. Supports (eg. solid supports) can be made of a variety of materials--such as glass, silica, plastic, nylon or nitrocellulose. When attached to a solid support it is preferably rigid and have a planar surface.

[0104] The fibrinogen capture agent or Ciz1 b-variant capture agent may comprise a moiety that can be captured on a solid surface, such as a biotin moiety which can be captured by streptavidin beads. In such embodiments, capture to a support can occur follow incubation of the capture agent with a sample.

Detecting Ciz1 b-Variant or Capturing a Ciz1 b-Variant

[0105] Suitably, the Ciz1 b-variant may be a Ciz1 b-variant peptide as described herein.

[0106] A Ciz1 b-variant may be detected using a variety of suitable methods and techniques known in the art.

[0107] The method may comprise the following steps: a) capturing a fibrinogen/Ciz1 b-variant complex using a fibrinogen capture agent; and b) detecting Ciz1 b-variant using a Ciz1 b-variant detection agent.

[0108] The method may comprise the following steps: a) capturing a fibrinogen/Ciz1 b-variant complex using a Ciz1 b-variant capture agent; and b) detecting fibrinogen using a fibrinogen detection agent.

[0109] As used herein, a `Ciz1 b-variant capture agent` refers to an entity which is capable of binding to a Ciz1 b-variant and is used to isolate (i.e. enrich) the fibrinogen/Ciz1 b-variant complex from a sample. Preferably, a `Ciz1 b-variant capture agent` is an entity which is capable of specifically binding to Ciz1 b-variant. Such specific binding enables the isolation/enrichment of the fibrinogen/Ciz1 b-variant complex from a sample.

[0110] The Ciz1 b-variant capture agent may be an antibody or a fragment thereof, non-protein scaffold, aptamer or Ciz1 b-variant peptide which specifically binds fibrinogen.

[0111] In particular embodiments, a Ciz1 b-variant/fibrinogen complex may be captured using an antibody or fragment thereof that binds to the Ciz1 b-variant peptide. An antibody which specifically binds a Ciz1 b-variant peptide may be generated as previously described for antibody 2B (Higgins et al; 2012; PNAS; Nov 6; 109(45):E3128-35).

[0112] A `Ciz1 b-variant detection agent` refers to an entity which is capable of binding to a Ciz1 b-variant and is used to bind the fibrinogen/Ciz1 b-variant complex after it has been isolated (i.e. enriched) from a sample using a capture agent. Preferably, a `Ciz1 b-variant detection agent` is an entity which is capable of specifically binding to Ciz1 b-variant. Such specific binding enables the detection of Ciz1 b-variant following the capture of the fibrinogen/Ciz1 b-variant complex.

[0113] The Ciz1 b-variant detection agent may be an antibody or a fragment thereof, non-protein scaffold, or aptamer which specifically binds Ciz1 b-variant.

[0114] The Ciz1 b-variant detection agent may be labelled with an entity which enables it to be detected in an assay as described herein. For example, the Ciz1 b-variant detection agent may be labelled with a fluorescent entity or an enzyme-substrate label as described herein.

[0115] For example, methods for detecting Ciz1 b-variant may employ antibody-based arrays, enzyme linked immunosorbent assays (ELISA), non-antibody protein scaffolds, radioimmuno-assay (RIA), western blotting, aptamers or mass spectrometry.

[0116] An ELISA may be performed according to general methods which are known in the art. For example, the ELISA may be a sandwich or competitive ELISA.

[0117] A sandwich ELISA may comprise the following steps:

[0118] a surface (Le. a microtitre plate well) is prepared to which a known quantity of capture agent is bound (e.g. a Ciz1 b-variant capture agent or a fibrinogen capture agent);

[0119] any nonspecific binding sites on the surface are blocked;

[0120] the sample comprising the Ciz1 b-variant is applied to the plate;

[0121] the plate is washed to remove unbound antigen;

[0122] a primary antibody which is capable of specifically binding the fibrinogen or Ciz1 b-variant is added, and binds to antigen;

[0123] an enzyme-linked secondary antibody is applied as a detection antibody that bind specifically to the antibody Fc region;

[0124] the plate is washed to remove the unbound antibody-enzyme conjugates, before a chemical is added to be converted by the enzyme into a colour or fluorescent or electrochemical signal;

[0125] the absorbency or fluorescence or electrochemical signal of the plate wells is measured to determine the presence and quantity of antigen.

[0126] In particular embodiments, the present methods comprise the step of capturing a fibrinogen/Ciz1 b-variant complex using a fibrinogen capture agent or a Ciz1 b-variant capture agent as described herein.

[0127] In one embodiment the present methods comprise a sandwich ELISA which comprises the steps of capturing a fibrinogen/Ciz1 b-variant complex using a Ciz1 b-variant capture agent as described herein and detecting the fibrinogen/Ciz1 b-variant complex using a fibrinogen detection agent as described herein.

[0128] A competitive ELISA may comprise the following steps:

[0129] a labelled antibody which specifically binds the Ciz1 b-variant is incubated in the presence of a sample comprising the Ciz1 b-variant;

[0130] the bound antibody/antigen complexes are then added to an antigen-coated well;

[0131] the plate is washed, so unbound antibody is removed;

[0132] a secondary antibody, specific to the primary antibody, and coupled to an enzyme is added;

[0133] a substrate for the enzyme is added, and the reaction of the enzyme with its substrate elicits a chromogenic or fluorescent signal;

[0134] the reaction is stopped to prevent eventual saturation of the signal.

[0135] Various enzyme-substrate labels are available, e.g. as disclosed in U.S. Pat. No. 4,275,149. The enzyme generally catalyses a chemical alteration of the chromogenic substrate that can be detected. For example, the enzyme may catalyse a colour change in a substrate, or may alter the fluorescence or chemiluminescence of the substrate. Examples of enzymatic labels include peroxidase such as horseradish peroxidase (HRPO), alkaline phosphatase, beta-galactosidase, glucoamylase, lysozyme, saccharide oxidases (e.g., glucose oxidase, galactose oxidase, and glucose-6-phosphate dehydrogenase), heterocyclic oxidases (such as uricase and xanthine oxidase), lactoperoxidase, microperoxidase, and the like. Techniques for conjugating enzymes to antibodies are well known.

[0136] Detecting a Ciz1 b-variant peptide may comprise contacting said Ciz1 b-variant peptide with an antibody or fragment thereof that binds to the Ciz1 b-variant peptide. An antibody which specifically binds a Ciz1 b-variant peptide may be generated as previously described for antibody 2B (Higgins et al; 2012; PNAS; Nov 6; 109(45):E3128-35).

[0137] In some embodiments the b-variant specific antibody may bind to an epitope comprising the EVR sequence shown in positions 36 to 38 of SEQ ID NO: 11.

[0138] In some embodiments, the antibody specifically binds to an amino acid sequence comprising DEEEIEVRSRDIS (SEQ ID NO: 2) but does not specifically bind to an amino acid sequence comprising DEEEIEVEEELCKQVRSRDIS (SEQ ID NO: 9).

[0139] However, in some embodiments, the sequence bound by a b-variant specific antibody may be present in both Ciz1 exon 14a (SEQ ID NO: 6) and Ciz1 exon 14b (SEQ ID NO: 5). In such embodiments, the b-variant specific antibody may be unable to bind to Ciz1 a-variant because the presence of the VEEELCKQ sequence (SEQ ID NO: 10) prevents the antibody binding. In other embodiments, the antibodies may bind to sequences present in both Ciz1 exon 14a and Ciz1 exon 14b, because the sequences are presented in a b-variant specific conformation or structure.

[0140] In some embodiments, the b-variant specific antibody may bind to an epitope formed by a Ciz1 b-variant peptide/fibrinogen complex.

[0141] Without being bound by theory, the binding of Ciz1 b-variant to fibrinogen may expose epitopes which comprise amino acid sequences which are common between Ciz1 exon 14a (SEQ ID NO: 6) and Ciz1 exon 14b (SEQ ID NO: 5) in a conformation which is unique to the fibrinogen/Ciz1 b-variant. Such conformational epitopes will therefore not be present in Ciz1 a-variant.

Sample

[0142] In certain embodiments, the present invention utilises a sample isolated from a subject. This sample may be referred to as a `test sample`. Thus the present methods are typically practiced outside of the human or animal body, e.g. on a sample that was previously obtained from the subject to be tested.

[0143] The sample may be a blood, urine, saliva or bronchoalveolar lavage sample.

[0144] In a preferred embodiment the sample is a blood sample. Suitably, the blood sample may be a whole blood sample. Suitably, the blood sample may be a blood fraction, for example a plasma sample.

[0145] Techniques for collecting blood samples and separating blood fractions are well known in the art. For instance, vena blood samples can be collected from patients using a needle and deposited into plastic tubes. The collection tubes may, for example, contain anticoagulants, spray-coated silica, or a polymer gel for separation. Plasma can be separated by centrifugation at 1300 RCF for 10 min at room temperature and stored in small plastic tubes at -80.degree. C.

[0146] In a preferred embodiment the sample is a blood sample, in particular a plasma sample. In a preferred embodiment the blood sample is treated with anticoagulants (e.g. heparin) following collection.

Detergent

[0147] In one embodiment, the present methods may comprise treating the sample with a detergent in order to release the Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex.

[0148] Examples of detergent include, but are not limited to, sodium dodecyl sulfate (SDS) and polysorbate 20. For example, the sample may be treated with about 1 to 5%, preferably 1 to 2% SDS.

[0149] Suitably, the present methods may further comprise treating the sample with a reducing agent in order to further purify the Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex. Examples of suitable reducing agents include, but are not limited to, Dithiothreitol (DTT)--which may be used at a concentration of about 10 mM DTT, for example.

Exosomes

[0150] The present methods may comprise the step of releasing Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from the exosomal compartment of a sample. Suitably, the present methods may comprise the step of releasing Ciz1 b-variant peptides from the exosomal compartment of a sample.

[0151] Exosomes are nanometer-sized (30-100 nm) vesicles found in many biological fluids, such as urine, blood (in both plasma and serum), ascites, and cerebrospinal fluid. They originate as internal vesicles of multi-vesicular bodies (MVBs) in cells and were first described as products of circulating blood cells, such as erythrocytes and lymphocytes.

[0152] Exosomes are surrounded by a phospholipid membrane containing relatively high levels of cholesterol, sphingomyelin, and ceramide and containing detergent-resistant membrane domains (lipid rafts) (Mathivanan et al., 2010; J Proteomics 73:1907-1920).

[0153] Exosomes are characterized by the presence of proteins involved in membrane transport and fusion, such as Rab, GTPases, annexins, and flotillin, components of the endosomal sorting complex required for transport (ESCRT) complex such as Alix, tumor susceptibility gene 101 (TSG101), heat shock proteins (HSPs), integrins, and tetraspanins, including CD63, CD81, and CD82 (van der Pol et al.; 2012; 64(3); 676-705).

[0154] Releasing Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment refers to disrupting the structural integrity of the exosome such that Ciz1 b-variant epitopes which were previously concealed within the internal structure of the exosomes are exposed for binding.

[0155] Suitably, releasing Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment may refer to treating a sample with a detergent. Examples of detergent include, but are not limited to, sodium dodecyl sulfate (SDS) and polysorbate 20.

[0156] In one embodiment, the sample may be treated with a detergent at a concentration which is suitable to release Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment. For example, the sample may be treated with about 1 to 5%, preferably 1 to 2% SDS.

Exosome Enrichment

[0157] The present methods may involve enriching an exosomal fraction from a sample.

[0158] As used herein, enriching an exosomal fraction is synonymous to purifying or isolating an exosomal fraction.

[0159] Exosomes may be purified by methods known in the art such as ultracentrifugation (Pisitkun et al (2004) PNAS 101:13368-13373) or ultrafiltration (Cheruvanky et al (2007) Am. J. Physiol. Renal Physiol. 292:F1657-F1661). Methods are also known involving continuous flow electrophoresis and chromatography procedures which may precede centrifugation (Taylor and Gercel-Taylor (2005) Br J Cancer 92:305-311). Cross-flow ultrafiltration may also be used as part of the exosome purification method (Lamparski et al (2002) J Immunol. Methods 270:211-226).

[0160] Commercial kits for the isolation of exosomes are also available, for example the Total Exosome Isolation Kit provided by Invitrogen.

[0161] Exosomes can be isolated from a multitude of cell line and body fluids by combining differential centrifugation, membrane filtration, concentration, rate zonal centrifugation and immunocapture, exosomes (Simpson et al.; Proteomics, 8 (2008), pp. 4083-4099).

[0162] Exosomes can be detected and/or purified on the basis of their expression of exosomal markers such as tumour susceptibility gene (TSG101), aqua-porin.about.2 (AQP2), neuron-specific enolase (NES), annexin V, podocalyxin (PODXL) and CD9. For example, exosomes may be captured on to a microplate, for example by immunoaffinity capture.

[0163] Characterization of isolated exosomes is typically performed using electron microscopy, FACS, LC-MS/MS, Western blotting or ELISA (Simpson et al.; as above) and (van Niel et al; J Biochem (Tokyo), 140 (2006), pp. 13-21).

Cancer

[0164] In one aspect, the present invention relates to a method of diagnosing cancer in a subject.

[0165] As used herein, the term "cancer" or "cancerous" refers to cells having the capacity for autonomous growth, i.e., an abnormal state or condition characterized by rapidly proliferating cell growth. The term is meant to include all types of cancerous growths or oncogenic processes, metastatic tissues or malignantly transformed cells, tissues, or organs, irrespective of histopathologic type or stage of invasiveness. The term "cancer" includes malignancies of the various organ systems, such as those affecting, for example, lung, breast, thyroid, lymphoid, gastrointestinal, reproductive and genito-urinary tract, as well as adenocarcinomas which include malignancies such as most colon cancers, renal-cell carcinoma, prostate cancer and/or testicular tumours, non-small cell carcinoma of the lung, cancer of the small intestine and cancer of the esophagus.

[0166] Suitably, the cancer may be lung cancer, lymphoma, kidney cancer, breast cancer, liver cancer, bladder cancer, ovarian or thyroid cancer.

[0167] In one embodiment, the cancer is lung cancer. The lung cancer may be small cell lung cancer. The lung cancer may be non-small cell lung cancer.

Subject

[0168] The subject may be a human or animal subject. Preferably, the subject is a human.

[0169] The subject may have or be at risk of cancer, as described herein. `At risk of cancer` refers to a subject who is not showing any symptoms of the disease. The subject may have a predisposition for, or be thought to be at risk of developing, cancer.

Treating

[0170] In one aspect the present invention relates to a method for treating a subject with cancer comprising administering to the subject a cancer therapeutic; wherein the subject has been identified as having cancer by a method of the present invention.

[0171] In another aspect the present invention provides an anticancer drug for use in treating cancer wherein the subject has been identified as having cancer by a method of the present invention. In a further aspect, the present invention relates to an anticancer lung cancer drug for use in treating lung cancer wherein the subject has been identified as having lung cancer by a method of the present invention.

[0172] `Treating` or `to treat` refers to the therapeutic use of a cancer therapeutic or anticancer agent. Herein the cancer therapeutic or anticancer agent may be administered to a subject having an existing disease or condition in order to lessen, reduce or improve at least one symptom associated with the disease and/or to slow down, reduce or block the progression of the disease.

Anticancer Drug

[0173] An `anticancer drug` is synonymous with a cancer therapeutic and refers to an entity which may be used to treat cancer.

[0174] The anti-cancer drug may be a cytokine or haematopoietic factor including, but not limited to, IL-1, IL-2, IL-4, IL-5, IL-13, IL-6, CSF-1, M-CSF, GM-CSF, IFN.alpha., IFN.beta., IFN.gamma., IL-10, IL-12, VEGF, bone morphogenic proteins, FGFs, TNF and TGF.beta..

[0175] The anticancer drug may be a chemotherapeutic agent, which may be a cytotoxic drug. A chemotherapeutic agent contemplated includes, without limitation, alkylating agents, nitrosoureas, ethylenimines/methylmelamine, alkyl sulfonates, antimetabolites, pyrimidine analogs, epipodophylotoxins, enzymes such as L-asparaginase; biological response modifiers such as IFN.alpha., IL-2, G-CSF and GM-CSF; platinium coordination complexes such as cisplatin and carboplatin, anthracenediones, substituted urea such as hydroxyurea, methylhydrazine derivatives including N-methylhydrazine (MIH) and procarbazine, adrenocortical suppressants such as mitotane (o,p'-DDD) and aminoglutethimide; hormones and antagonists including adrenocorticosteroid antagonists such as prednisone and equivalents, dexamethasone and aminoglutethimide; progestin such as hydroxyprogesterone caproate, medroxyprogesterone acetate and megestrol acetate; estrogen such as diethylstilbestrol and ethinyl estradiol equivalents; antiestrogen such as tamoxifen; androgens including testosterone propionate and fluoxymesterone/equivalents; antiandrogens such as flutamide, gonadotropin-releasing hormone analogs and leuprolide; and non-steroidal antiandrogens such as flutamide.

[0176] The anticancer drug may be a siRNA or shRNA.

[0177] Suitably, the anticancer drug may be an anticancer lung cancer drug. An anticancer lung cancer drug refers to an entity which may be used to treat lung cancer.

Kit

[0178] In one aspect, the present invention provides a kit comprising an agent which specifically binds fibrinogen and an agent which specifically binds Ciz1 b-variant.

[0179] The agent which specifically binds fibrinogen may be a fibrinogen capture agent as described herein.

[0180] The agent which specifically binds Ciz1 b-variant may be a Ciz1 b-variant detection agent as described herein.

[0181] The terms "comprising", "comprises" and "comprised of" as used herein are synonymous with "including", "includes" or "containing", "contains", and are inclusive or open-ended and do not exclude additional, non-recited members, elements or method steps. The terms "comprising", "comprises" and "comprised of" also include the term "consisting of".

[0182] The invention will now be further described by way of Examples, which are meant to serve to assist one of ordinary skill in the art in carrying out the invention and are not intended in any way to limit the scope of the invention.

EXAMPLES

Example 1

Enrichment of Ciz1 b-Variant in an Exosomal Fraction From a Blood Sample

[0183] The antibody 043 was generated and validated as described previously for antibody 2B (Higgins et al; PNAS 2012; Nov 6; 109(45):E3128-35)). The antibody was capable of detecting of Ciz-1 b-variant polypeptide by western blot in plasma from lung cancer patients (see FIG. 1a).

[0184] Plasma from lung cancer patients was separated into the exosomal compartment and soluble compartment using Invitrogen Total Exosome Isolation Kit (Catalog Number 4484450) used as recommended by the manufacturer. Fractions were separated by SDS-PAGE and probed with 043 antibody or with `generic` CIZ1 antibodies that recognize an epitope elsewhere in the protein (data shown in FIG. 1b is generated with NB100-74624 (Nov4), Novus Biologicals).

[0185] The Ciz1 b-variant epitope containing species migrated with relative mobility of .about.70 kDa. The Ciz1 b-variant epitope containing species co-fractionated with the exosomal fraction in lung cancer patients (see FIG. 1b, red and blue arrows indicate lanes showing different partitioning of Ciz1 isoforms). In rare patients, the Ciz1 b-variant epitope containing species partly partitions with the non-exosomal fraction (type 2, FIG. 1c). Plasma from these patients gave a positive signal in Ciz1 b-variant sandwich ELISA without any pre-treatment to dissolve exosomes. For patients whose Ciz1 b-variant epitope containing species is wholly in the exosome fraction, the Ciz1 b-variant epitope may be accessed by treating plasma (type 1) with detergent prior to assay (FIG. 1e,f).

Example 2

Reconstitution of Epitope From Synthetic b-Variant Peptides and Fibrinogen

[0186] The antibody 2B (FIGS. 3a) and 043 (FIG. 1a) recognise Ciz1 b-variant in the region of the unique junction between exon 14b and 15. They do not react with a species with relative mobility of .about.70 kDa in normal plasma (FIG. 3B, C), but do weakly react with synthetic b-variant peptide (FIG. 3B, C). However when combined, synthetic b-variant peptides and normal plasma generate a new, highly reactive species of .about.80 kDa. Similar results are obtained with a synthetic b-variant peptide of a different length (FIG. 3e), quantitatively generating epitope (FIG. 3f).

[0187] Mobility of endogenous b-variant epitope in plasma from cancer patients is sensitive to reducing agent, migrating at .about.340 kDa in the absence of DTT and at .about.70 kDa in the presence of DTT (FIG. 4a). Excision of the 340 kDa complex (FIG. 4b), followed by further separation into constituent polypeptides upon reduction shifts the epitope to .about.70 kDa (FIG. 4c). Excision and elution of this band identified fibrinogen alpha chain by mass spectrometry (FIG. 4d).

[0188] Incubation of purified fibrinogen complex (FIG. 5a) with synthetic b-variant peptides generates a b-variant epitope with mobility similar to the fibrinogen complex (FIG. 5a). Comparison with a-variant peptides, or carboxylated derivatives of b-variant peptides, or with different lengths of b-variant peptides showed that i) reconstitution of epitope is specific to b-variant containing peptides, ii) carboxylation of certain E residues near the splice junction affects reconstitution of epitope, iii) b-variant junction containing peptides of different lengths may constitute the epitope that naturally exists in human plasma.

Example 3

Characterisation of Ciz-1 b-Variant as a Biomarker

[0189] Analysis of CIZ1b was carried out with anti-peptide rabbit polyclonal antibody 2B, which was raised against a short unique peptide spanning the alternatively spliced 14b-15 junction (FIG. 7A), with sequence DEEEIEVRSRDIS (SEQ ID NO: 2--junction indicated by underlined valine). The strategy for generation, validation and purification was described previously (Higgins et al., as above). The western blot reactivity profile for 2B includes a 65-70 kDa entity in SDS-PAGE of plasma from lung cancer patients, plus a 55 kDa entity in plasma from all people (FIG. 7B). The cancer-specific 65-70 kDa species is the CIZ1b biomarker that is referred to here and by Higgins et al. In contrast to plasma, this protein could not be detected in serum samples from the same lung cancer patients (FIG. 7C), suggesting that CIZ1b biomarker is sequestered in coagulated blood. Notably the 55 kDa generic band co-migrates with CIZ1 spec7), identifying the 55 kDa species as a variant or proteolytic fragment of full-length hCIZ1 (which has a predicted full length MW of 99 kDa, NCBI Reference Sequence: NM_012127.2). The width of the bands detected via exon 8 and exon 17 is different, possibly because the exon 8 epitope lies within an alternatively spiced region, while detection via exon 17 would reveal species with or without alternative splicing at exon 8. Thus at least one form of the CIZ1 protein is present in the circulatory system in cancer and non-cancer plasma samples alike, suggesting it to be part of normal physiology.

[0190] Exon 17 and exon 8 epitopes are not present in the 65-70 kDa species recognised by CIZ1b antibody 2B in cancer patients, which means that sequences both upstream and downstream of the CIZ1b epitope are missing from this protein. The data suggest that the 65-70 kDa species is either a complicated CIZ1 splice variant, or an SDS-stable complex between a CIZ1b fragment of CIZ1 and a carrier protein (FIG. 7D).

[0191] A further set of rabbit antibodies was generated using the same immunisation protocol as for 2B (see Higgins et al., as above). This yielded antibody 043, which cleanly and uniquely reacts with the 65-70 kDa band in cancer patients (FIG. 7B). Thus 043 provides a detection tool with applications in other assay formats, including ELISA. The lack of recognition of the 55 kDa species suggests less contribution of junction flanking sequences to its epitope compared to 2B, and suggests that the 55 kDa species does not contain the CIZ1b junction.

[0192] Direct comparison of the ability of these two antibodies to discriminate lung cancer patients by western blot shows them both to be discriminatory, with a high degree of correlation (FIG. 7E), though notably they do not share exactly the same profile across plasma test set. Thus, there is some variation in their epitopes but a common ability to discriminate patients with lung cancer from those without. There is also a small advantage in integrating their output to maximise selectivity.

Example 4

Stability of the Ciz-1 b-Variant Biomarker

[0193] The data support the assertion that CIZ1b is a potent circulating biomarker for lung cancer with significant potential for application in clinical practise. To realise this potential it must be robust enough to withstand variations in sample processing and collection regimes that occur in busy hospitals. Therefore, the stability of the 65-70 kDa cancer-selective CIZ1b species in plasma and whole blood was tested, and compared with the 55 kDa species, using antibody 2B. The data show stability in isolated plasma over at least 6 hours when incubated at 37.degree. C., with gradual decay in both species thereafter. Similarly there was relatively little change during an hour at temperatures up to 50.degree. C., and stability over at least 3 freeze-thaw cycles. Furthermore, when whole blood was left on the bench for up to 24 hours prior to fractionation there was no loss of signal, all of which indicate it to be a robust biomarker suitable for application in a range of clinical settings.

Example 5

Dissociation of the Ciz-1 b-Variant Biomarker Complex

[0194] Under native conditions both 2B and 043 detect a complex in excess of 720 kDa that co-migrates with an abundant protein in plasma (FIG. 8A), but there is very little discrimination between cancer and non-cancer plasmas. Upon further separation through a second dimension under denaturing conditions the cancer-specific 65-70 kDa species is revealed and (for 2B) separated from the 55 kDa generic band (FIG. 8B). Thus cancer-specific detection of CIZ1b in a completely native immunoassay format is unlikely even with 043. The three major denaturing influences (heat, SDS, reducing agent) that reveal cancer-specific signal and were evaluated for their effect on the mobility and discrimination of CIZ1b by 043. This showed that 1% SDS shifts the major reactive species from >720 kDa in native gel, to approximately 340 kDa (FIG. 8C, right), revealing cancer-specific signal, as well as an unspecific band at .about.200 kDa in both cancer and non-cancer samples. Increasing the incubation temperature has a detrimental effect on the cancer-specific species, with maximum differential achieved at 37.degree. C. Inclusion of reducing agent further shifted the mobility of the cancer specific signal to the expected position of 65-70 kDa (FIG. 8C, left).

[0195] Notably, higher concentrations of reducing agent resulted in loss of CIZ1b signal (FIG. 8D,E). Taken together these data suggest that the 65-70 kDa entity is itself a complex that is resistant to standard SDSPAGE denaturing conditions (10 mM DTT) but not more aggressive treatments (500 mM DTT), and that it is normally present within a higher order complex of 340 kDa, which is itself released by SDS from a still bigger complex in excess of 720 kDa (illustrated in FIG. 9A). In fact, fractionation of plasma to enrich for the exosomal compartment differentially partitioned the 55 kDa species (detected via exon 17) and 65-70 kDa species (detected via 043), with the 65-70 kDa species detected exclusively in the pellet, which is a complex fraction that includes exosomes.

Example 6

Identification of the Ciz-1 b-Variant Biomarker Complex

[0196] These observations enable a two-step gel-purification strategy for the 65-70 kDa CIZ1b band. First, the 340 kDa species was isolated from two independent lung cancer patient plasmas (FIG. 10A), followed by further separation in the presence of reducing agent (FIG. 10B). The 65-70 kDa band corresponding to the cancer-specific western blot signal was excised and digested with either trypsin or Asp-N endoprotease, for identification by mass spectrometry (MS). For both enzymatic digestions and two patients, Mascot database searching returned a single significant identification (P<0.05), corresponding to Uniprot P02671; human fibrinogen alpha chain. The endogenous fibrinogen molecule is a hexameric glycoprotein with a pre-cleavage formula mass of 326 kDa and relative mobility of .about.340 kDa, comprised of two sets of three different chains (.alpha., .beta., and .gamma.) of 67, 51 and 45 kDa respectively.

[0197] Notably, CIZ1b was not identified in the 65-70 kDa band after digestion with either enzyme. To determine whether a diagnostic CIZ1b fragment could be observed by MS if present, a short synthetic CIZ1b peptide (b13) and long CIZ1b peptide (b66, Table 2) were digested with Asp-N, which generates the diagnostic fragment DEEEIEVRSR (SEQ ID NO: 16) by cutting either side of the CIZ1b exon junction. The peptide was positively identified post digestion of b13 and b66 by MALDI-MS/MS, though at low intensity relative to other peptides in the digest. Further analysis was performed by LC-MS/MS using both data dependent acquisition (DDA) and targeted selection reaction monitoring (SRM), which focused the analysis to cycle through fragmentation of the expected 2+ and 3+ ions of DEEEIEVRSR (SEQ ID NO: 16), excluding all other precursors, to maximize specificity and sensitivity for this analyte. DEEEIEVRSR (SEQ ID NO: 16) was identified in both the DDA and SRM analyses, indicating that the diagnostic peptide is observable by MS when excised from chemically synthesized peptide (SRM chromatogram).

[0198] However, when the same peptide was spiked into normal human plasma to reconstitute CIZ1b, the diagnostic DEEEIEVRSR (SEQ ID NO: 16) peptide was not detected in the excised 65-70 kDa band. Lack of identification could reflect: i) secondary modifications that alter the expected mass of the CIZ1b diagnostic peptide or impair enzymatic digestion, ii) the more abundant proteins in the sample, primarily fibrinogen alpha chain, causing ion suppression or iii) absolute abundance falling below the limit of detection for the instrumentation after the losses incurred from the PAGE and digestion steps. It should be noted that the peptide is highly acidic, which is likely to reduce ionization efficiency in positive-mode MS, so that even with SRM a small drop in abundance could fall below the limit of detection. It was concluded if the spiked peptide could not be reliably detected at physiologically relevant levels it was unlikely to be possible to detect endogenous CIZ1b, and so followed alternative approaches were followed.

TABLE-US-00002 TABLE 2 Designation Sequence Short CDEEEIEVRSRDIS-NH2 CIZ1b (SEQ ID NO: 22) (b13) Super CEIEVRSR-NH2 short (SEQ ID NO: 17) CIZ1b (b7) Short CDEEEIEVEEELCKQVRSRDISR-NH2 CIZ1a (SEQ ID NO: 18) (a22) Long EIAGQDEDHFITVDAVGCFEGDEEEEE CIZ1b DDEDEEEIEVRSRDISREEWKGSETYS peptide PNTAYGVDFLVP (b66) (SEQ ID NO: 11) Long EIAGQDEDHFITVDAVGCFEGDEEEEE CIZ1a DDEDEEEIEVEEELCKQVRSRDISREE peptide WKGSETYSPNTAYGVDFLVP (a74) (SEQ ID NO: 19) GLA3 CDEE.gamma.IEVRSRDIS-NH2 (SEQ ID NO: 14) GLA4 CDE.gamma.EIEVRSRDIS-NH2 (SEQ ID NO: 23) GLA6 CD.gamma..gamma..gamma.I.gamma.VRSRDIS-NH2 (SEQ ID NO: 15) Exon 17 C-TSSGRPPSQPNTQDKTPSK (SEQ ID NO: 20) C-TARPSQPPLPRRSTRLKT (SEQ ID NO: 21) The 8 amino-acids spliced out of CIZ1b are underlined in non-alternatively spliced sequences, and the junction created by their absence is indicated in CIZ1b sequences by a V. Where indicated peptides contain an additional N-terminal cysteine residue, and amidation of the C-terminus. Carboxylated glutamic acid residues are indicated by .gamma..

Example 7

Epitope Reconstitution of the Ciz-1 b-Variant Biomarker Complex

[0199] In order to confirm that the 65-70 kDa cancer-specific epitope does indeed contain CIZ1b sequences, an epitope reconstitution strategy was adopted. To achieve this, a pair of synthetic peptides spanning the exon14/15 junction (CIZ1b13, and CIZ1a22 which includes the alternatively spliced intervening sequence, Table 2) were incubated with normal human plasma (FIG. 10C), and the output compared to lung cancer patient plasma. The CIZ1b peptide, but not CIZ1a, generated 043 and 2B-reactive epitope of comparable mobility to the endogenous epitope (65 70 kDa), which is far in excess of the relative molecular mass of free peptide and not present in either of the individual components of the reaction (peptide lanes 6, 7, or plasma lane 3). This suggests that CIZ1b peptide forms an SDS/DTT-resistant complex with a carrier protein in human plasma, recreating the CIZ1b biomarker recognised by 2B and 043. Since no mobility difference between endogenous (cancer plasma lane 1) and reconstituted epitope was detected, the data also imply that the CIZ1b fragment contributing to the 65-70 kDa cancer-specific species is very short, in the order of 10-20 amino acids in length. Furthermore, individual molecules may not necessarily have uniform molecular boundaries, possibly accounting for the often-diffuse nature of the band.

[0200] A molar equivalent of the much longer CIZ1b peptide (b66, Table 2) reconstituted reactive epitope less efficiently, and was detectable only by 2B (FIG. 10C lane 2, and at higher concentration). With this peptide the reconstituted signal migrated with greater relative molecular mass, at .about.80 kDa, consistent with the increased size of the contributing peptide. Importantly reconstituted CIZ1b epitope, like endogenous epitope, resists standard denaturing SDS-PAGE conditions (10 mM DTT, 2% SDS, 90.degree. C.), but is dissociated by a more aggressive reducing environment. Taken together the data suggest that, in vivo, the cancer specific epitope is composed of a relatively short fragment of CIZ1 encompassing the exon14b/15 junction, mounted on fibrinogen alpha chain, which itself makes up most of the mass of the 65-70 kDa species. To further confirm this, epitope reconstitution experiments were performed with purified human fibrinogen (FIG. 10D). For both antibodies, reactive epitope was generated at the mobility of fibrinogen complex (340 kDa in non-reducing gels) and the specificity of the signal was confirmed by lack of reactivity with equivalent CIZ1a peptide. Direct ELISA using human fibrinogen complexed with molar equivalents of CIZ1a and CIZ1b peptides (FIG. 10E), confirmed i) the specificity of epitope reconstitution with peptide b13 over a22, ii) negligible signal with fibrinogen alone, and iii) greater reactivity when peptide is mounted on fibrinogen. Moreover, inclusion of the very short CIZ1b peptide b7 (Table 2) revealed differences between 2B and 043; 2B recognises b7 while 043 does not in a manner that is unrelated to the presence of fibrinogen. The existence of CIZ1b epitope in a complex with fibrinogen is consistent with the earlier observations that the biomarker is depleted from serum samples isolated from clotted blood (FIG. 7C).

Example 8

CIZ1b Immunoassay

[0201] Based on knowledge of the composition of CIZ1b biomarker, a sandwich immunoassay format capable of quantitative detection in partially denatured plasma was designed. Antigen capture with CIZ1b antibody 043 from 5 ul of plasma and detection via fibrinogen alpha chain, generated a cancer-specific signal. Specifically, results by western blot with 043 generated ROC AUC 0.823 (P=0.0002) and by ELISA with 043/anti-fibrinogen of 0.830 (P=0.0007, FIG. 11A,B). Thus, the two methods generate very similar outcomes, and the data is significantly correlated.

[0202] This data set, which represents patients with a wide range of conditions presenting at York Hospital respiratory medicine clinics, was also used to evaluate the contribution of the CIZ1b component of the assay, since fibrinogen alone has been reported to have some potential as a biomarker for lung cancer (AIlin et al.; 2016; Int J Cancer 139(7):1493-1500). Quantitative detection of fibrinogen in the linear range returned some discriminatory capability across this set, though relatively poor ROC AUC of 0.628 (p=0.225). This is consistent with western blot evaluation of fibrinogen, which indicated little difference between lung cancer patients and those without malignant disease. Thus capture of CIZ1b is the element that contributes the majority of the cancer selectivity to this assay. The specificity of the configuration was further tested by analysing the sample set after capture with 043, but substituting anti-fibrinogen detector antibody with anti-human IgG (FIG. 11D). Results indicate no discrimination between patients and control plasmas, confirming that anti-fibrinogen is an informative detector reagent that specifically detects a cancer-selective complex retrieved via CIZ1b. Finally, measurement of total IgG levels across set B by direct ELISA (FIG. 11E) was used to normalize the output generated by 043/fibrinogen, leading to a marginal improvement in discrimination and ROC AUC 0.845 (p=0.0002, FIG. 11F).

[0203] The CIZ1b-fibrinogen alpha chain complex ELISA was performed as a sandwich ELISA after partial denaturation of 5 ul of plasma in 100 ul of 0.5% tween20, 1% SDS in PBS, supplemented with 0.5 mM PMSF (protease inhibitors) and incubation at 20.degree. C. for 30 mins with repeated vortexing. Plates (Nunc Maxisorb 442404) were coated with 1 ug of 043 CIZ1b pAb protein A fraction, overnight at 4.degree. C. in 100 ul of 50 mM carbonate pH 9.6, then blocked for two hours at room temperature with 300 ul of filtered 1% BSA in PBS. After three washes in 300 ul of 0.05% tween20 in PBS, analyte was added for 2 hours at room temperature with gentle shaking. After fives washes, captured complex was detected with sheep anti-fibrinogen pAb (AF4786 R&D systems) followed by anti-sheep HRP (Jackson ImmunoResearch 213-032-177), and results developed using 100 ul Sure Blue (KPL 520001) with detection at A450 nm using a FLUOstar OPTIMA plate reader (BMG Labtech).

[0204] For measurement of fibrinogen capture antibody was chicken IgY (1 ug/well, Genway 15-288-22856), and analyte concentration was reduced five orders of magnitude by serial dilution. For measurement of human IgG in direct ELISA, 0.5 ul of plasma was coated directly onto plates in 100 ul of 50 mM carbonate buffer pH 9.6, blocked, washed and detected with anti-IgG (Jackson Immuno Research 709-035-149). For direct ELISA of synthetic analyte, 0.5 ug purified fibrinogen (Sigma F3879) complexed with 100 pmol peptide was coated onto plates in 100 ul of 50 mM carbonate pH 9.6 as above, probe with 043 or 2B and detected with anti-rabbit HRP (Jackson ImmunoResearch).

[0205] Thus, the present sandwich ELISA format is suitable for high-throughput application on hospital platforms, and can reliably quantify circulating CIZ1b biomarker, and can be used to identify patients with early stage lung cancer.

[0206] All publications mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described methods and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in molecular biology or related fields are intended to be within the scope of the following claims.

Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 1063 <210> SEQ ID NO 1 <211> LENGTH: 890 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Full Ciz1 b-variant sequence <400> SEQUENCE: 1 Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln 1 5 10 15 Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln 20 25 30 Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln 35 40 45 Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro 50 55 60 Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu 65 70 75 80 Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly 85 90 95 Leu Asp Gln Phe Ala Met Pro Pro Ala Thr Tyr Asp Thr Ala Gly Leu 100 105 110 Thr Met Pro Thr Ala Thr Leu Gly Asn Leu Arg Gly Tyr Gly Met Ala 115 120 125 Ser Pro Gly Leu Ala Ala Pro Ser Leu Thr Pro Pro Gln Leu Ala Thr 130 135 140 Pro Asn Leu Gln Gln Phe Phe Pro Gln Ala Thr Arg Gln Ser Leu Leu 145 150 155 160 Gly Pro Pro Pro Val Gly Val Pro Met Asn Pro Ser Gln Phe Asn Leu 165 170 175 Ser Gly Arg Asn Pro Gln Lys Gln Ala Arg Thr Ser Ser Ser Thr Thr 180 185 190 Pro Asn Arg Lys Asp Ser Ser Ser Gln Thr Met Pro Val Glu Asp Lys 195 200 205 Ser Asp Pro Pro Glu Gly Ser Glu Glu Ala Ala Glu Pro Arg Met Asp 210 215 220 Thr Pro Glu Asp Gln Asp Leu Pro Pro Cys Pro Glu Asp Ile Ala Lys 225 230 235 240 Glu Lys Arg Thr Pro Ala Pro Glu Pro Glu Pro Cys Glu Ala Ser Glu 245 250 255 Leu Pro Ala Lys Arg Leu Arg Ser Ser Glu Glu Pro Thr Glu Lys Glu 260 265 270 Pro Pro Gly Gln Leu Gln Val Lys Ala Gln Pro Gln Ala Arg Met Thr 275 280 285 Val Pro Lys Gln Thr Gln Thr Pro Asp Leu Leu Pro Glu Ala Leu Glu 290 295 300 Ala Gln Val Leu Pro Arg Phe Gln Pro Arg Val Leu Gln Val Gln Ala 305 310 315 320 Gln Val Gln Ser Gln Thr Gln Pro Arg Ile Pro Ser Thr Asp Thr Gln 325 330 335 Val Gln Pro Lys Leu Gln Lys Gln Ala Gln Thr Gln Thr Ser Pro Glu 340 345 350 His Leu Val Leu Gln Gln Lys Gln Val Gln Pro Gln Leu Gln Gln Glu 355 360 365 Ala Glu Pro Gln Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His 370 375 380 Ser Gln Gly Pro Arg Gln Val Gln Leu Gln Gln Glu Ala Glu Pro Leu 385 390 395 400 Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His Ser Gln Pro Pro 405 410 415 Arg Gln Val Gln Leu Gln Leu Gln Lys Gln Val Gln Thr Gln Thr Tyr 420 425 430 Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His 435 440 445 Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln 450 455 460 Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro 465 470 475 480 Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu 485 490 495 Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln 500 505 510 Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val 515 520 525 Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala 530 535 540 Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Ser Ser Asp Ser Arg Ala 545 550 555 560 Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val 565 570 575 Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln 580 585 590 Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe 595 600 605 Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile 610 615 620 Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg 625 630 635 640 Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys 645 650 655 Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg 660 665 670 Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr 675 680 685 Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val 690 695 700 Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu 705 710 715 720 Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala 725 730 735 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 740 745 750 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 755 760 765 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 770 775 780 Leu Val Pro Val Met Gly Tyr Ile Cys Arg Ile Cys His Lys Phe Tyr 785 790 795 800 His Ser Asn Ser Gly Ala Gln Leu Ser His Cys Lys Ser Leu Gly His 805 810 815 Phe Glu Asn Leu Gln Lys Tyr Lys Ala Ala Lys Asn Pro Ser Pro Thr 820 825 830 Thr Arg Pro Val Ser Arg Arg Cys Ala Ile Asn Ala Arg Asn Ala Leu 835 840 845 Thr Ala Leu Phe Thr Ser Ser Gly Arg Pro Pro Ser Gln Pro Asn Thr 850 855 860 Gln Asp Lys Thr Pro Ser Lys Val Thr Ala Arg Pro Ser Gln Pro Pro 865 870 875 880 Leu Pro Arg Arg Ser Thr Arg Leu Lys Thr 885 890 <210> SEQ ID NO 2 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: sequence comprising the exon 14b/exon 15 amino acid junction sequence <400> SEQUENCE: 2 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 3 <211> LENGTH: 126 <212> TYPE: RNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14b nucleotide sequence <400> SEQUENCE: 3 cugaagucgc uugagaaaga aauugcuggc caagaugagg agcacuucau uacaguggac 60 gcuguggguu gcuucgaggg ugaugaagaa gaggaagagg augaugagga ugaagaagag 120 aucgag 126 <210> SEQ ID NO 4 <211> LENGTH: 150 <212> TYPE: RNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14a nucleotide sequence <400> SEQUENCE: 4 cugaagucgc uugagaaaga aauugcuggc caagaugagg agcacuucau uacaguggac 60 gcuguggguu gcuucgaggg ugaugaagaa gaggaagagg augaugagga ugaagaagag 120 aucgagguug aggaggaacu cugcaagcag 150 <210> SEQ ID NO 5 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14b amino acid sequence <400> SEQUENCE: 5 Leu Lys Ser Leu Glu Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe 1 5 10 15 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 20 25 30 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 35 40 <210> SEQ ID NO 6 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14a amino acid sequence <400> SEQUENCE: 6 Leu Lys Ser Leu Glu Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe 1 5 10 15 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 20 25 30 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys 35 40 45 Lys Gln 50 <210> SEQ ID NO 7 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 15 amino acid sequence <400> SEQUENCE: 7 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 1 5 10 15 Tyr Ser Pro Asn Thr Ala Tyr 20 <210> SEQ ID NO 8 <211> LENGTH: 898 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln 1 5 10 15 Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln 20 25 30 Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln 35 40 45 Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro 50 55 60 Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu 65 70 75 80 Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly 85 90 95 Leu Asp Gln Phe Ala Met Pro Pro Ala Thr Tyr Asp Thr Ala Gly Leu 100 105 110 Thr Met Pro Thr Ala Thr Leu Gly Asn Leu Arg Gly Tyr Gly Met Ala 115 120 125 Ser Pro Gly Leu Ala Ala Pro Ser Leu Thr Pro Pro Gln Leu Ala Thr 130 135 140 Pro Asn Leu Gln Gln Phe Phe Pro Gln Ala Thr Arg Gln Ser Leu Leu 145 150 155 160 Gly Pro Pro Pro Val Gly Val Pro Met Asn Pro Ser Gln Phe Asn Leu 165 170 175 Ser Gly Arg Asn Pro Gln Lys Gln Ala Arg Thr Ser Ser Ser Thr Thr 180 185 190 Pro Asn Arg Lys Asp Ser Ser Ser Gln Thr Met Pro Val Glu Asp Lys 195 200 205 Ser Asp Pro Pro Glu Gly Ser Glu Glu Ala Ala Glu Pro Arg Met Asp 210 215 220 Thr Pro Glu Asp Gln Asp Leu Pro Pro Cys Pro Glu Asp Ile Ala Lys 225 230 235 240 Glu Lys Arg Thr Pro Ala Pro Glu Pro Glu Pro Cys Glu Ala Ser Glu 245 250 255 Leu Pro Ala Lys Arg Leu Arg Ser Ser Glu Glu Pro Thr Glu Lys Glu 260 265 270 Pro Pro Gly Gln Leu Gln Val Lys Ala Gln Pro Gln Ala Arg Met Thr 275 280 285 Val Pro Lys Gln Thr Gln Thr Pro Asp Leu Leu Pro Glu Ala Leu Glu 290 295 300 Ala Gln Val Leu Pro Arg Phe Gln Pro Arg Val Leu Gln Val Gln Ala 305 310 315 320 Gln Val Gln Ser Gln Thr Gln Pro Arg Ile Pro Ser Thr Asp Thr Gln 325 330 335 Val Gln Pro Lys Leu Gln Lys Gln Ala Gln Thr Gln Thr Ser Pro Glu 340 345 350 His Leu Val Leu Gln Gln Lys Gln Val Gln Pro Gln Leu Gln Gln Glu 355 360 365 Ala Glu Pro Gln Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His 370 375 380 Ser Gln Gly Pro Arg Gln Val Gln Leu Gln Gln Glu Ala Glu Pro Leu 385 390 395 400 Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His Ser Gln Pro Pro 405 410 415 Arg Gln Val Gln Leu Gln Leu Gln Lys Gln Val Gln Thr Gln Thr Tyr 420 425 430 Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His 435 440 445 Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln 450 455 460 Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro 465 470 475 480 Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu 485 490 495 Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln 500 505 510 Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val 515 520 525 Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala 530 535 540 Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Ser Ser Asp Ser Arg Ala 545 550 555 560 Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val 565 570 575 Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln 580 585 590 Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe 595 600 605 Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile 610 615 620 Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg 625 630 635 640 Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys 645 650 655 Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg 660 665 670 Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr 675 680 685 Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val 690 695 700 Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu 705 710 715 720 Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala 725 730 735 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 740 745 750 Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser 755 760 765 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 770 775 780 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met Gly Tyr Ile 785 790 795 800 Cys Arg Ile Cys His Lys Phe Tyr His Ser Asn Ser Gly Ala Gln Leu 805 810 815 Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gln Lys Tyr Lys 820 825 830 Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser Arg Arg Cys 835 840 845 Ala Ile Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr Ser Ser Gly 850 855 860 Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys Thr Pro Ser Lys Val 865 870 875 880 Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg Leu 885 890 895 Lys Thr <210> SEQ ID NO 9 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: sequence comprising the exon 14a/exon 15 splice junction <400> SEQUENCE: 9 Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg 1 5 10 15 Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 10 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: excluded sequence from Ciz1 exon 14/exon 15 junction which specifies a Ciz1 b-variant <400> SEQUENCE: 10 Val Glu Glu Glu Leu Cys Lys Gln 1 5 <210> SEQ ID NO 11 <211> LENGTH: 66 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide <400> SEQUENCE: 11 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val Pro 65 <210> SEQ ID NO 12 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long Ciz1 b-variant peptide <400> SEQUENCE: 12 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val 65 <210> SEQ ID NO 13 <211> LENGTH: 72 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long Ciz1 exon 14a peptide <400> SEQUENCE: 13 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Arg Ser Arg Asp 35 40 45 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 60 Ala Tyr Gly Val Asp Phe Leu Val 65 70 <210> SEQ ID NO 14 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA3 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (5)..(5) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 14 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 15 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA6 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(5) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (7)..(7) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 15 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 16 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: diagnostic fragment of CIZ1b <400> SEQUENCE: 16 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 17 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: super short CIZ1b peptide (b7) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (8)..(8) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 17 Cys Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 18 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: short CIZ1a peptide (a22) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (23)..(23) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 18 Cys Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 19 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long CIZ1a peptide (a74) <400> SEQUENCE: 19 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser Arg 35 40 45 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 50 55 60 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 65 70 <210> SEQ ID NO 20 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 17 peptide sequence <400> SEQUENCE: 20 Cys Thr Ser Ser Gly Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys 1 5 10 15 Thr Pro Ser Lys 20 <210> SEQ ID NO 21 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 17 peptide sequence <400> SEQUENCE: 21 Cys Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg 1 5 10 15 Leu Lys Thr <210> SEQ ID NO 22 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: short CIZ1b peptide (b13) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 22 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 23 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA4 peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (4)..(4) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 23 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 24 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 24 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg 35 <210> SEQ ID NO 25 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 25 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg 35 <210> SEQ ID NO 26 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 26 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg 35 <210> SEQ ID NO 27 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 27 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg 35 <210> SEQ ID NO 28 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 28 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg <210> SEQ ID NO 29 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 29 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg <210> SEQ ID NO 30 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 30 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 31 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 31 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 32 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 32 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 33 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 33 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 34 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 34 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 35 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 35 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 36 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 36 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 37 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 37 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 38 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 38 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 39 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 39 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 40 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 40 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 41 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 41 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg 20 <210> SEQ ID NO 42 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 42 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg 20 <210> SEQ ID NO 43 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 43 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg <210> SEQ ID NO 44 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 44 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg <210> SEQ ID NO 45 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 45 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg <210> SEQ ID NO 46 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 46 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 <210> SEQ ID NO 47 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 47 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 <210> SEQ ID NO 48 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 48 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 49 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 49 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 50 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 50 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 51 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 51 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 52 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 52 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 53 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 53 Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 54 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 54 Asp Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 55 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 55 Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 56 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 56 Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 57 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 57 Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 58 <211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 58 Ile Glu Val Arg 1 <210> SEQ ID NO 59 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 59 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser 35 <210> SEQ ID NO 60 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 60 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser 35 <210> SEQ ID NO 61 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 61 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser 35 <210> SEQ ID NO 62 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 62 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser 35 <210> SEQ ID NO 63 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 63 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser 35 <210> SEQ ID NO 64 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 64 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser <210> SEQ ID NO 65 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 65 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser <210> SEQ ID NO 66 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 66 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 67 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 67 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 68 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 68 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 69 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 69 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 70 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 70 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 71 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 71 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 72 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 72 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 73 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 73 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 74 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 74 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 75 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 75 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 76 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 76 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 77 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 77 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser 20 <210> SEQ ID NO 78 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 78 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser 20 <210> SEQ ID NO 79 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 79 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser <210> SEQ ID NO 80 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 80 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser <210> SEQ ID NO 81 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 81 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser <210> SEQ ID NO 82 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 82 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 <210> SEQ ID NO 83 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 83 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 <210> SEQ ID NO 84 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 84 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 85 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 85 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 86 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 86 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 87 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 87 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 88 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 88 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 89 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 89 Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 90 Glu Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 91 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 91 Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 92 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 92 Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 93 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 93 Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 94 <211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 94 Glu Val Arg Ser 1 <210> SEQ ID NO 95 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 95 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg 35 40 <210> SEQ ID NO 96 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 96 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg 35 <210> SEQ ID NO 97 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 97 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg 35 <210> SEQ ID NO 98 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 98 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg 35 <210> SEQ ID NO 99 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 99 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg 35 <210> SEQ ID NO 100 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 100 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg 35 <210> SEQ ID NO 101 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 101 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg <210> SEQ ID NO 102 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 102 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg <210> SEQ ID NO 103 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 103 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 104 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 104 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 105 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 105 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 106 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 106 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 107 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 107 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 108 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 108 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 109 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 109 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 110 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 110 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 111 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 111 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 112 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 112 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 113 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 113 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 114 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 114 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg 20 <210> SEQ ID NO 115 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 115 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg 20 <210> SEQ ID NO 116 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 116 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg <210> SEQ ID NO 117 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 117 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg <210> SEQ ID NO 118 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 118 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg <210> SEQ ID NO 119 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 119 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 <210> SEQ ID NO 120 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 120 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 <210> SEQ ID NO 121 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 121 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 122 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 122 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 123 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 123 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 124 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 124 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 125 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 125 Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 126 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 126 Glu Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 127 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 127 Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 128 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 128 Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 129 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 129 Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 130 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 130 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp 35 40 <210> SEQ ID NO 131 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 131 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp 35 40 <210> SEQ ID NO 132 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 132 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp 35 <210> SEQ ID NO 133 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 133 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp 35 <210> SEQ ID NO 134 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 134 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp 35 <210> SEQ ID NO 135 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 135 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp 35 <210> SEQ ID NO 136 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 136 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp 35 <210> SEQ ID NO 137 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 137 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp <210> SEQ ID NO 138 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 138 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp <210> SEQ ID NO 139 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 139 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 140 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 140 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 141 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 141 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 142 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 142 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 143 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 143 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 144 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 144 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 145 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 145 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 146 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 146 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 147 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 147 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 148 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 148 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 149 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 149 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 150 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 150 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp 20 <210> SEQ ID NO 151 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 151 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp 20 <210> SEQ ID NO 152 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 152 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp <210> SEQ ID NO 153 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 153 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp <210> SEQ ID NO 154 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 154 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp <210> SEQ ID NO 155 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 155 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 <210> SEQ ID NO 156 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 156 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 <210> SEQ ID NO 157 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 157 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 158 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 158 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 159 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 159 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 160 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 160 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 161 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 161 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 162 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 162 Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 163 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 163 Glu Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 164 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 164 Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 165 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 165 Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 166 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 166 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 167 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 167 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 168 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 168 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 169 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 169 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 170 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 170 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 171 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 171 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 172 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 172 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile 35 <210> SEQ ID NO 173 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 173 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile 35 <210> SEQ ID NO 174 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 174 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile <210> SEQ ID NO 175 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 175 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile <210> SEQ ID NO 176 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 176 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 177 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 177 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 178 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 178 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 179 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 179 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 180 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 180 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 181 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 181 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 182 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 182 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 183 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 183 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 184 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 184 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 185 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 185 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 186 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 186 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 187 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 187 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 188 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 188 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile 20 <210> SEQ ID NO 189 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 189 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile <210> SEQ ID NO 190 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 190 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile <210> SEQ ID NO 191 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 191 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile <210> SEQ ID NO 192 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 192 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 <210> SEQ ID NO 193 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 193 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 <210> SEQ ID NO 194 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 194 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 195 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 195 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 196 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 196 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 197 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 197 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 198 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 198 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 199 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 199 Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 200 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 200 Ile Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 201 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 201 Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 202 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 202 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 203 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 203 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 204 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 204 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 205 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 205 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 206 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 206 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 207 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 207 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 208 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 208 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 209 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 209 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser 35 <210> SEQ ID NO 210 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 210 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser 35 <210> SEQ ID NO 211 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 211 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser <210> SEQ ID NO 212 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 212 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser <210> SEQ ID NO 213 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 213 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 214 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 214 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 215 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 215 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 216 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 216 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 217 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 217 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 218 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 218 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 219 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 219 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 220 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 220 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 221 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 221 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 222 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 222 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 223 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 223 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 224 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 224 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 225 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 225 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser 20 <210> SEQ ID NO 226 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 226 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser <210> SEQ ID NO 227 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 227 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser <210> SEQ ID NO 228 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 228 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser <210> SEQ ID NO 229 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 229 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 <210> SEQ ID NO 230 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 230 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 <210> SEQ ID NO 231 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 231 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 232 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 232 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 233 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 234 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 234 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 235 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 235 Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 <210> SEQ ID NO 236 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 236 Glu Val Arg Ser Arg Asp Ile Ser 1 5 <210> SEQ ID NO 237 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 237 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 238 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 238 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 239 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 239 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 240 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 240 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 241 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 241 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 242 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 242 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 243 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 243 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 244 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 244 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 245 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 245 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg 35 <210> SEQ ID NO 246 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 246 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg 35 <210> SEQ ID NO 247 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 247 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg <210> SEQ ID NO 248 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 248 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg <210> SEQ ID NO 249 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 249 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 250 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 250 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 251 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 251 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 252 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 252 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 253 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 253 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 254 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 254 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 255 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 255 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 256 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 256 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 257 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 257 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 258 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 258 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 259 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 259 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 260 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 260 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 261 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 261 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg 20 <210> SEQ ID NO 262 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 262 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg <210> SEQ ID NO 263 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 263 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg <210> SEQ ID NO 264 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 264 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg <210> SEQ ID NO 265 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 265 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 <210> SEQ ID NO 266 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 266 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 <210> SEQ ID NO 267 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 267 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 268 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 268 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 269 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 269 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 270 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 270 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 271 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 271 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 272 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 272 Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 <210> SEQ ID NO 273 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 273 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 45 <210> SEQ ID NO 274 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 274 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 275 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 275 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 276 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 276 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 277 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 277 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 278 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 278 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 279 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 279 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 280 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 280 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 281 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 281 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 282 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 282 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu 35 <210> SEQ ID NO 283 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 283 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu 35 <210> SEQ ID NO 284 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 284 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu <210> SEQ ID NO 285 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 285 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu <210> SEQ ID NO 286 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 286 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 287 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 287 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 288 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 288 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 289 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 289 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 290 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 290 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 291 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 291 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 292 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 292 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 293 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 293 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 294 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 294 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 295 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 295 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 296 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 296 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 297 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 297 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 298 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 298 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu 20 <210> SEQ ID NO 299 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 299 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu <210> SEQ ID NO 300 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 300 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu <210> SEQ ID NO 301 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 301 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu <210> SEQ ID NO 302 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 302 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 <210> SEQ ID NO 303 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 303 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 <210> SEQ ID NO 304 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 304 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 305 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 305 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 306 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 306 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 307 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 307 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 308 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 309 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 309 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 45 <210> SEQ ID NO 310 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 310 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 45 <210> SEQ ID NO 311 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 311 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 312 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 312 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 313 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 313 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 314 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 314 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 315 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 315 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 316 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 316 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 317 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 317 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 318 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 318 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 319 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 319 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu 35 <210> SEQ ID NO 320 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 320 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu 35 <210> SEQ ID NO 321 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 321 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu <210> SEQ ID NO 322 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 322 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu <210> SEQ ID NO 323 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 323 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 324 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 324 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 325 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 325 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 326 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 326 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 327 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 327 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 328 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 328 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 329 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 329 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 330 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 330 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 331 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 331 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 332 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 332 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 333 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 333 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 334 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 334 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 335 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 335 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu 20 <210> SEQ ID NO 336 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 336 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu <210> SEQ ID NO 337 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 337 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu <210> SEQ ID NO 338 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 338 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu <210> SEQ ID NO 339 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 339 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 <210> SEQ ID NO 340 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 340 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 <210> SEQ ID NO 341 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 341 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 342 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 342 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 343 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 343 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 344 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 344 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 345 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 345 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 346 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 346 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 347 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 347 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 348 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 348 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 349 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 349 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 350 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 350 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 351 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 351 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 352 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 352 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 353 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 353 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 354 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 354 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 355 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 355 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 356 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 356 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp 35 <210> SEQ ID NO 357 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 357 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp 35 <210> SEQ ID NO 358 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 358 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp <210> SEQ ID NO 359 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 359 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp <210> SEQ ID NO 360 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 360 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 361 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 361 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 362 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 362 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 363 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 363 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 364 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 364 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 365 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 365 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 366 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 366 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 367 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 367 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 368 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 368 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 369 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 369 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 370 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 370 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 371 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 371 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 372 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 372 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp 20 <210> SEQ ID NO 373 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 373 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp <210> SEQ ID NO 374 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 374 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp <210> SEQ ID NO 375 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 375 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp <210> SEQ ID NO 376 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 376 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 <210> SEQ ID NO 377 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 377 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 <210> SEQ ID NO 378 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 378 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 379 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 379 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 380 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 380 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 381 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 381 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 382 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 382 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 383 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 383 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 384 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 384 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 385 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 385 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 386 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 386 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 387 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 387 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 388 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 388 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 389 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 389 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 390 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 390 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 391 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 391 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 392 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 392 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 393 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 393 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys 35 <210> SEQ ID NO 394 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 394 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys 35 <210> SEQ ID NO 395 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 395 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys <210> SEQ ID NO 396 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 396 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys <210> SEQ ID NO 397 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 397 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 398 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 398 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 399 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 399 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 400 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 400 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 401 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 401 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 402 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 402 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 403 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 403 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 404 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 404 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 405 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 405 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 406 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 406 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 407 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 407 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 408 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 408 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 409 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 409 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys 20 <210> SEQ ID NO 410 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 410 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys <210> SEQ ID NO 411 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 411 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys <210> SEQ ID NO 412 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 412 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys <210> SEQ ID NO 413 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 413 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 <210> SEQ ID NO 414 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 414 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 <210> SEQ ID NO 415 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 415 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 <210> SEQ ID NO 416 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 416 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 <210> SEQ ID NO 417 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 417 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly <210> SEQ ID NO 418 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 418 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 419 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 419 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 420 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 420 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 421 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 421 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 422 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 422 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 423 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 423 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 424 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 424 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 425 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 425 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 426 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 426 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 427 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 427 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 428 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 428 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 429 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 429 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 430 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 430 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly 35 <210> SEQ ID NO 431 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 431 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly 35 <210> SEQ ID NO 432 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 432 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly <210> SEQ ID NO 433 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 433 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly <210> SEQ ID NO 434 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 434 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 435 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 435 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 436 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 436 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 437 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 437 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 438 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 438 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 439 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 439 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 440 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 440 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 441 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 441 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 442 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 442 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 443 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 443 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 444 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 444 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 445 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 445 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 446 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 446 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly 20 <210> SEQ ID NO 447 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 447 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly <210> SEQ ID NO 448 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 448 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly <210> SEQ ID NO 449 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 449 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly <210> SEQ ID NO 450 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 450 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 <210> SEQ ID NO 451 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 451 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 <210> SEQ ID NO 452 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 452 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 <210> SEQ ID NO 453 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 453 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser 50 <210> SEQ ID NO 454 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 454 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser <210> SEQ ID NO 455 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 455 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 456 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 456 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 457 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 457 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 458 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 458 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 459 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 459 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 460 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 460 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 461 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 461 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 462 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 462 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 463 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 463 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 464 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 464 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 465 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 465 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 466 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 466 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 467 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 467 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser 35 <210> SEQ ID NO 468 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 468 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser 35 <210> SEQ ID NO 469 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 469 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser <210> SEQ ID NO 470 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 470 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser <210> SEQ ID NO 471 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 471 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 472 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 472 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 473 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 473 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 474 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 474 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 475 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 475 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 476 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 476 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 477 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 477 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 478 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 478 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 479 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 479 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 480 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 480 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 481 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 481 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 482 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 482 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 483 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 483 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser 20 <210> SEQ ID NO 484 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 484 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser <210> SEQ ID NO 485 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 485 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser <210> SEQ ID NO 486 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 486 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser <210> SEQ ID NO 487 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 487 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 <210> SEQ ID NO 488 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 488 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 <210> SEQ ID NO 489 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 489 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu 50 <210> SEQ ID NO 490 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 490 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu 50 <210> SEQ ID NO 491 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 491 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu <210> SEQ ID NO 492 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 492 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 493 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 493 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 494 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 494 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 495 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 495 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 496 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 496 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 497 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 497 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 498 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 498 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 499 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 499 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 500 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 500 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 501 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 501 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 502 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 502 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 503 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 503 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 504 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 504 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu 35 <210> SEQ ID NO 505 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 505 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu 35 <210> SEQ ID NO 506 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 506 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu <210> SEQ ID NO 507 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 507 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu <210> SEQ ID NO 508 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 508 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 509 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 509 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 510 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 510 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 511 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 511 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 512 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 512 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 513 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 513 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 514 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 514 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 515 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 515 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 516 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 516 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 517 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 517 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 518 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 518 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 519 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 519 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 520 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 520 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu 20 <210> SEQ ID NO 521 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 521 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu <210> SEQ ID NO 522 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 522 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu <210> SEQ ID NO 523 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 523 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu <210> SEQ ID NO 524 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 524 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 <210> SEQ ID NO 525 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 525 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr 50 <210> SEQ ID NO 526 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 526 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr 50 <210> SEQ ID NO 527 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 527 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr 50 <210> SEQ ID NO 528 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 528 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr <210> SEQ ID NO 529 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 529 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 530 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 530 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 531 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 531 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 532 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 532 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 533 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 533 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 534 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 534 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 535 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 535 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 536 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 536 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 537 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 537 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 538 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 538 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 539 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 539 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 540 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 540 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 541 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 541 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr 35 <210> SEQ ID NO 542 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 542 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr 35 <210> SEQ ID NO 543 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 543 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr <210> SEQ ID NO 544 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 544 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr <210> SEQ ID NO 545 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 545 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 546 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 546 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 547 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 547 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 548 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 548 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 549 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 549 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 550 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 550 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 551 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 551 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 552 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 552 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 553 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 553 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 554 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 554 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 555 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 555 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 556 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 556 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 557 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 557 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr 20 <210> SEQ ID NO 558 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 558 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr <210> SEQ ID NO 559 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 559 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr <210> SEQ ID NO 560 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 560 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr <210> SEQ ID NO 561 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 561 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr 50 <210> SEQ ID NO 562 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 562 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr 50 <210> SEQ ID NO 563 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 563 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr 50 <210> SEQ ID NO 564 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 564 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr 50 <210> SEQ ID NO 565 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 565 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr <210> SEQ ID NO 566 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 566 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 567 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 567 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 568 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 568 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 569 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 569 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 570 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 570 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 571 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 571 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 572 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 572 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 573 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 573 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 574 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 574 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 575 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 575 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 576 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 576 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 577 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 577 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 578 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 578 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr 35 <210> SEQ ID NO 579 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 579 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr 35 <210> SEQ ID NO 580 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 580 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr <210> SEQ ID NO 581 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 581 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr <210> SEQ ID NO 582 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 582 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 583 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 583 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 584 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 584 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 585 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 585 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 586 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 586 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 587 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 587 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 588 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 588 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 589 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 589 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 590 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 590 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 591 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 591 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 592 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 592 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 593 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 593 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 594 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 594 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr 20 <210> SEQ ID NO 595 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 595 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr <210> SEQ ID NO 596 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 596 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr <210> SEQ ID NO 597 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 597 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser 50 <210> SEQ ID NO 598 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 598 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser 50 <210> SEQ ID NO 599 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 599 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser 50 <210> SEQ ID NO 600 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 600 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser 50 <210> SEQ ID NO 601 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 601 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser 50 <210> SEQ ID NO 602 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 602 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser <210> SEQ ID NO 603 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 603 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 604 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 604 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 605 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 605 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 606 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 606 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 607 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 607 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 608 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 608 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 609 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 609 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 610 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 610 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 611 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 611 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 612 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 612 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 613 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 613 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 614 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 614 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 615 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 615 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser 35 <210> SEQ ID NO 616 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 616 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser 35 <210> SEQ ID NO 617 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 617 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser <210> SEQ ID NO 618 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 618 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser <210> SEQ ID NO 619 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 619 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 620 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 620 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 621 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 621 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 622 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 622 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 623 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 623 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 624 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 624 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 625 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 625 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 626 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 626 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 627 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 627 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 628 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 628 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 629 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 629 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 630 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 630 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 631 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 631 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser 20 <210> SEQ ID NO 632 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 632 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser <210> SEQ ID NO 633 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 633 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro 50 55 <210> SEQ ID NO 634 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 634 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro 50 <210> SEQ ID NO 635 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 635 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro 50 <210> SEQ ID NO 636 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 636 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro 50 <210> SEQ ID NO 637 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 637 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro 50 <210> SEQ ID NO 638 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 638 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro 50 <210> SEQ ID NO 639 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 639 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro <210> SEQ ID NO 640 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 640 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 641 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 641 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 642 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 642 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 643 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 643 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 644 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 644 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 645 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 645 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 646 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 646 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 647 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 647 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 648 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 648 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 649 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 649 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 650 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 650 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 651 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 651 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 652 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 652 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro 35 <210> SEQ ID NO 653 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 653 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro 35 <210> SEQ ID NO 654 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 654 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro <210> SEQ ID NO 655 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 655 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro <210> SEQ ID NO 656 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 656 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 657 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 657 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 658 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 658 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 659 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 659 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 660 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 660 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 661 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 661 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 662 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 662 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 663 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 663 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 664 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 664 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 665 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 665 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 666 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 666 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 667 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 667 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 668 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 668 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro 20 <210> SEQ ID NO 669 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 669 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn 50 55 <210> SEQ ID NO 670 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 670 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn 50 55 <210> SEQ ID NO 671 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 671 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn 50 <210> SEQ ID NO 672 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 672 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn 50 <210> SEQ ID NO 673 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 673 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn 50 <210> SEQ ID NO 674 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 674 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn 50 <210> SEQ ID NO 675 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 675 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn 50 <210> SEQ ID NO 676 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 676 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn <210> SEQ ID NO 677 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 677 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 678 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 678 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 679 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 679 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 680 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 680 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 681 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 681 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 682 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 682 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 683 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 683 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 684 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 684 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 685 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 685 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 686 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 686 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 687 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 687 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 688 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 688 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 689 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 689 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn 35 <210> SEQ ID NO 690 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 690 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn 35 <210> SEQ ID NO 691 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 691 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn <210> SEQ ID NO 692 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 692 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn <210> SEQ ID NO 693 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 693 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 694 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 694 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 695 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 695 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 696 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 696 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 697 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 697 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 698 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 698 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 699 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 699 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 700 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 700 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 701 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 701 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 702 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 702 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 703 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 703 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 704 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 704 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 705 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 705 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 706 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 706 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 707 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 707 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 708 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 708 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr 50 <210> SEQ ID NO 709 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 709 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr 50 <210> SEQ ID NO 710 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 710 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr 50 <210> SEQ ID NO 711 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 711 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr 50 <210> SEQ ID NO 712 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 712 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr 50 <210> SEQ ID NO 713 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 713 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr <210> SEQ ID NO 714 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 714 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 715 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 715 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 716 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 716 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 717 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 717 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 718 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 718 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 719 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 719 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 720 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 720 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 721 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 721 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 722 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 722 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 723 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 723 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr 35 <210> SEQ ID NO 724 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 724 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr 35 <210> SEQ ID NO 725 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 725 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr 35 <210> SEQ ID NO 726 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 726 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr 35 <210> SEQ ID NO 727 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 727 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr 35 <210> SEQ ID NO 728 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 728 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr <210> SEQ ID NO 729 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 729 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr <210> SEQ ID NO 730 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 730 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 731 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 731 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 732 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 732 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 733 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 733 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 734 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 734 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 735 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 735 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 736 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 736 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 737 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 737 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 738 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 738 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 739 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 739 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 740 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 740 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 741 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 741 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 742 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 742 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 743 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 743 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 744 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 744 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 745 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 745 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala 50 <210> SEQ ID NO 746 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 746 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala 50 <210> SEQ ID NO 747 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 747 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala 50 <210> SEQ ID NO 748 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 748 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala 50 <210> SEQ ID NO 749 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 749 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala 50 <210> SEQ ID NO 750 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 750 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala <210> SEQ ID NO 751 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 751 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 752 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 752 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 753 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 753 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 754 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 754 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 755 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 755 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 756 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 756 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 757 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 757 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 758 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 758 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 759 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 759 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 760 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 760 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala 35 <210> SEQ ID NO 761 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 761 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala 35 <210> SEQ ID NO 762 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 762 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala 35 <210> SEQ ID NO 763 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 763 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala 35 <210> SEQ ID NO 764 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 764 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala 35 <210> SEQ ID NO 765 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 765 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala <210> SEQ ID NO 766 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 766 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala <210> SEQ ID NO 767 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 767 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 768 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 768 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 769 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 769 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 770 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 770 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 771 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 771 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 772 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 772 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 773 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 773 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 774 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 774 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 775 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 775 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala 20 <210> SEQ ID NO 776 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 776 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala 20 <210> SEQ ID NO 777 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 777 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 778 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 778 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 779 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 779 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 780 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 780 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 781 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 781 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 782 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 782 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr 50 <210> SEQ ID NO 783 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 783 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr 50 <210> SEQ ID NO 784 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 784 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr 50 <210> SEQ ID NO 785 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 785 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr 50 <210> SEQ ID NO 786 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 786 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr 50 <210> SEQ ID NO 787 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 787 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr <210> SEQ ID NO 788 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 788 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 789 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 789 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 790 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 790 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 791 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 791 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 792 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 792 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 793 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 793 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 794 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 794 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 795 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 795 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 796 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 796 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 797 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 797 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 798 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 798 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 799 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 799 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 800 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 800 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr 35 <210> SEQ ID NO 801 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 801 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr 35 <210> SEQ ID NO 802 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 802 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr <210> SEQ ID NO 803 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 803 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr <210> SEQ ID NO 804 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 804 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 805 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 805 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 806 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 806 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 807 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 807 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 808 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 808 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 809 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 809 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 810 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 810 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 811 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 811 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 812 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 812 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr 20 <210> SEQ ID NO 813 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 813 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 60 <210> SEQ ID NO 814 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 814 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 815 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 815 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 816 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 816 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 817 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 817 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 818 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 818 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 819 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 819 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly 50 <210> SEQ ID NO 820 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 820 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly 50 <210> SEQ ID NO 821 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 821 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly 50 <210> SEQ ID NO 822 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 822 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly 50 <210> SEQ ID NO 823 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 823 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly 50 <210> SEQ ID NO 824 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 824 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly <210> SEQ ID NO 825 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 825 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 826 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 826 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 827 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 827 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 828 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 828 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 829 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 829 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 830 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 830 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 831 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 831 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 832 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 832 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 833 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 833 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 834 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 834 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 835 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 835 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 836 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 836 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 837 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 837 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly 35 <210> SEQ ID NO 838 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 838 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly 35 <210> SEQ ID NO 839 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 839 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly <210> SEQ ID NO 840 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 840 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly <210> SEQ ID NO 841 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 841 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 842 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 842 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 843 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 843 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 844 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 844 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 845 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 845 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 846 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 846 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 847 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 847 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 848 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 848 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 849 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 849 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 60 <210> SEQ ID NO 850 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 850 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 60 <210> SEQ ID NO 851 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 851 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 852 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 852 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 853 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 853 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 854 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 854 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 855 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 855 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 856 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 856 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val 50 <210> SEQ ID NO 857 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 857 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val 50 <210> SEQ ID NO 858 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 858 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val 50 <210> SEQ ID NO 859 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 859 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val 50 <210> SEQ ID NO 860 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 860 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val 50 <210> SEQ ID NO 861 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 861 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val <210> SEQ ID NO 862 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 862 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 863 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 863 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 864 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 864 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 865 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 865 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 866 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 866 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 867 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 867 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 868 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 868 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 869 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 869 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 870 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 870 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 871 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 871 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 872 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 872 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 873 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 873 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 874 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 874 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val 35 <210> SEQ ID NO 875 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 875 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val 35 <210> SEQ ID NO 876 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 876 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val <210> SEQ ID NO 877 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 877 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val <210> SEQ ID NO 878 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 878 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 879 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 879 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 880 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 880 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 881 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 881 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 882 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 882 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 883 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 883 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 884 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 884 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 885 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 885 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 886 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 886 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 887 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 887 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 888 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 888 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 889 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 889 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 890 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 890 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 891 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 891 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 892 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 892 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 893 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 893 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp 50 <210> SEQ ID NO 894 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 894 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp 50 <210> SEQ ID NO 895 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 895 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp 50 <210> SEQ ID NO 896 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 896 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp 50 <210> SEQ ID NO 897 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 897 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp 50 <210> SEQ ID NO 898 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 898 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp <210> SEQ ID NO 899 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 899 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 900 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 900 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 901 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 901 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 902 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 902 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 903 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 903 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 904 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 904 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 905 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 905 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 906 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 906 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 907 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 907 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 908 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 908 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp 35 <210> SEQ ID NO 909 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 909 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp 35 <210> SEQ ID NO 910 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 910 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp 35 <210> SEQ ID NO 911 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 911 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp 35 <210> SEQ ID NO 912 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 912 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp 35 <210> SEQ ID NO 913 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 913 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp <210> SEQ ID NO 914 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 914 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp <210> SEQ ID NO 915 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 915 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 916 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 916 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 917 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 917 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 918 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 918 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 919 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 919 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 920 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 920 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 921 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 921 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 922 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 922 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 923 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 923 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 924 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 924 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 925 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 925 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 926 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 926 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 927 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 927 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 928 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 928 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 929 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 929 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 930 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 930 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe 50 <210> SEQ ID NO 931 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 931 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe 50 <210> SEQ ID NO 932 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 932 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe 50 <210> SEQ ID NO 933 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 933 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe 50 <210> SEQ ID NO 934 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 934 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe 50 <210> SEQ ID NO 935 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 935 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe <210> SEQ ID NO 936 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 936 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 937 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 937 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 938 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 938 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 939 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 939 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 940 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 940 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 941 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 941 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 942 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 942 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 943 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 943 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 944 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 944 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 945 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 945 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 946 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 946 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 947 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 947 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 948 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 948 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe 35 <210> SEQ ID NO 949 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 949 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe 35 <210> SEQ ID NO 950 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 950 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe <210> SEQ ID NO 951 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 951 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe <210> SEQ ID NO 952 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 952 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 953 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 953 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 954 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 954 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 955 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 955 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 <210> SEQ ID NO 956 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 956 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 <210> SEQ ID NO 957 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 957 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 958 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 958 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 959 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 959 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 960 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 960 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 961 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 961 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 962 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 962 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 963 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 963 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 964 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 964 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 965 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 965 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 966 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 966 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 967 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 967 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu 50 <210> SEQ ID NO 968 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 968 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu 50 <210> SEQ ID NO 969 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 969 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu 50 <210> SEQ ID NO 970 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 970 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu 50 <210> SEQ ID NO 971 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 971 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe Leu 50 <210> SEQ ID NO 972 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 972 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu <210> SEQ ID NO 973 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 973 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 974 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 974 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 975 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 975 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 976 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 976 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 977 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 977 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 978 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 978 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 979 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 979 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 980 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 980 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 981 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 981 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 982 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 982 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu 35 <210> SEQ ID NO 983 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 983 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu 35 <210> SEQ ID NO 984 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 984 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu 35 <210> SEQ ID NO 985 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 985 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu 35 <210> SEQ ID NO 986 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 986 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu 35 <210> SEQ ID NO 987 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 987 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu <210> SEQ ID NO 988 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 988 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu <210> SEQ ID NO 989 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 989 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 990 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 990 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 991 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 991 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 992 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 992 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 <210> SEQ ID NO 993 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 993 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val 65 <210> SEQ ID NO 994 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 994 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 995 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 995 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 996 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 996 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 997 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 997 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 998 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 998 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 999 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 999 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1000 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1000 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1001 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1001 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1002 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1002 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1003 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1003 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1004 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1004 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu Val 50 <210> SEQ ID NO 1005 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1005 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu Val 50 <210> SEQ ID NO 1006 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1006 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu Val 50 <210> SEQ ID NO 1007 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1007 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe Leu Val 50 <210> SEQ ID NO 1008 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1008 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu Val 50 <210> SEQ ID NO 1009 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1009 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 Val <210> SEQ ID NO 1010 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1010 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1011 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1011 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1012 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1012 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1013 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1013 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1014 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1014 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1015 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1015 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1016 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1016 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1017 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1017 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1018 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1018 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1019 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1019 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu Val 35 <210> SEQ ID NO 1020 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1020 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu Val 35 <210> SEQ ID NO 1021 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1021 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu Val 35 <210> SEQ ID NO 1022 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1022 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu Val 35 <210> SEQ ID NO 1023 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1023 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu Val 35 <210> SEQ ID NO 1024 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1024 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu Val <210> SEQ ID NO 1025 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1025 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 Val <210> SEQ ID NO 1026 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1026 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1027 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1027 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1028 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1028 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1029 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1029 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 Pro 65 <210> SEQ ID NO 1030 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1030 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1031 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1031 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1032 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1032 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1033 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1033 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1034 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1034 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1035 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1035 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1036 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1036 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1037 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1037 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1038 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1038 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1039 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1039 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1040 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1040 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu Val Pro 50 <210> SEQ ID NO 1041 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1041 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu Val Pro 50 <210> SEQ ID NO 1042 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1042 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe Leu Val Pro 50 <210> SEQ ID NO 1043 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1043 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu Val Pro 50 <210> SEQ ID NO 1044 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1044 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 Val Pro 50 <210> SEQ ID NO 1045 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1045 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 Pro <210> SEQ ID NO 1046 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1046 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1047 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1047 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1048 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1048 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1049 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1049 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1050 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1050 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1051 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1051 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1052 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1052 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1053 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1053 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1054 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1054 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1055 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1055 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1056 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1056 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1057 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1057 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1058 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1058 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu Val Pro 35 <210> SEQ ID NO 1059 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1059 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu Val Pro 35 <210> SEQ ID NO 1060 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1060 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 Val Pro <210> SEQ ID NO 1061 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1061 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 Pro <210> SEQ ID NO 1062 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1062 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 20 25 30 <210> SEQ ID NO 1063 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1063 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 20 25 30

1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 1063 <210> SEQ ID NO 1 <211> LENGTH: 890 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Full Ciz1 b-variant sequence <400> SEQUENCE: 1 Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln 1 5 10 15 Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln 20 25 30 Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln 35 40 45 Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro 50 55 60 Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu 65 70 75 80 Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly 85 90 95 Leu Asp Gln Phe Ala Met Pro Pro Ala Thr Tyr Asp Thr Ala Gly Leu 100 105 110 Thr Met Pro Thr Ala Thr Leu Gly Asn Leu Arg Gly Tyr Gly Met Ala 115 120 125 Ser Pro Gly Leu Ala Ala Pro Ser Leu Thr Pro Pro Gln Leu Ala Thr 130 135 140 Pro Asn Leu Gln Gln Phe Phe Pro Gln Ala Thr Arg Gln Ser Leu Leu 145 150 155 160 Gly Pro Pro Pro Val Gly Val Pro Met Asn Pro Ser Gln Phe Asn Leu 165 170 175 Ser Gly Arg Asn Pro Gln Lys Gln Ala Arg Thr Ser Ser Ser Thr Thr 180 185 190 Pro Asn Arg Lys Asp Ser Ser Ser Gln Thr Met Pro Val Glu Asp Lys 195 200 205 Ser Asp Pro Pro Glu Gly Ser Glu Glu Ala Ala Glu Pro Arg Met Asp 210 215 220 Thr Pro Glu Asp Gln Asp Leu Pro Pro Cys Pro Glu Asp Ile Ala Lys 225 230 235 240 Glu Lys Arg Thr Pro Ala Pro Glu Pro Glu Pro Cys Glu Ala Ser Glu 245 250 255 Leu Pro Ala Lys Arg Leu Arg Ser Ser Glu Glu Pro Thr Glu Lys Glu 260 265 270 Pro Pro Gly Gln Leu Gln Val Lys Ala Gln Pro Gln Ala Arg Met Thr 275 280 285 Val Pro Lys Gln Thr Gln Thr Pro Asp Leu Leu Pro Glu Ala Leu Glu 290 295 300 Ala Gln Val Leu Pro Arg Phe Gln Pro Arg Val Leu Gln Val Gln Ala 305 310 315 320 Gln Val Gln Ser Gln Thr Gln Pro Arg Ile Pro Ser Thr Asp Thr Gln 325 330 335 Val Gln Pro Lys Leu Gln Lys Gln Ala Gln Thr Gln Thr Ser Pro Glu 340 345 350 His Leu Val Leu Gln Gln Lys Gln Val Gln Pro Gln Leu Gln Gln Glu 355 360 365 Ala Glu Pro Gln Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His 370 375 380 Ser Gln Gly Pro Arg Gln Val Gln Leu Gln Gln Glu Ala Glu Pro Leu 385 390 395 400 Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His Ser Gln Pro Pro 405 410 415 Arg Gln Val Gln Leu Gln Leu Gln Lys Gln Val Gln Thr Gln Thr Tyr 420 425 430 Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His 435 440 445 Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln 450 455 460 Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro 465 470 475 480 Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu 485 490 495 Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln 500 505 510 Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val 515 520 525 Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala 530 535 540 Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Ser Ser Asp Ser Arg Ala 545 550 555 560 Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val 565 570 575 Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln 580 585 590 Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe 595 600 605 Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile 610 615 620 Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg 625 630 635 640 Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys 645 650 655 Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg 660 665 670 Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr 675 680 685 Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val 690 695 700 Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu 705 710 715 720 Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala 725 730 735 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 740 745 750 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 755 760 765 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 770 775 780 Leu Val Pro Val Met Gly Tyr Ile Cys Arg Ile Cys His Lys Phe Tyr 785 790 795 800 His Ser Asn Ser Gly Ala Gln Leu Ser His Cys Lys Ser Leu Gly His 805 810 815 Phe Glu Asn Leu Gln Lys Tyr Lys Ala Ala Lys Asn Pro Ser Pro Thr 820 825 830 Thr Arg Pro Val Ser Arg Arg Cys Ala Ile Asn Ala Arg Asn Ala Leu 835 840 845 Thr Ala Leu Phe Thr Ser Ser Gly Arg Pro Pro Ser Gln Pro Asn Thr 850 855 860 Gln Asp Lys Thr Pro Ser Lys Val Thr Ala Arg Pro Ser Gln Pro Pro 865 870 875 880 Leu Pro Arg Arg Ser Thr Arg Leu Lys Thr 885 890 <210> SEQ ID NO 2 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: sequence comprising the exon 14b/exon 15 amino acid junction sequence <400> SEQUENCE: 2 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 3 <211> LENGTH: 126 <212> TYPE: RNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14b nucleotide sequence <400> SEQUENCE: 3 cugaagucgc uugagaaaga aauugcuggc caagaugagg agcacuucau uacaguggac 60 gcuguggguu gcuucgaggg ugaugaagaa gaggaagagg augaugagga ugaagaagag 120 aucgag 126 <210> SEQ ID NO 4 <211> LENGTH: 150 <212> TYPE: RNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14a nucleotide sequence <400> SEQUENCE: 4 cugaagucgc uugagaaaga aauugcuggc caagaugagg agcacuucau uacaguggac 60 gcuguggguu gcuucgaggg ugaugaagaa gaggaagagg augaugagga ugaagaagag 120 aucgagguug aggaggaacu cugcaagcag 150 <210> SEQ ID NO 5 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14b amino acid sequence <400> SEQUENCE: 5 Leu Lys Ser Leu Glu Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe 1 5 10 15 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 20 25 30 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 35 40 <210> SEQ ID NO 6

<211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 14a amino acid sequence <400> SEQUENCE: 6 Leu Lys Ser Leu Glu Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe 1 5 10 15 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 20 25 30 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys 35 40 45 Lys Gln 50 <210> SEQ ID NO 7 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 15 amino acid sequence <400> SEQUENCE: 7 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 1 5 10 15 Tyr Ser Pro Asn Thr Ala Tyr 20 <210> SEQ ID NO 8 <211> LENGTH: 898 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln 1 5 10 15 Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln 20 25 30 Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln 35 40 45 Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro 50 55 60 Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu 65 70 75 80 Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly 85 90 95 Leu Asp Gln Phe Ala Met Pro Pro Ala Thr Tyr Asp Thr Ala Gly Leu 100 105 110 Thr Met Pro Thr Ala Thr Leu Gly Asn Leu Arg Gly Tyr Gly Met Ala 115 120 125 Ser Pro Gly Leu Ala Ala Pro Ser Leu Thr Pro Pro Gln Leu Ala Thr 130 135 140 Pro Asn Leu Gln Gln Phe Phe Pro Gln Ala Thr Arg Gln Ser Leu Leu 145 150 155 160 Gly Pro Pro Pro Val Gly Val Pro Met Asn Pro Ser Gln Phe Asn Leu 165 170 175 Ser Gly Arg Asn Pro Gln Lys Gln Ala Arg Thr Ser Ser Ser Thr Thr 180 185 190 Pro Asn Arg Lys Asp Ser Ser Ser Gln Thr Met Pro Val Glu Asp Lys 195 200 205 Ser Asp Pro Pro Glu Gly Ser Glu Glu Ala Ala Glu Pro Arg Met Asp 210 215 220 Thr Pro Glu Asp Gln Asp Leu Pro Pro Cys Pro Glu Asp Ile Ala Lys 225 230 235 240 Glu Lys Arg Thr Pro Ala Pro Glu Pro Glu Pro Cys Glu Ala Ser Glu 245 250 255 Leu Pro Ala Lys Arg Leu Arg Ser Ser Glu Glu Pro Thr Glu Lys Glu 260 265 270 Pro Pro Gly Gln Leu Gln Val Lys Ala Gln Pro Gln Ala Arg Met Thr 275 280 285 Val Pro Lys Gln Thr Gln Thr Pro Asp Leu Leu Pro Glu Ala Leu Glu 290 295 300 Ala Gln Val Leu Pro Arg Phe Gln Pro Arg Val Leu Gln Val Gln Ala 305 310 315 320 Gln Val Gln Ser Gln Thr Gln Pro Arg Ile Pro Ser Thr Asp Thr Gln 325 330 335 Val Gln Pro Lys Leu Gln Lys Gln Ala Gln Thr Gln Thr Ser Pro Glu 340 345 350 His Leu Val Leu Gln Gln Lys Gln Val Gln Pro Gln Leu Gln Gln Glu 355 360 365 Ala Glu Pro Gln Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His 370 375 380 Ser Gln Gly Pro Arg Gln Val Gln Leu Gln Gln Glu Ala Glu Pro Leu 385 390 395 400 Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His Ser Gln Pro Pro 405 410 415 Arg Gln Val Gln Leu Gln Leu Gln Lys Gln Val Gln Thr Gln Thr Tyr 420 425 430 Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His 435 440 445 Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln 450 455 460 Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro 465 470 475 480 Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu 485 490 495 Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln 500 505 510 Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val 515 520 525 Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala 530 535 540 Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Ser Ser Asp Ser Arg Ala 545 550 555 560 Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val 565 570 575 Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln 580 585 590 Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe 595 600 605 Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile 610 615 620 Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg 625 630 635 640 Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys 645 650 655 Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg 660 665 670 Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr 675 680 685 Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val 690 695 700 Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu 705 710 715 720 Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala 725 730 735 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 740 745 750 Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser 755 760 765 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 770 775 780 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met Gly Tyr Ile 785 790 795 800 Cys Arg Ile Cys His Lys Phe Tyr His Ser Asn Ser Gly Ala Gln Leu 805 810 815 Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gln Lys Tyr Lys 820 825 830 Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser Arg Arg Cys 835 840 845 Ala Ile Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr Ser Ser Gly 850 855 860 Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys Thr Pro Ser Lys Val 865 870 875 880 Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg Leu 885 890 895 Lys Thr <210> SEQ ID NO 9 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: sequence comprising the exon 14a/exon 15 splice junction <400> SEQUENCE: 9 Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg 1 5 10 15 Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 10 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: excluded sequence from Ciz1 exon 14/exon 15 junction which specifies a Ciz1 b-variant <400> SEQUENCE: 10 Val Glu Glu Glu Leu Cys Lys Gln 1 5 <210> SEQ ID NO 11 <211> LENGTH: 66 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide <400> SEQUENCE: 11 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val Pro 65 <210> SEQ ID NO 12 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long Ciz1 b-variant peptide <400> SEQUENCE: 12 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val 65 <210> SEQ ID NO 13 <211> LENGTH: 72 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long Ciz1 exon 14a peptide <400> SEQUENCE: 13 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Arg Ser Arg Asp 35 40 45 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 60 Ala Tyr Gly Val Asp Phe Leu Val 65 70 <210> SEQ ID NO 14 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA3 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (5)..(5) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 14 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 15 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA6 sequence <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (3)..(5) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (7)..(7) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 15 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 16 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: diagnostic fragment of CIZ1b <400> SEQUENCE: 16 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 17 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: super short CIZ1b peptide (b7) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (8)..(8) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 17 Cys Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 18 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: short CIZ1a peptide (a22) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (23)..(23) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 18 Cys Asp Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 19 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: long CIZ1a peptide (a74) <400> SEQUENCE: 19 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser Arg 35 40 45 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 50 55 60 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 65 70 <210> SEQ ID NO 20 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 17 peptide sequence <400> SEQUENCE: 20 Cys Thr Ser Ser Gly Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys 1 5 10 15 Thr Pro Ser Lys 20 <210> SEQ ID NO 21 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: exon 17 peptide sequence <400> SEQUENCE: 21 Cys Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg 1 5 10 15 Leu Lys Thr <210> SEQ ID NO 22 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: short CIZ1b peptide (b13) <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 22 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 23 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: GLA4 peptide <220> FEATURE: <221> NAME/KEY: MOD_RES <222> LOCATION: (4)..(4) <223> OTHER INFORMATION: carboxylated glutamic acid <220> FEATURE:

<221> NAME/KEY: MOD_RES <222> LOCATION: (14)..(14) <223> OTHER INFORMATION: AMIDATION <400> SEQUENCE: 23 Cys Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 24 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 24 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg 35 <210> SEQ ID NO 25 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 25 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg 35 <210> SEQ ID NO 26 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 26 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg 35 <210> SEQ ID NO 27 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 27 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg 35 <210> SEQ ID NO 28 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 28 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg <210> SEQ ID NO 29 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 29 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg <210> SEQ ID NO 30 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 30 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 31 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 31 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 32 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 32 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 <210> SEQ ID NO 33 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 33 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 34 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 34 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 35 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 35 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 36 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 36 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 37 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 37 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 <210> SEQ ID NO 38 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 38 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 39 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 39 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 40 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 40 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg 20 <210> SEQ ID NO 41 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 41 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg 20 <210> SEQ ID NO 42 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 42 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg 20 <210> SEQ ID NO 43 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 43 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg <210> SEQ ID NO 44 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 44 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg <210> SEQ ID NO 45 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 45 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg <210> SEQ ID NO 46 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 46 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 <210> SEQ ID NO 47 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 47 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 <210> SEQ ID NO 48 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 48 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 49 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 49 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 50 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 50 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 51 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 51 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 52 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 52 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 <210> SEQ ID NO 53 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 53 Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 54 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 54 Asp Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 55 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 55 Glu Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 56 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 56 Glu Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 57 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 57 Glu Ile Glu Val Arg 1 5 <210> SEQ ID NO 58 <211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 58 Ile Glu Val Arg 1 <210> SEQ ID NO 59 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 59 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser 35 <210> SEQ ID NO 60 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 60 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser 35 <210> SEQ ID NO 61 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 61 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser 35 <210> SEQ ID NO 62 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 62 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser 35 <210> SEQ ID NO 63 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 63 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser 35 <210> SEQ ID NO 64 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 64 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser <210> SEQ ID NO 65 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 65 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser <210> SEQ ID NO 66 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 66 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 67 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 67 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 68 <211> LENGTH: 30

<212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 68 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 <210> SEQ ID NO 69 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 69 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 70 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 70 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 71 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 71 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 72 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 72 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 73 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 73 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 <210> SEQ ID NO 74 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 74 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 75 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 75 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 76 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 76 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser 20 <210> SEQ ID NO 77 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 77 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser 20 <210> SEQ ID NO 78 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 78 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser 20 <210> SEQ ID NO 79 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 79 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser <210> SEQ ID NO 80 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 80 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser <210> SEQ ID NO 81 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 81 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser <210> SEQ ID NO 82 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 82 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 <210> SEQ ID NO 83 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 83 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 <210> SEQ ID NO 84 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 84 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 85 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 85 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 86 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 86 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 87 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 87 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 88 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 88 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 <210> SEQ ID NO 89 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 89 Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 90 Glu Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 91 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 91 Glu Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 92 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 92 Glu Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 93 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 93 Ile Glu Val Arg Ser 1 5 <210> SEQ ID NO 94 <211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 94 Glu Val Arg Ser 1 <210> SEQ ID NO 95 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 95 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg 35 40 <210> SEQ ID NO 96 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 96 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg 35 <210> SEQ ID NO 97 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 97 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg 35 <210> SEQ ID NO 98 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 98 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg 35 <210> SEQ ID NO 99 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 99 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg 35 <210> SEQ ID NO 100 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 100 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg 35 <210> SEQ ID NO 101 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 101 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg <210> SEQ ID NO 102 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 102 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg <210> SEQ ID NO 103 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 103 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 104 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 104 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 105 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 105 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 <210> SEQ ID NO 106 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 106 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 107 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 107 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 108 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 108 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 109 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 109 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 110 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 110 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 <210> SEQ ID NO 111 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 111 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 112 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 112 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 113 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 113

Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg 20 <210> SEQ ID NO 114 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 114 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg 20 <210> SEQ ID NO 115 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 115 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg 20 <210> SEQ ID NO 116 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 116 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg <210> SEQ ID NO 117 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 117 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg <210> SEQ ID NO 118 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 118 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg <210> SEQ ID NO 119 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 119 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 <210> SEQ ID NO 120 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 120 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 <210> SEQ ID NO 121 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 121 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 122 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 122 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 123 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 123 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 124 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 124 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 <210> SEQ ID NO 125 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 125 Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 126 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 126 Glu Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 127 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 127 Glu Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 128 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 128 Ile Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 129 <211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 129 Glu Val Arg Ser Arg 1 5 <210> SEQ ID NO 130 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 130 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp 35 40 <210> SEQ ID NO 131 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 131 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp 35 40 <210> SEQ ID NO 132 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 132 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp 35 <210> SEQ ID NO 133 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 133 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp 35 <210> SEQ ID NO 134 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 134 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp 35 <210> SEQ ID NO 135 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 135 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp 35 <210> SEQ ID NO 136 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 136 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp 35 <210> SEQ ID NO 137 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 137 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp <210> SEQ ID NO 138 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 138 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp <210> SEQ ID NO 139 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 139 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 140 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 140 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 141 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 141 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 <210> SEQ ID NO 142 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 142 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 143 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 143 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15

Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 144 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 144 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 145 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 145 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 146 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 146 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 <210> SEQ ID NO 147 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 147 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 148 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 148 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 149 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 149 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp 20 <210> SEQ ID NO 150 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 150 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp 20 <210> SEQ ID NO 151 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 151 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp 20 <210> SEQ ID NO 152 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 152 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp <210> SEQ ID NO 153 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 153 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp <210> SEQ ID NO 154 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 154 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp <210> SEQ ID NO 155 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 155 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 <210> SEQ ID NO 156 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 156 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 <210> SEQ ID NO 157 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 157 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 158 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 158 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 159 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 159 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 160 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 160 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 161 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 161 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 <210> SEQ ID NO 162 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 162 Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 163 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 163 Glu Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 164 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 164 Ile Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 165 <211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 165 Glu Val Arg Ser Arg Asp 1 5 <210> SEQ ID NO 166 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 166 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 167 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 167 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 168 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 168 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile 35 40 <210> SEQ ID NO 169 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 169 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 170 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 170 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 171 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 171 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile 35 <210> SEQ ID NO 172 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 172 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile 35 <210> SEQ ID NO 173 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 173 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile 35

<210> SEQ ID NO 174 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 174 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile <210> SEQ ID NO 175 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 175 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile <210> SEQ ID NO 176 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 176 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 177 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 177 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 178 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 178 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 <210> SEQ ID NO 179 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 179 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 180 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 180 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 181 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 181 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 182 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 182 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 183 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 183 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 <210> SEQ ID NO 184 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 184 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 185 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 185 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 186 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 186 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 187 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 187 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile 20 <210> SEQ ID NO 188 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 188

Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile 20 <210> SEQ ID NO 189 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 189 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile <210> SEQ ID NO 190 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 190 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile <210> SEQ ID NO 191 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 191 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile <210> SEQ ID NO 192 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 192 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 <210> SEQ ID NO 193 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 193 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 <210> SEQ ID NO 194 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 194 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 195 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 195 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 196 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 196 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 197 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 197 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 198 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 198 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 <210> SEQ ID NO 199 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 199 Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 200 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 200 Ile Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 201 <211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 201 Glu Val Arg Ser Arg Asp Ile 1 5 <210> SEQ ID NO 202 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 202 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 203 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 203 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 204 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 204 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30

Ile Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 205 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 205 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser 35 40 <210> SEQ ID NO 206 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 206 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 207 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 207 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 208 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 208 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser 35 <210> SEQ ID NO 209 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 209 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser 35 <210> SEQ ID NO 210 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 210 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser 35 <210> SEQ ID NO 211 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 211 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser <210> SEQ ID NO 212 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 212 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser <210> SEQ ID NO 213 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 213 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 214 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 214 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 215 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 215 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 <210> SEQ ID NO 216 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 216 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 217 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 217 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 218 <211> LENGTH: 27 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 218 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 219 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 219 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 220 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 220 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 <210> SEQ ID NO 221 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 221 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 222 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 222 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 223 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 223 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 224 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 224 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser 20 <210> SEQ ID NO 225 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 225 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser 20 <210> SEQ ID NO 226 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 226 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser <210> SEQ ID NO 227 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 227 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser <210> SEQ ID NO 228 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 228 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser <210> SEQ ID NO 229 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 229 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 <210> SEQ ID NO 230 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 230 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 <210> SEQ ID NO 231 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 231 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 232 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 232 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 233 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 233 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10

<210> SEQ ID NO 234 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 234 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 <210> SEQ ID NO 235 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 235 Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 <210> SEQ ID NO 236 <211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 236 Glu Val Arg Ser Arg Asp Ile Ser 1 5 <210> SEQ ID NO 237 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 237 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 238 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 238 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 239 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 239 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 240 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 240 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 241 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 241 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg 35 40 <210> SEQ ID NO 242 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 242 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 243 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 243 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 244 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 244 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg 35 <210> SEQ ID NO 245 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 245 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg 35 <210> SEQ ID NO 246 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 246 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg 35 <210> SEQ ID NO 247 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 247

Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg <210> SEQ ID NO 248 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 248 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg <210> SEQ ID NO 249 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 249 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 250 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 250 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 251 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 251 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 <210> SEQ ID NO 252 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 252 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 253 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 253 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 254 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 254 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 255 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 255 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 256 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 256 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 <210> SEQ ID NO 257 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 257 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 258 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 258 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 259 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 259 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 260 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 260 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg 20 <210> SEQ ID NO 261 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 261 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg 20 <210> SEQ ID NO 262

<211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 262 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg <210> SEQ ID NO 263 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 263 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg <210> SEQ ID NO 264 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 264 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg <210> SEQ ID NO 265 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 265 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 <210> SEQ ID NO 266 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 266 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 <210> SEQ ID NO 267 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 267 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 268 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 268 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 269 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 269 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 270 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 270 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 271 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 271 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 <210> SEQ ID NO 272 <211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 272 Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 <210> SEQ ID NO 273 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 273 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 45 <210> SEQ ID NO 274 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 274 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 275 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 275 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 276 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 276 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 277 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 277 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15

Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 278 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 278 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu 35 40 <210> SEQ ID NO 279 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 279 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 280 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 280 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 281 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 281 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu 35 <210> SEQ ID NO 282 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 282 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu 35 <210> SEQ ID NO 283 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 283 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu 35 <210> SEQ ID NO 284 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 284 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu <210> SEQ ID NO 285 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 285 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu <210> SEQ ID NO 286 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 286 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 287 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 287 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 288 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 288 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 <210> SEQ ID NO 289 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 289 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 290 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 290 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25

<210> SEQ ID NO 291 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 291 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 292 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 292 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 293 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 293 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 <210> SEQ ID NO 294 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 294 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 295 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 295 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 296 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 296 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 297 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 297 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu 20 <210> SEQ ID NO 298 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 298 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu 20 <210> SEQ ID NO 299 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 299 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu <210> SEQ ID NO 300 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 300 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu <210> SEQ ID NO 301 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 301 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu <210> SEQ ID NO 302 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 302 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 <210> SEQ ID NO 303 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 303 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 <210> SEQ ID NO 304 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 304 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 305 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 305 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 306 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 306 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu

1 5 10 <210> SEQ ID NO 307 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 307 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 308 <211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 308 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 <210> SEQ ID NO 309 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 309 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 45 <210> SEQ ID NO 310 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 310 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 45 <210> SEQ ID NO 311 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 311 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 312 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 312 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 313 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 313 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 314 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 314 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 315 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 315 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu 35 40 <210> SEQ ID NO 316 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 316 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 317 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 317 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 318 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 318 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu 35 <210> SEQ ID NO 319 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 319 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu 35

<210> SEQ ID NO 320 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 320 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu 35 <210> SEQ ID NO 321 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 321 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu <210> SEQ ID NO 322 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 322 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu <210> SEQ ID NO 323 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 323 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 324 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 324 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 325 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 325 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 <210> SEQ ID NO 326 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 326 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 327 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 327 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 328 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 328 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 329 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 329 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 330 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 330 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 <210> SEQ ID NO 331 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 331 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 332 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 332 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 333 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 333 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 334 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon

14b/exon 15 junction <400> SEQUENCE: 334 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu 20 <210> SEQ ID NO 335 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 335 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu 20 <210> SEQ ID NO 336 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 336 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu <210> SEQ ID NO 337 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 337 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu <210> SEQ ID NO 338 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 338 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu <210> SEQ ID NO 339 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 339 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 <210> SEQ ID NO 340 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 340 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 <210> SEQ ID NO 341 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 341 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 342 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 342 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 343 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 343 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 344 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 344 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 <210> SEQ ID NO 345 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 345 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 346 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 346 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 347 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 347 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 45 <210> SEQ ID NO 348 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 348 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 349 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 349 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu

1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 350 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 350 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 351 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 351 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 352 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 352 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp 35 40 <210> SEQ ID NO 353 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 353 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 354 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 354 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 355 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 355 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp 35 <210> SEQ ID NO 356 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 356 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp 35 <210> SEQ ID NO 357 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 357 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp 35 <210> SEQ ID NO 358 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 358 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp <210> SEQ ID NO 359 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 359 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp <210> SEQ ID NO 360 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 360 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 361 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 361 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 362 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 362

Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 <210> SEQ ID NO 363 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 363 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 364 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 364 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 365 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 365 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 366 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 366 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 367 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 367 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 <210> SEQ ID NO 368 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 368 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 369 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 369 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 370 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 370 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 371 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 371 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp 20 <210> SEQ ID NO 372 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 372 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp 20 <210> SEQ ID NO 373 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 373 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp <210> SEQ ID NO 374 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 374 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp <210> SEQ ID NO 375 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 375 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp <210> SEQ ID NO 376 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 376 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 <210> SEQ ID NO 377 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 377 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15

<210> SEQ ID NO 378 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 378 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 379 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 379 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 380 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 380 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 <210> SEQ ID NO 381 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 381 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 382 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 382 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 383 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 383 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 384 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 384 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 <210> SEQ ID NO 385 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 385 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 386 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 386 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 387 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 387 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 388 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 388 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 389 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 389 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys 35 40 <210> SEQ ID NO 390 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 390 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 391 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 391 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 392 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 392 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys 35 <210> SEQ ID NO 393 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 393 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys 35 <210> SEQ ID NO 394 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 394 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys 35 <210> SEQ ID NO 395 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 395 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys <210> SEQ ID NO 396 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 396 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys <210> SEQ ID NO 397 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 397 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 398 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 398 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 399 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 399 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 <210> SEQ ID NO 400 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 400 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 401 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 401 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 402 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 402 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 403 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 403 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 404 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 404 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 <210> SEQ ID NO 405 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 405 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 406 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 406 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 407 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 407 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 408 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 408 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys 20 <210> SEQ ID NO 409 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 409 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys 20 <210> SEQ ID NO 410 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 410 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys <210> SEQ ID NO 411 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 411 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys <210> SEQ ID NO 412 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 412 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys <210> SEQ ID NO 413 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 413 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 <210> SEQ ID NO 414 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 414 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 <210> SEQ ID NO 415 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 415 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 <210> SEQ ID NO 416 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 416 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 <210> SEQ ID NO 417 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 417 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly <210> SEQ ID NO 418 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 418 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 419 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 419 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 420 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 420 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 421 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 421 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 <210> SEQ ID NO 422 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 422 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 423 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 423 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 424 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 424 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 425 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 425 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 426 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 426 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly 35 40 <210> SEQ ID NO 427 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 427 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 428 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 428 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 429 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 429 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly 35 <210> SEQ ID NO 430 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 430 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly 35 <210> SEQ ID NO 431 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 431 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly 35 <210> SEQ ID NO 432 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 432 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30

Lys Gly <210> SEQ ID NO 433 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 433 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly <210> SEQ ID NO 434 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 434 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 435 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 435 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 436 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 436 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 <210> SEQ ID NO 437 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 437 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 438 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 438 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 439 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 439 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 440 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 440 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 441 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 441 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 <210> SEQ ID NO 442 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 442 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 443 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 443 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 444 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 444 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 445 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 445 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly 20 <210> SEQ ID NO 446 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 446 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly 20 <210> SEQ ID NO 447 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 447 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly <210> SEQ ID NO 448 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 448 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly <210> SEQ ID NO 449 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 449 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly <210> SEQ ID NO 450 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 450 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 <210> SEQ ID NO 451 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 451 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 <210> SEQ ID NO 452 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 452 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 <210> SEQ ID NO 453 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 453 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser 50 <210> SEQ ID NO 454 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 454 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser <210> SEQ ID NO 455 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 455 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 456 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 456 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 457 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 457 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 458 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 458 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 <210> SEQ ID NO 459 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 459 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 460 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 460 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 461 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 461 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 462 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 462 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 463 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 463 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser 35 40 <210> SEQ ID NO 464 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 464 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 465 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 465 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 466 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 466 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser 35 <210> SEQ ID NO 467 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 467 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser 35 <210> SEQ ID NO 468 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 468 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser 35 <210> SEQ ID NO 469 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 469 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser <210> SEQ ID NO 470 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 470 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser <210> SEQ ID NO 471 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 471 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 472 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 472 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 473 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 473 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 <210> SEQ ID NO 474 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon

14b/exon 15 junction <400> SEQUENCE: 474 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 475 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 475 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 476 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 476 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 477 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 477 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 478 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 478 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 <210> SEQ ID NO 479 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 479 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 480 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 480 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 481 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 481 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 482 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 482 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser 20 <210> SEQ ID NO 483 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 483 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser 20 <210> SEQ ID NO 484 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 484 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser <210> SEQ ID NO 485 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 485 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser <210> SEQ ID NO 486 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 486 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser <210> SEQ ID NO 487 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 487 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 <210> SEQ ID NO 488 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 488 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 <210> SEQ ID NO 489 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 489 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val

1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu 50 <210> SEQ ID NO 490 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 490 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu 50 <210> SEQ ID NO 491 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 491 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu <210> SEQ ID NO 492 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 492 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 493 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 493 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 494 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 494 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 495 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 495 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 <210> SEQ ID NO 496 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 496 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 497 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 497 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 498 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 498 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 499 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 499 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 500 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 500 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu 35 40 <210> SEQ ID NO 501 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 501 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg

20 25 30 Glu Glu Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 502 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 502 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 503 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 503 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu 35 <210> SEQ ID NO 504 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 504 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu 35 <210> SEQ ID NO 505 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 505 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu 35 <210> SEQ ID NO 506 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 506 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu <210> SEQ ID NO 507 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 507 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu <210> SEQ ID NO 508 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 508 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 509 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 509 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 510 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 510 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 <210> SEQ ID NO 511 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 511 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 512 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 512 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 513 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 513 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 514 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 514 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 515 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 515 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 <210> SEQ ID NO 516 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 516 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 517 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 517 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 518 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 518 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 519 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 519 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu 20 <210> SEQ ID NO 520 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 520 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu 20 <210> SEQ ID NO 521 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 521 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu <210> SEQ ID NO 522 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 522 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu <210> SEQ ID NO 523 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 523 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu <210> SEQ ID NO 524 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 524 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 <210> SEQ ID NO 525 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 525 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr 50 <210> SEQ ID NO 526 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 526 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr 50 <210> SEQ ID NO 527 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 527 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr 50 <210> SEQ ID NO 528 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 528 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr <210> SEQ ID NO 529 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 529 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 530 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 530 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 531 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 531 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 532 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 532 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 <210> SEQ ID NO 533 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 533 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 534 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 534 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 535 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 535 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 536 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 536 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 537 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 537 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr 35 40 <210> SEQ ID NO 538 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 538 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 539 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 539 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 540 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 540 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr 35 <210> SEQ ID NO 541 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 541 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30

Gly Ser Glu Thr 35 <210> SEQ ID NO 542 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 542 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr 35 <210> SEQ ID NO 543 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 543 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr <210> SEQ ID NO 544 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 544 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr <210> SEQ ID NO 545 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 545 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 546 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 546 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 547 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 547 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 <210> SEQ ID NO 548 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 548 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 549 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 549 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 550 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 550 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 551 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 551 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 552 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 552 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 <210> SEQ ID NO 553 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 553 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 554 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 554 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 555 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 555 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 556

<211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 556 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr 20 <210> SEQ ID NO 557 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 557 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr 20 <210> SEQ ID NO 558 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 558 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr <210> SEQ ID NO 559 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 559 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr <210> SEQ ID NO 560 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 560 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr <210> SEQ ID NO 561 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 561 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr 50 <210> SEQ ID NO 562 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 562 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr 50 <210> SEQ ID NO 563 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 563 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr 50 <210> SEQ ID NO 564 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 564 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr 50 <210> SEQ ID NO 565 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 565 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr <210> SEQ ID NO 566 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 566 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 567 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 567 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 568 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 568 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30

Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 569 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 569 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 <210> SEQ ID NO 570 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 570 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 571 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 571 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 572 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 572 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 573 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 573 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 574 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 574 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 <210> SEQ ID NO 575 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 575 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 576 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 576 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 577 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 577 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr 35 <210> SEQ ID NO 578 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 578 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr 35 <210> SEQ ID NO 579 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 579 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr 35 <210> SEQ ID NO 580 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 580 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr <210> SEQ ID NO 581 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 581 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr <210> SEQ ID NO 582 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 582 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 583 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 583 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 584 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 584 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 <210> SEQ ID NO 585 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 585 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 586 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 586 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 587 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 587 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 588 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 588 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 589 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 589 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 <210> SEQ ID NO 590 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 590 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 591 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 591 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 592 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 592 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 593 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 593 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr 20 <210> SEQ ID NO 594 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 594 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr 20 <210> SEQ ID NO 595 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 595 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr <210> SEQ ID NO 596 <211> LENGTH: 18 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 596 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr <210> SEQ ID NO 597 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 597 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser 50 <210> SEQ ID NO 598 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 598 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser 50 <210> SEQ ID NO 599 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 599 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser 50 <210> SEQ ID NO 600 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 600 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser 50 <210> SEQ ID NO 601 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 601 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser 50 <210> SEQ ID NO 602 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 602 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser <210> SEQ ID NO 603 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 603 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 604 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 604 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 605 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 605 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 606 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 606 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 <210> SEQ ID NO 607 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 607 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 608 <211> LENGTH: 43

<212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 608 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 609 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 609 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 610 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 610 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 611 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 611 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 <210> SEQ ID NO 612 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 612 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 613 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 613 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 614 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 614 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser 35 <210> SEQ ID NO 615 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 615 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser 35 <210> SEQ ID NO 616 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 616 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser 35 <210> SEQ ID NO 617 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 617 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser <210> SEQ ID NO 618 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 618 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser <210> SEQ ID NO 619 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 619 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 620 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 620 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 621

<211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 621 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 <210> SEQ ID NO 622 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 622 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 623 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 623 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 624 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 624 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 625 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 625 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 626 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 626 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 <210> SEQ ID NO 627 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 627 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 628 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 628 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 629 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 629 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 630 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 630 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser 20 <210> SEQ ID NO 631 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 631 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser 20 <210> SEQ ID NO 632 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 632 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser <210> SEQ ID NO 633 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 633 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro 50 55 <210> SEQ ID NO 634 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 634 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro 50 <210> SEQ ID NO 635 <211> LENGTH: 53 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 635 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro 50 <210> SEQ ID NO 636 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 636 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro 50 <210> SEQ ID NO 637 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 637 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro 50 <210> SEQ ID NO 638 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 638 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro 50 <210> SEQ ID NO 639 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 639 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro <210> SEQ ID NO 640 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 640 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 641 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 641 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 642 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 642 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 643 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 643 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 <210> SEQ ID NO 644 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 644 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 645 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 645 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 646 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 646 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 647

<211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 647 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 648 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 648 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 <210> SEQ ID NO 649 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 649 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 650 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 650 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 651 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 651 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro 35 <210> SEQ ID NO 652 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 652 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro 35 <210> SEQ ID NO 653 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 653 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro 35 <210> SEQ ID NO 654 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 654 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro <210> SEQ ID NO 655 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 655 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro <210> SEQ ID NO 656 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 656 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 657 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 657 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 658 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 658 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 <210> SEQ ID NO 659 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 659 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 660 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon

14b/exon 15 junction <400> SEQUENCE: 660 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 661 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 661 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 662 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 662 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 663 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 663 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 <210> SEQ ID NO 664 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 664 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 665 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 665 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 666 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 666 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 667 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 667 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro 20 <210> SEQ ID NO 668 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 668 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro 20 <210> SEQ ID NO 669 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 669 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn 50 55 <210> SEQ ID NO 670 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 670 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn 50 55 <210> SEQ ID NO 671 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 671 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn 50 <210> SEQ ID NO 672 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 672 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn 50 <210> SEQ ID NO 673 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 673 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15

Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn 50 <210> SEQ ID NO 674 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 674 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn 50 <210> SEQ ID NO 675 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 675 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn 50 <210> SEQ ID NO 676 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 676 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn <210> SEQ ID NO 677 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 677 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 678 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 678 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 679 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 679 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 680 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 680 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 <210> SEQ ID NO 681 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 681 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 682 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 682 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 683 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 683 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 684 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 684 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 685 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 685 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15

Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 <210> SEQ ID NO 686 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 686 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 687 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 687 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 688 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 688 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn 35 <210> SEQ ID NO 689 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 689 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn 35 <210> SEQ ID NO 690 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 690 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn 35 <210> SEQ ID NO 691 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 691 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn <210> SEQ ID NO 692 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 692 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn <210> SEQ ID NO 693 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 693 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 694 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 694 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 695 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 695 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 <210> SEQ ID NO 696 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 696 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 697 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 697 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 698 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 698 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 699 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence

<220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 699 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 700 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 700 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 <210> SEQ ID NO 701 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 701 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 702 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 702 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 703 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 703 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 704 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 704 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn 20 <210> SEQ ID NO 705 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 705 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 706 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 706 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 707 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 707 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr 50 55 <210> SEQ ID NO 708 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 708 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr 50 <210> SEQ ID NO 709 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 709 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr 50 <210> SEQ ID NO 710 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 710 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr 50 <210> SEQ ID NO 711 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 711 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30

Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr 50 <210> SEQ ID NO 712 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 712 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr 50 <210> SEQ ID NO 713 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 713 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr <210> SEQ ID NO 714 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 714 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 715 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 715 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 716 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 716 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 717 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 717 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 <210> SEQ ID NO 718 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 718 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 719 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 719 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 720 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 720 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 721 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 721 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 722 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 722 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 <210> SEQ ID NO 723 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 723 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr 35

<210> SEQ ID NO 724 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 724 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr 35 <210> SEQ ID NO 725 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 725 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr 35 <210> SEQ ID NO 726 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 726 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr 35 <210> SEQ ID NO 727 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 727 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr 35 <210> SEQ ID NO 728 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 728 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr <210> SEQ ID NO 729 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 729 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr <210> SEQ ID NO 730 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 730 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 731 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 731 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 732 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 732 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 <210> SEQ ID NO 733 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 733 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 734 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 734 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 735 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 735 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 736 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 736 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 737 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 737 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15

Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 <210> SEQ ID NO 738 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 738 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 739 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 739 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 740 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 740 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr 20 <210> SEQ ID NO 741 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 741 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 742 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 742 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 743 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 743 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 744 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 744 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala 50 55 <210> SEQ ID NO 745 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 745 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala 50 <210> SEQ ID NO 746 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 746 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala 50 <210> SEQ ID NO 747 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 747 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala 50 <210> SEQ ID NO 748 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 748 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala 50 <210> SEQ ID NO 749 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 749 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15

Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala 50 <210> SEQ ID NO 750 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 750 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala <210> SEQ ID NO 751 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 751 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 752 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 752 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 753 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 753 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 754 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 754 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 <210> SEQ ID NO 755 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 755 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 756 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 756 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 757 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 757 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 758 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 758 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 759 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 759 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 <210> SEQ ID NO 760 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 760 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala 35 <210> SEQ ID NO 761 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 761 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala 35

<210> SEQ ID NO 762 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 762 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala 35 <210> SEQ ID NO 763 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 763 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala 35 <210> SEQ ID NO 764 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 764 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala 35 <210> SEQ ID NO 765 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 765 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala <210> SEQ ID NO 766 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 766 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala <210> SEQ ID NO 767 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 767 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 768 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 768 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 769 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 769 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 <210> SEQ ID NO 770 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 770 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 771 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 771 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 772 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 772 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 773 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 773 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 774 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 774 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 <210> SEQ ID NO 775 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 775 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala 20

<210> SEQ ID NO 776 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 776 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala 20 <210> SEQ ID NO 777 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 777 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 778 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 778 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 779 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 779 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 780 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 780 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 781 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 781 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr 50 55 <210> SEQ ID NO 782 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 782 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr 50 <210> SEQ ID NO 783 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 783 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr 50 <210> SEQ ID NO 784 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 784 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr 50 <210> SEQ ID NO 785 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 785 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr 50 <210> SEQ ID NO 786 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 786 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr 50 <210> SEQ ID NO 787 <211> LENGTH: 49 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 787 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr <210> SEQ ID NO 788 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 788 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 789 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 789 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 790 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 790 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 791 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 791 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 <210> SEQ ID NO 792 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 792 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 793 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 793 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 794 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 794 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 795 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 795 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 796 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 796 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 <210> SEQ ID NO 797 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 797 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 798 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 798 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 799 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 799 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15

Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr 35 <210> SEQ ID NO 800 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 800 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr 35 <210> SEQ ID NO 801 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 801 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr 35 <210> SEQ ID NO 802 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 802 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr <210> SEQ ID NO 803 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 803 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr <210> SEQ ID NO 804 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 804 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 805 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 805 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 806 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 806 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 <210> SEQ ID NO 807 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 807 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 808 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 808 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 809 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 809 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 810 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 810 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 811 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 811 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 <210> SEQ ID NO 812 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 812 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr 20 <210> SEQ ID NO 813 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 813 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15

Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 60 <210> SEQ ID NO 814 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 814 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 815 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 815 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 816 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 816 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 817 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 817 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 818 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 818 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly 50 55 <210> SEQ ID NO 819 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 819 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly 50 <210> SEQ ID NO 820 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 820 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly 50 <210> SEQ ID NO 821 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 821 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly 50 <210> SEQ ID NO 822 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 822 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly 50 <210> SEQ ID NO 823 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 823 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly 50 <210> SEQ ID NO 824 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 824 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu

1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly <210> SEQ ID NO 825 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 825 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 826 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 826 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 827 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 827 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 828 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 828 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 <210> SEQ ID NO 829 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 829 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 830 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 830 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 831 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 831 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 832 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 832 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 833 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 833 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 <210> SEQ ID NO 834 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 834 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 835 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 835 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 836 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 836 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly 35 <210> SEQ ID NO 837

<211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 837 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly 35 <210> SEQ ID NO 838 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 838 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly 35 <210> SEQ ID NO 839 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 839 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly <210> SEQ ID NO 840 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 840 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly <210> SEQ ID NO 841 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 841 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 842 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 842 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 843 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 843 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 <210> SEQ ID NO 844 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 844 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 845 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 845 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 846 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 846 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 847 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 847 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 848 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 848 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 <210> SEQ ID NO 849 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 849 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 60 <210> SEQ ID NO 850 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 850 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30

Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 60 <210> SEQ ID NO 851 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 851 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 852 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 852 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 853 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 853 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 854 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 854 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 855 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 855 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val 50 55 <210> SEQ ID NO 856 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 856 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val 50 <210> SEQ ID NO 857 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 857 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val 50 <210> SEQ ID NO 858 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 858 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val 50 <210> SEQ ID NO 859 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 859 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val 50 <210> SEQ ID NO 860 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 860 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val 50 <210> SEQ ID NO 861 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 861 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15

Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val <210> SEQ ID NO 862 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 862 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 863 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 863 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 864 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 864 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 865 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 865 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 <210> SEQ ID NO 866 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 866 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 867 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 867 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 868 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 868 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 869 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 869 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 870 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 870 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val 35 40 <210> SEQ ID NO 871 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 871 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 872 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 872 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 873 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 873 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val 35 <210> SEQ ID NO 874 <211> LENGTH: 36 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 874 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val 35 <210> SEQ ID NO 875 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 875 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val 35 <210> SEQ ID NO 876 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 876 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val <210> SEQ ID NO 877 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 877 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val <210> SEQ ID NO 878 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 878 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 879 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 879 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 880 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 880 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 <210> SEQ ID NO 881 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 881 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 882 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 882 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 883 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 883 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 884 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 884 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 <210> SEQ ID NO 885 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 885 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 886 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 886 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 887 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 887 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys

1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 60 <210> SEQ ID NO 888 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 888 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 889 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 889 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 890 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 890 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 891 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 891 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 892 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 892 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp 50 55 <210> SEQ ID NO 893 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 893 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp 50 <210> SEQ ID NO 894 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 894 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp 50 <210> SEQ ID NO 895 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 895 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp 50 <210> SEQ ID NO 896 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 896 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp 50 <210> SEQ ID NO 897 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 897 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp 50 <210> SEQ ID NO 898 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 898

Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp <210> SEQ ID NO 899 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 899 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 900 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 900 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 901 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 901 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 902 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 902 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 <210> SEQ ID NO 903 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 903 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 904 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 904 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 905 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 905 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 906 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 906 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 907 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 907 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp 35 40 <210> SEQ ID NO 908 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 908 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp 35 <210> SEQ ID NO 909 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 909 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp 35 <210> SEQ ID NO 910 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 910 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp 35

<210> SEQ ID NO 911 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 911 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp 35 <210> SEQ ID NO 912 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 912 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp 35 <210> SEQ ID NO 913 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 913 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp <210> SEQ ID NO 914 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 914 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp <210> SEQ ID NO 915 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 915 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 916 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 916 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 917 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 917 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 <210> SEQ ID NO 918 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 918 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 919 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 919 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 920 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 920 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 <210> SEQ ID NO 921 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 921 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 922 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 922 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 923 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 923 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 924

<211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 924 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 60 <210> SEQ ID NO 925 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 925 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 926 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 926 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 927 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 927 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 928 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 928 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 929 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 929 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe 50 55 <210> SEQ ID NO 930 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 930 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe 50 <210> SEQ ID NO 931 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 931 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe 50 <210> SEQ ID NO 932 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 932 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe 50 <210> SEQ ID NO 933 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 933 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe 50 <210> SEQ ID NO 934 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 934 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe 50

<210> SEQ ID NO 935 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 935 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe <210> SEQ ID NO 936 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 936 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 937 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 937 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 938 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 938 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 939 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 939 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 <210> SEQ ID NO 940 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 940 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 941 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 941 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 942 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 942 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 943 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 943 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 944 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 944 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe 35 40 <210> SEQ ID NO 945 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 945 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 946 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 946 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 947 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 947 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe 35 <210> SEQ ID NO 948 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 948 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe 35 <210> SEQ ID NO 949 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 949 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe 35 <210> SEQ ID NO 950 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 950 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe <210> SEQ ID NO 951 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 951 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe <210> SEQ ID NO 952 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 952 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 953 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 953 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 954 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 954 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 <210> SEQ ID NO 955 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 955 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 <210> SEQ ID NO 956 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 956 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 <210> SEQ ID NO 957 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 957 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 958 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 958 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 959 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 959 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 960 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 960 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 961 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 961 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 <210> SEQ ID NO 962 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 962 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 963 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 963 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 964 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 964 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 965 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 965 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 966 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 966 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu 50 55 <210> SEQ ID NO 967 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 967 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu 50 <210> SEQ ID NO 968 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 968 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu 50 <210> SEQ ID NO 969 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 969 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu 50 <210> SEQ ID NO 970 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 970 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu 50 <210> SEQ ID NO 971 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:

<223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 971 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe Leu 50 <210> SEQ ID NO 972 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 972 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu <210> SEQ ID NO 973 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 973 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 974 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 974 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 975 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 975 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 976 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 976 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 <210> SEQ ID NO 977 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 977 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 978 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 978 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 979 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 979 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 980 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 980 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 981 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 981 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu 35 40 <210> SEQ ID NO 982 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 982 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu 35 <210> SEQ ID NO 983 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 983 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15

Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu 35 <210> SEQ ID NO 984 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 984 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu 35 <210> SEQ ID NO 985 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 985 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu 35 <210> SEQ ID NO 986 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 986 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu 35 <210> SEQ ID NO 987 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 987 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu <210> SEQ ID NO 988 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 988 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu <210> SEQ ID NO 989 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 989 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 990 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 990 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 991 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 991 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 <210> SEQ ID NO 992 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 992 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 <210> SEQ ID NO 993 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 993 Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val 1 5 10 15 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 20 25 30 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 35 40 45 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 50 55 60 Val 65 <210> SEQ ID NO 994 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 994 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 995 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 995 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 996 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:

<223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 996 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 997 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 997 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 998 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 998 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 <210> SEQ ID NO 999 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 999 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1000 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1000 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1001 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1001 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1002 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1002 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1003 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1003 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu Val 50 55 <210> SEQ ID NO 1004 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1004 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu Val 50 <210> SEQ ID NO 1005 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1005 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu Val 50 <210> SEQ ID NO 1006 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1006 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu Val 50 <210> SEQ ID NO 1007 <211> LENGTH: 51 <212> TYPE: PRT

<213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1007 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45 Phe Leu Val 50 <210> SEQ ID NO 1008 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1008 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu Val 50 <210> SEQ ID NO 1009 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1009 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 Val <210> SEQ ID NO 1010 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1010 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1011 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1011 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1012 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1012 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1013 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1013 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 <210> SEQ ID NO 1014 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1014 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1015 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1015 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1016 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1016 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1017 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1017 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1018 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1018 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu Val 35 40 <210> SEQ ID NO 1019 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction

<400> SEQUENCE: 1019 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu Val 35 <210> SEQ ID NO 1020 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1020 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu Val 35 <210> SEQ ID NO 1021 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1021 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu Val 35 <210> SEQ ID NO 1022 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1022 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu Val 35 <210> SEQ ID NO 1023 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1023 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu Val 35 <210> SEQ ID NO 1024 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1024 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu Val <210> SEQ ID NO 1025 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1025 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 Val <210> SEQ ID NO 1026 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1026 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1027 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1027 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1028 <211> LENGTH: 30 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1028 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 <210> SEQ ID NO 1029 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1029 Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly 1 5 10 15 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 20 25 30 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 35 40 45 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 50 55 60 Pro 65 <210> SEQ ID NO 1030 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1030 Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys 1 5 10 15 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 20 25 30 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 35 40 45 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1031 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1031 Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe 1 5 10 15 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 20 25 30 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 35 40 45 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro

50 55 60 <210> SEQ ID NO 1032 <211> LENGTH: 62 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1032 Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu 1 5 10 15 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 20 25 30 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 35 40 45 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1033 <211> LENGTH: 61 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1033 Asp Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly 1 5 10 15 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 20 25 30 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 35 40 45 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1034 <211> LENGTH: 60 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1034 Glu Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp 1 5 10 15 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 20 25 30 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 35 40 45 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 60 <210> SEQ ID NO 1035 <211> LENGTH: 59 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1035 Asp His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu 1 5 10 15 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 20 25 30 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 35 40 45 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1036 <211> LENGTH: 58 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1036 His Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu 1 5 10 15 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 20 25 30 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 35 40 45 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1037 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1037 Phe Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu 1 5 10 15 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 20 25 30 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 35 40 45 Ala Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1038 <211> LENGTH: 56 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1038 Ile Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu 1 5 10 15 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 20 25 30 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 35 40 45 Tyr Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1039 <211> LENGTH: 55 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1039 Thr Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu 1 5 10 15 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 20 25 30 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 35 40 45 Gly Val Asp Phe Leu Val Pro 50 55 <210> SEQ ID NO 1040 <211> LENGTH: 54 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1040 Val Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp 1 5 10 15 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 20 25 30 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 35 40 45 Val Asp Phe Leu Val Pro 50 <210> SEQ ID NO 1041 <211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1041 Asp Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp 1 5 10 15 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 20 25 30 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 35 40 45 Asp Phe Leu Val Pro 50 <210> SEQ ID NO 1042 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1042 Ala Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu 1 5 10 15 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 20 25 30 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 35 40 45

Phe Leu Val Pro 50 <210> SEQ ID NO 1043 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1043 Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 1 5 10 15 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 20 25 30 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 35 40 45 Leu Val Pro 50 <210> SEQ ID NO 1044 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1044 Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu 1 5 10 15 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 20 25 30 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 35 40 45 Val Pro 50 <210> SEQ ID NO 1045 <211> LENGTH: 49 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1045 Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu 1 5 10 15 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 20 25 30 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 35 40 45 Pro <210> SEQ ID NO 1046 <211> LENGTH: 48 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1046 Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu 1 5 10 15 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 20 25 30 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1047 <211> LENGTH: 47 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1047 Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile 1 5 10 15 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 20 25 30 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1048 <211> LENGTH: 46 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1048 Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu 1 5 10 15 Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr 20 25 30 Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1049 <211> LENGTH: 45 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1049 Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val 1 5 10 15 Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr 20 25 30 Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 45 <210> SEQ ID NO 1050 <211> LENGTH: 44 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1050 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg 1 5 10 15 Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser 20 25 30 Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1051 <211> LENGTH: 43 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1051 Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser 1 5 10 15 Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 20 25 30 Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1052 <211> LENGTH: 42 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1052 Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg 1 5 10 15 Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn 20 25 30 Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1053 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1053 Glu Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp 1 5 10 15 Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr 20 25 30 Ala Tyr Gly Val Asp Phe Leu Val Pro 35 40 <210> SEQ ID NO 1054 <211> LENGTH: 40 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1054 Glu Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile 1 5 10 15 Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala 20 25 30 Tyr Gly Val Asp Phe Leu Val Pro 35 40

<210> SEQ ID NO 1055 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1055 Asp Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser 1 5 10 15 Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr 20 25 30 Gly Val Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1056 <211> LENGTH: 38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1056 Asp Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg 1 5 10 15 Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly 20 25 30 Val Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1057 <211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1057 Glu Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu 1 5 10 15 Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val 20 25 30 Asp Phe Leu Val Pro 35 <210> SEQ ID NO 1058 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1058 Asp Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu 1 5 10 15 Trp Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp 20 25 30 Phe Leu Val Pro 35 <210> SEQ ID NO 1059 <211> LENGTH: 35 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1059 Glu Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp 1 5 10 15 Lys Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe 20 25 30 Leu Val Pro 35 <210> SEQ ID NO 1060 <211> LENGTH: 34 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1060 Glu Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys 1 5 10 15 Gly Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu 20 25 30 Val Pro <210> SEQ ID NO 1061 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1061 Glu Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly 1 5 10 15 Ser Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val 20 25 30 Pro <210> SEQ ID NO 1062 <211> LENGTH: 32 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1062 Ile Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser 1 5 10 15 Glu Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 20 25 30 <210> SEQ ID NO 1063 <211> LENGTH: 31 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Ciz1 b-variant peptide comprising an exon 14b/exon 15 junction <400> SEQUENCE: 1063 Glu Val Arg Ser Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu 1 5 10 15 Thr Tyr Ser Pro Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro 20 25 30

Claims

1-7. (canceled)

8. A method of detecting cancer in a subject which comprises detecting a Ciz1 b-variant peptide in a sample from the subject, wherein the presence of Ciz1 b-variant peptide in the sample indicates that the subject has cancer and wherein the method comprises the step of capturing a fibrinogen/Ciz1 b-variant peptide complex from the sample.

9. A method of detecting cancer in a subject which comprises detecting a Ciz1 b-variant peptide in a sample from the subject, wherein the presence of Ciz1 b-variant peptide in the sample indicates that the subject has cancer and wherein the Ciz1 b-variant peptide is the sequence shown as SEQ ID NO: 11 or a fragment thereof which comprises EVR as shown in positions 36 to 38 of SEQ ID NO: 11.

10. A method according to claim 8 which comprises the following steps: (a) capturing a fibrinogen/Ciz1 b-variant complex using a fibrinogen capture agent; and (b) detecting Ciz1 b-variant using a Ciz1 b-variant detection agent; or (a) capturing a fibrinogen/Ciz1 b-variant complex using a Ciz1 b-variant capture agent; and (b) detecting fibrinogen using a fibrinogen detection agent.

11. The method according to claim 10 wherein the Ciz1 b-variant capture agent is an antibody or a fragment thereof, or a non-protein scaffold which specifically binds Ciz1 b-variant.

12. The method according to claim 10 wherein the Ciz1 b-variant capture agent is an antibody which specifically binds Ciz1 b-variant.

13. The method according to claim 8 wherein the step of detecting the Ciz1 b-variant peptide or fibrinogen employs antibody-based arrays, enzyme linked immunosorbent assays (ELISA), non-antibody protein scaffolds, radioimmuno-assay (RIA), western blotting, aptamers or mass spectrometry.

14. The method according to claim 8, further comprising the step of releasing a Ciz1 b-variant peptide and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment of the sample.

15. The method according to claim 14 wherein the Ciz1 b-variant peptide and/or fibrinogen/Ciz1 b-variant complex is released from the exosomal compartment by detergent treatment.

16. The method according to claim 14, further comprising the step of enriching the exosomal fraction from the sample.

17. The method according to claim 16, wherein the step of enriching the exosomal fraction comprises ultracentrifugation, ultrafiltration, continuous flow electrophoresis, chromatography, precipitation or cross-flow ultrafiltration.

18. The method according to claim 10 wherein the cancer is selected from lung, lymphoma, kidney, breast, liver, bladder, ovarian or thyroid cancer.

19. The method according to claim 18 wherein the cancer is lung cancer.

20. A method of treating a subject with cancer comprising administering to the subject a cancer therapeutic; wherein the subject has been identified as having cancer by the method as defined in claim 10.

21-23. (canceled)

24. A method of detecting a Ciz1 b-variant in a sample which comprises the step of releasing a Ciz1 b-variant and/or a fibrinogen/Ciz1 b-variant complex from an exosomal compartment of the sample by treating the sample with detergent and detecting if the Ciz1 b-variant is present in the sample.

25. The method according to claim 24 wherein the Ciz1 b-variant is in a complex with fibrinogen.

26. The method according to claim 24 which comprises the step of enriching the exosomal fraction from the sample prior to releasing the Ciz1 b-variant.

27. The method according to claim 26, wherein the step of enriching the exosomal fraction comprises ultracentrifugation, ultrafiltration, continuous flow electrophoresis, chromatography, precipitation or cross-flow ultrafiltration.

28. A kit comprising an agent which specifically binds fibrinogen and an agent which specifically binds Ciz1 b-variant.

29. A kit according to claim 28 wherein the fibrinogen is fibrinogen alpha chain.

30. A kit according to claim 28 wherein the agent which specifically binds fibrinogen and/or the agent which specifically binds Ciz1 b-variant is an antibody or a fragment thereof, a non-protein scaffold or an aptamer.