Patent application title: METHOD FOR PRODUCING DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID-TYPE CARBOXYMETHYLCELLULOSE, DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID-TYPE CARBOXYMETHYLCELLULOSE, AND ORALLY DISINTEGRATING TABLET INCLUDING DISINTEGRATING PARTICULATE COMPOSITION COMPRISING ACID-TYPE CARBOXYMETHYLCELLULOSE
Inventors:
Takahiro Hiramura (Tokyo, JP)
Kiyoshi Ikura (Hyogo, JP)
Sae Itaya (Hyogo, JP)
Tomohito Okabayashi (Hyogo, JP)
Naohiro Hashikawa (Hyogo, JP)
Tetsuro Morita (Hyogo, JP)
Kimiko Ikeda (Hyogo, JP)
Haruka Wakayma (Hyogo, JP)
IPC8 Class: AA61K920FI
USPC Class:
Class name:
Publication date: 2015-06-25
Patent application number: 20150174075
Abstract:
An object of the present application is to provide an
orally-disintegrating tablet having excellent tablet hardness and
disintegrability and a disintegrative particulate composition by which
the orally-disintegrating tablet can be obtained with a relatively low
tablet compression force and which can provide excellent moldability, as
well as a method of producing the same, etc. The present application
relates to a method of producing a disintegrative particulate composition
including three components consisting of a first disintegrator component
of an acid-type carboxymethylcellulose, a second disintegrator component
and an excipient, the method including a first wet granulation step using
any two of the three components, and a second wet granulation step using
granules obtained in the first wet granulation step and the remaining one
component of the three components not used in the first wet granulation
step; a production method further including a crystalline cellulose as a
fourth component; a production method including a third step of mixing a
crystalline cellulose into granules obtained in the second wet
granulation step; disintegrative particulate compositions obtained by
these methods, etc.Claims:
Description:
User Contributions:
Comment about this patent or add new information about this topic: