METHODS FOR TREATING CHANNELOPATHIES

Abstract

The present invention is directed to the use of a class of peptide compounds for treating diseases associated with hyperexcitability. The present invention is also directed to the use of a class of peptide compounds for treating diseases associated with dysfunction of an ion channel.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application is a divisional of pending U.S. application Ser. No. 12/306,953 filed on 30 Dec. 2008, which is a national stage entry of International Patent Application No. PCT/EP2007/005806 filed on 29 Jun. 2007, which claims priority to the following applications: EP 06013655.3 filed on 30 Jun. 2006; EP 06021469.9 filed on 12 Oct. 2006; EP 06021470.7 filed on 12 Oct. 2006; and EP 06024241.9 filed on 22 Nov. 2006. Each of the above-referenced applications is incorporated herein by reference in its entirety.

REFERENCE TO A SEQUENCE LISTING

[0002] This application contains references to amino acid sequences and/or nucleic acid sequences which have been submitted concurrently herewith as the sequence listing text file "61148780_--1.txt," file size 390 KiloBytes (KB), created on 3 Sep. 2009. The aforementioned sequence listing is hereby incorporated by reference in its entirety pursuant to 37 C.F.R. §1.52(e)(5).

BACKGROUND

[0003] The present invention is directed to the use of a class of peptide compounds for treating diseases associated with hyperexcitability, such as diseases associated with a hyperexcitable tissue. The present invention is also directed to the use of a class of peptide compounds for treating diseases associated with dysfunction of an ion channel.

[0004] Certain peptides are known to exhibit central nervous system (CNS) activity and are useful in the treatment of epilepsy and other CNS disorders. These peptides are described in the U.S. Pat. No. 5,378,729 and in U.S. Pat. No. 5,773,475, which are hereby incorporated by reference.

[0005] WO 02/074297 relates to the use of peptidic compounds for the preparation of pharmaceutical compositions useful for the treatment of allodynia related to peripheral neuropathic pain. WO 02/074784 relates to the use of peptidic compounds showing antinociceptive properties for treating different types and symptoms of acute and chronic pain, especially non neuropathic inflammatory pain, e.g. rheumatoid arthritic pain or/and secondary inflammatory osteo-arthritic pain.

[0006] According to their mode of regulation, ion channels can be divided into voltage-gated ion channels and ligand-gated ion channels. Ligand-gated ion channels are also referred to as receptors. Examples for voltage-gated ion channels are voltage-gated sodium channels, voltage-gated calcium channels, voltage-gated potassium channels, and voltage-gated chloride channels. Examples for ligand-gated ion channels are nicotinic acetylcholine receptors, ryanodine receptors (calcium release channels), cyclic nucleotide-gated receptors, ATP-receptors, GABA-A receptors, glutamate-NMDA receptors, glycine-receptors, 5-HT3-receptors, and pH sensitive channels such as acid-sensing ion channel (ASIC), and TRP receptors.

[0007] Hyperexcitability is defined herein as an abnormal increase in responsiveness of a central or peripheral nervous system neuron to synaptic input. In addition, hyperexcitability is also referred to as an abnormal increase in responsiveness of any excitable membrane, such as a muscle cell membrane, to a physiological signal or to excitotoxicity caused by a pathophysiological signal.

[0008] Examples for hyperexcitable tissues are all innervated tissues such as central or peripheral nervous tissue, muscle tissue, and other organ tissue.

[0009] Examples for diseases associated with hyperexcitability are channelopathies, anxiety- and stress-diseases.

[0010] Hyperexcitability can be induced by dysfunction of ion channels. According to their mode of regulation, ion channels can be divided into voltage-gated ion channels and ligand-gated ion channels. Ligand-gated ion channels are also referred to as receptors. Examples for voltage-gated ion channels are voltage-gated sodium channels, voltage-gated calcium channels, voltage-gated potassium channels, and voltage-gated chloride channels. Examples for ligand-gated ion channels are nicotinic acetylcholine receptors, ryanodine receptors (calcium release channels), cyclic nucleotide-gated receptors, ATP-receptors, GABA-A receptors, glutamate-NMDA receptors, glycine-receptors, 5-HT3-receptors, and pH sensitive channels such as acid-sensing ion channel (ASIC), and TRP receptors.

[0011] Ion channel dysfunction may have genetic or other causes, such as tissue damage.

[0012] Diseases caused by one or more mutations of genes coding for ion channel subunits or proteins that regulate them are referred to as channelopathies. There are a large number of distinct dysfunctions known to be caused by ion channel mutations. They comprise a heterogenous group of usually hereditary disorders which in most cases are clinically characterized by episodes of disturbed excitability of nerve or muscle cells. The genes for the construction of ion channels are highly conserved amongst mammals and one condition, hyperkalemic periodic paralysis, was first identified in the descendants of Impressive, a pedigree race horse. Well known examples of identified channelopathies are diseases of the skeletal muscle (such as hyper-, hypo- and normokalemic (high, low and normal potassium blood concentrations) periodic paralysis, paroxysmal dystonia, myotonia congenita and paramyotonia congenita), central nervous disorders of excitability (such as episodic ataxias and several forms of inherited epilepsies), and cardiac arrhythmias (such as long QT syndromes).

[0013] Ion channels dysfunctions can also be caused by variations in ion channel genes that are not sufficiently severe to be classified as mutations, but instead are referred to as polymorphisms. Such polymorphisms may contribute to unique drug responses in carriers of these gene variants (Kass, R S, J Clin Invest (2005), 115:1986-1989).

[0014] Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in excitable cells. The excitability of tissues depends mainly on the number of voltage-gated sodium channels that are available for activation. The fraction of sodium channels available for activation is regulated by fast inactivation, which occurs on a millisecond time scale, and slow inactivation occurring within seconds or minutes.

[0015] Mutations in genes coding for sodium channels are known to cause a number of characteristic diseases. Most inherited sodium channel mutations that are associated with human disease alter the inactivation process and hence alter the essential control of electrical-impulse duration that is effected by transition into the inactivated state (Jurkat-Rott, K, J Clin Invest (2005), 115:2000-2009). Most well characterised mutations are at the SCN4A sodium channel gene which codes for the alpha-subunit of the skeletal muscle sodium channel. Following diseases are listed in the OMIM database of NCBI for the SCN4A gene:

[0016] Cramps, familial, potassium-aggravated MIM: 603967

[0017] Hyperkalemic periodic paralysis MIM: 170500

[0018] Hypokalemic periodic paralysis MIM: 170400

[0019] Myotonia congenita, atypical, acetazolamide-responsive MIM: 608390

[0020] Paramyotonia congenita MIM: 168300.

[0021] Dystonia (literally, "abnormal muscle tone") is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. Dystonia may affect muscles throughout the body (generalised), in certain parts of the body (segmental), or may be confined to particular muscles or muscle groups (focal). Primary dystonia is caused by a pathology of the central nervous system, likely originating in those parts of the brain concerned with motor function, such as the basal ganglia. An example for dystonia associated with dysfunction of the voltage-gated sodium channel is paroxysmal dystonia.

[0022] Muscle weakness (or "lack of strength") is the inability to exert force with ones muscles to the degree that would be expected given the individual's general physical fitness. A test of strength is often used during a diagnosis of a muscular disorder before the etiology can be identified.

[0023] The term subsumes two other more specific terms, true weakness and perceived weakness. True weakness (or "objective weakness") describes a condition where the instantaneous force exerted by the muscles is less than would be expected. For instance, if a patient suffers from amyotrophic lateral sclerosis (ALS), motor neurons are damaged and can no longer stimulate the muscles to exert normal force. Perceived weakness (or "subjective weakness") describes a condition where it seems to the patient that more effort than normal is required to exert a given amount of force. For instance, a person with chronic fatigue syndrome may struggle to climb a set of stairs when feeling especially fatigued, but if their muscle strength is objectively measured (eg, the maximum weight they can press with their legs) it is essentially normal. In some conditions such as myasthenia gravis muscle strength is normal when resting, but true weakness occurs after the muscle has been subjected to exercise.

[0024] Myotonia is a neuromuscular disorder characterized by the slow relaxation of the muscles after voluntary contraction or electrical stimulation. Generally, repeated effort is needed to relax the muscles, and the condition improves after the muscles have warmed-up. However, prolonged, rigorous exercise may also trigger the condition. Individuals with the disorder may have trouble releasing their grip on objects or may have difficulty rising from a sitting position and a stiff, awkward gait. During pregnancy, symptoms of myotonia are more frequently experienced in women.

[0025] Myotonia can affect all muscle groups. It may be acquired or inherited, and is caused by an abnormality in the muscle membrane. Myotonia is a symptom commonly seen in patients with myotonic muscular dystrophy and channelopathies. Myotonia arising from channelopathies can be exacerbated by exposure to cold, by eating foods that are potassium-rich (such as bananas), and with exertion.

[0026] Myasthenias are a group of disorders which exhibit several striking features the essential one being a fluctuating weakness and fatigability of muscle. There is usually some degree of weakness at all times but it is made worse by activity. The weakness and fatigability reflect physiologic abnormalities of the neuromuscular junction that are demonstrated by clinical signs and special electrophysiologic testing.

[0027] Paralysis is the complete loss of muscle function for one or more muscle groups. Major causes are stroke, trauma, poliomyelitis, amyotrophic lateral sclerosis (ALS), botulism, spina bifida, and Guillain-Barre syndrome. Paralysis is most often caused by damage to the nervous system or brain, especially the spinal cord. Paralysis often includes loss of feeling in the affected area.

[0028] Paramyotonia Congenita (PC) is a rare congenital autosomal dominant neuromuscular disorder characterized by "paradoxical" myotonia. This type of myotonia has been termed paradoxical because it becomes worse with exercise whereas classical myotonia, as seen in myotonia congenita, is alleviated by exercise. PC is also distinguished as it can be induced by cold temperatures. Although more typical of the periodic paralytic disorders, patients with PC may also have potassium provoked paralysis. PC typically presents within the first decade of life and has 100% penetrance. Patients with this disorder commonly present with myotonia in the face or upper extremities. The lower extremities are generally less affected. While some other related disorders result in muscle atrophy, this is not normally the case with PC. This disease can also present as hyperkalemic periodic paralysis and there is debate as to whether the two disorders are actually distinct. Patients typically complain of muscle stiffness that can continue to focal weakness. This muscle stiffness cannot be walked-off, in contrast to myotonia congenita. These symptoms are increased (and sometimes induced) in cold environments. For example, some patients have reported that eating ice cream leads to a stiffening of the throat. For other patients, exercise consistently induces symptoms of myotonia and/or weakness. Typical presentations of this are during squating or repetitive first clenching. Some patients also indicate that specific foods are able to induce symptoms of paramyotonia congenita. Isolated cases have reported that carrots and watermelon are able to induce these symptoms. The canonical definition of this disorder precludes permenant weakness in the definition of this disorder. In practice, however, this has not been strictly adhered to in the literature. Diagnosis of paramyotonia congenita is made upon evaluation of patient symptoms and case history. Myotonia must increase with exercise/movement and usually must worsen in cold temperatures. Patients that present with permanent weakness are normally not characterized as having PC. Electromyography may be used to distinguish between paramyotonia congenita and myotonia congenita. Clinicians may also attempt to provoke episodes or myotonia and weakness/paralysis in patients in order to determine whether the patient has PC, hyperkalemic periodic paralysis, or one of the potassium-aggravated myotonias. Genomic sequencing of the SCN4A gene is the definitive diagnostic determinant.

[0029] Some patients do not require treatment to manage the symptoms of paramyotonia congenita. Others, however, require treatment for their muscle stiffness and often find mexiletine to be helpful. Others have found acetazolamide to be helpful as well. Avoidance of myotonia triggering events is also an effective method of mytonia prevention.

[0030] Paramyotonia congenita (as well as hyperkalemic periodic paralysis and the potassium-aggravated myotonias) is caused by mutations in SCN4A. The phenotype of patients with these mutations is indicated in Table 1 below. These mutations affect fast inactivation of the encoded sodium channel. There are also indications that some mutations lead to altered activation and deactivation. The result of these alterations in channel kinetics is that there is prolonged inward (depolarizing) current following muscle excitation. There is also the introduction of a "window current" due to changes in the voltage sensitivity of the channel's kinetics.

TABLE-US-00001 TABLE 1 Mutations of SCN4A (adapted from Vicart et al., 2005). Mutation region nomenclature is: domain number (e.g., D1) followed by segment number (e.g., S4). Thus, D2S3 indicates that the mutation is in the 3^rd membrane spanning loop of the 2^nd domain. Some mutations occur between segments and are denoted similarly (e.g., D4S4-S5 occurs between the 4^th and 5^th segments of the 4^th domain). Other mutations are located between domains and are denoted DX-Y where X and Y are domain numbers. C-term refers to the carboxy-terminus. Mutation Region I693T D2S4-S5 T704M* D2S5 S804F** D2S6 A1152D D3S4-S5 A1156T* D3S4-S5 V1293I D3S4 G1306V** D3-4 T1313A D3-4 T1313M D3-4 M1360V* D4S1 M1370V* D4S1 L1433R D4S3 R1448C D4S4 R1448H D4S4 R1448P D4S4 R1448S D4S4 R1456E D4S4 V1458F D4S4 F1473S D4S4-S5 M1592V* D4S6 G1702K C-term F1795I C-term *Symptoms of both PC and hyperKPP (Periodica paralytica paramyotonica) **Also diagnosed as a Potassium-aggravated myotonia

[0031] Diseases associated with hyperexcitability or/and diseases associated with dysfunction of an ion channel might be caused by genetic dysfunction of voltage- or ligand-gated ion channels, such as voltage-gated calcium channels, voltage-gated potassium channels, voltage-gated chloride channels, nicotinic acetylcholine receptors, ryanodine receptors (calcium release channels), cyclic nucleotide-gated receptors, ATP-receptors, GABA-A receptors, glutamate-NMDA receptors, glycine-receptors, 5-HT3-receptors, and pH sensitive channels such as acid-sensing ion channel (ASIC), and TRP receptors. Diseases associated with dysfunction of these ion channels include, among others, ataxias, myotonias, myasthenias, long QT syndromes, epilepsy syndromes, and hyperthermia.

[0032] Examples for further diseases associated with hyperexcitability that might be caused by other reasons than mutations and polymorphisms in genes coding for ion channel subunits or proteins that regulate them are anxiety and stress. Stress and other anxiogenic stimuli can cause hyperexcitability of amygdala neurones (Rainnie et al. J Neuroscience 2004 24(14):3471-3479). Since the amygdala is a key brain center for emotion acute severe or chronic mild stress can result in persistent changes in emotion as for instance found in patients suffering from post-traumatic stress disorder.

[0033] Lacosamide does not exert its effects on neuronal excitability by affecting fast inactivation gating of voltage-gated Na⁺ channels (Errington et al., Neuropharmacology, 2006, 50:1016-1029).

SUMMARY

[0034] The present invention demonstrates that the compounds of Formulae (I), (II), or/and (III) as defined herein, in particular lacosamide, are capable of selectively enhancing slow inactivation of voltage-gated sodium channels while leaving activation and fast inactivation behaviour normal. This constitutes a novel mechanism of action of the compounds of Formulae (I), (II), or/and (III), which thus can positively influence diseases associated with hyperexcitability. Due to this novel mechanism of action, the compounds of Formulae (I), (II), or/and (III) can efficiently normalize excessive sodium channel function such as a reduced slow inactivation which is e.g. seen in mutated channels. Further, this novel mechanism of action can compensate excessive function of other ion channels such as voltage-gated calcium channels, voltage-gated potassium channels, voltage-gated chloride channels, nicotinic acetylcholine receptors, ryanodine receptors (calcium release channels), cyclic nucleotide-gated receptors, ATP-receptors, GABA-A receptors, glutamate-NMDA receptors, glycine-receptors, 5-HT3-receptors, and pH sensitive channels such as acid-sensing ion channel (ASIC), and TRP receptors.

[0035] The mode of action of the compounds of Formulae (I), (II) or/and (III) differs from that of common drugs used for the treatment of voltage-gated sodium channel associated diseases. Common drugs used for the treatment of voltage-gated sodium channel associated diseases often affect fast inactivation of voltage-gated sodium channels and therefore affect signal propagation in excitable tissues. In contrast, the compounds of Formulae (I), (II) or/and (III) cause a shift of the curve of slow inactivation to more negative potentials, which reduces excitability, but does not affect signal propagation.

[0036] Lehmann-Horn et al. (Current Neurology and Neuroscience Reports (2002) 2:61-69) report that the common mechanism for inexcitability in all known episodic-weakness phenotypes, such as episodic familial periodic paralysis, is a long-lasting depolarization that inactivates sodium ion channels. By the compounds of the present invention, inactivation may be restored at least partially in such patients.

[0037] The use of compounds of Formulae (I), (II), or/and (III) for the treatment of a disease associated with hyperexcitability or/and for the treatment of a disease associated with dysfunction of an ion channel has not been reported. Thus, the present invention concerns the use of the compounds of Formula (I), (II), or/and (III) for the preparation of a pharmaceutical composition for the prevention, alleviation or/and treatment of a disease associated with hyperexcitability. The present invention also concerns the use of the compounds of Formula (I), (II), or/and (III) for the preparation of a pharmaceutical composition for the prevention, alleviation or/and treatment of a disease associated with dysfunction of an ion channel.

BRIEF DESCRIPTION OF THE DRAWINGS

[0038] FIG. 1A is a chart showing a fraction of channels available after a repolarizing pulse of -100 mV and -60 mV, respectively.

[0039] FIG. 1B is a chart showing voltage dependency of slow inactivation in the presence or absence of lacosamide.

[0040] FIG. 2 is a chart showing an effect of chlordiazepoxide, pregabalin and lacosamide on stress-induced hyperthermia in mice.

[0041] FIG. 3 is a chart showing effect of lacosamide on neuronal damage in CA1-CA3 after glutamate excitotoxicity (Glut), as assessed by densitometric quantification of propidium-iodide uptake.

[0042] FIG. 4 is a chart showing effect of lacosamide on neuronal damage in CA1-CA3 after glutamate excitotoxicity (Glut), as assessed by colorimetric quantification of LDH release 24 hours after Glut onset.

[0043] FIG. 5A is a chart showing that lacosamide shifts the slow inactivation voltage curve to more hyperpolarized membrane potentials in Xenopus oocytes expressing the alpha subunit of the rat type II sodium channel.

[0044] FIG. 5B is a chart showing that in rat dorsal root ganglia, lacosamide at 100 μM increases the maximal fraction of slowly inactivated TTX-resistant sodium current.

[0045] FIG. 5C is a chart showing that lacosamide does not delay recovery from slow inactivation.

DETAILED DESCRIPTION

[0046] In the context of the present invention, hyperexcitability includes:

[0047] Hyperactivity associated with ion channels:

[0048] Lacosamide interacts with voltage-gated sodium channels in a novel manner (Examples 1 and 4): in contrast to all other drugs it enhances slow rather than fast inactivation of these channels. This is an efficient way to reduce pathological sodium channel hyperactivity e.g. induced by sodium channelopathies. By enhancing slow inactivation of sodium channels, hyperactivity of channellopathies associated with channels different from sodium channel may also be reduced.

[0049] Hyperactivity resulting in neurodegeneration:

[0050] Hyperexcitability e.g. as mediated by defective sodium channel activity can results in neurodeneration--a phenomenone called exitotoxicity. Lacosamide effectively blocks exitotoxicity (Example 3) thus preventing the toxic effects of hyperexcitability. Thus these effects can be discriminated from direct effects on hyperexcitability since in this case the consequences are affected and not the hyperexcitability by itself. Such effects are the underlying causes for many CNS diseases with ongoing neurodegeneration e.g. Parkinson's Disease, Alzheimers Disease, bipolar disorder and schizophrenia.

[0051] Behavioural hyperactivity (i.e. hyperreactivity)

[0052] On a behavioural level hyperexcitability can present itself as an exaggareted response to stress such as observed in disease like anxiety, post-traumatic stress disorder, or obsessive compulsive disorder. Behavioural hyperexcitability does not necessarily depend on cellular hyperexcitability as for instance observed in disorders like epilepsy and neuropathic pain. Lacosamide attenuates stress-induced anxiety (Example 2) demonstrating its ability to reduce hyperexcitability also on a behavioural level.

[0053] In one embodiment, the disease associated with hyperexcitability is a disease associated with a hyperexcitable tissue.

[0054] In another embodiment, the disease associated with hyperexcitability is a disease associated with hyperexcitability on the behavioural level (i.e. a disease associated with hyperreactivity).

[0055] In yet another embodiment, the disease associated with hyperexcitability is a disease associated with neurodegeneration, such as e.g. Parkinson's Disease, Alzheimers Disease, bipolar disorder and schizophrenia.

[0056] The disease associated with hyperexcitability may be a disease associated with dysfunction of an ion channel, such as a voltage-gated ion channel or a ligand-gated ion channel.

[0057] In one embodiment of the present invention, the disease associated with dysfunction of an ion channel is associated with dysfunction of a voltage-gated ion channel, selected from a voltage-gated sodium channel, a voltage-gated calcium channel, a voltage-gated potassium channel, and a voltage-gated chloride channel or with dysfunction of a ligand-gated ion channel, selected from a nicotinic acetylcholine receptor, a ryanodine receptor, a cyclic nucleotide-gated receptor, an ATP-receptor, a GABA-A receptor, a glutamate-NMDA receptor, a glycine-receptor, a 5-HT3-receptor, and a pH sensitive channel.

[0058] The disease associated with dysfunction of an ion channel may be associated with dysfunction of a voltage-gated sodium channel. The disease associated with dysfunction of a voltage-gated sodium channel may be a disease associated with altered inactivation of voltage-gated sodium channels in comparison to a healthy subject, in particular altered slow inactivation. The disease associated with dysfunction of a voltage-gated sodium channel may also be a disease associated with altered inactivation of voltage-gated sodium channels in comparison to a healthy subject in which fast inactivation of sodium channels is altered.

[0059] In the disease associated with hyperexcitability or/and the disease associated with ion channel dysfunction, the curve of slow inactivation of a sodium channel may be affected, in particular the curve of slow inactivation is shifted to depolarized potentials compared with the slow inactivation curve of a healthy subject. Such functional alterations may be reversed completely or at least partially by the compounds of the present invention.

[0060] The voltage-gated sodium channel may be any known type of voltage-gated sodium channels, in particular any type expressed in excitable tissues, such as muscle and nerve. Examples of genes encoding voltage-gated sodium channels or/and subunits thereof include SCN1A, (Na_v 1.1), SCN2A (Na_v 1.2), SCN4A (Na_v 1.4), SCN5A (Na_v 1.5), SCN8A (Na_v 1.6), SCN9A (Na_v 1.7), Na_v 1.8 (SNS or PN3), and Na_v 1.9 (NaN, SNS-2 or PN-5). The voltage-gated sodium channel may comprise a type IV alpha subunit SCN4A. The voltage-gated sodium channel may also comprise Na_v1.2.

[0061] The disease associated with dysfunction of an ion channel may be associated with an ion channel different from a voltage-gated sodium channel, such as a voltage-gated calcium channel, a voltage-gated potassium channel, a voltage-gated chloride channel, a nicotinic acetylcholine receptor, a ryanodine receptor, a cyclic nucleotide-gated receptor, an ATP-receptor, a GABA-A receptor, a glutamate-NMDA receptor, a glycine-receptor, a 5-HT3-receptor, or a pH sensitive channel.

[0062] Dysfunction of an ion channel different from a voltage-gated sodium channel might cause alteration of electrolyte composition in body fluids, in particular in the intracellular fluid or/and in the extracellular fluid, such as in the plasma, which alteration may for instance influence the activation or/and inactivation state of a sodium channel by altering the resting membrane potential. Alteration of electrolyte composition includes alterations of the Na⁺, K⁺, or/and Cl^{concentration} or pH. Dysfunction of an ion channel different from a voltage-gated sodium channel might also cause alteration of pre- or/and postsynaptic control, and alteration of synaptic transmitter release or/and postsynaptic transmitter action. Dysfunction of an ion channel different from a voltage-gated sodium channel might lead to a disease associated with hyperexcitability that can be prevented, alleviated or/and treated by a modulator of the activity of a voltage-gated sodium channel. A disease associated with dysfunction of an ion channel different from a voltage-gated sodium channel might be prevented, alleviated or/and treated by a modulator of the activity of a voltage-gated sodium channel.

[0063] Examples of genes encoding a voltage-gated calcium channel or/and a subunit thereof include CACNA1A (SEQ ID NO: 1), CACNA1S, and CACNB4. Examples of genes encoding a voltage-gated potassium channel or/and a subunit thereof include KCNA1, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNE1, KCNE2, and hERG. Examples of genes encoding a chloride channel or/and a subunit thereof include CLCN1, CLCN5, and CLCNKB. Examples of genes encoding a ligand-gated ion channel or/and a subunit thereof include CHRNA4 (nicotinic acetylcholine receptor), RYR1 (ryanodine receptor).

[0064] In another embodiment of the present invention, the disease of the present invention is a channelopathy. The channelopathy may be associated with a dysfunction of a voltage-gated sodium channel, a voltage-gated calcium channel, a voltage-gated potassium channel, a voltage-gated chloride channel, a nicotinic acetylcholine receptor, a ryanodine receptor, a cyclic nucleotide-gated receptor, an ATP-receptor, a GABA-A receptor, a glutamate-NMDA receptor, a glycine-receptor, a 5-HT3-receptor, or/and a pH sensitive channel, as described herein, which dysfunction may be caused by a mutation. The channelopathy may be selected from familial potassium-aggravated cramps (e.g. MIM: 603967), myasthenic syndrome (e.g. MIM: 603967), hyperkalemic periodic paralysis (e.g. MIM: 170500), hypokalemic periodic paralysis (e.g. MIM: 170400), atypical, acetazolamide-responsive myotonia congenita (e.g. MIM: 608390), and paramyotonia congenita (e.g. MIM: 168300). The channelopathy may also be associated with at least one of the following mutations of the SCN4A polypeptide: I693T, T704M, S804F, A1152D, A1156T, V1293I, G1306V, T1313A, T1313M, M1360V, M1370V, L1433R, R1448C, R1448H, R1448P, R1448S, R1456E, V1458F, F1473S, M1592V, G1702K, and F1795I.

[0065] In yet another embodiment, the disease of the present invention, in particular the disease associated with dysfunction of an ion channel, is a muscle disorder.

[0066] The disease of the present invention may be a skeletal muscle disorder or/and a movement disorder, in particular a movement disorder.

[0067] The skeletal muscle or/and movement disorder may be selected from myotonias and paralyses, in particular selected from inherited myotonia and periodic paralyses, such as paramyotonia congenita, potassium aggravated myotonia, myotonia fluctuans, myotonia permanens, acetazolamide responsive myotonia, hyperkalemic periodic paralysis, normokalemic paralysis, paroxysmal dystonia, Morvan syndrome and Isaak syndrome.

[0068] Paralysis may be associated with loss of feeling in the affected area. Further, paralysis may be associated with stroke, trauma, poliomyelitis, amyotrophic lateral sclerosis (ALS), botulism, spina bifida, Guillain-Barre syndrome, or/and damage of the nervous system or/and brain, especially the spinal cord.

[0069] The skeletal muscle or/and movement disorder may also be selected from ataxias, in particular selected from episodic ataxia 2, spinocerebellar ataxia 6, and episodic ataxia.

[0070] The skeletal muscle or/and movement disorder may also be selected from myotonias, in particular selected from Thomsen myotonia, Becker myotonia, myotonia congenita, generalized myotonia, myotonia levior.

[0071] The myotonia may be associated with slow relaxation of a muscle after voluntary contraction or electrical stimulation. The myotonia may be selected from acquired and inherited myotonia. The myotonia may be caused by an abnormality in the muscle membrane. The myotonia may be associated with myotonic muscular dystrophy or/and a channelopathy (in particular a channelopathy caused by mutations in the chloride, sodium or potassium ion channels in the muscle membrane).

[0072] The myotonia may be exacerbated by exposure to cold, by a potassium-rich diet (such as eating bananas), or/and with exertion, e.g. prolonged, rigorous exercise.

[0073] The skeletal muscle or/and movement disorder may be a myasthenia selected from myokymias and hypokalemic periodic paralysis 1.

[0074] The muscle disorder may be a cardiac arrhythmia selected from long QT syndrome 3, Long QT syndrome 5, Jervell- and Lange-Nielsen syndrome, inducible long QT syndrome, long QT syndrome 1, and long QT syndrome 2.

[0075] The disease of the present invention may be an epilepsy syndrome selected from generalized epilepsy with febrile seizures plus (GEFS+), severe myoclonic epilepsy in infancy (SMEI), benign familial neonatal infantile seizures (BNIFS), intractable childhood epilepsy with generalized tonic-clonic seizures (ICEGTC), infantile spasms (West syndrome), generalized epilepsy associated with CACNB4 dysfunction, benign familial neonatal convulsions 1, benign familial neonatal convulsions 2, and nocturnal frontal lobe epilepsy.

[0076] The disease of the present invention may be a pain syndrome selected from erythermalgia and familial rectal pain (also called "paroxysmal extreme pain disorder").

[0077] The disease of the present invention may be selected from dominant deafness, malignant hyperthermia 5, malignant hyperthermia 1, polycystic kidney disease 1, Dent's disease, Bartter syndrome, central core disorder, and cortical hyperexcitability associated with CACNA1A (SEQ ID NO:1).

[0078] In yet another embodiment, the disease associated with hyperexcitability may be a sodium channelopathy, such as a channelopathy selected from the diseases listed in Table 2a.

[0079] In a further embodiment, the disease associated with hyperexcitability is a potassium channelopathy, such as a channelopathy selected from the diseases associated with a potassium channel listed in Table 2b.

[0080] In a further embodiment, the disease associated with hyperexcitability is a calcium channelopathy, such as a channelopathy selected from the diseases associated with a calcium channel listed in Table 2b.

[0081] In yet another embodiment, the disease associated with hyperexcitability is a chloride channelopathy, such as a channelopathy selected from the diseases associated with a chloride channel listed in Table 2b.

[0082] In a further embodiment, the disease associated with hyperexcitability is selected from the diseases listed in Table 2c.

[0083] In another embodiment, the disease associated with dysfunction of an ion channel is a sodium channelopathy, such as a channelopathy selected from the diseases listed in Table 2a.

[0084] In yet another embodiment, the disease associated with dysfunction of an ion channel is a potassium channelopathy, such as a channelopathy selected from the diseases associated with a potassium channel listed in Table 2b.

[0085] In a further embodiment, the disease associated with dysfunction of an ion channel is a calcium channelopathy, such as a channelopathy selected from the diseases associated with a calcium channel listed in Table 2b.

[0086] In yet another embodiment, the disease associated with dysfunction of an ion channel is a chloride channelopathy, such as a channelopathy selected from the diseases associated with a chloride channel listed in Table 2b.

[0087] Table 2. Target diseases for selective enhancers of slow inactivation of voltage-gated Na⁺ channels in excitable tissues

TABLE-US-00002 TABLE 2a Dysfunction of voltage-gated sodium channels (sodium channelopathies) AFFECTED TISSUE skeletal muscle cardiac muscle CNS PNS inherited myotonia and cardiac arrhythmia epilepsy pain syndromes periodic paralyses SCN5A (Na_v 1.5) syndromes SNC9A (Na_v 1.7) SCN4A (Na_v 1.4) long QT syndrome 3 SCN1A, (Na_v 1.1), erythermalgia (cf. Table 54-1 in "Principles (Lehmann-Horn and SCN2A (Na_v 1.2) (=erythromelagia) of Neurology" & Lehmann- Jurkat-Rott generalized (Yang et al., 2004) Horn and Jurkat-Rott www.channelopathies.org) epilepsy with febrile familial rectal pain www.channelopathies.org) seizures plus (Meisler and Kearney, Paramyotonia congenita (GEFS+) 2005) Potassium aggravated severe myoclonic myotonia epilepsy in infancy Myotonia fluctuans (SMEI) Myotonia permanens benign familial Acetazolamide responsive neonatal infantile myotonia seizures (BNIFS) Hyperkalemic periodic intractable paralysis childhood epilepsy Normokalemic paralysis with generalized movement disorders: tonic-clonic seizures SCN8A (Na_v 1.6) (ICEGTC) paroxysmal dystonia infantile spasms (Siep et al., 2002) (West syndrome) Morvan syndrome (Meisler and Isaak syndrome Kearney, 2005)

TABLE-US-00003 TABLE 2b Dysfunction of other voltage-gated ion channels (channelopathies) AFFECTED TISSUE cardiac skeletal muscle muscle CNS Others Ataxias Long QT cortical hyperexcitability Auditory disorders: Episodic ataxia 2 syndrome 5 epilepsy syndromes Dominant deafness (CACNA1A) (KCNE1), Generalized epilepsy (KCNQ4) spinocerebellar ataxia 6 Jervell- and (CACNB4) Hyperthermia: (CACNA1A) Lange-Nielsen Benign familial neonatal Malignant KCNA1 (potassium Syndrome convulsions 1 (KCNQ2) hyperthermia 5 channel) episodic ataxia (KCNE1, KCNQ1), Benign familial neonatal (CACNA1S), Myotonias inducible long QT convulsions 2 (KCNQ3) malignant CLCN1 (chloride channel) syndrome nocturnal frontal lobe hyperthermia 1 e.g. Thomsen myotonia, (KCNE2) epilepsy (CHRNA4) (RYR1) Becker myotonia, long QT syndrome (Lehmann-Horn & Jurkat- Central core disease myotonia congenital, 1 (KCNQ1) Rott, 2000) (RYR1) generalized myotonia, long QT syndrome Renal disorders: myotonia levior 2 (hERG) Polycystic kidney Myasthenias disease (PKD1), KCNQ2 (potassium Dent's disease channel) myokymia (CLCN5), Bartter Hypokalemic periodic syndrome paralysis 1 (CACNA1S) (CLCNKB),

TABLE-US-00004 TABLE 2C Other diseases due to hyperexcitable tissue (Hyperexcitability Disorders) AFFECTED TISSUE CNS PNS Post traumatic stress disorder Peripheral nerve (Centonze et al. 2005) hyperexcitability Alzheimer's disease, Parkinson's disease, syndromes Bipolar disorder and Schizophrenia (Farber et al. 2002)

REFERENCES

[0088] Farber, N B et al., Molecular Psychiatry (2002), 7:726-733

[0089] Lehmann-Horn, Jurkat-Rott www.channelopathies.org

[0090] Meisler M H, Kearney J A. J Clin Invest. 2005 August; 115(8):2010-7. PMID: 16075041

[0091] Siep E, et al. Neurobiol Dis. 2002 March; 9(2):258-68.

[0092] Victor M, Ropper A H Adams and Victor's Principles of Neurology. 7^th edition, McGraw-Hill New York 2001.

[0093] Yang Y et al. J Med Genet. 2004 March; 41(3):171-4.

[0094] Based on the finding that the compounds of the present invention are capable of increasing slow inactivation of voltage-gated sodium channels and thereby act against hyperexcitability, it is concluded that the pharmaceutical composition of the present invention is suitable for the treatment of diseases associated with hyperexcitability, such as anxiety or/and stress.

[0095] Thus, in another embodiment of the present invention, the disease associated with hyperexcitability is a disease selected from anxiety, stress, posttraumatic stress disorder, obsessive compulsive disorder and peripheral nerve hyperexcitability syndromes. The disease may be stress-induced anxiety as for instance seen in post-traumatic stress disorder.

[0096] Hyperexcitability may cause neurodegeneration. Example 3 of the present invention demonstrates a neuroprotective effect of the compounds of the present invention. In one embodiment, the prevention, alleviation or/and treatment of a disease associated with hyperexcitability is effected by neuroprotection, in particular by short-term neuroprotection. In this embodiment of the present invention, the disease associated with hyperexcitability is a condition associated with neuronal damage or/and neurodegeneration. In particular, the disease associated with hyperexcitability is a condition associated with neuronal damage or/and neurodegeneration caused by a neurodegenerative disease or/and a psychotic disease. The neurodegenerative disease or/and the psychotic disease may be selected from Alzheimer's disease, Parkinson's disease, bipolar disorder, and schizophrenia.

[0097] In one embodiment of the present invention, the disease associated with hyperexcitability is not epilepsy, status epilepticus, pain, neuropathic pain, allodynia or hyperalgesia. In another embodiment, the disease associated with hyperexcitability is not an epilepsy related condition or a neuropathic pain related condition. In a further embodiment, the specific forms of epilepsy and pain as described herein are not subject of these disclaimers.

[0098] In another embodiment of the present invention, the disease associated with dysfunction of an ion channel is not epilepsy, status epilepticus, pain, neuropathic pain, allodynia or hyperalgesia. In another embodiment, the disease associated with dysfunction of an ion channel is not an epilepsy related condition or a neuropathic pain related condition. In a further embodiment, the specific forms of epilepsy and pain as described herein are not subject of these disclaimers.

[0099] In yet another embodiment, the disease associated with hyperexcitability is not amyotrophic lateral sclerosis or Guillain-Barre syndrome. In a further embodiment, paralysis associated with amyotrophic lateral sclerosis or/and Guillain-Barre syndrome as described herein is not subject of this disclaimer.

[0100] In a further embodiment, the disease associated with dysfunction of an ion channel is not amyotrophic lateral sclerosis or Guillain-Barre syndrome. In a further embodiment, paralysis associated with amyotrophic lateral sclerosis or/and Guillain-Barre syndrome as described herein is not subject of this disclaimer.

[0101] In a further embodiment, the disease associated with hyperexcitability is not Alzheimer's disease, Parkinson's disease, bipolar disorder, or schizophrenia. In a further embodiment, a condition associated with neuronal damage or/and neurodegeneration caused by a neurodegenerative disease or/and psychotic disease selected from Alzheimer's disease, Parkinson's disease, bipolar disorder, and schizophrenia is not subject of this disclaimer.

[0102] In yet another embodiment, the disease associated with hyperexcitability is not tinnitus or obsessive compulsive disorder.

[0103] The compounds of the present invention of Formulae (I), (II) or/and (III), in particular lacosamide, are well tolerated, which is an advantage over other commonly used therapeutics for treatment of diseases associated with hyperexcitability or/and of diseases associated with dysfunction of an ion channel.

[0104] The compounds of the present invention, in particular lacosamide, may be used in a first line treatment of a disease as defined herein. Therefore, the pharmaceutical composition of the present invention is suitable for a first line treatment of a disease as defined herein.

[0105] The compounds of the present invention may also be used in a second line treatment of a disease as defined herein. Therefore, the pharmaceutical composition of the present invention is also suitable for a second line treatment of a disease as defined herein.

[0106] Yet another aspect of the present invention is a pharmaceutical composition comprising at least one compound of Formulae (I), (II), or/and (III) as defined herein, preferably lacosamide, for the prevention, alleviation or/and treatment of a disease associated with hyperexcitability, as defined herein.

[0107] Yet another aspect of the present invention is a pharmaceutical composition comprising at least one compound of Formulae (I), (II), or/and (III) as defined herein, preferably lacosamide, for the prevention, alleviation or/and treatment of a disease associated with dysfunction of an ion channel, as defined herein.

[0108] The components of Formulae (I), (II), or/and (III) may also be administered together with a further active agent for the treatment of a disease associated with hyperexcitability, as defined herein.

[0109] The components of Formulae (I), (II), or/and (III) may also be administered together with a further active agent for the treatment of a disease associated with dysfunction of an ion channel, as defined herein.

[0110] A further aspect of the present invention refers to a pharmaceutical composition.

[0111] In one embodiment, the pharmaceutical composition comprises

[0112] (a) at least one compound of Formulae (I), (II), or/and (III) as defined herein, preferably lacosamide, and

[0113] (b) at least one further active agent for the prevention, alleviation, or/and treatment of a disease associated with hyperexcitability as defined herein.

[0114] In another embodiment, the pharmaceutical composition comprises

[0115] (a) at least one compound of Formulae (I), (II), or/and (III) as defined herein, preferably lacosamide, and

[0116] (b) at least one further active agent for the prevention, alleviation, or/and treatment of a disease associated with dysfunction of an ion channel as defined herein.

[0117] In the embodiments as indicated above, the compound of Formulae (I), (II), or/and (III) and the further active agent (b) may be formulated in one pharmaceutical preparation (single dosage form) for administration at the same time or may be formulated in two or more distinct preparations (separate dosage forms) for simultaneous or/and subsequent administration. The two distinct preparations in the separate dosage forms may be administered by the same route or by different routes.

[0118] Separate dosage forms can optionally be co-packaged, for example in a single container or in a plurality of containers within a single outer package, or co-presented in separate packaging ("common presentation"). As an example of co-packaging or common presentation, a kit is contemplated comprising, in separate containers, compound of Formulae (I), (II), or/and (III) and the further active agent (b). In another example, the compound of Formulae (I), (II), or/and (III) and the further active agent (b) are separately packaged and available for sale independently of one another, but are co-marketed or co-promoted for use according to the invention. The separate dose forms may also be presented to a subject separately and independently, for use according to the invention.

[0119] In one embodiment, the pharmaceutical composition comprises a single dosage form comprising at least one compound of Formulae (I), (II), or/and (III) and at least one further active agent (b).

[0120] In another embodiment, the pharmaceutical composition of the present invention comprises separate dosage forms comprising

[0121] (i) a first composition comprising at least one compound of Formulae (I), (II), or/and (III), and

[0122] (ii) a second composition comprising at least one further active agent for the prevention, alleviation, or/and treatment of disease associated with hyperexcitability, as defined herein.

[0123] In yet another embodiment, the pharmaceutical composition of the present invention comprises separate dosage forms comprising

[0124] (i) a first composition comprising at least one compound of Formulae (I), (II), or/and (III), and

[0125] (ii) a second composition comprising at least one further active agent for the prevention, alleviation, or/and treatment of disease associated with dysfunction of an ion channel, as defined herein.

[0126] In yet another embodiment of the present invention, the second composition (ii) comprising the at least one further active agent may be a commercially available composition.

[0127] The pharmaceutical composition of the present invention may be prepared for administration in mammals, such as in humans.

[0128] The pharmaceutical composition of the present invention comprising (a) at least one compound of Formulae (I), (II) or/and (III) and (b) at least one further active agent may be prepared for the prevention, alleviation or/and treatment of disease associated with hyperexcitability, as described herein.

[0129] The pharmaceutical composition of the present invention comprising (a) at least one compound of Formulae (I), (II) or/and (III) and (b) at least one further active agent may be prepared for the prevention, alleviation or/and treatment of disease associated with dysfunction of an ion channel, as described herein.

[0130] Yet another aspect of the present invention is a method for the prevention, alleviation or/and treatment of a disease.

[0131] In one embodiment, the method is a method for the prevention, alleviation or/and treatment of a disease associated with hyperexcitability, wherein the method comprises administering to a subject in need thereof at least one compound of Formulae (I), (II), or/and (III), in particular lacosamide.

[0132] In another embodiment, the method is a method for the prevention, alleviation or/and treatment of a disease associated with hyperexcitability, wherein the method comprises co-administering to a subject in need thereof at least one compound of Formulae (I), (II), or/and (III), in particular lacosamide, and a further active agent for the prevention, alleviation, or/and treatment of a disease associated with hyperexcitability in therapeutically effective amounts.

[0133] In another embodiment, the method is a method for the prevention, alleviation or/and treatment of a disease associated with dysfunction of an ion channel, wherein the method comprises administering to a subject in need thereof at least one compound of Formulae (I), (II), or/and (III), in particular lacosamide.

[0134] In yet another embodiment, the method of the present invention is a method for the prevention, alleviation or/and treatment of a disease associated with dysfunction of an ion channel, wherein the method comprises co-administering to a subject in need thereof at least one compound of Formulae (I), (II), or/and (III), in particular lacosamide, and a further active agent for the prevention, alleviation, or/and treatment of a disease associated with dysfunction of an ion channel in therapeutically effective amounts.

[0135] The at least one compound of formulae (I), (II), or/and (III), in particular lacosamide, may be co-administered with mexiletine, carbonic anhydrase inhibitors (such as acetazolamide or dichlorphenamide), benzodiazepines (such as diazepam, midazolam, alprazolam), SSRIs (selective serotonin reuptake inhibitors such as fluoxetine, fluvoxamine, sertraline, venlafaxine, mirtazapine), baclofen, quinine, phenyloin and other anticonvulsant drugs (such as lamotrigine, levetiracetam, topiramate, carbamazepine, oxcarbazepine, tiagabine, vigabatrine, zonisamide), tricyclic antidepressants (such as amitryptiline, imipramine, desipramine), nonsteroidal antiinflammatory drugs (NSAIDs such as acetylsalicylic acid, paracetamol, ibuprofen, naproxen), acetylcholinesterase inhibitors (AChE) inhibitors (such as tacrine, rivastigmine, galanthamine, donezepil), dopa decarboxylase inhibitors, dopamine agonists (such as ropinirole, pramipexole, lisuride, pergolide, piribedil), monoamine oxidase-B and COMT inhibitors (such as tolcapone, entacapone, apomorphine, rasagiline), atypical antipsychotic medications (such as clozapine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and amisulpride), or potassium tablets.

[0136] The term "co-administration" refers to a plurality of agents that, when administered to a subject together or separately, are co-active in bringing therapeutic benefit to the subject. Such co-administration is also referred to as "combination", "combination therapy," "co-therapy," "adjunctive therapy" or "add-on therapy." For example, one agent can enhance the therapeutic effect of another, or reduce an adverse side effect of another, or one or more agents can be effectively administered at a lower dose than when used alone, or can provide greater therapeutic benefit than when used alone, or can complementarily address different aspects, symptoms or etiological factors of a disease or condition.

[0137] Co-administration comprises administration of the combination of the agents in amounts sufficient to achieve or/and maintain therapeutically effective concentrations, e.g. plasma concentrations, in the subject in need thereof. Co-administration comprises simultaneous or/and subsequent administration. Simultaneous administration comprises administration of the agents as a single or as different compositions.

[0138] The administration interval of the compound of Formulae (I), (II), or/and (III) and the further active agent may depend on the dosage forms. The compound of Formulae (I), (II), or/and (III) may be administered first, or the further active agent (b) may be administered first.

[0139] The compound according to the invention has the general Formula (I)

##STR00001##

wherein

[0140] R is hydrogen, alkyl, alkenyl, alkynyl, aryl, aryl alkyl, heterocyclic, heterocyclic alkyl, alkyl heterocyclic, cycloalkyl or cycloalkyl alkyl, and R is unsubstituted or is substituted with at least one electron withdrawing group, or/and at least one electron donating group;

[0141] R₁ is hydrogen or alkyl, alkenyl, alkynyl, aryl alkyl, aryl, heterocyclic alkyl, alkyl heterocyclic, heterocyclic, cycloalkyl, cycloalkyl alkyl, each unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group;

and

[0142] R₂ and R₃ are independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, aryl alkyl, aryl, halo, heterocyclic, heterocyclic alkyl, alkyl heterocyclic, cycloalkyl, cycloalkyl alkyl, or Z--Y wherein R₂ and R₃ may be unsubstituted or substituted with at least one electron withdrawing group or/and at least one electron donating group;

[0143] Z is O, S, S(O)_a, NR₄, NR'₆, PR₄ or a chemical bond;

[0144] Y is hydrogen, alkyl, aryl, aryl alkyl, alkenyl, alkynyl, halo, heterocyclic, heterocyclic alkyl, alkyl heterocyclic and Y may be unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group, provided that when Y is halo, Z is a chemical bond, or

[0145] ZY taken together is NR₄NR₅R₇, NR₄OR₅, ONR₄R₇, OPR₄R₅, PR₄OR₅, SNR₄R₇, NR₄SR₇, SPR₄R₅, PR₄SR₇, NR₄PR₅R₆, PR₄NR₅R₇ or N+R₅R₆R₇,

##STR00002##

[0146] R'₆ is hydrogen, alkyl, alkenyl, or alkenyl which may be unsubstituted or substituted with at least one electron withdrawing group or/and at least one electron donating group;

[0147] R₄, R₅ and R₆ are independently hydrogen, alkyl, aryl, aryl alkyl, alkenyl, or alkynyl, wherein R₄, R₅ and R₆ may independently be unsubstituted or substituted with at least one electron withdrawing group or/and at least one electron donating group;

[0148] R₇ is R₆ or COOR₈ or COR₈, which R₇ may be unsubstituted or substituted with at least one electron withdrawing group or/and at least one electron donating group;

[0149] R₈ is hydrogen or alkyl, or aryl alkyl, and the aryl or alkyl group may be unsubstituted or substituted with at least one electron withdrawing group or/and at least one electron donating group; and

n is 1-4; and a is 1-3.

[0150] In a preferred embodiment, the compound of Formula (I) has the general Formula (II),

##STR00003##

wherein

[0151] Ar is aryl which is unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group, preferably halo, more preferably fluoro; R₁ is alkyl, preferably alkyl containing 1-3 carbon atoms, more preferably methyl; and R₃ is as defined herein.

[0152] In a more preferred embodiment, the compound of Formulae (I) or/and (II) has the general Formula (III),

##STR00004##

wherein

[0153] R₉ is one or more substituents independently selected from the group consisting of hydrogen, halo, alkyl, alkenyl, alkynyl, nitro, carboxy, formyl, carboxyamido, aryl, quaternary ammonium, haloalkyl, aryl alkanoyl, hydroxy, alkoxy, carbalkoxy, amino, alkylamino, dialkylamino, aryloxy, mercapto, alkylthio, alkylmercapto, and disulfide;

[0154] R₃ is selected from the group consisting of hydrogen, alkyl, arylalkyl, alkoxy, alkoxyalkyl, aryl, heterocyclic, heterocyclic alkyl, N-alkoxy-N-alkylamino, N-alkoxyamino, and N-carbalkoxy; and

[0155] R₁ is alkyl, preferably alkyl containing 1 to 3 carbon atoms, more preferably methyl.

[0156] The compounds utilized in the present invention may contain one or more asymmetric carbons and may exist in racemic and optically active forms. The configuration around each asymmetric carbon can be either the D or L form. It is well known in the art that the configuration around a chiral carbon atoms can also be described as R or S in the Cahn-Prelog-Ingold nomenclature system. All of the various configurations around each asymmetric carbon, including the various enantiomers and diastereomers as well as racemic mixtures and mixtures of enantiomers, diastereomers or both are contemplated by the present invention.

[0157] As used herein, the term configuration particularly refers to the configuration around the carbon atom to which R₂ and R₃ or H and R₃ are attached, even though other chiral centers may be present in the molecule. Therefore, when referring to a particular configuration, such as D or L, it is to be understood to mean the D or L stereoisomer at the carbon atom to which R₂ and R₃ or H and R₃ are attached. However, it also includes all possible enantiomers and diastereomers at other chiral centers, if any, present in the compound.

[0158] The compounds of the present invention are directed to all the optical isomers, i.e., the compounds of the present invention are either the L-stereoisomer or the D-stereoisomer (at the carbon atom to which R₂ and R₃ or H and R₃ are attached). These stereoisomers may be found in mixtures of the L and D stereoisomer, e.g., racemic mixtures. The D stereoisomer is preferred.

[0159] It is preferred that the compounds of Formula (I) are in the R configuration. It is also preferred that the compounds of Formula (II) are in the R configuration. It is also preferred that the compounds of Formula (III) are in the R configuration.

[0160] It is preferred that the compounds of Formulae (I), (II) or/and (III) in the R configuration are substantially enantiopure. As used herein, the term "substantially enantiopure" refers to a content of the R enantiomer of at least 99.5%. This corresponds to an enantiomeric excess (ee) of 99%. The respective quantities of R and S enantiomer may be determined by chiral column chromatography, e.g. by HPLC with "ChiralPak" as chiral, stationary phase.

[0161] The term "alkyl" (alone or in combination with another term(s)) means a straight- or branched-chain saturated hydrocarbyl substituent preferably containing from 1 to about 20 carbon atoms (C₁-C₂0-alkyl), more preferably from 1 to about 8 carbon atoms (C₁-C₈-alkyl), even more preferably from 1 to about 6 carbon atoms (C₁-C₆-alkyl), and most preferably from 1 to 3 carbon atoms (C₁-C₃-alkyl). The alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, amyl, hexyl, and the like. Further, alkyl groups also include halogenated alkyl groups up to perhalogenation, e.g. trifluoromethyl, if not indicated otherwise.

[0162] The term "alkoxy" (alone or in combination with another term(s)) refers to --O-alkyl and means a straight- or branched-chain alkoxy substituent preferably containing from 1 to about 20 carbon atoms (C₁-C₂0-alkoxy), more preferably from 1 to about 8 carbon atoms (C₁-C₈-alkoxy), even more preferably from 1 to about 6 carbon atoms (C₁-C₆-alkoxy), and most preferably from 1 to 3 carbon atoms (C₁-C₃-alkoxy). The alkoxy groups include methoxy, ethoxy, propoxy, butoxy, isobutoxy, tert-butoxy, pentoxy, hexoxy and the like. Further, alkoxy groups include halogenated alkoxy groups up to perhalogenation, if not indicated otherwise.

[0163] The term "alkoxyalkyl" refers to an alkyl group substituted with at least one alkoxy group. The alkoxyalkyl groups include methoxymethyl (--CH₂--OCH₃) groups, methoxyethyl (--CH₂--CH₂--OCH₃) groups, ethoxymethyl (--CH₂--O--CH₂CH₃) groups and the like.

[0164] The term "N-alkoxyamino" refers to amino groups substituted with one or two alkoxy groups, e.g. --NH--N(OCH₃)₂.

[0165] The term "N-alkoxy-N-alkylamino" refers to amino groups substituted with an alkoxy group and an alkyl group, e.g. --N(CH₃)(OCH₃), --N(CH₃)(OCH₂--CH₃) and the like.

[0166] The term "N-carbalkoxy" refers to amino groups substituted with a carbalkoxy group, e.g. --NH(C(O)--O--CH₃), --NH(C(O)O--CH₂--CH₃).

[0167] The term "aryl", when used alone or in combination with other term(s), refers to an aromatic group which contains from 6 up to 18 ring carbon atoms (C₆-C₁₈-aryl), preferably from 6 up to 10 ring carbon atoms (C₆-C₁₀-aryl), and includes polynuclear aromatics. The aryl groups may be monocyclic, bicyclic, tricyclic or polycyclic and may be fused rings. A polynuclear aromatic compound as used herein, is meant to encompass bicyclic and tricyclic fused aromatic ring systems containing from 10-18 ring carbon atoms. Aryl groups include phenyl and polynuclear aromatics e.g., naphthyl, anthracenyl, phenanthrenyl, azulenyl and the like. The aryl group also includes groups such as ferrocenyl. Aryl groups may be unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups. A preferred aryl group is phenyl, which may unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups.

[0168] The term "aryl alkyl" as used herein alone or in combination with other term(s) means an alkyl group as defined herein carrying an aryl substitutent as defined herein. Preferred aryl alkyl groups are aryl-C₁-C₆-alkyl, aryl-C₁-C₃-alkyl, C₆-C₁₀-aryl-alkyl, C₆-C₁₀-aryl-C₁-C₆-alkyl, C₆-C₁₀-aryl-C₁-C₃-alkyl. More preferred aryl alkyl groups are phenyl-C₁-C₆-alkyl and phenyl-C₁-C₃-alkyl. Even more preferred aryl alkyl groups include, for example, benzyl, phenylethyl, phenylpropyl, phenylisopropyl, phenylbutyl, diphenylmethyl, 1,1-diphenylethyl, 1,2-diphenylethyl, and the like. Most preferred is benzyl.

[0169] The term "alkenyl" (alone or in combination with another term(s)) means a straight- or branched-chain alkenyl substituent containing at least one double bond and preferably containing from 2 to about 20 carbon atoms (C₂-C₂0-alkenyl), more preferably from 2 to about 8 carbon atoms (C₂-C₈-alkenyl), and even more preferably from 2 to about 6 carbon atoms (C₂-C₆-alkenyl), most preferably 2 or 3 carbon atoms (C₂-C₃-alkenyl). The alkenyl group may be in the Z or E form. Alkenyl groups include vinyl, propenyl, 1-butenyl, isobutenyl, 2-butenyl, 1-pentenyl, (Z)-2-pentenyl, (E)-2-pentenyl, (Z)-4-methyl-2-pentenyl, (E)-4-methyl-2-pentenyl, pentadienyl, e.g., 1, 3 or 2,4-pentadienyl, and the like.

[0170] The term "alkynyl" (alone or in combination with another term(s)) means a straight- or branched-chain alkynyl substituent containing at least one triple bond and preferably containing from 2 to about 20 carbon atoms (C₂-C₂0-alkynyl), more preferably from 2 to about 8 carbon atoms (C₂-C₈-alkynyl), and even more preferably from 2 to about 6 carbon atoms (C₂-C₆-alkynyl), most preferably 2 or 3 carbon atoms (C₂-C₃-alkynyl). The alkynyl group includes ethynyl, propynyl, 1-butynyl, 2-butynyl, 1-pentynyl, 2-pentynyl, 3-methyl-1-pentynyl, 3-pentynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl and the like.

[0171] The term "cycloalkyl" when used alone or in combination with another term(s) means a cycloalkyl group containing from 3 to 18 ring carbon atoms (C₃-C₁₈-cycloalkyl), preferably from 6 up to 10 ring carbon atoms (C₃-C₁₀-cycloalkyl). The cycloalkyl groups may be monocyclic, bicyclic, tricyclic, or polycyclic, and the rings may be fused. The cycloalkyl may be completely saturated or partially saturated. Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclodecyl, cyclohexenyl, cyclopentenyl, cyclooctenyl, cycloheptenyl, decalinyl, hydroindanyl, indanyl, fenchyl, pinenyl, adamantyl, and the like. The cycloalkyl group includes the cis or trans forms. Cycloalkyl groups may be unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups. In a bridged bicyclic cycloalkyl group, the substituents may either be in endo or exo positions.

[0172] The term "cycloalkyl alkyl" as used herein alone or in combination with other term(s) means an alkyl group as defined herein carrying a cycloalkyl substitutent as defined herein. Preferred cycloalkyl alkyl groups are cycloalkyl-C₁-C₆-alkyl, cycloalkyl-C₁-C₃-alkyl, C₆-C₁₀-cycloalkyl-alkyl, C₆-C₁₀-cycloalkyl-C₁-C₆-alkyl, C₆-C₁₀-cycloalkyl-C₁-C₃-alkyl. A more preferred cycloalkyl alkyl group is selected from cyclohexyl-C₁-C₆-alkyl and cyclohexyl-C₁-C₃-alkyl.

[0173] The term "halo" or "halogen" includes fluoro, chloro, bromo, and iodo.

[0174] The prefix "halo" indicates that the substituent to which the prefix is attached is substituted with one or more independently selected halogen radicals. For example, haloalkyl means an alkyl substituent wherein at least one hydrogen radical is replaced with a halogen radical. Examples of haloalkyls include chloromethyl, 1-bromoethyl, fluoromethyl, difluoromethyl, trifluoromethyl, 1,1,1-trifluoroethyl, and the like. Illustrating further, "haloalkoxy" means an alkoxy substituent wherein at least one hydrogen radical is replaced by a halogen radical. Examples of haloalkoxy substituents include chloromethoxy, 1-bromoethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy (also known as "perfluoromethyloxy"), 1,1,1,-trifluoroethoxy, and the like. It should be recognized that if a substituent is substituted by more than one halogen radical, those halogen radicals may be identical or different (unless otherwise stated).

[0175] The terms "electron-withdrawing" and "electron donating" refer to the ability of a substituent to withdraw or donate electrons, respectively, relative to that of hydrogen if the hydrogen atom occupied the same position in the molecule. These terms are well understood by one skilled in the art and are discussed in Advanced Organic Chemistry, by J. March, John Wiley and Sons, New York, N.Y., pp. 16-18 (1985) and the discussion therein is incorporated herein by reference. Electron withdrawing groups include halo, including bromo, fluoro, chloro, iodo; nitro, carboxy, alkenyl, alkynyl, formyl, carboxyamido, aryl, quaternary ammonium, haloalkyl such as trifluoromethyl, aryl alkanoyl, carbalkoxy and the like. Electron donating groups include such groups as hydroxy, alkoxy, including methoxy, ethoxy and the like; alkyl, such as methyl, ethyl, and the like; amino, alkylamino, dialkyl amino, aryloxy such as phenoxy, mercapto, alkylthio, alkylmercapto, disulfide (alkyldithio) and the like. One of ordinary skill in the art will appreciate that some of the aforesaid substituents may be considered to be electron donating or electron withdrawing under different chemical conditions. Moreover, the present invention contemplates any combination of substituents selected from the above-identified groups.

[0176] The electron donating or/and electron withdrawing groups may independently be present in any one of the substituents in Formula (I), (II) or/and (III) e.g., in R, R₁, R₂, R₃, R₄, R₅, R₆, R'₆, R₇, R₈, R₉ or/and R₁₀ as defined herein.

[0177] The at least one electron withdrawing or/and at least one electron donating group is preferably selected independently from halo, alkyl, alkenyl, alkynyl, nitro, carboxy, formyl, carboxyamido, aryl, quaternary ammonium, haloalkyl, aryl alkanoyl, hydroxy, alkoxy, carbalkoxy, amino, alkylamino, dialkylamino, aryloxy, mercapto, alkylthio, alkylmercapto, disulfide, alkanoyl, amino alkyl, aryloyl, cyano, sulfonyl, sulfoxide, heterocyclic, guanidine, sulfonium salts, mercaptoalkyl, and alkyldithio.

[0178] The term "sulfide" encompasses mercapto, mercapto alkyl and alkylthio, while the term disulfide encompasses alkyldithio.

[0179] In the compounds of the present invention, the at least one electron withdrawing or/and at least one electron donating group is more preferably selected independently from halo, alkyl, alkenyl, alkynyl, nitro, carboxy, formyl, carboxyamido, aryl, quaternary ammonium, haloalkyl, aryl alkanoyl, hydroxy, alkoxy, carbalkoxy, amino, alkylamino, dialkylamino, aryloxy, mercapto, alkylthio, alkylmercapto, and disulfide.

[0180] Even more preferably, the at least one electron withdrawing or/and at least one electron donating group is selected from halo, C₁-C₆-alkyl, C₂-C₆-alkenyl, C₁-C₆-alkynyl, nitro, carboxy, formyl, carboxyamido, C₆-C₁₀-aryl, quaternary ammonium, C₁-C₆-haloalkyl, C₆-C₁₀-aryl C₂-C₆-alkanoyl, hydroxy, C₁-C₆-alkoxy, C₂-C₆-carbalkoxy, amino, C₁-C₆-alkylamino, C₁-C₆-dialkylamino, C₆-C₁₀-aryloxy, mercapto, C₁-C₆-alkylthio, C₁-C₆-alkylmercapto, and disulfide.

[0181] Even more preferably, the electron withdrawing or/and electron donating groups may also be independently selected from halo, C₁-C₆-alkoxy, nitro, carboxy, formyl, carboxyamido, quaternary ammonium, hydroxy, amino, mercapto, and disulfide.

[0182] Most preferred electron withdrawing or/and electron donating groups are independently selected from halo such as fluoro and C₁-C₆-alkoxy such as methoxy and ethoxy.

[0183] The term "carbalkoxy" as used herein alone or in combination with other term(s) means an --CO--O-alkyl, wherein alkyl is as defined herein, taking into account that the --CO--O-group provides one carbon atom in addition to those of the alkyl group. The carbalkoxy group preferably contains from 2 to about 20 carbon atoms (C₂-C₂0-carbalkoxy), more preferably from 2 to about 8 carbon atoms (C₂-C₈-carbalkoxy), even more preferably from 2 to about 6 carbon atoms (C₂-C₆-carbalkoxy), and most preferably from 2 to 3 carbon atoms (C₂-C₃-carbalkoxy).

[0184] The term "alkanoyl" as used herein alone or in combination with other term(s) means an alkanoyl group --CO-alkyl, wherein alkyl is as defined herein, taking into account that the --CO-- group provides one carbon atom in addition to those of the alkyl group. The alkanoyl preferably contains from 2 to about 20 carbon atoms (C₂-C₂0-alkanoyl), more preferably from 2 to about 8 carbon atoms (C₂-C₈-alkanoyl), even more preferably from 2 to about 6 carbon atoms (C₂-C₆-alkanoyl), and most preferably from 2 to 3 carbon atoms (C₂-C₃-alkanoyl). The alkanoyl group may be straight chained or branched. The alkanoyl groups include, for example, formyl, acetyl, propionyl, butyryl, isobutyryl, tertiary butyryl, pentanoyl and hexanoyl.

[0185] As employed herein, a heterocyclic group contains at least one heteroatom in the cyclic structure, preferably one, two, three or four heteroatoms. The at least one heteroatom may be independently selected from sulfur, nitrogen and oxygen. The heterocyclic groups contemplated by the present invention include heteroaromatics and saturated and partially saturated heterocyclic groups. The heterocyclics may be monocyclic, bicyclic, tricyclic or polycyclic and may be fused rings. The heterocyclics also include the so-called benzoheterocyclics. Heterocyclic groups may be unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups. The heterocyclic groups preferably contain up to 18 ring atoms and up to a total of 17 ring carbon atoms and may be unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups.

[0186] More preferably, the heterocyclic group may be independently selected from 5 or 6-membered monocyclic heterocyclic groups and may be unsubstituted or mono or polysubstituted with electron withdrawing or/and electron donating groups. The heterocyclic group may also be more preferably selected independently from furyl, thienyl, pyrazolyl, pyrrolyl, methylpyrrolyl, imidazolyl, indolyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, piperidyl, pyrrolinyl, piperazinyl, quinolyl, triazolyl, tetrazolyl, isoquinolyl, benzofuryl, benzothienyl, morpholinyl, benzoxazolyl, tetrahydrofuryl, pyranyl, indazolyl, purinyl, indolinyl, pyrazolindinyl, imidazolinyl, imadazolindinyl, pyrrolidinyl, furazanyl, N-methylindolyl, methylfuryl, pyridazinyl, pyrimidinyl, pyrazinyl, pyridyl, epoxy, aziridino, oxetanyl, azetidinyl, the N-oxides of the nitrogen containing heterocycles, such as the N-oxides of pyridyl, pyrazinyl, and pyrimidinyl and the like. Even more preferably, the heterocyclic moieties are those aforementioned heterocyclics which are monocyclic.

[0187] The heterocyclics may also be more preferably selected independently from thienyl, furyl, pyrrolyl, benzofuryl, benzothienyl, indolyl, oxazolyl, methylpyrrolyl, morpholinyl, pyridiyl, pyrazinyl, imidazolyl, pyrimidinyl, and pyridazinyl. Especially preferred heterocyclic are independently selected from furyl, oxazolyl, pyridyl, pyrazinyl, imidazolyl, pyrimidinyl, and pyridazinyl. The most preferred heterocyclics are independently selected from furyl, pyridyl and oxazolyl.

[0188] The monocyclic 5- or 6-membered heterocyclic groups in the compounds of the present invention are preferably of the Formula (IV):

##STR00005##

or those corresponding partially or fully saturated form thereof, wherein n is 0 or 1; and

[0189] R₅₀ is H, an electron withdrawing group or an electron donating group;

[0190] A, E, L, J and G are independently CH, or a heteroatom selected from the group consisting of N, O, S; but when n is 0, G is CH, or a heteroatom selected from the group consisting of NH, O and S with the proviso that at most two of A, E, L, J and G are heteroatoms.

[0191] When n is 0, the above heteroaromatic moiety is a five membered ring, while if n is 1, the heterocyclic moiety is a six membered monocyclic heterocyclic moiety.

[0192] If the ring depicted in Formula (IV) contains a nitrogen ring atom, then the N-oxide forms are also contemplated to be within the scope of the invention.

[0193] When R₂ or R₃ is a heterocyclic of Formula (IV), it may be bonded to the main chain by a ring carbon atom. When n is 0, R₂ or R₃ may additionally be bonded to the main chain by a nitrogen ring atom.

[0194] The term "heterocyclic alkyl" as used herein alone or in combination with other term(s) means an alkyl group as defined above carrying a heterocyclic substituent as defined above. Preferred heterocyclic alkyl groups are heterocyclic-C₁-C₆-alkyl, heterocyclic-C₁-C₃-alkyl, wherein the heterocyclic may be a preferred, more preferred or most preferred heterocyclic group as defined herein.

[0195] The term "alkyl heterocyclic" as used herein alone or in combination with other term(s) means a heterocyclic group as defined above carrying at least one alkyl substituent as defined above. Preferred alkyl heterocyclic groups are C₁-C₆-alkyl-heterocyclic, C₁-C₃-alkyl-heterocyclic, wherein the heterocyclic group may be a preferred, more preferred or most preferred heterocyclic group as defined herein.

[0196] The preferred compounds are those wherein n is 1, but di (n=2), tri (n=3) and tetrapeptides (n=4) are also contemplated to be within the scope of the invention.

[0197] In the ZY groups representative of R₂ or/and R₃, in the formula (I) or/and (II), Z may be O, S, S(O)_a, wherein a is 1-3, NR₄, NR'₆, PR₄ or a chemical bond; and Y may be hydrogen, alkyl, aryl, aryl alkyl, alkenyl, alkynyl, halo, heterocyclic, heterocyclic alkyl, alkyl heterocyclic, and Y may be unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group, provided that when Y is halo, Z is a chemical bond, or

[0198] ZY taken together may be NR₄NR₅R₇, NR₄OR₅, ONR₄R₇, OPR₄R₅, PR₄OR₅, SNR₄R₇, NR₄SR₇, SPR₄R₅, PR₄SR₇, NR₄PR₅R₆, PR₄NR₅R₇ or N⁺R₅R₆R₇,

##STR00006##

wherein R₄, R₅, R'₆, R₆, R₇, are as defined herein.

[0199] The ZY groups representative of R₂ or/and R₃ in the Formula (I) or/and (II) may be hydroxy, alkoxy, such as methoxy, ethoxy, aryloxy, such as phenoxy; thioalkoxy, such as thiomethoxy, thioethoxy; thioaryloxy such as thiophenoxy; amino; alkylamino, such as methylamino, ethylamino; arylamino, such as anilino; dialkylamino, such as, dimethylamino; trialkyl ammonium salt, hydrazino; alkylhydrazino and arylhydrazino, such as N-methylhydrazino, N-phenylhydrazino, carbalkoxy hydrazino, aralkoxycarbonyl hydrazino, aryloxycarbonyl hydrazino, hydroxylamino, such as N-hydroxylamino (--NH--OH), alkoxy amino [(NHOR₁₈) wherein R₁₈ is alkyl], N-alkylhydroxylamino [(NR₁₈)OH wherein R₁₈ is alkyl], N-alkyl-O-alkylhydroxyamino, i.e., [N(R₁₈)OR₁9 wherein R₁₈ and R₁9 are independently alkyl], and O-hydroxylamino (--O--NH₂); alkylamido such as acetamido; trifluoroacetamido; alkoxyamino, (e.g., NH(OCH₃); and heterocyclicamino, such as pyrazoylamino.

[0200] In a preferred ZY group, Z is O, NR₄ or PR₄; Y is hydrogen or alkyl.

[0201] In another preferred embodiment,

[0202] ZY is NR₄R₅R₇, NR₄OR₅, ONR₄R₇,

##STR00007##

[0203] In a more preferred that ZY is NR₄OR₅, or ONR₄R₇.

[0204] Another more preferred ZY is N-hydroxyamino, N-alkylhydroxyamino, N-alkyl-O-alkyl hydroxyamino, O-alkylhydroxyamino, N-alkoxy-N-alkylamino, N-alkoxyamino, or N-carbalkoxy.

[0205] In Formula (I), R is preferably aryl or aryl alkyl, more preferably R is aryl alkyl, wherein R is unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group. R may be phenyl or benzyl, most preferably benzyl, wherein R is unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group. If R is substituted, R is preferably substituted on the aryl ring. In this embodiment, the at least one electron donating group or/and at least one electron withdrawing group is preferably halo, more preferably fluoro.

[0206] In Formulae (I), (II) or/and (III), R₁ is H or alkyl. More preferably, R₁ is alkyl, preferably containing from 1 to 6 carbon atoms, more preferably containing from 1 to 3 carbon atoms. Most preferably the R₁ group is methyl. R₁ may be unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group.

[0207] Further, it is preferred that one of R₂ and R₃ is hydrogen. It is more preferred that R₂ is hydrogen. Other preferred moieties of R₂ in Formula (I) are aryl such as phenyl, aryl alkyl such as benzyl, and alkyl. It is to be understood that the preferred groups of R₂ may be unsubstituted or mono or poly substituted with electron donating or/and electron withdrawing groups. It is preferred that the at least one electron withdrawing or/and at least one donating group in R₂ is independently alkoxy, N-hydroxyamino, N-alkylhydroxyamino, N-alkyl-O-alkyl hydroxyamino or O-alkylhydroxyamino, and especially methoxy or ethoxy.

[0208] In Formulae (I), (II) or/and (III), R₃ may be hydrogen, an alkyl group unsubstituted or substituted by at least an electron donating or/and at least one electron withdrawing group, an aryl group unsubstituted or substituted by at least an electron donating or/and at least one electron withdrawing group heterocyclic, heterocyclic alkyl, or ZY.

[0209] It is preferred that R₃ is hydrogen, alkyl unsubstituted or substituted by at least an electron donating or/and at least one electron withdrawing group, aryl which is unsubstituted or substituted by at least one electron donating group or/and at least one electron withdrawing group, heterocyclic, heterocyclic alkyl or ZY, wherein Z is O, NR₄ or PR₄; Y is hydrogen or alkyl;

##STR00008##

[0210] ZY is NR₄NR₅R₇, NR₄OR₅, ONR₄R₇,

[0211] It is also preferred that R₃ is alkyl unsubstituted or substituted by at least an electron donating or/and at least one electron withdrawing group; or Z--Y, wherein Z--Y is as defined herein.

[0212] It is also preferred that R₃ is alkyl unsubstituted or substituted by at least an electron donating or/and at least one electron withdrawing group; NR₄OR₅, or ONR₄R₇, wherein R₄, R₅ and R₇ are as defined herein.

[0213] It is also preferred that R₃ is CH₂-Q, wherein Q is alkoxy especially containing 1-3 carbon atoms; or R₃ is NR₄OR₅ or ONR₄R₇, wherein R₄, R₅, and R₇ are as defined herein.

[0214] R₃ is also preferably alkyl which is unsubstituted or substituted with at least one alkoxy especially containing 1-3 carbon atoms.

[0215] R₃ is also preferably CH₂-Q, wherein Q is alkoxy preferably containing 1-3 carbon atoms, more preferably Q is ethoxy or methoxy.

[0216] R₃ is also preferably NR₄OR₅, or ONR₄R₇, wherein R₄, R₅ and R₇ are as defined herein, and R₄, R₅ and R₇ are as defined herein, e.g. N-alkoxy, N-alkoxy-N-alkylamino or N-carbalkoxy.

[0217] R₃ is also preferably heterocyclic, heterocyclic alkyl, or aryl, which may be unsubstituted or substituted with at least an electron donating or/and at least one electron withdrawing group. A most preferred heterocyclic in R₃ is furyl or oxazolyl.

[0218] R₃ is also preferably selected from the group consisting of hydrogen, alkyl, arylalkyl such as benzyl, alkoxy, alkoxyalkyl, aryl such as phenyl, heterocyclic, heterocyclic alkyl, N-alkoxy-N-alkylamino, N-alkoxyamino and N-carbalkoxy.

[0219] It is to be understood that the preferred groups of R₃ may be unsubstituted or mono or poly substituted with electron donating or/and electron withdrawing groups. It is preferred that the at least one electron withdrawing or/and at least one electron donating group in R₃ is independently alkoxy, N-hydroxyamino, N-alkylhydroxyamino, N-alkyl-O-alkyl hydroxyamino or O-alkylhydroxyamino, and especially methoxy or ethoxy.

[0220] R₄, R₅, R₆, R'₆, R₇ and R₈ are preferably independently hydrogen or alkyl.

[0221] R₄, R₅, and R₇ are preferably independently hydrogen or alkyl preferably containing 1-3 carbon atoms.

[0222] The most preferred aryl is phenyl. The most preferred halo is fluoro.

[0223] In the compounds of Formula (I), R is preferably aryl alkyl, wherein R is unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group.

[0224] In the compounds of Formula (I), R₁ is preferably alkyl which is unsubstituted or substituted with at least one electron donating group or/and at least one electron withdrawing group.

[0225] In the compounds of Formula (I), R₂ and R₃ is preferably independently hydrogen, alkyl which is unsubstituted or substituted by at least one electron donating group or/and at least one electron withdrawing group, aryl which is unsubstituted or substituted by at least one electron donating group or/and at least one electron withdrawing group, heterocyclic, heterocyclic aryl, or ZY; wherein Z is O, NR₄ or PR₄; and Y is hydrogen or alkyl; or ZY is NR₄NR₅R₇, NR₄OR₅, ONR₄R₇,

##STR00009##

wherein R₄, R₅ and R₇ are as defined herein.

[0226] In the compounds of Formula (I), the preferred groups of R₂ and R₃ may be unsubstituted or mono or poly substituted with electron donating or/and electron withdrawing groups, such as alkoxy (e.g., methoxy, ethoxy, and the like), N-hydroxyamino, N-alkylhydroxyamino, N-alkyl-O-alkyl hydroxyamino and O-alkylhydroxyamino.

[0227] In the compounds of Formula (I), the at least one electron donating group or/and at least one electron withdrawing group in R₂ or/and R₃ is preferably independently hydroxy or alkoxy.

[0228] It is more preferred that in the compounds of Formula (I), R₂ is hydrogen.

[0229] In the compounds of Formula (II), R₁ is preferably methyl.

[0230] In preferred compounds of Formula (II), R₃ is hydrogen or alkyl unsubstituted or substituted by at least one electron donating group or/and at least one electron withdrawing group; or R₃ is heterocyclic, heterocyclic alkyl, or Z--Y, wherein Z--Y and heterocyclic are as defined herein.

[0231] In other preferred compounds of Formula (II), R₃ is an alkyl group which is unsubstituted or substituted by at least one electron donating group or/and at least one electron withdrawing group, NR₄OR₅ or ONR₄R₇, wherein R₄, R₅ and R₇ are as defined herein and wherein the at least one electron donating group or/and at least one electron withdrawing group is preferably selected from hydroxy and alkoxy.

[0232] In further preferred compounds of Formula (II), R₃ is CH₂-Q, wherein Q is alkoxy preferably containing 1-3 carbon atoms, more preferably methoxy, or R₃ is NR₄OR₅ or ONR₄R₇ wherein R₄, R₅ and R₇ are independently hydrogen or alkyl containing 1-3 carbon atoms.

[0233] In other preferred compounds of Formula (II), R₃ is --CH₂-Q, wherein Q is alkoxy containing 1 to 3 carbon atoms.

[0234] In the compounds of Formula (II), Ar is preferably phenyl unsubstituted or substituted with at least one halo, preferably with at least one fluoro. More preferably Ar in Formula (II) is unsubstituted phenyl.

[0235] In preferred compounds of Formula (III), R₉ is hydrogen or fluoro, R₃ is selected from the group consisting of methoxymethyl, phenyl, N-methoxy-N-methylamino, and N-methoxyamino, and R₁ is methyl.

[0236] The most preferred compounds of the present invention include:

[0237] (R)-2-acetamido-N-benzyl-3-methoxy-propionamide;

[0238] (R)-2-acetamido-N-benzyl-3-ethoxy-propionamide;

[0239] O-methyl-N-acetyl-D-serine-m-fluorobenzyl-amide;

[0240] O-methyl-N-acetyl-D-serine-p-fluorobenzyl-amide;

[0241] N-acetyl-D-phenylglycine benzylamide;

[0242] D-1,2-(N,O-dimethylhydroxylamino)-2-acetamide acetic acid benzylamide;

[0243] D-1,2-(O-methylhydroxylamino)-2-acetamido acetic acid benzylamide;

[0244] D-α-acetamido-N-(2-fluorobenzyl)-2-furanacetamide;

[0245] D-α-acetamido-N-(3-fluorobenzyl)-2-furanacetamide.

[0246] It is to be understood that the Markush groups of R₁, R₂, R₃, R and n as described herein can be combined and permutated. The various combinations and permutations not explicitly disclosed herein are contemplated to be within the scope of the present invention. Moreover, the present invention also encompasses compounds and compositions which contain one or more elements of each of the Markush groupings in R₁, R₂, R₃, n and R and the various combinations thereof. Thus, for example, the present invention contemplates that R₁ may be one or more of the substituents listed hereinabove in combination with any and all of the substituents of R₂, R₃, and R with respect to each value of n.

[0247] More preferred is a compound of Formula (I), (II) or/and (III) in the R configuration, preferably substantially enantiopure, wherein the substituent R is benzyl which is unsubstituted with at least one halo group, wherein R₃ is CH₂-Q, wherein Q is alkoxy containing 1-3 carbon atoms and wherein R₁ is methyl. Preferably R is unsubstituted benzyl or benzyl substituted with at least one halo group which is a fluoro group.

[0248] Depending upon the substituents, the present compounds may form addition salts as well. All of these forms are contemplated to be within the scope of this invention including mixtures of the stereoisomeric forms.

[0249] The manufacture of compounds utilized in the present invention is described in U.S. Pat. Nos. 5,378,729 and 5,773,475, and in the international application PCT/EP 2005/010603 the contents of which are incorporated by reference.

[0250] The compounds utilized in the present invention are useful as such as depicted in the Formulae (I), (II) or/and (III) or can be employed in the form of salts in view of its basic nature by the presence of the free amino group. Thus, the compounds of Formulae (I), (II) or/and (III) form salts with a wide variety of acids, inorganic and organic, including pharmaceutically acceptable acids. The salts with therapeutically acceptable acids are of course useful in the preparation of formulation where enhanced water solubility is most advantageous.

[0251] These pharmaceutically acceptable salts have also therapeutic efficacy. These salts include salts of inorganic acids such as hydrochloric, hydroiodic, hydrobromic, phosphoric, metaphosphoric, nitric acid and sulfuric acids as well as salts of organic acids, such as tartaric, acetic, citric, malic, benzoic, perchloric, glycolic, gluconic, succinic, aryl sulfonic, (e.g., p-toluene sulfonic acids, benzenesulfonic), phosphoric, malonic, and the like.

[0252] The physician will determine the dosage of the present therapeutic agents which will be most suitable and it will vary with the form of administration and the particular compound chosen, and furthermore, it will vary with the patient under treatment, the age of the patient, the type of malady being treated. He will generally wish to initiate treatment with small dosages substantially less than the optimum dose of the compound and increase the dosage by small increments until the optimum effect under the circumstances is reached. When the composition is administered orally, larger quantities of the active agent will be required to produce the same effect as a smaller quantity given parenterally. The compounds are useful in the same manner as comparable therapeutic agents and the dosage level is of the same order of magnitude as is generally employed with these other therapeutic agents.

[0253] In one embodiment, the compounds of the present invention are administered in amounts ranging from about 1 mg to about 100 mg per kilogram of body weight per day, or in amounts ranging from about 1 mg to about 10 mg per kilogram of body weight per day. This dosage regimen may be adjusted by the physician to provide the optimum therapeutic response. Patients in need thereof may be treated with doses of the compound of the present invention of at least 50 mg/day, of at least 200 mg/day, of at least 300 mg/day, of at least 400 mg/day, or of at least 600 mg/day. Generally, a patient in need thereof may be treated with doses at a maximum of 6 g/day, a maximum of 1 g/day, a maximum of 800 mg/day, or a maximum of 600 mg/day. In some cases, however, higher or lower doses may be needed.

[0254] In another embodiment, the daily doses are increased until a predetermined daily dose is reached which is maintained during the further treatment.

[0255] In yet another embodiment, several divided doses may be administered daily. For example, three doses per day, or two doses per day, or a single dose per day may be administered.

[0256] In yet another embodiment, an amount of the compounds of the present invention may be administered which results in a plasma concentration of 0.1 to 15 μg/ml (trough) and 5 to 18.5 μg/ml (peak), calculated as an average over a plurality of treated subjects, intravenous administration in emergency treatment might result in peak plasmid levels of up to 30 μg/ml.

[0257] The compounds of Formulae (I), (II) or/and (III) may be administered in a convenient manner, such as by oral, intravenous (where water soluble), intramuscular, intrathecal, rectal (e.g. suppository, gel, liquid, etc.) or subcutaneous routes. In particular, the compounds of Formulae (I), (II) or/and (III) may be administered orally, rectally or/and i.v. In emergency treatment, the compounds of Formulae (I), (II) or/and (III) may be i.v. administered.

[0258] The pharmaceutical composition of the present invention may be prepared for the treatment regimen as described above, in particular for the treatment with doses as described above, to effect plasma concentrations as described above, for administration periods or/and administration routes as specified in the embodiments of the present invention as described above.

[0259] The compounds of Formulae (I), (II) or/and (III) may be orally administered, for example, with an inert diluent or with an assimilable edible carrier, or it may be enclosed in hard or soft shell gelatin capsules, or it may be compressed into tablets, or it may be incorporated directly into the food of the diet. For oral therapeutic administration, the active compound of Formulae (I), (II) or/and (III) may be incorporated with excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like. Such compositions and preparations should contain at least 1% of active compound of Formulae (I), (II) or/and (III). The percentage of the compositions and preparations may, of course, be varied and may conveniently be between about 5 to about 80% of the weight of the unit. The amount of active compound of Formulae (I), (II) or/and (III) in such therapeutically useful compositions is such that a suitable dosage will be obtained. The compositions or preparations according to the present invention may contain between about 10 mg and 6 g active compound of Formulae (I), (II) or/and (III).

[0260] The tablets, troches, pills, capsules and the like may also contain the following: A binder such as gum tragacanth, acacia, corn starch or gelatin; excipients such as dicalcium phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid and the like; a lubricant such as magnesium stearate; and a sweetening agent such as sucrose, lactose or saccharin may be added or a flavoring agent such as peppermint, oil of wintergreen, or cherry flavoring. When the dosage unit form is a capsule, it may contain, in addition to materials of the above type, a liquid carrier.

[0261] Various other materials may be present as coatings or otherwise modify the physical form of the dosage unit. For instance, tablets, pills, or capsules may be coated with shellac, sugar or both. A syrup or elixir may contain the active compound, sucrose as a sweetening agent, methyl and propylparabens as preservatives, a dye and flavoring such as cherry or orange flavor. Of course, any material used in preparing any dosage unit form should be pharmaceutically pure and substantially non-toxic in the amounts employed. In addition, the active compound may be incorporated into sustained-release preparations and formulations. For example, sustained release dosage forms are contemplated wherein the active ingredient is bound to an ion exchange resin which, optionally, can be coated with a diffusion barrier coating to modify the release properties of the resin.

[0262] The active compound may also be administered parenterally or intraperitoneally. Dispersions can also be prepared in glycerol, liquid, polyethylene glycols, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.

[0263] The pharmaceutical forms suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases the form must be sterile and must be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersions and by the use of surfactants. The prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride. Prolonged absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminium monostearate and gelatin.

[0264] Sterile injectable solutions are prepared by incorporating the active compound in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilized active ingredient into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above. In the case of preparing sterile powders for the manufacture of sterile injectable solutions, the preferred methods of preparation are vacuum drying, or freeze-drying optionally together with any additional desired ingredient.

[0265] As used herein, "pharmaceutically acceptable carrier" includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agent, isotonic and absorption delaying agents for pharmaceutical active substances as well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated. Supplementary active ingredients can also be incorporated into the compositions.

[0266] It is especially advantageous to formulate parenteral compositions in dosage unit form or ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the mammalian subjects to be treated; each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specifics for the novel dosage unit forms of the invention are dictated by and directly dependent on (a) the unique characteristics of the active material an the particular therapeutic effect to be achieved, and (b) the limitations inherent in the art of compounding such as active material for the treatment of disease in living subjects having a diseased condition in which bodily health is impaired as herein disclosed in detail.

[0267] The principal active ingredient is compounded for convenient and effective administration in effective amounts with a suitable pharmaceutically acceptable carrier in dosage unit form as hereinbefore described. A unit dosage form can, for example, contain the principal active compound in amounts ranging from about 10 mg to about 6 g. Expressed in proportions, the active compound is generally present in from about 1 to about 750 mg/ml of carrier. In the case of compositions containing supplementary active ingredients, the dosages are determined by reference to the usual dose and manner of administration of the said ingredients.

[0268] As used herein the term "patient" or "subject" refers to a warm blooded animal, and preferably mammals, such as, for example, cats, dogs, horses, cows, pigs, mice, rats and primates, including humans. The preferred patient is a human.

[0269] The term "treat" refers to either relieving the pain associated with a disease or condition, or to providing partial to complete relief of the patient's disease or condition or to alleviating the patient's disease or condition.

[0270] The compounds of the present invention are administered to a patient suffering from the aforementioned type of disorder in an effective amount. These amounts are equivalent to the therapeutically effective amounts described hereinabove.

EXAMPLES

[0271] The present invention is further illustrated by the following example and figures.

FIGURE LEGENDS

[0272] FIG. 1A: Fraction of channels available after a repolarizing pulse of -100 mV and -60 mV, respectively. LTG: lamotrigine, CBZ: carbamazepine, DPH: phenyloin, LCM: lacosamide.

[0273] FIG. 1B: Voltage dependency of slow inactivation in the presence (LCM) or in the absence (PRETREATMENT) of lacosamide. Cells were held at -80 mV and depolarised for 10 seconds to -10 mV, followed by a recovery interval of 1.5 s prior to a test pulse. The recovery interval of 1.5 s was used to completely allow the recovery of fast inactivation making occupancy of the slow inactivated state the sole determinant of the second test pulse amplitude. The test pulse was used to measure the peak available current.

[0274] FIG. 2: Effect of chlordiazepoxide (CDP), pregabalin and lacosamide (LCM, 3-30 mg/kg) on SIH. Data represents mean±SEM of 11-12 mice/treatment group. *: significantly different from saline, P<0.05.

[0275] FIGS. 3 and 4: The effects of lacosamide on neuronal damage in CA1-CA3 after glutamate exitotoxicity (Glut). 2 h before Glut (15 mM for 24 h) cultures were treated with vehicle (Glut), 10 μM MK-801, 1 μM Tetrodotoxin (TTX), 1 μM (S1), 10 μM (S2) and 100 μM (S3) of lacosamide. Compounds were present from 2 h before until 24 h after Glut onset. Neuronal damage was assessed by densitometric quantification of propidium-iodide (PI) uptake (FIG. 3) or by colorimetric quantification of LDH release (FIG. 4) 24 h after Glut onset. Glut damage was set to 100%, data are given as % of Glut damage. Data were combined from 2-4 independent experiments Data are given as mean value plus STD (***p<0.001 vs Glut; **p<0.01 vs Glut. Tukey test post hoc after 1-way ANOVA).

[0276] FIG. 5: Lacosamide shifts the slow inactivation voltage curve to more hyperpolarized membrane potentials in Xenopus oocytes expressing the alpha subunit of the Rat Type II Sodium Channel (FIG. 5A). In rat dorsal root ganglia, Lacosamide at 100 μM increases the maximal fraction of slowly inactivated TTX-resistant sodium current (FIG. 5B). Lacosamide did not delay recovery from slow inactivation (FIG. 5C).

Example 1

[0277] Initial studies indicated that lacosamide does not produce changes to the processes of fast inactivation gating of sodium channels in a manner that was consistent with the effects of existing antiepileptic drugs. This was evidenced by a very limited effect of lacosamide upon action potential firing evoked by brief depolarising steps or ramps. The lack of effect of lacosamide upon fast inactivation has been further supported by experiments performed upon Xenopus oocytes expressing only sodium channel alpha subunits. Again, as was observed in neuroblastoma cells, lacosamide did not produce shifts in the fast inactivation voltage curve or retard recovery from steady state fast inactivation. Contrary to the lack of effect of lacosamide, both of these gating processes were considerably changed by carbamazepine, lamotrigine and phenyloin.

[0278] In the oocyte expression system lacosamide was however, still able to produce rapid and profoundly voltage dependent inhibition of sodium currents. Sodium channels in mouse neuroblastoma N1E-115 cells undergo the physiological process of slow inactivation in addition to fast inactivation when exposed to periods of prolonged depolarisation. Sodium channels in the fast inactivated conformation can be reactivated by a 500 ms hyperpolarizing pulse. A following test pulse will reveal selectively the amount of slow inactivated sodium channels.

[0279] Thus neuroblastoma cells were maintained at a holding potential of -60 mV to induce fast and slow inactivation and depolarised by a 10 ms test pulse to 0 mV to measure the amount of available channels. This protocol was repeated in each cell with a 500 ms hyperpolarizing pulse to -100 mV prior to the depolarising test pulse in order to selectively remove fast inactivation. In all cells tested carbamazepine (CBZ), lamotrigine (LTG), phenyloin (DPH) and lacosamide (LCM, all drugs tested at 100 μM) produced a reduction in current when the holding potential was -60 mV. For CBZ, LTG and DPH application of a 500 ms hyperpolarizing pulse to -100 mV reversed the blocking action on the channel, with the fraction available being 0.94±0.19, 0.88±0.06 and 0.99±0.05 respectively compared to control values (FIG. 1A).

[0280] In comparison to the results of the clinically used sodium channel modulating anticonvulsants, the inhibition produced by LCM was not altered by the hyperpolarizing prepulse i.e. by the removal of fast inactivation. This indicates that whereas the classical sodium channel modulating anticonvulsants lamotrigine, carbamazepine and phenyloin selectively act on fast inactivation, lacosamide exerts its effects on sodium currents exclusively by enhancing slow inactivation.

[0281] In order to assess concentration-dependent effects of lacosamide on the entry of sodium channels into the slow inactivated state, cells were held at -80 mV and depolarised for 10 seconds to -10 mV, followed by a recovery interval of 1.5 s prior to a test pulse to measure the peak available current. The recovery interval of 1.5 s was used to completely allow the recovery of fast inactivation making occupancy of the slow inactivated state the sole determinant of the second test pulse amplitude. When neuroblastoma cells were depolarised for 10 seconds the peak available current was reduced to 0.73±0.01 that of the preconditioning test pulse. Lacosamide enhanced the entry of sodium channels into the slow inactivated state in a concentration dependent manner (% of channels in the slow inactivated state: VEH: 27%. LCM 32 μM: 37%, LCM 100 μM: 50%, LCM 320 μM: 62%). Lacosamide (100 μM) more than doubled the reduction of sodium channel availability that resulted from entry into the slow inactivated state.

[0282] The time constant for the physiological entry into slow inactivation was 12.0 s. In the presence of the drug, channels entered the slow inactivated state faster (i.e. time constant for entry 4.8 s).

[0283] As with its more rapid counterpart, the extent that sodium channels undergo the process of slow inactivation at steady state is dependent upon membrane potential.

[0284] Voltage dependence of slow inactivation in N1E-115 cells was evaluated and revealed physiological slow inactivation at potentials more depolarised than -80 mV. However slow inactivation was only 30% complete at the maximum conditioning pulse of -10 mV. Lacosamide shifted the slow inactivation voltage curves to more hyperpolarized membrane potentials in a concentration dependent manner. The first significant change in channel availability in the presence of 100 μM LCM was noted at a conditioning potential of -80 mV; more hyperpolarized than the typical resting potential of many neurons. LCM application significantly increased the maximal fraction of current made unavailable by depolarisation across the range of potentials between -80 mV and -10 mV (-10 mV, CONTROL 0.70±0.02, LCM 0.41±0.04). Lacosamide (32 μM and 100 μM) produced a shift of the V₅₀ for slow inactivation to more negative potentials (FIG. 1B), i.e. lacosamide shifts the slow inactivation voltage curve for sodium channels to more hyperpolarized potentials. Thus, at the given steady-state potential, the amount of sodium channels which are available for activation is reduced by lacosamide.

[0285] The following effects of lacosamide upon sodium channels were identified in rat cortical neurons, NIE-115 cells and Xenopus oocytes:

[0286] Lacosamide did not modulate synaptic transmission under normal physiologic conditions.

[0287] Lacosamide indiscriminately attenuates the rate of synaptic traffic in cultured neurons in a stereoselective and concentration dependent manner.

[0288] The frequency of miniature excitatory post-synaptic potentials is not reduced by lacosamide.

[0289] Lacosamide produced no effect upon resting conductances.

[0290] Lacosamide did not block sustained repetitive firing.

[0291] Lacosamide inhibits slow prolonged bursting in cortical neurons.

[0292] Lacosamide inhibits prolonged sustained repetitive firing on action potentials.

[0293] Lacosamide does not shift steady state fast inactivation voltage curves.

[0294] Lacosamide does not change the rate of sodium channel fast inactivation.

[0295] The rate of recovery of sodium channels from the unavailable slowly inactivated state is not changed.

[0296] In summary, these experiments demonstrate that lacosamide selectively enhances slow inactivation of voltage-gated sodium channels while leaving fast inactivation normal. This constitutes a novel mechanism of action which can efficiently normalize excessive sodium channel function as e.g. seen in mutated channels.

[0297] In particular, by its effect on slow inactivation of sodium channels, lacosamide is suitable for the prevention, alleviation or/and treatment of diseases associated with hyperexcitability. Further, by its effect on slow inactivation of sodium channels, lacosamide is suitable for the prevention, alleviation or/and treatment of diseases associated with dysfunction of an ion channel.

Example 2

Lacosamide in an Animal Model for Stress-Induced Anxiety

[0298] In this study the effects of lacosamide in an animal model for stress-related anxiety were tested. In this animal model, stress is induced by the measurement of rectal temperature. The stress-induced hyperthermia (SIH) test is based upon the principle that mice have a natural hyperthermic response to stress, which reflects the level of stress-induced anxiety. The effects of lacosamide in this model were compared to that of the reference compound chlordiazepoxide (CDP) which is used clinically as first-line anxiolytic treatment. In addition, the novel anticonvulsant drug pregabalin which is also developed for generalized anxiety disorder was used as additional reference compound.

Materials and Methods

[0299] Adult male 129SVEV mice (8 weeks old) from Taconic Laboratories (Germantown, N.Y.) were used in this study. The mice were housed in standard polycarbonate cages with filter tops. Four animals were housed per cage and food and water were provided ad libitum for the duration of the study except noted otherwise. Prior to initiation of the study, the animals were examined to assure adequate health and suitability; the animals also received two days of handling prior to test to minimize non-specific stress associated with the test. Mice were maintained on a 12/12 light/dark cycle with the light on at 6:00 a.m. The room temperature was maintained between 20 and 23° C. with a relative humidity maintained between 30% and 70%.

[0300] Chlordiazepoxide (CDP 10 mg/kg; batch number 94H1023, Sigma) was dissolved in sterile water. Lacosamide (batch number WE11837 (537.1008,SIFA)) and pregabalin (batch number HS3730) were dissolved in saline. All drugs were administered i.p. 60 min prior to testing.

[0301] The test involves two measures of rectal temperature repeated in the same animal with a 10-minute interval. On the day prior to testing, the mice were brought to the experimental room one hour before scheduled lights out and singly housed overnight with food and water ad libitum. On the morning of the experiment, animals were first injected with either saline, CDP (10 mg/kg) or with lacosamide (3, 10 or 30 mg/kg). One hour following injection, each animal was removed from the holding cage and held in a supine position and his rectal temperature was measured by slowly inserting a rectal probe into the animal's rectum at a length of approximately 0.5 cm. The rectal probe is attached to a PhysiTemp digital thermometer (Fisher Scientific) which provides temperature readings at 0.1° C. accuracy. The probe remained inside the animal for approximately 5 seconds or until body temperature reached stability. This temperature was recorded as the baseline rectal temperature (T1). The animal was immediately placed back to the holding cage and after a 10-min interval the 2nd rectal temperature (T2) was taken using the same procedure as in measuring T1. Upon completion of the two rectal temperature measures, the animal was returned to the home cage and then later returned to the colony room. Before each insertion, the rectal probe was cleaned with an alcohol pad and lubricated with sterile K-Y jelly. All SIH studies were conducted between 8:00-11:00 a.m.

[0302] All data was analyzed using one way analysis variance (ANOVA) followed by Fisher PLSD post hoc analysis. Outliers above and below 2 standard deviations from the mean were taken out from the final analysis.

Results

[0303] One way ANOVA found a significant treatment effect. Fisher PLSD post hoc analysis revealed that the reference compound CDP (10 mg/kg) significantly decreased the temperature of the mice compared to the saline-treated mice (FIG. 2). Similarly, at doses of 3 and 10 mg/kg, lacosamide significantly attenuated SIH compared to saline (Figure below). No significant effects of either pregabalin or lacosamide (30 mg/kg) were found on SIH.

Conclusion

[0304] Lacosamide is effective in this animal model for stress-induced anxiety. Thus, the compounds of the present invention, in particular lacosamide, are suitable for the prevention, alleviation, or/and treatment of a disease associated with hyperexcitability, such as anxiety or/and stress.

Example 3

[0305] The focus of the present study was the analysis of potential neuroprotective effects of lacosamide in rat hippocampal slice cultures after glutamate (Glut) exposure as a model for a excitotoxic injury. Lacosamide was administered 2 h before insult and present until the end of the experiment at 24 h after insult. Quantitative analysis of necrotic cell death was performed by propidium iodide (PI) uptake (neuronal cell death in area CA1-CA3) and lactate dehydrogenase (LDH) release (cell death in whole slice). Lacosamide showed a protective effect against necrotic cell death after Glut. Due to the neuroprotective effects found in this study, lacosamide is predicted to be effective for treatment of disorders associated with excitotoxic insults.

Experimental Methods

Model System: Organotypic Hippocampal Slice Cultures (OHC).

[0306] Organotypic slice cultures and among them, hippocampal slice cultures represent in vitro models that keep the different cell types and retain the complex three-dimensional organization of the nervous tissue. Since OHC combine the accessibility/speed of an in vitro system and the retained 3-D structure of the respective tissue found in vivo they represent an excellent model system for the quick evaluation of the effect of compounds on cell proliferation/differentiation in the CNS. OHC greatly reduce the number of experimental animals and time needed. Furthermore they are perfectly suited for detecting metabolism-related effects, pharmaco-toxical mechanisms and even for assessing effects on overall function.

Injury Model

[0307] 7-8-week OHC interphase cultures were prepared according to Stoppini et al. (1991, J Neurosci Methods, 37(2):173-82). OHC (400 μM slice thickness) were obtained from young animals (rats; postnatal day 7-9); for the first 2 days the cultures were maintained in medium supplemented with 25% horse serum to facilitate recovery. After that serum-free (Neurobasal) medium was used throughout the experiment. Serum free cultures are better suited for the analysis of exogenously applied factors since unwanted effects of serum components are excluded. On d11 cultures were incubated with 2.5 μM PI for 12 h followed by pre-selection to make sure only high quality slices (no PI uptake, no anatomical damage) were used in the experiments. After 12d OHC were treated with lacosamide (1, 10, and 100 μM), a vehicle control (DMSO) and a reference substance 2 hrs before the insult. 24 h after onset of insult the cultures were analyzed. OHCs were continuously exposed to lacosamide from 2 h before until 24 h after the neurological insult. Thus lacosamide was present during all stages of the test.

[0308] Glutamate induces excitotoxic (necrotic and apoptotic) cell death by acting on all glutamate receptor subtypes: kainate, NMDA and AMPA receptors. OHC were treated with lacosamide or either one of the two neuroprotective reference substances--the NMDA antagonist MK-801 (10 μM) or the Na-channel blocker TTX (1 μM). Two hours afterwards, OHC were subjected to excitotoxic insult by administration of 15 mM glutamate for 24 h.

Quantitative Assessment of Damage

[0309] PI-Uptake (Necrosis)--Assessment of Neuronal Damage.

[0310] 22 h after the respective insult, cultures were stained with propidium iodide (PI) for 2 hrs (PI uptake/incorporation serves as a marker for cell degeneration). Fluorescent images were acquired semi-automatized (Nikon motorized stage; LUCIA software) and analysed by densitometry to quantify necrotic cell death (LUCIA Image analysis software). Damage was analysed only in the CA area (CA1-CA2-CA3) thus representing neuronal damage. PI staining proved to be not suitable for reliable cell death analysis in the AD. In order to combine data from individual experiments the densitometric mean value of the respective insult of an individual experiment was set to 100% damage. All other data are given in % of insult damage.

[0311] LDH Release (Necrosis)--Assessment of General Cell Death.

[0312] Medium samples for this analysis were obtained from the same cultures used for PI-uptake studies. 24 h after insult aliquots from cell culture medium (1 well is shared by 2-3 slices) were collected, frozen and kept at 4° C. Subsequent sample analysis of LDH activity was performed using the CytoTox96® (Promega Corp) colorimetric cytotoxicity assay. Measurements were performed on a Magellan Plate reader (492 nm vs. 620 nm). This assay detects LDH release from all damaged cells thus representing an assessment of general cell death in the slice culture. In order to combine data from individual experiments the mean value of the respective insult of an individual experiment was set to 100% damage. All other data are given in % of insult damage.

[0313] Experimental Setup and Area of Analysis.

[0314] On d12 in vitro only high quality slices were selected and treated with lacosamide (1, 10 and 100 μM) 2 h before insult onset. lacosamide was present from 2 h before until 24 h after insult onset. 24 h after the insult the assay was terminated and cultures used for analysis: 1) Culture medium samples were obtained for LDH release measurement. 2) PI uptake was analysed in the cultures. Neuronal damage was assessed by densitometric quantification of PI uptake in area CA1 and CA3. In all figures error bars indicate standard deviation. Data were analysed by one-way ANOVA followed by Tukey all pairwise multiple comparison post-hoc test. Statistical significance is defined as *p<0.05, **p<0.01, or ***p<0.001.

Results

[0315] Effects of Lacosamide after Glutamate (Glut) Insult

[0316] Neuronal Damage.

[0317] As assessed by densitometric PI uptake analysis lacosamide had a statistically significant effect on neuronal damage in all CA subfields (combined CA1, CA2, CA3) 24 h after Glut (FIG. 3). This was true for all three concentrations of lacosamide tested (p<0.01 S1 vs. Glut; p<0.001 S2 and S3 vs. Glut). The reference substance MK-801 (10 μM) provided significant protection against Glut-induced neuronal damage (p<0.001 for MK-801 vs. Glut). The second reference substance Tetrodotoxin (1 μM TTX) showed also a neuroprotective effect after Glut (p<0.01; TTX vs. Glut). The extent of lacosamide mediated neuroprotection was similar to that of TTX but smaller than that of MK-801.

[0318] Overall Damage.

[0319] As assessed by colorimetric measurement of LDH release, lacosamide had a statistically significant effect on overall damage 24 h after Glut (FIG. 4). This was true for all three concentrations of lacosamide tested (p<0.01 S1 and S3 vs. Glut; p<0.001 S2 vs. Glut). The reference substance MK-801 (10 μM) provided significant protection against Glut-induced cellular damage (p<0.001 for MK-801 vs. Glut). The second reference substance Tetrodotoxin (1 μM TTX) showed also a protective effect after Glut (p<0.01; TTX vs. Glut). The extent of lacosamide mediated cellular protection was similar to that of TTX and MK-801.

DISCUSSION AND CONCLUSIONS

[0320] This study was designed to investigate the potential protective effects of lacosamide after a neurological insult in-vitro. As endpoints two different readouts were used: Specific neuronal necrotic damage in the CA region was quantified by densitometric PI uptake analysis and general cellular necrotic damage was assessed by measurement of LDH release from the whole slice.

[0321] High glutamate levels (Glut) caused massive neuronal necrotic cell death (CA1 more affected than CA3). Administration of the NMDA antagonist MK-801 reduced the neuronal damage by app. 80% and overall damage by app. 50%. This indicates that MK-801 provided protection for neurons but not for glial cells. The Na-channel blocker TTX provided app. 50% of neuronal damage reduction and app. 20-40% of general damage reduction. Lacosamide showed a significant protective effect on neuronal (CA1 and CA3) and general necrotic damage after Glut. Lacosamide significantly reduced Glut-induced necrosis by app. 40-50% and overall damage by app. 30-40%. According to these data lacosamide seems to have an anti-necrotic effect in a model of excitotoxic insult (Glut).

[0322] Thus, the compounds of the present invention, in particular lacosamide, may be suitable for neuroprotective prevention, alleviation or/and treatment in particular in a neurodegenerative disease or/and psychotic disease.

Example 4

[0323] The lacosamide-induced shift of the slow Inactivation voltage curve to more hyperpolarized membrane potentials (see FIG. 1B) and/or the increase the fraction of slow inactivated sodium channels has been observed in different cell systems. FIG. 5A shows this pronounced shift of the voltage curve in Xenopus oocytes expressing the rat type II sodium channel alpha subunit (Na_v1.2) in the presence of 100 μM lacosamide. In rat dorsal root ganglia 100 μM lacosamide markedly increased the slow inactivation of TTX-resistant sodium currents (FIG. 5B). Although lacosamide (100 μM) significantly increased the fraction of sodium channels slowly inactivated by a 10 s depolarizing pulse the half-life for channel recovery (i) was not significantly changed (FIG. 5C).

Sequence CWU 1

1

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cttcttgggt tcagcatgga gtttgtaaaa ttcatccatg cacctgtgtg 900tagctccata ttgtcctttc ttattgctgc ataaaattcc atgttctaca gtgtatttat 960ccattacggt attttggaaa tttccaactt ttagcaagta tgaatagtgc tgcacattct 1020agggcatata tcctcatttc tcctgggtgt atacccagga gtgacattgt tgggtcatag 1080gatactcaaa tggccatgtt aatagaaatg accaaaaagt ttttcttttt atgtgtttgt 1140tgtcgttgtt tgttttttga gacttgactg tctcccacac tggagtgcat gatcttggct 1200cattgcagcc tcaaactcct gggctcacac aatcctccca ctttggcctc cccagtagct 1260gggactatag gcatgcacca ccatgctcaa ctaatttatt tatttcctga ccttttcttt 1320tcttttttct tttctttctt tctctttctt ttctttctct ctttcttctc ttttctttct 1380ctctttcttt ccctcccccc tccctccctc cctccctccc tcccttcctt ccttccttcc 1440ttttgtagag gcagggtctc actatgttgc ccaggctgct cttgaactcc tgggctcaag 1500cagtcctcct gcctctgccc accaaaatac taggattaca gatgtgagcc actgcaccca 1560gccaacggtt ttccaaagtg gttgtaccaa attcccctct gtccaacaga atacaagagt 1620cagaaatggg ttcagatcca cgttagtgac cttgggaaag tttttaagtc tccctcaccc 1680tcagtgtttg catctgttcc acggggctgc tgtgaagact cagtgggaga tttaccctgg 1740caggagctcc atcagtgaga tgtcactctt tcctgaaaaa ctctggggtc ttcacagatc 1800tatgcaggta atgctcctgc tctaaaactg aataatcttc tcagagaggt ccatcagaac 1860aaatgataag ttcaactcag ctcctctcat atgactggtt cttcccatct gaacacatgg 1920gctcgcttct tgtttcatat tagttgctgt tcacctttta tatctgaaac aatgtcaagt 1980acaaaaatca ctgatatttg gtgagcgcct taaaagcccc tccttctccc tgaatcccac 2040acaattctat ctccttgcaa ttccaatcac tcttggttta atcatttcat ccatatcgtg 2100acaagttaga aaatcttgaa agtgctatgg ggcaatgtat aatagttggt gcattggcac 2160agaacgggga ctttatataa agacatatca tctttccaga gtgttccaaa agaactcgaa 2220tattgatatg tgtgtgtggg gtggcgaggg gggaagggaa ttaactagga tttaactagc 2280taaggcttga aagaatattt gcctttttca tccttttccc attcctctcc atttggcctt 2340tctgcgtata caagctccat gaaaattcaa tggtttcttg gtacattgaa tttgcaagac 2400agtttgatga catcttataa gcttgaagat atgaatacct tgtggaccca gacattccac 2460acctaaggct attcctagag acatgcattc ttatctgcac caaaggtacc tgaggcagta 2520atgtttaata gccccaactg gaaaaaaaac agatacccat caacaagatg atggataaac 2580aaattgtggc atattctctt gatgaaatac tatacagcag tgaaagtgaa tgaatcacag 2640ccatgtgtga caacaaacag gtgaattttt ctaaaattcg aaacagatta ggatgtatga 2700atcttgtttt ttttgtttgt ttgtttttgt tttgttttgt tttgtttgac agagtctcac 2760tttgttgccc aggctggagg gcagtggttt gatcttggct cactgcaaca tcctggactc 2820aagggatctt cccatctcag cctcctaagt agctgggact aggttcacat caccatgcct 2880ggttaatttt tattttaaaa aaggtttttg gagagacagg gtcttgctat attgcccagg 2940cttgtctcaa acccctggcc tcaagcaatc ctcatgctct gcctcccaaa gtgctgggat 3000tacaggcgca gacaccgtgc cctgccagat gaatcttaaa gacataatgt tgaaccgaag 3060aaacaagaaa ctgtagaata tatactatat gattattcca tttatataaa agcccaaaag 3120aagcaaagta aaattgtatt ggttaggaac gcataataag gtagtcaaac tttttttaaa 3180aaagcaagat atgaatacca taaagtcagg tagcgattat tgctggaata aggggctgtg 3240taagcgtgtt ggcaaagggg gttctgcaga ggtggtgatg ttccatttct agccctagac 3300ttgatttcat gagtgttcat ttcagaccaa tttcttaact ccgtaccttt atgttttatg 3360catttttctt tgtgcttatt gaatttcacc acacaaaaag cagaatggga agtaatcaaa 3420gtggttctgg agagacgtga gtatcaagca aactatacca cccagaaccc ctatccagcc 3480aactaggacc tggttaatta tttcctcctg ggagttcaga cttgtcacct ctggggtctc 3540caaggtagaa taaaccttta attccaactt gcaggagtcc ttgtgatttg aaacgttcac 3600agaagtaacc ccaaaccact ctctccactt tcaaaaatgg tcttttgcta aacagagcaa 3660atttgtttag agactgacga atcgcacctc tagacacaaa tccccttctc ttttctgtct 3720tttaagtttt tttcctgcct ccatcctgcc ttctccttgc aagatgctgg ggagcgtccg 3780gctgtctgca accgaaatgg aacggggtgg aaaacaggct ttcctcccag gggaggagga 3840agcaccccaa ttcccccctc cctgcctccc aaccatgcga cgctcccctc tctcccccac 3900aaactccgct gagcccggta cccccgcgcc tccacgagcc tccacgattg gtcgcgggcc 3960ctcatgtgtc gacactctgg gtgggtcctt ctactgttaa actcatcaat tgctcccctt 4020ttccgtttgc tggccagtgg ttcagacctt tgcgcccatt tttttttcct ctttaccttc 4080ttctacccgc aaccctccac accagtctta ttttagcaaa acctagagaa ggaggaggtg 4140gagggatttg gagggtggag aggcattgcc gcatccaggg gcagctattg agtggctaag 4200cggagggcgc atacctctct ctctctctct tttccccctg ttgggaattt tcaggatttc 4260actgctgcaa tttaacccca agatgaggca ccattgagcg aaacgctgtg cgcacataca 4320cactcacact tcctccggga gcagaagagg cagccgttgg tgattcagga agaaaaaaaa 4380tttttttttt tttttttaaa cctggaccct gcggtgtgaa gactccttag gaaccctctg 4440gagcgtctta ctccccttcc ctcctctttc ccttcccttt catcttcttt gtttttattt 4500tattttattt ttggagctac agatctttca gcatttttaa ggtctaggaa ctccagcaaa 4560acagaagggc acttaatttt tttttttttt ttttttgccc tccccaccca gacctgggtt 4620tcgtctttct ttatttttaa atatatatat atttttttat tttttatttt ttattttttt 4680ttaatgggcc gagcgcactc cttttgcaag atgccagcct gacccggacc tcggaggaat 4740ttgaagcttc cactgcgtcc cggggggggc gtcctttgca aaccgttcgc gtcttaaagg 4800gggtgtgcgt tgggtggatt tttttttttt aactgtctct tttttttttt ttccggagtg 4860ggtggactgg ggattgcctg gattccttcc tcggttattt tttgcctcgc ttctctctcc 4920cctcccccct cctccccggg cccccgcgcc ccgcccccgc accctcctcc cgcccctcct 4980tctccggggt cagccaggaa gatgtcccga gctgctatcc ccggctcggc ccgggcagcc 5040gccttctgag cccccgaccc gaggcgccga gccgccgccg cccgatgggc tgggccgtgg 5100agcgtctccg cagtcgtagc tccagccgcc gcgctcccag ccccggcagc ctcagcatca 5160gcggcggcgg cggcggcggc ggcgtcttcc gcatcgttcg ccgcagcgta acccggagcc 5220ctttgctctt tgcagaatgg cccgcttcgg agacgagatg ccggcccgct acgggggagg 5280aggctccggg gcagccgccg gggtggtcgt gggcagcgga ggcgggcgag gagccggggg 5340cagccggcag ggcgggcagc ccggggcgca aaggatgtac aagcagtcaa tggcgcagag 5400agcgcggacc atggcactct acaaccccat ccccgtccga cagaactgcc tcacggttaa 5460ccggtctctc ttcctcttca gcgaagacaa cgtggtgaga aaatacgcca aaaagatcac 5520cgaatggcca tatccttttg cccgaacccc agcagcagct gcgcctcccc ctcctccctc 5580cgcctcccct cttccaggct gggagagaga cccgggggtt gatgggaggt ggggaggagg 5640ggggtcttcc aggggctggg agagggggca ccgggaggag tgtgaaagaa tctctccacc 5700ccgagctggg ttgagctacc ctggaggctt gggaatgggt ttgtgggggg ctggggggtg 5760ggcagcggag agtggatcct tcccaaggac cgactctaga atgagatctg gggcctgggg 5820tcgtgcagga gccttggtgg gggctttcga gccaagtccg gagggtttgg agttctacgg 5880agtgagcttg gagcgggctc gggcctgggc gcttctggcc agggcagggg aactatgggg 5940gccttggttg ggttttcttg gccgtcgctc actggagtcc acgcagggga agctggacag 6000cctctccact actgctttcc ccaaggtggg gggccgccgc acttttaggg cagggcgctt 6060gggggctccc agggctaaga gcaagaggga gtccatgtgg ccttcacact gagaagccag 6120cactggccga agtgagtacc ccagggtggg ccgctgttcc tatctggaga ggatagtgat 6180gggctggggg gcgcttatgt ttccctcatg tgtgcaggtc ccattgcctt taaccgctga 6240ttggggaacc tcatcatctt tgggggtgtc gagaaagaga tcccacttgc tttatctggg 6300cccctggcct gggaagacct gatctggaca ctttcagtaa gaaagacagg gcaacagcaa 6360atgaggtggt gggtccattt tagagcacca tgtccagctt ttcctacccc gagtagccga 6420gagggaacac caggagaatc agcacccatg tggacatctt aggtaggtaa atgcctttta 6480aatttttttt tttttaatca aagatccaga ggaaaaaggt gaagcccaca ttttcttctg 6540tggagatgct atcaaaatgc agatcttctg tgtttcttta aatccctgcc tgcttgaaat 6600aaaccttgag gagggcttaa catctatcga gatgtaggca ggcaagggtg ggtaattagt 6660cgggctttct agcagttatc taagcatgac ccagattcca ggagggggga cacaccctgc 6720tgcccaggct ggctggccac tgtgccatgc ccagatgtgc cgcttctccg cacagttcca 6780accagctgcc ctctgtgtaa aaatgaacgg gctggatggg tccctggggc tcagcgatga 6840gtcccctatc ccttttgtat gtggttttgc agttatagac taaacggggc tgggccctgt 6900gtggtctccg ggggttgctg tttgaggagc atggcgggtg gtagagggac tcacttcagg 6960ggggttcaaa atcgagcctg gcgcttggat cctgggtgct gggattgcaa cagagggcac 7020tgaggttttg gagtgtgtga gtggtctact ttgagggtgg ggaaaattaa gaagttcagc 7080agaggtgctt ttgaggggag catacctcta actacgatgc catctccgtt ggtgcccaaa 7140gcaggtgcca ggtctttgct tcctaagttt cagactctta aagaggctgg ttcttaaggt 7200tagcaattcc tcaccatccc aggcccattg aagtgctcag gggtggcttg attactctgc 7260ctatcaacag agtgaggagt gggagtgcct tgcaggagga cagggtattc atgggtgcac 7320acccagttag ctccaggagt gagagggctt tgctcggctg acaggtttcc tcattgaaaa 7380tggctttaga tcgccttctg gagcctggat ttggagactt ctaagaggaa aggaaggagg 7440tggggagccc ttctgctgtg tccttagctt acctctgtcc agcctgaatc ctgcagattg 7500gagggctgtt gggggagagg gggattgcag tggcccctcg gaagggggaa tcgtgggaga 7560gggaggcagg tgaattgcga gtgttgcttg ccacttcatc tattctctgg ccagctcgcc 7620cggggctttc ttgctcttat gatgagtttg tgcattatgc tctctgcaga ctgtttttgt 7680tctctttgac ccgaggtaac aaacacatta tacagcccta ctctggaagg gaaaactccc 7740cacctcacaa tctgtcatcg agctgggtca tccaggactg agctttctct gtcctggatg 7800gagcggaggg cggtggcggg gtgggtggga gggttggaga tgagagggga tggacagaga 7860cctggggagg gaggtagtga ataaaagaat tcaggccagt gtaaagagaa agacacgtgg 7920aatgtcagag tcacgatacc agggcagaac attctacttt ttaatctaaa tatttctgcc 7980attaaaaaaa aatgtttcag catatcctga gagtgaaaaa aaaagtgtgt aggtacttaa 8040ataaagtcta atatatgtac aggcaagtac atatattcag atgcatagat ttttacaaaa 8100tgaacacacc cacgtatcca gcacccaggt cccgatcagt gccctggaag tccccctccc 8160cataccgcct cctagttgct cccccaacaa gggtaccgct cacctgactt ctaaggttca 8220ttttgcctct tttaaacatg taaatggagt cacacagtac gttcttttgc cactggcttc 8280ttttgctcac atctgtgtat gtgactctac tacaatctat ccattctact gttgatgggc 8340atttgtgtca tttctgtttg tgccactggg aacattcttg tgtcttctat tatttttttc 8400ccacagttct cttagatagg agtggaatcg cccctgctac tttttgatgc atgtgttgtg 8460ggatgtgtat ttggaaatgg tgttgactaa gggttgcagg tcgatatgga aagcaggttc 8520ctccctgtct tgtttaagag aagtgagtga atgatccatg aacttgtcgg tatgctcaca 8580gggcctaaga gtgctacttc caaatgtaaa ttctggcatg gtacactggt gaaggatgca 8640gtcttgcttt ctccacactc ggggcaattt gtcactatga tttcttcctc tttcatccct 8700cagtgggtca aacttgaagc catcaatgac aattaagaat cctcatttat ttcatttttt 8760cccctcttcc taagtgagga aacccaaatg gaagtctttg atgttcaaat ttacattgcc 8820gtgtttttct catgccaggc agcaagccgt cttgaccaca caccttggtt tcatgttttc 8880attgactgga attgtgattc aaatagggcc atgagggtct ctgatgattg ccgaagagct 8940cagatctgtc agctcaaaaa ggagcatctg tcagccttcc tagagttccc tccccactta 9000atgccactca ctccttctac caagtgccaa ggtgaatgtc atctttccag ccctccctgt 9060gccaccaggt ctcccactga acatgatgta gaaactcagg ccatcggagg aacactggaa 9120gcaggtcagt gtattatcac gcacagttgc ctgaattaca cgtagaattc cagcttttca 9180tccggtttgc agaaatctta acaagacacc taaagtcaca ttgacatcag gtgacatcac 9240tttgacatct gtggacattg gctgattggc actcctctca tttttttttt tttttttttt 9300tttaagaaaa gctctctaaa gagaaacttt ctgcatgaga agcgctggga gacatgggag 9360caggttatca gactcttggc ctgtcctgag agatagaatg ttctagaagg tactgccgta 9420gagggcagga tggtgtcact tacgtgatcc ttgtactaga ccggcttggc tggtatttcc 9480agaggagcaa aattctgcga agtaaaattt agcacggctt ttccaatggg agtattttca 9540aaaagggtgc aatttcttat ccacaattcc ccaatccaaa aagctccaaa aaccaaaaga 9600cgagctcata tagaggtaaa acctaacctg aactgacttc agtttgaagt cttaatttac 9660agttttcatt cattctactt ggtgtgcatt tgagtatgtt ttgcagcaga aatgttagat 9720gtgcttgatg atgaggtgct gcttcagctc ctgactgtta ggtctgcatt gtagtcctgt 9780caaactttca ggtgtatgga agttgtcttg ttaacaggat ggttctggtc cagcaggatt 9840tgggtggggt ctgggattct gcttttctag ctagcttcta gggattcccc atgtggtaag 9900ttcatgggct agggttggag tatccaggtt agatcataga gacatcttgt tatcattttt 9960cttttcctta aaaatcaggt ttataggggc cgggtctggt ggttcacgcc tataatccca 10020gcactttggg aggctgaggc cggtggatca tgaggtcagg agttcgagac cagcctggcc 10080aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccaggcgt ggtattgtgc 10140gtctataatc ccagctactc gggaggctgg caggagaatc atttgaacct gggaggcaga 10200ggttgcagtg agccgagatt gcaccactgt actttttttt gagactctgt ctcaaaaaaa 10260aaatagattt attgatgtat aatttatttg tagcaaaatt cacccttttg acatactggt 10320ctgcaagctt tgacaaatgg atgtagttgt ggccaccacc caaatcaaga tatgggacag 10380tttcatcaac cctaaaatac ccccacagtg cccctcttga gtcagcaccc cacttctcca 10440gccccttcaa ccactgatct gttctccatc cctacagctt tgccttttgc cgaaggtcat 10500ataaatgtaa tttcacagta tatagccttt tgaatgtgga ttcttttact cagactttga 10560gattcattca tgctgttgcc tgtgacagta gcgccttcct ttttggtgtt gagcaggatt 10620ccatgatatg gatggaccag agtttgcttc ccagccgaag gacattggga tgcttccagt 10680ttcaatgatt atgaatagag ctgctataaa cattggctta tgggttttag tgggaacatt 10740tcatttcata catttcattt ctcttgggta aattaaccca ggagtgagat tgctgagttg 10800tgtggtaggt gtatgtttaa ttttataaga ggctctcaaa ctgttttcct aagtggttgt 10860accattttac attcccatct ttgcaatgcg tctaaaagcc ctgagttctg aattccaaag 10920cacgtctggc ctcgatggct taggattaag gatgtggatc tatggaaagg agtggaagta 10980atagtgttaa atcccggtca gagaaataag aaagattaag gatgtcattc aaagctatgt 11040gcctgcacta gagagagaga aagaaggggt tctcttgggt ggggttccac ccctccctgg 11100tagttctacc attccccagg aaaaagtcaa gctctgaggc tgtgagaccc atgatcttta 11160ccctgttctt caccactgca accccagtgt gtgggacaaa gcaggcgtcc tataaacgtt 11220tgctgagcaa atgagaaaag gtacctgtct tcacccatta actaaattgt ataacatcta 11280tctgatctac ccttgtgcca acgttttagg attttgatgg gttttagttg cagggggttg 11340agagactgtc catgagatta tcagaccaat gaaagtttct gaaatgttag tgcttgagta 11400gattggatgc agcggcccct tgagaatgaa gtctttcttc agggacttgg agtgggaggc 11460atctgttggg tgcgtagggc ttatgcttcc ccctccctgt ttccccccca gtagcaagca 11520cacatataca ctttctcagc aataaaaagc accgccggga aggtggactc catccagaaa 11580tgatcagagc ctaagagccg tgcagtaacg catttccgag aatgccagct cagctcctga 11640gaaaagggcc ggatgggatg gtgcctgctc tgaaagaggg cagagaggag agggaaaaca 11700ctccggactc tgggtcagac tggcccaggt tcacattatt caccagccat gttatcttgg 11760gcaccagagc ctatttcttg acatgcatga tgaggatatt ccttctagta gcatctccct 11820tggagggctc tcaggagatt aaatggggtc gtgcgtgaaa aatggccagc acagtctcca 11880gcacagagaa aaaccccaaa acgccagagc cgtaatacta tggagtcatt taggttccag 11940tgttcttttt ttggaaaccg gccagaaaag aggctttctg ggtgggaatg ggagcgaagt 12000gccccccccc accaccccct gcgactggtc agtgtggatt gattaacctg atcgtggcgc 12060tctttaaagc cacctttgga cattttgcat tctccgttct ctctggaagc tttcagggga 12120aaaaaaattc gtggccactt gacccatttt tctattccct tgagtctaag gtaaaaatta 12180attctctttc ctcctttggt ccctccctct ctctgtgggt gacaaggtga gggagtttta 12240aagtatataa ttagcttccc tcttcccctt ttgcactccc tgtctcttcc tttggggccg 12300gtcgagagtg cagcccagga tggccacccc aggtgtccac tgcaaactcc acagaaaaac 12360tttgctcaac ttttggttta gaatttaggt acccccctcc ccttccaaac tttggtcttc 12420tttctcctca ctccctaaaa aaataggaaa aacaaggaac attcctggcg agggaaccat 12480gagtgggcac agcaacttag gtttcaaaaa ccactgggcc tcagttctta tctgagtagg 12540gtgacccttc agccagggtt gcctgggact atcctgggtt tagcatctct ggaaactcac 12600agtcctgggc aaactgggac gctggtcacc ctaatggtga gttcttaaca cctgagagag 12660aagaatggtg caagagatgg tgccgttgac caagaaaggg ggagagtcag ttacttattc 12720cctctgaaaa gccaagactt tttattggaa tgaatgcagc ttttagaagc cgtctttaag 12780gcagctaata caagagagat tccagctatg aagggaaatg cctgagttaa gtccggatca 12840agttttgaca tctcgcttcg gtcagacacg gctttatctg ccgttcagac tgggagcagc 12900cgtgagtctt ccttaaaggt gcctgttgct caggcggcac ctgcagttag aaattagcag 12960cctcccaccc ccagccccca aataacagga ttcaagagtc ccctctctga agccatgagg 13020gaaacccaac ttagtcaccc acttgccagt aaataatatt catgctgtta agttctgttc 13080tcattttagg cctatgtgta aaaaatatat gtaattttaa actgattttt aaagtatttt 13140catacgaaca gcatttgcag gagggcgaag tctggatgtt acctttttgt aaaagtggat 13200ggatttgtct tcaatgagac tctggggcag acttaaaact tggcccgcag tggtgttaca 13260tggattctga tcttccagag tctgtcacgt tcttttatct ccatgatctt tattatcttc 13320tttattgaga atgatgggca tggtgtgtgt gggtgggagg gctatgctga ccatcactgc 13380agtgaaatgt gttcgtggca tgttgtggcg tctgcatagg aatgtgtctg tttgattaac 13440agcacaagca gtggaggctg taaggaggaa aagaggaggg aaggtgatat tggatggagg 13500ggagacatat agagcttggg aacagtccac cctggctgca aatctcagct ccagctcaca 13560gttgtggagc ctcagtcttc tcctctgtaa aacggggaca gtagtcctat gtccgaggaa 13620ttgtaagaag gttaaaagat actgtaccca gaaagcacat ggcatatata atcatcctgt 13680gaagtagcca actcaatgaa ttttatttta tttattttga gtcagagtct cactctgtca 13740cccaggctgg agtgcagtgg catgatcatg gctcactata gcctcgacct cctaggctca 13800agcgatcctc ctgccttagc ctcccgagaa gctgggacta taggcatgca ccaccgtacc 13860cagctttaac aacataaatt tatatatata tatatatata tatatatata tatatatata 13920tatatatata tatatatatt tttttttttt tttttttttt tttttttttt ttgagatgga 13980gtttcattct tgttgcccag gctggagtgc aatggcgcga tctcggctca ctgcaacctc 14040cgcctcccgg gttcaagcag gacgatgggc atttgggatg tttctagttt ggggtggggg 14100attgtttgtt tgtttgctgt tatgaacaat gctgctgtaa ggaatcaata attttgaatg 14160aatgaattcg aggtgttaat tttagtctgt gtacttggaa atctagcttc acctagaatc 14220agctgagatt catcagcatt tatggcagga gctaagacat ttcacagctt actcatcatt 14280ttctctaaga ggctgggtca accggttagc tcttggtcct gcttgtattc tgagagtcag 14340aacctgtggt ttagacactg gcaattgata tggttgtaga gaagcagcat ggttgagttg 14400agagcatgga ttctggagct aggtggctgg ggttcaaatc ccagctctac tagtcactgg 14460ctgcgtgatc ttgggcaagt cacttaagtg ttctgtgctt cagtttccca gtctgtccca 14520gtggtgattc taatagctcc atggggatcc taatagctcc tatctgggag gattaaatga 14580gttaatacat ctgatgttta gagtggtgcc tgacacttag gaagcactat atgtgtttat 14640acatggaaga gtggatagat ggatggactt atgtgggtgg ccatatttgg gcttctctga 14700tccactgctg agaatagtgt gtggcacaca gtaggtgctg cataagtgtt aatattctgc 14760tctttcttgc caagtctctc aactcccttg atctctgtta tttttggcgt ctgtgttgtt 14820aacccattct tctgaatgat cagctgaatc actgttgctc caatatataa gccaaggaga 14880acacaatcac aaggtctcat tgattgtcca tactagaatt ccatgattcc taggcccaag 14940taggattttc cccacgtctc agcaatcctt cttccatgtt tctaatcttt ttctctcatt 15000tgttatgccc cattgccaga ctctccaatc tccccacagc

ttccccttcc tctaactata 15060ctgtctctag tcttaccttc tccctaaggg caccgtcttt gaagacatca aatacttcag 15120agcaccaaat ataggttagc ttctctgagg gccttacaag gacatggagt gtttgggtct 15180tacacaaatt ggaatggtca gaaatgttta gagacttgag ttgtctttga aagagttgtc 15240agaatgcaaa tttttgactt gtggcctgtt tctgatcaca acgcagtctt ttaagttatg 15300gatcatagct ggatgtttgt ggtttagagg ggatggaggc atcctctgca gttagtgttg 15360gatgtctggg tggatggatg gatggatgga tggatggatg gatggatgga tggatggttg 15420aacagatgca tggatgagtg gatggatgga tggatgggat gaaggaagga aggaaggatg 15480ggtgattgga gggtaggtgg gtggataagt agattggtag atgactcgat gggtgggtgg 15540acaaatggat gggtgaatgg atgactggat ggatgactgg atggattggt gtatgagtga 15600atatatggct ggatgaataa ataggcagat gactagactg gattgagggg taaaaatatg 15660gatgactgga tgggtggatg agtggatgat agatggttga atgggtgggt ggatgggtgg 15720atgttggata taagggtgta tggtagggta gctgtctatg tgtgggtctc cctgatattt 15780ggtgttctgt ttgacttggg aatgaccaag tctctccgct taccacctta tttgtacctt 15840ttccagtatc aagtgaattt tgcacacttt tgtaaaaatc aataagattg tatgtttagg 15900actttgggag gccgaggcag gcagatcaca aggtcaggag atagagacca tcctggctaa 15960cagggtgaag ccccatctct actaaaaata caaaaaatta gccaggcgtg gtggcgggca 16020cctgtagtcc cagctacctg ggaggctgag gcaggagaat ggcatgaacc cgggaggtgg 16080agcttgcagt gagccaagat catgccactg cactccagct tgggcgacag aacgagactc 16140catctcaaaa taaataaata aataaatatt atatgcttag gttttaccta tgtaattaga 16200aagctccttg agggtagggg acagtgattt gccttcctca catcccccca aagttcctgc 16260actatatcat gcataagtat ttaattgagt aatggtgagg aaagtaaaca gtgttattga 16320acaaagatta ttaaaattct ggaaacacct ggttttgttt cagcactggg actgaaagtg 16380gaattccttg gattttgctc cattggtgga taggatagca tgtggtggtg gactggtaga 16440ctctttctct tccaagcaga ttgggtaaat gccccagatt cttacccact agtcagagat 16500tacagattac tgattgatat ggtttttctc tgtgtcccca cccaaatctc atctcaaatt 16560gtaataccca catgtcatgg gagggacctg gtgaaggtga ctggatcatg ggggtgattt 16620cccccatgct gttcttgtga tagtgagttc tcatgagatc tgatggtttt aaacttgtgt 16680gggcctcttt cctctctctc ctctcctgct gccatgtaag acgtgccttg ctttcccttt 16740gccttctgcc atgatttgta agtttcctga ggcgtcccca gccatgcaga actgtgagtc 16800aattgaacct cttttcttta taaattactt ttatagcagt gtgaaaacgg actaacacac 16860tgatgtagca aggtccttta aggccccatg tgatctggtc cctgttttgt ctttgatctc 16920atctctttca ttgtctacct tcctttcatt gtctattctg tctcagccct gctgaccatt 16980ttactcacac ccatgtcatt tgcattacat gacattcctt ctgttcagca taagctattt 17040cctctgcctg catcactgtt tctccaggtc tccccatggc taactccttc tcttcattta 17100ggtctcagcc caaaagttac ctcctccaag aggcctatcc ttttcattta ctgaacatct 17160catgtacaaa aaagaatata aaatatatgt atactctctc atccacaaaa aaatctctga 17220agacatttta atgtatttca tcccatacct ttttatgcat gtaaactttt aggaacacat 17280ttccatgcca ctaggtatcc ttgaaaaaat aagggccacc atgtatagtt gcacaggttg 17340tgcactgcac aaagatagca tgtcacatat cttaagtatc atggagcttg tatgtctact 17400atttcagtac cccagctgat aaaagcttaa gtatcttgtt ctagcaagat gaagctatta 17460tgacaatttt tgacagagaa aggggtgttt tgtttaagtt cacaatcaga gaaatgggtg 17520tcttgtttaa tttcacaacc agagaaaggg gtgtcttgtt taaattcata cagtggtgct 17580gtatgggttg gtggcaaccc cagaaaagac tgttgttaat atctgataat gttccacttt 17640atacgtgtat tatattcatg taacaatctc tggctgtttg ttttgccatt ataaataaca 17700gtgcagtaaa catctttgtg tgtgaatctc tgtccaaggt tctgatagtt ttctgaatga 17760aattcctgtc tatatatggc actccaagcc cataattgaa actctgctgt taccactttc 17820tttgaatctg tagaaggaat tttgagaaca ggtgactggt atattcagga tgttgatgac 17880aaggaacaga gaaagaacag ttaaatggtt tggaattttt cctgggctgc atgtaaagca 17940gtgcttttga actgggagca atttttcccc caaggggact tttggcaatg tctggagacg 18000tttttggttg tcacgaatgt agggggaggg ggcaagatgc tactggcatc tggctggtag 18060aaaccaggga tgcagttcag catcttaaaa tgcacaggac agcctttctc agtaaagaat 18120tatccagctc caaatgtcag taataccaag gttgagaaat cttgatgtaa tcgatgtcat 18180gggtttcttc aagaggagtg ggtggattta gggtttttgg gtgacttaaa tttaatttac 18240agtttgtctt cctagctggg tgtctaagcc agctttctgt gaactttaga tcccacacaa 18300gaagcaacag gcttgctacc gacagattcg ttgatgtaaa tatagatgag tgtatagaag 18360gaaatctcac ccagagctgg aaaatgttgg aatgaaaact gcggcggcct ccccttctct 18420ctccttcccc ttctgttgcc ctgtttgaaa atcgtgcctt actttctttg gtctcctggc 18480atggtgaatg ctgctggtat ggactgtgtt tctatatccc cttgatcccc acacccttag 18540gaacgtacag gagagagacc ctggagcata tcagcttaga gatggagggg aatgggaagg 18600agtgcgttca ttcattcata aatgttgact gagcacctac tgtatgctag gtgaatggga 18660ggacgtgagg gcagggaggt gacaaggttg gcttattctg ggctttgtga actatggtga 18720ggattttgtt tttttccaaa ggaaatggaa taaccactcc ttttttcccc ccgatatacc 18780taaacttttt gattttcata acaaaaatgg gcttcctttt gtatatttgt tttgagacca 18840gccgtttttc caccaacact gatcacactg cagtgagcat cctggtagag aagtctttgc 18900acacttctgt cactgtttcc ctaggacaga ttcctggaaa tggtatggca aggttgtatg 18960tcaggctttt gggccaggtt gcaagaaaca ggaagtctgt gccctttcaa attccaaggt 19020cccctttccc tgacgacgtg gcccaatcag gcttgccctc ccttgatttt acatcttcac 19080caatcagata agtgaaagtg aaatcctgtt gtggtatcct gtgcatttct ttggtgactt 19140aagacataga gcattttcca gatctctgtg ggctgtttgg atatcctttc ctctgttttc 19200tcaggcacat tctttaccga tgtctttgag ggattgagca agtttctgtt gaaattgagg 19260catgtcatgg ctctgtgtgg ggcttgaggc agtccagtgt agtggaggga gggaggctgt 19320ggagcctggc tgcctaggtt caaataccaa ctctgcttat ttccattcat atcattttag 19380gcaaatcact tagccccctg ggcctgcctt tcctcatcag taaaagtggt ataacattag 19440tgcctgcatt gtggggtggt tgtgaggaaa gcagcactca aaacagtacc tgacacacag 19500tgggtgccaa ataagagtct gatgtattag tgttataggt atcggcctcc tccctcccca 19560gtgcaatagt gtgtgtgcgc ctctgtgtac ctctgttggt gctgacaagc cctttttaaa 19620atttagaggt gaggtctcac tctgtcccct aggctggagc acagtggtgc aatcatggct 19680cactgcagcc tcaaccgcct gggctcaagc aatcctccca gcttagcctc ctgagtagtt 19740gggactatcg gtgtgcacca ccacacctgg cccttagaca gcccctttat ttcaaagcga 19800aatggcagcc acaagattta gtgcaagctc tccaagcttt aggaccagct gcaactcctc 19860taactgacca aacaggatcc cccatgtccc caacccccaa aacctgatga aaagcaaaca 19920gaccattttc cacattcatg acggaaaggc ccttttcttg gctcctgccc ttgctcatgt 19980caggatttca ctccatccct gataaagagg aagcaccatg tcccaggagg acatggaaac 20040tctctgcttt gtggtgaata gttacagtaa cagtagctcc tctctgtggg gagcttatga 20100gcccctaagc tttatagaac tgccctggca gtttatgaga acttcatccc agcccccaga 20160gctcatggca cttatttttg cccccagttt gcagatgtgc acactgagac tcagagagct 20220aacactgctt gccaaggtca cacatctagc aaatggagaa actttatgag acaggtgaag 20280gcacagcaag gataaaaacc cagagggaaa aatactcaag ttttctccgg gaaaccattt 20340gcattccaga gaggttggtg tgcgagtggg caagagatgt cgcgggacga tggttaaggg 20400acagagtctg agctcaacta ggactaggtt tcttcctttc cttccttcct tcctttcttc 20460cttccttctt cctttccttt gtctttctct ccctcccttc cttcttcctt tccttccttt 20520cctttctctt tccctccctc cctcccttcc ttcttccttc cttactcctt tccttccttc 20580ctcctttcct tcctttcctt tctctttccc tccttccctc cctcccttct tccttccttt 20640ctttccttcc ttcctttttc ctttctcttt cctttctttc ctttccttcc ttcctctctt 20700cttccttctt ttctttcttt cttttctctt tctttctttc tttctttctt tctttctttc 20760tttctttcct ttctttctct ctctctctct ttctttcctt ctttctcctt ccttccttcc 20820ttcttttctt ttcttttcct ttcttttctt ttgttttttg agatggagtc tcgctctgtt 20880gcccaggctg gagtgcaatg gcacaatctc agctcactgc aacctctgcc tcccggttca 20940agcaattttc ctgccttggc ctcccaagtg gctgggacta caggcacgcg ccaccacacc 21000cagctaattt ttgcattttt agtagagatg gagtttcacc atgttggcca agctggtctc 21060gacctcttga cctcgtgatc ctcctgcctc agcctcccaa agtgctggca ttacaggcgt 21120gagctaccac gcctgggcta ggactaggtt tctatcggtg gtgtggcttt tgggaagcta 21180cctaatctta accactctgt ttcgtcatct ataagataag cagtgtagca ttttcttgca 21240ggaatgttgc aaggattaag tggatggtga ctgtaaaaca tcatgcgtgg cacatagtaa 21300attctcagca ggtagtcatt gctggtcatt tacttttctc taatgaccag caagctctta 21360atttcctcct tggcatgggc actgggacgt agatggacaa aacacagaga gaaataaaca 21420cacggacaaa aatccccgcc ctggtgtggc tgatattctg ggtggggaga gagagggagt 21480ccaaggacca gataaacagg taaaggatag tttgagtgtg gtaagtacta aggctcaaaa 21540ataaagatct cccaggtgat cttagctgca tttggaggtg acaggagata caactgagaa 21600actgagatag gaggaaaccc aaggggagat gtgggcttga tttagggtga tctgaggagt 21660aggagaagtc aggggctggt gtggggaggc tctgatggtt ctctctgggg agtgaagcag 21720ggattcgttg gggagaccca aggggacagg tgaaggcccc tgaacaggtg gccagtgctg 21780agaaaggaaa ggtggaggac ccaagtgagt tcctaatttc ttcattgctc ccctaaggtg 21840tttgtctcac ccttggccat agtcttggat cacttacaga tgcagaccag gctgggctca 21900atggcttgtg cctgtaatcc cagcactttg agaggctgaa cccaggagtt tgagagcagg 21960ctgggcaaca tggtgaaacc ccgtctctac aaaaaaatac aaaaattggc cgagggtgtt 22020ggcacatgcc tgtagtccca gctacttggg aggctgaggt aggaggatct cttgagcccg 22080ggagacctat gctgccaaat aaggtaggca gtagccacac atggctattg caattttaga 22140aattaattac aggccacatg tggtggctca cacctgtaat cccaacactt tgggaggccg 22200aggcgggcag atcatgaggt caggagatcg agatcatcct ggccaacatg gtgaaacccc 22260atctctacta aaaatacaaa aattagctgg gcatggtggt gcacacccgc agtcccagct 22320actcgggaga ctgaggcagg agaattgctt gaacccagga ggcagaggct gcagtgagct 22380gagattgcac cactgcactc cagcctgggc aacagagaga gactccgtct caaaaaaaaa 22440aaaaaaaaaa aaaaaaagaa aagaaaagaa attaattaca ataaaaacag tccctgagtt 22500tcactggcca catttgaagt gcccgatgac cctgtgtggc ttagtgacca ctgtgctgaa 22560tagtgcagat ctagagcatc ctactggaca tgttgccagg gtccctgaac caacagaatt 22620agcatctcct gggagcttgt tggaaatgca gaatctcatc ccctacccca gacctgctca 22680atcccaatct gctcttcagt gagattcctc aggtgatctt gactgcacct tctaatcact 22740tggaagcttt aaaaatgctg aggctgggca cggtggctca cgtgtgtaat cccagcactt 22800taagaggcca aggcgggtgg atcacctgag gtcagaagtt tgagaccagc ctggccaaca 22860tggtgaaact ccatctctac taaaaattac aaaaattacc caggtgtggt ggcacacacc 22920tgtagtccca gctacttggg aggctgaggc aggagaactg cttgaacctg ggaggtggag 22980gttgcagtaa gctgagatgg cactgctgca ctccagcctg ggtgacagag tgggactctg 23040tctcaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaagaaaa aggaaaatgc tgatgcccca 23100agctccaccc ccacagatgc tggagagatt tgtccagggc ttcccctgga gtggggaatg 23160tttgaaaact ccccaagggt ttctaaagtt cagccagagt tagcagaaag cccattaggt 23220ggctaagcag gtagactgaa gttggagctg tgtgaccttg ggcaagccac ttaccctctc 23280tgaaccacaa gctcccttct ctctaaaact agagacctgc tggcacctcc ctcccagggc 23340tgtgagaagt aaatgatggg atgattcaaa gtgctgagta gggtcagatg cagtggctca 23400cacctataat cctagcactt tgggacgctg aaatgggagg attgcttgaa gccaggagtt 23460tgagaccagc ctgggcaaca tttaaacatt acccaggtgt agtggtgcat gcctgtagtc 23520ctagctgctt gggaggccga ggtgggggga tcccttgagc ccaggagttc aaggctgcag 23580tgaacaatga tggtgccact gcactccagc ctgggggaca agagtgagac cctatttcta 23640aaaaagaaag aaacccaaaa tgctgagcga gtgccttgga ttgatagtaa gcagtgcctg 23700tgtaataagc atgaatttta aaaaatgagg tcagcagcct tagagctaat ggttaatggg 23760tttgggtgtg ggattttttt ttttttaatt tttaaaacat tgagataaaa ttcccataac 23820ataaaattga ccattaacca ttttaaagtg tacagtttgg tggcatttaa tacactcagt 23880gttgtgcaac catcacctct ctgtagttca aagaccccaa aaaggagacc ccgtactcac 23940tgagcgctca ctccctgtct ctccccgctc ccccagcccc tggcaactac taatcttctg 24000tctgtataga ttgacctatt ctgattttgg gggtttttga actcgccttc cctggctgac 24060aacctctcgc catccaggtg agactgtgtg aaagcccagc tccctgcatt tctgggtctt 24120cctctcccca ctgggggctg cccccacctg tttccccctc tgggcaccct ggttctactc 24180atcagcctgg cttaatccca gcagcaggtc catgttctgc tctcctgtgg ctgccacaaa 24240tgagaggttt catctcagct gggtttctcc tagttaaata tttaataaat aagacctaca 24300acttgtgatg ctgggagtgt ttgatagtga aattaatgat ggggagagag tggcaggcgg 24360cccacaggtc catgctggag ctgggatgag gcgccctggg caggcgtccg tgccactgat 24420gcttgggaac cacggtgggc catgccatcc catttccccc agccagggcc tcttttttag 24480cactgtgtcc agcacagggt agccacctga taaataagtg ttaaaagaaa gagaggctgc 24540gtgtgtaggg aagaaggaag agacagagga gacaaagagg agacacagag agagagagag 24600agatgagaga gaaagaaaag tggaaggtga gaaagagaca gagatggaag gggagagaag 24660gacctggatg gaggaagtgc aaggaaggca atggtgaggg aaaagagaga gagacaaaga 24720tggaagggat gaaggagagg gagagatatg gaggtagaga aagagagaca gaaagaagag 24780agagaatatt gcttcttgta tcttcccctt ctcctgttat ccttgaccat cttattattt 24840ttttcttttt tctgtctctc cagttctcat ttccttaccc tcgccgtctt gccaactcgt 24900catctctttt catttcctgt gtctatgtta tcttttaatt ttctgtctgg gtattttccc 24960cttttctctt tctcagcata aactgttggt tggtgtatgt gtcttctttc ttttttagtc 25020tttaactgac gtgtgtgtgt atgtgtgtgt gtgagagaga gagagacaga cagacagaga 25080gagagagaga gagacagaac aaacctagag agcagtgtag gaacatagat gaacatttta 25140aagaccaaac catgaagcgt acacccattt tacccaggtc aagagccaca gggccaccat 25200cagattctcc ctcatgctca tcctcaatca cagccactcc ttccctcctg gaggaaccac 25260tattggagat tgtatgggaa ccattcgctt gctttcttgt gtggttgtac cacctaagta 25320cgcatcctga agcaatatag tcagatatta tgtggttttg agttttatat gaataaaatc 25380atgtgagagg agttgttttg tattttgctt cattggtttg cagttacctt tgtgagattt 25440catcctcatt gtggtcactg cagctccttc atgatcttgt ttattcattg atgatgagca 25500tgtgactttg ttctcttttg ggcactggca taagcagctt tgttggttgt ttatggattc 25560tgctgctcgc ttgcaggggt ctctctggag cacatcgctc tgtgtgaaat tgttggatac 25620taagatttgt acattttcac cttgactaaa cactgccaaa caattttcca aagtgcttgt 25680gctaatttac actcctgccg gtggtgggtg agcattcaag atgcttcaca accttgccaa 25740cacttggtat tgtcaggttt ttaagttata gcctttctca tggtgatttc tcattgtgat 25800tttagtttgc atcccccgat tgcaaattag agtgaacata gtttaaaata tttattgact 25860attcaagctt gcttttttgt gaagtgcctc tacatgctct gtccattttt gattaggtca 25920cttttaaaaa aaaaatattg atttgtgggt gatccttaca tagcctggaa actgattctt 25980catcattata tgttgtgcaa tattttctct tggcttggct tttgatcttt tttataatgt 26040cttttgatca ccaacagttc ttaattttga tgtggttgat tttagaaatc ttttccttta 26100tagtttgtgg gctttgtatc ttatttaaga aaatcatttc taccctgagg ccatggatat 26160attttatgtt atttctgaaa gttttacagt tgtgttcact gtatgtcttt aatcagcttg 26220ggattgattt ttatatgtgg tggtaggtag gggtccaatt tcctttttat tccataagaa 26280ttgtcccagc atcatttatt aaaaagccca ttcttgcccc aatgatctgc aagacaacct 26340cttgactgtt taacttttac cttctttcat ctggtctgtt tttatactca acctttgaag 26400ccacaaatat ttattgagtg ccaactgtgt gccaggcact gagttacagt gacggatatg 26460acagatgcaa tcatggcttt catggagttt acagtctggc aaggatgaca tgtaaatagt 26520tattactact tataatttaa aatgttatag gccttgcaaa aagggacaag tctggcttgc 26580tctaaaagaa acatgtgaaa caacatcttc cagggaagtg ctgataaact gagtctttag 26640tgggcctctg ctattgtagg ggtgggaatg gtggaaaaga tgttttggcc acagggaaca 26700gcatgtgcaa aggtcctgtg gaaggtgctt aggagtttga tatttatcct aaaggcactg 26760tcaggctact gaagcagtaa tacaatgatt ttatgtctgt gaatagttcc actggttgct 26820gcatggagaa tgtattggaa tacagcaaga ataaaaagcc atgagaccaa ttaggaaatg 26880atttcactca ttcagggaag tgtgccttgg gctggcatgg tggctgtgga gatggaaatc 26940attgatcaga ttaaaagaaa ttttgagctg gcatgatttt tcccctctct cccctctctc 27000tatctctgtt tcttttctgg ttgtgttttc tgggtgagaa aagcagtttg tgatcctgcc 27060aagggtatgt gctctggagg atgtatttgc cacagatggt ctttggaatt ctggccaaga 27120gagtcactgg acagcccctg gcccccaggg tttctggagc caattcaaca atgactgttt 27180attaacaaca gcaaggatga gttgctagcc tttccttcag agcacctttt aactgttacc 27240ttactttgtt acccaaaccg acactatgga attggtgggg gagaagtgga agggttttta 27300tctccatttt ttatagaacg ggggaagtta attggcactc ttgaaatcat acaaaagatg 27360ttggtttcag gattggtttc tggactttca gcccaatccc aattactcaa gctcacacac 27420ccaatcccca aacatactct tttgcaaata atttccctac tgaggtgctc ctggccaatt 27480taaaaggtcc ccatttcctt gcctataaaa tgggaattaa agtaaaaata tctacctgtt 27540gacttgctgt gaggtcagtg ggcctgacac atggtgtgga ctcattatat ttacctatgt 27600gaatccctta gttcccttta cttggaagag gtggaaaact caaaggggct taaacaagaa 27660gtggggattg tattggctca tgagactgaa gagtctcagg agtgtccagc ttcaggcttg 27720tttggatcta gggatcagat aacaccatta ggcctctgtt tctgtttctt ggctctactt 27780tttgcagctg gctccattat ccatgactta gctgcacttc cagccctcca gtctgcccaa 27840gaccatattc agagagagat tcttctctct ttttcagcta tcttcccgga attttcagca 27900aatgctttct tgcttttgat tggctgttgc tgaggtcgtg tgctcatgcc agaaccaatc 27960actgtgggga aatgggaggt ggagaacggg gtgctctgat tggcttaggc ttgggtcaca 28020tgactttatg gagttggggt ggagccaact tctccaagtg gggaagagca gtcttcttaa 28080aggtgtatta ggatatgctt gctgctgtaa caagcaaccc ccaagtctgc agtagcttaa 28140ggcaatacga atgtacttct cactcaccct aaatccaatc agataatcag caagtggcat 28200tccatgtggt gatttcagga cccggctctt tccatctgtg gctccaccat cccctaagat 28260cagaaagtcc ttcacttccg gcctgtagga aaagagtatg aaggctcaca caggaagttt 28320tgggaggcca catatagaag tagtgaacct tacttctgcc tgcattctgt ggactggaat 28380ttcatcccat ggtgtatgag agagggtccc agtaggaaac ggaagacaca gaccaagaat 28440caaattaaga gatagcttaa gaatcaaatt aagagatagc ttacaaaggt gtgggccctt 28500actgaaatag agaaggagga agagaggaag gaggcagaga cagagagaga ctgagactca 28560caaagacaca cacacacaca cacacacaca cacacacaca cacacacaca caagttgaga 28620gaaagaaggg gggagagaaa gagagagagg gagcatttcc taacaggaag ctggcagaat 28680aaatgtcccc cattgtccaa agccagaggg ctgggagccc agtgagccca tccacacagg 28740tcagcccccc atgtgacagt cctagaaggg taaagaagga aggagagtgg atttggggta 28800atggaagaca gccaataccc atggtccatc tgactgcagg gggaactgag aaattcagtc 28860catggagaag aaggtttagt ggacacgtca ctttgtcttt ttcacaaagt gaaactaggt 28920tctcaggtgg aaaaaagaaa aagaaggttt gccttgctgc tattcttttt ttttttttga 28980gacggagtct cactctgtca cccaagcggg agtgcagtgg cacgatctcg gctcactgga 29040agctctgcct cctgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta 29100caggcaccca ccaccacgcc cggctagttt ttttgtattt tagtagagac ggggtttcac 29160tgctagccag gatggtctcg atctcctgac ctcgtgatcc gcccgcctca gcctcccaaa 29220atgctgggat tacagacgtg agccaccgca cccggcctcc ttactgctat tcttattatt 29280ggtggtagca gtggtggtga tggttattgg ttcttagttc cctctacatg ccagtatctg 29340ctctcttctt tttttctccc ttacttcttt ccttgttctg caaattcttt ccctttaagt 29400gaaaatcttt ccgtgttctc caagggagat aaattctatg ccaagcttga gtgtggggtc 29460ctctgcttgg atagctgtct tctccaggag atgaggtaga actgagatag tgggggtctc 29520tgcaggcagt ctgtgcccct ggcaagcccc tcaccttaac ctgaggctgg gtggggaaag 29580atgccttgat ggagtcagaa cagaaagcaa gtgatcgctg cctgaaccaa gcagtcactt 29640tcctggaggt gaaacctaga aacggtccct caggctgggt ccagggaggt ggacttgggt 29700cccaggggca ggaagcaacc tgcccctcac ctgctcctac ctctttgtag cctatcttgg 29760caaccagaag taggtataca agtgacgttg aagctgggca tgttaacaat ggtgtgagcc 29820cgcctgactc caatctggtc cagctgtact ggccgtgcat cctcatctcc agcccccagg 29880gtcagcccag cggctgtaac aatggtctgt cccctccccg ccccacccac ttctttgaac 29940tcctccaagg atctgtgatg atagggctgt cactgtctta gcttccacca ttcaagctta 30000accggccttc ttcccctcca tggagaacgg aagagcaacc cctcattgcc tctggcagct 30060gaccagcagg tccctgcctt ctgcccactc ccaggtctag

gacaatgagg tgagaggtag 30120acaggaccaa gttccccagt gctgtcttct aggtccacct atcatgagag ccgtgattcc 30180tagtttttat caccctctcc ccaactttgc cagctctcca cttctggcag tggtggctgc 30240ccatgacttc accttcccgt gcctcagttt cctcatctgt aaaataagga cagccatggt 30300aatgagagtt ctggtcaata tgccaggcac ctcgcttgca tcaatttagc tcatcctttc 30360agtgccctga ggggtgggta ctgttatcat cccgtgtaac aaaaagagaa aaccgaaaca 30420gagagagaga ctcactatct gaggtcttgc acccctcaag caacaaaagt gggatttcag 30480cctaggctat ctagattcgg agtccacggt ctcaatgaat aataacaaca ataataatat 30540tgtcctaatc tgatgagttt ttgatcagat tcaatacaag agcataggca gaaaagctta 30600gcccagtgcc cagcacatgg taagaactca gcatgttatt tataatagta ataaaccatt 30660ttatgttatg taattatata ttcatagata aatatagttg actcttgaac aacatagggg 30720ttggggcaat gacctcctgt gcagtcaaaa atgtgtgtgt aacttttttt ctctattttt 30780tagaaatttt aaaattagag acaaggtctc gcttttgttg ctcaggttga tctcgaactc 30840ctgggctcaa gtgatcctcc tgcctcagcc tctcaaagtg ctaggattac aggtgtgagc 30900ccccgcaccc agcctgtgta taacttctga ctcccccaaa gcttaactac taacagtcta 30960ttcttgacca gaagccttac cagtaacata aacagtcgat gaagacagat tttatatgtt 31020atatgcatta tatactgtat tcttacaata aagtaagcta gggaggagaa agtattattt 31080taagaaaatc ataaggaaga gaaaatatat ttactattca ttaattggaa agggatcatt 31140ataaaggtct tcatcctcat tgtcttcaca ttaagtaggc tgaagaagag gaggagttgg 31200tcttgttgtc tcaggggtgg cagaggtgga ggtggaaggg gaggccagaa agacaagcac 31260gcttggtgta actgttattg gaaacaaatc tacataagtg gacccataaa attcaaacct 31320gagttgttca ggggtcaact atatatgcta caaatacgta atatgctaat atagttgtat 31380gttattgtta tagtacgggg atcagaaaat gttttctgca aaggattagc tagaaaatgt 31440ctagtaaata ctgtctcttt gggaccactc tactctgcca ttatagcaaa ggcagctaca 31500ggcaatacgt aaatgaatgg gcatggccat ttgccaataa aactttgttt acacaaacaa 31560gccatgggcc agagtttgtc aacggctggt atagtatatg ttattatata ttagctttac 31620tttttctgtt gctttgttta tgttcttctt tgcccttcct ttcttaaagg ccagcctttc 31680tttctctctg ttggtctgtc ttttaggaca gcatggcagg ccactgggac atgggctctc 31740ctgactccag gcttgtttgt ctgataagac atgaagagtg aaggtggcag gactctgagc 31800tcaggcctgt cctcctcctc ttccctctct tcgttttttc tttcctcttt cctcttttct 31860tcccaagctc cagaagttgc cattttcctt tcccattgct gattttctct gccttgggag 31920aaagcccgag aagatcactt ggaaaagccc acgagcatct ctggcctcac tcacccagct 31980cctgccattg tctttactct tcctcagaca caccaggcac agtcctacct cagggccttt 32040gcactggctg tttcctctgt ctgcattgtt cttctctcag gtgacctcat ggcttctccc 32100tcctctcctt caggacttca ctcaaaggcc accttctcag catttgcctc ccgcccttct 32160gccttatttt cccctttgga acttttcacc ttcttactta ctcatctgtc tgctatctgt 32220caccctacat cactatgatc tccacaaggg aaggtgattt tattcgtttt ttgttctgtt 32280ttgttgaaga tgaggttttg ctcttgttac ccaggctgga gtgtggtggc acgatctggg 32340ctcactgcaa cctccacctc ccggattcaa gtgagtctcc tgcctcagcc tcctgagtag 32400ctgggattac aggcacccac caccatgcct ggctaatttt tgtattttta gtacagatgg 32460ggtttcacca tgttggccag gctgatctca aactcctgac ctcaggtgat ccacccacct 32520cagccttcca aagtgctggg attactgtga gccaccacac ctgatctttt ggttttaccc 32580accaatgtgg actagaacag cctagatcag caggtggcat gcagtaagca gttgataaat 32640atgtgttgga tgagtgagca ctgtggcttc tgtcattctg ttgctcaata gcattcatct 32700ggaaataacc acagtttgtt tatccattta cctgttgatt ggcatttctg ttgattctcg 32760tttgggccat tatgaacaaa gctgctgtga aatacttata cctttgccca attcttcact 32820tggtgaaccc ttataaatcc tttaggccag gtgtggtagc tcacgcttgt aaccccagca 32880ctttgggaag ccgaggtagg aggatcgctg gaggccagga gttcaaaacc agcctgggta 32940acatagcaag acccgtctct acaaaaaaat aaaaaattgg ctggacgtgg caatgcatgc 33000ctgtagttcc agctacttag gaggctgagg tgggaagagt gcctgagccc aggagttcaa 33060gaccgcagtg agtgatcgcg tcctgcactc caggctgggc gatagagtga gaccctgtct 33120gtaaaaatga cagcaacaac aacaataata aaacctttag gtttcctctt aaaaggaaca 33180tccttagagc ttttcctgac ccagcaactc accccaagtc tgaattagac ttcaccccat 33240ttctttcata acatttatca caatgacatg tttattttgt gggggcgggt ggcattctgg 33300ccagaactgt cgacttccag agtgaaaata cggaagaacc aaataaaaca caacacacac 33360atttgcacag cagctcgagg gaggtgctta gttctttgag tttccaagaa cagagagacg 33420aagatttgtc tggggaggaa aaatcaggga ctgcttcttg gaggaggtgg actgttgctg 33480ccccatccac ccacacattt gcagatgtgg tgatgagaag atgactgtca cgaggtctct 33540gagcccaggg ggcccatggt tgagtgcaaa gatagtgggg ttgacaaata atcgtcgtat 33600aacaaaagaa aagccaccac agttgcataa tggaaaggcg gcttctatag aacattcaga 33660tcatagttga aggcatgtca cactgtgtta ctcagaggcc actgtcagag ccaaaagtga 33720gagtggatga gagtttgggc aggaaacaac tgaaccagat acagcatcac ctccatgagg 33780gctcagcttt atctattttg tcttctgttg catccccagc ccttagaaca ctgcctggtc 33840catctttgct gtgtgaataa taataaggaa cgatcgctgt gttgagtttg ggctgtgaat 33900tcagacagtt tgctgctgca tacctgatta tgagtctcag ttttcctcct ccataaaatg 33960ggcaaaacag tccttgcctc atggggctgt gcatttgttt agcaaacact gaaggagtat 34020acatggtggc caaggcactc ttcaagacac aggaagcaga caaaagtccc tgccctctgg 34080gagcttacat gctcatgggg agagatgtat gataagaaac aaaaatagta ggtaagttgc 34140atagtacttt agaagattat aagggtaatg ggaagagaac agcagagaaa gggctgggga 34200ggcagttgct gtattagata gagctttatc gaggcgatgg cattggagcc aagacttgag 34260gaagctgtga ggatgtctag agaaagaagg aacagctggt gcaaaggccc tgaggtaggg 34320gtatatgtga catgtgtgac agtgaggagg cagatgtggc tgaagccagt gagcaagaga 34380gagggaaggt gcaaggataa ggacagagag gtgacgggac aggttttgga gggccttatg 34440ggctgcgggg aggactttgg cttttgctct gagggagctg ggagccacgg agggcttttg 34500agcagaggag ggacgtgacc tgactcagat attcataggc tcctctggct gctgtgaaaa 34560gaacagactt tgaaggttgg gggcaggcag ggcagaagct ggggaattag gaaggaggtg 34620acagtgttgg tcctggcagg taatagtggg ggtggaacca ggttgttgtc tgtggagata 34680ataatgagtg gctggattct ggttataatt tttaagtttt tttattgtga taaaatgaat 34740ttttttattg tgataaaatg aaatttacca ctttgaggtg tgcaattcca cagcacttac 34800tacagtcacc ctgttatgca acagtcacct ctatttaatc tcagaacatt tcatcccccc 34860taaaggaaac cctgcaccca ttagtagtta cttccagttt ctcccttccc ccagcttctg 34920gaaactacta attctggata taagttgaaa gttgaccagt aggatttcta ggcagacagg 34980tggtgagggc tcaatgcatt catgcacaga aagtactcag gtggcatatc ataggtgctc 35040aaaactgaaa tggtgatgat gagttggcaa tgatggtgag tccttccaga atccctgctc 35100tagtgctaaa ctgacctacc tggctgtgta gaattctcac ctgctggccg ggagggtggc 35160agaaccagga tcccttctta cttccagtct ggcttgggtt agggataggg gaggaatgat 35220cagaagaacc aagctagcac catctgttct ggaacatcat ccaactcttg tccagatttc 35280ccagaactga gcaggaaaat gtccagggag gaacagtgca gctgatggaa gtcctggtaa 35340gccctggccc cagcttcctg agctgctgtt gcaccaacta gcatttgttg gaccttcagt 35400ctgagccaag atggcagctt cagaggaaga acaagaagtg tacaagtttc tttcatggtt 35460gtgtccccgc ctccttatat agcctcatat aaacccctgc actatcccgt tactgtttgc 35520ctctccctga aaagagtgta aaactccccc actttttccc tacttttcac aatgtgtttt 35580ggtttctaaa gatgaaactc ctttaattat gttctggttg taattttctg gctcctttta 35640tttctccctt acttgatgta ttattttccc ttgttccttc tgccccctgc ctccattgat 35700gtttctcttc actgctatct agatttaatt ctcaactcct gccaagttca gggtgatagt 35760gcaaaaagac atggaccatt tagtcttgaa ttcaggtccc acttctgaca ccttcaaagc 35820tgctttactt tgggcaagtc atatgatctt cctgaggggg tatcctttac cttgttcagc 35880taacatttct tgtttttctc tgggcacaga gtagagtgtc attttcccca cctccctgaa 35940gttaggtatg gctgtgtgat ttggtttcat caatgaaatg tgaggggaag tgacgtgagt 36000ccttccggac agaagcctta agggtgagca tgggattcac catgtttcct ttttcctgcc 36060tccactgtca tggatgcaca aagatggacc ctctctcaaa gtaagtgctg gagagaggat 36120gacatagatc agtccccatc ccacttcata gcatgagtag aaaaatagac ctggggtgtg 36180ttcaaccact gagatctggg gattgtttgt tactgcagca ggacatagac taggctgact 36240gtatacctca ttatctgcat tttggggctg atatctaatc acagtgtctc caggaagatt 36300atgttgatgt atgttttagg gatggatatt catattttcc tataagggct caataggttt 36360ggaaatgtca catgcatgta aacttctgat taacaaatat ttcttgcttt ccaatttctt 36420cctatagtgc ttctaatttt cctgtttttc aatcttgaat aaaatgtgag aagtgtttga 36480cttctccttc gaggagatta atggtttcta aagcctgggg cattgattta gtcattctca 36540acctccttgt ttctatgacc tttttttctc cttctctggt cacttagtgt ctgctaaggg 36600gtgaaggaat gtctgtttta actcattgca tttttttttt ttttgagacg gagtctccct 36660ctgttgccca ggctggagtg cagtggtgtg atgttggctc actgcaacct ctgcctcctg 36720ggttcaagtg attctcctgc ctcagcatcc caagtagctg ggactacagg tgtctgccac 36780cactcccggc taatttttgt atttttagta gagacggggt ttcaccatat tggccaggct 36840ggtctcgaac tcctgacctt gtgatccgcc cgccttggcc tcccaaagtg ctgggattac 36900aggcgtaagc caccacacct ggcaaactct ttgcattttt aactcttgac atcttcatct 36960tctttttccc acctcccctt tgcctgttcc tcccctgctc accccaccag ggagtttata 37020atcaggttct agaacctgca atgtttttct gttgttgtct tccatcttcc ttgagtctta 37080tgggaatcgg ccatagtcgc aaattaacaa atagctctga agcgcctcaa gcttggaggc 37140atttcctttt gctcacctaa gcaagatcct ggagctgttg caaatatcct gccccctact 37200gtaaatctgt cttcatggtt gtaagagatt cagtcggggt cagtgaagac ccgagcagga 37260gatcttggcc gaggctcctt gatgttctgt ctgcgctggg tgttgtcata ttgattaagc 37320tcctgggact gctgccagca gcctctagga ttaaatcaat agagtttgca aaagtaaaag 37380cttcttttgg agacacagaa tatgtgggtt tattttttaa tgataaagct tcaaggagaa 37440tcttcatgga tggcagaacc agtgatggaa aaggcgaggc agacccaaat atttggggaa 37500gtgcagtggg gagcaagtga gggaggtttc attgggaggc cggggctttc cagaaaatct 37560gtttaactgg agttgctaat gcaacagctc agagttagaa gtgaaggtgg aagatgcaag 37620aaggactgcc gctgagatgt aaagagaaat gaaggagagg tggatccatt tgctcattca 37680ataaacattt tgggaggcag gggggtgggg gggagcctgc catgtgcctg gaactgggat 37740gtacatggtg gggacatgac agtgggcagg acagatgtgg ttcctcctgg ccctcctgga 37800acttgtaaca ggaaaagaag gcataaaata aggaataggc aaatacagac ataattacta 37860attgtggtaa gtgtttggga gaaaaccagc agggtcctgt gtttgtttcc tagggctgcc 37920aggacaaatt gccatgaact atatggctta aaacaacata aatatattgt cacccagttc 37980tgaaggctgg aagaccaaaa tcaaggcatc agcagtgctg agctcccttg gacggctcta 38040gagaagaatg cttccttgat tcttccagtt tctggtagtt gttagcatac attggcttga 38100ttggcttgtg gctgcatcac tgcagtctct gcctctgtct tcacatggcc ttctccttca 38160tgtcagtgtc ttctcttcct cttctctctc tctctttttt ttttttttgt cagggcctca 38220ctctgtcacc ctgtacaaga gtacagcagt gcaattatag ctcactgcaa ctgctgcttc 38280ccagcatcaa acaatcctcc cacctcagcc tcctgagcag ctgggactta caggcgtgca 38340ccaccatact cagctaattt ttaaattttt gatagagatg ggatctcact atattgccca 38400gactggtctt gaacttctgg gctcaagtga tcctccctcc tcagcctccc gaagtgctgg 38460gattacaggt gtgagccact gcacctggcc tcttctgtct cttataagga tctttgtcga 38520tggattttga gcccgtcaga taatccagga caatctcatc ttgagatctc taatttaatt 38580atacttgcag aggccgtttt actaaataag gtcatggcca gaggctccag aggctaaagc 38640atgggtatga ttgcaccact gcactttagg ctgggtgaca gagcaaggcc ccatctctga 38700aaaataaaat aaaataagta acctactaca ggccctttgc gtagaggata attagaagta 38760caggggtacc acgtaagtga agacctgaag gttgttaagc acagagcaga gtgtgaacag 38820aatgagacag agggaggaag agaatcccag gcagagggaa cagcatgtgc aaaggccctg 38880gggaaggaac aagttcatca tgttaaaaat gagccagtgt agctagagtc tgatgagcaa 38940agggactcac aggtgggaag acacccaaga agttggcaga gacaggtcac acaagacctt 39000ctaggtcaag ttccggaggt gaactttatt ctacatgcaa tgagaagtcc tcagagaagc 39060ttaagtggga tgggacagaa ctgctttact ttaaatatat atacatatat acaaacatat 39120aatattacat atataaagca tatatatgta tacatatata catatctatc tacctgtcta 39180tatatttttt agctgggcat ggtggctcac acctgtgatc ctagcacttt gggaggctga 39240ggtgggagga tcacttgagc ccaggagttc aagaccagcc tgggcaacat agggagaccc 39300catcactaca aataaaaata aaaattaaaa attagctggg tgtgatagtg tgcacctgta 39360gtcccagcta cccgggaggc tgaggtagga ggattgctgg agccccaaag gttgaggctc 39420cagtaagccg tgattgtgcc cctgcactct agcttgagca acagagtgag atcctgtctc 39480aataaaataa tttttgtatt gaggtgaaat tcatgcaaca taagttaacc attttaaaat 39540gagcaattca gtggcattca gcgcattcac aatattgtac aacctccacc tctttctagt 39600gctgaaatat tttcatcacc acccctccag aaaaccctgt atccatgagg cagttgctcc 39660tcatcctccc ctcccggtat ccccccaacc cccaccactc ctggtaacta caaatttgtt 39720ttctgtttct atggatttac ctatactggc tctttcatat aaatgaattc aggcactgtg 39780tgacctttcg tgtctggctt ctttcactta gcataatgcc ctggcttctc tctggagaat 39840gaaatggata gaccactttg gagtctactg agattataga tatttctgtg ggaagggaca 39900gtggcttgac cttgggtggt gctgaagagg caatgctgag caggaggatt caaagtctaa 39960tttcggaagt agaattggtg gggtctgatg atacatcagc tgtaggggga ggaagatgta 40020ggaactggga aggtctctta gggtaacctt acctgattga gctccttact aggcagctgg 40080tggtacaatt cataacaaag gttaatagag aaagagacat gggattaggg agggaatgga 40140agagtttggg ccttggacac tgtagtggtt tgaatcctgt ccaccaaaaa ttcagatgca 40200tttggaactt cagaacctga gacctcattt gaaagtagga tctttgcaga tgtcattgag 40260tcagggattg agatgaggtc atcctggatt acagtggact cgagattcca tggtaagtgc 40320ttttatatga gaaggtacag gggagaaagt catgtggcaa tagaagcaga gaatggagtg 40380ctgcagccac aagccaaaag acatgtagag gcaccaaaag cgggaagagg caaggaagga 40440tcctccccta gagcctttga agggaaaccc cctaatttca gaaccttgcc tccaggatga 40500cgagagaata aatttctgtt gttttaagcc acccaatctg tggcaatttg tcatgactgc 40560cctaggagac taatatagac actcctatga gatgctctaa gaagacacag agtggtatag 40620ctattgctaa gaccacacac tgtagcaggg aggaaatcaa atggagaaat gccccaactc 40680cccctcctct ctgatctctt gctggtgcct cccgttggcc aagccaaccc agaaggcaga 40740agatgtggtg gagggcagcg ttgcagggct tggatgatgc agtcacagaa gtcagccctg 40800cctctaccag gatgccaaac agggcaatga gtggatattt tagggagaaa gggcaacaag 40860agaatggcaa aatacatcga aatgcatgca agctctagaa agaggataga gatagataaa 40920gggtgattac ctaggattaa gccccaggga agaccaacat ttagagattg gatagaaaaa 40980gaggagcaaa aagggaagat tgagaagtag agaccaggag gataggagga aaactagaac 41040aacattaaga agggcatggt caagtaatct gggcacagaa aaatggccct gggatttggc 41100agcctggggg tctttggtga tcctctttgg aagagttttg gttgagtgat gggggctaga 41160aaccagcctg gggagggtag gagaagaatg tgcagtgagg aagtggcagg aacacgtgaa 41220ggcaactctt catgaagggg agtagagaaa ttggttggtg gctgaaggaa aattttcagt 41280caagggtgga ggttttaatg atggaagaat attgatttct gtaaattggg tcattcccat 41340ccattatacc aatatgcacg ggtgtcttct ctgatatagg atgctgggat tctcaaatgc 41400ccatttgagt ttagcatcat gaatttaatg tcaccagccc agatagttga tctcattcag 41460gaatgctcca ctgcccaggt atggggaagg caactagttg agttcatgca gggatggatt 41520ttttccagga gagaaacagg aggcaagaaa gtgcgatata atcaacctat gtaaggttga 41580caaggcagga gagggtcctg agaaatggcg gggtcagtgg gttgcagggc tcgatgggat 41640ggacgttggt ttgcatttaa gggagttagt gagctgggag gtggttaaag aggaggtggt 41700tcagccgggc gcggtggccc acacctgtaa tcgcagcact ttggggagcc gaggcgggcg 41760gatcacaagg tcaggcgatc gagaccatcc tggctaacac ggtgaaaccc tgtctctact 41820aaaaatacaa aaaaaaaaaa aaaaattagc caggcgtggt ggcgggcgcc tgtagtccca 41880gctactcagg agcctgaggc aggagaatgg cgtgaacccg ggaggcggag ctgctgtact 41940ccagcctggg cgacagggcg agactccgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa 42000gaggtggttc aagacaagga tgctggaaac aggtgttttg gaggtggctg gtgtagcttc 42060tgagcatgca tagctggagt ggcttggagg agacattggt tattgatgaa gaggtaggga 42120catcctccag tgatcaagga agcaggggac cagcatggac aatggtctct ccacagggaa 42180attggaggtc atcaaatgtt aacaggttcc gtcggagtct tagctcccag cttctgtttt 42240cctgtggatc tcaggatctt ggctgctggt gctacctctg actttggact tcccattgag 42300cccagcagca ctgggaggga ccttcatggc attggctggt ttaaggaaga cttccttggc 42360tttgctgact ttcttggggg ccttcttggc tacacctgct tttgagggag ccctcctcac 42420ctcacctgac ttcttggggg caccttttcc accttatctg agttgggaag gtctttcttt 42480gattctcttg ctttcttggg gcccttctca ctggtttttc tgggggccat gatggtggac 42540atattccaga gctgagcttt ccttttgttc ttaggaacta atttgaggct gccagtggcc 42600ccaccttggt cttagagttg atggtctgca gggaatttcc aggttaaagg ttttttattt 42660gtttgtttaa ttttgagaca gagtcttgct ctgtcaccca ggttggagtg cagcggcacg 42720atcttggctc actgcagcct ccgcctcctg ggttcaaaca gttttcctgc ctcagcctcc 42780taagtagctg ggattacaag cacgcaccac catgcccagc taacttttgt atttttagtg 42840gagacagggt ttcaccatgt tgaccaagct ggtctcaaac tcctgatctg aagtgatccg 42900gccaccttgg cctcccaaag tgctgggatt acaggtgtga gccactgcgc ctgacctcca 42960ggtttaagtt taaaccatga agtagatgga ctgtgtagag agagaccagg gaaatggagg 43020attttactga ccactgaaca gggatgtcac tattgccaga gaggaaaagg attccccctt 43080ggtagagtga acatataagg gaaagtggtt gaaaattgaa tcaggagaca gagacctcac 43140accactcaga ggtccctaga gaactttact gacctagaaa aaaagataaa cagggagaag 43200gtcttcagtt cttgtttgga atctgacact gaagcatcct cactcctcac tctcttcccg 43260accccgagag tctgaaattg attaatactt tttgtttaaa acttggcttg ttgttttgtt 43320ttttctttct gttttcatca agggatcttt attttacttt tgtgtatttg tgtgttttcc 43380atgagtcatg ttaattcttc catgtttaaa ctttttggcc cagaggaatt tatacattta 43440aattatggat ttaatttcag aaggtacata cacacacaca cacacacact cactcatctc 43500actttttaaa aactgtaaaa tatagccctg taaatatcca gaaaatatct aatgtgggcc 43560gggtatggtg gctcatgcct gtaatctcag cactttggga ggccgaggtg ggtggatcac 43620ctgaggtcag gagttcgaga ctagcctggc caacgtggtg aaaccctatc ctcactaaaa 43680ataaaaaaat tagctgggca tggtggcagg tgcctgtaat cccagctact cgggaggatg 43740agacaggaga atcacttgaa cccaggaggc agaggctgca gtgagccgag atcaccccac 43800tgcgccccag cctgggcgac agactgagac tctgtctcac aaaaaaaaaa aaagaaaaga 43860aaaagtcagt gtgcatcccc tctgacatcc agcaacttca catcttggaa tttatgctgc 43920aggaaaatta tcacaagtgc acaaggatgt atggtgagat agttattatt atcattttaa 43980aagatagggt ctcactgtgt cacccaggct ggagtgcagt gaagtgatca cagctcactg 44040cagccttgac cttctgggct cgagtgatcc tcgtgcctca gcctccccag tagctgggat 44100tacaggtgtg agccaccatg cctggcatcc cccttttttt aaaaaaaggt tttaattatg 44160aaaagaatat gggcttgttg ttttgtgtgg ttttttaaaa gcttaaaaaa tgtgtagtgt 44220gtcatttaga aggtgaaaag cccttacccc atcccacctc ccagagataa cctctgctag 44280caatttcgtg tttgtctttc aaattttttc ccacacacat tctttgtact ggctgcttcc 44340cctcctgggt tactcttctc ccagacagaa acagggctca ttcccttgcc tcctccagct 44400tttattaaaa cattaacttc cctgtagctg gatgcagtgg ctcacgcctg taatcccagt 44460gttttgggag gtggggaggc aggaggatag cttgagccca ggagtttgag actagcctgg 44520gcaacatagc gagacccatc tctacaaata aataaataaa taaataaata aataaataaa 44580taatggaaat ttaaaagaga gagggaagga ctcttgaaaa ccgtccatat catgcttctc 44640taaatggttg agggctcaga ggaaaaaaaa tcagcaattt cacatcacgg aatttattct 44700gcagaaaaat tctcacaagt gcacaaggat gcgtggtcag atgatgatga tgatgattat 44760tattattatt attgaagaaa gtagcagcag cagcagcagt attttaaaag acagagtctc 44820ggatgggcat ggtggctcac gcctgtaatc ccagcacttt gggaggttga ggtgggcaga 44880tcacttgagg tcaggagttc gagaccagtc tggccaacat ggtgaaaccc caactctact 44940aaaaatgcaa aaattagcca ggtatggtgg tgggtgcctg cagtcccagc taccagggag 45000gctgaggcac gagaatagct tgaacccagg aaatggaggc tgcagtgagc caagatcgtg 45060ccactgcact ccatgcactc cagcctgggt gctgacccag gttaggtgca agactccgtc 45120ttaaaaaaaa agaaaaggaa aaaaaaaaaa aaaggacaga

gcctcactgt gtcgcccagg 45180gtaaagtgca atgagtaaag gcccatgatg ggaaccctga ggagagagtc aaggggaaag 45240aaaaaaaaaa aagcaaaacc aaaatggaat ttaaaaaaaa tcaggtgcaa tttgcataac 45300agaaaattaa ccattttaaa gtgaacggct ctgtggcatt tactgcactc caactgttat 45360gtaactacca cctctgtcta gctccagaac attttcacca cccctaaagg agaccttgta 45420cccattaagc agtctctctc cttctcccct ccccaccacc ttcctccagc ctctggcaac 45480cacccatctg cattctgtct ctatggattt acctattcta ggtagtcaac aggatgagat 45540atcccaaaag tccatccatg gatgaacaga taaaccaagt gtgatatgcc ttcctcagat 45600attagtctgc cttaaaaagg aatgaaatac taatctttgc tacaacatag atgaacctca 45660aaaatatgat gtggctggac acagtggctt acacctgtaa tcccagaact ttgggaggct 45720gaggtgggcg gatcgcttga gcccaggtgt tcaagaccac cctgggtaac atagcaaaac 45780tccatctcta caaaacaatt tacaaaaaac tagccaggtg tggtgacatg tgcctgtagt 45840cccagctatt caggagactg aggcgagagg atcgattgag cccaggaggc cgaggctgca 45900gtgagccatg atcataccac tgcactccag cctaggcaac agagtgagac cctatctcaa 45960aaaacaaaac aaaacaaaac aaaaaagttg atgctgagtg aaagaagcca gacacaaaag 46020gcaacatcgt gtttaattcc atttacatga aatgtccaat gaagattttt tttggcaaca 46080tttattttga gtataatatt cagtgagtgg accacacata tgcatgcact gcagtatgtt 46140cttggaaaca tttcagattt gagaggtctg ttcagctatg atgacggtag gtattgtccc 46200ttccctccct ccttgaagaa aaggaactaa ggctggacgc ggtggctcat gcctgtaatc 46260ccagtacttt gggaggctga ggtgggcaga tcacttgagg tcaggagttc aagactagcc 46320tggccaacat ggtgaaacca tgtctctact aaaaaataca aaaaattagc caggtatggt 46380gctgcacgcc tgtagtccca gctactcggg aggctgaggc aggagaattg ctcgcaccca 46440ggaggtggag gctgcagtca accgagattg caccattgca ctccagcctg ggtggcagag 46500caagactctg tctcaaaaag aaaagagaag agaagagaaa agaaaagaaa ccaaaagaaa 46560aggaaagaaa agaaaaggaa ccaagaccta gaagggcaaa aataggaaaa gttggccggg 46620cgcagtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacaag 46680gtcaggagat cgagaccacc ctggctaaca cggtgaaacc ccgtctctac taaaaatact 46740aaaaattagc cgggcgcggt ggcaggcgcc tgtaatccca gctactcggg aggctgaggc 46800aggagaatgg cgtgaacctg ggaggcggag cttgcagtga gccgagatag caccactgca 46860gtctggcctg ggcgaaagag caagactcgg tctctaaaaa aaaaaaaaaa aaaaaaattg 46920gaaaagttat ttactattag cagcaattgt cataaagtaa tgaacattta ttgcatgatt 46980acaatgagat aaattgtatc ctgtttttat aagcatatta agttttcttt tttaaaaaaa 47040tgtatgtatt tatttatttt aagagatagg gtcttgctct gttgcccaga ctggagtgcc 47100atggtatgat catagctcaa tgcagcctca aattcccagg ttcaagcaat cttcttgcct 47160cagtctctcg agtagctagg actacaggca tgtgccaaca tgcctggcta gttttcttat 47220ttttaaatgt atttttgtag agacaggatc ttgctgtgtc gcccaggctg tcctcaaact 47280cctggcctca agcgatcctc tgccttggcc tcccaaaggg ctgagatgat aggcatctac 47340ctctgcattt ggcccacatt aaattttcta gtcatcatgg gaaccaaaat aaacaatata 47400aaacactcac attccttgag cacttactat atgcagggcc ctgtaataga ttattgtgtg 47460tatcagctca ttccattctc acacaaccta tgaggttgat gctattttct accttttata 47520tatgaggaaa ctgaggctca gagaaggaaa ctgccttgcc caaggtcaag gccacgtctg 47580atccccaaat cctttcaact cctctgcact actatttttt agtgcagata ttgccagttt 47640tctaagcaga agcatgattt agcagccctg agtagacttc tcatttcaga accaaagtgt 47700tggacattgt tggataatat gaaaaacaaa tgacacacaa acctatttga tactgttttt 47760aattttctct tcatttgatt ttcctgatga catgattaat cttttttgcc tctaccctgt 47820atgtgaaatg taggtctttg cagatgtctc agagagtgtt aatagttgct gctggttttg 47880ttttctctcc ccggggattc ccatccctgg gtgcaagtga aattaaactt gtgcctcttt 47940gccgctggcc gtggtgctga aaacatcccg ggcagcgcta gggttgccct tgttagcatg 48000ccatccctgc taagagtctt aggctgatca gcgagtggag agatcttttc caggcttcat 48060tttggttaga actgtgtgtt gaagatttta aagcccatgt ctgggaactg gagactgttt 48120ggattgtttg aagttgaaat agtcatgaat aattcctact tgagatgggc ttatgagggc 48180gtggactagc atgcaatggt tggcctttac taaactgtgg ccattggttg ggacttgggt 48240gaggtgtaac ccatttggtc taatccatat ggttagggcc ccaagtgcac ctgcattcta 48300tttttttttt tttttaaata aaggcaaacc catctatctt ctaaccagga tagctcctga 48360gtggtctttg gggaccacca gcttaaaagc atagactgtg ggctgggcac agtggctcat 48420acctgtaatc ccagcacttt gaaaggccaa ggtgagagga tcgcttgagc ccaggagttc 48480aagaccagcc taggcaacat ggtgagaccc tcatctctac aaaaatgtta aaagttagcc 48540aggtgtgttg gcatgcacct atagtcccag ctactcagga ggctgaagtg ggtggatcgc 48600ttgagcctgg gaggtcaagg ctacagtgag ctgtgatcgt gccactgtat ttcaccctgg 48660gcaacagagc aagaccctaa ctcaaacaaa caaacaaaaa aaggcataga ctgtggagtt 48720gggcagacct gggtgtgagc cccagctctg ccagtacctc ctatgtgacc ttgaaaattt 48780gtttaatctc tctgagcctg gattttcttg tgtggaaaat gaggcttacc acagaaccca 48840ccttgtagaa atgttgcaag gaattaactg aaacaaagtg cttaccacgg tatctgccca 48900aagaagcagt tggaaacaag gcagctgtaa ttatggtcgc tgtgcttgtt aatggcccca 48960taatagttga tcatattgca gagtgaaatt ggggtatgtg tttaatggac caaggaatat 49020gtcttaaacc catatatcta gggttctggt accctctact ctttttcctg gtgattgtga 49080tgagcatgga acttacatga aaatgaggtc tgtttggctt cttcacacaa gctcaatgac 49140ctggctaact gctacaagta tctgtttcct tagaacccac ccatcagcag tccccatagt 49200ggagacaagg tcacaaagag ttgacaaacc tgatttgatt tccgcaccaa ccacaggagg 49260cttgaaatga gatgagggtg aagggcacca cagagggatg caaggattac ttggacactg 49320caaggtcttg ctaagggatg ggaaccatca gccacgccca ctttgagaat tttccttcat 49380gttctgaatc tgaagagcaa ggtcctgttc tcagatgcaa gccctccttc ttccctacgc 49440agagtcaaac ttggtctttt ccagggtcac atacagcctc tctctggggc ctctgcaggt 49500cctgatcaat ttcattgtgt atagagctct gtgtctcctc acctgcctgc agggctgtct 49560gctatcctga cttccgagag ccatttcgga agccagcttt tcctcccatc agggatgctt 49620ctcttctttc agcccccgcc ccgctttggc ctcctaggat ggctgatttt tctggatccc 49680gctgacacag gtgctttctc tccgagccaa tcagggagca gaaaggctca gctcagctaa 49740cagaggcatt gctcaccgca gctgtgagtt agaactcagg ctttctaaat cgggaggatc 49800aggcatgact tgaggttggg ctgagaaagc ctcgcctgcc ccccagctcg actacccagt 49860gaaacctttg gcttctgcct cgggcgaggc atctcttacc atgccaagaa ctcagcagcc 49920catctttctt tcatctgggc accaagtaca tcattgcata tttcaggggg tttcattgtg 49980tccttaacat gctcatggag acttggcttg agatgaagtc ggggtttcta ggcagcagga 50040cccatgtccc cttccttcat ttcctccacc ggtgattttt gttttgtttt gttttgtttt 50100gttttgtttt gttttgtttt tgagacggag tctcgttctg ttgtccaggc tggagtgcag 50160tggcgttatc tcggctcact gcaaactctg cttcccgggt tcaggtgatt ctcctgcctc 50220agcctcccaa gtagctgaga ttacaggcgt ctgccactat gcccagctaa tttttgtatt 50280tttagtagag acggggtttc accatgttgg ccaggctggt ctcgaactcc tgacctctgg 50340tgatccaccc gcctcggcct cccaaagtgc tgggattaca ggtgtgagcc accgcaccag 50400gcccttccac tggtgttttt tgagcatcta ctatatagag aatgctctcc tgggcacaga 50460ggatgaagca gtgaacaaag tagacaaaaa atccccacgt gcatagagtg tgcagtctcg 50520tgggagagac agggaacaag ataaagaagg aaaaaaatag cagatgcttg actggggacg 50580gggactaaag aaagaaaaaa ataagcaggc taagggggtt gatggatgtg acctttgagt 50640aaaggcctaa aggaagtgag ggagggagtc atgtggatgt ctggggaaag actattccag 50700gagaatgaac agcaggtaca aaggcccctg ggtacaaatg tgcctgggga gtttggggaa 50760taaaagggag gccggcgttg ctgtagctga gtgactaagg gagagaatag aggagatgag 50820gggagggagg taatgggagc aggtcatgca ccttgctggt gctggaagga ctttgttttt 50880gcttttgagt gagatgggat ccatgggaag gctttgaata cttccacatg cattaggctg 50940aaattttctt ttctgctttt gtcgcattcc aacattgctt ttatttcatc aaaatcttcg 51000gtttcttctc aggctcttta cccaagtggg agcagaaggc tggtacccag ggctgttcag 51060ttctccccct ggggtcagaa cgtggaggag aaagcttgga ggagaaacag gaacccccac 51120ctctttctgg atgactcaaa accgcaatta cctgagctcc tcctcctatc cctgaaatag 51180aggcacttag cacttcctaa acttcccggt gcacacaaat cccctggcga tctttttaaa 51240tgcaggttct gactcagcag gtggatgcaa ggtctaaggc tgcattccta accggtgctg 51300gttctgggac cacactttga gtagcaaggg tctgaggtca ttgttgcaga tgtccatctg 51360gggcatgtct gtggacactt gcgggggtgc gggtgagcag agggaggggg gatgatgttg 51420gaaaagcagt gtgagtatct gtgtttgata agaagtaaga aaatgaagca aggtgggaga 51480gtagaacctc tttatttttg cctacgtgct aaggttttat tgccataccc agagagccct 51540gggtctgaaa tccaggcaac actggccagt tgaaaccctg atattgcagc ccataaaagt 51600gctgcatgct gcatggtgga cttctgggac tcttcctgga accttcagtg ccagagccgg 51660tccaaaggaa gtcacatccc tgccattgag gggcaggaga ccagggaacc ggaggagtgg 51720gatggcagaa gcgcgtgtaa ggaggctgag ttggcaggga gagaaagcga agtcagcttc 51780aaatcatagc gagaggagac cagggaaggg cttggcgttg ctgctctgtg tacaaatatt 51840gtctcttatt ttccaggctg cagggtgagg cagagtggag tatttgtgca acacagccca 51900gctttgttct ctgggctcct aatgcctgtc agctcagagg cagaaagcca atcagagatg 51960atcgtcggca aggccggctt ttgttggctc cccaaattgc cctgagtctc ggattttgct 52020tttcagagtg tgctttcagc tggaggcaaa ggctgaagct ggtgacaaaa ggaagcctgg 52080ttttcctggc tttccgagac ttttactgag ggggtttcta tttcagactc cgttttccca 52140cctggaaagc aggttccact ctccctccgg cctggaaggg atggttttat ggtgcttcca 52200aaatgccaaa cctaactcca gggcagaaga ggagactgaa accaattaat tttccaaagg 52260ttagagctac gaggagggga gaggtttagc atggtcaagt tccccaagac atactaattg 52320atctctctac agaatgcggg atttcagtgc ccccagggga cactcagcaa tgtttagaga 52380ccacttgagg ttgtcatcac tggacaggag gggctgctac tggcatctag cacacacagg 52440ccagggatac tgttgaacat gctgcagtgc ccagacagcc ccaccaagga gaatgatcca 52500cccctaaacc tagtgctgag gttgggaaat cctgctccgg agtaaccaac accctatggc 52560tttttcactc aagcagccgc ttctccagcg cttacacctc ctcagagatt gccagatcca 52620tatgcagagc ctgttggcgt gggacacttc tgaggggtgt ggcagggaga cagcggacat 52680tcccatttac cagctgatca gcaggttagg agctaatatg aaatgaacaa gatagaccct 52740ccccacctgc cctgcagatc ctctggtggg acactaggga gggaggcctc ctaaacccaa 52800atgacagttc ccaggatgca gggaggagtt tacctatgca aactggagag aatgcaaatg 52860gggcatctag agatacttac tggacgaccc ctcccctgcc tcgggtcttg gaagaacaga 52920ttctcagagg tctgccctga tcactgtaat ttttttttta ttgaggtaaa attaatataa 52980cacaattaac cattttaaag tgacatttag ggctgggcac agtggctcat gcctgtaatc 53040cccgcacttt gggaggctga ggaagaaagg tcgcccagga gttcaagacc accctgggca 53100acaaagtaag actctgtctc ttacaaaaaa aaaattaggc acacatggtg ttgtgcacct 53160gtagtcccag ctactcagga ggctgaggca ggaggatcgt ttgagcctag gaattcaagg 53220ctgcggtgag ctatgatcat gccactgcac tccagcctgg gtgacagagc aaaattgtgt 53280ttctttaaaa aaataaaagt aaaaataaat aagaaaagaa aggagagggg aggggagagg 53340cgtttagtac actcacaatg ttgtgtaact gtcaccttca tctagttcta aaacattaag 53400cagccactcc catttccctt gccattcccc aggaacaaca aatctgctgt ctgtctctgg 53460atttgcctgt tcgggatatt tcatatacat ggaatcatac aatatggggt attttatgtc 53520tgcttctttc gcttggcata atgttttcaa ggttcattcc tgttctatca tgtatcagta 53580cttcattcct tttttttttt tttttttgaa acggagtttt gcttttgttg cccaggctgg 53640agtgcaatgg cacaatcttg gctcactgca acctccgcct cccgggttca agcaatcctc 53700ctgcctcagc ctcctgagta gctgggatta caggcatgcg ccaccacacc cagctaattt 53760tgtacttttt ttagtagaga tggggtttct ccatgttggt catgctggtc ttgaactccc 53820aacctcaggt gatctgcctg cctcggcctt ccaaagtgct gggattacag gcgtgagcca 53880ctgcacccgg cctacttcat tcctttttat ggctgaatac tattccattc tatgagtaga 53940ccacattttg tttatccatt cacccactgg tgaaatttag gttgtttcca tcttttggct 54000gttgtgaata gtgctgctgt gaatatttgt gtatgagtgt tcgttggaat acctgtctta 54060cgatcctttt gtgtttatac cttggagtgg agttactgtg tgtcacatgg taactctgtg 54120attaactttt tgaggaacca aggaatggtt ttctatggca gttgcactgg tgtttttttg 54180ttgttgttgt ttttgttgtt gttgttttga gacagggtct cactcccatt gcccaggctg 54240gagtgcagtg gtgcagtcat ggttcactgc agcctcaacc tcctggggct caagcaatcc 54300tctctcctca gcctcccaag tagctggcac tacaggcctg cgccactatg cccggctaat 54360ttttcatatt ttttgtagag atagagtctc agtttgttgc ctaggctggt ctcggactcc 54420tgtgctcaag taatcctcct acctcggcct cccaaagtgc tgggattaca ggcatgagcc 54480accgcatctg gccagctaca ccattttata ttcccaccag catgagggtt tcaatttctt 54540cacatcttca ccaacacttg ttttctgttt gtttgtttgt ttttaatagc tatcctagtg 54600gatgtgaagc agtatcccgt tggggtttga tttgcacttc cctgatcact aataccctca 54660tgtacatatt ggccatttga ctgtcttctt tggagaaatg tctattccag cctcctgtcc 54720atttttcaat tggattatct ttttgttgtt gtgttgtaaa tgttctctct ttatttttta 54780tttttttgag acagagtctc gctctgtcgc ccaggctgga gtgcagtggc acgatcttgg 54840ctcactgcaa gctccgcctc ccaggttcac gccattctcc tgcctcagcc tcccgagtag 54900ctgggactac agatgcccgc taccacgccc ggctaatttt ttgtattttt ttagtagaga 54960tagggtttca ccgtgttagc caggatggtc tcgatctcct gacctcatga tccacccgcc 55020ttggcctccc aaagttctgg gattacaggc gtgagccacc acacctggcc gtaaatgttc 55080tttatatagt actagaccct tatcagatac atgatttgca aatagcttct cctattctgt 55140tacttgcctt ttaactttct tgataacgtc ctttgatgca caaaaggttt aaattttgat 55200aaagcccagc atatctgttt tttcttctgt ggatcatgca ttaggtgtca aatctgatca 55260taatgtttta tttatttatt tacttattta tttattattt tatttatttt tgagatggag 55320tcttgctctg ttgcccaggc tagagtgcag tggcatgatc tcggctcact gcaacctcca 55380cctcccaggt tcaagcgatt ctcctgcccc ggcctcccaa gtagctggga ctacaggtgt 55440gtaccaccac gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg 55500ccaggctggt ctcaaagtcc tgaccgcaag tgatccaccc accgcagcct ctatctattt 55560ttaatttatc tctttttttt tttttttttt tgagacaggg cctccttctg tcacccaggc 55620tggagtgcag tggtatagtc attgtacact gcagcctcta cctcctcggc tcaagcaatt 55680ctctcgcctc agcctcccaa gtacctggga ccacaggtgc ctgccatcat gctggccctg 55740ccaccatatt tgaaattgca gccctgaccc cttccactgt ctatagtctt caccatctta 55800ctacataaca tagcatatat gatgtactgt ataacatggt atatgcagtg tactgtatag 55860catagtatac atgatgtagt catctcattt atttgcttct cctctgggaa gcaggaggaa 55920gcttctcctc ttgtctgctt tgctctcaac tgtgtcccta gcccagaaca gagtctggca 55980cacagcaggt actgaatgaa tatgtgttca gtgaatattg tgggtgagat agaaggtgaa 56040tatccacatt tccctttaga agtcacctga tctgggtttg agatctgcag ggatctactc 56100cagacaggag aacgaataat tccacctgtg ctgatgagtt ggaaggatct agagggcttg 56160agatctttcc actggggtca gtgggggtgg gtgcacctcc aacacccttc ttttctttga 56220acaagatttt tccttaattc cccaatactc cctttgaata tatgatttta gccaccatca 56280tagcgaattg catcgtcctc gcactggagc agcatctgcc tgatgatgac aagaccccga 56340tgtctgaacg gctggtgagt gatgtctttt ctcagggtct tctccttggc tttagcagga 56400cattaatttt tgggggagtg gagcagggca cagaggaggc tctcagtcct ggagcccaga 56460gccagatcat gggaagccta aatttccttt tcattttttc ttgaaccaga gtctcgctct 56520gtcacccagg ctggagtgca gtggttcagt catagctcac tgcagcctcc acctcctggg 56580ctcaagccat cctcccactg cagcctcctg agtagcaggg actacaggtg ccaccatgcc 56640cagttaattt tcttattttt atcttttttt gtagagatgg ggatctcact aggttgctta 56700ggctggtctc aaactgccca ctttggcatc tgacataatt tcaggcagta tactcaaatg 56760aacattgtta atgttaataa ttatgtcttg gccagacact gtagctcatg cctgtaatcc 56820cagcagtttg ggaggccaag gcaggtagat cacttgaggt caagagttcg agaccatcct 56880gaccaacatg gtgaaagccc gtctctacta aaaaaataca aaattagctg gatatggtgg 56940tgcacacctg taatcccagc tacttgggag gctgaggcag gagaatcgct tgaacccggg 57000aggcagaggt tgcagtaagc caagatcgca ccattgcact ccagtctggg caacaggagt 57060gaaactccat cttggtgggg gggaggcgaa aaaaaagaaa caagaatatt acaaaggata 57120cagatgaaga gatgcaaagg gtgagatata ggagaagggt gtggctggca gcttctaggt 57180agcttcagga gggggactgg tcaccagaaa gaccaaggca tgattcgagg gttgcgactt 57240tcagccccac cccccaacct ctgggagggc agaggggctg aaaatcaagt tgatcaccaa 57300cggtcaatga tttaaatcca aacctctaat catgccttgg ttttcccggt gaccaacccc 57360catcctgaag ctacctagaa gctgccagcc atcagtcaat ccttagcctg caaaaagaca 57420tccctttgga gatcccaagg gttttaggag ctgtacacca ggaaacagtg tcaaagacca 57480aacatacatt tcacaatgtc acagtcttct aaaaactata actagcctag caaacctatg 57540atttctagat ctttgcattt tcacttaaaa taaagctaaa taaaaagcgt ccattgaaag 57600actggtaagc aagtagaagt accagtggca agctaatgtg gaaaaaaaaa atcattcagg 57660cagagtgaaa atgattgtag ctcgagaaac gttgctgtaa cagatgggaa aacattcaca 57720ttggggctct gatggagaag agcttgtagc ttaatttcaa atatgataga ttagcagctg 57780gaagccagaa ccagccggag gttctgcaga ggaactggag gtgaggatac tggccactta 57840tcagccagta cagaagtcct attccaaacc tttaacaatc tacatgccag ctgagaacca 57900tcctaagggg tcagatttag gagtgaggtc aatgcacaag ctctagcctc aaataccttg 57960aacgctgcat gtgacaagta aattctctaa accaatgctt tccattagaa ctttctgcag 58020tcacagaaat gatctccatc tgccctgtcc aataggattg tcacttgaaa tgtagccagt 58080gtgactgcag aactgtgttt tttattttat tgcatttaaa ttaattttaa ttgaaatagc 58140cacatgtggc ctgtgactgt cgtattgaat aagacaggtg caaacaaata attctgttta 58200gctgagtgat atgtgaggtt ggcccaaaag gaatgaagga ggaaggtgcc ttctctaggc 58260attggctttg ctcgcaaaag gctttggaca agagaactct gcaagaggca gtgaggggtg 58320gtgagtgcag gagggtcagg ggaagtgaga gggtgatagg tactgatttc taggtgggct 58380ggttccctga tcttgtcaac atctgcccag cccaagacgc tgaccttgcc ttctctccct 58440tccaggatga cacagaacca tacttcattg gaattttttg tttcgaggct ggaattaaaa 58500tcattgccct tgggtttgcc ttccacaaag gctcctactt gaggaatggc tggaatgtca 58560tggactttgt ggtggtgcta acggggtaag tggcgcgtgc tatacgcttt ggatttaact 58620agctgaagga ttacgaggct tttggttggt gtggtccggg ccaggctcag gaaggctgag 58680cccttgtgtt ctccctcccc ttgttatgcg cctgcctcct ttctgccaac accccacctc 58740catgtctcag ctgtatatta cagcagatgc tttctgttac aattaaaata atagctcatt 58800attgttggct gcttccagag tgctttatgc ccattctcta atttaatcct tgcaacaacc 58860cactgaatta ggaaatatta atattcccat ctgaccactg aggaatcaga aactcagagt 58920gtaacttgct taaggccacc cagcaagtaa gtgatggaac tgggagatga acagaagatt 58980atgcattcca gaactcaagg ttttaagtgt tgtacgtgca tgggtctctt gatttgcttg 59040aggatatctt gcttttattt caacttggtg aatgtttttt gagaatgtct gggtgcaagg 59100gattgtgatt atgacaaagg agaaaagcaa gctaaataag gtacagttac tgtcttcaag 59160gagttttcag atccatatat gatgaactgt ggttgaaatg tgtatatgct ttcctctaag 59220caccctgtat gaggtagcac ttgctggtat aacaaaagat ccaaagctag gaaatgactt 59280aaacacggca gaagtttatt tgtcactcat agaaaattca aaattgagct gggtgtggtg 59340gtgcatgcct gtaatctcag cactttggga ggctgaggtg ggaggatcac ttgagctcag 59400gagttcaaga ccagcttggg caacacagtg agaccacccc cccatctgta aaacataaaa 59460taaaataaaa attaaccagg catggtggta catgcctggg agaattgctt gagctcagga 59520gttggagggc acagtgagct atgatcatcc aaccgtgctc cagcctgggc aacagagcaa 59580gaccccatct cgaaaaaaaa aagtccaaaa taattgttcc tagttgacag gctcatctcc 59640tccaatgact gacggaccct gacccttgcc atattgtggc tcttcattgt cagcccacat 59700catccaataa ctccatgctt gtctgtatca aaccaggaag gagaagtgag catagaaggt 59760gatacttgga aaggtttatg agtttggaag gggtgtgacc catacctgtt ccattcatat 59820cctattggct agaactcggt cacatgacca cacatcactg caagggaagc tgggaagtat 59880cagattgtgc ttagaagaaa agggaaatgg atttggagaa tgacctacta gtctgtcagg 59940gaccttaaaa acttttatta gattccagta gggacattag tatctggtac caatggctgg 60000ttcctcctct tcccactctc tactctcctc tcagctaagt ctgggctctt ctattctaag 60060acccttcttc actggacacc tttttcatag taatcattta caggatcata gctttccatg 60120ttttgttgct gctccaggtt ctgtctctct tggcggatgt gatgggttgc agcacccaca 60180ctgtgctggc cgggctctca caatgcagat ttgtttcaga

gcaatgttgc ctctcacaga 60240aggagctgtg gcctattggg ctgtttctgt agaggccttc agatgtcagc agtctgttgt 60300aaggactctg ggctagctct catgggcttg ggtgttcaca gagggatctt tgttggctgt 60360gctcacagtt cggtggcttg ggaccttggt gggttccaag ggcatattat ggtactgggc 60420acttttctct tagtctacta ggaaactcat ctagaaacag cctagtggct aactttttta 60480ttgtttaaaa aatgtaaagc tgggcagggt ggctcatgcc tgtatcccag cacattggga 60540ggccaaggtg ggaggattgc ttgggcccag gagtttgaga cgagcctgag caacatagca 60600agaccacatc tccacaaaat aaaaattaaa agtgtataaa gctgggtaca gtggcacatg 60660cctgtaaccc caattactca ggaggctgga gagagaggat tgcttgagcc taactagttt 60720gagaccagct tgggtaacct agcaagatcc catgcaaaac taagtagaga ataatagagc 60780aaacacctgt gtatacattc atttattcaa tgactattta ttgaacactt ctgtgtgcca 60840ggtcctgttc taggctctgg gacacagcag taaacaaaat agaaaaatcc cctgtcctca 60900tggagctgag agtctactga tggagatgga cacaattgat gaatgaatct agtgtgtcag 60960atggcggtga ggggtacaga ggaaaaataa agcaggggag ggatgggatg tgtggcaggc 61020aggggtgagg ggtgctggaa gccagggaag acttcactgg gcatgtgaca tctgaatgaa 61080aacctaaggg aggtgagtga gtgagccatg aggagagctg gaacagagtg tcaggcaaag 61140ggaacagcca gtgcaaaggc tctgaggctg gactgtatct gacatgtttg atcaacagta 61200agaagaccca catggctaga gaaggtgacc agaagaatgg ggagaattgg ggatagagaa 61260gtaatggagt aacctgctat caaaacacaa cctttctctt tttttttttt tttttttttt 61320tgacaagagt ctccctctgt cacccaggct ggagtgcagt ggtacaatct cagctcactg 61380cagcctctgc ctcccagttt caagtgattc tcctgcctca gcctcccaag tagcttggat 61440tacaggcgtg taccacaaca tctagctaat ttttgtattt ttagtagaga cgggtttacg 61500ccatgttggc caggctggtc ttgaactcct gacctcaagt gatccacctg gcatggcctc 61560ccaaagtgct gggattacag gcgtaagcca ctgtgcccag caaaacaaaa cctttctaac 61620ctttctaatc cctgttttct ccctccctag acccattcct ttctctcccc catccagggg 61680cactttcctg aattttatgt ttattatttg catttatgta ttcacacttt ggctgcctaa 61740gtatataaga aatatatgct acctattttt acacttcaaa atatttttta aatagcatca 61800gagtgagaat agtttacact ttgactacat gcatagataa gaaatatgtg ggctgggaat 61860ggtggctcac acctgtaatc ctagcaattt tggaggcaaa gatggaagga ttactttagg 61920ccagaagttt gagaccagcc tggccaatgt agtgaaaccc tgtctctaca aaatgaaata 61980aaatgtaata aaatattcag ctgggcatgg tggtgtgctc ctgtggtccc agctactcag 62040gaggccaagg cgggaggatc acttaagccc ataaggtcga cgctgtagtg agctatgact 62100gcactccagc ttgggcaaca gagcaagacc ctgtccctaa aaaatgtttt ttgttgttgt 62160tgttgttttt tgtttttttg tttttttaat aaaggccagg tgtgatggct cacacttgta 62220agcctagcac tttgagaggc cagggcagga agactgcttg agtccaggag tttaagacca 62280gcctgggcaa catggtgaaa ccccatctat aaaaaaaatg caaaaaatta gccaggcatg 62340atgacgcacg cctgtagtcc cagctactca ggaggctgag gtgggaggat cacgtgagcc 62400caggaggtcg aggctgcagt gatccgtgat tgcaccactg cactccaggc tgggcaacaa 62460agtaagacct tgtctcaaaa aaataaaata aaataaaaaa taaaaaaaag aaaagagaaa 62520gaaaaaaaga gatatgtggt actgtttttc aaacttcaca tttctctaac ctgacttttg 62580tgttcaacat gagataaatc tgattaataa aaatagtttc catgcatcca ttttcatgac 62640tgcatagtat tctgtggtag gagtatgctg ccgtgtattt atctatttgg attgtttcca 62700gctttgggct attttgaccc aaagtgtccc tgctttctcc caagtgagtt tctctagggc 62760acgtacccag gagtggaact gctgagttgt atactgtgtg catcctcagc cccactaggt 62820attgccaaat tgctctgcaa agtggttgtg ccaattcatg ctccctgggg gctggcttct 62880gctggctgag gctggcttga ccttgctggc aggaaggagc cttaaaaatc cctgtgtggt 62940tttttttgtt ttacttttat tttaagttta ggggtacaag tgcagatcta ttacatgggt 63000aaacttgtgt cttgggggtt tgttgtacag gttatttcat cacccacgta ttaagcctag 63060tacccattag ttatttttct tgatcatctt cctcctcccg ccctccaccc tccaaaaggc 63120cccagtgcgt gttgttcacc tctgtatgtc catgtgttat catcatttag cccccactta 63180gaacacgcag tatttggttt tctgtttctg cattagtttg ctaaggataa tggcctccag 63240ctccgtccgt gttcctgcaa aggacatgat cttgttcttt ttcttggctg catagtattc 63300catggtgtat atgtaccaca ttttctttat ccagtctatc attgatgggc ttttgcagcc 63360ctgttttttt ttttttttca taataacacg gttatgggaa cacttaggga agctcatata 63420ttattgagca gtgtgatggt taatattgag catcaacttg atcagcttga aggatgcaaa 63480gtcttgttcc tgggtgtgtc tgtgagggtg ttgccaaagg agattaacat ttgagccggt 63540gaactaggag aggcagactc acccccaatc tgtgtgggca ccatctaatc agctgccagt 63600gtggccagaa taaaagcagg cagaagaagt tggaaagagt agacttgctg agtcttctgg 63660ccttcatctt tgtcctgtgc tgaatgcttc ctgccctcta aaatcagatt ccaagttctt 63720cagcttttgg actcatggac ttacaccaat ggttagccag gagctctcag gcctttggcc 63780acagactgaa ggctgcactg tcagcttccc tacttttgag gtttgaggac tctgacggat 63840ccaccactgg cttccttgct cttcatcctt cagatgggct atcgtgggac tttaccttgt 63900gattgtgtga gtcaattctc cttataaact ccctttcata tatacatcta tcctgttagt 63960tttgtccctc tgaagaacct tgactaatac agacacctag tgggtcccaa taagtgatca 64020ttaaactgaa ggcagtcatt cagtaggtca gtttgtcact tgtgtttgta tctccctgct 64080tacaacaagg tggcctttct tctagtttcc tgtcatctga tggaagagat tctagactca 64140ttcctctaga ggagaaatac ttcatctaga acagataggt cctaagggtg agagctcatc 64200gttgggatga atgaacccac tgaaatttta tgcaagaaga aaattgtgta tatgtatatt 64260tttttttctg gtctgtagtt tttattagat tctcagggaa tcctgatcct atcatgaaga 64320ccttctattc tagattgggt tcctttcaca tccccttctc ctttcttgtt gaattctcca 64380tgcatttctt tcacttgctt ttcttgctct tatttctctg gtagtcagtt atcctttttg 64440tctggtggtt ctatctcctt caaatgaggc acattgctca aattttatta ctccaaattc 64500caaggtgctg tttagtgtcc tgttgggttg taagctagga acagggaggg gaaagtaaaa 64560cattctgcat gagctgggtg cagcgggcaa gcacctggaa ttccagctac tggaagctga 64620ggtgggagga ttccctgagc ccaagggttt aaggccagcc tgggcaacaa agtgagattt 64680tgtcttaaaa aaaaaaaaaa tcccagctgg gctctgtggc tcatacctgt aatcccagca 64740ctttgggagg cagaggcggg cagatcgctt gaagtcagga gttccagacc agcctggcca 64800acgtggtgaa accccatctg tactaaaaat acaaaaaaaa aaaaaaaaaa gcctggcatg 64860gtggtgtggt gtgcactggt aatcccagtt atttgggagg ctgaggcagc agaatcactt 64920gaatccagga ggcagaggtt gcagtgagct gagattgtgc cactgcactc catcctggat 64980gacagagtga gactctgtct caaaaaaaaa aaaaaaaaga aagaaaaaac acgcgcgcac 65040acacacacac atcatgcaga cctagccttc tgccaatgtc aatggtagag aaacacagta 65100gacacttaat tctatgtttc agagaggagg ggactcaaat atattaattt gacattgaga 65160cagtgatgac tttaatgagt actttctttc cttttttttt tttttttttt cgggacagag 65220tgcagtggtg ggattttggc tcactgtagc ctccacctcc tgggttccag cagttctcct 65280gcctcagcct cctgagtagc tgggactaca ggcatgcact gctgtgcctg gctaattttt 65340gtatttttag tagagacggg gtttcacact atcagccaga ctggtctcga actccggacc 65400tcaggtgatc tgcccacctc ggcctcccaa agtgctggga ttacaggcat gagccaccgt 65460gcccggccta atgagtactt tctgattaac ctgttgccct ctcagattcc tgaagcaaac 65520cacagcgtta aaacgtgatt cattttgtgt ggaccaccac ggtgtttacc ttcttcttgg 65580gtgaagtttg gtggaaaaga tcttaccccg gacatctgtt tgttctttgt aactcagagc 65640ctcagagaaa tcctaacttt ataatgttgt caaacccttg taaggcatgt ttttattgta 65700tttgtgttct gatcatgaaa ctgaaaatgt gtaagaggaa gatttcagaa gcttggctgt 65760atgtctgaga tgacagttct tttactgtca ttctcaaata tatataaata ttgaagagat 65820caaataacac aaatcgtgca tgttaagaaa agagactgtg aacctcacca gagaggggtg 65880agcacaattt tttttctttt ttattcacag ggttagcact gtccctttca cataataaat 65940gctcagtaaa ataaatggtt gttaagccgg aaaagggtaa cacttctgat aatgagtgtc 66000ctgggaaatt tactaagctg tttagaagat gggaccaaca cactgataga aatagtcaga 66060tagtccagaa gtctatggca gatgccctga acatcagatg agatataaga cagagaagct 66120ctgggtcttt gccagctctg acattttatg actctatgaa acggaaggtt cctttttaga 66180agggtctata aactgtctca ggctttgggc cattttgttg aagatcagag gcaaggaaaa 66240gacacaacta cacaggaacc atcagggaaa gatgttgttt tttggtcttg aagcatcatt 66300gaattttttt tttttttttt gagacggagt ttttctcttg ttgcccaggc tagagtgcaa 66360tggcatgatc tcggctcact gcaacctccg cctcccaggt tcaagtgatt ctcctgcctc 66420agccttctga gtagctggga ttacaggcat gtaccaccaa gcccgggtaa tttttttgta 66480tgtttagtag agacgaggtt tctccatgtt ggtcaggcta gtctccaagt cctgccctca 66540ggtggtccgc ccacctctgt ctcccaaagt gctgagatta caagcgtgag ccaccgcacc 66600gggccgcatc attggatttt aaggctccat ggattctggc aggtccagcc cttctgtttt 66660actcacaaac aagtggtttg tccaaagtca cacagagatg gtggcaagag atctagaata 66720agaaggtgtc ttcaagtcat ggagccagga accctggctt tttgggcaat ggaagtggta 66780taaatgttta atatcacccc tcaggttctg ccactagagc ccagctctct cttccttcct 66840cttgccccct gactagccta tggcctcttt ccagagaata agaaagggat cctcagagaa 66900taatcccagt tcctcgcttt ttattatata gttgaggaaa ccaagtctca gaggggtcag 66960tgtcttgacc atacacctct catgtcctct ctcctttttg attaattgaa taaatacatg 67020tagttgcttc ttacctcctt tctttcttca cccctgcccc atgcacctgc tcttagttgc 67080cttcacatgt aaacagcatt ccaacaacaa caacaaaaca caaccagcat tctaactcat 67140gagaccagca acagttccta taaataccag cagcatttta ttttaatgtc tctctgcagt 67200agtttctccc ctccatggat cagtcatcct tggtaccaaa aggattcccc actgtgacac 67260aaatgctttt tgtcattctc agtgagttat accattgaga gagcatcgat ctttttattg 67320ttcaaagctt ttggttgtca tgatatttgc tggaccatgt ttcaccagga accacatcac 67380ttcctagcag caggagctat tttcttccat cttctaacaa caccagcagt gacagtgata 67440ataatgatgt tagctgccat ggtcgttatt cttatcattt attgagtact tactatgtgc 67500cagggactac attaagagtt ttatgtgtat tatcacattg agcctcgcta gcctttgtac 67560agatgaatct gaggctcaga gaggttaagc tgctcacaag ggagtcacac agctggtaag 67620gggtggatca ggatctcagc ctctctgcta ggacacttct ctaaacctag aataatactg 67680ggcctgtgtt aagttcagca aagagctgta ttcaacccag tgtccttagg aatgtaatgc 67740ctgttattaa caacagtggc aacattgata agctgaaact tatgaggtgc ttacaatatg 67800atatactata tattatatac atacataggc acccacctat aatctcagca ctttaggagg 67860ccaagtcagg aggatcactt gagcccagga gttcgagacc agcctgagca gcatagcaag 67920atcctgtctc tgtaaaaagt ttattttttc agttggccag gtatgttggt acatgcctat 67980agtcccagct aatgaggagg ctgaggcagg aggattgctt gagcccagga atttgaggct 68040gcagtgaact atgatcacac cactgcactc cagcctgggt gacagagcaa gactgtctct 68100aaaaataaaa ataaaaataa aattatttca actctcaagg ttaaataaat actattatta 68160ttcccattta cagatggagc aactgaggct caaagacatt aaatgcttac tgtcttagtc 68220tgttttctgt tgcttatagc agaacacctg aaactgagta atttataaag aaaaagcaat 68280ttatttctta cagttatgga gactggaaag tttaagatca aggctgcatg agctataatg 68340cacacacact attgcactcc aggctgggtg acagggtgag accccgtgtc aataaataat 68400aatataaaat aaataaaaca aatttcaaca tgagttttgg aaggtttgaa atattcaagc 68460cagagcatct gtctcataag tggtggaccc aggatttgaa ctaaggcaga tctggatcta 68520gaacccattt tcttgaatcc tacgctattt ctctaaggtc aagtttgcca aggaaaataa 68580acttgagaat ttgaatagag ctctctgaca tgggaagtca gggtgatcct tccttcccct 68640ccctgatctt gggttccact atggctgggg gaaaacagga gcagaagaga tttcaagaaa 68700tgagagattg gcctagcgcc atggttaaga cctggacttc agagtcagag gaagctcctc 68760cctctatgac agtgagaatg tgggttgaac tcactgaacc tcagttttct cacctggaaa 68820aagggagtaa aactagtgcc tagctcctag ggtttgcatc acacacgaaa gttggtgaac 68880tgaaggaaaa aaacttaaat tcttgtgggg gagcatgtga tagatgctac aaattctcca 68940tgccttattt acctagctta cgtctaagtt cacctgcagc ttcctcttgg tacactccca 69000tctctctaca tctctgttgg agggcagtct ctggcatcac agagtttgct gagccagatg 69060cttaacaacc tcggtagcat ccctcaacca gtgagctagg gagtcagtgt ataaataccc 69120tggcttcccc attgctcagt gggaaaacac tgaaatatgt tatacagcat catagaggtg 69180cctcagtaaa attgaatcct agttgttcac ataaaaccca ttcactagtg taccctttac 69240caatctctct cttcctcatt cctcacttgt aattccttgc attacctccc aaattaacca 69300ttggacccta gtttttgcct tggggtctac tcggcgctaa ctcaaggagc ggaagttgga 69360agcttagcgg gttacaggtt tcagcaccct ggacagctcc cagcacaccg tattgtgcta 69420aaatgttctc ttccctccct ctgcctccag ctggggtgga gagggactga gtaaaggcca 69480gatggccagg tgaccttgtt ccatactgag cttcttggcc attttccctg tggggctgga 69540gaagaccttg ccatccatct ctccgcaggt ttgggggccg actgaggtct tgttttctcg 69600aattgctatg acaaatgcca gcctgcctcc aaggggcatc tgtcccactg cctctacagt 69660ttgcatgcct aatgactcct ctcctctcac cagggcaggg aggtggctgc ctggtgggcc 69720gcttgaagcc gggagaccaa gatcatgcca ctggactcgc aacaaaccga gactcttttt 69780tttttttttt tttcctcgag acagggtctt gctctgttgc ccaggctgga gtgcagtggc 69840gcgatcttgg ctcactgcag cctccgcctc ccaggttcaa gcactcccac ctcagcctcc 69900caagtagctg ggattacagg cgcacaccac catgcctggc taatttttgc atttttagta 69960gagagggggt ttcaccatgt tggccaggct gatctcgaac ttctcccctc aggtgatcca 70020ctcgccttgg cctctcaaag tgctgggatt gcagctgtga gccaccatgc ctggccaaca 70080gaataggact ctgtctcaaa aaataatttt ttttaaacat tgctttgcaa cccagctgct 70140tcttgtgcag gcatctctaa atgaggacag ccagtctaca tagacacgta aggaagcata 70200gtggttaaga cctggtcttt ggggttagag tggattccca acctgactcc actgtttcca 70260agctgtgtga ccttgggcaa gttactgtac ctccctgaat cttccatttc ttcatctgga 70320aaatgagagt agtagcatcc cctgacttgg tggggcatgg tggctgatgc ttgtaatcca 70380aacactttgg gaagccaagg tgggtgaatc gcttaaactt gggagttcaa ggccattctg 70440ggcaacatgg tgaaactcca tctctacaaa aacaaaacaa agcaaaaatt atctgggtgt 70500gatagtgtgt gcctgtaatt ccagctactc aggaggctga ggtgggagaa tcacttgagc 70560ccaggaggtc aagtctgcag tgagccgtgc ttgcaccact gcagtccaac agagcgagac 70620cttgtctcaa acaaacaaaa caaaacacaa aacaacaaca aaatactacc accttatgga 70680gttgttttca aggttcaatg agttaatgtc tgacccatgc tgggctgggt ttatggatgt 70740tacttgccca gggacagtct gaagaaagag aaagtgatat agtccattgg gcctcagctt 70800cctcatctgt ggaatgggaa taataattgc acctacctca aaaggtaaaa gtcagtgaga 70860tacatataag gcattcagaa caaaaactgg cacagaataa gtgctcaatt atattagcta 70920ttgtaagact aataactatc attataatga tgataataat tattactact tccccaggcc 70980cagttccata gaccagttag ttaactgtag ggaacgtttg ctattattag ttgggttccc 71040aatatctgac ctccctttcc aatttaggga gaatcctccc ctttctataa agtactgctg 71100gtctatggga tcccaccctc actaataagt tgaaggtgaa agggattcat tgtcacccca 71160tcacctggta gtcagggcat gtgatttaaa caaccagggc caggcgcagt ggctcacgcc 71220tgtaatccca gcactttggg acgccaaggc aggaggatag cttgagccaa gcccaggagt 71280ttgagaccag actgggcaac atagtgagac ccctatctct taaaaatttt ttaattagct 71340gggggtggta gcacaggctt gtagtccccg ctactcagga ggctgaggca ggaggattgc 71400ttgagcccag gaggtcaagg ctgcagtgag ccgtgatagt gccactacac tccagcccag 71460cctgggcaac agggcaagat cctgtctcaa aaaacaaact aataaaaaac tcaaccagtc 71520acgttttcct acccaggaat ttgaaaatgg accaagtgat ccaaacatga tggtttggac 71580tctttcatgg cctcctgcta caggagaagg tcaggctggc tacattgttc ctgctgattt 71640cccaaatccc ctcttctggc cccctgttga ttatctgagt ttcctaaaaa tcccttttat 71700gcctaagata gccggtcagt gtttggtttt gcaatcaaga acccagactg ggccaggcac 71760ggtggcccac gcctgtaatc ccagcacttt gggaggccga ggcgggcaga tcatgagatc 71820aggagatcga gaccatcctg gctaacgtgg tgaaaccccg tctctactaa aaatacaaaa 71880caaaaaaaaa aaaattagcc aggcatgatg gcggtcacct gtagtcccag ctactgggga 71940ggctgaggca ggagaatggc gtgaacccgg gaggcggagc ttgcagtgag ctgagatggc 72000accactgcac tccagcctgg gcgacagaac gagactccgt caaaaaaaaa aaaagaaaaa 72060agaagaaccc agaacccaga ctgatcctga gacaaagatt tgagggcaac gaatcacgag 72120gtcaggaaat cgagaccatc ctggctaaca tggtgaaacc ccgtctttat taaaaataca 72180acaaattagc tgagcgtggt ggtgggcgcc tgtagtccca gctactcggg aggctgagga 72240aggagaatgg cgtgaacctg ggaggcggag cttgcaataa gccaagatcg caccactgca 72300ctccagcctg ggtgacagag caagactcca tctcaaaaaa aaaaaaaaaa aatttgagga 72360caagtggttt gtttggcaat accaggaaac aggggaacag gatagtcaga aaagaaagag 72420aaagctgggc atggtggctc actcctgtaa tctcagcact ttgggaggcc aaggcaggtg 72480gatcacctga ggtcaggagt ttgagaccag cctggccaac atggtgaaat cccgtctctg 72540ctaaaaatat aaaaattagt cgggtgtggt ggcgtgcacc tataatcaaa ataaaataaa 72600atcaggatat tttattttaa aactctgtct tagtgtaact catatttacc tcttctgtat 72660gctcctttgc atcagttata tattgccata atacggctgt gtaacaaaca atccccaaga 72720cccagtggct tataatgaca agcatttatt tagctcatga ttctgaaggg tggcagttta 72780ggctgggccc agttgggtgc tttatctggt ctcagttgag ctcattcatg catctttggt 72840cagctgcggg tcagctgggt ggctcttctg tttggctgtt agctggctgc agactggtcc 72900aggatgacct cggctggaat gactgtgctc cactccctat ggtctttcac cctccagcag 72960gctagcctga gctagttcac atggcagctt ttcatcctcc agcaggctag cctgagctag 73020ttcacgtggc agcaatggga ttctaagaga aagaggaagt gttcagcctt cttaagggct 73080agtcccagga atggcacaac atcgtgttgg ccactgttgt ccaaagcaag caatgaagct 73140ggtccagatt caaggaatgg ggcaacagag cccatctggt atttacctgg ggccactggg 73200gccccattcc tgttccctgg ggccttttgc cctgacttct gtgggccctc agagcatatt 73260ttcagattcc tttccatccc tgaccctcag caatcaatgt agatgacgtg tcattactgt 73320gtcacttgca cagagaaaag gaggaaaaaa tgtcagcaaa aactctgctg agagcagagg 73380gcccatcata cagcaagctg gaaagaaaag tgggaatgat tacacagcct cctcagatgc 73440ttccagcttt tatcaaatct cactgtgata tctgagttct gaaccctcac aggtggttgg 73500cgtgcaaggg aagagatttc ttgtctgcca tgctgacatg cacagacacg caacctggct 73560ccctctgtcc actggggctt tggattttgt ttgttgaaat gttacccact cctgatcaga 73620gctggatgga aacctggctc tgattccatt ggctcagggg ctcaggtggg ggcagaggcc 73680aggctggttg ggtgtctatg tggagacctt aactcttctc cctcccgccc caactctttt 73740tgtttctttt tttttttttt tttttttttg agatggggtt tcactcttgt tgcccaggct 73800ggagtgcagt ggcgtgatct tggctcactg caacttctgc ctcctgggtt caagcaattc 73860tcccacctca gcctcctgag tagctgggat tacaggagca cgccaccata cctggctaat 73920ttttgtattt ttagtagaga cagggtttcg ccatgttggc caggctggtc ttgaactcct 73980gacctcaggt gatccaccct cctcagcctc ccaaaatgct gggattagag gcgtgagcca 74040ccacacctgg cccttttctt ttcttagctg cctccacctc tcttcccttc tgcagtgtta 74100ggtttatgga aaccgaggcc ggcgtagaga tcaacttcag agagcatgaa ctgagcatct 74160gctgggtctt agatccttta catagcttat catcttcaaa ccttctcaca gttctgtgtg 74220gctagagcca ggatttggac acagctctgc cccactgtag aaccaggctt ccttctgtcc 74280actgtcaaat tttagaggga gaaaataggg aaagggacac cagccttctc cacgagcagc 74340ttctgcccac tcaccccagg gactttgcac atgctgtgtg cctgtgtctg agatatgctc 74400cctcctctgt atctgcttaa ttcttaccca gacatgatac ataaagtatt taacatccag 74460gtggcaggga caccagctaa cctgaaaaga ggttcccctg ttgtgccaca tgtgtactca 74520ttgtttgctg cattgtgggg gcagtccagg ggccttgaag aggggccaag gtgccaaagg 74580ggcactctca ggcctcaagg aagtacatgt ttactgatat gatactgtct cttcctccag 74640gaaggaagcc ttccctgatc tccccactgc atgcccacta tgataccagt ttaggtcccc 74700tctttatggc catctgtggc atcagtgtga atcctcttaa tgttgtctat ttggttaatc 74760atctgtctcc ttcctctggg gggtaaagac agaaccacag agcctcgtgt agaacttgag 74820aatggggttc agtaaaaatc tgttgaatgc ataaatgggt gattgagtga atgaatgaat 74880gagtgaatga atgagtgagt ggatgaatga atgagtgaat gaatgagtga gtgaatgaat 74940gaatgagtga attaatgaat gaattcatag ctgataatac aggcttcatg gcttttgtta 75000ggcttgccca gacattgcta ggggatggac agaaggaaga agagctatac ttaattccag 75060tcctgttgtt ctgtagcagg aggagaaaaa cagggactgc ccagcctgct ctgggtggat 75120tcaggagcag ctgaggttcc tctcttattt gcaaacaggg aattcaaaaa gccccaacct 75180cagaatcaca ctcgcctcag cagctgtacc agccaagggg acaatgtggg aagccttggg 75240caccaggaat gctgagtgct tcgaaaaagc gaaggctcag

ggaacaatcc ctgatttttc 75300attcccttgt cctttctgaa gaaacaggca aaggcaggcc aggcacggtg gctcacacct 75360gtaatcccaa cactttagga ggccgaggct ggtgaatcac ttgaggtcag gagttcaaga 75420ccagcgtagc caacatcatg aaatcccatc tctactaaaa atacaaaaat tagctgggtt 75480tggtggtgca tccctgtaat ctcagctact cgggaggctg aggcatgaga atcacctgaa 75540ctggggaggt ggaggttgca gtgagctgag tctgcgccac tgcactccag cctggatgac 75600agagtgagac tccatcttaa aacaaaacaa aacaaaaaca agtaaagcct tgtgtgtttt 75660taaattgtag gttcagcagc aaagctctgt aataaggagc tggaccctgc agtcagacag 75720tcatgggctt ctccagtgcc cagccgagtg acccgaggga gttatgataa acaccaacat 75780tcatccacaa tttgtaccta gtgctattct caatatcttg agtaaattat ctcatttaat 75840cctccaggca catctttctt ggtaggtgcc gtcattgtcc ccagtgtaca tctgggaaaa 75900tgaggacagg ctggcagagc acccttcctg ctcacctctg ctgctctgct gacctctggc 75960aagactgttg tctctctgag cctcagtttc cccatctgaa aattggggcc tgtattagcc 76020cgttctcaca ttgctataac gagatgcttg gctggggctg ggcgtgatgg cttatgcttg 76080taatcccagc actttgggag gctgagttgg gcagattggg agtgtgagac cagcttgggc 76140aatatagcaa gaccccatct cttctaaaaa aaaaaaaaaa ttagccaggc atggtgatat 76200gcacctgtaa ttccagctac ccaggaggct gaggcaggag aattgcttga acccaggagg 76260cagaggttgc agtgagccaa gattgcgcca ctgcactcca gcctgggaga cagagtgaga 76320ctccatctca aaaaacaaat tatttttaaa aaattaaaaa aaaaaatgcc tggctgggca 76380cagtggctca cacccataat cccagtactt tgggaggcca aggtgggaag attgcttgag 76440cccaggagtt ccagaccagc ctgggcaaca cagtgaaatc ctgtctctac taaaagtaca 76500aaaattagcc aggtgtggtg gcacgcgcct gtggtcccag ctactcagga gggtgaggtg 76560ggaggattgc ttaagcctgg gaggtcaagg ctgcagtgag caatgattat gccactgcac 76620tccagcctgg gcgacagagt gagaccttgt aaaaataata ataataataa taaataaata 76680aaaaccctga gactggggta atttataaag aaaagaggtt taattgactc acgattctgc 76740aggctctaca gaaagcatgg cagcatctgc tcagcttctg ggaaggcctc aggaaactta 76800caatcatggc agaaggtaaa gctggagcag gtgtcctcac atggccagaa caggaggaag 76860agagagagtg gggagatgct acacaccttt aaatgtccaa tctcacaaga actcactcac 76920gatctcgaga atagcaccaa ggcggaaatc tgcccccatg atccaattac cttccaccag 76980gccccacctc caacattggg gattacaatt cgccataaga tttggttgcg gacagacaca 77040gatccaaagt acattaaaag taatggcaaa aaccacaatt acttttgcac caacctaata 77100tctcaggggc tcattgtacc tatttcacag gacaaatgaa ggtatcagta ataacagtag 77160cctgtagtcc cagctattca ggaggccgag acaggaggat cacttgaacc caggaggtcg 77220aggctgcagt gagctatgat cacgccactg cactgcaccc tgggtgacag ggcgaaaact 77280tatctctaaa aataataata acaacaacaa tagtgaacac agatataaca tgtgtgtggc 77340caggctgtgc ccttagggct ttgcagggat tatttcattc actctcaatc tccccatttt 77400acagatgaga aaactgacgt tcagaaaagc tagaggactt gccccaagcc acacggctag 77460gaagtggtgg aattggggtt taaatgagga agcttgactt cagtgtcgaa gctcttaact 77520gccacactca atacatggag tagaggttgc tgattctgtg attatctgat tctggaaagt 77580aaagaccctg tttccagacg tttgctgctt gacttagttc ccaggggatg gccactggat 77640gatgcagtgt tgcccaggag aggttagcta gacacactgc aaccattcca ttgctaatac 77700ttatacttgc tcttgttctg ctgggtgcta tgcagggaag ggctgtctga gccctttgca 77760agaattctcc cattggtgcc tcccagagat tctgaggttg gggctttttg catcccttat 77820tagcagatga gacaccaaag cccaggtcaa taatctgacc tgcatccccc gcctaccagc 77880cagaccaagg tcacttcccc acaatgcagg ccctgatcca aggctctggg tgcaaaccag 77940tttccatgtc cctgggggtc catcttcttc agctgacttt tttttttttt tttttttttt 78000gagacagcgt cttgctttgt tgccgaggct ggagtgcagt ggtgtgatca tggcttattg 78060cagccttgac ctcccaggct caagcaatcc tcccacgtca gcctcctgag tagctaggac 78120tatgggcaca cgccatgatg cctgggtaat tttttttttt ttttttttga gacagagtct 78180cgcactgtag cccaggctgg agtgcagtgg cgcaatctcg gctcactgca agccccatct 78240cccaggttca tgccattctc ctgcctcagc ctctcgagta gctgggatta caggtgcctg 78300ctacctcgcc tggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc 78360aggatggtct ccatctcctg acttcgtgat ccgcccacct cagcctccca aagcgctggg 78420attacaggca tgagccagat gcctggctaa tttttaagtt tttttataaa ggcggggtct 78480tgctatgttg cccaagctgg tctcaaactc ctggcctcaa aaagtcttcc tgcctcagcc 78540tcccaaagtg ctaggattac agacatgagc cactgcaccc agcctgactt tttttctaac 78600tgaaaaatta attatatata ttcatggagt acaatgggat gttctgatat atgtttacat 78660ttttgaatga ttaaatcaag ccaattaaca tatccactac atcgcatact tattttttgt 78720ggtgagaacg cttaaaatct actcttttag caattttgaa atatacaata ccttatgttg 78780tatattacat tatgttgtat agtacgttga aacatacact acaatacgtt atcattaatt 78840gtggtcacca tgctgtgcaa aagatctcta aaacgtattc ctcctgtctg actgaaactt 78900tgtatccttt gcctaatatc tccccaatcc ctccaccacc agcccctggt aaccaccatt 78960ctctctgctt ccatgggttc aaatttttta ttttttgaaa tttttaattt ttatttattt 79020atttatttat ttatttattt atttttgaga tggagtctcg ctctgtcacc cagtctggag 79080tgcaatggtg ccatcttggc tcactgcaac ctccgcctcc tgggttcaag cgattctcca 79140gcctcagcct cccgagtagc tggggttaca ggtgcttgcc accaggcccg gctaattttt 79200gtatttttag tagagacggg gtttcaccat gttggctagg ctggtctgga actcctgacc 79260tccagtgatc cacccacctc ggcctcccaa agtgctgaga ttacaagcgt tgagccactg 79320cacctggcct aaaatttttt tttttttttt tttttttgag acggagtctc actctcttgc 79380taggctggag tgcagtggca tgatctcagc ccactgcaac ctcagcctcc cgggttcaag 79440cgattctcct gcctcagcct cctgagtagc tgggactaga ggtgtgcacc accacgccca 79500gctaattttt gtatttttag tagggacagg gtttcaccat gttggccagg atggtgtcaa 79560tctcttgatc tcgtgatctg cctgcctcgg gcttccaaag tgatgggatt atgggccacc 79620acgcccggcc tcaaattttt tagagctcac atataagcga gattgtgtac tatttgcgtt 79680tctgtgtctg gcttgtttca tcttagtata atgtcctcca ggttcatgca cgttgtcgca 79740aaagatggaa tttgctcctt tttaaagact gaatagtact tcattgtgta catatacacg 79800ccatattttc ttcatccatt cctttactga tggacatttg ggttgtacct gcatcttggc 79860tattgtgaag agtgctgtca tgaacatggg tgtgcagctg actctgaggt gttagaggga 79920ttacagctcc tccaaaagac caccgtcacc caaacctgct cctcctgccc tattttctgt 79980ttaggtaaag gcggctttaa ccccctgcag tgctctggcc tcagacctcc agatcttcct 80040ctatgcctct atgcctcttt ttctccaccc cctgcatcca atctgttagc acatcttatt 80100ggctctacct tcagaatcta cccagaatcc accacccacc tctcaccacc ttcacagccc 80160caccccggtc cagcccccat ctttgctggc ctggactaaa ccagttgccc ctccacccca 80220atctggtctc ttaacttcag tccttgcccc acccccagga ctgttcccca cacagcagcc 80280agagggcacc tgtgagccac tgagtcagga cctggctcct ctttgctcac aacctcactt 80340ggagaaaaag cccaaattct cctcacaggg acccacaaac tctgcccctg tgatccccca 80400tccccctcta ttcccactct cctctccact cactcggctt cagctacaca agttccctgc 80460tgtcccttac acaccaagca ctccccagcc tcagggcctt tgcacaggct gttccctctg 80520cctggaacac tcttccccca gatatctgct tggctccccc ctcacttcct ttgggtcttt 80580gctcaagtgt ccttctaaca tgtaactgcc tcacctgcac tgtgccaccc cactccccgc 80640ctctaggctt aatttccctc tacacccctg aagagcatct gccaagctat atttacttgt 80700ttattggtta ttgccaatcc cctgccccca ctagaatgcc agctccatga gggcagggac 80760ttctgtctgt tttgttcact gctattcccc cagagcctag aacacagcct ggcacatagt 80820aagtattcac taaataattt gtaatatgaa ttgtgccagt aaaatcttcc aggggcatca 80880agcccctgcc atgactaggt ggtaacatcc tcaccccctg tccatgtgct atctcctcct 80940gacctgcttg tctcattgtt ctaatggtgg ctcacgcctg taatcccagc acttggggag 81000gccgaggcgg gcagatacct gagttcagga gtttgagacc agcctggcca acatgatgaa 81060accctgtctc tactaaaaat acaaaaatta gctgggcgtg gcattgcacg cctgtagtcc 81120tagctactcg agaggctgag gcaggagaat cgcttgaacc cgggaggtgg aggttgcagt 81180gagctgagat catgccattg caatccagcc tgggccacaa gagcgaaact ctgtctcaaa 81240aaatatatat atatatttca ttgtggtaac atatgcataa cataaaatgt accatttttt 81300aagtgtttag ttgagcggcg ttaagtacat tcatattgtt gtgcaaccag gaccgccatc 81360catctccaga acttttgcat cttgcaaaac tgaagctctg cccccaggaa actctcactc 81420cccgctcccc cttcccctct ccccgactcc cccttccccc ctccccactc cccccaccct 81480actccacact ccccactccc ccagcccctg gcacccgccg ttctagtttc tatctctgtg 81540aatttggcta ctttgggtcc cccctgtgag tagaatcata cagtatttgt ctttttgtga 81600ctggtttgtt tcgtggagca taatgtcctc cagtctcatc catattgtag catgagtcag 81660aatttccttc ttttccaggc cgaatcgtat tccattgtgt ggatggacca cactttgctt 81720atctgttcat ccagatgggc acttggcttc caccttttgg ctattgtaaa taatgctgct 81780gtaaacctgt gtgtacaaat agctgagtcc ctgctttcaa ttcttttgga tatagaccca 81840gaagtggaat tttttttaaa tcaagatttg acccactggg gcccttagag gtctcattgg 81900ctctgaagct tttttttttt tttttttttg gacgctttga aactaaaaat aggagtgagg 81960ggcacagtga ggggggcaca catctctcgt gtcagcgttt tttaaaaaca ccccgggagg 82020aagatgtgtg aaatccctcc cttccccccg ctcccacccc ctccaagatc tcaaaatacc 82080tcttgtttta ggaagcggct gtgacatcag gcaggcagcg tgtggcatct gagacacaat 82140atcgcaagtg gctgggagcc cagagaaacc aggacaggcg tgctggggat gtggactaga 82200gatggagcta attttagtgg ctgaagaggc tgcaagaaga gagagaaaga ggggtgtgtg 82260tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtacgcaca gtgatagagg ctggaggggg 82320agaaatgaca gataaatcag cttgggcaaa gaaagctaat gggcagagga gcgagaccca 82380gctcagaagg tggtcagcaa atctaaagat gtgtgcccga gggtcaaggt ggtgggggga 82440ttcataggca agtggtagag aggctattcc atttgcagag gctctctctg tttgaggcgt 82500gattcacctg tgccgtcctc aaggccattc tgagaacacc actgttgttt tcctcctttt 82560atgagtaggg aaactgaggc attgaactgc ttctattctt cagtaagaag cagggggaac 82620atatggtaga agcaaagaaa tacaaacatg agggctctcg gggtctacgt gattggctgt 82680gacatccatg agagcggatc gcaggttgaa ggaaacactg gtggcagaaa gtagctgaac 82740atttggattt gggaatccca gtggacgtgg cgaaaattct ggcttttccc ttcacaggct 82800gcggggccac tctgacctgc ggtttcctta tctgtgaaat ggaacgatgc cacctgtctc 82860agcgttgttt tgaggatgcg aggagatgat ccgtgtaata tgcccactag ggggcctgct 82920ccagggtaga ttctcagcaa atggtagtca tggtttttgt tacatttggg gatattggca 82980ggtaaaaagg aaatacttca ttcattccaa aattgctcac tgaggttcta ctatgtgcta 83040ggccctgatg acacatcggt caacaagaca ggcctgcttt ctgcccttgt aaaacttcag 83100ttcaactgca ttgcactcat cagcctaata atccaggtaa attgtgatga gaataacaac 83160tagcatttac tatgagccct ttacaaatat taacccattt aatcttctaa agagcctata 83220agataagagc tcttgccctg cgcagtggct cacgcctata atcccagcac gtcgtgaggc 83280caaggcaggt ggatcacctg aggtcaggag ttcaagaata gcctgaccaa cagggtgaaa 83340ccctgtctct gctaataata caaaaattag ccaggcatgg tggcaggtgc ctgtaatccc 83400agctacttgg ctgaggtagg agaatcgctt gaacccagga ggcggaggtt gcagtgagtc 83460gagatcactc cactgcactc caagagtgaa actctgtcac acacacaaaa aaaaacaacc 83520tgttattatc cacattttac ctatgaggaa accgatgccc agagaggtta agtaactgtc 83580caaaggtcac acagctacgg agtggtagag ctgggattca gacccaggag tgtgatccca 83640gagtgtgtgt gtatgtttgt ttgtttgttt gtttgtttgt ttgtttttac cactgtgttt 83700tcctgcttct gcaatagaag taatcaccag taacactgag cagttgttat gtgccatgcc 83760cttaacacac atctccttgg atctttggaa agaatcctaa aagggttgtt tttcatgatc 83820cacattttat ggagagagag agatcaaagc atagagagag gaagtaactt gcccaagatc 83880ctgcagctga agactctagg gttgcaaatt tgggacggcc ctggaccctg cattccagct 83940tctagcagct cataggggga actctttatt tatttattta tttatttatt tatttattta 84000tttattttga gatggagttt cgctcttctt gcccagcctg gaatgcaatg gcatgatctc 84060ggctcactgc aacctccgcc tcctgggttc aagtgattct cctgcctcag cctcctgagt 84120agctgagatt acaggcatat gccaccacgc ctggctaatt taattttttt tagtagagac 84180ggggtttctc catgttggtc aggctggtct cgaactcctg acctcaggtg atccgcccat 84240ctcggccccc caaagtgcta ggaatacagg cctgagccac cacgcatgcc ctggggggga 84300ccacttttat cggtgcattt cttccatttt ccctgtgtct gtgtaaagat aaacaccccc 84360aagccccttg actatgaact gtgggccata attagttaat ggaaggtaaa tgttttagag 84420acggaaattg ctgtgccatt tttccccgct aggcattgtt gcctgcatgc taatgcaaca 84480caatgtgcct ttcttctgtc aggcattttt agacaaattc tattttccct aaaatatttt 84540gccaaagaaa atagcaaatg gggaagacat tcagaggctc aggcagagag aggacaccat 84600tcccttgggt ttaaacagaa tggcagagtg gataacagca cagatcttga gttaggtgga 84660tgccaatttg tgatttattt cccagcaaac caagatgctg gctctctgtg tgcctcagtt 84720tacttatttg tcaaatgagg agaataatgg tacctgtctc tcaccagctt accagttgcc 84780tctttagcta tgtctaatct gctattaacc acgcccacta tgtctttaat tccaagtatt 84840agaattgttt tcttcctaca agctgtctga tcttttttaa tcctgcttca tcttttgcag 84900tattgttttc ctacagcagg atttctcaac cttggcacaa ttgacatttt gggctaggta 84960attcttggcc gtgagctacc accctgtgct aagatactta gagcatccct ggcctctcac 85020cctactaaat gccagtagca gcccctcccc agttgtggca gccaaaaatg gctcagacat 85080tgccaaacga aatgtcccat ggagggtaga aacgccccca cttgagaatt gttctatagg 85140tattttcaag catgtcttac atttctttaa gtataatatg caaaagaaaa ggctaaatct 85200aaaaaaagcc cataatatgc gaagaatttt tataatcagt gtccaataac ttaagtatct 85260aaaattgtta tggctttttt tctgctgtct cttgtttcct gtgattcctc attctggtgc 85320cttgttttct tgaatgtctt gttatctttg gttgtgtgaa gctcattttc catgggacac 85380tattttttgt tttgttttgt tttgagacag agtctcgctt ggttgcccag gctggagtgc 85440agtggtgcaa tatcagttca ctacaacctc agcctcccag gcccaaatga ttctcctgcc 85500tcagcctcct gagtagctgg gattacaggc gtgtgccacc acacccagct aatttttttg 85560tatttttagt agaggcaggg tttcaccacg ttggccaggc tggttttgaa ctcctgacct 85620caagtgatca acccgcctcg gccccccaaa gtgctgggat tacaggtgtg agccaccgtg 85680cccggcatcc atgggacact gttgaaggga gttcattgag gcctgcgatg aaggcgaacc 85740ctccatggac aatttgcatt tactttttcc aggtgtctgg gaaactccca gtctaggacc 85800atcttagact tttagaccaa caatgtgttg agaatttagg tcaccagtgt ctgcaaaagc 85860cagcttgtgg ttataatttc tcaaaaactt ttgtttttct ccttttctgc aaagtgccaa 85920agtaacttcc tcaaaaatct ctgggaatgg aaagacggga gtaaattaac ttcaggtttc 85980ttacctgaaa gtgatagcct attggggccc catcctactt ggggagtggt gtgtctcctt 86040tgagactttc taacacgtgt gtaccctgga ctttgcccca cccctgctcc ctaggaggcc 86100ataaaacttg aagcagcagt tccatgggtt agacagatgc ccttggggca aaagtggttt 86160taatgctctg gtagatgctc aggttacctc tgggaaattc ttgacttcac ttatttattt 86220ggggctgata actactaatt gtcaggcctt tcttgtttca acaacatgga cttcagattt 86280tatgcaggat ttgtcatcgt tttcagcaag agagtcagtc ttattaccca gcttactgca 86340ttagaaatag atgtctgggc caggcgcagt ggctcacacc tgtaatccca gctgtttggg 86400aggctaaggt gggcggatca tgaggtcagg agttcgagac cagcctggcc aacatggtaa 86460aaccccatct atactaaaga tagaaaaaat tagctgggtg tggtggtgcg tgcctgtaat 86520cccagctact tgggaggctg aggcaggaga attgcttgaa cccgggaggc agaggttgca 86580gtgagccaag atcgcaccac tgcactccag cctgggtgac aggacgagac tctgtctcaa 86640aaaaagaaat agatgtctgt tgtgtggatt atttaaaaga gtagatggcc aagaactatg 86700acttatgcct gtcatctcag cactttgaga ggctaaggtg gagggatcac ttgaggccat 86760gagttagaga ccagcctggg aaacatagca agacccccat ctctgcaaaa gtaaaataaa 86820ataagttagt gtgcatgatg gtgcaggcat acctctagtc ctagctactc aggaggctga 86880ggcaggagga tcacttgagc ctaggagttt gaggctacag tgatctatga tcatgccact 86940gcactccagc ctgggtgaca gatcaagacc ctgcctctaa aacataaaaa taaatacaaa 87000ttaagttaaa aaataaaata aataagtaat agaacatcca gcacagttct tggcatgcat 87060tgactgttgt tgtttgtttg tttgtttgtt tgtgacggag tctcactctt gttgcccagg 87120ctggagtgca atggcatgat cttggctcat cataacttcc acctcccagg ttcaggtgat 87180tctcctactt cagcctcctg agtagctggg attacaggca cgtgccacca ctcctagctg 87240ttttgttttg tttgtttgtt tgttttgtat ttttagtaga gatggggttt ctccaagttg 87300gtcaggctgg tctcaaactc ctgacctcag gcgatctgcc agcctcggcc tcccaaagtg 87360ctgagattac agacgtaagc caccacgcct ggccagctgt tttgattgtt aaatgaaggt 87420ggtatgaaag ggaaggaaga acagtgacat ttgcaaggga cactccctgg agggcagggc 87480aagggggctg tggaggggag aagtcagaga gtatgataca ggttgccttg ggtgatgttt 87540tagattttag ccaacattgg caaagagcct catttatctc tcagagtagc tctggctact 87600ggaaatgctg cacaacttca ggcggacttt ctagaagaaa actcttggcc aggtgcagtg 87660actcacacct gtaatcccaa cactttggga ggctgaggca ggtggatcac ttgagctcaa 87720gagtttgaga ccagactggg caacgtggca aaacctcatc tctacaaaaa aaaatacaaa 87780aattaaccag gcgtggtggt gcatgcctgt atcccagcta cttgggaggc tgaggtggga 87840ggattgcttg agcctgggga ggtggaggtg gtagtgagcc aagattgcac cactgcactc 87900ccatttgagt gacagagcaa gaccttgtct caaaaaagaa aaaaagaaaa gaaaagaaaa 87960gaaaattctc tctgggattc aatcctggcc cacacagcat tggcttcact tcacctcctt 88020ctcccctgag atacacagca ccattccccc aagcttcatc aacttaatct ctgatctggg 88080tgctgtgact tgtccccatt cctggccaga atttaaggta gggatgaacc cactagccct 88140ccatcacgca ctctgccata aaagcacacc acgtgctgat tgctgtcttt ggtctccttt 88200ctgccttgcc ctctagactc tgagctgctt ggagacagag gccagttttg tccatctcca 88260aatcccctaa agtcctgtgg ccagcaagca ggtaggacat ctgaaagttc gtcagagagg 88320gaattgcttt tctcttgaga tgcaactaga acaagaatct tattgacctg gagtagcttc 88380aaggttgtaa gagtatgtgt cagggttctc caagaccact ctcaggtttg aaggtttgct 88440aaaagggctc acgggaccca gaaaagctgt gaaattcagt tatggtttat tacagtggaa 88500gaatacagat aatacagatt aaaatctgca aagcaaaaga tgcacaaggc aatgtccagg 88560ggagatcagg catgagcttc cagctgttca ctcccagtgg agttatgcaa acagtgctca 88620attctcccag caatggtgtg tgacaatgta cagtgtaccg ccaaccagag aagctcacct 88680gagccttggt gtccagggtt tttattgggg ctcagttaca ttgacatgga gcacccatgt 88740gactgacttt aactgctggg tctccagcac actccaagat caaactgata ccgtgtgtcc 88800cagggcccca gctgaacaca aacaggcagt caccatagat cccattgtga gcataagcta 88860ccaggcatgg cccaaagccc tagatataca gatattcttt ccaggagcca gccaagggcc 88920agtccttcct ttggaatatg cagagtttga actccccaac cccaaggagt taactcttta 88980ctacacagaa tataaatctc accaagtctt tcttcttgtc aagtcctctc aaggtgaccc 89040attgctttta gcagtgtctt tgagaccctg cgtcatctgg ccttgaccca tatcacctgt 89100gttatctctc cactctagct acattgaact tttctttttt gagatgtggt ctcactccat 89160cacccaggct gaagtgcagt ggtacagtca cagctcactg cagcctcaaa ctcctgggct 89220caagtgatcc tcccacctca gcctcctgag tagctgagcc cacaggtgca tgccattaca 89280cccagctaat atttttattt ttagtaaaga tgggttctca ctatgtttcc caggttggtc 89340tcaaactcct gggctcaagc agtcctccca tcttggcctc ccaaagtatt ggcattacag 89400gggttagcca ccacatccag cccattgaac tttttaagga tcccctagca tcctatactt 89460tctgtcactg gatagccttg gaattatttt tccttctttt tgaaatactc ttcttctttc 89520caccctttgc tgtcaagtct cagaataggc attatttcct ccaaaaaccc tctcctgacc 89580ctccaaatct ggatgaggac acttcctttg cccagagagc acctgtttta atcctctcag 89640gtggctataa taaaatacct taaactgggt ggcttataca cctcagaaat ttattttcca 89700cagttctgga ggctgggaag atcaaggcac tgacagattt ggtgtctgat gaggggccat 89760ttcttgtttc gtagaagggg tcttcctact gcatctttcc atggtgaaaa gagttgaggc 89820agctctctga aacctctttc atgagagcat gaatccctct gtcttcatga tctaatcacc 89880tcccaaaggc cccacttcct aatatcttca cattggtgac taggtttcaa catatgaatt 89940tgagaaagac acagacattc agaccatagc agtgctcttc caccaggttt tttatccccc 90000tgtattataa ttgaggttta aattatctgc tttccttccc ttagattgta agctccatga 90060gagcagggcc ctacccatcc agtcattgtc ctatccccca tgactacaac ttcctgggta 90120cataattaat atttattata ttatgtagca aaggtatgct gccatactaa gagacccaaa 90180aggccaccgg attaaaacct taaagaaaaa aaaataattt ctctcctata atagctgcaa 90240ggttagccat gcaggttggc agggaagctc acttccacaa agtcactcag ggattcaggc 90300tcctgttgcc ctcttctttt ctaccaccaa atgatcttca

gcaccatttg cacaatcaaa 90360acttaactgg tcttgaatag gcagaccttg aatttctgaa gtctcagacc caaaagtggc 90420agctgtcact tccactgaca tatcactgat ggaaacttaa tcatgtgatc ataccaaact 90480gctagggatg ctgggaaatg tagttttgtt gggaactcca tgacttggct aaaattccat 90540tactgtagaa gatggtgggg gatgggggag tggtggacat ccagtggttg ctaccatatt 90600tattgaatca aattgtcaaa caggacctat ctgataaggg gttcttttcc agaattaact 90660gaagtattaa atcaggggca aaggcatgtc acctcatctt tctctcccta tattggcttt 90720ctagggctgt tataacagag taacatgaac ttggcggctt aaaacaacag aaatttattt 90780tctcttagtt ctggaggcta gaagcctaaa atcaaggtgt cagcagagcc accttgacaa 90840ctgctctagg aaagaattct tccttgcctc ttctggtggc tcctggcaac ccttggtatt 90900ctttgtctgg catccacttc aatctctgcc tccatcttca tttgcctttt ttctctgtgt 90960gtctatgtcc tttcctcttc ttagaaggat accagtcatt gaatttaggg cttactctaa 91020atccaggatg atctcacctc aagatcctta attagttaca tctgcaaaga gcttatttca 91080aaacaagatt gcattctgag gtttcggtaa acacgaattt gggggaaata gtattcaact 91140caattcactg ctttacttaa gaaaagagac catgaagtga gcctccttct gcttgagaga 91200gagagcgagc ctttctgtgc aataggtcaa tgaatggatg cagctgaatt ccacataact 91260ttataaaaat agatggccag cccatggggt ttgctgaccc ctgcccaaaa attccaaagt 91320caacagcagt ctctttttta atcatttctc tattttttaa tttattttta tttttatgtt 91380gagatagagt cccgctctgt cgcccaggct ggagtgtagt agtctcggct cactgcaacc 91440tctaccttcc agatacaagt gattctcctg cctcagtctc ctgagtggct aggagtacag 91500gtgtccgcca ccatacccag ctaatttttg tatttttaat agaaacaggg tttcaccatg 91560ttggccaggc tggtctcgaa ctcctgacct caagtggtcc acccacctcg gcctcccaaa 91620gtgctgggat tacaggcatg agccaccatg cccggccagg attttcttca ttttaacagc 91680attcttactt gtcccacatc cattctatcc tgggtctaat tagataacaa aatctacaga 91740tcttgtttaa ctgacattgt cctgggggat actttttatc ttttgagaca aggtctcact 91800ctgttaccca ggctggagtg cagtggcctg ataacagctc actgcagcct cgaccacctg 91860ggttcaagcg atcctcccac ctcagcctcc agagtagctg gaaccacaga tgcatgccac 91920cacacctggc taatttttaa atttcttgta gaggtggggt ctccctatgt taccaaaggc 91980tggtctcaaa ctcctgggct caaaagagcc tcccacctta acctcccaaa gtgctgggat 92040tacagatatg agccactgtt tccagccttg gaaatatagt ctaagaactg agtcaatagg 92100cgattttgtc attgtgtgga catcatgtag agaacttaac acaaacctag atggtataaa 92160ctactgcaca cctcagttat ggggcatacc ctattgcacc taggctgcaa acctgcacag 92220caggttactg tcttgaatac tgtaggcagt tgtaacacaa tggtaagtat ttgtgtatct 92280aaacatatct aggccgggca cggtggctca cgcctgtaat tccagatcac ctgaggtcag 92340gagttcgagc ccagcctggc caacatggcg aaactccttc tttactgaaa aatgcaaaaa 92400ttagccaggt gtggtggcag gcacctgtaa tcccagctat tcgggaggct gaggcaggag 92460aatcgcttga acctgggagg tggaggttgc agtgagctga gatcatgcca ctgcactcca 92520gcctgggtga cagagcaaaa ctccatctca aaaaaataaa aaataaaaaa catatctaaa 92580cagaaaaggt acagtaaaaa tacagttata accatatggg accaccattg tataggcagt 92640ccgctgttga tcaaaacata tcaaaacatc gttatgtagc acatgactgt accataaacc 92700acacggcttc aaacaaggga aatgtattct ctcactgttt tggaggccat aggtctgaaa 92760tcgaggtgtc accagggtcc ctccaaagga tccgggggag gatccttcca ttggatttgg 92820agttgcttca ctccagtctc tgcctcagtg gtgacagggc gttctcctct tccctctcaa 92880agttccctct tctgctgtgt cataaggata catatgactg catttaggcc ccactcagaa 92940aatccaggaa taaactcttg ccctcatatt cttaactaaa tcgtacctgc ataccttatt 93000ttttctaaat aaggtagcat tccagggatt aggacatcaa cataacttct ggagggttca 93060ctgttcaacc cactacagcc agaatgcgct ttgaattcag gttctgacat ctgggactgc 93120ctcccacgta cacacaccac taccttgtac tgaatgcctg aagggttctg cccccacctc 93180cactccccca aatatttgct gtggacctga gaaagctgac ttcatggaag cttcattcca 93240ttgttctaag gacttttcat acattaacaa atgtcttctc tctatgggga aaaccacaga 93300gaaatcaaga cagagtgggg ttaagtaact cacctgagga ggaacagtaa gtggcagagc 93360caggattcaa accaacatgg ttttgcacag ttttgacatc atttgcaaca caaatattgt 93420cacagatacc tttttgagca tctactgtgc taaccgccag gaaggaaaag aacatggggc 93480cgggagagct cttgacaggg gacagggctg gccatggagg tctgtgtctt ggtggaagat 93540gctatggttc tctttttttt tttttttttt tgagatggag tcttgctctg tcacccaggc 93600tggagtgcag tagtgcaatc ttagctcaca gcaacctcca cctcccgggt tcaagcgatt 93660ctcctgcctc agcctcccaa atatctggga ttataggcac acaccaccac gcccagctaa 93720tttttgtatt tttagtagag atggggtttc accatgtggg ccaggctggt ctcgatctcc 93780tgaccttgtt gtgatccacc cgcctcggtc tcccaaagtg ctgggattac aggcatgagc 93840caccacactg ggcaactatg gttctctttt aactccttgt gctgaaatta ttgcagaagc 93900ccaggccagt tcatccccag aaagtgaggc ataaacaggc agagctctac agaaacagag 93960aatccacgac tggtttgatg gaggctgcct cactacctac agaatgggct ctgggtggat 94020tgttctatct ggggagccag cccacccacc agtctcagcc cttggcgact ctttcctgct 94080gtcacagcag ctggacattc agaaaccgaa acatgacagc cttccctccc tgttcctgcc 94140cagtggagtg gaaacccctc gggacccaca taccgagcgt gcacagcagc acagagttgc 94200acagttaaca cagcgcttct tctccagccc tccggatgca agctgacaga ttggcagctg 94260gctgacttcc aaggtccagt gagttcttgg cagtcgcttt ctgacctgga cgagtggctg 94320ccacctcctg gaacatcagg ctgccccctt ggggagaggg tgacggtctc tctggaaaga 94380ctgtgagctt tgaggtggtc atcaaaagcc attcttggaa acattctttg agctgtaccg 94440tgcaattcgg tcaccaattg cacgtatttg gatattaata tccgtatgtg gatattaaat 94500tggttttggg ttttgttttg ttttgattgt ggcaaaatat acacaacaat cctcctgcct 94560cagcctccca agtagctaca ggcatgcacc accataccca gctaattttt ggatttttta 94620aatttgtttg tttgtttttg ttttttgaga tggagtgtag cactgttgcc tgggctggag 94680tgcagtggcg cgatctcagc tcactgccac ctccgcctcc tggattcaag tgattctctt 94740gcctcagcct cctgagtagc tgggattaca ggcgcccgcc aacacgccca gctaattttt 94800tgtattttta gtagagatga ggttttacca tgtcggccag gcttgtctcg aactcctgac 94860cttgtgatcc acccgcctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgcg 94920cccggccgat ttttgtagtt ttagtagaga cagggtttca ccatgttggc taggctggtc 94980ccgaattcct gatctcaggt gatccaccgc ctcggcctcc cgaagtgcta ggattacagg 95040catgagccac cgcacacagc ctaaatgctg tgcctcacgc ctgtaatccc aacactttgg 95100taagctgagg ccagaggatt gcttgagccc aggagtttga gaccagcctg ggcaacatag 95160gaagacccca tctctataaa aaataaaaat aaattagcca ggcgtggtgg tgcaggcctg 95220tggtcccagc tactcgggag gatgaggcag gaggatcgct tgagcccaag aggtcaaggc 95280tgcagtgagc tgtgattgtg ccactgcact ccagcatggg tgaaagagca agaccttgtc 95340tcaaaaaaaa ttaagcgaaa tttaaaattc tgtttctcac tcacacaggc tgcacttcaa 95400gtgcttaatc atcccttgtg ggtggtggct atcatattgg acagcatgga tagagaatat 95460ttttatcagc gtaggaagct tcatcagaga ggaccgctca gaggcctgtg gggaccagca 95520cagtgcagta gaagacacag gccagctggt gagagactgg tcttctgatc ccagatctgt 95580ccctcacttg ctaggtgacc ttggacagct ccctcagtcc ctctggagtt ttctcttcat 95640tgttaaatca ggaaattggc ctcagtgaat tctgaggccc catctacttt tttttttttt 95700tttttttttt tttttttaat tgagacagag tctcgctctg ttgaccaggc tggagtgcag 95760tggcatgatc ttggctcact gtaacctccg cctcccaggt tcaagcaatt ctctgcctca 95820tcctccccag tagctgggac tacaggcgtg caccaccatg cctgggtaat ttttgtgttt 95880tcagtagaga ccgggttttg ccatgttggc caggctggtc tcaaactccc aaccttgagt 95940gatcctcccg cctcggcctc ccaaagtgct gggattacag gtgtgagcca ccacgcctgg 96000cctcatctag ttctaaatgt tatgacccac tcagctctga agacaaggga ggaacatcct 96060ctcagtctag ctctgacatg cagaagcctc tcaccctgtc ccccaggtca taaaggcagg 96120cgtgttgtga agagcacaga atgggctgag aaaaatatgc agggattgcg tctatctccc 96180ttccttccgc acgtttcctt gtcggcacca cctgcctcta ttccgcgccg cacacacacc 96240cgccttctct ctgtctcgga ggaagacagg atcttccatc ccccaaatcc tgccctgatt 96300cctactctga agcctctgcc ctgactcctt taagctccct gggaatacag cccatctcct 96360atgccctcct catcccagta gttcctacct tccccaaaat cgctttggga aagtccccca 96420atgagtaacc agctgtccta catgggcatc tcagaacttc tcttctgttg ttgttgttgt 96480ttgttttgct tttgttttga gacaggatct ctctttttca cccaggctcg agtgcagagg 96540tgtgatctca gctcactgta gccttgacct cccaggctca ggcgatcctc ccccctcagc 96600ctctggaata gctgggacta caggcacacg ccaccacacc cgggcaaatt ttttttagga 96660cttttggtag aaatggagtt tcgccgtgtt gcccaggctg gtctctaact cctgggctca 96720agcgatccgc ccactttggt ctctcaaagt gctgggacta cagacatgag ccaccacacc 96780cggcagagct tctatttctt gagtgtgttc tcagccatgc taagacattt tctcttctca 96840gcctgatgat gcttttggct tgtgtttctt tgtttttaat taccccttcc cagtcgctgt 96900catgggatca tgagggtctt ctgtccatct agatgacacc tttcttgtgc cacgtgtctc 96960caacattccc tggtttttaa acccttattg ctttcaagat actatccaag ctccttaatg 97020tggcacattg tccttcgctg ctatctgcct gctttttttt tgagacagag cctcgctcta 97080ttgcctaggc tggagtgcag tggcgcaatc acagcttact ctgcagcctc gacttcttgg 97140gctcaagcaa tcctcctgcc tcagccttct gagtagctgg gaccacaggc atgcaccatc 97200atgcttggct aatttatttt tatttatttt tatagagaag gagtctccct atgttgccca 97260ggctggtctc aaactcccgg actcaaagtt cattgcagtt tcaatttttt ccttggctca 97320aggatcctcc cacttcagcc tcctgagtag ctgggactac agacgggcac caacacacct 97380ggctaatttt tgtatttttt gtagagatgg ggtcccacta tgttgcccag gcttctatct 97440gcttttatct caccttccac tcttccatcc ttcctttctt ttcttttatt tcctttccct 97500tcccttgcct tccttttctt tctttctttc tttctttctt tctttctttc tttctttctt 97560tctttttctt tctttctttc ttgacagagt ctggctctgt cacccagact gaagtgcaat 97620ggcaagatct tagctcactg caacctccac ctcctgggtt caagcaattc tcctgtctca 97680gcctcccgag tagctgagat tacaggtacc tggcaccaca cccggcaatt tttttttttt 97740ttttagtaga gacggggttt cgctatgttg gccgggctgg tcttgaactc ctgacctcag 97800gtgatcctcc cacctcagcc tcccaaagtg ttgggattaa caggtgtgag ccactgtgcc 97860tggccttttt tttttttttt ttttttttta agacaggacc ttgctctgtc actcaggcca 97920gagtgcagtg gcactataat cactttctgc agccgtgacc tcctgggctc aagggatcct 97980cttgccttgg cctccctagt agctgggact acaggcatgt gccaccacac tggctaattt 98040ttaaaacttt ttgtaggccg ggcacggtgg ctcacacctg taatcccagc actttgggag 98100gccaaggcgg gcggatcacg aggtcaggag attgagacca tcctggctaa cacagtgaaa 98160ccccatctct actgaaaata caaaaaatta gccaggtatg gtggcgggcg cctgtagtcc 98220cagctactcg ggaggctgag gcaggagaat ggtgtgaacc tgggaggcgg agcttgcagt 98280gagctgagat cacgccactg cactccagcc tgggcgacag agcgcgagac accatctaaa 98340aaaaaaacaa aaaaaaaaaa caaaaaactt tttgtagaga tggattcttg ctaggttgcc 98400caggctggtc tcaagcttct aggctcaagc agtcctcttg cctgtgcctc ccaaagcctt 98460gggattacag gcgtgagccc ccacacctgg tcctaaccca ctttctgaac ttccaaccac 98520accattttgt cctaatattt aagtcacacc ataacatgtc ccacttcaga aatgcctacc 98580aaagtagtct tcaaatcttt ttaaatcagt ggaccctttc taccaaacaa atgttatttt 98640ttaaatattt attttagagt aatttagact tttagaaagg ttgtagctgg gcgcagtggc 98700taacgcctgt aatcccagca ctttgggagg ccgagacagg tagatcacct gaggttgggc 98760gtttgagacc agcctgggca acatggtgaa accccgtctc tactgaaaat acgaaattag 98820tcaggtatgg tggcacgcgc ctgtagtctc agctactcgg gaggctgagg caggagaatt 98880gcttgaaccc aggaggcgga ggttgcagtg agctgagatc gcgccactgc actccagcct 98940gggtgacaga gtgagactcc atctcaaaaa aaaaaaagaa aagaaaaaaa agaaaggtta 99000taaatatatt ataaagagtt cccacatacc cttcacccag tttctcctgt tgtttgtatc 99060ttatattatc accatatgct tgtcaatgct aaggaattgc tgggtgcaga gtggcacatg 99120gctgcagtcc cagatactca ggaggccaag gcaggaggat atcgcttgag cccaggagtt 99180caagtctagc ctgggcaaca cagtgagacc tcttttctgc aaaagaaaac aaataaaaca 99240tctaaaaaag aatacactgg aggcggcgtg gaaacaagga tctcatttgg gagttgtctg 99300caatgttctg agcaagcagt aacggaggcc tcaagtcagg gctgtggtca tggaggtggg 99360gaggggtggt tggtttcact atctgtgttg acttaatttt agatttgcag actcaactga 99420gtatgaactt taagagaaag agagaggcca ggcacggtgg gtcacacctg taatcccagc 99480actttaggag gccaagtggg gaaggccgct tgagcccagg agtttgacac cagcctgggc 99540aacatagtga gacccctgtc tctacaaaaa aaaattttta aattagccag gcagggtgat 99600gtgtccctgt aatcccagct actcaggaca gtgaagcagg aggatcattt gagcccagaa 99660agttgaggct gtagtgagct gtagttgcac cattgtgctt cagcctggga gacaaagtga 99720gaccctgtct caaaaaggag aatggggaga gagagagaga gagagaagga gaaagagaga 99780gaaagagaga gagggaagtc aaggagaacc ccacattttt tgacatggtg tattagtctc 99840ttctcacact gctaataaag acatacctga gactgggtaa tttataaagg aaagaggttt 99900aatgcactca cagttccaca tggctgggga ggcctcacaa ccatggcaga aggcaaagga 99960gaagtaaagg catgtcttac atggcagcag gcaagagagc ttgtgccatt tataaaacca 100020tcagatctca tgagacttat tcactaccac aagaacagta tgggggaaac tgcccccatg 100080attcagttat ctccacctgg cgccgccctt gacacgtggg gattattaca attcaagttg 100140agatttgggt gggaacacag ccaaacccta tcacatgggc aagtgaaagg atgggtttgc 100200catcaaataa aatggggaag gagactgact aggtgggcag attaggaact cagctttcta 100260tgaagtgcct actgatggat agagatattg tgttggccat ctattaggtt ggtgcaaaag 100320taattgcggt tttgccatta aaagtaatgg caaaggaaat aacctttgca ccagcctaat 100380aggaattgga gtctaaaatt caaaaaaggt aagtcagagc tggagatcca aaggcaggag 100440tcagcctcct gtggaggcta tttaaggaac tgaataaggg catagatgca ggagagcacc 100500caggactgag cccagggctt actctccatc attaaagagg ttggggaaga tgaggaggag 100560ccagcagaga agactgaatt ggagcaaatc agaagaatgt gggtgctggc tgtcatgcaa 100620ggaaagtgct aagccatttc aagtatgagg gaatgatcaa tgatgtccac tgatgctgat 100680gtgttgactc aaatgaaaaa tgagaatcaa ccattggatg tagtggcatg gagatctttc 100740gtgacctgag ccagagctgc ttaggtgaag aggtgaaggc aagaggctac tggaaggatt 100800actactagct cttttaaaga gttctgctgt gaagggtaga ggaagagaga tggggcatgt 100860gttagctggt gggggaagtg gatttcagag gtttgtttcc cttaaaaaaa aaaaaaaaaa 100920gaaaaaagaa taaagaaaaa aaaaaggcca ggcacaatga ctcacacctg taatcccagc 100980attttgggag gctgagacct cgggaatttg agactagcct ggacaacata gtgagacccc 101040atctctacaa aaaaaatttt tttttaatta gctgggcatg gtggtgcatg cctgtggtcc 101100tagctacttg ggaggctgag gtgagaggat ctcttgagcc tgggaggtcg aggctgcagt 101160gagctatgat cacaccactg cactccaggc tggacaacag agcaagaccc tgtctcaaaa 101220aaaaaagatg ggagacctaa cagcagattt tatgctgata ggaataacct attaggggag 101280aaaaacatga ggatgctgga ggaagaagag tgtcaggagg acatctcttg gtggacgaga 101340ggggatggca tttggtgtac aggtggaagg tttcacttta gatgacagca cacacagtta 101400tctatagaaa caggagaaaa tgcactatat gggcatacat gctgggaggt agagagtaaa 101460taatagtggt ggttgcttgt ggaaattctc ttctaatgtt tttatatttt tatggtttat 101520caaggacaat ttatattttt acagtttact gcaaacaaca agttctaatt tattcaataa 101580ttatttgtgg gtagaccgag tgcagtggtg catgcctgta atcctagcac tttgggaagc 101640caaggtggga ggattgcttg aactcctgat tcacttctga gcttgaatca ggagttcgag 101700atcagcctaa gcaacatggc aaaacactgt ctctacacaa aatacaaaaa ctagccaggt 101760atagtggcat gcacgtagtc ccagctattc gggaggctaa aacgggagga tcatttgagc 101820cctgaaggtg gaggttgcag tgagccaaga gcgagccact gcactccagc ctgggtgata 101880gaataagacc ctgcctcaaa aagaaattct tattcttctt cttcttatta ttatttgagg 101940agacatttac tttgtaccag gcgctgtgct agatgctgga gatacagaca tcaacaatga 102000caaggctaag tgcctggcgt atttgtactt tgagtctaat aaaagacatc acacagacac 102060acaacacaca cacacacaca cacaggattg tcaaaggatc aaccatttca catgtcaaga 102120tcaggaatga tattggtcta ctactgcctt accatatctc ctaccatgac ctcatcttcc 102180tcttgccaga ttttaagtct ttatacctca actcccagaa ctctcttcgc ctcacaccct 102240atcacaatgt catccgtacc ccacggccaa tactccatca ttcgggaaag caaagttcca 102300aagcgtcaag attgtatcaa tggacctgtc tctatggcaa cagtcctgaa tgagccaagc 102360aaggtaaccc tggagatggc gtgaatgaga aagtggcctg ttgccacgga gacgtgctga 102420atgggaaggc ccccacgagc caggctatgt cacgaagccg aaacagtcag catgaagtcg 102480gtatgtctat tttcaactcg gaattacaaa aatacatttt aatagagctc atgacccatc 102540tccttcctcg tccctgcctc ccaccccact cttcagcctt catcctacaa cacaatcgag 102600cctcaccagg aacccttcaa acccctcaag gacaccttac tgttccttca gtacacagtc 102660cccttcctgg gctgaggtgg tattcctttg accaactact gtctcccctt tgggaccaac 102720agtattctca aaagccatga gcttatggga agaacattaa ctacattctt tggggcaaga 102780acagttgctc acctgtgaac cagctcagct tgcatctgtg agaatgattg caatgggtag 102840accagttctc catcaaagaa tggccctagc accccacaca cagtggtata atctgatcat 102900gctggtgtat tgaacatata atgttagtgc cacatgaaag gaatttgtaa aaggacttag 102960tgcctagaaa ggtacctttg aagatcttgg aatctctgaa acttacccag gttccttata 103020ccctgctcaa agtattcctc catttatttc ttcattcatt agttcttttg tttcaccaca 103080tatatatttt tgaaacgggg tctcactctg ttgcccaggc tagagtgcag tggcaagatc 103140gtggctcact gcagcctcaa cctccccatc tcaagcagtc ctcccacctc agcttcctga 103200gtagctggga caccacaggt acaagccacc acgccaggct aattcttgta atttttgtag 103260agacggggtt ttgccatgtt gcccagtgta ttcgtttgtt ctcacattgc tataaagaac 103320tacctgagac tgagtagttt ataaagaaaa gaggtttaat tgactcacgg ctccacaggc 103380tgtgcggaag gcatggctga ggaggccaca ggaaacttgc aatcatggcg gaaaatgaag 103440gggaaacaag cacatcttca catggtggca ggagagagag agtgaggggg ggagtgctac 103500aaaaccaggt ctcacgagaa ctcactcact gtcatgagaa aagcaagggg gaaatctgct 103560cccaggatcc aatcacctcc taccaggtcc ctcccccaac attggggatt acaattcaac 103620atgagatctg ggtggggaca cagagccaaa ccatatcacc caggctggtc tctaactcct 103680gagctcaagc aatctgcctg ccttggcctc ccaaagtgct aggattacag acgtgaacca 103740tatttattaa gcattgttac agcaaagaga agcattgttg cagcataaca attggaagac 103800tccattgatg gacgtctcca tcaacaagaa ctgtcggata aactatggta cacccatccc 103860ttagcgtgtt atgaagtcat tacaaaaaga agaagcagat ctctgagtgt caataagagc 103920tagtacttat agggtgtcta ctgtatacaa gtgctgttag aaagtgagta ttaactcatt 103980taattcttgt aacaagcctg tgaggtggat tctttcatat ccccatttta cagagaagga 104040aataggaatc tctatatcca agatatgtta tcaggtgaca aaagcagttt ttgaatggtg 104100ccgccatttt ctcgtaagag caaatctgga agattccatg agaaattaat aattgtgttt 104160gcctctgtag cggcaccctg aaagatttgg aagtaggtgt ggaaaggaaa cttactttct 104220tgtgtctttc tgaattttgt actgtctacg cgttttgtct ttcacaaaac caaacagaaa 104280atgaccattt ggtgcatttt gtgtgtcagg cattcttcta gtctagagaa gcacaggaga 104340gcaaaatatt ttactgacga gaaaaatgag gcatggagaa gttaagtgac ttgcccaggt 104400agcagagctg ggattccaca tcatagggtt tatacaggaa acaggtaaac agagctgtgc 104460ttgtgtgtgg gtatgtgtgt acacatgcat acatgtgtgc atgtgtgtgt gtgtttgtgt 104520gtgtgtgaat gtgcttgtgt gttgggagag ggaaatggca agagaagaac ctacagaagg 104580tcagcaggaa ccaacccatg ttttgaggag tttggacttt atcctgaagg cacaagggag 104640ccatggaagg atttagacaa ggggtggttg tgcttagctt tttatttaga aggatgactc 104700tggctgaagg gtgatggccc agaatacagg tatatgtgaa ggactcctcc tgccctagta 104760ggaggatgcc cacccaccct ctctgcccag tgcagtatca aagggcaaat tgggtacaga 104820gaattctcac caagctgggt agaatccact ctgatgctgg ggagtggaca ctgaatgcac 104880cagcctctcc tcctgctcaa tccctgaatt gaagctgttc cactaatgtt agggatcaga 104940ttcccttcat atatatatat atatatatat atatatatat atatatatat atataatttt 105000ttttttgaga cagagtctcc ctctgtcacc caggctgaag cccattgtcg cgatcttggc 105060tcactgcaac ctccacctcc caggttcaag caactcttgt tcctcagact cccaagtagc 105120tgcgattaca ggcacccgcc accacacctg gctaattcta tatttttagt agagacaggg 105180attcacctat gttggccagg ctggtcttga gctcctgggc tcaagtgatc agtctgcctc 105240agcctcccaa agtgctagta ttacaggcat gagccaccat gcccgtcctt tttatattac 105300ctttttttat agagatgtgg tttcactatg ttgaccaggc aggtcttaaa ctcctggcct 105360caagcgatcc tccctcctca gcctcccaaa atgctaggat

tacaggtgtg agccactgca 105420tctgtccaga ctctgttctc cataaagctg gcatatggaa agagggaaga ccatccaggc 105480aatatcgaag tcccattggt gctgatgtgg ctgctgagac cacatgaatg gatgcattct 105540gactctgcca cctctcagct atgtgaccct gggccagtca gcaagtccct ctataactca 105600gttttctcat ctgtaaaatg gcgtcaacag tagccaaccc cagcaaatac tgtgaaatat 105660acagaacatc attataatgg tgaggatgat agagatgcta tgttatcaga atacctgggc 105720ttgaaccagc tccccttctt gcaagctgtg tgacttggag ctgatgccca aacctctgtg 105780ggcctcattt gtttcatctg ttcaatgggg ataataacac tcttacttca tacagttatg 105840gaggatttat tgaaataatt gacatacagc tcttagaaca gtatccggct ccttgtaagc 105900gctcaagaaa tattacagac tgttgataat aatgcaatac tactaccaat aatatggcca 105960ggagcaatgg ctcacacctg taatcccagc actttaggag gcagaagcag gctgattgct 106020tgagcacggg agttcgaggc cagcctgggt aacataggga gactctgtct ttacaaaaaa 106080taaaaataaa aatacaaata attagccagg tatggtggtg catacctgta gttccagcta 106140cttgggaggc tgaggtggga ggattgcttg agcccaggaa gttgaggcta cagtgagctg 106200tgatcacacc actgcactcc agccagggca acagagtgag accctatctc aaaaataata 106260ataatggccg ggcgcgctgg ctcatacctg taatcccagc actttgggag gccaaggcgg 106320gcagatcact tgaggtcagg agtttgagac cagcctggcc aacatggtga aaccccatct 106380actaaaaaca caaaaattag ccgggtgtgg tggcggggtg cctgtaatcc cagccactca 106440ggaggctgag gcaggagaat cgcttgaacc cgggaggtgg aagttgcagt gagccgagat 106500cacaccactg cactccagcc taggtgacac agtgagactc catctcaaat aataatatga 106560gtaataataa taatatcatt tttatcatca ttcttactaa cagtctctca ctccttgccc 106620tgcagttttg cctgttttct tggaataaca ctcttccaca cctttcccct cagggatggt 106680tcacgtttag catcatgacc cacccctggg gattagttag ctcatttctg gaaagcactt 106740tggagctgta ggtgctttgc aggctggaaa catcacggga cttgtaccat atttaagcaa 106800tgccagatta ttctgcctgg cagggggagg acacagagga tacggccctg gtatcttttc 106860tccctgccta cctcagcttt gctctgaacc attttctgtc ctgttcaggg cagcctgggc 106920cacttgccac ttccagcttt ctcgggagag gatgccttcc tgatggcacg cctcttaaca 106980cacacctggt gctgttgttg aaaaagcaac aattgactcc agcgccagca ctgagaggct 107040tgtccttaaa attagcagga gctgttggaa ggtcgctgtt agctcttttg actggaacac 107100actgttcccc aggtggcatg aggctgaata cagtgcaggg attggctctg ctctcaggtg 107160gcctgctcca cgctcctgag ctccgggtgg aagctgtgac cattatttcc ttaacagaaa 107220catatatagc agcattaact atgaacctta ttactgtgtg tgtgtgtgtg tatatgtgta 107280tatatatata tgcacatatg tgcatatgtg tgcctatgaa cctgttctga gcactttaca 107340aatgtcaatg tattttatcc tcccaacaac ccattttata aataagactt gaggcacaga 107400gaggttacgt tactgcccca agatcacaca gctggagagt ggtgaggcca agatttgaac 107460atatgtacca ttgtaccata tgtaccaact ttttttttct ttttgggatg cattcttgct 107520ctgtcaccca ggctggagag cagtggcatg accacggctc attacaacct caacctccag 107580gttcaagcta tcctcccacc tcagcctctc aagtagctag gaccacaggt gcataccacc 107640atgcccagct aatttaaagt ttttttttgt ttgtttgttt gtttgtttgc agagatgggg 107700tctccttata ttacccaggc tggtctagaa ctcctaggtt caagcaatcc ccccacctcg 107760gccttccaac atgctgggat tacaggcatg agccactgca cccaggtcct ccctccttat 107820aaaggtcgcc aagcacaatc ttgtgagcct ggccctatcc acacccatac gcaacatggt 107880gtgtattttt caaacaaaaa ctgaatgaac acctctggtt tgggttcccc tcacacttgt 107940cccgggtttg ttgactctgt gttgtgggcc tagacaaagc agtgtctgga gctcctagac 108000ccagggacca gacagtctgg gttcaaatcc tggctcttcc acttctgcct gagtgctctc 108060tctgaacctg tctttcttta tctataaaat ggagataatt tttttaaact catcacttgg 108120tcaaactgct ttgagcatgc aaatgagttc atatgtataa acctcttaga atgtcccagg 108180caaagaacaa cacttcactc agatcaacat ttatttagca tctactgtgt acccatgact 108240attctaggtg atgaggagac cctctggttc ttatgaggta gtgaggtggg ggagggtgag 108300aaccctaaac attaacgatg gtgtgttcgc aggtgggaaa atcagtaaag tcgggtaaag 108360ggaatttggg agtgctgtgc tcaagtcctg gccctgccac tttctggggt gcaagataca 108420gcattgaata gggtggtcag ggtaggcctt attgggaaag tgatatttga gcagacgatc 108480tagatgtcgg cacatattgc tactgtttga tggtactaat atgagtttga gtttcacttg 108540caagtatata tatatatata tatatatata tatatatata tatatatgtg tgtgtgtgtg 108600tgtatatata tatgtgtata tatatgtata tatatgtgtg tatatatgta tatatatatg 108660tgtgtatata tgtatatata tgtatatata tgtatatata tgtgtgtata tatatgtgta 108720tatatatgta tatatatata tgaaatttgg tccatttatt tatgctgatc aattaattga 108780tgttgaaatt ataattgaat gttttattaa taaacagata cccacatact attttttcag 108840aaattgttag gttttggggt tttctttaga ttttgattat ttttatttgc ttaattttct 108900tttttctttt ttttaatttt atttttccat aagttattgg ggtacaggtg gtatttggtt 108960gcatgagtaa gttcttcagt ggagatttgt gagaacctgg tgcacccatc acccgggcag 109020tatacactgc accatatttg ttgtctgtta tccagtgctc acctcctact cttcccccca 109080agtctctaaa gtccattgta ccattatttt actcacccac attctttggc ctgagatgct 109140gagtggtcat gactcccaga tcccttcttg tttctgtatc aaagatcttt actaagatcc 109200tggcctaggg aacctattcc ctttcctcat ccccaatggg agaaggggct tcttccccag 109260cttatttgcc aactcatagg aaaggtatga aggagaggac tgtagttgtc ttgaagctgg 109320tcagatgttg aagagatgat aatatttgct gatcaagaga gacaaagcaa tgctggaaga 109380agaggctgtg ttagttaaca ccagctgcaa taaccaataa aaccaaaaat ctctggctta 109440agagtatgca tgagtgagaa atcaacttct aaagtacaac tggtggccgg atgtggtggc 109500ttatgcctgt aattctagca ctttgggagg ctgtggtggg agggtcgctt gaccccagta 109560gtttaacgcc aacctgggca acacagtgag acaccatctc tactaaaaat aaaaaataat 109620aaagtgaaac tggtgagggg tgcaatgagg tggagtggtg ggtgactcaa atatggctcg 109680actccatgca gtcactcagg gatccaggct gttggaggct ctccctgctt aaacatgtgg 109740cttccaaggt tgttctaaga gcctacattg agacagcagc tggggaaaag ggaaagtgga 109800gtgggaggta cttatgaggg ttcctggaag tggtgaacaa cacttctgcc tgcattctat 109860tgggtggaat ttagtcatgt ggcccaggct agctgcatgg gaggctggga aatgtagtct 109920ctgattaggc tgccatttcc cagtcccact tgtgaatctt tagtgggaag ctcaccatgt 109980ttgcaccagg gattcagtct acctcccact catgcctcaa ctatgtatca ggcactgtcg 110040taagtacttt acatatcagc ctacctaatg caaacaacta ctcagtgggt gctttattgg 110100tcacatgtat tagtgagaac atggaaaccc agagccgtta aatatcttgc ccaaggtcac 110160acagctagga agtggcagag ttggaatttg aatccaggaa atctggctgc agagccccac 110220gcttagtata aattcattgt agtttagaaa gaggcagaag gaccctaaaa ttggcataat 110280ccattttttg gtccctaagg aactgactga attgactact tgtaaaagtg agtcctggac 110340aggcaacagt ggctcaggtc tgtaattcca ggactttggg aggctgaggc gggcagatca 110400cctgaggtca ggatttcaag accagcctgg ccaacatggc aaaaccctgt ctctaaaaaa 110460atagaaaaat tagctgggtg tggcggtggg tgcctgtaat tccagctact caggaggctg 110520aggcaggaga atcgtttgaa cctgggaggt ggaggttgca gtgagcaaag atcacgccac 110580tttactccaa cttgaatgac agagcaagac tctgcctcag gaccgccatg gccccctggg 110640ttctaggtca gagtttctcc gccacagcac tgatgacttt gggggctgca ttattagctc 110700caaaatggga gctatcctgt gcactgcctc aacttacttg atgccagtag cgcccgcgcc 110760ccagttgtga gaaccaaaaa tgtctccaca cattgccaaa tgtcccctgg gaggtgaaat 110820cacccctggt tgagagtcac tgttctagat tgttaaatat tatcttacac tctagcacaa 110880gtccaaggca aactgactta gaaattacca accttgcaaa aaatagaaga tttcttaaag 110940tcagtgagca tgatggtggc aagctgctga aatcacaccc ccagacatta gcagatggga 111000tctggacagt attcatctag ttaaaaattg acaaggactg ggacactgca ggctcttcaa 111060aagagaatca tttgaataac aaggggtcaa gacaggggta attggtgaaa gcccctgctc 111120ataatttgaa aatataaata ggcatcatga aaattcatcc tgcaaaagtc aaaagtcgaa 111180tgtgcagtgt tatacatgat cagttgattt gggaggggaa attgcatgca cacacatgag 111240agcttgcaca cccacacaca cacacctgtt caagtgtgtg tgccagtgct cagtgaggac 111300catctcccca acctgtctga tcatcttgct ttggggtgac cctatgggtg aggcagaaat 111360tcttggatca tagttttcta atgaatatta taattgttaa cttctgatgg gtgctgactt 111420tttcatcttt gcaacactgc gtaggtattt ttactctccc cattttacag atgagacaac 111480tgaggctcag aaagattgat tagctctaca cgaagccagg atccaggctt agcctggctc 111540caggaatcat gttttgagtt acgtagcttc cctgattctg agggacctcc ccacttctga 111600aatcttctac tgttactccc catggccctt tcctattgac cggaggcacc ccagctcctc 111660actcgtccct tatcttatga aacatgacca tgatgtctga attcaaagga gagcctgggc 111720tttgtgggga aaacgaagca gaaaaagaaa ggtggaggtt ggtggttgtt tttggcatgg 111780tgaggagcct gtcgttgctt gaggaaagca agaaaggaga ttgctggggc ttggatccat 111840ctctgggtgc ctgtgggtct gtctgtaaaa atgagaactg gtcgtgctca ttagaggatt 111900tgaccgttag gccttgggat agcgatttgg gaactttttt ctgctaagac aaagaataat 111960atggttcagg ttcattttgc tcctgctttc ccaagcccta catctcttct gggctttttt 112020ttttttcctt ttctctcctt cttcttcttc ttcttcttct tcttctcatt tttggatctg 112080gacttctgct gactcatctc tctgagcaag gaaggaggga ggaagtcaga attgctcatt 112140aaccgttttc tttagtgact cagctgtgat tcacatttta attaatggag gagaaaaacc 112200tgatcagtcc taaggcatct gcccaatcac gcataactcc aggctggtga taataataat 112260acttgaaaaa agtggggtgt cctgaattaa actatggctc attccccaca ttagtcttga 112320ggactccacc aggccctcta agttccaggt ctcaatgggg ctccctgaac cagagcagct 112380agtccaagcc ccgagcagca tttctgcaga gttagtctga ggtcaggaca agaaacagag 112440gctcaagccc tcctgggatc gcaggaggat catgggaatg taatattgtt tcctgagctg 112500gtctttggct ataatcccag gctcaagcct ggcctccctc ccctcggggc ctgaaatttg 112560tcagagccta ttgcaggggc agcttctgtg ctttttgttt gcccagagaa tgagaaaagt 112620ccagataatc atgaccgcta cttcctgagc acttactatg catcaggtgg tgtgctcagc 112680acttctcatg aatgatcacg ttgaatcctc actctgtcca caaaaagaaa gagcttttat 112740ataattctcc aacctcccta tgaggaaact gaggcttggc aattgcccaa tgtagacaat 112800tagtaaataa tcaggcagga tataaaccca accctttccc acctgggagc cagagcttgc 112860atctactata cttctctgct ttccagtcag ctgcaaagaa aaattggaag ctgatagctc 112920attcaacaaa cacttattga acccttccac ctgctcagcc ctgttctaga caccagagat 112980ccatcagtga accaaagagg caaatccatg gtctcatgaa actgacaatt tacctgccca 113040agtgtattag ttactgttta taagttccta ttaagtgtat tagatatgct tgcagctgta 113100acaaagaatc ccaacatgca taagggctca aaacaataaa aatttcgttc ttgcacagat 113160aaagttcaaa aggtgtattc tttttttttt tttcttttgc gacggagttt tgctcttatc 113220ctccaggcat gagtgcaatg gcccagtctc ggctcactgc aacctccacc tcctgggttc 113280aagcattctc ctgactcagc ctccccagta gctggaatta caggtgcccg ccaccacacc 113340tggctaattt tttgtatttt tagtataggt ggggtttcac catgttggtc aggctggtct 113400taaactcctg acctcaggtg acccacctgc ctcggcctcc caaagtgctg ggattacagc 113460cgtgagccac cgtgcctggc caaaaaaaaa atgtattctt aaacagcagg cacctctcct 113520ctaagcagta agtcaggggc ccaggcttgt tccatattgt agctcctcat cttcaaccca 113580tggcttccaa agtctccatg cttcttgata tcaagccaca gaagggaaaa gagcatgaga 113640agggcacagg agaaatgttt ctgggacaga cccagaagta gtccatatga cttccatcta 113700cctcccactg gctagagctt acatggcggc acccacttgc agagctggga aatggagtct 113760aactgagcat ccaggaagga gagacagaca tgagtctttg cgtgggtcct cactgagaat 113820caagctccac attttgatcg atgtcaccag agcgtacatg gcggcgccca cttgcagagc 113880tgggaaacgg agtctaactg agcatccagg aaggagagac agacatcagt ctctgcgtgg 113940gtcctcactg agaatcaagc ttcacatttt gatctgtgtc acctccttgc aagccctacc 114000ttaggacaat tttaagggac attcctatct tcttccaccc ttaggacagt tttaagggac 114060actcctgagt tcttccaccc acctcctctg tttcttgggc ttccagctct caggatttgc 114120ctttgcctta caatggggtg aagcaagaat ctggaagaat gtctctcccc acaatttgaa 114180gtcttatttg aaaaaaagca gtagagcatc cctccctctt gaggtaggga aatctagaat 114240caaatcctgc ttctccagac tttgacctca gaaactgggg ggacttcaag gtcttcaggt 114300gggcagcttt catgaaccat tcattcctcc cacctcatac caatcagggt cctaacagga 114360aaaagaatta acttctagat ggttcaaaag aagaccatgc catgaagaga ctccttaaag 114420agataggaac aggtgagaga aatagataac ggctgtttga ggtcctcaga gagaagccat 114480cgcgagccct acatttcctg gaacccagtg gaggcagagc tgtgcagaag ggactactgt 114540cagaaccagg gagggagcag ggaagcaata ttccaatctc tttccctccc ctcatcttct 114600gccagcgctt cccctcagcc aaaccaaacc ggaaacggag caaagcattc tgggagttgt 114660agtcttcaag ggtccgcctc gagggcacag agcccgctgg agcattgacc tagagggcac 114720acagggaatg actagtttgc accatcatgt gacggactgc acgccctcga ttatgtaatc 114780cactctataa ttcaactgca gagctgcatg gtacagcagg atagccacta gccacacgag 114840gctatttaaa tataaatgta cattcattaa aatttaacca aatgaaaatt ttagccactg 114900agccccattt caaatgctca ttagccacac gtggctcttg gctaccatat tggacagatc 114960agaatagaac atttccatca tcccagaaag ttctaggggc cggcgcagct gtggtgtaac 115020ctgagcccat gcatgttatg gaatggagaa gagagaaaac agcacaagag gcagttttga 115080agggagacag agagctgtgg atcagtaggg aggagactct ctaggcaaag gagcagttga 115140gaagcaagaa agttgagtga gctgctttgc tgcgatggag gcttccctca cggggaagag 115200tagagtcaga aagctttagt tcaagttcag ctctgaaatg aaccaatgag tgttctgaca 115260agacacctgg ccttccggaa ccttggtttt gtagtggcca agggcttgac cctctgaagg 115320ttcactgaaa aaaatcaact cacaaggcat attaattgga gaaaaggcag gcagatttat 115380ttaatgtgtt tgcacgagag ccttcagaat gaagacccaa agctgcaggg gaaattgtcc 115440gttttttaag cttaggttca acaaagtatg gacagcggtg tagaaatatg attgaacaaa 115500aagtgtacaa tgtaaatgct aatagactga gtggggaaac ccaaaaaggg ctgtcttgat 115560tctccttggt ctctctgagc atgcatttct tccgggtatg ggacaagacc ctctctggaa 115620tggagggggg gctctcttgg ttctccttgg tctctctcag catgcattcc ttccgggtat 115680ggggcaggac cctctctgga ataagggggc tgtcttgatt cttcttggtc tctcagagca 115740tgcattcctt ctgggtatgg ggcaggaccc tctctggaat gggatcctta taacctacgg 115800tcaaataacg taagttagat aatttctttt tttttttttt cttttttttg agacagagtc 115860tgattctgtt gcccaggcta gagtacagtg gcacaatctc ggctcactgc agcctctgcc 115920ttctgggttc aaatgattct cctgcctcag cctcccaagt agctgggact acaggtaagc 115980accaccatgc ccagctaatt tttgtatttt ttagtagaga cagggtttca ccatgttggc 116040caggctggtc tcaaactgct gacctcaagt gatccaccac ctgggcctcc caaagtcctg 116100ggatttgtaa tcccagcatg agccactgtg cccagccaga tcatttcttt ttctttttct 116160ttttcttttc tttttttttt tttttttgag atggagtctc actctgttgc ccaggctgga 116220gtgctgtggt gcaaactcag ctcactgcag cctctgcctc ctgggttcaa gcaattctcc 116280tgcctcagcc ttccaagtag ctgggactag aggtgcgcgc caccatgccc agctaatttt 116340tgtattttta gtagagacag tgttttgcca tgttggccag gctggtctta aactcctgac 116400ctcaagtgat ccacccacgt cggcctccca aagtcccggg atttgtaatc ccagcatgag 116460ctaccacagc tggccagata atttttttat aactagtttt tacaaagaaa ggtggaggga 116520aagttagagt aacattttta ggtgttaggg ctgactttgg ggaaaagagg tctggtttct 116580acgacccgcc ttagggaaga gggattctag tttttgtggc tagccccagg ggagaatggg 116640actaagagat agaagggcag gagaaggtca gagaaaaact tttgcttctg tggctgcttc 116700ggagaacttc attttggggt attgttttct gagccccaac agtttgctta tcagtgaagt 116760gggtataggc gcccacctcc cacagtgacg atgctgtgaa cagggctttg gaagagtaga 116820actatgaaat atttgttgtt gccttgtggg gaaatggtcg ttaaagccaa aattgttcaa 116880gagaagaagc aggaagagtt cctttctttc ctgcaggtat cctcttaagc tgagtcttca 116940gaatcccctg acaacgttta atcaacactt tattaaattc accccaaccc tgcttcaaac 117000cttcacctgg tcctcgagat cttccaactg tttcttgatg aagttagcag gcaattgtat 117060ggcgggatca tcatctcatg ttttgttttg tttttttcct ttttaccctc tgactttgag 117120aaatccttgt ccttttactt ttccaaacct gagagcattg cagagaagtt agaattgagc 117180aggacatggg cttaagaccc agcccagcca tgtgctagct gtgtgaactc gaagcagtga 117240ccccacctct ctgacctgga aagtagaggg aatgatagga cccaccaccg ccacacttgt 117300agggtcatca tggggattga ataaaataat gcataagact tggcccacag caagcactca 117360agaaatgtta gctacttcct aaatatattt ttaacctttt attgaatata acatacatac 117420agaaaagcac atgtatcata caagtagagc ttgagtgatt ttcaaaaact gagcccagtc 117480atgtaaccag cgcctagttc aagaaacaga acatagccga gtgaggctga ggcaggagaa 117540tcacttgaat ctgggaggca gaggttgcag tgagcagaga tcatgctatc gctccccagc 117600gtgggcaatg ggggcggagg ggaagagaga gagagagaga gagagagaga ggaaggaggg 117660agggaaggaa ggaaggaagg agggagggag ggagggaagg gaaggaaggg gagagagaga 117720aaaggaaaga aaagaggaag acagaaagag agagagaaag gtaaagaaag aaaaggaaag 117780aaagagaaag aaagaaaaga ggaagacaga gaaagaaaga gaaagctaaa gaaagaaaaa 117840aaggaaggaa ggaaaatagg gagggaagag gaggaggaag aagaagaaga agggggggag 117900ggagggaaca gctgcagctt cgaggaagga aggagggagg gaaggaagga aggaaaggaa 117960ggaaggaaaa aaaaacagca ccaacgttta gaaaccccct tgtgcctctg aggtcaccag 118020taactccatc ctgacttcaa acagtctaga ttagttttgc ttgtttttga actttaagca 118080catggggtca tacagcatgc atgcattgac ttctttccct tgacgttgta tgtgtgagat 118140tcatctgtgc tgttgctgtt catttgttct catcgctgtg tgtgctgaac cacctgttca 118200tttactctac taatggtggg cagtttggtg ctttctactt tggggctatt ccagagaaag 118260ctactttgaa cacactcaga tatgtctgtg ggtgaccact cttcatattt ctatgggaga 118320tattcctagg accggaacat ctgagtcaga gggaggaatt ggtttagctt tggtaggaac 118380tgcctaacaa ttggccgggc acagtggctc atgcctgtaa tcccagcact ttgggaggct 118440gaggggggca aatcacttga gctcaggagt tcgagaccag cctggccaat gtggcaaaac 118500ccctggccaa catggcaaaa ccccgtctcc gcaaaaaaat acaaagatta gccgagcatg 118560gtggcgtgtg cctgtaatct cagctactca ggaaactgag gcaggagaat tgcttgaacc 118620tgggaggcag aggttgcagt gagcagagat tgcactactg tactccagcc tgggtggcag 118680aatacatgaa actccatctc aaaaagaaga aaggaaggaa ggaagggaag gaaggaaagg 118740aaactgccca acagttttcc caagtgtttg ggatggaagg aaggaaggaa ggaaggaaaa 118800gaaactgcct aacagttttc ccaagtggtt ggaccagtta aaactcccac cacctgtgaa 118860tgagagtttg tttttatttt gctcctggag tgcctctcct gtagcaggtt cccactgaat 118920gtctgggaat tcaaatgtaa tgcacttgtt catttcctca agagcttcac tccatcaatt 118980ggattcatcc attggctctc ccatctccac tgacactatg ttctcacctc tatttggaag 119040acatcctgcc tccacctgcc caagtcacat tatcttctca ttccagcctc tcaaggagag 119100ttttctcttt caccacctcc tctagccctg gtgattggca aggtctcgca acagtaccct 119160tcaaaacact catgactgtg aatgcactgg ccttcactaa gtttcccatt cttctctttc 119220tttctttttt cttttctttt cttttttttt gaacagagtt tcactcttgt tgaccaggct 119280cgagtgcagt ggcacaaaca cagctcactg tagcctcaac ctcctgagct caaggtatcg 119340tcctgcctca gcctccttag tagctgggac cacagacatg caacgttgtg cccagctgat 119400tttctttttt ttcttttttt tttttttttt gagacatggt ctcaccctgt caaccaagtg 119460cagtagcatg atcacagctc actgcagcct tgacctcccg ggctcatgcg attctcccac 119520ctcagcctcc cgagtagctg gggctacagg cacaagccac catgcctggc taatttttgt 119580acttcttgta gagaccaggt ttcaccatgt tgcccaggct ggtcttgaac tcttgggctc 119640aagcagtcct cctgcctcag cctcccaaaa tgctgggatt acaggtgtga gccagcacgc 119700ccggccatgg ctaatttctt catttttggt aaagacaggt ctcactttgt tgcctaggct 119760ggtcttgaac tcctggactc aagcaatcct cctgtctcag cctcccaaag tgctaggact 119820accgatgtga gccaccgcac ccggcaattt ccccttcttg acttctccag agctctcatc 119880cctctcgagc tcctgtctct tctagaatca cttacctcac caccttatgg ggtttttgcc 119940tctgttccta ctcctcttta tttaagaaaa cactgtactt taagagggct tcagaaacca 120000cccgaaatag aaacatgtcc ttttgttcaa tcctttactt taaaagacaa ataaaatgaa 120060gaattgctct ccatgtagaa ggttaaggag cttgggagga ccttctgtga gtggggagaa 120120ctttacatta aaggaaaaaa aatgctggag aatagctgtg aacccaggaa gggagaagga 120180cttcctccac tgaacttgta aagcacaaac tctaaggcaa aaaaagacat gattacatga 120240aaactaagat atttgttcaa ataaagatgc aattggggcc aggtgcggtg gctcacgcct 120300gtaatcccag cactttggga ggccgaggca ggcgaatcac gaggtcagga gatcgagacc 120360atcttggtca acatggtgaa accccatctc tactaaaata caaaaaatta gccaggaatg 120420gtgtcacgtg cctgtaatcc cagctacttg ggaggcttag

gcaggggaat tgcttgaacc 120480agggaggtgg aggttgcagt gagctgaaat cacgccactg cactccagtc tagcgacaaa 120540gcaagactcc gtccaaaaaa aaaagatgca atagcaggtg gttcgggaac caaaccttac 120600atccagatgc tggttgtccc atttcctgtg aatccttggg tgagttatca acctctctga 120660gcctcagttt cctcgtcaat aaaatggaga aaatagtatc tacctatgga attgttgtga 120720gttttgaatg agttaatatt tataaatcat ttagaatagg aattagcaca tggtaaatag 120780tggatagaat cataaaaaaa aaattgatca ggggttaact tctaactgct gtttgttata 120840gaggtcccta gcactgtgtg gtcattttaa atttagatga tttagaatta aatgaaattt 120900aaaactcagt tcttcattca cactagccac attttaagtg ctcaaaaccc acaggtgact 120960agtggctacc atatttggca gcacagattg agaacagatt tatcatccag aaagttctgt 121020cagacagtgt tgatcaaggc tacatgaggg tctgggtgca gtggctcaca cctgtaatcc 121080cagtgctttg gaaggccaag gtgggaggat cactggaggc caggggtttg agaccagcct 121140gggaaacaga gagacctcat ctctaccaac attttaagaa ttagccaggc aaagtgttgc 121200atgcctgtag tcccagctac tcaggaggct gagacaggat tgcttgagcc caggaatttg 121260aggctgcagt gaactatgag cgcaccgctg cactccagtc tgggtgacag agtgagacct 121320gtctctaaac ataaaaaata aaaatgtagg tggggcatag tggctcccgc ctgtaatccc 121380agcactttgg gaagccgaga tgggcagatt gtgaggtcag gagatcgaga ccaccctggc 121440taacatggta aaaccgcgtc cgtactaaaa ataaaaaaaa attagccagg catggtggcg 121500catgcctgta gtcccagcta ctcgagaggc tgaggcagga gaattgcttg aacctgggaa 121560gcagaggttg cagtgagctg agattgcgcc actgcactcc ggcctgggcg acagagcgag 121620actctgtctc aaaataaata aataaataaa taataataaa gtaaaaataa aaatgcaaag 121680actacctgag ggaatgtctg caagtcaacc agaataacac agcaacccca ataggaaaac 121740aggccgaaaa tgtgaacagg cggatcaggg aagtgaagtc tgaaaagcta atcagcctat 121800gacatggtac tcaaagtcat ttgtaaccag aaagatggaa atgaaagcag tatctctgta 121860cacctttaat attggggaaa aaatatgtga ataagccaag ggtttccagc gatgcgggca 121920cagaggaaag tcttgcacca ctcaaagggg tgtggcccag ggaggccact ctggagacat 121980atcggtagta ctcagtccag tgaggtccag caccatcagc gcttatgtcc ccaggcatcc 122040atcccaggga cattcttacc aggtctgtta ggggcaggta cgagaatgct tactccagca 122100ccatctatat aaggggagct gaaggccacc tggtgtccct cctggagacc aggaggcggc 122160atgtgacagc ggcacccatg gagcaccaga atgagtgaga gctccagacc gcatatccga 122220cagatactac gggatggggc ttttagaaat atggttgttg ccgggcacgg tggctcatgc 122280gtgtcatccc agcactctgg caggccaagg cgggtggatc acctgaggtc aggagttcga 122340gaccagcctg gccaacatgg tgaaaccctg tctctattaa agatacaaaa attagctgga 122400cgtggtggcg ggtgcctgta atcccaacta ctcgggaggc tgaggcaaga gaatcgcttg 122460aacccaggag gcagaggttg cagtgagccg acatcgtgcc actgcactcc agcctgggtg 122520acaagagcaa aactctgtct caaaaaattt aaaaaacaaa aaataaaaat atggttctgg 122580gtgaaaacag gaaacaacag aatgtgtcta acttcatcct gcttatgtca gttaaaaata 122640gacacactca aaatatcgca cgtgtttttg cgagaatgca ctcctataag gccaaattaa 122700acattctctc agttgtctct gggagggaga agaatgaaag tagggtatag agagatatag 122760gggaattaat gcatgaatga atgaaggtat aaacaagaga caggcgtcat acagaccaaa 122820ggtaaagata tcccgtaacc tgaggagagc aaagaacttg actctgcatt tgaagattca 122880gaaaatgaat ttcagaaata gttttctcgc cagggggtgg ctcacgcctg taaccccacc 122940actttgcgag ggcgaggcag gtggatcact taaggtcagg agttcgagac cagcctggcc 123000aacatgatga aaccctgtct ctactaaaaa tacaaaaatt agccaggcat ggtggcatgt 123060gcctgtaatc ccagctactc aggaggctga ggcaggaaaa tcacttgaac ccgggaggca 123120gaggttgcat tgagctgaga tcacaccatt gcactccagc ctgggtgaca gagcaagact 123180ttgtctcaaa aaaaaaaaaa aaaaaaaaaa aaaaagaaga ggaagaaatc gttttttcaa 123240gaaggggaaa gctgggtgat ttaagaatga acttgaagag gatcactcag tcctcaacct 123300aggagtggca agaatataga ctgtatggga agtggttctg ctccttggta cccatcttag 123360aaatatttgg cctgagtctg taagaggcag gtactttatc taacctgagg ttagggggcc 123420actacatccc catcccctcc cctgctttct aaccatgcta acatcttctc actctcctgt 123480ctcctctcct tctcactccc ctaatctgcc tattcacatt ttgggcctgt tttcctattg 123540gggttgctgt gttattctca ctgatttgca gacattcctc tgtgtcatct ttttaatttt 123600gttttaattt ttagaggcag gatgtcattc tgttgcactg gctgtagtga cgtagctcac 123660tgcagcctca aactcttggg ctcaaactcc tgtcctctgc ctccacttct caactggtaa 123720cctcacttct cttcatgagg tctctccagc cccagggcct ttgcacatgt tcccctctct 123780tctgagtggc atatggtagt tgctcctctg taaatattta ttgacatcct gacttccaac 123840cagcagagaa ttgacctcct tcccatgctc aggctagtga aggcatgagt ttggctgagg 123900tcccagtggg gaaggtgagt ggggtggcag agttaaccag gagcagcatg gtagaatggg 123960taaaaccaga cgtagcacgc aggcaccaca tgttagctgg acaagtagtt taaccccatg 124020ggtctcaatt tccccatcaa tgaaagggag aatagaacaa gtccctggta agcagcataa 124080aatgagctct cagaatgtaa agtaacaagc acacaacctg gaagagaata catttagtga 124140atattggctc ctttaatcag caggttctga tatgacttag ctacaattaa gaaaataaaa 124200atggaggccg ggcgcagtgg ctcatgcctg taatcccagc actttgggag gccaagacgg 124260gtggggtgga tcacctgagg tcaggagttt gagaacaggc tggccaacat ggtgaacccc 124320atctctacta aaaatacaaa aattagccag gcgtggtggc gcacgcctgt agtcccagct 124380actcgggagg ctgaggcagg agaaacattt gaacccagga ggtggaagtt gcagtgagcc 124440cagattgcac cactgaactc cagcctgggc gacagagtga gatttgtctc aaaaacaaaa 124500gaagtctgga ggccaggagg ttggttgcag ggttggttcc ttggctcaac aatgtctcca 124560aagagtcctt ccatctttcc actctaacat cgtcactgta aggacttttt ttaacattta 124620ccactcacag ccccaagacg actgcgtcag ttctttcttt ttttccttca gacagagtcc 124680cgctctgtcg cccaggctgg agtgcagtgg catgatctcg gctcactgca acctctgcct 124740cctgggttca agcgattctc ctgtctcagc ctcccgagta gctgggatta caggtgcctg 124800ccactgcatc cggctaattt tttgtatttt ttttagtaga gatagggttt caccatattg 124860gtcaggctgg tctcaaactc ctgacctcag gtgatgcacc tgcctcggcc tcccaaaggg 124920ctgggattac aggcgtgagc cactgtgccc ggccgatgac tgcctcagtt ctaaggtact 124980tacccagcca tccacgtaga cagacacaaa agcatccggc caaagaagag ggagaggaag 125040ggctgtctct taccatgtga ctcatctcac ggggaaaaaa tccttttcca gaagcaccca 125100gcagattttt cacccagatc ctgttaggcc tacgaatggg tcatgtgaca agtgctctta 125160ttgcaaggaa tcttgggaaa aagagactat taggcatttt ctgcctcttt gatgggaggt 125220gggctctgcc agtaaggcgg gtagtggtgg tggctcttgg atggacaact gtgtcttcca 125280ttcttcttct tctttttttt ttttttttaa gagacaaggt ctcactctgt tgcccaggca 125340gaaatgcagt ggcacaatca cagctcactg ctgcctcgac ctgccaggct caggtgatcc 125400gcccacctta gcctcacgag cagctggagg agtgtaccac catggccggc taatttttat 125460attttttgta gagatggggt ctctttatgt tgcccaggct ggtcttgaac tcctgagctc 125520aaacaatcct cctgcctcag cctcccaaag tgctgggatt acaggcataa gccaccacgc 125580ctggactctc ttctttaaat actgagcctt ccacctcttc tagaatatac tctgttaatt 125640atcaaccaca cttttctaca tttttgcttc attattcatt cagtaaacat ttattgagtg 125700cctactgtat gccaggcaca gctttaggtg ctggagatgc tatgaacaaa acagatgaaa 125760atttctaaaa aataaaataa aaaataaaaa taaattttgc aaagccaggc acagtggctt 125820aggcctatag ttccacctac tcaggagtcc aaggcagtag gatctcatga gactgggagt 125880ttgagtccag cctgggcagc atactaggac tctgtctcta aaaaagaaaa gaaggccggg 125940cgcagtggct cacgcctgta atcccagcac tttgggaggc cgaggcaggt gaatcgcaag 126000gtcaggagtt tgagatcagc ctgaccaaca tggtgaaacc ccgtctctac taaaaatgta 126060aaaattagcc aggcatggtg gcaagtgcct gtaatcccag ctacttggga ggctgaggca 126120ggagaatcgc ttgaacctgg gaagcggagg atgcaataag ccgagatcgt gccactgcac 126180tccagcctgg gcaacagaat gagaccctgt ctcaaaaaaa aaaaaaaaaa gaaagaaaga 126240atagaaaata tctgccctac ggggatggac atgctagaac atcaaagtcc aatggaactt 126300tctgcactga tgaagtatgt atgtatgcac cagccacatg tggcttggga gcacttaaaa 126360cgtgactggt acaagcgaat ttttcattta atttaaatga atttaaatct gtatttaaat 126420agccatgtgt ggctagtggt tactttattg ggcggtgcag ctctctaaag gccaagagat 126480acatcatcaa cttctctccc ttgacccata ttcagttctc tcccaccctg aaaatctcct 126540ctcctaccca ggctcacatt tccagttctt ctcctcttgt tctccctcaa ccatcagccc 126600ccgcaagact gacgtgaccc tgatgccgta tgaaatgcat tcttcatcct ttactcttac 126660tcacctctgt gcggccctgg agaccagtga cctctccttt ctcaaaatac tttatttctg 126720tgtgtttttg ttgttgctat tgtttttggg gggttttctt gagatggagt ttcactctca 126780tcacctaggc tggagtgcag tggtgcgatc tcagcttact gcaacctctg cctcccaggt 126840tcaagcgatt ctcctgcctc agcctcccaa gtagctggga ttacaggctc ccgccaccac 126900ggctggctaa ttttcttgta tttttggtag agacggagtt ttgccatgtt ggccaggctg 126960atctcgaact cctaacctca ggggatccac ctgcctcggc ctttcaaagt gctgagatta 127020caggcatgag ccaccgcacc cagcctcaaa atgcttttga acttgactgt caggtatgcc 127080attctccaca ccagtctcct cccatgtctg tgtcttctcc ctctccactg gggacccttg 127140gctttttcca cttcactcat ctaccctggg ttatctggtc ttccataacc ctgtcctctg 127200ccacacctca cttattcacc caccacaata tttattgagt actcactagg ccatgaaaga 127260tgctatacaa aaaaagcccc tgtcctcgtg gagctgacat tctagaagaa agcatgaata 127320ataaatacga cttaataaac agtacggcca ggcatggtgg ctcacgccta tcatccaaac 127380actaagagac caagatgaga ggatcacttg aatccaggag tttgagacca ccttgggaaa 127440cgtactggga ccctgtctct acaaaaaaaa tattaaaaat tagctggata gggtaatgca 127500tgcctgtagt tccagctact tgggaggaca aggtggaagg attgcttgag cctgagaggt 127560caagtccgca gtgagctgtg actgtgcact gcacgccagc ctgggtgaca gagtgagatc 127620ctgtcttaaa aataaataaa taaacaaaca aacaaacaat ataattccag agagtgaaga 127680ggcaggatct ctttagctag gaagttgagg gatgttctct ctgagaaggc agaatctgag 127740tttcaacctg aagaattcga agaggccagc taggcaaaag atgagagttg aaggaatggg 127800gacggcagag gagacagcca atatagtaat tctcaataaa gcagaaagtg agcttttcct 127860gctggcagaa cagaaaggaa gtcggagtgg ccagggtgtt gtgggacaag gtggtcagca 127920ggagtcacat cacgcaaggt catgtggtca tggtagactt taaattttac tccaagcctg 127980atggaagcca ttggaagatt ttaactaagg agtgacggaa aactggcatc tcaaactcaa 128040catgtctaca acccagttct tgatctttga aaccttcttc ctccatcttc cccatctcca 128100ttgacagcaa cttcatcctt cagttagctc aggccaaaac cctggagtca cccttgatac 128160ctctctcctg ctccacactc agtctttcca ttggaagccc taggggctgc catattgttc 128220tccatagcac ttcacaccgt ctgacatact atatcttttc ccactattgc tttgtccttg 128280gtagcatctt taggcactct ctgaatatct ggcacatagt acgtgctcac taaatccttg 128340ttgaataaat gaatgaacat cactccgtgg tcctttcaga accagagcca ttcttctctt 128400tcttcaccac cgttgcccct caccccgccc aactagtcac aggagttgaa ggatgacaca 128460gtagagaact gggattctgg agtcctgtgg ctggtctggg gttcgagttc ttactcagtg 128520gtaggaacct ccatgtggga ttaacttatc tggtctttag tttcctcctc tgtaaaatgg 128580gcctcaaact gccaaccgct gggatgcagg gaggatttga tgagcccagg caggctccct 128640ggagcacagc aatcaatggc agctatatat aaaccggggc ctcttttgta ctcccactgc 128700ctttgtccta gttccagccc tcattacacc agcctgctct tgcggctccc tcctaacttc 128760tgctccatca ccaccaatct gtcctttcag ctgtcaggct tgtcttctga acgccaaccc 128820taatcacatc ccttcctgct ccaaaacctt acatgactct cactgtccac aggacaagac 128880ccagcctcta gttgacagcc tccactgtcc agcttaccca acctctcccc taccacatac 128940cctgagtgga gccttctgcc tccatagggc tttcttagcc agagaagcct cccttatctt 129000cctgttctcc tcctaattcc ttcttatcct tccagggagg aggctgtgag gtaatgcatc 129060ttgggagcca gctgggattg cacagggtgg tgagattatc tgcatttccg aggcttgaac 129120aagttaaggc aatgggaaag gtcacacaat gagaaaatgc agggccagga tttaacccgt 129180ctgagatgtt ctgactgtgc tatgctgcct ccccggacat gagctctgcg ataatgctgt 129240ccccaggctg taatcattcc ctctttcatc cctgcctcct ctatccctgg ggtcagaggg 129300acttgtagtt gaatctctca ctcactcatt ggtgtggtct ctccctaaag cagggtggag 129360tttgtcttag cgttatcact gcatccagca caacctccct ggtccaggct tatcagcgtt 129420caactgcgtc aatgcagttg cctcctcctc aatctcccag cttccggcct tgccccctag 129480agagatcata ttttaataca agtcagatta catccctcct cccctcagaa ccctccatgg 129540ctcacacctt actcagagaa aaagccaaag tcctctccac aacccacaaa gccctgcacc 129600atccatcacc tcactgcctt cgtcccctca caccctcccc cttgctcgct ctgcttcagc 129660cacaccaact catctctgtt tctcaaatac accaggcatg gcctagctat taaatgcacg 129720gtccagcctg gtgcatttga agaacacgga tgaattggtg tggctggaac agagtgagtg 129780agggggagag cgggaggagg acctttgcac cagctggacc tttgcaccgg ctgttccatt 129840tgcctagagt tttccctgac atattcatat ggctcactct cttgcttccc ttgctttctc 129900ccagtcttta ttcaaatgtc tatttctctg cacttgtgct gtttgataca gtcaccgctg 129960gccacatgtg gcctttgagc acttcagttg aaacacatga aagtgtagaa tattgaccag 130020attccaagga aaaccatgtg caaaatatct tttatctctt aagatacagg gtctcgctct 130080gtcttccagc ctggaatgca gtggcacgat cacagctcac tgcagcctca aaatcccaaa 130140ctcaagtggt cctcccacca acagcctccc gagtagctgg gattacaggc acacaccaca 130200atgccccgcc cattttttta attgttatta ttttttttaa tagcgacaag gtcttgccat 130260gttgctcagg ctggtctgga actcctggcc tcaagcgatc ctcctgcctc agcctcccga 130320gtagctgaga ttacaggcag gagcttttgt gcccagcagg tctacgatct tcttagaatg 130380cttcaggctg ggcatagtgg ctcatgcctc aaataccagc actttgggag gccaaagcag 130440gcagattgct tgagctcagg agttcgagac cagcctgggc aatatggtaa aaccctgtct 130500ctccaaaaaa aatacaaaaa ttagctgggc ttggtggctc ccacctgtag tcccagctac 130560ttaggaggct gaggaaggaa gatcacctga gcccaggagg cggaggttgc agtgagccaa 130620gattgagcca ctgcactcca gcctagacaa cagggagacc ctgtctcaaa ataaataaat 130680aaataaataa ataaataaat aaataaataa acaaacaaac aaacaaacca ataaatgaat 130740tttacctgtt tctttttact tttttaatgt ggctactagc aaattttaat tttttttttt 130800tttttttttt tttttgagac agagtcacgc tctgtcaccc aggctggagt gcagtggtgt 130860gatcttggct cactgcaacc tccacctcat gggttcaagc agttcgcctg cctctgcctc 130920tgagtagctg ggattacaga tgcccaccgc cacgcccagc taattttttg catttttagt 130980agagatggag tttcgccatg ttggccaggc tggtctcgaa ctcctggcct caagtgatct 131040gcctgcgtcg gcctcccaaa gtgctgggat tacaggcatg agccaccgcg cctggctata 131100aaatttcata agtagctctt aatagatttc tcctgggcag tgctggtcta aacacttttt 131160tttttttttt ttttttttga gacggcatct tgctctgtca ccaggctgga gtgcagtggc 131220gcgatctctg ctcactgcat cctctgtcac ccgggttcaa gctattctcc tgccttagcc 131280tcccaagtag ctgggactac agacacccgc caccacgccc agctaatttt tgtattttta 131340gtagagacgg gttttcacca tattggccag gctggtctcg aactcctgac cttgtgatcc 131400gccagccttg gcctcccaaa gtgctgggat tacaggcatg agccaccgca cctggctata 131460aaatttcata agtagctctt aatagatttc tcctgggcag tgctggtcta aacacttttt 131520tttttttttt ttttttttga gacggcatct tgctctgtca ccaggctgga gtgcagtggc 131580gcgatctctg ctcactgcat cctctgtcac ccgggttcaa gctattctcc tgccttagcc 131640tcccaagtag ctgggactac agacacccgc caccacgccc agctaatttt tgtattttta 131700gtagagacgg gttttcacca tattggccag gctggtctcg aactcctgac cttgtgatcc 131760gccagccttg gcctcccaaa gtgttgggat tacaggtgtg agccaccgcg cccggccctg 131820taacactttt aacactgaac tgtttgcctt ccaggtggta aagagcaggt gcctttactg 131880atagaaatgt caccactccc ttcatcccgc cagccccatg tcactgacgc gtcctttccc 131940cttgctctgt ggtaactttc tcctaagcac tcatcgccct aacatctgtc atacaggtat 132000acctcagaga cactgctggt ttggttccag gtcgccataa caaagcgaat attgcaataa 132060agggagtcgt gccttttttg gtttcccagt gcacataaaa gttatgctta cactatagtc 132120tgttaagtgc atgatagcat tatgtctaaa aaaaaatgta cataccttaa ttttaaaatc 132180catcaaggct gagcacagtg gcttgtaatc ccaacacttt gggaggccaa ggcaggagga 132240ttgcttgagc ccagggattt gaaaccaggc aacaaagtga gaccccgttt ctacaaaaaa 132300attcttttta aaaatagctg ggtatggtga cgcatgcctg tggtcccagc tacatgagag 132360gctgaggtgg gaggctcact tgagcctgag agattgagac tgcagtgagc tgtgatcaca 132420ccactgcact ctagcctggg ggacagagtg agaccgtatc tctcaacaaa aattaaaaaa 132480aaaaaaaaaa aaggctgggc acagtggctc atgcctgtaa tcccaacagt ttgtgaggcc 132540aaggtgggtg gatcacttga ggtcaggagt tcaaaaccag cccagccaac atggtgaaac 132600cccgtctcta tgaaaaatac aaaaaaatag ccgggtgtgg tggtgcacac ctataagccc 132660agctactcgg gaggctgagg cacgagaatt gcttgaacct gggaggcggg ggggagattg 132720cagtgagccg agattgcact gctgcactcc agcctgggtg acagactgag actctgtctc 132780aaaaaataaa taaataaata aataaataaa taaatgtttt attactaaaa aagttaacaa 132840tcatctgagc cttcagtgag tcctcatctt gctggtgaag ggtcactggc tcagtgttga 132900tgggtgctga ctgatcgtgg gggtggttgc tgaagattgg ggtgcctgtg acattttctt 132960aaaataagac aagaaagttt tccgcatcca tcgactcttc ctttcacgaa agatttctct 133020agcatgagat gcttgttgac agcaatttta cccacagtag aacttttttc aaaattggag 133080tcagttcttt caaaccctgc cactgctttg tcaactaagt ttatgtcata ttctaaatct 133140catgttgtca ttttaacagt gttcacagaa ttttcaccag gagtagaatc catctcaaga 133200aatcactttc tttgctcttc cataacaagt aacgcctcat gcattgaagt ttgatcatga 133260ggctgcagca attcagtcac atcttcaggc tccacttcta actctagttc tcttgctagt 133320tccatcactt ctgcagtgtc ttcctccagt gaagtcttga actcctcaaa gtcatccatg 133380aggatcggaa ttgacttcct caaaattcct attaatgttg atattttgac ctgttcccac 133440gaatcacaaa tgttcttttt gttgtttgtt tgttgtggat tgttttttta tttttaattg 133500agttgaggtc tcactatgtt gcccagactg gtcttgaact cttggcctca agtgatcctc 133560ctgccttgat ctccctaagt gctgggatta caggcatgag ccactggaac agccacaaat 133620gttcctaatg gtatctagaa tggtgaatgc ttttcagaaa gttttcaatt tcctttgccc 133680agatgcatca aaggaattta tctatggcag ctatagcctt atgaaatgta tcccttaaat 133740cataagactt gaaatagaga attacttctt gatccatggg ctacagaatg aatgttgtgg 133800ctgggcatgg tggctcacac ctgtaatccc agcactttgg gaggctgagg caggtgggta 133860acttgaggtc aggagttcaa gaccagcctg gtcaatatgg tgaaacccca tcactactaa 133920aaatacaaaa attagctggg catggtggcg tatgactgta atcccagcca cttgggaggc 133980tgaggcagga gaattgcttg aaccctcttg aagacagagg ttgcagtgag ccaagatcac 134040accactgcag cgacagagtg agactctgtc tcaaaaaaaa aaaaaaatgt tgtgttagaa 134100gtcataaaaa caacattcat cttcttgtac atgcccatta gaggtcctgg ataaccagtg 134160cattgtcagc agtaatattt tgaaagaaat cttttttctg gctgggtaca gtggctcgca 134220cctgtaatcc caccactttg ggaggccgag gcgtgtggat cacctgaggt cgggagttca 134280agaccagcct ggccaacatg gtgaaacccc aactctacta aaaatacaaa aaaattagcc 134340aggcatggta gcaggtgcct gtaatcccag ctaccctgga ggctgaggca ggagaatcgc 134400ttgaacctgg gagtcagagg ttgcagtgag ctgaggtcgt gccattgcac tccagcctgg 134460gcaacaagag tgcgacttca tctaaaatac atatatatat ataacatgtt atatgtaata 134520taaattatat atataacata tatgtaatat aaattatata tcacatataa catatatcat 134580gtgttatata tatcacatat aacatatgtg ttatatatca catataacat gtgttatata 134640tcacacataa catatattat gtgtatatat gtcacatata ttatgtgtta tatatgtcac 134700atataacata ttgtgttata tatatcatat ataacatata ttatgtgtag tgtatcatat 134760gtaacatata ttatgtgtag tgtatcatat ataacatata ttatgtgtag tgtatcatat 134820ataacatatg tgtagtgtgt tatatataac atatattatg tgttatatat ctcatatgtt 134880atatataaca tatattatgt gttatatatt atatatatat ttttttctga gtagatctca 134940acagtgggct taaaatatca gttatccatg ctataaacag acgggctgtc attcagtctt 135000cattgttcca tttatagagc acaggcagag tagattcagc ataattctta agaccttagg 135060actttaggaa tggtaagtga gcattggttt caacttaaag tcaccaggag cactagctcc 135120taacaagaga gtcagcctgt cctttgaagc tttgaagcca ggcattgact tctcctctct 135180agctatgaaa gtcctagatg gcaacttctt ccaatagggc atttcatcta cattaaaaat 135240ctattattca gtgttgccag cttcattaat aatctcagct agatcttctg gataacttac 135300tgcagcttct ccatcagcac ttatcacttc accttgcact tttatattat ggggacacct 135360tctttcctta aacctcatga accaagatct tctagcttca gatttttctt ctgcacttcc 135420ccacctctct cagtcttgct gtgggcttgc tgtggattag gctttggctt aagggaatgt 135480tgtggctggt ttgatcttct atccagacca ctaaaacttt

ctccatgtca gcaagaagcc 135540tgtcttactt tcttatcatt catgtgttta ctagagtagc ccttttaatt tccttcagta 135600atttttcctt tgcattcaca acttggctaa cctctagctt atggcctttt gtttgtttgt 135660ttgttttgtt tttgagacag ggtctcactc cgttgcccag gctggagtgc agtggtgcaa 135720tcaccgctca ctgcagcctt gacttcctgg gaccaagtga tcctcccacc tcagcctcct 135780aagtagctga gaccacaggt gtgcaccacc acacccagct aattttttta ttttctgtag 135840agatagggtc tccctatttt gcccaagcta gtctcaaact cctaggctca agccatcctc 135900tcacctcagc ctcccaaaat gctcggatta caggcatgag ccaccatccc tggccctatc 135960tcagcttttg acacgccttc ctcactgtgt ttaatcattt ctagctttta atttaaagtg 136020agagacgtgc aactcttctt ttcacttgag cacttaaagg ccattgtaca gttatacact 136080gacctaattt caatattgtt atgtctcggg gaataggaag gcccaaggaa agcgggagag 136140atggggaaat ggccagttgg tagagcagtc agaacacaca caatatttat cgatcaagtt 136200tgccatcttc tatggatgtg gttcgtggca cccccaaaca atgactatag tcacatcaaa 136260gatcactgat cacagaccac cataacagat gtaataatta tgtaaaagtt tgaaataccg 136320taagaattac cagagtgtga cacagagacg caaagtgagc acacgctgtt ggaaaaaaaa 136380tggccctgat agacctcctt gacacagggt tgccacaaat cttcaatttg taagaaacac 136440aatatctaca aattgcaata aagcaaagca caatgaaatg aagtcttcct cggccggtgt 136500ggtggctcac gtccataatc ccagcacttt gggaggccaa ggcaagagga tcccttgagc 136560ccaggagttg gaggccagcc tgggcaacac agggagactc catctctaga acaaaacaaa 136620acaaagcctg cttatattta ttgggtttac tctcagtctc ccccacacag agatagggcc 136680tggcttgtta ttagtgctca gttgatgttt gtgaagtgaa atactaagga cttaaccact 136740gcctgttctt tgctgttcat gccctgacag cttttatgtg ccagcacaga agaaaacaag 136800gtgcaagaag agaatagtga tctctaagtc agaatttgag gaacccaaat tagtaccaga 136860aagctgggag gagaagagaa aaataaagta aatcaaatta aaagttgaat gggccaagtg 136920cagtagctca tacctataat cccagcactt tgggaggctg aggtgagagg atcacttgag 136980gccaggagtt ctagaccagc ctgggcaata tagcaagacc ccatctctac aaaaaaaatt 137040ttttaatttt ctgaatatgt tgttgtacac ctgtagtccc agctgcttag gaggcagagg 137100tgggaggatc gcttgagccc aggaggttga ggctgcagtg agctgttgtt gcaccactat 137160actcaagcct gggtgacaga ataagtccct gtctccaaaa ataaaaataa ataaattcat 137220tttttgtaaa gttgtatgtc atggcccctg cctactctgg cttcatgact tgctgcttga 137280acctcaccat ccaaatccca gtggtgacac catgtcattt cttgaatttg ccaagccctc 137340tttcagtccc aagctctctg tcatggccac tctcagcctg gaaagttctt tccccactgg 137400ccagatttct ccccctcatc tatgggaact tgacttgaag tagggggtat cccaggccct 137460ggactagtta acacgacctg ctgtgtgccc ctcaaagcca ttgtcttcct agctgagaag 137520gcatcacacc tgcaacagat tcactcattg tgtgcatgtt tttcttaacc acttctcttc 137580tgcatcagct ccatggggca gggatagtct catatgtcac tctacccagc acataggata 137640cgctcagacg cccacttgtg gatggtggaa aaggtcagcc caacctaata tgcccatctc 137700tcctctaggg gtaatcttga gaaaaaaagt tgggaacttg ctttgtgtta gtttaggatg 137760acccagaata gatcctgaaa caagaattta gggcaatcct tgtgcaagta gttcatctga 137820gaggtgaccc cagaagggtt ggagaaggag aggggaggtg gggcaaggaa gggtgagttg 137880tcctgtaggc aactgagctc cgtcctactg ggagcccacg tggaactcac ctcttaagtg 137940atccagaatg aagggtgagg gagctgcggt attgatccac caactcccag caatctttgg 138000ttgagggctg ctcccttaaa gttcattccc tgggcctgcc ccagatttgg agacagccct 138060aaggcaagag gtacagatac cagttggcca cagactgaag tgttaagacc caagcccctg 138120gataaaactg aaaaatcaag ccagatgtgg tggttcccac ctgtaatccc agctactcag 138180taggctaagg caggaggatt gcttgagccc aggagttcaa tgctgtagcg agctatgatt 138240gcaccactgc attccagcct gggcatcaga gcaagacccc atgtctaaaa taaaaataaa 138300ctgaaaaatc cccaagttat ttgctgtgac caaccttcca ttaaccacag accctctggt 138360attcagcatt tcttgtccat tatatgaagt tctgatgaca gtctctttta ttgtattgtg 138420ccttgaccac gcactgtaca tcacttagct ctgaaatgga catgttcagg aaacagggcc 138480aggtgggacc ctgtgtttca acagcaatac ttttacaaat gaggtctcat gacagggtct 138540tgctcggagg gtttctatgg aagcctcatc ccacctactg ctatcatcct tactaacttg 138600catttacaaa agggactctt tttgaccaga ggcttggggt ctgtagctgc cttctagcca 138660gctgatgctg gctggtccac acaagcagga tcacacccat ttttttgttt tcttatttat 138720ttctgaatag gttagcatac cggtaacctg tgtgcctggc attgtgctga ccactttttg 138780tcaacttact gaatcctcac aacccttgga ggtattgata ctattgttat ccaggttata 138840caaaaggggg aaactgaggc acagagcagg gatgtccctt gcccaaggtt acccaactgg 138900aaagtggcag atctgggatc tgaacccatg caggctgggc tcttaacact gaactacttt 138960cctgccattt gttaaagagc cacaaaccag gccaggcacc atggctcacg cctgtaatcc 139020cagcactttg ggaggccgag gcgggtggat cacctgaggt caggagttca agaccagcct 139080ggccaacatg gtgaaaccct gtctctacaa aaatacaaaa aaaagtaccc gggcatgatg 139140gcgggtgcgt agtaatccca gctactcggg aggctgaggc aggagaatcc cttgaacccg 139200ggaggcagag gttgcagtga gctgagatca caccattgga gatcgcactc cagcctgggc 139260aacagagtga gactctgtct caaaaaaata aaataaaata aaataaagag ccacaaaccc 139320cgaaaggtct gccattcccc cagggcccca ggccacccca caatctattg tcattgtagg 139380ttgtgaaata tactgaatgt caccccaacc ttgagccatg gggaagattc catttctctc 139440attgcaacat ttgtgcaaca tgaaccatct gttgggggtc ttcgtaaatc accttttatc 139500ccgtgaggca ggtactgtta agaccatttt acaggtgaca aaactgaggc cagtggtgtc 139560gagtcacctg cctgtggtca cccaaccaat acaggacagc ttggaatccc aagcaccccc 139620gccctgctgt ctgaccccca aaacccaccc tctgttctcc attctggctt ctttctttca 139680gcatcttggc gacagttggg acggagtttg acctacggac gctgagggca gttcgagtgc 139740tgcggccgct caagctggtg tctggaatcc caagtgcgtg agtttccgac cctgacaagg 139800ggtttgctca cgggccccag gagccctcag tttcccctat gcagagcatc tcaggaggcc 139860acatcctgcc accagcctgt gtgagggcag tctcttcttt gggactccct atagggaacc 139920ccctaggaat atgactgtag ctccccatga gctcctgaaa gcaaactagg agccacaccc 139980atttattgag cacctactgt ctatcgggag ccatgctaag caccacgtgt gatctcattc 140040agtactcaca gccctatgaa gttgatagga ctgatgtctc tattttatgg agggggaaac 140100tgaggctcag agtggctgaa acattggagc agggttttgt ggctgagaag tggcagaact 140160aggagtgagc aagtgtgact ccaagcctgg gccgtaccac tggtggcaat gaccattccc 140220atttaatgag tgcctgctgc gtgcagggca ctacagaagg actttacatg aattacctta 140280tttcatcctc acagtcaccc agcgaacacc cattttacag atgagacggt tgaggcttaa 140340ggaggttaaa ttactcacct gaattcttag agtggacagt aatgagctct aaaattcata 140400ctcattcctt gctgctttct cattctccac agatacatct agtccccgtt taagggtggc 140460tgccatatgc agggtcaaga ttaagtgtag gttgagccaa aaaaaaatgt aaaaagcaaa 140520aataaaacag ggctgtcctt tttctatctt cttgtcttgg ttaataataa taatttagcc 140580aggcatggtg gctcatgcct gtaattccag cactttggga ggatcacttg aggccacaag 140640ttcgagacca gcctgggcaa cattgtgagg aacaccaccc ccaccccccc gccaatatct 140700acaaattttt tttttttttt tagaaattag ccaggttgac tgggcacagt ggctcacacc 140760tggaatccca gcactttggg agaccgaagc gggcagatag agcgagctca ggagttttaa 140820gaccagcctg ggcaacatgg cgaaaccctg tctcaaaaaa aaaaaaaaat tagcaggcat 140880gatggtgcac acctgtagtc ccagctactt aaaaggctga ggcaggagga tctgagccca 140940ggaggtcaag gctgcagtga gctgtgatag caccactgca ctccagcctg gacaacagag 141000tgagaccttg tctcaaaaaa acagacaaca aaaagtttaa aaacaaacaa tttataggct 141060gggtgcagtg gctcatgcct ataatcctag cactttggga ggccaaggtg gatgggtgga 141120tcacctgagg tcaggagttc gagacctgcc tggccaaaat ggggaaaccc cgtctctact 141180aaaaatacaa aacttagccg ggcgtggtgg cgggcatcta taatcccagc tactcgggag 141240gctgaggcag gagaatcact tgaacccggg gggcggaggt tgcagtgagc tgaaatcacg 141300ccactgcact ccagcctgga tgaaagagtg aaactccgtc tcaaaaaaag aaaaaaaaaa 141360attaaaaagc acttactatg tgccagacat tattctaagt atttccattt ttttaaagtc 141420ctttatcctc ccaacaagcc tgtgaagtag tctcttttat tatcaccatt ttacatttta 141480ttggcttcgt tcttccggtt cattgctacc caggtttaaa gagtaagatt tcccagagga 141540tcaccagcag gatctttttg tagaaagaag acacttctat ccaaggtctc tgcaagatcc 141600cagcagatgc ctgcatcata ttaaattaag ggccatccca aatctaatag tcaaaagagc 141660caggtgcagt ggctcacacc tgtaatccca gcactttggg aggccaaggc aggacgattg 141720cctgaggcta ggagttcaac accagcctgg gcaacaaagt gtgaccctgt ctcaaaaaat 141780atatgtatat tataatagca gtagtaacaa gagtctctgt ttaatgacca cctatgactt 141840accaggtact tcactgtgtg tgaactctct catctaatcg tatgagggag gtactattgc 141900agtccccatt tacagatgga gaagctgagg tttggaattc actagtaagt ggatgactag 141960gtcaggttcc cttgaagcgg atacttaggt gggtgttcag atgcacctgc tttattgggg 142020gacggctctt gggagagaca gcaggagatc agcagggtgg ggctggggaa tggatagagc 142080agggacgcaa tttcagctgg agtgtgtgtg acaccagagt tgtcctccaa tgcatggcaa 142140ggatgccggc cttttgtact tctatagtca gtcactgtgg atgggaggta gagacgcagt 142200agctcccagg tgagatagct tttgatcacc aagggcaatt ctactaagaa gagaggcagc 142260tgggaggcat tagcaaccaa catccatagc agctggaggg cgggtacacc agaaagaaaa 142320tgggatcttg gccagacacc aagagtatcc agcaccttaa ccactgcacc acactgcatc 142380tgttagcacc cacattacat tttttttttt tttttttttt tttgagacgg agtctcgctc 142440tgtcgcccag gctggagtgc agtggcgaga tctcggctca ctgcaagctc cgcctcccgg 142500gttcacgcca ttctcctgcc tcagcctccc gagtagctgg gactacaggc gcccgctacc 142560acgcccggct aattttttgt atttttagta gagacggggt ttcaccgtgt tagccaggat 142620ggtctcgatc tcctgacctc gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac 142680aggcgtgagc caccgcgccc ggccagcacc cacattacat ttttaagccc ttggagtggc 142740atggcccctc gagctatcct gacagcttcc ctctcttact gtggtctcca cccatcaaga 142800gccatgggaa gttcctgcaa tcaagaagca aagcctcagg ctatatgttt gaaccttcat 142860tttgatcata gactttccta gtagatacca tagtggttac aaacatagga tgttgtcatc 142920gttcagacct gagttaatag cctcaagaaa aaaatggtag tggaaccagg tatggtgaag 142980tgtgcctgta gtcccaccta ctcgggaggc tgaggcagga ggctcgcttg tgcccaggag 143040gtcaaggctg cagtgagccg tgatcatgcc actgtattcc agcctgggtg acagagcaag 143100cccatctcaa aaaaaaaaaa aagccaatga taggcagaga aatactaact aaggctcttg 143160ctctgtcgcc aggctggagt gcagtggtgc aatcacagct cagtacagcc tcaacctccc 143220cagactcaag caatcctacc atctcagcct cccaaatagc tgggactcca ggcacacagc 143280accatgccca gttaattttt ttgtattttg tagagacagg gtttcaccac gctgctcagg 143340ctggtctcaa actcctgagt tcaagtgatc cacccgcctc agcctcccaa agtgctggga 143400ttacaggtgt gagccaccac gcttggccag ctattattat tattaacatt cttcgagtct 143460tacaacagtg gaacttttag tgcaggatgc gaatttcagt attaacccct tcctctccca 143520aaaggatttg aagcccagag taattcagcc gccatgaatg aaccatttgt tagatgagag 143580gctactggag gctgagcttg gtaggataag agcttgcatg gggtccctga ttgatgacaa 143640tacccccaga tttaggtctt cagatgccca gttgggtgtg tcttctgttc cactgtgtcc 143700cttcggggac tgttccctgc cttctttctt tttgagatgg aatctcgcac tttcacccag 143760gctggagtgc aatggcgtga tctcagctca ctgcaagctc cacctcccgg gttcacacca 143820ttctcctgcc tcagcctccc gagtagccag gactacaggt gcccgccacc acgcccagct 143880aatttttttg tatttttagt agagacgggg tttcaccata ttagccagga tggtctcgat 143940ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta caggcgtgag 144000ccaccacacc tggccccctg ccttcttatt caccaccatc tttctgaatt gggttgctca 144060gaacagagaa agcaacatca gcacatgggc aaacatgggg cttcatttca gatggacctg 144120ggttcaaatc ctagttctgc cttttttttt tttttttttt ttttttgaga cagagtcttg 144180ctctgtcacc cagactggag tacagtggcg tcatcttggc tcactgcaac ctctgcctcc 144240caagttcaag caattctcct tcctcagcct cccaagtagc tgggattaca ggcgctggcc 144300accatgccca gataattttt tgtattttta gtagagatgg ggtttcacca tgttggccag 144360acttgtcttg aactcctgac ctcgttaatc cgctggcctc ggcttcccaa agtgctggga 144420ttagaggcgt gaaccgccgc cgcgccctgc ctagttctgc catttctcat gcattctctg 144480ggtgaatcac agcatctctg ttagccttgc ttcccacttc tgtaaaatga gagtgacttt 144540acatgtatgg ccacctcagg ggcttgtcac tagaagccag tgaaataatg ttgagtctgg 144600ttccttgggg ttgaaattgg gaccgccaac cgctttccta cccagagcag caactagcct 144660atatggcggc cttttatgaa tgaggaaaag acaccgcctc ttggcagaaa aaaaaaatta 144720agaaaatggc tccctcttct gggtgcaagt tgcccaacac ccaggaatat ggctccaaaa 144780gcaatggact cccacccctt tcttgcccaa aagatcatca aatggaacag catgtcaaat 144840acctttatta agtactttaa agttggctgg gctctgtggc tcatgcctgt aatcccagaa 144900ctttgggagg cagaggctgg aagatcgctt gaggtcagga gttcgagacc agcctggata 144960acatagtgag accctgtctc tataaaatat atatatagat ttatttgaga cagcgtcttg 145020ctctgccact caggctgggg cgcagtggca caatcatagc tcactgcagc cttaacgatc 145080ctcctgcctc agtccctaga gtagctagga ctacaggcat gcaccatcat gcctggctaa 145140ttaaaataaa taaataaata aatactttaa agttaaaagt gctttttaaa aaataataag 145200gccaggcgtg gagactcacg tctgtaatcc cagaactttg gaagaccgag gcgggtggat 145260cacgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccctgt ctccactaaa 145320aatatgaaaa attagctggg cctactcggg aggctgaggc aggagaatgg cgtaaacctg 145380ggaggcggag cttgcagtga gccgagatgg caccactgca ctccagcctg ggcgatataa 145440caagactctg tctcaaaaaa aataaataaa ataaataata ataataatag gggccaggta 145500tggtggctca cacctataat cctagcactt taggaggctg aggagtttga gtccttggag 145560accaggggtt tcaggccagc ctgggcaaca tagcaagacc ccatctctac aaacaagttt 145620taaaacttag ccaggcatgg tggtgcatgc ctgtagtcct agctattgca gggactgagg 145680caggaggatc acctgagccc aggaggttga ggctgcagtg agctgtgatt gtgccactgc 145740actccagcct gggcagcagt gcaaaaccct gtctcaaagg aaaaaaaaaa cctaggaagt 145800gttgttccca tgataaggat cagcctccgt gtggtgcttc cttcaccatt gcccaatccc 145860caggctcctg ggtgcttaat attccctcag gaacacacct gctttgtctg ggagagacct 145920gggcgtcttg gtggcggggt ttgggggtac ttgctcatgg gcttatgggg cctctctctg 145980tgtcccccca ggtttacaag tcgtcctgaa gtcgatcatg aaggcgatga tccctttgct 146040gcagatcggc ctcctcctat tttttgcaat ccttattttt gcaatcatag ggttagaatt 146100ttatatggga aaatttcata ccacctgctt tgaagagggg acaggtaggt ccacggagca 146160tgatgcatct ttccagtttt ctccttcagg gacaagctct tgggaggatt aggcaggggt 146220gtgcttcttt ctcctggcag ctgggaggac cgtctccttc agagagcact acaggagagg 146280cagtgagtga aatagcctct gagatcttag ctgttgaaag gggtggggtt ccacagaagg 146340tgacccagca gagaaagagt ttatttggga atgatcccag gaagcaccat cgggggaatg 146400aggaagtgag cagagaaaga agggatcttt taaagagtgt gctatcaagc gggttaccac 146460ttaaaactgg gactggatcc ccctgggcac ctctgggaga cagcaaagaa cacacaactc 146520agctggtcac ggtggctcac gcctgtaatc ccagcacttt ggggggccaa ggcgggtgga 146580tcacctgaga tcaggagtca gagaccatcc tggccaacat ggtgaaaccc catctgtact 146640aaaaaataca aaaattagct gggtgtggtg gcaggcacct gtagtcccaa ttactcagga 146700ggctgaggca ggagaatcac ttgaacccgg gaggcagaag ttgcagtgag ccaagatcac 146760accactgcac tccagcctgg cgaaagagtg agactccatc tcaaataaat aaataaataa 146820aaatataaat aaaaaaagaa cacacacctc agagccgtcc cagccaaggg gcaagggagc 146880tggggtattt atacactggc ttctttttga cattggtgag gactgctcct agagtgggaa 146940ttaatgcctg gcacatctgg ctgagtggaa caggtattct gggtgctttc agacctcgac 147000cagtcctgac ttctaaagca agcaagaagt ggggagagtt gggccagaaa agggttattg 147060cctcaatgca ttgtgagtgg taccttgtgg aaggtgagag acagagaaga ttccaggcac 147120aggtgccatg ctaaacgata gttctcattt attataggaa cccatggatt tattttgttc 147180tctgccctga gtgctgggtg agagtactgg atgagtcctc ctggtctccc ccaaccccca 147240ggatgtacca gagatacccc aattgggagt cctggcacca accaatcaga acctagcact 147300cagcagcatt ctgcccctcc ctgactatgc ccacattaac ccttcagtgg ctgggtctgg 147360gggtagggtg agccccggaa aagccaggca gcgcagagac actctcccag ggctcagctc 147420tgaaccagca gtgtggaagc agtgtgtcca ccacgatcca cactcaggaa ccaaatagcc 147480cttggatacg ttttcagtta aatctttgcc atccaaactc tagctgcttg ctctctaaag 147540ctccagaatg aaatggaatc aagtaggaag ggatgccttc agtatttcag tatttggacc 147600actggccatc tgggtgcaga cagactgaat agcagttctg gttctgatga tttgggtcaa 147660gggagctgtg aattgaagga gtggatagaa ggaatcaaga agcccaaagg ggaacccagg 147720tgggcagaga aagaggtttc aggcccctta tttgggaaag gcagccacag aagaagattc 147780tgtctgggag tggatttcca cccaccctct ccacccagtg acccccaagt ggatccgcag 147840aggcagcccc tgagccctcc ctccccactc ctccccacgg ggagggaaaa cccactgggg 147900aaggtttatt tgcaatggtt ggaggtttgg gtttttttgt gggttttggt ttgttggttt 147960tttttttcct ctttttctct tgctcctcct gtctctttct ctcctgggct tgtgaagttt 148020gctcaatatg gaatgtccta attatttctt tccccgatga agaaggtgtt aattgaggca 148080gagctatttc tgctcctggc ctcgtcaccc aggcggaaat gcgagagaga gagagagaga 148140gagagagaat gaatatgggg cagggcctct tggaaaaatc agccgtgagc agagaaacca 148200ggactcctgg atcctaggtt tctgtgaagt tttattttat gtttttctac cctagactag 148260ctaaaggaga agaggccatg gggttggctt gggtccgagt ggggttttga ggggacagat 148320gtgggtggtg ccaccagagg ggaggaagcc tcgatttagg agaaagactg aaaagctagc 148380tcacgattaa aaatataaga cgtgtgagta agagacagat atatacagac acccaggcag 148440tgggttaatt ttaaaatgta tttataaccg aattcctcag acactctgga cgcttgtttt 148500tctagaagca acgctcagag tgtttcgtgt cggtggttgg ggggttgagg gggattgcaa 148560agctgctaaa gatagacccg ttttcagtag cattcctcag tgtcgggagc ccagttcctg 148620tgtgcccagc accgtgccaa tcgcttagaa ggaagcaaag ataaagtgga aggcttcctg 148680ctttctaaga gcttccaaaa tagttagagg aaacaagacc cctcatttgc agccattttt 148740aacagtgaag gctaatgtgt gattataccc acgcccccct aaatatgaaa attcagtagc 148800tattgtatgc ctgaaagggg ccaggtgcag tggctcacac ctgtaatccc agcactttga 148860gaggctgagg tgggagtatc ccttgaggcc gttagtttga gaccagccta ggcaacatag 148920ccagaccctg tctctgctaa aataaaaatt taaaaattgg ccgggtgcag tggctcacgc 148980ctgtaatccc agcactttgg gaggccgagg caggcggatc aaaaggtcag gagttcaaga 149040ccagcctggc caacatagtg aaaccccgtc tctactaaaa atacaaaaaa aataaattag 149100ccgggcatgg tggcgtgtgc ctgtagtacc acatacttga gaggctgagg caggagaatc 149160acttgaacct gggacataga ggttacagtg agccgagatc acgctactgc actccagctt 149220gggcaacaga gtgagatttt gtctcaaaat aaaaaaattt aaaaattagc catgagtggt 149280ggtacatgcc tatagtccta gctactcagg aggctgagga agaaggatca cttgagccca 149340ggaattggag gctgcaaggc tgcagtaagc tatgatggtg cccgcactcc agcctgggtg 149400acaaagtgag accctgtctc aaaaaaaaaa aaaaaaagag agagaggaag gaaagaagga 149460aggaagggag ggagggaggg actggggctg tgttaactgg gctacacaaa gaggctacat 149520ggagggtggg aattgagcca gacttggaca tggcgtggag acagagaaga ttccaggcac 149580aggtgccatg ctaaacgata gttctcattt attataggaa cccatggatt tattttgttc 149640tctgccctga gccttatgtt taaaagattt ttgccttcca acctgtattt atcaaataat 149700agttcatgta ccaagtccag cataagtgag gaaggcgttt ccaacaactt aagttcatgg 149760cgaggctaga cttggagttt ctattcagcc agagcttgaa aggccaacaa gattcattca 149820ttcagcattg gtttatttcc ctctgctgtg tgctcagtca agggagcaga gaattggtgc 149880tgcgaagtct gtagcacata cattgagaga tatttttgtt gagtaggaag cttgagttta 149940cacacactca gctgtttgtt ttcttgtccg acaatgccac ggtcgtcttt gaaaaccttc 150000aaaagcatcg ctcacagaat aaggtcctct cagacccgct gtgctggtaa aatgaggaca 150060ctcccagatg tgagctttcc tgcctcccta ccccatcaat accttaagat ttggactgac 150120ctttagcgtt cagcctgact gccacctccc caggaagctg tctttggttt ccagcaaaag 150180gggtgtctgt tggcacgttt ctctctcctt gtggcatttt cacagcctgc ctcctgctat 150240ttggggagaa agctcagctc ctgttcctta cccttaggca agggtaggaa ctgtgtgtac 150300tggtgtccct cacccccaga acagctccct gagcccagta catcccaaga agaaaaaaat 150360cagcaaggct tataggagaa taacacaatg cgcttgacaa atttgtccta atggatgtcg 150420gaagaaggct gcacttacca gctacaccat gcacacggca catttactaa aactgactat 150480attatggacc ataaagtttg tctcaacaga ggtcaaaaag ctgaaaaaaa tacaaataca 150540aaacatattt tctgaccgta atgcaattaa gctggaaatc

agtaacaaaa agagaactct 150600aaaagtgttt gcagattaac agacatgcct ctcatttatg gatgaaatga tatgatgtct 150660gagctttgct ttaaaaatat tctaggctgg gtgcagtggc tcacgcctgt aatcccagca 150720ctttggaggc cgaggcgggc ggatcacttg aggtcaggag ttcgagacca gcctggccaa 150780catggtgaaa ccccatctcc actaaaaata caaagattat ccaggtgtgg tggtggccac 150840ctataatccc agctacttgg gagcctgagg caggagaatc ccttgaacct gggagtcgga 150900gattgtagtg aggtgagatc atgccattgc actccagcct gggtgacaga atgagactcc 150960gtctcaaaaa aaaaaaaaaa aaaaaattct agtggcaagg caaagtgttt ggaggggata 151020cagaggaata gatgaaacaa aatttgccag aagtaaatag gtaagtgtct aaattggtga 151080taggtacatg gtgaatcatt atattgtttt atacttctct ctcgctctct ctctcccccc 151140gttctctccc tgtcttcctc tcccctctgt cttcatatat atatatatat atatacacac 151200acacacacac agacacctaa taagtttttt taaaaaacaa atacatctaa attacccata 151260ggtcaaagaa gaaataataa tggaaattag aaaatatttt acttgaacaa taatgataat 151320gcatgacaaa atgttgagat gcaggtaaag ccacacttaa aggcaattta tagccttaaa 151380ggcagttaat ccatccatct caaaagttta ggaaaagaat agaaaaaaaa aaaaaactca 151440tggaaaacat aaagagaaaa gtagtaaagc tcagagaaga aattaatcaa tagaaaacca 151500ataatagacc cccaaagcca aacattgatc tctttgaaga ctgatcacgt ttgtcccaaa 151560agttattcgt tccaacagca ttatagagtc actggtccct atttctcaga gctggttttc 151620cctgctcctt cccctgactt ttctcccctt cccttttgta gatgacattc agggtgagtc 151680tccggctcca tgtgggacag aagagcccgc ccgcacctgc cccaatggga ccaaatgtca 151740gccctactgg gaagggccca acaacgggat cactcagttc gacaacatcc tgtttgcagt 151800gctgactgtt ttccagtgca taaccatgga agggtggact gatctcctct acaatgtaag 151860tgatgctggg acagtgtgtg tggacaatca gagtctcagg gaggtggcct cctgggacca 151920gtgagactcc aaggctgcaa tggagggacc ctgagctggg aaaggcagcc caaggacaac 151980acagccccac tgaagctggc ctgaggctca ggcttttgaa gattacaggg gctcatgagc 152040agaactctaa ctatagggca tagaagtctg gagggccccc agatgcaaca tcatttttca 152100ttgtgcaagt gtttagatat aattttagat ttttgaatac ggaaaggtta tgtgatccaa 152160aaaccaacac agataaaaga tagagtaata tctttggacg taggcgaggg gtccctgccc 152220tgaggctcac ccagtccttc tccagccata ccactccccg tgggatgaga agttcctgga 152280gccaagggga tgtgtctacc aagagcttgt gccccacttt gtaggccatg ttttaagtta 152340ccaggatcct ggaattccct gcccatggcc agattccatg aacttgcgtg caattctcat 152400atggatctgt tcgtaaccca actgagggcc aaggacatcc gaggggtggc tgttaacaca 152460aatgtggcca gagcttggat gtacaagctg gaatgcccac acatatgtgt ggagcccctc 152520tggcaggaca gagccatgac taagaagaga aagggacagg acagggctgg ctctccccac 152580accttgaccc agtgcagata tccggattct aaattccacc ctgaccttcc aaagtgtaaa 152640ggaaggtata tttgcaaagt agaagcacac agcatgtttt atttagttac cttttcaata 152700tttccccgta gtatgtggtc tgcttttgta ctcttgccct agatcttaaa aatgttaggg 152760atgtttctgg aaagatgtat ccctgccccc acttgcatgc tacttcctct tcccacaata 152820tgcaacccct ttagttcctc agaatatcct tccaatgttt atttatgcaa ttataattat 152880aagcataatc gaatctatgt cctcccccct ctttcttatc ccaaggagta gcattctata 152940catgctgttc aattctgtga tttttgtttt ctcataacca cacgttctag agatctttcc 153000actgcaggac atggacagtc tcttcacggg tgcacactag tatgcccagc taatttttgt 153060agagacaggg ttcttccgtg ttgcccaggc aggtctggaa ctcctgggct caagcaatcc 153120tcccgcctct gcctcccaaa gtgctgggat tacaggcgtg agccaccacg cctggccttc 153180tttattcttt tgcacagctg catagcattc tattgtgtgg ctgcccatag ttttatttgt 153240ttgccattaa gagaaatgct tgactggctt cctgtccact gacatggaac atgatgctgc 153300tctgccagga gcatgttgca cgtacctctt catacttttg cagatatagc tagggggttg 153360gagggtctcc attcccagaa gtgggattgc aggatcaaag actaaatgca tttataattt 153420tatttttggg gaagattttt gttttgtttt tttggagaca aggtctccct ctgtcgtcca 153480ggctggagcg cagtggtgta atcatagctc actgcagcct taaactcctg ggctcaggtg 153540atcctcccac cccagcctcc tgagtagctg ggaccacagg cacacaccac catacctagc 153600taatttttaa gaacaatttt atagagatgg ggtctcacta tgtttcccag gctgctctca 153660gactcctggc ctcaagcaat cctcctgcct cagcctccca aagtgctagg attacaggtg 153720tgagccactg cacccagcct aaatgcattt ataattttga tagatattta ggtgtgcaag 153780ttttaaaccc cactctgtcc tcaccacagt tcaccttccc tcacctacta tgcaggtaag 153840cagtccccag gcaggtcact tgtcagcagc tggagtgggg cagagccaag gattcaggat 153900caaacacaag gatgccacaa ctgtagtgac cccatagagc accctggggc tgctccatac 153960acacagctct gttgaccagt ggaggtctcc tcttcacctg ccctaagggc tgaaattacc 154020attgaagttt aggccagcgg ttggcctgac ccgggagcaa tacctggctt cctcctcctg 154080tacatagaga agctgaactt tcctcttggt cctagtgtat gttccttaac aacccattta 154140tgcctagtgt tccattattg gaatgctaat cctgtgggag ttatttacat cctgctgctc 154200aaggtcatca ctaaggtcgg atttttcaca cacacaaaaa ttgcaacctc cggcataaat 154260gggttaagga atttccccac ttgtgggtgg agggagattt gcaaaaactc atccttgtaa 154320tcctgatcaa caaaggcccg ttttagttgg gagtaggcag caaaaggagc cacatgaaca 154380gttgcgcctg tcacgcactg cacaagaatg tcattcatat catagacaac atacgatttc 154440tactgttatc ctgataattt attgacagaa aaaaggatgt ggggaaggga catggtgttc 154500taatttgcat gaaaacctcg tctgagtgta gcatctctgg gaacatgcag cagatccgag 154560ctcaggccct ctcttggccg tcacctgcaa acagcttgga caaagggtca gcccaattgg 154620ccaaaactca ctggggaatt tttgtgggtt ctaggttttt actttgcaag gctggtgtga 154680gaggaggttc cagcaggaaa tgaaccctcc tgagagggaa agagactggg aaatggagaa 154740ggctgggaac tcagggagag aatgggagtg gggaatggga gctgaaaaaa attgtgagca 154800taaaaaaggg atatgtcaca gggttggatg accagagaaa gcgtctgggg gttcagatta 154860agatgctggg ggcgtgccca gtggtgggac aggaagcatg aatttccaga gggctcggtt 154920ataaacatca ttgtccaatg ggtgtttccc ttggaagcct ctaagcttag agctaagcca 154980cctctgggga cacaaactga gtggttaaga gcagagactc aggtgtcagc ctgtctgggt 155040tccttccgac tcttccactt ccttgctgtg cagccttcgg caaggtgctt ggcctctctg 155100tgccactatt tccacatgtg caaaacgaag agaagcatag tcccacctca caaggcacga 155160ggactaagta aggtggattc gcatgaagtg tttagaactg atcctggccc ggggtgacct 155220ccgtgtaagt caaattcccc accctgcatg gtgttccttt tagaaatgtg catgaatttt 155280tcattagaac agctccagca gtgcctgagg aagtggagtg aggtgtgaga ggtcttactt 155340tattcccctc gctggccctg ctattaacca ctaactcaga gtagctttct agcactttcc 155400acacatttac atcccaccct cgtcctttgg ttagcagccc atgcaatgat ttggccttaa 155460tgtgaaccta gaacacagct tctcgcccag ggatgatttc tgcccccagg ggacacttgg 155520cagtggctgc agacattttt ggttgtcaca actggatggg aagaaggagg atgctattgg 155580catcaagtgg gtaaaggcca cggatgctac tcaacattct acaatgcaca gcatccccca 155640cctctgcccc accatagaga atgatccagg cccaaatgtc agtaaggttt ctgtcaggaa 155700accctgggtc agaagaccaa ggttccttga ggacggggat gccttatact gcaatcagct 155760gtcactctct gcctctctct ggggctgctg tgatcacctg gcctgcatgg acaaccccta 155820ggagcagccc ccatccagtg cctggagaag tcagtggata aataccccag ctccctccct 155880gtcgggcgtt ttgctctgcc ctgcatctct ccagtgggat caggctctgg ttgcccgcag 155940ggttaacctg gtcacgtaca cacccttcac ttgccacctt cccttccctg tctggtattt 156000cctgggatga acttttagat ttatttcctg gggctgctat aatgaagcac cacagactga 156060gtagcttaaa acaacaggaa tttatggtct gacagttctg gaagccagaa gtccaacccc 156120aagatgttag cagagctgac aacacgcccc tcaaaagcct ccgggggagg atccttcttt 156180gcttcttcct ggcttttgct ggtttcccac aatctttggg attccttggc ttctagagcc 156240ttcattctcc attccagtct tctgtcatct aatagcatcc tcccagcccg ggcacagtgg 156300ctcacgcctg taatcccagc actttgggag gccgaggcag gcagatcact tgaggtcagg 156360agtttgagac cagcctggcc aacatggtga aaccccatct ctactaaaga tacaaaaatt 156420agccaggcgt ggtgggcggg tgcctgtaat cccagccact tgggaggctg aggcaggaga 156480atcacttgaa cccgggagat ggaggttgca gtgagccaag atcatgccac tgcactccag 156540cctgggtgac agaatgagac tccgtctcaa aaaaaaaaaa aaaaaaaaaa agaaaaagaa 156600aagcatcctc ccttcgtgtg tctgtgtgtg ttctcctctt cttagaagga catcagttgt 156660attggatcag aacctaccct actccagtcc aacctaattt taactaatta cgtctgcaat 156720taccctattt ccaaataaga tcacattctg aggtaccagg gggttaggac ttaaacattt 156780ttgtgtgtgt agcaggagga cgtaattcca tttataactc ctcctaaata aaacgacttg 156840catgtgaact cttgtctggg gcttcccaaa gtgagataac ccctctctct acccctaaaa 156900caacgagtag cgtctgtcaa tgccagggtg caggggctaa ggtgcccatc tttgagtttc 156960tgctgaggag gacacagctg ctacgttgga gcactcttgg gttctgcctt cgtgcccagc 157020catctccctt gggctagccc tgccctgggt ctatcctaga atgagcctcg atctgtttgg 157080ccataggcaa gcagagtgtc tggaaatctt tgtcctccat gactggtgct ggagccgaag 157140ccagtgggtg tggccttgcc agccaactcc atttacccag ctctgaacaa gctagtagtt 157200gagatcaacg gagagtccag acagtcgctc caagcatctt ggaatccatg gacacaggtg 157260taccgcagag gcttcccacc tgggtaggca gccctttgta agatcctggc accacattta 157320ttctcttaac atcctttcag ttatccagta atcatttatt gagcacctac tgtgtgccag 157380gcaatgatta ggtgattgga gacactgcaa cgaagaagac agactaaaat ctccaccctg 157440gtaggagaga cagatgcaaa tggtaaacat gataaataat caatcaccca gaaagcagga 157500gacactaagc aaatgtgtat gtactatggg aagcccaata ggaacgaaag ctacacaaga 157560gaacaagtga tgggtggttc cttagtctag gtcaggcaat cagggagggc ttctcagagg 157620aggtgatgtt tgagcagaga aggagggagc caggcagatg ttttggaaac agcattctca 157680gcatggagaa cagtggcagc tcacctacag gatgtgtttg attcccttcc agattttgta 157740ttcgtttctt gtttttctcc cttggcttcc tggtttaaat gccttttgaa gaaatctaag 157800ctcaactaat cagcgatgct gttgaaggtt tatatcagga tatgcatccc agagttattt 157860acaaaattag aacaaaactg gaagcaattg aaagcctgac aataggagat cagttaaata 157920ccgtatggtc cttccgtatg atggcatatt atgtcatcat taaaaatcgt ctgctgggag 157980aatattaagg atacagggga aaggctcacc atataatgat gagtgggggt gctgggcgca 158040gtggttcatg cctgtaattc cagcaatttg ggagtctgag atgggtggat cacttgagcc 158100caagagtttg aggccagcct gggcaacaca gtgaaaccca atctctacaa aaaaaaaaaa 158160acaaaaatac aaaaatcagc caggcatagt ggcgtacatc tgtagtccca gctactcagg 158220aggctgagac aggaggatag gatcacttga gccctggagt cagaggtggc aataagccgt 158280gatcacgcca ctgcactcca gcctgggcaa cagagtgaaa ccctgtcaaa aaacaaaaca 158340aaaaaaatga tgagtgggag aaacaagttt ttaaacaggg atcaaggagg ccaggcatgg 158400tggctcacac ctataatccc agcactttgg gaggccaagg caggcagatc acctgaggtc 158460aggagtttga gaccagcctg gccaacatgg cgaaacctca tctctactaa aaatacaaaa 158520attagccagg catggtggcg ggcgcctgta atcccagcta cttgggaggc tgaggcagga 158580aaatcgattg agcccaggag gtggaggttg cagtgagctg tgatcatgcc actgcactcc 158640agcctgggca acagagcgaa agctgcacga gagaagaagt gatgcatggt tccctagtct 158700aggtcagcca atcagggagg gttcctaaga ggaggtgatg tttgagcaga gaaggaggaa 158760gccaggcaga tgttttggaa acagcattcc cagcatggag aacagtggca gctcaccctg 158820tctagaaaag aagaaatgat aagaggggaa aatgagtttt taaaaaggaa tcaaggggag 158880gtaaacctta tgatctcaaa ggtacaaata tgaaaatata agtaaagaaa aactggagga 158940cactgtacca agctgacctt cgggtggtgg gatttgggaa tcttgatatt ctcaatactt 159000ctttgtatct tcaaatttct ctatgatgat cacagtttac tttttttttt tttttttgag 159060atggagtctc actctgttgc ccaggctgga gtgcagtggt gcgatcttgg ctcacttggc 159120tcacctctgg ggttcaagca attctcctac ctcttcctcc caagtagctg ggactatagg 159180catgcaccag catggtcagc taattttttg tatttttagt aaaaatgggg tttcatcatg 159240ttggccaggc tggtctcgaa ctcgtaagtt caagtgatcc accaacctca gcctcccaaa 159300ttggcttgag ccaattaaac ttgtcttgct aaatggttag cggggagaaa gaagaaggtc 159360tcgggtcatt cctagaccag gaggcaggga gaaagggagg agaatgaacc tttcttaggc 159420aaacagtgtc ctaggtgtcc ttatcttaca taatctgtcg agagagtcac actaaaataa 159480atcattgatt gattgattga tacatcaata ataaatggcc agccttggtg gctcacatct 159540gtaatcccag ctacttagga agctgaggtg ggaggattgt ttgagacaag gagttcaaga 159600ccagcctggg aaacacagca agactcatct taaaaaaatt ttttttttta attagccaga 159660tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggt ggatcacgag 159720gtcaggaatt cgagaccagc ctggccaaca gggtgaaacc ccgtctctac taaaaataca 159780aaaattagcc aggcgtggtg gcacacgcct gtagtcccag ctacgcagga ggctgaggca 159840gaagaatcat atgaacctgg gaaacagagg ttgcagtgag ctgagatcac gccattacac 159900tccagcctgg gcaacaagag caaaactaca tctcaaaaaa aatgtttttt aattagccgg 159960gtgtggtggt ccatgtctgt agttccagct acttgggagg ctgaggcagg aggattgctt 160020gagcccagca gttcaaggct gcagtgagct atgatcccgc cactgcactc cagcctgggc 160080aacagcaaga ccccatctct taaataaaca cataagtaaa taaatgatca tttttatttt 160140attattaaat acacaagata aatgaaaaac aggcaaatct ttcttacaaa agaattccat 160200ttaaagtatg taaacttcac tccccactgc cccaggaggt ggagactaat ctcccctact 160260ttgagagtgg gctggattta gtgactcatt tccgaagaat agagtaggta aaggggaaaa 160320tagaagtttt atagcggagg aacagataga taccacttta accaaatgat gaagattagt 160380atcccccagg gatgtggata ttatgtaacc cttgatttta tgcctatata gcgttcttcc 160440caaaaactcc taatcccagt tttttggggt tttgctctgt cttctaagct ggagtgcgat 160500gatgcaatca tagctcactg cagctcaaac tcctggtctc aagcgatcct cccacctcaa 160560cctcctgaat agctagggct gtaagcacat accatcatgc ccagctaatt gtattttttt 160620ggtagagaca tgttctcaca cattgcccac gctgtcctcg agctactggc ctctagtgat 160680cctcccaccc cagcctccag agtcactggg attataggca tgagccactg tgaccagccc 160740agaatttttt tttaaggagt tgtgatgtcg tttaagagat gtgattcttc ataacacatc 160800aacaacaagt cccagcgatg ggttggataa gtcttgggat ttcatgggag tattaagctt 160860aaaagacttt gcatgatatc tgtgaactat atgtgatttc tgttggtaat gggggtcact 160920gattctgcgg tttgccacct ccaatcatca tggaagaaaa tgttccactt ccagtgaaag 160980taagaggaag taaaggggta attattttct atctaaattc acgaactcct tgaattctgt 161040ccacagaccc ctaagtgttt cctccccaag gtgaaactga gagaatcttg ccagtgcctt 161100ccgcagtcac tgtggctaga aaacccctca gaagaggtga tagtttagca ggtaactgga 161160gttctcacca tccgtgtctg gctcagcccc catcacaacc agttacccag cccaaaatgt 161220cagtagtact gaggttgaga ggctctgctc taggaggcca ggcctctcag aggaaggagg 161280attggggtac tggctgggcc tcaagatgaa cctaccccct aagagctttg ggatggcgtg 161340agtttctgtc catacccaag gactacaaat gcaggtttac tggaaattct gtgccaaaag 161400tgaggtccaa ctcacttcta actgctacaa aacaaacctc catcaacata gcccatctct 161460gttcttgacc tggaagctcc aaggtatcca catggctccc atgcccacta gacgggcctc 161520ttccctggac cttcctgggc cagagaaggc tctgggtagc cttgtggaat caagatgggt 161580gatcagccac ttcctctgtg ccaccctgtt ttggctactt ccctaggcat cagcctggga 161640ttccttgatg gtaaaaatat aaaactctct gagctagggc ctttaatatc cccattttac 161700agatgaagaa actgagtccc agagctgtgc acagcgattg agagtcagaa ttcagctctg 161760tctcactcag tgtcaacatc ctcagattct gccatttata gcctcccaca gcaaatagga 161820ttgagggctg cttctctgag ctcaagggga tagaatgggg aaccccatga gtactgcaac 161880aaaactgttt gctggagaca agagctggtg gctctgtgtt gttctagtga caggtggcct 161940catttcacag ggaccccctc accctatgtg ccccatgtgg ctcagaaaag ccagaaattg 162000tctccactct cacaggggaa ggtccctgac cccctctttg ccagctgggc caaggcaaat 162060tggggtcact tcatggggta caggacctac cctctcttgg ttgcccccaa ggaggggatg 162120tggaggggct ggggacctgg caggaccagg gtgtcttgag ttaatttggg gctgccttta 162180gccgagggct tctgtgtgcc tggcatcagc tttacattgt gtcttgatcc gtaaaacagc 162240cctgtgagga aagatatttt taaccccatc ttccagatga ggaaacggag gcccacaggg 162300tgacgtgacc tgccaaggtc ccctagccaa gagtgacaaa gccagggttc acacacagct 162360ctggacacaa ttcatcaccc ttcatccgtc tctctctgac tctttctttt tccctctctc 162420tctttgtctc tctttttttt tttttttttt tttgagacag cgtctcactc tgtcacccag 162480gctagagtgc agtggcgcaa tctcggctca ctacaacctc catctcctgg gttcaagcga 162540ttcttgtgcc tcaacctccc aagtagctgg gattacaggt gcgtgccacc acacccagct 162600aattttgggg ggttttgttt tgttttgaga tggagtcttg ctctgtcgcc aggctggagt 162660acagtggcgt gatctcggct cactgcagcc tctgactccc aggttcaagt gattcccctg 162720cctcagcctc ctgagtagct gggactacag gcatgcacca acacgcccag ctaatttttt 162780gtattttagt aaagacgggg tttcaccatg ttggccagga tggtctcgat ctcctgagct 162840catgattcgc ccgccttggc ctcccaaagt gccgggatta caggcgtgag ccactgtgcc 162900tgccaatttt ttgtattttt aacagagact gggtttcaac atgttggccg ggctggtctc 162960gagctcctga cctcaagtga tctgcctgcc ttggcctccc aaagtgctgg tattacaggc 163020atgagccacc atgcccagcc tttgtctctt ttattcttgt gttctctctc tctcttcctt 163080ctctttctcc acctccttct ccttctctcc cttctcctca cccttctttg tgcttttctc 163140tgtgagtttc tcttcttctc tatttctctc ctttggtgaa tgtcaattag aaaagcagaa 163200aaactgcgtt taatttgtga tcataaatgc atgtccctgg ccaggcgtgg tggctcacgc 163260ctggaatccc agccctttga gaagctgagg caggaagatt gcttgagacc gggagttcaa 163320aaccagcctg gtcaaaaagc aagaccccat ctttaaaaaa gaaaaataat taattagctg 163380ggcatggtgg tgtgtacctg tagtcccagc tactcgggag gctgaggaag gaggattgcc 163440tgagcccaag ggtttgaagc tgcaccgagc tgtgattaca cccctgcact ccagcctggg 163500tgacagaacc agaccctgtc tcaaaaaaaa cctaataatt aaaaataaat aaataaataa 163560atgcgtgtcc cctggccagt ggttgctaat gtttggaatc acctttgacc catgcccttt 163620ttcattcata gatgtttgtc ttgaccaaaa tcaaagcatt agactttgga ctataaatca 163680ctggttcatt caacaaccat cattgaatgc ctactgtatg cagacactct tctggacaca 163740gaggagttga cgtgttggtg gggaaagcca gtgatcagtt gggataaaaa gggcagacag 163800cagacattaa atagtttagg ctttgtgggc cagatggtct ccatcgcaac gactcaatct 163860gctcctgtag cgtgaaagta acgacagata aagcgcgtaa gtgaatgagc atggctgtgg 163920gccaattaaa cgttaaccta taaaaacagg tggctggccc gcgggctgta gtttgtggat 163980cactgcctta gagatagtgt tagagggtgg tgagaggtcc gggatagaat aaaacagtag 164040agagtttgtg cattgtcaag atgagaggtt gcagttcttc ttatacaccc cgaatggccg 164100ggcaccgtgg ccattatgat ctataattct aacactttgg gaggctgagg caggaggatc 164160ccttgagccc tagagtttaa gaccagccta ggcacatagt gagaccccat ctctacaaaa 164220aaaaaaattt aaaaattagc tggacatggt ggagcatgcc tgtaggccca gctacttgag 164280aggctgagat gggaggactg cttgagcctg ggaggttggg gctgcagtga gccgatcatg 164340ccactgcact ccagcccgga tgacagagca agaactgtct caaaaaaaaa aaacaaaaaa 164400acaaaaaaaa cagacctgaa ggaacaaatc atatgaatgc attaaagtat cacatgtatc 164460caaaaaatat atacatctat cagcctggca cggtggctca tgcctgtaat cctagcacat 164520tgggaggcca aggcaggcag attgcctgag ctcaggagtg caagaccacc ctaggctaca 164580tggtgaaacc ccgtctctac taaaatacaa aaaattagct gggcatggtg gcaggcgcct 164640gtagtcccag ctacttggga ggctgaggca caagaattgc ttgaacccag gagacagagg 164700ttacagttag ccgagatcgt gccactgcac tccagcctgg acaacagagc aagactctgt 164760ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaatatata tatatatata tatatatata 164820tatatatata tatatatata tataatcaat taaaaatttt ccttaataaa taaacatttc 164880tctccttctc tcccttggtg aatgtcaatt aataaagcaa caaaactatg tttagttagt 164940gatcattaat gtatgtccct ggctgggtgt gatggctcac acttgtaatc ccagcacttt 165000gggaggctga ggcaggagag gatagtttga ggccagcaat tgcttgaggc tttttgaaag 165060acatgaagga gatgaaggga gccatggaga tatctcaggg aacagcagcc gaggtagatg 165120gaacagccag tgcaaaggtc ctgaggcagg atgttcctgg catttgtgag gacatgtagc 165180tgcccagatg tccagtgggg agtgagtgag gatgaaggaa ggagctgatg aaggaagatg 165240ataaaatact tcatggatca gccaggcatg gtggctcccg cctgtaatcc cagcactttg 165300ggaggccaag gcgggtggat cacaaggtca agagttccag accagcctgg ccaacatggc 165360gaaaccccgt ctctactaaa aaatacaaaa aagttagcca ggcgtggtca tgcacgcgtg 165420tactctcagc tacttgggag actgagactc gagaatcgct tgaacccagg agatggaggt 165480tgcagtgagt tgagatcacc ccactgcact ccagcctagg tgacagagcg agactctgtc 165540tcaaaaaaaa aaaaaaaaaa aaaaagactt cgtgaacaga cagcctatat aatttatgat 165600ccaaaccagg acagttttga gagtgaaagg ggaaaaagag

cactgaaaaa ataattagca 165660ggcctggcat gatctataac gggtataaag tgggacacac agcctctctc acggtcactg 165720tcagacttca gctttttcac actcaaatcc acccccatgt ttatcccata tactggagaa 165780acgggtgttc tcctgagctg agttttgggg ttttttcctt ttgttttgtt ttgtttttgt 165840ttttttaaca tcctgtatac tttttctcaa tgaaccatgc tcaaaaaaat tagaggaaaa 165900taaaccataa aacagaaggc actgaaggat tttgctggga ctcagccatt agtttgtttg 165960atgagtattt atggagcgct ttctaagcac caggcaccac cagcgatact gggatgaatc 166020agtaacatcc ctcacccttg aagctctctt gggcccattg ttatttactt aaaatactat 166080gcaagtacgg agaaggggtg aagtgggaaa aaatcagttg gttgtaaagg ccagaatgac 166140gggtctagtc ccacccatgc catctgcacc ctgtgtgatc caggcacatc atgttgcctc 166200tctcagcttc agtttctcca tccaccaggc acagagatgg cgggaatcga ggaagatgtg 166260gggagtattt catcagccca aaaagacttg gctaatgcga ccataattct gccttctgcc 166320tctcctttcc cagaaaaata gcttaatcat ttggatttgg gataaacaca tttcctgtgt 166380ttattattta aatgatccac caagctgggc atggtggctc acccctgtaa tcccaactct 166440ttgggaggct gaggagggcg gattgcttga gcccaggagt tcaagaccag cctggccaac 166500atggcgaaac cccatcttta ctaaaaaaat acaaaaaaat tagctgagcg tggtggtgcg 166560tgcctgtaat cccagctact tgggaggccg aggcacaaga atcacttgaa cctgggaggc 166620agaggttgca gtgagcctag atcgtgccat cacactccag tctgggcgac agagtgagat 166680tctgtcccta aataaataaa taaataaata aataaataaa taaaataaat gatccaccaa 166740caggaacccc aggaacattt gtattgacta tgcaactaat gcttagtgag cacctactat 166800gtccctggtg ctgatctgga cactgggatt tagacaggaa aaatctctac cctggaggag 166860ctgatgatca agatgacaat cttgaaatgc ataagttgac aagatgattc agacagtgga 166920acgtgctggg aagagaatga gatgtctggc tgagctgcag gaaggggcaa gtccttttga 166980ttgagaggtc caagaaggct tctctgatgg gggcacaatg gatctaaggt tgagtgataa 167040gaagaaattg gccaagccaa gacctaaagg cagagttgct ccaggcatag gttcagagaa 167100tggaaataat tggctgattg tgatcttgaa cttgaccttt cttttcttct gctaactttg 167160ggtttggttt gttcttgctt ttctggctcc ttgaggtacg tgttgggttc ttaatttgta 167220attttttttt tttttttttg cttttttgag acagagtctc actgtggtgc ccaggctgga 167280gtacagcagc atgatcttga ctcactgcaa cctctgcctc ctaggctcaa gtgaacctcc 167340cacttcagca tccccagtag ctgggactac tggtgcacag caccacaccc agctaatttt 167400tttattttta ttttttagag atggggtctc actgtgttgc ccaggctggt ctcaaacccc 167460tagctcaagc gatcctcctg ccttagcccc ccaaagtgct gggatgagag gcgtgagcca 167520ccacatctgg cctctgtttt ttgtgatgta ggtatttgat gctataaact tccctcttag 167580ttgcttcttg gccctttagc taaggtcaag tgtaaacttc cctcagcact gcttctgctg 167640catctcacag gtgttggtgt gttgtgtctc tattttcatt catttccaaa attttttaag 167700tctccatctt aatttctgca ttgacccaat ggttgttcag gagcatgttg cgtaatatcc 167760atatatttgc atcatttctg aaattcttct tggtattgat ttctagtttt atcccacggt 167820agtctgagaa gatgcttgac agaattccag tattttaaaa tttgttgaga gttgttttgt 167880ggcctaacat gtggtctgtc ttggagaatg tccatgtgct gatgagaaga atgtatgttc 167940tccatcagac atgcaagaga cagacacttt ctcacctgcc tcatgggatc cataaaagag 168000tcaatcagaa gttggcattt aagaaagacc agaaggaggc tgggtgcagt ggctcatgcc 168060tgtaatccca gcactttggg aggctgaagt gggtggatca cctgaggtca ggagttcaag 168120accagcctga ccaacaaggt gaaatcttgt ctctatttta aaaaatacaa aaattagcta 168180ggtgtggtgg cgggcacctg taatcccagc tactctggag gctgaggcag agaatcactt 168240ggacccagga ggtggaggtt gcagtgagct gagatcacac cattgcactc cagcctgggc 168300aacagagcaa gaccccatct caaaaaaaaa aagaaagaaa aaaaagaaag aaagaccaga 168360aagaggtgaa ggagcaagct acagagatat caaactgtat caatctggct gggcgtggtg 168420gctcatgcct gaaatcccag cactttggga ggctgaagca ggaggatcac ttgagcccag 168480gagttcgaga ccagcctggg caacagagac cccctctcta caaaatataa aaatttaatt 168540aaaaagatgt attggtcagg gcagccaagt tatgctgcag taacaaacat ccccaaagcc 168600tccatgactt ttgacaacag atgtatttcc tgctcatgct acatgtccag tgcaggttgg 168660cagtggggaa gaagggggct ctgttcagtg cagtcacttg agacctagct aatcacctag 168720aacattgcca cttgctattc cagaaggaaa aaaggaatgc tagaaggtcc cacactgaaa 168780gttcaatgct ctggctccaa aatgacagct atttccactc actcctcatt ggccagcact 168840tagcatgtgg tcctcagcca accccaaagg gactcaggaa ggaccatccc accatattgc 168900tggaaatatt tgatggcagc attaatgggg aacagtgttc caggcagtgg aagtctttga 168960gcccttggaa gaaagacaag gcgatctcta gagcacatcc ttcccaatat taatgaattt 169020aacaaatgag caagccatcc tcccccactc tccttcccga attcagactt gtgcatatcc 169080ctcccttaac ttgaactgcc aaagaagaga tgagaaccag gagaagagat ctgtgacccc 169140atctttgctg atgaactacc acagaacagc catggcatct ccagtccttg tgcttgtaaa 169200atgtactttt cattttgctc ctgaacgaaa tccacccacc cccaccccca aaccagggaa 169260agctcatctc ctaatccaaa actgcaccca gccttccacc accttcttcc ctgggaattg 169320ttgattccag agtatggaat tgaataattg gatgagtttg gaagagaaaa agtgtctcta 169380aaatcaggca gcagaagccc actccccaga gaggatggtg cagatgagag ttcaggaggg 169440agcttggctt ggggttgacg atctgagcta tgcagggaac ttggacacac ctctcaatca 169500gtcattcaac agacaccact tattgagcac cgactgtgtg ccagatgttg tcctaggggg 169560ctgggaatac aggaatacag cagggaacaa aaaggacaaa gcccctccct cttgtcgaat 169620ggacattcca gccaggaaga cgagagaaca agagaaataa gtaaagtata taggcggtga 169680aatgcaaatg ggaaaaaaga aacaatgggg accagaaatg aggggtgcaa ttgtaaaggg 169740ccatcagggg aggcctccct cagaaggtgg catttgagta aaaaacctga aggaggtgag 169800gggaaaccat gtagcaatct caggaaagag cattccaggc agggagggac agcctgtgca 169860agggccgagg taggactgtg cttggcgtgg ttgagaaact gcaaggaagc caggtggctg 169920gaaccgaatg agcgagggaa aaggggagga gataaaagca aggagatggg agggttggag 169980gccccctctg ccattcagta actgagtaac ttcatttatt tcctgtagct tgaaccacaa 170040agaaccacaa atagagtagc tgaaaacaac agaaatttat ttattctctc gcagttcagg 170100aggccaggag tccacagacc atcaaggtca gctgggccac agaccatcaa gatgtcagct 170160gggccatggt gcctcctgag acttggtctg aaatcccttc ttgcctccct cctagcttct 170220ggtggtttgc caacagtgct tggtggtcct tgtcttgtag acgtatcacc ctgatcccgc 170280cttcatctcc atttcacatg gccttctccc tctgtgcaag gttgtctctg tgcccaggtt 170340tctccttttc ttattattta cttatttgtt tgtttgtttc tttattttag acacagggtc 170400ttgctctgtc tcccaggctg gagtgcagtg gtgcgatcat agctcactac agcctcaaac 170460tcctggcctc aagcaatcct cctacctcag cctcctgagt agctgggact gcagatgtga 170520gccactgtgc tctgcccaga tgtcctcttt ttataaggaa acccgtcatt taggatgagg 170580ttccacccta atgacctgat cttaacttga ttccatctgc aaagacccta tttccaattc 170640ataggtacca gggattagga cttcttcaat gcatcttttt ggagagaccc actgcaaccc 170700acaacagaac tgtgggcatg taacttgacc tctcggccag gcgtgatggc tcacacctgt 170760aatcccagca ctttgggagg ccgaggtgag tggatcgcct gaggtcggga gttcgagacc 170820agcctggcca acatggtcaa accccgcctc tactaaaaat agaaaaatta gctgggcatg 170880gtagcaagca cctgtaatcc caactacttg ggagggtgag gcaggagaat tgcttgaacc 170940caggatgtag aggttgcagt gagccaagat agtgccattg cactccagcc tgggtgacag 171000agtgagactc catctcaaaa aaaaaaaaaa aaaaaataga cctctctgtg cctcagcttt 171060ctcacccggg aggatgggga taattatata cccactcctg gggttcatga gaggattaaa 171120tgagctcaaa cagtccaagc ctccacgtgt gtctgttgtg gtgctgggta gcatgtcctg 171180tggccagagg ttcccaagct tgtcgaggac ccaggcaagg gcagattcgg gtcttgttgg 171240cagcacctga gatggacggg ctgccttggt atggaagggc ctcggctgtt tttccctttc 171300agtcctgtcc ctctccccca tcctccaccc tgtccctgtc atctgagcct gctcctcgtg 171360atggctcaga gtctccctac tggcggccgg tgcagagttt cgttccctgg gctatattta 171420gccctgagaa atgggaacga gaaccctcag ccgccaaagt gatggagaga ggagcacaaa 171480gccagtgctg ccttctgtcc agcaatgttc cgctgactcg gttctttctt ccagaacctt 171540ccagaagcaa agcattggca tttctgagct cgttaaaaca aggatgtggg ctggtggctg 171600gcacattcat tgtccccaga acctgtctgt gtccatgatt aaagctgact ttgttagttt 171660tattttcagt gctttttttt ttttttaatc catggcaaaa cacacatgac ataaaattta 171720ccatcctaat atttttttta actttgtaac attttttaat tgacaagtaa ttgtacttat 171780tcatggggta catagtgacg tttcaatgca tataatgcgt agtgctcaga tcagggtaat 171840tagcatatcc atcttctcag acctttattg tttctttctg ttaggaacat tcaagctcct 171900ccttctagct atttgaaacc attaatatat tgttgtcatc ctaaccattt ttaaggatac 171960agtttcgtga aattaagtat aatacattca cattgttgtg caactgtcac caccatccat 172020ctcccaaact tttccatctt ccaaatgtaa ctctgtcccc actaaacgcg aactccctgt 172080tccccctccc ccagcccttg gcacccacca tgctactttc tgtttttata aatctgacga 172140ctctagggac ctcctataaa tggaatcata caggattttc ccttttatga ctggtttatt 172200tcacatagca taatgccctc aaggttcacc catgttgcag cacgtatcag cattttcttt 172260ctttttaagg taaagttgac tattaaaaaa aaacttctgc cgggctcagt ggctcacgcc 172320tgtaattaca gcactttggg aggccaaggc aggcagatca ggaggtgagg agttcaagac 172380cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaaatt agccaggcat 172440ggtggcgggc gcctgtaatc ccaactactc aggaggctga ggcaagagaa ttgcttgaac 172500ccgggaggca gaggttgcag tgagctgaga tcatgccact gcactccagc ctcggcaaca 172560gagtaagact ccgtctcaaa aaaaaacaac tttttaagaa ttgaagtaga ataaacatac 172620agaaaaatcc gcggattata agtgaagagc ttgattaatt gtcacaaact aaacacatcc 172680atgtaaccag cacacaaatg aggaaacaga aacttctcag ccccagaagc ccccctcata 172740tcctgttcct agtcactacc tccccgcaag ggtaccccta ccaggacttt gagcatcatt 172800caccagttta gcctgttttg tattttgcat aaatgaagtc tggcttcttt tgcttgacgt 172860taacttttta agatctcatg tgacctgtgg cattgttcat tgcatgtatc ctctctctcc 172920tattgataac agtgtggatt gtttgcaatt tggagctatg atgaatacca ttgctatgaa 172980tgttcttgtg tgtgctttct gttgtgtaat tattcagaat tactatttcg gaattactat 173040ctaattgtag tgatcttgga tcagtaacta tccaagaatt actgggtgtt ggcaaaggta 173100catacagtta tacactgcac aatggcattt tggtcaacaa cagatcaaat atgtaacagt 173160ggtcccataa tggaccgaat acataacagt gattatcata cagtattttt actatagctt 173220ttctgttttt agattctttt ttttttgaga cgaagtctcg ctctgttgcc caggctggag 173280tgcagtggtg tgatctccgc tcactgcaag ctccgccttc tgggttcacg ccattctcct 173340gcctcagcct cccaggtagc tacaggcgcc cgtcaccagg cccggctaat tttttttgta 173400tttttagtag agacggggtt tcaccatgtt agccaggatg gcctcgatct cctgacctca 173460tgatctgccc gcctcggcct cccaaagtgc tgggattgca ggcgtgagcc accgcacccg 173520gcctgttttt agatattttt agatacacta tagagttaca attgcctaca gtattccata 173580gaataacatg ctgtatgggt ttgtagccta ggagcaatag gcgagaccat gcagcctagg 173640tgtgtagtag gctataccat ctaggtttgt gtaagtacac tccatgatgt ttgcacaaca 173700aaatgaccta gtgacacatt tttcagaatg tatgcccatt gttaagcatg acttaatttt 173760agcatagaaa ctctcaacca atttttcaag tagttgtacc atgtgttatg ggttttattg 173820tctcacccca aaattcatat gttgaagtcc taacccccag tacctcagaa tgtgacctta 173880tttggaaata gattcattgc acatgtaaag gttttgccat tggcaaaact gccgttattt 173940ttgcaccaac catagcagtt aagatgagat cattagggtg ggtcctaatc taatacgatg 174000gtgtccatat aaaaagggga gattttggca cagagacagg cacactcaca ggaagaatgc 174060catgtttaaa caaaggcaga gctcaggatg atgcctctac aagccaagaa tcagcaaaga 174120ttgccagcaa accgccagaa gctaggagag aggcataaaa cagattctgt ctcacagctc 174180tcagaaggaa ccagcccttc tgacaccttg agcttggatt tttggcctct ataactgtaa 174240gacaataaat ctttgttgtt taagccacct aggttgtggt tccttgttac agcagccaca 174300ggagatgaat acagcatggt gccctcccat tggcagatta tgagggttcc agttgctcca 174360cagcttcaca gacacctggt agtaatgacc tcatcttaac ttctttctca ttttagcctt 174420tcttccaggc agcagcagtg tcatacatgc ttttaaaggt gggcttttaa agccacactt 174480gagagccctg cattctgcag gtgtcacagg gtgatcaact attcaaaggc tacccctgcc 174540ctgacagctg gaggcaaggc ttcccagcac agaggttaag cccatggact ctggggccag 174600gtggttagtg caaatcccat gtccactagt gaataactct gtgatcttgg gctgatgatt 174660ttgtctttct aagcctcagt ttcctcaata gtaacatggg cattataaca tagaggcatc 174720atgaggatta aatgactaag tgagctaaca tacataatgt gcttaggaag gtgccagcac 174780accataaata ctctgtaagt gctggctttt atcattcttt tctctctctc tctctctctc 174840tctctctctc tctctctctc tctctccctc tctctctctg tctctctttc tctctccacc 174900ccccaacctc ctctccttga ttttcttccc ctcatcttac ttccttcttg ctatagtgtt 174960ctattttctg tttcagagag tattctattt gtggactttt ttcctcttga aaattgagct 175020gaaacttctg agaatttttt gtgattggca ttaaggctgc agggaatgga gcagggagac 175080acttgaggaa agggctcatg gaccatctgt ctggcttggt gatttcacca ggccatcaga 175140ctctgtggtc atgcatctcc tctaagggga gtctatgact gtgttgggag aagagaagga 175200accagggatt aattaatcca tttcaatagg ttttgtgttt tgtttggttt actttttcct 175260tctccttctg gactgtggtc tgggaagtcc tcttgtgttt cttactccat tcccaggtca 175320attatgttat gtgaggagaa cataattaag agagagcttt accctttgga tgttttcttc 175380agaaaacgtt cctccatttc cccctctggg atgccagagc cccagaactc cacaagccaa 175440gaacatttaa gacagagcca caagagaacc gagcttcccc ttccctcacc tgtcaggttc 175500tatctgagtc ccagtcaact ctcacctgct ttccctcctc acaccctaca gagcaacgat 175560gcctcaggga acacttggaa ctggttgtac ttcatccccc tcatcatcat cggctccttt 175620tttatgctga accttgtgct gggtgtgctg tcagggtaag tttctgctac tccccacccc 175680atcccactca ctcctctttg ctaacttctt tccaagtaga ggccattgaa gctttgtttt 175740cattcactag acagagaaaa ggcttcttcc cttgtttggg ttaccagact gttattagca 175800agccatgcac aggtgcagag gttgtgtact gctaggggta cccagtgaga gggttcatat 175860gggctttact ttctttacat tttttttaaa aaccaatagt ttgggtttac ttctccccca 175920ttttccaaat ataaaatcat agcatatgct ctaacggtgt attttcctga cccatattgt 175980cctctatccc caagattttt ttggcttaat cataaatggg cttcattttt cttaccataa 176040gaagtctggg cacttgtatg gtggctctat ggcaccatca gcaaccccag attcttccag 176100ctttccattc tgacatcttt accagaggct tccaatctcg tggatacctc atggtcttaa 176160gatggctgcc tcacgccctc cggatggcca cttcatgttc caaacaggaa aaggaagaag 176220ggaaacagga agaggtggga cctatggcag agaagccaac ctgctgcaga aatctttcat 176280tcatggctta ttggtctaac ttaaaagagg gctgaaataa ttattagcca aaagtatgaa 176340gagaatgaga atgaggtatg cagccagtgg tggttggcat ggcatggttt tatcctttcg 176400gtttttttct tttttattgt ttttttttga gacggtgtct agctttatta cccagactgg 176460agtgtagggg gcgatcatag ctcactgtaa cctagaactc ctaggcacaa gcgatcctcc 176520tgcctcagcc tcctgagtag ctaaggcaac aagtgtatgc caccatgccc agctacattt 176580tttatttttc atagagatgg ggcccactgt gttgtccagg ctggtctcaa attcctggcc 176640ttaaatgata ctcccatctc agcctcacaa agtgctggga ttacagacat gagccactgt 176700gcctggcctt tttctttacc taggcacagt tgtcgggaaa tgtgtgaagc tggcagaagc 176760acccatcact ataatatccc agtcttttcc cagaagtcct gactcctcct gttgaaaact 176820cctgacctcc agggacttct gaatccccaa acacacacac acacacaaac acacacacac 176880acacacacac acacacacaa acacacacac aaacgtttcc taacattttc aaaacagcca 176940tactctggct tttctatgct tctccaggga gtttgccaaa gaaagggaac gggtggagaa 177000ccggcgggct tttctgaagc tgaggcggca acaacagatt gaacgtgagc tcaatgggta 177060catggagtgg atctcaaaag caggtgaggc cctttcatcc tggggcccag ggatggagat 177120cccaggccac ggagtacaaa gagagtcatg cagtttggag aaggctaagc tgggagggtt 177180atgatgggag gagaaagaga acctgaattg gtagtcccaa attttatcaa caagaatcca 177240gagtctgata tgaagaagtc taagatgaag ccaggatctg acatcacgta acttgaattc 177300tgaaatcaga cgctggttta catcccggcc ctgccacttt ttacccatgc accacacatc 177360cctgtacctc cgtttcctca gctgttacat ggaggcgatg gtagtgccta agtcatagta 177420ctattggagt atttagtaaa ataatctcag ctgagtcact tggggagaga agtgcctgat 177480acacggtagg cacatattta tttgttcagc catttaacaa acatttaggg agcacctgct 177540gtgtgccagg cactgatcta agcactgagg atatgggagt aaacaataca caccaaatcc 177600ctgccctcag agctctgata ttctaatgag agagataaag caaacaaata catgtcatgt 177660tgggaactcc caaattcaga gaaggaagat aaaacagact aggaagataa aacagagtag 177720gaagttggcc gggcgcggtg gctcacgcct gtaatcccag cactttggga ggctaaggcg 177780ggcagatttc ctgaggtcag gcattcgaga ccagcctggc caacatggtg aaaccctgtc 177840tctactaaaa atacaaaaat tagccaggca tggtggcgca cgcctgtaat cccagctact 177900cgggaggctg aggcaggaga attgcttgaa cccaggaggc agaggttaca gtgagctgag 177960gtcgcaccac tgcactccag cctgggcaac agagtgagac tctgtgtcag agaaaaaaaa 178020aagagtagga agttagaggc agggtggtca gggaaggctt ctctaaggaa gtaccctctg 178080agcagagaga cctgaaggac gtgaagaagg aagctgtggg gatgtcaagg gaaggggcat 178140tccaggcaga gacagcaagt gcaaaggccc tgagctagga acgtatttga gacacagcaa 178200ggaagccagt gcagctgaaa cagagtgaga ggtggggaca gctggaggag aggaagacag 178260gaaggtgatg gagatcagat caagcagggg cttataggct gtggtgtgga cattggtttt 178320tattttgcgc gaggtgggga gaatgttggc tattgctact gttgcggagg tggggcttga 178380agtcacaaac cacccagcag catgtttttt ggtcggttga gctgtcacca tcagtcagca 178440gagaatgggg gtggccgggc agacccttct tcctggtcca agggagaact catcctccaa 178500atgcaggagc ttaactctgt gctcttcctc ttcagaagag gtgatcctcg ccgaggatga 178560aactgacggg gagcagaggc atccctttga tggtaactgc tctaaaccca cctcaggggt 178620gggtcccagg ggagaaggga gaagctgtgg tggggagtcg ggggagagca ggtgactggt 178680tctaaggatc ttgcagaggg tagacgttcc tcttggagga attttaggac ttccatgcag 178740agtttcccta ttctggcctc cacttttttg ttttaaccat ggacctggtt ttttctgctt 178800tgtgccttgg tttttctcat ctgcaaaatg ggtatgatat aaacaatacc ctagctcacg 178860agattgtttc tcagaatgat attcgttatg gcaaatagaa cacctgggat agtgcctggc 178920atggggtcag cacgtttctg tttgctaaat aagtaataat tccaccaata atccagttta 178980ctgtgaacgg ctgctgtctc ccatgttaga aacttaacga gacagaacca tgactttctt 179040tcttttcttt tttttttaat tgagacagag tctcgctctg tcacccaggc tggagtgcag 179100tcacacgatc tcacctcact gcaacctctg gctcccaggt tcaagcaatt ctctgcctca 179160gcctcatgag aagctgagat tacaagcatg agccaccatg cctggctaat ttttatattg 179220ttgatagaga tggggtttcg ccatgttggc cgggctggtc ttgaactcct tgcctcaaat 179280gatctgcaca ccttggcctc ccaaaatgct gggagtgtag atgtcaattc atggtcccct 179340ggaaacctga atatgaaagg agggaccatt aaaaaggtgt ccaaaagccc aacctcccca 179400gcatagctgg gagtcagggg acagactgta agagtcactg tgtatccaac ctgaggcttc 179460atgaaagtaa agtttcctag aatttagaga tagggttgga tgcggtctgt ctgtggctca 179520catctgtaat cccaacactt tgggaggcca agacaggagg aacacttgag cctgggagtt 179580caagaccagc ctgggcaaca taatgaggtt ccgtctctac aaaaaataaa cttagccaga 179640tgtgggggca cacgcaccta tggtcccagc tactcaggag gctgaggtgg gaggatcact 179700tgagcccaag aggtcgaggt tgcagtgggc accactccac tccagcctgg gtgacagagt 179760gagaccctgt ttcaaaagaa aaaaaaagaa tttagagata ggccagaata atatgtctgc 179820aatataataa taacagcaat aagaaaaata atagtactcc ctgaaaaatg caacttcttg 179880cttgagattt atcttctcat actttagaaa actggttaga caggggctgg gcgtggtggc 179940tcatgcctgt aatcccagca ctttgggagg ccaaggcggg tggatcactt gaggccagga 180000gttcaagacc ggcctggcca tcatggcgaa accccatctc tactaaaaat acaaaaatta 180060gctaggtgtc atggcacacg cctgtaatcc cagctactca ggaggctaaa ctacgagaat 180120tgcttgaacc tgggagacgg aagttgcggt gagccgagat cacaccactg cactccagcc 180180taggcgacag agcaagactc tgtctcaaaa aaaagaaaga aagctggtta gacagggtga 180240tgacttttga ttaaaaatct gagagatttg agggaaataa aagaactggc actgcgtccc 180300agaaggttat aaaatgaatt ttattatctt agttggggag gggagattac ctaactcccc 180360taaatgagtt aggtaatcta actcatttag ggtacctaaa tctttttatt ggaagtctac 180420acctgaactt gtctgctgtg gagcccctgg ggtgtatagc ttgaatatgg gggcagaatc 180480ccaaaattgc agcctgccta gcgagtatgc tacaggtcaa ggggtggact gttttcataa 180540gaaagtgagg tttcttagaa tttaaaaata gaggctgagt ggggcggctc acgcctgtaa 180600tcctagcact tttggaggcc aaggcaggca aatcacttga ggtcaagagt ttgaccagcc 180660tggccaacat ggcaaaaccc catctctact aataatacaa

aaattagcca ggcgtggtgg 180720tgcatgcctg tagtctcagc tactcaggag gctgagggag gagaatcgct tgaactcagg 180780aggcagaggt tgcagtaagc caagatcaca ccactctctg ggtgacagag caagattctg 180840tctcaaaata aataaacaaa taaataaata aaccagaagg aaaatagtgg ctgagggccc 180900agacctggag tcggactgaa cccgacttga ttcttgtctt taccccttta agcaaagtga 180960tagtgccacc ttgaacctca gtttacacat ctgaaaaatg ggtatactat tagttcccgt 181020gagaacagtt gccgtgagag ttaaatccaa ggacacactg tgtccatatg gtctgtgttg 181080caaaaagggt aacgtctttt tctcttgcca tgtttccatt gttggagctc tgcggagaac 181140caccataaag aaaagcaaga cagatttgct caaccccgaa gaggctgagg atcagctggc 181200tgatatagcc tctgtgggtg agtcccttcc tctgccacct atcagttgtt catcacctat 181260cgcccaagag acatggtggg gtgggggcag agggcttgca aaccgtgctg cctggatttg 181320ggtctcagct ccaccctttc ccacctgtgc gtgtgtcctg ggcagattac atcattatgg 181380gaataacatc cgtgcctagc ttctcattat tttgtgggaa ttcaactaaa tgatccccat 181440gaagcatggc aaaccagcac ctggcaggga cgaagctccc agtcaagttg gtgaatgttt 181500gtgactcatt cgggaagtat tcatggggga cctgcttata ttaggtgctt ggttgcaaac 181560aagacaaggc agtcacgagg ctgagctggg aggatcactt gagcctggga agtggaggct 181620gcaataagcc attattgtgt tactgcactc cagcctgggc acagaaaaaa aaaaaaagac 181680acaaactgag ccaggcacag tggctcacgc ctgtaatccc aacactttgg gaagctgaga 181740tgagcggatc acctgatgtc gggagttcga gaccagcctg gccaacatgg tgaaaccctg 181800gctctactaa aaatacgaaa aaaattagcc tgtagttcca gctactctgg aggctgaggc 181860gggagcatca cttgaacctg ggaagcagag gttgcagtga gctgagatct catcactgcc 181920ctccagcctg ggcaacagag caagatcctg tctcaaaaaa aaaaaaaaaa aaaagacaca 181980aaccaaatcc ctacctacat ggagctcaca gtccagtgca ggaaatagaa attaaacaga 182040gaattacaca aataaacctg taatggtaat ggcacttcag ggagaggctc tgggcttagc 182100ttgctctaga aggatgggga gcagtcaggg aaggctacct ggaggaagtg acggttaagc 182160tgggaactga aggatgggta ggagatcact gtggtggtga tagcagaagg aacagtgtga 182220gaggcagggc tcagaccttt gccaccacaa gggccagagt tcgagggagg agggaacatt 182280tattctttcc cttctcactc ctctgtccta ttgattcatt ggctgtgatg atgttgattt 182340tgaccttcta aagtgagaat gtattgttat tgttgttgtt gttctttaat gggtttttgt 182400ttttaatgga aggaagagca tccaggcaga ggaaataaga ctggaataag attgagggga 182460gaaggaattt aggctgcttg ggaaactgtg tggccgcagt ttagaggaag aaaggatggc 182520aagagaaaga ggaagggagg aagagaagga gggagagaag tgaaggaagg agggaagtta 182580gtacatccat gtgtttctga tccatagttt ctgatccact atttcgtatt ccccttttat 182640cgctcgcccc tagtttataa ccttattgct gagtttaggc ataatttcca ttgcgatcac 182700atatctcgta gggtggatac actatggttt gtttagccat agctctatta tagggtgttt 182760gagttgtttc caataatttc tcttacgaag aacactgctg tgcacattta cgtacaatga 182820ctccccccac cctttgggcg tatttccttg gggataatta taggatcaaa gatattaaca 182880gcttttcaac tcattattca aagagccatt ctgagtttca aaaacatgga acccatttat 182940aaacctgcca agtatgcata tgttcatgga ttccccaccc aggccatcga atattaccaa 183000tttaatttcc tttcccagtt aagtgggttt gtaatgaaac cttaaagctt gttttcattt 183060gcatttttaa tttccagcca aaacacgctt ttctttgtaa tggagaactc attctgcttc 183120cactcgtgtg tgcatctgtt taatttcctg taagcaaatg tcaagaattg gagcgctcag 183180taggtgtctt gagtatttga tcaattatgt ctgtctcacg tgttacgtta cctccattgt 183240ttaaaatctg ttttatgacg aggtacagtg gttcacgcct gtaatcccac tgctttggga 183300ggccagtgca ggaggatctc ctaagatcag ccgttcaaga ccagcctggg caacataaca 183360aggctccatc tctgaaaaac aaaatgttga aaaacttagc caggcattat ggcacacacc 183420tatagtccca tctatttagg aagctaaggc aggaggattt cttgaaccca ggaattcaag 183480gttgcagtga gctatgattg tgccactgca ctgcaacgtg ggcaacagag tgagaacctg 183540tctcttaaaa aaataaaata acatacattc ttaaaaatct actttgctgg ccgggcgcgg 183600tggctcacgc ctgtaatccc agcactttgg gaggctgagg cgggtagatc gcttaaggtc 183660aggagtagga gaccagcctg gccaacatgg tgaaaccgtg tctgtactaa aaattcaaca 183720attagctggg tgtggtggcg tgagcctgta atcccagcta ctcaggaggc tgaggcacaa 183780aatcacttga acccgggagg cggaggctgc agtgagctga gatggcgcca ttgccctcca 183840gcctgggcat caagagtgaa actccatcaa aaaaataaaa aatctgcata tacatatata 183900tgtatatata tttttaattt ttttaatttt tttttttttt tctgagatgg agtcttgctc 183960tagcacccag gctggagagc aatggtgcca tctcggctca ctgcagcctc cgcctctgtt 184020aacaaggcag gtgacattgc agctttctaa acagacccaa aacccaggcc agtggcttgt 184080tctttcatag ccacgtttgc tacaggcaaa tccaccaaaa cccacctcat cagcctgatt 184140actcaaaaag acaaagaaag gagcccccaa tctagccagt ggttttctag accaccccaa 184200aagagatctc tggaattcca ggattctggc aaggaatcac atttagcttt atttatttat 184260gtaaagaatg caacaataca ggctgggtgt ggtggctcac gcctgtaatc ccaacatttt 184320gggaagctga ggtgggagga tcgtttgagg tcaggagttt cagaccagcc taggcaacat 184380agtgagaccc tgtctctatc aaatattagc tgggcattgt ggcacacgcc agtagtccca 184440gctactcgtg aggctgaggt ggatcacctg agcccaggag gtcaaggctg cggtgagcca 184500cagcatgccc ctgcactcca gcctgcgtga cagagacttc atctcaaaaa aaaaaacaaa 184560aaaaagtaat aatacagtaa tgcatatttc aaagtaaggt gggagctatg tggtatttgc 184620gttcacgttc acattatacc acagtatgca cagtcctttt tttttttttt ttgagacagt 184680gtcttgctct gatgttcagg ctggagtgca gtggtgcagg catagctcac tgcagcctca 184740aacccctgga ctcaagtgat cctcccacct cagcctccca agtagctggg actataggtg 184800tacactgcta cactcagcta agttttttat attttttact agagatggga tctcaatatg 184860ttgcctaggc tggtctcaaa ctcctggcct caaacaatcc tcctacctcc acctcccaaa 184920gcagtgggat tacaggcgtg agccaccaca cctggcccac atgcagtctt atataattgg 184980tgattctact gcgctgttga atcagttgat aaacgcacta taaagcaggt tcattcctaa 185040ttgatgaact tactgctgaa ataaggaact tgaatcattt acatgaaaag ttgagccatg 185100ttgctgaaag gatatcaatt tttttttctt ttttttcttt ttttttgaga tggagtctta 185160ctctgtcgcc caggtgggag tgcagtggtg cgatctcggc tcactgcaac ctccaccttc 185220caggttcaag cgattctccc acctcagcct ccaagtagct gggactacag gtgcacacca 185280ccacgccctg ccaatttttg tactgttagt agagatgggg tttcaccatg ttggccaggc 185340tggtctcaaa ctcctgacct caagtgatct gcccacctca gcctccgaaa gtgctgggat 185400tacaggtgtt agccaccgcg cctgacagga tatcaaattt catttagact gcaggaatac 185460gttcaagaga tctattttgt acagcctggc gactgtatta ataacaatgt attatatact 185520tgaaaattgc tcagagagta ggttttaagc attctcaccg tgagaaaagt gataagcata 185580tgtaataatg catatgttaa ctagctcaac tgagccactc catagtgtat acatatggtc 185640aaaatatcat gttatgcact ataaatagat acagcctgta tctgtcaatt taaaataaat 185700gaataataac tttaaaaaga aaaataacag tatggctggg cacggtggct cacacctgta 185760atcccagcac tttgggatgc caagacaggc ttgaggccag gagtttgaga ccagcctggc 185820caacatggcg aaactttgtc tctaataaat atacaaaaat cggctgggca tggaggcggg 185880cgcctgtaat cccaactact tgggaggcag aggcatcact taacctggga gatggaggtt 185940gcagtgagcc aagatctgca ctccagcctg ggtgatagag tgagccttta tttatttctg 186000taaagaatgc aataatacag gcctggtgcg gtggctcatg cctataatcc caatgttttg 186060gaaggccaag gtgagaggat catttgaggc tacaggcgca tgccacagtg cccagctaat 186120acttgataga gacacggtct cgctatgttg cccaggctgg tctcaaaacc ctggcttcaa 186180atgagcctcc caccttggcc tcccagagtg ttgtgattac aggtgtgaga cactgtacct 186240ggcctgtatt aaaaaaaaaa aaaagaagaa gaagaagaag aggaggaaag aagaagaagg 186300aagaaggaag aagaagaaga ggaggaggag gaggaatggg aaggggaagg ggaagaagaa 186360gaggaggaag gggaagggga agaagaagag gaggaggaag gggaagggga agaggaagaa 186420gaagaggaag aagaagacga agaagaagca caatgataaa taagtaaaat gtggagcata 186480tgaaaacaaa acaaaaaaaa gttgatccat tatgaatgga agctgccatt gtaactctgc 186540ttttttagga aaaccagacc ccatttagat gattttattt gtttttaaag gcaggttctt 186600gctctgtcac tcaggctgga gtgcagtgat atgatcatag ctctctgcag cctggagctc 186660ctgggctcag gcgatcctcc cagcttagcc tcccaagtag ctgggactac aggcaccacc 186720acacccagct aatttgttgt tgttgttgat gttgttgttg agatggggtc tggctatgtt 186780gcccaggctg gtctcaaact cctggcctca agtgatcctc ctgccctggc ttcccaaagt 186840tctgggatta caggcatgat tttttattaa tttatttgca gctgacaaat ggtaattgtg 186900tatgtttatg gagtgcagtg tgatgtttta atctatgtat acatcataga atgattcagt 186960catgctaatt aacacatcca tcgcctcacc acctcaccgt tttttgtgtg tggggaaggc 187020attaaaaatc tcttagcaat tttgaaatat gcaacacatt actatttatt aataatgcaa 187080tataaataca caataatgta ttaatgcatc actaaatgcg atgcaatgca atgcaatgca 187140atagatcact aaaacttact cctccagtct aactgcaact tatacccttt gatcaacatc 187200ttctccttct caatccctcc tcctcccctg cagcctccag gaaccacctt cctgctcttt 187260ctatgagatc aatttttttt agttttaagc tcccacatgt gagatcatac tgtaattgtc 187320tttctgtgcc agcttatttt actcagtata atgtcctcca gttctgtccc tgttgtcaca 187380cattacagaa tttctttctt ttagggctgt atagtattct atttgtatac ataccacatt 187440ttctttatcc attcatccat tgtgggacac ttagtttgct tccatatttt ggctattgtg 187500aataatgctg aagtgaacgt gggagtgcag atgttctgaa aagacttaaa tgtcagacct 187560gaaatggtaa agatgctcca agaaaacata aggagaaagc tccatggcat tggtctcggg 187620aatgattttt tggacaggac ctcaaaagca caggcaacag aagccaaaat ggacaaatgg 187680gatcgtatca aactaaaaaa tttgtgcaca gcaaaggaag cgttcagcag aggaaagaga 187740caacctaagg aatgtgagaa aacgtttgca aacaatacat ctgataagga gctaatatcc 187800aaaatatata aggaactcaa acaactcaac agcaagaaaa caacccaatt aaaaatgggc 187860aaagacagct actcgggagg ctaagatgtg acgatccctt gagcccggga ggaggaggtt 187920gcagtgagct gacattgcat cactgcactc caccctgggc gacagaagga gaccgagacc 187980ctgtctcaaa ataaaaaata aaaatgtgca aaggatctga acatacatat cccaaaagaa 188040aagacataca agtggccaac aggtatatga ataaaatgct gaacatcact catcatcagg 188100gaaatgcaaa tcaaaaccac cattagctat cacctcacac ctgttagagt agctattatc 188160tttttgtttg tttgtttgtt ttttgttttt tgttttgttt ttgagaggga gtctcactct 188220gtcacccaag ctggagcgca gtgttgtgat ctcagctcac tgcaacctct gcctcctggg 188280ttcaagggat tctcctgcct cagcctcccg agtaactgaa attacaggca cacgccacca 188340tgcccagcta acttttgtat ttagtttcac tatgttggtc aggctggtct tgaattcctg 188400acctcaaatg atctgccctc cttggcctcc caaagtgctg ggattacagg tgtgagacac 188460tgtgcccagc ctagagtagc tattatcaaa aagacaaatg aggtttgttg aagttctaac 188520ccctggtacc tgcaaatgtg gccttacatg aaaatagggt ctttgcaggt ggtaatcaag 188580ttaagatgag atcaaactta attagggtgg gtcctaaatc caatgactgc tgtctttata 188640agaggagaag caggctgacc aacatggtga aaccccatct ctactaaaaa tacaaaaatt 188700agctgggtgc agtagtgcac acctgtagtc ccagctactc aggaggctga ggcaggagaa 188760ttgcttaaac ccaggaggtg gaggttgcag tgagcagacg tcatgccact gcactccagc 188820ctgggtgaca gagtgagact ccatcttaca agaaaaaaaa aaaagacaaa tcataacaag 188880tgctggcaag gatgtgggga aacggggatc catttacatc attttaataa cacaggctct 188940atatgggtgg tattgagttc ccagagttgc cattacaaaa tgtcacaaac ccagtggctt 189000aaaacaacag aaatttcttc tctcacagtt ctagaggcca gaagtccaaa ctgaaatcaa 189060ggtgtcagca gagccaccac gttccctcag aaggttttag gggagaatct gttccatggt 189120attttcttag tttctggtgc tgccagcgat acttggtgtt cctcagttca tagatgcata 189180attccagtct ctgcctctgt tgtcatatgg tcttctttct gtgtttctgt atgcgatttc 189240tttttttttt ttttttttct gagacaagtc tcactccatc acccaggctg gagtgcaatg 189300gcacgatcac agctcactac aaccccaacc tcacaggctc atgccgtcct cccacctcag 189360cctcccgagt agctgggatt acaggcgtgt gccaccatgc ccggctaatt tttgtatttt 189420tagtagatac ggggtttcac catgttggcc aggctggtct cgaactcctg accttacgat 189480ctgcccatct cggcctccca aagtgttggg attacgggca cgagcccacc gcacctggcc 189540ctaattactt tatttttttg taaatttttt tttgtaaatt tcatgtagcc tgagcataca 189600gtgtttataa tatatacagg agtgtacaat aatatcctag gccttcacat tcactcacca 189660ctcaactcac tccctcacca agagcaactt ccagtcctgc aagctccatt catgccaagt 189720accctatgca gctgaaccac cttttctctt ttatactgtg tttttactgt accttttcta 189780tgtttagata tgttcagaca cacaaatact atgatgttac agttgcctac agtattaagt 189840acagtaacat gctgggcagg tttgtagccg aggagctaca aaccacgtag cctgggtgtg 189900gagtaggcta caacatctag gtttatgtaa gttcacttta agatgctcac acaaggacaa 189960aattgcctaa caatgcattt ctcagaacac gtctccctca ttaagccaca catggctgta 190020ttacaattta catataattt taagcgtata taaattgcca gaaatcacca gatgaatcct 190080tggcggtgac ataccccttc ccccaccata gaacattgca gactggcccg gacgcccagt 190140atctcatgcc tgtaatgcca gcactttggg aggctgcagc gggcagatca cttgaggtta 190200ggagttcgag accagcctga ccaacatggc aaaacaccat ctttactaaa aatacaaaaa 190260ttattcggac gtggtagtgg gcacctgtag ttccagctac ttgggaggct gaggcaggag 190320agtcacttga acttgggagg cagaggttgc aatgagccaa gatcgtgcca ctgcactcca 190380gcccgggtga cagaatgaga ctctatctca aaaaaaaaag aaaaaaaaaa aaaaaggaaa 190440agaacatttc agactggtac cagttacacc ggctcttgat cccttgaatg tggctgaccc 190500tgaactagga tgtacttcat aataacacgt ccggctggga atacttagta caaaagaaag 190560agtataaaat atcttttgaa tccaccttga tattgattcc atgttgaaat ggtaatattt 190620tggatgtatt gggttgaata aaacatctca tgaaagtgat ttttaaaaat ctagaaattg 190680tctgcaatta taattccaga ccacagagaa aaacgagaga caggaatgta tagaaaaagg 190740gaacgtggga caaagtgagt atgaaattca actaacagaa gtgacagtgc ctagcatggg 190800gtccagcact tagtaggtgt tcaattaata ttcatttccc tctcccttac cagtgaaggg 190860tatgcctgtc gtggggaatg tgtcttcagg ctgagtgatc aggaaggact ttctcaatgg 190920ctggcacgtg aacctagtca tgatttcagc tcttgaggtt gtactagaag atttatatcc 190980aataatcgta aggtaccact tagcatcacg ctaagatgta ttaattcatt tatgcctttg 191040gatggccctt tgaggtagga agtgtggttg tctccagttt accaaggtgg cttgcccaag 191100gtcatctgct ggttggtgat taagccaggt tttcagtgtg gctccagcag gagtgggggc 191160tggggacctt ctacctgctg tggtttctct ctctctctct ctctctctct ctctctctct 191220ctcgatctgt ggaacatccc ccctgtcccc caaggtccca agggtcttat ttcttttggc 191280caagcccttt ggagacctgc agatctggac acatctttga gagtttcagg aactagggcc 191340agaaatgctg ggcagggtca tgaggagctg ccactggggt tgagaaggtg atggacatga 191400ggggaagggt ctttgcagaa aggagaggcg tccctgtaag caggtcacag ccactgggcc 191460tggccaactg cagccgagtg gaatgtgccc ctgccccatg accatatgcc ccaggtgtgc 191520aatgtggcgg cccagagcac acactctgaa ccatcttgac acatcttcac tggttactag 191580acccccctca gcctgtttcc ttggctgtaa aatggggatg acgctggtcc ctacttccta 191640gggctctgag caggagtaag tagcttgtcg tataaaacat gttccctgca gtgcctggtg 191700cctgctaaat gttccataaa cgtcagctgt tattttcatt caggggaagc tgaaatccat 191760attttcatgg aaaatctccc agtttttaaa tgtggaccaa taatttcagc tttcacaaac 191820ccagtatgag tcggtatggc ccctagggtg ccaactcaaa atctctgttg agaattttgc 191880tgataggaag tggcctcctt ggaggtgttt gctgtgtcct gtgtctggca agtggggtgg 191940ttttgataaa cgtgctggat ggatgtatgg gtgaatggat aaatggagga atgaatggag 192000aaacaaatga gcaaatgaat aatgaatgga tggatgaatg gatgagcgaa tggatggatg 192060aatggatgag caaatgaatg atgtacacac aaaggaatgg ataaatgatg aatgtgctaa 192120tgaatttaag aatgatgaaa gaatgaatga ataaatgaac aaatggatgg atgaaagaat 192180gaatgaatgt actaatgaat gaatcaatca atgaagaacc atttaaaaat gaatgcaact 192240gagggtttat aagaaaaggt atcttaagcc tgggcatggt aattcatgct ggaatcccaa 192300tgcttaggga cgctgaggcg ggaggatcgc ttgaacccag gagttcaaga ccagcctggg 192360caacacaggg agacctcatt gctaccaaaa acaaaattgt tttaattaag cgggcatggt 192420ggtacgtgcc tgtagtcata gctacttggg aggctgaggt gggaggatcg cttgaaccca 192480ggagttcaag gctgcagtga gctaggatca agccactgca ttccagcctg ggcaacaaag 192540caagatcctg tctcaaaaaa aaaaaaaaaa gatgtatttt agaaggtaaa ttcaatctgt 192600ccaaaactga gctctgacct tcccctaaac ctgtgcccat tcagtggatg agagctccat 192660cccttaaggg gttcaccaat tcatccattc ctttgtatgt acatcattca ttcaccttgg 192720ctcatccctc tctcttacat ccacaccgtt ccatcagcaa atgttgaatc tgtcttaaat 192780gattcatccc aaatcctccc cgcttaacta ccacccaact ccagccccca tccatcatca 192840tcatcacttg cctggatggg ttcagtcacc tccagcctgg tctcccagct cccgtcctca 192900cctctcactg tctactctcc cactcggcag ccagagggtg cctgtgaaca cccaaatcag 192960gttccatccc tcctctactc agaaccctcc acggctcccc cctcactcag ggtaaaagcc 193020aaagtcctcc ttgtggtcca ccaggccatg catgatctgc ctgtcacctc cctgccttca 193080ccaccttcct cttttcccct caaccactcc actccagcca cactgacttc cttgtgctct 193140tccccaaaaa tgtcgggcag acacattcat gcttcaggac cttaaatttg ctgtttcctc 193200tacctaagat actaaagtga caagtcaaca cactcacctt gaccatgcaa tttaatgttg 193260cagcctaccc tgtggactct ccaagggctc ccagtccctc tgtgatgctt tactttttct 193320cttaaaaaaa aaattgttat ttaaaagaac ttgtctcgct gtgttgccca ggctggtgtc 193380aaactcctgg cctcatacag tcctcccatt ccagcttccc aaagtactgg gattagaggc 193440atgtgccact gcacccatcc caactttttt tttcccatag cacttttcat tttccatccc 193500actgttaatt tacttattac gtccactgtc tgtctcctcc ccttagaggg tcagaccccg 193560gaagtccagg ctctgttgcc taatgtatcc tgagcccctg gaacagagcc tggcacaaaa 193620taggtactca ataaatgcat aagagcaaaa ctatatgtag gcagaggaca cacccagctt 193680attcctcagt gatcacttct aaagttaaat gtccatggaa aacagtctca tccacatctc 193740tttctggagg ccttccaagc gtgctccatg cagctctgtt gcctgcccct gcatcaggga 193800atggaggctc tgctttatcc tgccctgtgg tgtgactccc agaggcatca gatgtggctg 193860ggagtgggag acatggaaaa ttggctcctg caacagagaa ctatcagcct tcccatcaat 193920tggttacttc taattctgtt atttttcagg ggcactgtct tctcataagc tccatctatg 193980caaaactaag cccatgggtc atgatggttc cctcaggcca gaggcttgct ggagagacta 194040atggatcccc tggctaaaat ctgtgcttgg gctgcacatt ggttaatttc ttctgaagga 194100acagcctgag cctgacattc tccatctttt ccctggcagg ttctcccttc gcccgagcca 194160gcattaaaag tgccaagctg gagaactcga ccttttttca caaaaaggag aggaggatgc 194220gtttctacat ccgccgcatg gtcaaaactc aggccttcta ctggactgta ctcagtttgg 194280tagctctcaa cacgctgtgt gttgctattg ttcactacaa ccagcccgag tggctctccg 194340acttcctttg tgagtatcac ccagccccac ccctgccaac tccctgatcc ctccctcaca 194400ccctttttcc acttctcttt ctctggtagt atgtgtatct tctttggtcc tcattgaatc 194460tgccctttcc tttagccatt tctataactg tcactggggc caatgttact gttgctatga 194520caatggaacc catctccctt agacctgaga gctggaagct ggaattcaga ccaacaaatg 194580ctcctgtgat tcctttctaa gagagaggga cagaggggtg ctggtgaagg ggatgttgga 194640agagagacag agaaagacgg agctcataag atagacagat agaaacagaa acatacatgt 194700attaataatt tttatgtaca tctctggaaa tgttcataac ttatggttaa gagaggatgc 194760cttagaaata aggagtggct tatatgttgc cctcattttc tctacttatt tctgactcta 194820cttctctctt ctttcaaacc ttctgcttct ttcctgttag gttggtgcaa aattaattgc 194880gttttttgcc tttttttttt ttttttttaa ccacagttac ttttgcacca acctaatact 194940tcctcccctg ccctttttgg cttccttatt cattcataga acatcccctc cagtatctgc 195000gagagcgttt tgctccctca aggtacaagg cccactaagg ctttgccctc tgggcctatt 195060cccagattct atgtgagtta gcatgagata gtatcaaaat tgagggccaa gtgagggtga 195120ggaaaagcag caaaagatgg ggagatgtct gagcaggatt taaaaagtaa agagctcgag 195180gaatcaacaa gagcagcgac tggggccagg catggtggct cacacctgta atcccagcat 195240tttgggaggc tgaggtgggt ggatcacttg aggccaggag ttcaagacca gcctggccaa 195300tatggtgaaa ccctgtcttt acaaaaaata caaaaattag ccagatgtga tggtgcacac 195360ctgtaatccc agctactcag gaggctgagg cactagaact gcttgaatcc aggaggcaga 195420ggttgcagtg agccaagatc atgccactgc actccagcct gagcaacaga gagagtgtct 195480gtctcaaaaa ataaagtaaa ataaaataaa ataaaataaa gagtagtgat tgggcagtga 195540ggggggcagg tggatgccct ggctttggct cacaggcccc aagtaaggac ttctcaaaac 195600gtcttttgcc tactggctgt ctaatttatt cactgacctt ctgacctggt tcagaattga 195660cttaggacag caagaagaga cagtctagtc tttgacctag aaaggcccgt gagcctagtc 195720caggccattg tcttcttata accctccttg ttcccagtca

cgttggctga ccccccagga 195780cacccctcag gaaccagttc tccttcccag ggccctgacc tagtttcaaa cttagtaatt 195840gtttttagtc cctctggagt ctcttataaa tgaggactct acttcgtgtt ttaacttcct 195900ctaatactct atttttaatc tcctatattc tctctactaa tcatcttgta cagtctgtcc 195960tggttcagga acaagggact gagacttcct gcctgggtcc tcagtgtcta taaaggtcct 196020ttactcattc ccactttccc tttgagaaaa ctgagacaca gagaggttaa gtagattgcc 196080caggatcaca cattagcttg gcatgatggc gggcgcctgt aatcccagct acttgggagg 196140ctgaggcagg agaatcgctt gaacctggga ggcagaggtt gcagtgagcc cagatcatgc 196200cactgcactc tagcctgggc aacagagcta gacgccatct caaaaaaaaa aaaaaaaaaa 196260aaaagataca cattaatttc agagatgtca aaatataaac aaaaatgtat atcttggcat 196320cagtgaagtg tagttgtttc tctggatctc agactccaca tctatgtggt agaaaccgga 196380tttgatggtc ctgaaagttc ttccagatgc aacaatgcta aggataagta attctttcaa 196440gtcttgtgca tcacctgcta tcatgtttcc atggtaactg aggaacaaga tctcagaaac 196500tcttcagtcc tcccagagtt acttctggtg ggtctaggaa tgtgtcagat gttacaaaca 196560gacttcctct gctgatattt tggtcctagg aaccctagag ttcccctcag acactaagat 196620ctccttagcg tcctataaat aaggagaaat tttggtgata aatactgtga aggactttga 196680cggtcagttc aaaacacctc ttaaaagcat gacatagcaa acacccttgg caaatatctt 196740agttcatttg tactgctata acaaattacc cgagactggg taatttgata agaacagaaa 196800tttattttct cacagttctg gaggctggga agcccaagat caaggcattg gcaggtttcc 196860ctgtctggcg aaagctactc tctgcttcca agattgcacc ttgaacactg tatcctctgg 196920aagggaggaa cactgggtcc ttacatggca gaaggtggag gagcaagagg gacaaacttc 196980ctctgtcaac ctcttttata agggcaccta atcccattca tgagagctct accgtaatga 197040cttaatcacc tcctgaaggc cccacctctt aatactgtta cattggcaat taagtttcaa 197100cgtgaatttt ggaggggaca caaacattta aaccatcaca accaccaaac acaattagct 197160ttgtggcctt aattagctat atgaaattca tggaagttag tttcagtcct ctgtctcttt 197220cctttctgta tgctttctgc tcctcagaaa ccctcctcat ctctcctttc tatccattaa 197280gtacccacgc ccttcctaac tcctcatctt cctaccctac caagaaagcc ctctcagaaa 197340aggatctgat gtcagccatt tatttgctgg agcaaatgca tatccatgtt ttacccctcc 197400ctgaggcatt tgcaatttta tgcttgctca tcaaagaaca aaaggctttg tcttactcaa 197460gactttttag gtcactcaca acacaggatt tctaggggac ataagacaag ttttctgagt 197520taggagaaaa gccatacctt aggtgggttg cctgtgtcgc tccaactaag tacttaactt 197580caggattaca aataggatat cattatgatt tctatttcct tttatccttt ggagctcagt 197640cacgtagaag tagattaaat ataattgtta gatcacagca ccctggcatt atggggccgt 197700tatggtccat tgttattatg tgaattattc agttaattag tttatttttt aaatgtgata 197760aacacccagg aacccaccag tcaacacaaa agtccttggc aataatctat atccgatcct 197820tctcatcgaa ccagggcaaa aactacaaga tggagaccca ctgatatttt tctcattcct 197880tttaaaatcg gcctaaggtt ggttagcttg ttggttggag ggtagggcat aattgttgct 197940tttttttttt tttttttttt ttagacaagg tcttgctctg tcacccaggc tacagtaggg 198000tggcccaatc ttggctcact gcaacctcca cctcccaggt ttaagtgatt ctcatgcctc 198060agcctcccaa gtagctgggt ttacaggcat gtgtcaccac actggctaat ttttgtattt 198120ttagtagagg cggggtttgc catgttagcc aggctggtct caaactcctg acctcagttg 198180atctgaccgc ctaggcctcc caaagtgctg ggattacaga cgtgagccac catgcccagc 198240cagctcttcc tttttaacag aggggaaact gaggcccatg ggaaggacac cttggacagg 198300gcgtggccac agtgggtcat gtatataatc ccagcacttt gggaggctgt gctgggagga 198360tcacttgagg ccaggagttc aagaccagcc agggcaacat agtgagaccc ccatctccac 198420ataaaaattt taaaaagaaa aaagataagt cagaagttgg gtgtggtgac acatgcctgt 198480agttctagca tgttggaggc caaatcaggg aaactgtttg aggccaggag tttgaaacca 198540gcctaacagc atagcaagac ctcatctcta caaaaaataa aaagtttaaa aatgataata 198600aaaggaaagt cagagccacc tggaacccct accctcagca agcctaacct cctctctgtt 198660tcctccttct cccttctaga ctatgcagaa ttcattttct taggactctt tatgtccgaa 198720atgtttataa aaatgtacgg gcttgggacg cggccttact tccactcttc cttcaactgc 198780tttgactgtg gggtaagtgc tcttgtttct aagagttcat ttctccagct cttgcctgga 198840atgacagata cctggacaca ttaaagggag aaaggtaaag tcacccctga atatgagaga 198900ctcagatgga tgcagaagga atgagaaaac aatcccaaac actggcaagg atacagtgta 198960cccagaaccc tcaaccaccg ccagtgggag gaaaacgtat agaccccctt tggaaagcta 199020agtgggggac ataagacaag ttttccaagt tgggagaaaa gccatgcctt aggtgggttg 199080cctgtgtcgc tccaactaag tacccaactt caggattaca aacaggacat caatatgatt 199140tctatttctt cttttccttt gtagctcagt catgtggagg tagatgaagt ataattgtta 199200gattacaaca ccctggcatt atggagccat tatggtcctt tgttattttg tgaattactc 199260agttaattaa tttatttttt aaatgtgatt aacacccagt aacccactag tccacacaaa 199320acctaagtcc tggagaataa tctacgtcca atccttctca tcgaaccagg gcaaaaacta 199380caagatggag atatgaccca gcattccatt gctaggaatt catcctagaa aatctcaccc 199440agatacctag gagacacagg ccagaatgtc cctgcagctg gaagtgaaat taaggttgtt 199500cgcaaataag tggagaatgc ctggcccagg gcagccctaa tcatttacca tagtcctgtt 199560ggtctcagaa aggcttaata atttatttat ttttttttat tttttgtttt tattttttgt 199620ttttgagatg gagtctcgtt ctgtcaccca ggctggagtg cggtggcgcc atctcggctc 199680actgcaagct ccgcctccca ggttcactcc attctcctgc ctcagcctcc cgagtagctg 199740ggactacagg tgcccgccat catacctggc taattttttg tatttttagt agagatgggg 199800tttcaccgtg ttagccagga tggtcttgat ctcctgacct cgtgatccac ccgccttggc 199860ctcccaaagt gctgggatta caggcgtgag ccaccacacc cagccagctt aataatttat 199920aataactgaa tgttgtactg ttttctgcca ttatagaaaa ttatgttgtt ggagaaaaca 199980aaatacatac aaacaagcaa accttcccta cataaatgac ccaagtagtt aaagaataaa 200040accaatttct ttccattaaa aagaaaagaa agccgggtgt gatgcctcat gcctatagcc 200100tcagctattc aggaggctga ggcagcagaa ttgcttgagc ccaggagttg aaaaccagcc 200160caggcaacat agcaagaccc tgtctctaca aaaattaata ataattagcc aggtgtggtg 200220gtgcacacct gtagccccag ctactcagaa ggctaaggtg ggaggattgc ttgagcccag 200280cagtttgagg ctgcagtgag ctatgatcac accactgccc tccagcctgg acaagagagt 200340gagaccccat ctctaagaaa taaaagtagg ccaggcacag tggctcacac ctataatccc 200400agcactttga gaggcggagg caggtggatc acctgaagtc aggagttcaa gaccagcctg 200460gccaacatgg cgaaaccccg tctatactaa aaaaatacaa aaattagcca ggcgtcgtgg 200520cacatgcctg taatcccagc tacttgggag gctgaggaag gagaatcact tgaactgggg 200580aggcagaggt tgcagtaagc tgagattgca ccactgcact ccagcctggg tgacagaatg 200640agactccgtc tcaaaaaaaa aaaaagaaaa attttaaaat gtcctgagca accttgtttg 200700taatagttcc aagtctcaat atccgtgtat ccctttgctg tagaacagat aaatattttg 200760tggcatatct atataatgaa atactctgtg acaatcaaag tccaccaaca gcagccacat 200820gcccaacaac aggaatgaat ctcacccatg taacatggca cagaaggagg caggagctag 200880caacgtaagt ccatacagtt catgcaaagt tcaagtggac aaaattaaac tctctctctc 200940tctctacata tatatatata tatatatata tttttttttt tttttttttt tttttttttt 201000ttttttgaga cagagtctca ctctattgcc caggctggag tgcagtggcg caatcttggc 201060tcactacaac ctccacctcc cgggttcaag ccattctccc gcctcagcct cccaagtagc 201120tgggattaga ggcatgcacc accacccccg gctaattttg tattttttgt agagaccggg 201180attcagcaat ttgcccaggc tggtctcgaa atcctgatct caggtgatcc acctgccctg 201240gcctcccaaa gtgctgggat tacaagcgtg agccaccacg ccccgcctta aactgtattt 201300tttaaggatg atacttgaat acgttaaaaa ggcgaggacc ttgaaaacac aacgctcggt 201360aaaagaaacc aaacacaaaa ggtcaagtat tgcataattc catttgtatg aaatgtccag 201420agcaggcaaa tccatagaga cagaaagtag attagtggtt gctagggtct gggtgaggga 201480gagtggggag taactgctca tggggacagg gcctcctttg ggggtgatga aaatgttttg 201540gaacttgata gaggtgatag ttgcagaata ttgtgcatgt acctaaaggc actgaattgt 201600gtaattcaaa gtgtgaattt tatgttatgt gaatttcacc tcagtttttt ttaaggtaag 201660aaaatggtta ttacaaaatt caggatggta gttatatcac agtgtctctg gaaacttcca 201720gggtatccac atgtcccttt ttattttatt ttatttttta ttttatttga gatagggtct 201780tgctctgttg cccaggctag agtgcagtgg caggatcatg accctctcct gtctcaaatt 201840cctaggctca agctatcctc cctcctcagc ctcctaagta gctgggacta taggcacatg 201900ccaccatgct tgactaattt tttttttttt tgtaaagtca gggtttccct gtgttaccca 201960ggctggtctt gaactcctgg gctcaagtga tctgcccacc tcggcctccc aaagttccag 202020aattacaggc atgagccact gccctagcct tctcctaatt gttgacatag gtagtagttg 202080catgacattc actttgtaat tatgtgtttc aggaattctc aggcctgtgg gagctcttaa 202140taaataaaaa agaggccagg tgtggtggct cacgcctgta atcccagcac tttgggaggc 202200cgaggcaggc ggatcacgag gtcaggagtt cgagactagc ctggccaaca cagtgaaacc 202260ccgtctctac taaaaataca aaaaattagc cgggcgtggt ggcgggtgcc tgtaatccca 202320gttacttggg aggctgaggc aggagaatcg cttgaacctg ggaggcggag gttgcagtaa 202380gctgagatcg cgccactgca caccagcctg ggtgataaga gcaagactcc atctcaaaat 202440aaatgaataa ataaaaataa ataaataaat aagaggccgg gtgcagtggc tcaatgcttt 202500ggaaagtgga ggccaacagt tggagagacc aaagcaggag gatggcttca gcccagaagt 202560ttgaggccag cctgggcaat actagcgaga cactatctct ataaaaatgt tttaaaatta 202620gccagatgtg gtggggcaca cctgtaatcc cagctactca agaggctgag gtgggaggat 202680cacttaagcc caggaggaca gtgctgcagt gagctatgat tgcgccactg cactccagcc 202740tgggtgacac agtgagaccc ggtctctata gataaatgaa tggatgaatg agggggtcaa 202800ggatcctcac ccggcttcca tttggaggga ggagtttggt tgagttcttg caaggttggt 202860acctaggaaa tgcttgccag ttctggagcc cagacactgt ccctggacat gagaccaggt 202920tctctgccct aggttatcat tgggagcatc ttcgaggtca tctgggctgt cataaaacct 202980ggcacatcct ttggaatcag cgtgttacga gccctcaggt tattgcgtat tttcaaagtc 203040acaaagtaag tctttggggt tcctggacat ttgtacaggg ggtggggatg ggggacatgg 203100tggggccgcc tccagaaagt tgggaaagtg agcctcgtgt ttcgagggct gactccgggg 203160ccctgcctcc cccgcctggc ctgagtcctc gcctggcctc tgtcggcagg tactgggcat 203220ctctcagaaa cctggtcgtc tctctcctca actccatgaa gtccatcatc agcctgttgt 203280ttctcctttt cctgttcatt gtcgtcttcg cccttttggg aatgcaactc ttcggcggcc 203340agtaagtcct tcacaggaat tccaactcct ggttccctgg ggtcaggctc agggaacaca 203400cagtcccctc caccgtgcag gctgccttcc tcgtagccca gacacccatt gcggtcaccc 203460aaatgggcag ggccctgggt accactcagg gtttcctggg gacagagatg atggagacgt 203520tcgtttcctt ggagatgaga tactgagcca caccctcaga gcaccccggg tggggccaac 203580gtgaaatgtc tgtgtcctcc ctgcaggttt aatttcgatg aagggactcc tcccaccaac 203640ttcgatactt ttccagcagc aataatgacg gtgtttcagg tacagcctcc acctggcccc 203700acgggccaac acctctcagt gtcacagatg aaagtgcctg ctccacatcc aaggggcttc 203760cctgaactcc tccttctcta cctggccttt tcacaccact ttgaaacaca gattttatgg 203820ttatcattat tcaattatgg tgaggccaac agatcaggag atgaatgtca ttggaaagat 203880agtttgtggc tgggcacggt ggctcacacc cataatccca gcactttggc caggtacggt 203940ggctcacacc tgtaatccca acgctttggg aagcccaggt gggcggatca cttgagatca 204000ggaattcgag accagcctgg ccaacatggt gaaaccccat ctctactaaa aatacaaaaa 204060ttagccgggc gtggtagcac atgcctgtaa tcccagctac tcgggagatg aggcacaaga 204120attgcttgaa cctgggaggc agaggttgca gtgagccaag atcgcgccac tgcactccag 204180cctgggcaac agagtgagac tccatctcaa aaaagaaaaa gaaaaaaaaa accactttgg 204240gaggtcaaga tgggaggact acttgaggcc aggagtttga gacaagtctg ggcaacatag 204300tgagactccg tctctgcaaa aaaataataa taataattag ctgggcatgg tgatacatac 204360ctcctagcta ctagggcagc tgaagtggaa ggattgcttg agcccaggag gttgaggctg 204420cagtaagcta caatcacacc actatactcc agcctgggcg agagagcaaa gccctgtctc 204480aaaaacgaaa agaaagtttg ttatactcac agatcctcag agaaggagca caccatgcag 204540gaccaagcag agaagcaaca gggtcaagca ggaagagaag gaaaatgtgg gcaagaggct 204600tgattgtggt ttccatggga cggaatgggt gaggcagagt aaacagctcg agactggcta 204660gtttggatca tttcagtggg ctctggggca gaggagctgt tcctacttgt ctaggacctg 204720gccttggggt gattagggca ggtggatagt gctgggaaga taaaggaggt ggttgggata 204780tgggctggtt gggatattgt ttggtttgct tttaaaaagc ctgctcaggg ctaaattgtt 204840tactacctct agggactggc tagtgctgga ccgggcagtc cctccagagt cagcaagacc 204900ccagatgcat cagaataaag aaaataaaat gcgtggccag gccaatgagg tggttcatgc 204960ctgtaatctc agcactttgg gagaccaagg cgggaggatt gcttgagccc aggagttcaa 205020ggctgccgtg agctccagcc tgcaccacag agcaaggccc tgtctcttaa aaaaaaggca 205080gagaaaaaaa atggctaata cacccatcaa atctgaagat accttggtct catattccag 205140ggtgatcaac ccaaagcaac ttctgcaccc atgtgggcgc attccctgag gcttgggact 205200ggcccagccg ggaccttcag agcatctttg gtggattctt tctctttgag ggactgagag 205260tgtatagaaa atgtgacttc actctctcct tctcctgggg aggtagtttc taaatgagac 205320cccaagacag ggagttgaag aggaaacctt ccatgaaggg aagttctgag cccccacata 205380agcgattttt tttttttttt tgagatggag tctcgctctg ttgcccaggc tggagtgcga 205440cggcacgttc ttggctcact acaacctctg cctcctgggt tcaagcgatt ctcctgcctc 205500agcctcccga gtagctgaga ctacaggtgc atactaccat gcctggctaa tttttgtatt 205560tttagtagag acagggtttc actatgttgg ccaggctggt ctcgaactcc tggcctcgtg 205620atctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccac cacacctggc 205680ccataagcga ttattaatag cactgatcgc tagtcatgta tctttagctc agaggttctc 205740acccaaggac aagtctgtcc tccaaggaca tgtagcaatg tctgcaagca ttgttggttg 205800tcacagctag ggagagggtg ctactggcat ctggtgggtg gagactagga atgctgctca 205860atatcctaca atgcacagga cagccccaaa tagaataatc tggccccaaa tatcagcagt 205920gctgaggctt agaaaccctg ttttagcaga ttcatgtttt tggagttctt taacatttac 205980tttatcctca tggggatatg gatagaagga aggaagttgg atctttttta aaggagcatg 206040taggtgctgt ttgaatatcc ccttggttct ttcagtatgc atcagcacaa cttgcgtctg 206100tcaacaccta atcctttgcc ttggtctttc tctggtcccc tgctctgccc ccaaggaact 206160gcagtccagc agtactgtga attttttgtg ccacacctta aaaggagcag ccgttggtgg 206220ataaataccc cagctccctc accctcaggt gggatgaccc ctagagctcc ccagcaagac 206280caagccccgg ttacctacag tggaaactcg cttgatcaca tactgtttac gttccaccct 206340cttttccctt ttctcacttc tcctctcccc tactggtgct tcctgagatc acctcccaga 206400caaaccactt gcacccgaac ccttgttcca gggtctgcct caggcagggg gaccccaaac 206460gtgtccttgt gctacatttg tgctatccac gtagtagctt gtttaatcat caccatgacc 206520acatgaggaa cacaggtaaa tattaaaatc ctgtcttagt ctgctcaggc agccataaca 206580aaataccaca cactgggtgg cttatacagg aaacatttat tctctcatag ttctggaggc 206640cgggaagtcc aagatcaaag tgttagcagg gttagttagt tcctggtgag ggccctcttc 206700ctagcttgca gatagccacc ttcttgctgt gtcctcatat gtcaaagaga gagagagaga 206760gttgtgatgt ttcttcctgt tctttttttt tttttttttt tgagacaaaa atctcaaaaa 206820aaaatctatt ttttttttag gcaaatcaca tttttttgtc acccagcctg gagtgcagtg 206880gcacaatcat agctcactgc agcctcaaac tcctaggttc aaacgatcct cccacctcag 206940ccccttgagt agctgggact acagatgggc accagctaat ttttttaaat tttttgtaaa 207000gatggggtct tgctatattg cccaggctaa tcttgaactc ctgggctcaa gtgatcctcc 207060caccttggcc tcccaaagtg ctgggattac aggcatgagc catggcatgc ggtctcttcc 207120tgttcttata agggcactaa taccatcatg aagtccccca tgacctcatc taaccctagt 207180tacctcttaa aggccccatc tccaaatacc atcccatcat aggttagggc ttcaactcat 207240gaatttggag gcgggcacaa tttagtccat aacaaatccc cttaatcaca tcaagtaaga 207300cagagttaca ggagggtctg tgactcctcc agggtcccat tttcctagaa gccaggctaa 207360gagccccacg acgcaggaac ggccctttct actcgcaaac aaagagaaaa gccaaggaga 207420agccaacacg gagtctggct ctgcaaaccg ggcaggattg ttaaagacct cctgggctcg 207480gggatggggt gggcggattc cggctccaca gctgcatctc caaggggccc gtggctgaga 207540ggggggttgg ctgtgtgttt cttcctcccc tttcagatcc tgacgggcga agactggaac 207600gaggtcatgt acgacgggat caagtctcag gggggcgtgc agggcggcat ggtgttctcc 207660atctatttca ttgtactgac gctctttggg aactgtatcc ttcatggaga gagagaaggg 207720gacaggcctg gacctctggc agaggagagg ttgcaggggc tcaagggagg gtactgagag 207780acccagatac ccagggccca agtggtgtcc caccagtggt tgcttttcct gactcagaca 207840tttgcagaca ccctcctgaa tgtgttcttg gccatcgctg tggacaatct ggccaacgcc 207900caggagctca ccaaggtgga ggcggtggga gaatgtttct ctggcaaagt taccacctgc 207960ccatggcaga tcaggacggg ggtgggggtg ggggtggggg tgggggtggg ggcatgggaa 208020cagggttaga acttttgccg gggatgcacc atgcaaagag aaggcgcctc tccccccact 208080cccagaaaca gactgtccct catcaagcaa attctacagc caagagggtg ggaaggggga 208140aggcagtgag gtcgctgcag gaaacggatg gcaaactcaa ccaaaaggcc gtttacaggg 208200agtaagcagg gtttccaagg aatggtgtag cccccaggct agtggatggg agagggagtg 208260ctgttatggg gacccagtca gagctggggc caaggaaaaa gggctgccac cagccctggg 208320accttagaga acccagaacc atggcaaggc acagatggag tggccaataa atgtccccac 208380cttctctctt cctctggctt cccgctggag cctcccctta gccaaacgca gcatgttaag 208440agctagcctc cgtccagcct aagcctctcc ccaaggaccc tattaagtta agattacatg 208500taacaggtac agggtcttcc tctcagccct ggggtctccc tcagcattgc agccccacct 208560ccagtgcctc gaggtattca ggacatgttt gtgaaattga accaaaccaa gcagacgttg 208620ccaacgctcc atctgccggc cctggcagga gggagagaga gtttcccggc cccagctccc 208680agtggaggga agcggaagtc tctgccatcc caagcacacg gccacaagcc tggccactgt 208740ggagctggct ggcatggctg agccgagggc tgatccagcc atgagctcat ccaagttcca 208800agagtccatc cttaggggct ggtgcaggag ggtagcagaa ggggagggag aaaggccagt 208860tcgtttatct cctgggaggt gtggacattc ctctccagat ccacattctt tctttcattg 208920atcctacaag catttcttgg tcatttaata cgtgttttta atcctattca gtcctcatgg 208980aaaccttagg agccaagttc tctgagcccc attttacaga tttcatcatt cagtaagcac 209040ttaatgagca cctactgtgt gaccaaggcc ctggtctagg acttagggat taagcagtga 209100acaaaaaaag gcaaaaatcc ctgcctccgt ggagcaggga ttcaagaggg gagacagaca 209160agaaacaaga taaatttgta aacatacgta gcttgtcagt tggtgataaa cacaacagag 209220aaaaattcag tagggaaagt cagggagagt tggaatttta gatgagatgt gtgtcgcaca 209280gagaggttga gagacttgcc caaggccaca cagcagtaag ttgtggagct gggatttgaa 209340cccaggccgt ctgggtctgc agcttgtgct cttaactgct gtgtaccagt tgcttgaatt 209400tgggcatgtt ttatgctcac ttgggaacct gtgggaaatg cagattccag ggcccagcac 209460tggttctata gattatttgg ggagcctgag gatctgcatt ttaggtgttt ctgaggcaga 209520tggtccagag acctagctct gaaaaatgct gggaatggtg ccaggagggg tgggggtggc 209580cctatgagag cagggtggcc agccagatcc catctccatg ttgtctctga cagtgtcctg 209640atctgaccat ttccaaggtg gtaaggttgc tccccgttcc agtgattcgg agcacagcgg 209700gagagctgcc tgcaatggca tgacttttct tatgggcggg ttcatttctg gccatttctt 209760tctcgttgcc ttttctttgc tttttctttg ttggcttttc tgttttacga atgaggccct 209820gcatgaaggc tgaagaagga tttaaagtcc aaaaacgtct ttttctgtat gtatttttaa 209880aacctcttcc cccattctcc tcctctctga acctaaccac cagtgagcag cagcaccctg 209940ggcagttggc tgtagcccaa gtgccctgct ctcctctccc caccgccttc ctgtcatggg 210000ggctgggaat ataaattcct ctcctcattc tccttctggg ggctgttgac agtgcatggc 210060aggggccatc ggatgccagg ctcttctgtg tgtgagggta gttggtgttt tttgaaagtt 210120ggttcagaga gttcacatgg ctcagaaagc ctagtgagag gaaaatcttt gcactgcttt 210180ccagctcatt aagacaggat gcaggggcca ggcatggtgg cacatgcctg gaatcccagc 210240actttgggag gccgaaatgg gaggatcatt tgaggccaga agttcaagac cagcctgggc 210300aacatagtga gaccctgtct ctacaaaaaa aaaaaaaaaa ttaaatgtat acaggcatag 210360tggcatgcac ctgtagtccc agttgcttgg gaggctgagg tgggaggatt gcttgagccc 210420aggagttcaa ggttacagtg agctatgatt gtgccactgc actccaggct gggcaaccaa 210480gggagactct gtctctgaaa acaaacaaaa gaaaaaaaaa taggctgcag gaaagtcttc 210540attgtaggaa gagaagggac atttttattt tttgttatct ggctgtgtgt taaaataggc 210600ttcataatga gttagatgtc aaacttatac acagagggga tagcaataca cttaaccaat 210660agcaggtacc cattccaatt ggggagcctt ggttctgatt ggtcgaaata tttcaaatgt 210720tgcccctggt cagcaacagg gtcagaagtg agtccccaag gcctagttca tgttttgtga 210780acaaagattc cacgtgcctt ttaggacgag caagaggaag

aagaagcagc gaaccagaaa 210840cttgccctac agaaagccaa ggaggtggca gaagtgagtc ctctgtccgc ggccaacatg 210900tctatagctg tgtaagtgcc cctaatccct gggatgctac cctggctcct gaacgtccac 210960actatcccag gcacagattt gggaagcagt gggggtggtc cttgacagaa ctgagcttta 211020ggaagagaca cttcttgtcc ttccacccac tttcactcaa taaatatttg gttagcagct 211080gttatgtacc cagcactgtt ctaacttctg gggatacagc attaacaagg aggaaaaaaa 211140aaatcccacc tgtgtgtagc cattctagca agggaaggag tcaataaatt agataaataa 211200gtaaattata tattgtgtta gaaggcgatg gaactacaga gaaagtaggg gagggaaata 211260gcaaatgctg ggagtgaaga gagttgtgat tttaaacgaa gttgtcaggg aaggcatcac 211320ctagaatagg ggtccccagt cccggggctg tggactggta ccaggccgag gcctattagg 211380aacggggctg cacagcagga ggtgaacagt gagcaagcaa gcattaccgc ctgagctcca 211440cctgccgtca gatcagcagg cagcattaga ttctcatagg aacacaaaca ctattgtgaa 211500cggtgcatct gagggatcta ggttgcgtgc tccttttaag aatcgaatgc ctgatgatct 211560caggtgaaac agtttcatcc caaaaccacc ccccacacct aggtctgtgg aaaaactgtc 211620ttccacaaaa ctggcccctg gtgccaaaaa ggttggggac tgctcaccta gaaggttaca 211680tggcctgaag gaggtgaggg aggagccact ggggggcctg gggaagggca tcccaggcag 211740agggaacagc ataggcaatg gccctgaggc aggaacatgc ctgatgtgaa ggaggcctgt 211800gtgactagaa tcgaatagta agtgtgagga ggtgaaggca aggaggtgac aagcagatta 211860cacagggcct tctgggtcag gggggaggac ttgggctttt gcccctagcc aggtgggagc 211920catggagggt tcttgagcag aggaggctgg gacctgactc agatgctcac agactcctag 211980cattcagtgg ggagtagagg gtggagagca ggagtgggag gctgagatgt gggttggttc 212040gcctgggtca tccatccaag ctacagtgcc tagcaatgct ctaagtcctg tgaccatgcc 212100actgcaggaa agagcaacag aagaatcaaa agccagccaa gtccgtgtgg gagcagcgga 212160ccagtgagat gcgaaagcag aacttgctgg ccagccggga ggccctgtat aacgaaatgg 212220acccggacga gcgctggaag gctgcctaca cgcggcacct gcggccagac atgaagacgc 212280acttggaccg gccgctggtg gtggacccgc aggagaaccg caacaacaac accaacaaga 212340gccgggcggc cgagcccacc gtggaccagc gcctcggcca gcagcgcgcc gaggacttcc 212400tcaggaaaca ggcccgctac cacgatcggg cccgggaccc cagcggctcg gcgggcctgg 212460acgcacggag gccctgggcg ggaagccagg aggccgagct gagccgggag ggaccctacg 212520gccgcgagtc ggaccaccac gcccgggagg gcagcctgga gcaacccggg ttctgggagg 212580gcgaggccga gcgaggcaag gccggggacc cccaccggag gcacgtgcac cggcaggggg 212640gcagcaggga gagccgcagc gggtccccgc gcacgggcgc ggacggggag catcgacgtc 212700atcgcgcgca ccgcaggccc ggggaggagg gtccggagga caaggcggag cggagggcgc 212760ggcaccgcga gggcagccgg ccggcccggg gcggcgaggg cgagggcgag ggccccgacg 212820ggggcgagcg caggagaagg caccggcatg gcgctccagc cacgtacgag ggggacgcgc 212880ggagggagga caaggagcgg aggcatcgga ggaggaagta agtggaggtg acctcgaatc 212940cgcagaatga cggtaacatt aataatgaca acagccaaag tagcacgtgc tgtgtatttg 213000tttataaaaa tatattataa aatgctgtat ttggccaggc gcagtggctc acgcctgtaa 213060tcccagcact ttgggaggcc gaggcggatg gatcacgagg tcaggagttc aagaccagcc 213120tggccaagat ggtgaaaccc cacctctaat aaaaatacaa aaattagccg ggcacggtgg 213180caggcgcctg tagccccagc tactcaggag gctgaggcag gagaatcgcc tgaaaacagg 213240gggcggaggt tgcaatgagc cgagatcaca ccaccgcact ccagcctggg cgacagagtg 213300agactctgtc tcaaaaaaaa aaaaaaagtg ctgtatttgg ccaggagcag tggctcatgc 213360ctgtaatccc agcactttga gaggccgagg cgggcggatc acttgaggtc aggagttgga 213420gaacaggctg gccaacatag tgaaaccccg tctctactaa aaatacaaaa attagtggtg 213480gtgcccacct gtattcccac tactcaggag gctgaggcgg gagaatcagt tgaacctggg 213540aggtggaggt aggttgcagt gagctgagat cgtgccatca cactccagcc tgggcaacag 213600agcaagactc tgtctcaaaa aaaaaaaaat gctgtatgtt tttgtttttt tgacacaggg 213660tctcgcctgt tgcccaggct ggagtgcagt ggcagtcata gctcagtgca gcctctacct 213720cccgggctca agccatccgc ctcagcctca caagtagctg ggaccacaga catgtgccac 213780atgcctggct aatttttgta gagacagtgt tttgtagaga cagggtttca ctgtgtttcc 213840caggctggtc tcaaactcct gaactcaagc attccgcctg ccttagcctc cctaaagtgc 213900tgggactaca gggttgagcc accacactca gcctaatttt tttaccttta gtagaaatga 213960ggcctggctc tgttgcccag gctggtcccc aactcctggc ctcaagcaat catcccacct 214020cagtctccca aagtgttcgg attagaggct tcacagatgg ggaaactgag agattgagtg 214080agctcctcaa ggtcattcct ctaaccagtg tccttgaacc caggctctct ggcaccagag 214140gccttgagca tttcagggaa actattaaga gaagccccac tgtcgtccag aattatatag 214200tcttctgtgt tcttgctgtg tgacttttgc aaagtgactt catatctctg ggcctcacac 214260aatggaaata gtgggatcta attgggtcat tgccaggatt gaatgaggta atgtatgcaa 214320agggcctgga agagcagctg acacataata agtgctcggt aaatttagag catttttggc 214380cattttcagc caactctatt tacctaatgc tattctttgg aagtttgaaa agccactctg 214440ttgggaggcc aaggtgggag gatcacttga taccaggagt tggagaccag tctgggcaat 214500agaggcagac cccatctcta taaaatataa aaaattaaac agatgtggtg gcatgcacct 214560gcagtcccaa ctacttggga ggctgaggca ggagggtcac tggagcccag gatgtctagg 214620ctatgatgag ctatgattgc accactgcac ttcagcctgg gcgacagagc aaggctttgt 214680ctcaaaaaat aaaataaaaa ataaagaaaa agaaaaggca ctttgggccg ttagaattga 214740agggagagca gagtttcaaa gctttggatg cagcgggatg tggtggctca tgcctgtagt 214800cccagcactt tgggaggcca aggtgggagg atccacttga gccccggagt tcaagaccag 214860cctgcgcaac atagtgagac ctcacctttt aaaaataaat aaaaatgtta gaaagctttt 214920gaggcatctt ccaggccagc aacttatcca ttcagaacca gcatcctctt tttcataacg 214980acattttgta atactttcta gcagatgcta tagtgattct gcatataggg actcaacaac 215040ttacccatta aaatagacat cgtagacatt gtcctattac aaattaacct gctcttagtc 215100ctcttttata ttaccatcag ggcataatat tgattttttt aatgatgggt ttaagtgatc 215160ctgttgtatg acatatgagg taggccagca cttctcaaaa tctaatgtgt atgtgaatcc 215220ccagggatct tgttaaaaca caaattgtaa ttccgtaggg ctaaggactc agtggagcct 215280gagattctgc atttgcaacg agctcccaga tgaggctgat actactggtc cagggaccac 215340attttgagta atgagactct ggaggacata gtgaagtaat tctgatatgt acaccataca 215400caaaatcacc atgaagtgac aggcacaaat gatggctaac tctgggttgt gtggacaatt 215460caaaccacat gaggggagtt gccagcagtg tcaagatgtt ccacaatgtt gaacacctct 215520tggcaaagtt ccatatacaa aagagtctag tctttcttcc atttatttaa tagttgcatt 215580gcaggaaaat gcaatgtata ttaaaaacat acaaaaaata tgttgtgttc ttatgtaaaa 215640gagttaggtt taaactaaaa gcacaggatc aggtgcagtg gctcccacct gtaatcccag 215700tgcattggga ggctgaggaa ggagaatcgc ttgaggccag gagttcgaga ccaacctggg 215760cgacataagg agacctcgat ctctacaaaa gaagtttttt aattagccag gtgtggcggc 215820aggtgcctgt agttctagct acttggaagg ctgaagcagg aggattgctt gagcccagga 215880gttcaagatt acagtgagct atgattatgc cattgcattc caacctgggc aacagaacaa 215940gtccttgtct caaaaaaaaa aaaaagaaag aaagaaagaa aaaacccaaa caaacaagca 216000aactaaaagc acaggtaatt acaagcaaga tttttcacct ctttgaggga cattagaaag 216060tcatgaagag gaaaagataa gtctttccca tatgggactg tcatgtacat ggtagggtat 216120ttagtataac tgcctaccat tctctaagtg cctgcagtgc ccctcaatca ttatgttatt 216180aggtttccac gtagttctac aacagttttc tgaaaaccat tgttctaggt cattctttcg 216240cttcaatctt ctcctatggg tttatgcatt cattcagtta gtatttacta agtgcctact 216300atattctaag ctcatgctgt gagttcagtc acacaactgc aagtgaagtg gtctgagaca 216360ttctgagaaa tacgaccaag aaactgctcc cagggtctca gggcaggttt ccagaggagc 216420aatctgagaa gggagtagag tgtttcagtc taacaacagc atgtgcaaag gccctggggt 216480ggaccagaag gaggccagtt tgcaggacat gactagtgac gagaaagtga caaagaaatt 216540gaaggtgcat tgatgagact ctggggctgt cagtcactca ggggaatgag agatcaaaac 216600gggagtttag gtggaataaa gtgtttacca cagcactctc tgtatagtaa agaccaatga 216660agagccaggt acaggccagt gtgatggttc acgcctgtaa tcccagcact ttgggaggca 216720gagacaggtg gatcacctga ggtcaggggt tcagaaccag cttggccaac atggcaaaac 216780cctgtctcta ctaaaaatac aaaaaattag ccaggcgtgg tggtggacgc ctataatccc 216840agctactcag gaggctgagg cacaagaatt gtcctgcgag gcagaggtta cagtgagctg 216900agatcacacc actgcactcc agcctgggca acagaacaag actctgtctc aaaaaaaaaa 216960aaaaaaaaaa aaagccaggt acagtggtat gcacctgtaa tcccagctac tcaggaggct 217020gaggcaaagg attgcttgag cccaggagtt cgagaccagc ctgagcattt agagaatggg 217080aggccagtat actaaatacc ctaccatgta caagacagtc tcatatggaa aagaattatc 217140ctttcctctt catgactttc tagtgctcct cacacaggtg aaaaatcttg cttataatta 217200tctgtgcctt tagtttgttg gtttatttag ggttttgttt gttttttttt tttttttgag 217260gcagggtctt gctctgttgc ccaggttgga ttgcagtagc attgctcatt ttagagatga 217320gcaagacctc atgtctaaaa aaaaaagaaa gaccaatgat tattaattac tcttgctatt 217380attactaata ttactgttat tatcagcctt attaacagat ctactgttat tgaaggaggc 217440agagtgacag ggacaaaatg tctctcccta acaatatgcc aggaagagtt tttgaaagac 217500aacagtaaac attggaaact acaagagcag caaagcctgg ttgtgaaagg caaggacttt 217560ggggcaggca gtcacattcc tgccctatca cttccaggct gtgtgacttt cagaatttca 217620ctcctctctg ggcctccatt tcctcatcta taaaatgaag ataagaatag tagctacctc 217680cttctctggg tataagattt aactgagccg ggcgcggtgg ctcatgcctg taatcccagc 217740actttgggag gccgaggtga gcggatcaca aggtcatgag ttcaagacca tcctggctaa 217800tatggtgaaa ccccatctct actaaaaata ccaaaaaaaa aaaaaattag ccgggcgtag 217860gtggtgcacg cctgtagtcc cagctactcg ggaggctgag gtaggagaat ggtgtaaaac 217920ccgggaggcg gagcttgcag tgagccgaga tcgcaccact gcactccagc cggggagaca 217980gagcgagact ccatctcaaa aaaaaaaaaa aaaaaaaaaa agatttaact gagttagtac 218040gtgtaaaatg ctttgagtgg ttcctggctt ataccaagag ctcaataaat gttagcaatt 218100ttttgtagca ttttggggtc tcactatgtt gcccaggctg gtgtcaaact cctggcctca 218160agaaattctc ccactttggc ctcccaaagt gctggattta cagacatgag acaccatgcc 218220tggccatgtt agctattatt aatatgaata ttattaagta ctcaatgaat gctattttta 218280gcagtaatag taagcactca ggaagtgtca gctaatactg ttagtaatac tctcatcaat 218340aaacataaaa agcaataagg acccagcttg cccaaatccc acagatggtt cctgctccct 218400ctcttcttca gaggaagaaa ctatctcccc actttcaccc ccatagcctc agctggccag 218460acccccattc tgaaccaggg gagtactgct aattccatta ttaatagaca catcaaacaa 218520tctggccggg agagacatta ttcatttggc tgataaagag gttctaaggc tctttggaaa 218580taaaagttca tgaagattca tgcactttaa gagaaaaaaa ttcaagatca gtcattcatc 218640tgctttaaaa aaagtggcaa agataaaact ttatttgaga atataaaata ataaaaagac 218700attttcgttc tctgttgtga caaagccagt ggccttcgga ggtctgcctt gtacattttt 218760cctcttcttc agtcattcct tgaggctttt tgcaaacgta ccctgtgttt ttcattctcc 218820agcatattga taattttttt tttttgagac atggtctcgc tttgtcatcc aggccccgga 218880gtacagtggt acaatcatgg ctcactgcag ccttgacttc ctgagctcag gtgattctcc 218940cacctcagcc tcccgagcag ctgggactac aggtgtgcat gaccatgcct agctaatctt 219000ttgtattttt tgtagacaca gggttttgcc acattgccaa ggctggtctc caactcctgg 219060gttcaagcga tcctcccacc tcagcctccc aaagtgctgg gattacagga gcgagctacc 219120ttgccaggcc gatcatattt ttttcctttt tattcacttt gtcttctcct cattcctacc 219180ttcatctgtc tttcagtggc tcactccagt gaaaagtgga ctgacgcaca ttctatttca 219240tataattcaa tggctgctgg ccccagatcc cccataccag gtggccgagc ccagtggccc 219300tgcagggtgg acaaaatgag ggtggaactt tcccagactg tcagtaaaaa tctatggagg 219360acagagcttc tgcctctccc ttgcaaccag gcagtgcctt ctcccaggcc tatctgcttg 219420caaagggaac ttttgccaag acctgctcca ctctagaatt cttatctctg ctgttcgcat 219480cctaattcca cctgcatctg tcaccatgac aacctgctcc ccaaaaggaa caggaagaga 219540gatgctggac ttttgagctc cacagtttat cctgcatggg ggtagggagt ggttaattac 219600ttagcactct aattcttacg gtacccccaa tgggcccaag ttggtttttt taaaaaaaaa 219660cagtcttgct ctgttaccca ggctggagtg cagtggcaca atcatagctc actgtagcct 219720caaactcctg gactcaaatg atcttcccac ctcagcctcc caagtaactg gaacaacagt 219780ctcgtgcaac tacgcccagc taattttttt tttttttttt tttttttaga gatggggtct 219840cactatgttc cccagactga tctcaaactc ctgggctcaa gcgatcttcc ttcctcagcc 219900tcccaaagtg ctaggattac aggcgtaagc cactgtacca agctgcccca ttaaagcttt 219960gaacaccaga gagcccagct cagctgtttt ccagctgggt aactctgggt aactttgcct 220020ctctgaacct cagtctcctc ctgtgtgaaa tggggctgat cactataccc atctcggatg 220080gtggtagttg cagggattaa atgagttaat acgtgaggtc cttaggacag ggggtgggga 220140cacgagataa gcaataaaca ggaactgctg ttattatcac ccccacataa tccgatctca 220200gggtctgagt gtgccccagg caaggtgtcc acagccctct gcagaaggat gcccaagtga 220260tcagctggca caagaacgcc acgcacagca ggtgttatgc aactggccac ctattccagg 220320cagaggatgc cagatcccca gggagaaggg ggtaggggtg cagcttcaaa gttttctgcc 220380ccttttgagt tctccttgga gacactttgg aaatgaaacc tcccggaaat tgatattagg 220440cctctgcagg ctgagcttgt taaaatttcc caacaaacag agccaacaga cgctctacaa 220500ggaagcaaaa acaagacaaa acacattggc agaccctttt ccatctgctc ttggtagatg 220560gtattcctct aagaaaatgc cgccacgagt ttctccatgg cttcttgagc tggtggccaa 220620aggatttagg ttctctttga aattataact taactgggcc tgctttatgg cagggatatc 220680actctctgaa atgtgtatat atatgtgtat gtatatatat acacatatat acacatatac 220740atacacaggg ccaggcgtgg tggctcacac ctgtaatccc agcactttgg gcggccaagg 220800caggtggatc tcttgagccc caggagttca ataccagcct gaacaacata gtgagaccct 220860gtctctacaa aaattaataa aaataaccag gcatggcagt gtgtgcctgc aatcccagct 220920acccagggtg ggaagatcgc ttgagcccag gagttaaaag ttgcagtgag ctatggtcat 220980accactgcac ttcagcctgg gcaacagagc aagaccctgt ctcttaaaaa tatattatta 221040ttattataca cacacagaca cacacagaca cacacacaca ttacagatga tgagaaaata 221100ctctcagcca ggttttcatg atacacaact tctcaaaaag catcacaagc aggttagaat 221160tagggatttc tttgtggact gtccaagatg ttgaggaaat attggtttag aatttacctc 221220atttaggcca gaaatggtgg ctcacgcctg taatcctaac actttgggag gccaaggcca 221280atggatctct tgaagccagg agttttagcc tggccaacat ggcaaaatcc tgtctctact 221340aaaactacag aaaaaaaaaa aaaaattagc cgggtgtggt ggcacaggcc tgtagtccca 221400gctactctgg aggctgaggc aggagaatca cttgaacctg ggaggcagag gttgcagtga 221460gccgagatcg tgcattacac ttcagcctgg gtgacagagc aagactccat ctcaaaaaat 221520aagatagata agataaatat atataatata tatgttatat atataatata gaaactacag 221580aacaagtgat ctttgtatgt ttccagaata taacagcggg acaggcatag gatagacgtt 221640cccattgcaa aagggagaaa ttggaaggga taaagaggtc accagtccta agcaagtgct 221700aaatccagca agacaaatcc cattaggttt caaggcctga gaataatcct cggtgactct 221760cagctcatta acatacttag ttctcagagc cagactcaat gaggttacgg cccgcatgtt 221820atgggtcagg aactgaggct aagtaactca ctggagatta tgtggtaaag aaggtccagg 221880atcattgctt cagtctccag gatatgggga aggttctact cctgttatcc caaattttaa 221940aatgtgggaa ctaaggctca gagaggttaa gcaaatcaca cagggttgca cagctagtga 222000tgttgctgag atttccctgt gtgtagtggc tcatgcctat aatcccagca ttttgggagg 222060ctgaggcaag agggtcgctt gatcccagga gtttgagacc agcctgggca atatagtgag 222120acctcatctc tacaaaaaga aaaattaaaa agttagccag gcgtggtggc aggcacctga 222180agtcccagct actgggaagg ctgaggtggg aggattgcct gagcctggga ggtggcgatt 222240acagtgagct gagatcgcgc cactgcacta caacctgggc gacagagtga gaccctgtct 222300caaaaaaaaa aaaaaaaaaa gacattgccg agattcaaac ccaggtcagc ctgtcttctg 222360aaatgtccct ctatgaccca ctcacaaaac tgagaaggca gaaagttgct tggacctgtc 222420tatttcccct gtgcagtctc agagaaacag tggaactgcc tcggtttctc cttccgggaa 222480gtattcatag aagcatccca cttacctact ttggtctgaa aataaattag cttgtctctc 222540ttccacttac taaaaacacc gtgggttttt gcaagttaaa atgcaaaaat aaaatgagga 222600gaatggtgct ggtagtttag ccagtgggaa gccctctggg gaaagccagc cttttattta 222660ttacttattt atttatttat tctttctaga tagatttatg ggaaaccagg gctgtgttgt 222720ccaggggtct gtagtccaga aggcatcaga tgggctacta agtgagtctt tgtccacctg 222780tagatggcaa gaggcagggc ccaggtgtcc atggcttgga gaggcagggg ttgatgggag 222840gtttgaggct gtgggatctc tcctggggcc tcagtatcct catctggata atggggacat 222900tctggccagg cacggtggct ctatatatcc agcacttagg gaggcctata atcccagcac 222960tttgggaggc tgaggtgggt ggatcactgt aggccacgag ttcaagcagc ctgggcaaca 223020tggcgaagcc ctgtctctac tgaaaataga aaaactagct gggtattgtg gtgcacgctg 223080gtaatcccag ctattcggga ggctgaggca cgaggatcac ttgaatccac gaggcagagg 223140ttgcagtgag ccaagatcct gccactgcac tccagcctgg gcaacagagt gaggctctgt 223200ctcagttaaa aaaaaaaaga aaaaagaaaa agaaagaaag aaaaagaaaa tgggggtatt 223260catttatcat ttgacagtaa gtttacccag cattgactgt gtgagaggcc ctgtactagg 223320cagtgaaaac tcagctaaga ataagaaagt taaaaacaag ctgggcattg tggtttacgc 223380ctgtaatccc aacattttag gaggccgagg aggaagaatc acttgaggcc aggagtttga 223440gaccaccctg ggcaacatag tgagacgcca gtctctacaa aaaattgtaa aattagccag 223500acatggtggc gtgagcctgt agcctcagct acctggaggc tgagatggga ggatcactgg 223560agcccagaag ttcaaggctg cagtaagcta tgatcctgcc actgctctcc agcctgggca 223620acagagtaag accctgtctg aaaaaaaaaa aaaaaaagag gccaggtgca gtggctcaca 223680cctgtaatct cagcactttg ggaggctgag gtgggtggat cacttgaggt caggaattcg 223740agaccagcct ggccaaaatg gtgaaacccc atctctactg aaatacaaaa aattagccgg 223800tcgtagtggt gggcacctgt aatcccagct actcaggagg ctgaggcaag agaatcgctt 223860gaacctggga gccagaggtt gcagtgagcc gagatcacgc cactgtacga cagagcaaga 223920aaaaagaaag aaagaaagaa aagaaataag atgatgggga gttgtggaaa cctgtccatg 223980ggcacgtgaa ggtcttgacc tctgaccaag aagtgaacag gctcctctca attccaggca 224040ctgcagggat ctgggacatg acttctccat gaccaaactg taccctttcc ttttcttttt 224100tgtttttttg gtgacagggt ctcactctgt cacccagact ggagtgcagt ggggcgatca 224160cggctcactg cagcctcaac ctcccaggct caagcaatcc tcccacttcg gcctcccaag 224220tagctagaac tacaggcaca cagcgccacg cccgtcaatt tacacatttt ttgtagaaat 224280agggtctcac tatgttgccc aagctggtct tgaactcctg gccttaagca atcctcctgc 224340ctccgcttcc caaagtgctg ggattacagg cgtgagccac tgcgcccagc ccaaattgta 224400ctcttgaaag atggaatctt agctaggatc ctgaactgtt gccttttatc ctaaatcagt 224460tgttggttct ttttcattca cttgccttcc tcagagagaa ccagggctcc ggggtccctg 224520tgtcgggccc caacctgtca accacccggc caatccagca ggacctgggc cgccaagacc 224580cacccctggc agaggatatt gacaacatga agaacaacaa gctggccacc gcggagtcgg 224640ccgctcccca cggcagcctt ggccacgccg gcctgcccca gagcccagcc aagatgggaa 224700acagcaccga ccccggcccc atgctggcca tccctgccat ggccaccaac ccccagaacg 224760ccgccagccg ccggacgccc aacaacccgg ggaacccatc caatcccggc ccccccaaga 224820cccccgagaa tagccttatc gtcaccaacc ccagcggcac ccagaccaat tcagctaaga 224880ctgccaggaa acccgaccac accacagtgg acatcccccc agcctgccca ccccccctca 224940accacaccgt cgtacaaggt gagaccctct gctctcacat cactgggcag gggacctggc 225000gtccctggag ccagaggctc tgctgagtga ccctggactg tgaccccatc tctctggcct 225060cagtctcctc ccctggaaaa tgggcatagg cgtagtttcc taccccacag ggctgtggag 225120ggttcagtga gataatttgt gcacagtgcc tggcacgggg ttgtgttcag tcgggttagc 225180aatatcttct acgtccttcc ttcccaaggg gagccaggaa gccaccccat ttgaggagca 225240atagggtcct ctgatggaag cttgaggggg tcagatgatt gattctctcg gcccagcact 225300gtccaaaaga aatgtaacac aggccacatg caaatgtcag tttaaactct ctagtcgcca 225360cattaaaaaa ggggccagat gtactggctc atgcctgtaa tcccagtact tcaggaggcc 225420gaggtagagt gagccaagat ggcacctctg tactgcagcc tgggtgacaa agcgagactg 225480tctcaaaaaa aaaaaaaaaa aaaaaaaatg gtgaactgct gggtggatta tgtcttaagt 225540tcatctagtg tcagttctat gtgagagatt ttcatgagtt tgctggataa aggctttcca 225600tggtcctgag acctaagatc ctaaggtctt gtcactgtgc ccattttata gatgtaggga 225660ctgaggctca gagaggctca gcctgcccgt gggcacataa gcaggctggg ctgcagaatg 225720gaagctccag aggctgatgg ctcctccccc tgagtcaaga gaggggtgct aatgggggca 225780tgccatgcag tttatgggag gtctcagtat ttctatctgt tcagtgggtc tcttggcact 225840ctccctacct gcctgcaagt gagggtgtga aggtccaacg

aggatagggg caggtctgtg 225900ttaatatccc atgagggccc caccgcactc aaggctatag agtggttgag agcaggctct 225960cgggggccag gccgcctggg ttccaaatgc cagctctgcc acttcctgct gtgtgacctt 226020agacaagtca ctttacttct ctgtgcctca atttcctcat ctgtaaacag gagatcagaa 226080tatatcaacc tcagggctat acaagggttc agtgatgtca taagatgcct ggtatataca 226140gcaggcactt tagaaatgtc agccgcttct tgcctgccct gggagtacac aggagttccc 226200agagacttgt gggaaattgt ggagggagcc ctgtgttggt tcttgtccca acagtgaaca 226260aaaacgccaa cccagaccca ctgccaaaaa aagaggaaga gaagaaggag gaggaggaag 226320acgaccgtgg ggaagacggc cctaagccaa tgcctcccta tagctccatg ttcatcctgt 226380ccacgaccaa cccgtgagta tggcccccag caagggcagg gggggcctgg ggctcccacc 226440agggtggcgg aagtcaggcc agatagaggg caatgagtga gtgttgacca ccatgagtcc 226500agggatacct ttgaacaagt tgaaaatgga tgctccttcc gtaagtcagg taagatgatt 226560tgtcacaata tactttgttg gaagagaccc ctgtcctgcc atccactaga aaatcattgt 226620tatttatgac aataaataaa caaatttgtc ataaataaac aaataaattt gtcctaaaca 226680acaaataaat ttgtcataaa taaacaaatc ttcactgtga tgtaagaggc acccccttag 226740aaatggctgc cttgtgcagt acacagcctg aacaactgca cgtggcagcc ctaggacctg 226800aactctgttt ctaacctaga ctctgtaagg gtttagattc tgggcggata gtgtctgagt 226860tccatggcct tctgtcttgg gcatctttga aatggataga ctatttaggg gagaaattta 226920tcccatgaat gtcgtagtgg ctcggaggtt gttttagaat tgaatgtctc ccagggatat 226980ttcttgaaag cctgaccgct caaaatgctt cttgacaatg aaggatcatg tcagataaga 227040tgggggagaa gctgctttct ataatctgcc tcttggcaac tcaccctggg tagtaataaa 227100taaaagtacc tttaaagtac ttttttattt agttgactta tcgattttac taaggaaaca 227160cttatgtggt atctactcag tgccaggcac tgttctgagt gccttaaaat tttttttaat 227220ttctctgagg ttgttactat gcttagctcc atttgacaga tgaaaaaact gaggtccaga 227280gacgtgaatt cacctgccca aggtcacaca gcaagccagt gggagagctg gagtttgagc 227340ccagacactg gctctagcct ccttgttctt aaccactcag ctctgctgcc attcacacaa 227400ccttatgaac tatttattat tggctccact tattaagagg ttaactggca catcccattg 227460gcacattcaa ggctctgata aggcctgcaa ttcataattt caataactaa ctttttggag 227520cccctatcat gagccaggca taaattaagt cttgggtctc atgattttgt gaagtaagca 227580ctagtattac ggctatttta cagatgaggg caccaaggca cagaggggac aagtaacttg 227640cccaaggtca cacagctaat ttttaaaaag aaagaaagaa atctacttaa cccatagatt 227700cacaatattg tttggccctg ggacatttaa tatcgaaaag cctttttatc tcctacagaa 227760ttaaggaccg tatttcttca acctagcttg gggatcaaga tacttcaaga gggtcgtttg 227820ggagtgatag gaactttgct aaacagggca tgtgaatgtc ttctctcacc gaggtcccct 227880ctgccttctt ggggttccag gacccagaga gggcccccac ctggaggagt ttaatagttt 227940gttgtgtagg aggccttggg ggttggagat ctcagtagtg gtaggtaaca tgagattatg 228000gaagaaaagg gtttgtgagc ctgtggtctg agtggacctc tgcacgccca tctgtctcca 228060acagccttcg ccgcctgtgc cattacatcc tgaacctgcg ctactttgag atgtgcatcc 228120tcatggtcat tgccatgagc agcatcgccc tggccgccga ggaccctgtg cagcccaacg 228180cacctcggaa caacgtgagt cccacagagc acaccccttc ctagcctggc tgctctgcct 228240caggccactt tctcctgcat ccaaaatgct cataggtagg gtgggatgtt ggggtcaccc 228300ctaggcatag cccttatggc tgctggttga gaggggaagc tctgattcct tggggatgct 228360cttgggagca agacattcct tgaggcagtt tctctgtgag cctggtgggg tggaggtggc 228420ccagagtgac tggggctgaa aattgctgga ttctctaatg gaggcgtgag actagcagga 228480tatggatgtt gcacattctc tacatggaat aggggggtta ctggggcagg ggcggtgctc 228540agaggtggtc ccctccgcag tagacatttc cctttgtaca cgaagctttg aaagaaacaa 228600ctatttggct cagaaacaca gcctaagctt ttggttttta tgaaagcaag cccctttgcg 228660gatggtgggt ctgttgacaa cccctgttaa ttgagcactt gctgtgtccc aggaagaaac 228720tcagcatgca gtatctcatt taatcctcac aatgcgcccc cccaaccccc cgcccaggca 228780tccccatttg acagatggga aaactgaggc tcaggggaat gagagagtgg taagtggcct 228840gtccagggtc acacagcaga attccaactc tgcatccccc aaagctccca ctgcttcccc 228900caactgtctg catttactaa tcacctactg tatgctacgg atgggtgtgc atagcccctt 228960tgagtcctga caagcaggaa tgagtgcatg cttgtggttg agatggggaa accgaggcac 229020caacaggcaa gggcgtgcct cagtcatggg ctgcgggcag aggcttgacc ccagggcctg 229080gtagagggtg gactggtggc tcctgtttcc ctccccagct ccctccccca acccttccct 229140cccaacccag agccaaaaaa gtgtgttttc tgctggtcca aggctctgct gccctggcta 229200agtaggttag gacccaggca aagctggcga gccccatccc tcaagcccgc ccacagctta 229260ccatgcactt tcccttcctt cccaggcctg gcaggccccc ctggggacct gatgggggag 229320atggaaggaa ataattagaa cgcagctcct ggaggaagct agagccagtg ctcagcctcc 229380tcacagtccg cttagttgct tcccgcagcc tggtttcccc caggggcctc caggagccag 229440gcgtggggag gaggtgtccc tggaggggtc cacaaacccc ctgctgacgc gaggatgctg 229500aagaaggcgt tgccttcggc agggagggca caggcatgga tgatccaggg ggcacggcag 229560ctcccagggc tgaagggaat ctaggcagtg ctcagaccag gccccaggga ctgtttgcaa 229620agagcgttca gctccccggc cccctccctc gtccatctcg cagtcgaaac ttctctacaa 229680gaacactgtg gccccataac gttcacacca cgtaaccacc atccagggca agaaatagaa 229740caaaaacgcc ccacgcggca tgtgcctcct cgatccccca cccccaccgc cttctttccc 229800tctagagctg ctggggacac tgtctggaga catttttggt tgtcacgaca ggagggggga 229860ggtgctcctg gcatctggtg ggtggaggcc agggatgttg ctcagcaccc gccgatgccc 229920aggacagccc ccactctaga ggatgatcca gacccaaatg tccacagagc ccagcttgag 229980aaaccctgcc ttaccggtaa ccacgacccc agcttctgga atgagcgttt ttggcttctc 230040tctttttccc acctgcacag gctttttttt tttttttttt taagagacaa tgtctctctc 230100tgtcgcccag gttggggtgc agtaacgtga tcatggctca ctgcagcctc aacgtcccgg 230160gctcaagtga tcctcccacc tcagcccccc aggtagctag gaccacaggc atgcaccacc 230220acacccagct aatttttaaa tgcttgtaga aacgggcctc gctatgttgc caggctggtc 230280tcgaactctt gacctcaagc aatcctccct cctcagattc ccagagctct ggaattacag 230340gcatgtaatt ccaattctta catgcctgta attggccaac actggccaat tcttaaaaac 230400tgaatttatg tttgctcttc tgtaacattc aataaatgag acacttctat gcttcgcatt 230460aaatgagtac atgttgcttt tgcaggattg atgggcattc tttttttttt tttttttttt 230520gagatggagt cttgctctgt cacccaggct ggagtgcagt ggtgcaatct tggctcactg 230580caacctccgc ctcccgggtt taagcgattc tcctgcctca gcctccagag tagctgggac 230640tacaggcagg cgccaccaca cccggctaat ttttgtattt ttagtagaga cggggtttca 230700cactatcagc cagactggtc tcaaactcct gacctcaagt gatccgcccg ccttggcctc 230760ccaaagtgct gggattacag gcgtgagcca ccacgcccgg tcaatgagca ttctttatga 230820tgctgttttg agatttactg tgtggcatgg gatgtgttat ccatcccctg ttgacagatg 230880tttgggttgt ttctaagtgt gaatactgtc cccatgccac gcccctcaac atgtttcctg 230940agtcacctgg acagtaattt ctccaggagg ccagatgcag tggctcacgc ctataatccc 231000agcacttcga gaggccaagg tgggagcaat gcttgaggcc aggagttcaa gaccagcttg 231060ggcaacatag tgagaccccc acctctacca aaaaaaaaaa aaattttttt ttttttaatt 231120aaccgagcgt ggtggtgcac acctgtggtc ccagccactt gggaggctga ggtgggagga 231180tcacttgggt ctggaaggtc aaggctgtag tgatccatgt tcataccact gcactccaac 231240ctgggtgaca gagcgagacc ctgtctcaat aaataagaat tcctccaggg tataaaccaa 231300aagcgaagtt tctagagcat ataatttgca agtggttggc ctcagtaaat gcagcttgaa 231360tgtttattgg acaataaaca cagtgaccct ttgggaggcc aaggcgggtg gatcacctga 231420ggtcaggagt ttgagaccag cctggccaac atggtgaaac cccgtctcta ccaaaaatac 231480aaaaattatc tgggcgtggt aacacacaac tgtaatccca gctactcggg aggctgaagc 231540acaagaatca cttgaaccca ggaggtggag gttgcagtga gccaagatgg cgtcactgca 231600ctctagcctt ggcgacagag cgagaccctg tctccaaaat atatataaat aaataaaaat 231660aaacacagtg ggccgggcac agtgggccgg gctcgcacct gtaatcccag cactttggga 231720ggccaaggtg ggtagatcac gtgaggtcag gagttcgaga ccagactggc caatatggta 231780aaacctggtc tctactaaaa atacaaaaat tagccgggcg tggtagcatg cgcctgtaat 231840cccagacact tggaggctga ggcagaagaa ttgcttgaac ccgggaggca gaggttccag 231900tgagccaaga ttgtgccact gcactccagc ctgggtgaca gagtgagaca ccatctcaaa 231960aaaaaattaa aaaataaatg aacgcagtgg cccttgcacc agtagctcat gggaactcct 232020gttcttccac atccttgtca acacttggta ctgtcgactg tttcatttgg ccgatctgct 232080gggtgtggag tgagatctta ttggggttgt gcttggcatt tccctgtaat gaatgagatc 232140aagcactttt ttggattaga ctgagccaca ggaaataaca ttttcaaata gatgaaaaag 232200atctaagtat taggaatact tgaacctaat ttattggtct tttgatttcc tcttgcacag 232260cttattaaga gctccagaat tagattcacc tgacccccac ggcctgccct ttcccagctc 232320cctctcttcc ttctttcctt ccattcattc ctttagtaag tatttgataa gcaactacta 232380tgtgccaggt actgagcgag ccagggagga ttgacagggt atgagatggt ccctgcactc 232440ccagagccca caaaccacca ggcctttgac caggctgtgc ccactgcctc gtgcacctga 232500aatactctcc caccaccatc ccctctgccc acccaggtct ttcaagccaa tccccttgca 232560ccagcccctc cctccaggaa gtcacctcac cctgacccca ggcactctgg tctctgattc 232620ctcttcaagc accacatata acaggaatat aagttataac cacacagatc acagagccca 232680gctcctccag gacccagtac agccccaact gttgatgcat tcattcaaca aacatttctt 232740gagcacctac tgtattcctg accctgtatt ataagctgga gacgccatgg tgacagacag 232800acatccctgt ccttgtgggg ctgacatttg ggtgggggag atggacaatg agattatcag 232860taactacaac aaatgttcag ggagtgataa gtggccgggg gtgtggtggg cagagggaag 232920gagagacttc gtaaagagga tctcaagcac caggagatgg aatttaaaca gccggtcagg 232980ggagtcctca ctgggaaagt gttatttgag ctaagtcata aaggaggaga aagacggaat 233040caaatgggat gtgggggaaa gcattccaga gagacagaac agcctgtgca aaggccctga 233100ggtggaagca tcttggggaa caaaaggaag tgagcaaggg agagaatgag aggaagtgag 233160ggcagggagc tgaatggtca gatcgtgcag gggcttgagg gcctcgggga ggactttgac 233220ttttatccct gaatgaggtg ggagccacgg aggattgtaa gcaggggaag gatgtgcctg 233280acttctttgg tgttcacagc gccctctggt ggccatgttc agtaatgctc agcccttgca 233340gcttctgggt ggatctgatt tttttttttt tttttttttt agacagtctc tgtctcccag 233400gctggagtgc agtggcacga tctcggctca ctgcaacctc cgcctcccac gttcaagtga 233460ctgtcacgcc ttggcctccc aagtagctgg aattacaggc acacgccacc atgcccagct 233520aattttttat atttttagta gacacggggt tttgccattt ggttaggctg gtctcgaact 233580cctgacctca agtgatctgc ctgcctcagc ctcccaaagt gctgggatta caggctcgag 233640ccaccgtgcc cagccggtgt ccaccccatg tctagcacca gccagacact gtgccggcgc 233700accctcatct tcaggcctgg gtgacaccag aggtgtgcta tggtgtgtcc tggacagggg 233760ctgggccaga ggacattgct cgtccaggca gaaacatcag gcctggggag gggcacagga 233820aaaatcaacc taccctggca ggggcctggc cttgaagcag gaagagatgc cgtggcagga 233880agttggcccc agtgtttaaa aaaaccacgt agcaactatt tctcgcccag gatgcccagg 233940aaagcaaggg tactggggga ttagatccat caccaagaag gatacagtca gccctgaact 234000tctctggggc cgcttctaat ccactacagg gcttggggca aattttaaaa ggtacccttc 234060ccgtgggtta gcgaactggc ctagtacagt gatttttttg ttaggatttg ctgccatctg 234120ctggacaatt tcattcacaa catacaaatc tgcagtatga aaagagatgg gaggggccct 234180tgtgcagtgc acgccctgcg caactgtata tagcagctgt gtttcctctt ctgggtagaa 234240actctgctcc ccagtaggcg atcgttagtt ttaccggggc tctgctggaa caggccagtg 234300atccactgct ctcttgcttt tatcccttac aggtgctgcg atactttgac tacgttttta 234360caggcgtctt tacctttgag atggtgatca aggtgagtgc agattataag tgagaacaca 234420cggtaatttt tttttttaag caagtgcagg gctgggcaca gtggatcatg cctgtaatcc 234480cagcactttg ggaggctgag gcaggcagat cacttgagat caggaggttg aggccagcct 234540ggccaacatg gtgaaacccc atctctacta aaaatacaaa aattagccgg gcatggtggc 234600acatgtctgt aatcccagct actcgggagg ctgaggcagg agaatcactt gaaccctagg 234660ctgcaatgag ccgatgtgga ggctgcagtg agccgagatc ttgccactgc attccagcct 234720gggtgacaca gcgagactct gtcaaaaaaa aaaaaaaaaa aaagagctgg gattccagga 234780gatcctgagc ctccaagaat gccccccttg agaggatgag tctcccagag gattagaaat 234840gcctggtgtg tttgaagagc agcaaggaag ctggtgtggc tgggcggagt gagagaacag 234900tggggaaacg aaggacagag agatgagtgg ggaggtgagg gggcaccttg tgccggggat 234960cacagagagg gctcttcggc tcttactttg agtgaggtga gggccataga gtgttctgag 235020cagaggaggg acttgatcca ggtgttcaca ggtgcccttt ggcatctgtg ggaagccaga 235080ggacctgtga gcaggtgatc acactggtcc ccatgggcga tgacggggac aggatcaggc 235140tggtgaccaa agaagaggtg agaagtggac agattcttgg aaggttctgg aaatagagcc 235200agtgagtttt gctgatagag ccaccaatga gggatttggg acaaagaggc atcaaagagg 235260atcccaaagt ttggatctaa gagccggcaa gccagagctg gcttccatca ggcaaagggg 235320ggccgcctca tggggcaggg gctccccact cctccctgga gtcctctggc cactgcccat 235380ccctgcaaga tgaggtggcc tcattggctt ccctgcctct ccccgagagg ctagagagtg 235440ggtggcagca ccccagggtg gggatcaggt gggggttctg agcaccctct cttctccccc 235500acagatgatt gacctggggc tcgtcctgca tcagggtgcc tacttccgtg acctctggaa 235560tattctcgac ttcatagtgg tcagtggggc cctggtagcc tttgccttca cgtaagtctc 235620ctcgcaaggg ttcctcttgc ctcttttccc ccaaccccca gcctgggcca cacatcggat 235680tacaggacat gttctcaggg tctagggatg gggtgtgtgg gctccgggga cgtgggagat 235740atcagcatgc caccaggaag agcttcgatg gctttttgca tgatgtccat ggaggaagaa 235800ggagaaggga ccccccctcc tgccaacctt ctacctcctc acacagcaac gggcctcagc 235860cacatcactg gccccttgct gtgcagcttc ctgtagacta gcctcgccgg aacatctcat 235920ccccctacta ctccacaagc gccgcccaaa ccgctgtctc tttggaaagt ccctaaagag 235980acaatcagga aacgaatgtg catgagaatt ctgaccccct ccctatgcct gaaggccccg 236040tagttgtaga cctggtgact ccctttgtgt gtctttcact tctcctggca gtcctaggat 236100tctctgccct ctgaaaggcc atgtgtcatc ctgcagctcc aagatggcgc cccagttgta 236160ggcagccatt tcaggatggc acccaagctc ttagtagtca tcccaagatg gcatccaagt 236220tctgggtggc cattccaaga tggcccctga gttctgagct atcattccaa gatggcctct 236280gaatttgggg tggtcattct tagatggtcc ctgagttcca aggtgacctt caagttctgg 236340gtagccattc caggatggtc cccaagctct gggtggctat tccaagatgg ccccaagttc 236400taggcagcca ttgcaagatg gcccctgagt tccagggtgg cccccaagtt ctgggcaacc 236460attccaaggt ggcatccaag ttctgggtgg ctattccaag atggcctctg atttctgggc 236520taccatgcta agatggcctc tggattcttg gtggccattc ttacatggtc cctgagttcc 236580aaggtggcct tcaagttctg ggtagccatt ccaagacggt ccccaagtct tggatggcta 236640ctcgaaggtg acccccaagt tctgggcagc catctcaagg tggcacccta gttctgggta 236700accattccaa aatggcaccc aagttctagg gcaaccattt caaaatggcc cccaagttct 236760gggtgactat ttcaagatgg tacccaacag gtgagtggcc attagccctt agggccctga 236820tagcagactt agcagtacat tcctgaagtt gtagacattt ggagcgggat gaaaaatatc 236880taatcagtct ttaatcaaga aacaaatctt ggggaccctg gctgtgccca tcatggtgaa 236940tgattccctg acaggttttg aaaggatctt gacacattca ctcccatcgt gagagaatca 237000ggggcttcct cctgtgcctc tgcctctagg ctccctcctg agccaatctg gaggggccct 237060tgaatggtct ccctcaccaa acaatgagga cttggtttgt caggagggcc aaaatagtgg 237120cccatttcca gtagaagggc tgttaagtag gccacactta gattcttctc tgggaacaca 237180atgaggtcaa gttgtgttag aacaaaaaat ctccagagtt tttggatgcc tcagagctgg 237240agatgtatca tgaaggttgg gaggctgatt atacttcttt ctctttctct ttcactcctt 237300cctcctcttt ctcctctctt tttgttcgtt tactcttttc tttttctctt ctcctctccc 237360tccccacatc cttccctctc ctcaaagctt ttcagtgtct atttgactac tagagcaatg 237420cacggtggct tacacctgca atcccagcac tttgggaggc tgagacaggc agattgcttg 237480agcccaggag gccaagacca gcctgggtaa catagggaga ccccatctct aaaaaaaaaa 237540aaaaacaatt agccaggcat ggtagtatgc ctgcactagc agctacacgg gaggctgagg 237600tgggagaatt gcttgagccc aggaggttca aggctgcagt gagccgaaat cgcaccactg 237660caccccagtc tggggaacac aggaagaact tgtctcaaaa aaataaaaag tttaaaaaat 237720taaaaatcaa tgaatttgct atttagaata ttatgcttta tatggttact gaataatttt 237780aatagtgatg agtacaaaaa aaacaggttt agcaagctgt tctgtaggtt aaaaagtaaa 237840taaataaata attaattaaa caaaatacaa tgcacatcaa attaggggac aaagattgtg 237900acgaataaga caaggagtcc atgtctttaa aatatgaaaa gcagttacaa atcaataaga 237960aacactactt ctcaatggat aaatgggcaa aggacataaa cagaaatctg atagaatgct 238020ggcaactagt aaaaatggag gtaaatcaac ccttggaatt cagagaaatg taaaataaaa 238080acgagataca attcattccc tatcaagtta gcactgttcc cgccgcaccc ccacacacac 238140acaaaaaatg atttttttag ctaataaaca gcatatataa gaatgtatta taataggctg 238200ggcacagtgg ctcacgcctg taaccctagc attttgggag gccaagggag ggggatcacc 238260tgaggtcagc agttcgagac cagcctggcc gacatgacaa aaccctgtct ctactaaaaa 238320atacaaaaat tagccaggca tggtggcgga tgcctgtaat cccagctact caggtgggta 238380aggcaggaga attgcttgga cccaggagat ggagactgca gtgagccgag atcatgccac 238440tgcactccag cctgggtgag aaagcaagat tttgtctcaa aaataaaaaa aggaatgtat 238500tataataaaa tatacttttc tccccctcta tcacctattt aagcaggtcc ttcaagttgt 238560caggtagaca tcatgctatg agaaaattta aatcctgaaa agccagaatg ttttaccacc 238620ctcagcctgg aatgaatcct tctcctatgg aaataaccta cgggtttctc cacccctctc 238680tgcctttcag ccccttccct ccctctcccc tccttttctt tctccctctt tctcttcctc 238740ctttcccctc tcttccctct ctcttcttcc ctctctctgt ctctttctgt tcgtctttct 238800ccttttaccc cctctcagtt tctatctttt tattttcctc tttctctctc tctctccctc 238860tctttctctc tcactccctg cactgttgat gacctatgtc cttgggtgat gtgggcctcc 238920cctggaccgt gtagcttgga gaaagctgac cctctgtcat cggtctggca acagggactt 238980ggccccccta ccctgcattc tgatgaggaa tggtattcag acaaaggcag atcccaggac 239040acaggaggac atgctcaggc agggaccccc gcccctttcc tctggggcaa ggtctgctca 239100gcagcctcca agattcctag ggctcaagag gtggcaggta gctcagggca ctagggcagg 239160cagtggggtg aatatgtcac tcatatccac ctgtccacac acaatgctta ccttggccac 239220ctgtgcccag gggaatgggt tttatcctgt gaatcctccc agtgaccacc actgagtgtg 239280gcacagataa atggtaccaa gcccaagctg ttcaggtctc caatgtcact ttcctctcag 239340acctctgttg tagctgacat actgtaatgc tgaggagggc cgggcacagt ggctcatgcc 239400tgtaatccta gctctttcgg aggccaaggc agatggatca cctggggtca ggagttcaag 239460accagcctgg gcaacatggt gaaaccccag gcaacatggt aaaaccctgt ctctactaaa 239520aatacaaata ttagccaagc gtgatagcag gcgcctgtaa tctcagctac tcgggaggct 239580gaggcagaag aattgcttga acctgggaag tggaggttgc agtgagccaa gattgcacca 239640ctgcactcca gcctgggcaa cagagcaaga ctctgtctca aaaaaaaaaa aaaatgctga 239700ggaggtgact gtcccacctc catcctccga gttgaccatc acaatttagg gaggggaatg 239760acctacaaag gacccagaag caagcctttc aattgttgag cttttgccat tatgggccat 239820cgtttacaac atgctgtttc taggttctct ggaggtaaaa ttagcctcct cttttaaaca 239880aagctaatct gcaaaagcga accaaaaatt cttttccacc agagatcaat tagcagaatg 239940agctgggtgc gatggctcac acctgtaatc ccagcacttg gggaggccga ggcaggtgga 240000tcacttgagg tcaggggtcc aagaccagca tggccaacat ggtgaaaccc catctctact 240060aaaaatacaa aaactagctg ggtgtggtgg ggagggcctg tagtcccagc tactcgggag 240120ggtgaggcag gagaattgct tgaacccagg aggtgaaggt tgcagtgagc caagattgtg 240180ccactgcact ccagcctggg tgacggagca agactccatc tcaaaaaaaa aaaaaaaaaa 240240aaaaaacagc agaatgattc ttttggggag ttgacttttt ttttaatttc tgagttttct 240300ttttaaatat caagttatac aagggcattc aaattggcct acaactcaca ggaatttggc 240360agcctgtttg cagagtcaag cttttacatt gttctcatga aattggtaca ggcataaagc 240420cacccttcac tcttgaaaat ccattttgaa tgttgttgtt ttaattctta tgcaagaaaa 240480ggatctggat agggatttca ggccatcctg tcaaccctgg caggcttgta gatcatgcag 240540gaactgggag gtgtgagatt ttgccagtag gatcctggca agtgcctggg actctcccag 240600ggttttggaa gagccgacgg acatgagtcc aacagggagc atctttatat catggccgaa 240660gggatgagag aggagaccct caaacctcac gcctaccaca ccctccccac cccactgtca 240720agagtccatc tggtactgct gttcctcccc cagggcaggg ctgcaggccc agcacagctg 240780gccaggtgcc ttgatcaagc cattcctgca cacctaagag ccaaactgct agaaaaccag 240840aataggagct actgcttttt tccctaaaaa gttttggaat cttctccccg ttacaggttt 240900ctggcctctt ttgcctgaga aggtctctca ccctatgagg

actttgctta ttgtctttcc 240960ttgttatcgg atagttggca cattggaagg agcatggatg ctctgaggtt ctcagcctga 241020gcgctgaact ctccacccgc cccccacccc ccaccccagg gtcctctgct tatttccttt 241080ctggtctttt aacttgcttt gtctgtcctc tgtgcatatc ccctcataga caaggctgag 241140agccccacaa gtattagatt gaccttattg ttttaagaaa ttgtccctcc aggtctgttt 241200gatttctctc tagatgtgca agtcctttag cctctctgtg cctcagtttt tcccatctag 241260atgaggaaac tgcggcccag agggactgtg gagggaagta agtccgacaa gatcactgag 241320gttgggttca gctgtcagat gctacccatc tcccagccct gaatacggag gctcacagtg 241380agcagaatga tgctcagcag cctggccagc ctgggttctt tgaggcctgg cagggctgcg 241440agatccaggg gaagggaata ggggaaggga gcataaggtt attcccttcc ttgttgaaag 241500gaaccttgcc attctggcct gttggggtca aagcaaggat tcttccccca gtgctgtgat 241560tgtggcctcg tctccgatat gggagaaaac tatccctgtg gtcccaccaa gggatgtatt 241620gaagctcttc tgaagatgtc cacccctcct gcacctcacc caaatatctg tgtgtgtgtg 241680tcctgctcaa ttcactgact gtgtcccttg tatccatgcg tctaccataa acaccccatt 241740tcatgagcca tcacacgtgg tatcacgctc tgtgcccatg catcagggcg gccaactgac 241800atttctcagc agctggcaga tcatgatcct gccctcaccg ccaagagtcc atctggcgcg 241860gctgttcttc ccccaaaggc aggaccgcaa ctggcagagc gccttgatca agctgctcct 241920gcatacccag gagccaaact gtcaggaagc caaagatgga gccctcaggc tgctatctct 241980tgatcctcat cttcaaaaca gcccccaccc ctgaaggcat tatttttctt gtgtatgatg 242040aaatggaaag aagattagag tgcgagatac ccacacctgg gtttgaatct tagtctgtct 242100tcccagctgt gtgcctgccc ttgggcaggt cactcttttt ctctaggcct cagcttcctc 242160atctggaaaa tggtcataat ggtgctgtct tcccataggc aaatgcagtg atgtccagaa 242220gactcccata ttaaacctaa agtcagcaga ttaggcaaaa atcactgtca ttgaaaactc 242280cctcaatcat ccgtaaagaa gctgggtgtg gtgtctctca cctgtagtcc cagctacttg 242340ggaggctgag gtgggagaat cacttgagcc agggagttca aggctgcggt aagctatgat 242400tgtgctactg cactccagcc tgggcgacag agcaagacca cgtctctaaa aatataaaat 242460aaagccgggt gcggtggctt acgcctgtaa tcccagcact ttggaaggct gaggcagcct 242520ggcaacagag tgagaatcca tcaaaaaaaa aaaaaaaaaa aaaaaaagta gaatctatat 242580gattctacgt atgcaataat tcctagatac actgaatttg agaaccccaa gtcagactac 242640aggaaaagga gatgaggggg tgtggaggag aatccacttg gaatatttgt agacatttaa 242700accattctgt gttttaaaaa atatcacagc cgggcgcggt ggctcacacc tgtaatccta 242760gcactttggg aggccaaggt gggcggatca cgaggtcaag agatggagac catcctggct 242820aacacggtga aaccccatct ctactaaaaa tacaaaaaaa attagctggg cgtggtggtg 242880ggcgcctgta gtcccagcac tcgggaggct gaggaaggag aatggcgtga acctgggagg 242940cggagcttgc agtgagccga gatcttgcca ctgcactcca gcctgggcga cagagcgaga 243000ctccgtttca aaaaaaaaaa aaaaaatcac taacttccag aggggtcgtg gatggaaaat 243060tccatagagt ccgcttggcg acagggtttc cgccattctg atggcggtca agtctttcta 243120acctggatct ccagtcattg ttgaaggcgc ctaatgagcc ccaagcctga ttccaatgaa 243180tcacgagagg accagctgct aggtgctgat agctttcccc aggcccgcat ttgctcagag 243240ggcttcagag ttgcttctaa ttccatccca agtcagaact ctttgctgac cccctccttc 243300ataaagagca aagccaaggc catagctttt gttaatcaaa catcagaatt ccacagacct 243360gagttggttg gttgtttgtt ttaagagaca gagtcttgcc caggatgcag tggctcacac 243420ttgtaatccc agcgctctgg gaggcctagg caggaggatc acttgagccc aggagtttga 243480gaccagcctg agcaacataa tgagaccccc gtctctacaa aaaatggaaa aatttgcctg 243540tatttccagc tacttgggag gctaaggtgg gagaatcacc tgagccctgg aggttgaggc 243600tacagtgagc caagatcccg ctactgcact gcagcctggg caacagaggg agaccctgcc 243660tcaaaaaaaa aggagagaag gagagagaca gggtctccct atgttgtcca ggctggtctc 243720gaacttctgg cctcaagcaa tcttcccaac tcgtcctccc aaggtgctgg gattatagct 243780gtgagccacg gcacccagtc tgggcctgtt ttgcagatga ggataacgag aggcagagtc 243840aggattcaaa cccaggtccc ctcaacttca aagctcacaa ccttttagac attctaaaac 243900cttgcagctc cacaacgcct ggagaagagg ggtttctccg gctcttggca gtgactttcc 243960gtggtgaatt cacctttggt aactgacagc tttgcagctg tcctgctacc tggaaatttg 244020gctttcttag tgctttcttg ggcagtgcca ggtgcctgcc aagggcgggg gactgaatgg 244080aggtgggggc ggcttccaga tggaaggatg gacatcggcc agcgccatga gcctgaggct 244140cccccaactg ctgcccgggc gggactcggg ggtgctcagg ggtgcgtgtg tgtacgtgcg 244200tgttctgtgt tcttttttct gaggccactt acgatctgtc tctccctccg atgccacatc 244260accaggagca gtacacggta aagtctctct ctatctttct ctctctctct ctttctctct 244320ctctctctct catattctgt ctctcgtgat ctgtcccctg gtgcagcctc gttagttctg 244380ggcctgtttc tgtggccttg tgtccttgct gccgctgtcc tgtcgcttca aatgaccaga 244440actcactccc tgcgaaggag gcatcccaaa gggtcttgcc aatgcctccg cccatgcccc 244500accagttctt gcagagaaca gaaggggcag aggttcagtt tcaataggca agctgggtgg 244560agcagttatc agaagcaatg aaagtgggcc agacacggtg gctcacgcct ctaatcccag 244620cattttggga ggccgaggcg ggtagatcac ttgaggtcag gagtttcaga ccagcctggt 244680caacatggtg aaaccccatc tctactaaaa atgcaaaaaa ttatctgggc ttggtggtgc 244740acacctgtaa tcccagctac ataggaagct gaggcaggag aatcacttaa acctgggagg 244800tggaggttgc agtgagctga gattgcacca ctgcactcca ccctgggtga cagagtgaga 244860ctctgtctca aaaaaatata taaaataaat tgaacaataa aaaaataaaa tggccatgga 244920atcgttttca gatgaggaga tgcagaatgc ccatggagac atgctcccaa ttgtcacttg 244980tttgggacat caagatttta gccagttcca tgtgcaacct ggatgtacag ttccttgact 245040ttttttctat caacatgtat tctaaagttc aatttcaaaa ggaaacttta gccaggtgca 245100gtggtgcatg cctgcagtcc cagccatttg ggaggctgag actgaaggat cacttgagcc 245160caggagttgg aggctgcggt gagctatgat cgtgccactg cactcccccc tgagattcca 245220tctctttaat ttaaataaaa aaaaaggaaa ctatattatc cacttacaac cagcattgct 245280aacctaagat aaatctgcaa ctgcaaaagt aaatgtaggc cagacatggt ggctcacacc 245340tataatccca gcactttggg aggccgaggc aggtggatca cttgaggtcg ggagttcgag 245400accagcctga ccaacatgga gaaaccccgt ctctactaaa aatacaaaat tagccggacg 245460tgatggcaca tgcctgtaat cccagctact cgggaggctg aggcaaaaga atttcttgaa 245520cccgggaggc agagactgct gtgagctgag atcacgccat tcactccagc ctgggtaaca 245580agagagaaat gccatctcaa aaaaaaaaaa aaaaagtaaa tctaacagaa accagacaat 245640gttgttgcct tcaagctggg ctctttgtta aaaggaaaat tactaagtgt tagggaggtg 245700ttaaaggcct attagcatct acctgaggct tcctttctcg caaaagcaga gcgtctgaaa 245760gatacgtgga aaagaaactt aaagtataat aaaaaagaaa gaaagaaaaa gaaatgatta 245820tgcccctctg agatccaatt atttaatctg tgcccctgtt ctgcctaaaa ttatctcagt 245880gactgtccaa cgtgtgtctc acacttgggg gcacagcctt gagatgataa tgatgatgtt 245940agttttaaaa agaaaaaaaa aggttcagag ttctgaatcc tggagtatat ctctgcctag 246000caggctaaaa tacaattatc gtctttgttc cctgaaaaat gaaaaaaatg gagtccttta 246060aaaagcaaat ggtgtgaaga atgatgtttt tgcactggat actgagaccc atcgtgatgg 246120gggtctctgg ggcagctctg ctcatgacct gggaggtcac tgtagggaga tgttttctag 246180gtgacctccc cacccaaata ctccaaccgg aggcattcac gtgtcctgag accacacgcc 246240aggcgcaggc taggggctag gacaagaatc aagattaaag gggaaatggc caggtgcggt 246300ggctcatgcc tgtaatccca gcactttggg agtcaaggcc agtggattac ttgaggtcgg 246360gagttcgaga ccagcctggc caacacggtg aaaccctgtc tctactgaaa atacaaaaat 246420tagccaggtg tggtgactca tgcctgtagt cccagctatt cgggaggctg aggtgggaga 246480atcacttgaa cccaggaggc agaggttgca gtaagccaag atcatgccac tgcactccag 246540cctgggcaat agagcaagac tccatctcaa aaaaaaaaaa aaagattaaa gggaaaatga 246600acacagagaa gagtagatta cactgtaagc ctttgaagag ttttctgtct aaaaccagag 246660accgaagaaa caaacaaaga ttaactccga aatagcacat aggagctggc aggagccaga 246720ggtaggcagt caggaaatgc tgtcggaggg agcaacaggt aatttgggct ttgaggaccg 246780ggtagttctg tgactggaga agtggaggaa gggcatttct agcagcggga acagtatatg 246840cataagcaga cagaggcaaa agaatgtggc tggggcttga gatatgtagc cataaatggg 246900aatgcaaagg tgaaggtaag ttggactaga ttttcaagag cattgaatgc catgcccaga 246960agtttgcact tgctcttctg agaattcacg tgctccagaa gaattctgag caagagaaag 247020agtgacaagg tcattggctt tagccactgt gtgcataaaa catggaagaa aaggcaggga 247080atgaggagca agttgggaga cgggtgaggg gggatggcac ccaggaatgg atggcgggat 247140gttaaggaag gtgacccact ggggatgggg atggggatag agggcaggca gttgaccatg 247200actctcaggt ttctggtgtg gacaactgga tgggtcatga gtgccatgaa ccacaagcta 247260ttcatggtcc cactcaatac cctcctcttg gggggcctga gtcatggttg gccaagggtg 247320tcatggcatc tctggggtct gcattgctaa gctcagttcc aacagacctt ggactgaact 247380tctgtgcagt cctctctggc aaagatgggc tcagagaccc ttggagcaat gcagcagaga 247440ccatggcagc agccacatca gcatctgaaa acagcggcac ccggttattt tccctccttc 247500agactcaggg aatatggtgg gggaggggag atttggtata agggccactt taagtatctt 247560ccagaatccc attggaaggg ggagaaaatc ccattttttt aagagcccac tgataccacc 247620tttaaaaaga atacacaggg ggccaggcgc agtggctcac acctgtaatc ccaacacttt 247680gggaggccaa ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat 247740ggtgaagccc catctctact aaaaatacaa aagttagctg ggcatggtgg cacgcacctg 247800tagtcccagc tacttggaga ggctgaggca agagaatcac ttgaacctgg gaggtggagg 247860ttgcagtgag ccaagatcat accattgcac tccagcctgg gcaacaagag tgaaactcca 247920tctcaaaaaa aaaaaagaat acatagggga ccactaaact cctagaccaa gggctttttt 247980gaaaatagct gtgaccaggt gtagtggctc acacctgtaa tcccagcact ttgagagggt 248040gaggagggca gattgcttga gctcaggagt ttgaaaccag cctgggcaac atggtgaaac 248100ctcatctcta caaaaagaca aaacaattag ccaggcgcag tggcgtgtgc ctgtagtccc 248160agctacttgg gaggctgagg tgggaggatg gctttagccc aggaggcgga ggttgcagtg 248220agccgagatc gtgccactgc actccagcct tggtgacaga gccagaccct gtctcaaaaa 248280agaaaaaaga aaagctgtgc agaaatgggg gtggggaatc agccaacccc cttgtgctgg 248340gtctcaggga cacccaatac agctgctcag gcccagccag atggcaaagg gccctcaacc 248400aaccctggga ccagaaccac aaaaagccac gtacttactg gctcccgagc ccaagcttaa 248460caggtgaaat ggaccactct tcaccaggaa gggcagggct gtgccaagct caccccagac 248520ttctaggcct gggagggtag ggtcccatgg agctgtgggc tgccccctac ccaacctgac 248580ctctgcttcc tctcttccct tcttcccacc taaacattcc tccacagtgg caatagcaaa 248640ggaaaagaca tcaacacgat taaatccctc cgagtcctcc gggtgctacg acctcttaaa 248700accatcaagc ggctgccaaa gctcaaggtg agattgggag atggtggggt gcggtggggg 248760ggactgtcag ggttatcatg tacagctgag caggttgtac actgctcaag gacaacacat 248820taaaggaggt gctgataaca tcctagccat cgtgtatgga tatttgtatt attacaactt 248880cccagcagat ggcagtaaag tgagctgacc taaaataatc tgtgtattat ggcagttttt 248940ctttagatga agtgtcttgg ggttaagatc ctttttccta attcgcatga aggcatcata 249000tggatttaaa agggtataac cgtgatctgg gaagcaggaa ctagatttct tgttccataa 249060aattttgact tttcatctac ctattctagg ctctagtatc tcccattcca aaatagcatg 249120aaccagcatt tcccaaaagc ctgtcattca aaaacatata tatatattaa gggaaataaa 249180atccagtcat tagagcaccc actttcactc tatgcttcac ctgggggtcc ccagtattat 249240ctcttatgta atatgtttct ttaaatcaag tcacacccgt aatccctgca ttttgaaaga 249300ccaaggcagg agtgttgctt gagcccagga gaatgagacc agcctgggca acatagttag 249360actctgtctc tactaaaaat taaagacaga aaacagatac tgttatggaa atctaaccaa 249420atatggctgc ctgcctaagg ctttgtgcat tgacaactgc tctttcttgg ttaaagaggg 249480aaaatgtcaa tggtaggtgt taacatggta gcaactaagt aaaaatttct ccttcactca 249540aaaggattga gagagttgga aaggaagtaa ctttgttacc ttgtttttct gtgttgggct 249600cctgtatcac ttaaaagcat ctctggtatc ccatctggga gttttagatc catagaatgc 249660caggattgag tccaactcct ccaacgctta tttctgaaag ctggggggac cttaccctag 249720tgacttgact tatgaccttg cctgtaaaat gggaatgatc atggcagtat tttggtatga 249780tgggccactg gaggcagaag gttgggcagg tccccagccc ctcatgctct ctgtcaactc 249840caccccacag gctgtgtttg actgtgtggt gaactcactt aaaaacgtct tcaacatcct 249900catcgtctac atgctattca tgttcatctt cgccgtggtg gctgtgcagc tcttcaaggg 249960gaaattcttc cactgcactg acgagtccaa agagtttgag aaagattgtc ggtgggtctc 250020cactttccag cacattccca ttggaaccag caggtgggca ggggggaagt ggctagaggc 250080attggccact tgggctcaga gactggagaa gtgatgagcc ttggaagtga ctcagttgca 250140accagcttgg atcttgggta gaaagaaaac cggttttaga atttgagtca ccacccagag 250200ccacagaatg agtcataagc aaattgattg acctttcagc caccgccttt gtcatgtgag 250260ggatattaat acacatccac agttccttac ttgaaatcgt tacaggcaga tgtgtttcaa 250320agttgagaat attttgagat tcccatgtgg gacatgacac cctcagctgg gtctaaggca 250380gccctataat caaacacaat atttctgcca taaaatgtgt aactatttac atcaaatggg 250440gtaaataaca agtataaaga gcttcatgtc caatcagatc aggtttcatt accaaataag 250500ttaggtaaga ggccaggtgc agtggctcac acctgtaatt ccaacacttt gggaggctga 250560ggtgggagga tcacttgagg ccaggagttg gagaccaggt tgggcaacat aatgagagcc 250620catcctacaa aataaatttt aaaagttagc ggggcatggt agcacacacc tgtagtccca 250680gctacccggg aggctgaggc gggaggattg tttaaacaca ggagttcaag gctgcaatgc 250740actatgatgg taccactgca ctccagcctg cgtgacagag tgagaccctg cctctcaaaa 250800atatatacat ataggccggg cgcagtggct catgcttata atctcagcac tttaggaggc 250860cgaggcgggc ggatcatgag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc 250920ctgtctctac taaaaataca aaaacctagc tgggcatggt ggcagacgcc tgtagtccca 250980gctacttggg aggctgagac aggagaatgg cgtgaacccg ggaggcggag cttgcagtga 251040gcccagattg ggccactgta ctccagtctg ggcaacagag ccagactcca tctcaaacaa 251100acaaacaaac aaacaacaac aacaaaaata tatatatata tatatgtata tatatatatg 251160tacacgcaca cacacatatg tattatatgt gtgtgtgtat atatatgtat gtgtatatat 251220agtgatattg ttaccagtgt aaagtggcat tttgcaacac atggtagcct gttgttatct 251280tgatggctat ttattgaaat taggaggatg ccagatgtct ggataggagt ctggaactaa 251340cccttgtttc ctgccttgaa aaggagtagc aacctccctt agcctgatga acctctaaat 251400gtcccctatg tctctctgcc tcctcctaaa ctccctccac cccaccccca gcaagcctga 251460ggctctcacc ctgaggacta gaagttatca cgttggaaga gggtgctgga ccctgggtca 251520gctctcccac caggagtaag gttgtgccat cacccatgga tttatctcaa agtagatgca 251580cacgtcatcc cctatgaagc acaggaacac atggtggcag gatggggagt cactgcttcc 251640caagcagtct aggctggtgg accactcttc ctttccctcc ccctgtctct gataaccaaa 251700gacaagtgca agacagcccc tctttcccat ttactaacag tccccactct ctgtggcaga 251760ggcaaatacc tcctctacga gaagaatgag gtgaaggcgc gagaccggga gtggaagaag 251820tatgaattcc attacgacaa tgtgctgtgg gctctgctga ccctcttcac cgtgtccacg 251880ggagaaggct ggccacagta agtggcccga ctggaaatct atccaggagg agccctgggg 251940agcaggagga taaagggcct gagagcttag caataagaaa ggtcttggag gccgggcatg 252000gtggctcacg cctgtaatcc caacacttta ggaggccaag gcagatgtat cacttgaggc 252060caggagtttg agatcagcct ggccatcatg gcaaaactcc atttctacta aaaatcccaa 252120aaaaaaaaaa aaaaaaaaaa aaaaaaaagc tgccaggcat ggtggctcac acctgtggtc 252180ccggctactc aggaggctga gacacgagaa tcacttgaac ccaggaggca gaggttgcag 252240tgagccgaga ttgcaccact gcacttcatc ctgagtgaca gagcaagact atggcctccc 252300cgccttcaaa aaaaaaaaaa agtgaggctg aatcatggac ttagtcttta tttaaaattt 252360tgagccactt gtggtggctc atacctgtta tcccagctac tcaggaggct gaggtgggag 252420gatcgcttga gcccaagagt tcaaggctgc agtgagctgt gattatgcca ttgtactcca 252480gcctagacaa cagaaggaga cccctatccc tgaaaaaaaa aaagaagaag aaattgatat 252540ttgttcatca tggacttttt gcattaattt tgatttttta aaatattgga gcaaaagatt 252600atcttgatta ctgagatttt cagtaccccc ttaatttgca cccaaaacaa atgcctccct 252660ccctcacctc gtccaagtaa tggtctttct ctcagaggtc ttggaaatgc caggctggaa 252720gcttggtaga ttccagcatg tgccctcagc atcctcacct ccctccctct ctcagcaaat 252780atgccaacct gaacatgccc tactacccac tctcagacac atccagtact cacacatgtg 252840ggaataatgc taacccacaa ggcacctttg agcaaagttt ttttaaacac ctttctcaac 252900agacttcatt tccatctgtc tgaaaatcat cgcaatagac ttaaatgatt ttgttcaaac 252960aaggcactga aggaccacct gccaaaaaat tgtcatcatg aatacacaaa tctatcatgc 253020ctatcatgtg aaggtatcgc ttagacacag agcctttgag cagtgtgcaa cctgcactac 253080tgtacagagc tgctgtgcac ttacccactc tcatatatat ccccattgta cctcctgagc 253140acccagcacc acctgtgctc aaatacccac tctacatgca tacacccacc tctactccct 253200ccattgccac aacctgtctt taaatcccaa cttggccact tataagtggg tggtcttcag 253260cacgtccctt taaattgctg aacctcaagt tcctcatgtg caaagtggag ccagtaataa 253320cctccctggg agggttgctg agccggtggg gatgaattgt tgaatattgt ttccagcaca 253380cagcaagccc ttcatgcaca gcagtagaaa tgactgacat tggccaggcg tggtggctca 253440cacctgtaat ctcaacagtt tgggagaccg aggcaggtgg atcacctgag gtcaggagtt 253500caagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaataca aaaaaattag 253560ccaggcttgg tggcgcatgt ctgtaatccc agctacttgg gaggctgagg caggagaatc 253620atttgaaccc gggaggcgga ggttgtagtg acccaagatc acgccgttgc actccagcct 253680gggcaacgag agcgaaactc catctcaaaa aattaaaatt aaaattaaga aataactgac 253740attgttgtca gcctttcaaa aaacagcgac tacttaaatt tctttttcat ttccctctgt 253800tcctgttctg ccatctcact tccaccctct ctccaccttc ctcatcaccc cttgggtccc 253860tgtctctctc cttcctgccc cttccctctc cctgccccat tccttgcagg gtcctcaagc 253920attcggtgga cgccaccttt gagaaccagg gccccagccc cgggtaccgc atggagatgt 253980ccattttcta cgtcgtctac tttgtggtgt tccccttctt ctttgtcaat atctttgtgg 254040ccttgatcat catcaccttc caggagcaag gggacaagat gatggaggaa tacagcctgg 254100agaaaaatga ggtgccactt ccaattccat ctgtccttta aaaactgggg acacacacaa 254160actttaaaac acacacaaca cccaggaacc cctttctagg ggtacctggg ggagggaaca 254220gaagcattgt cccaaccgaa tccagtcttc agggcagccc ttcatggagt ttccagagga 254280aacacatcat atagtgtatg tatcagtcag tttagactag gttatgccgc agtaacaagc 254340aaccccagat ttcattgcca aatatccaca aagggactta ttttttgctc acactgcatg 254400tcaacatcag ttgtggatct tgccatcttt attctggttc ccaggctggc agagcagcag 254460agcagcctcc ctctgagatg ctccagatga aaaagagagt atgtcagact gaggttcagt 254520tcttcaggct tgtgctcaaa aattacacat gtcacttctg ctcacatttc atcagccaaa 254580gcaagtcaca catccattct gacatcagtg gagtgggcaa atacaatctc ccctagcgaa 254640gggtggtgaa tatttatgaa tgaaaagcca agccaggtgt ggtggctcac acctgtaatc 254700ccaacatttt gggaagctga ggcaggagga tcacttgagc tcaggagttt gagaccagcc 254760tggccaacat agcaagaccc catctctact acaaatcaaa aaaattagcc aggcaggatg 254820gtgcacacct ttagccccag taacatggga ggctgaggtg ggaggatgct tgagcttggg 254880agttcgaggc tgcagtgagc tatcattatg ccactgcact acagcctggg caacagagca 254940agaccctctc tcaaaaaaag aaaaggaaag aaaatccagt cccctgtcta ccagagagta 255000tagacatgac tctttgcctc tctggcatca tccaagctaa atagaggacc tagaatatat 255060cctctgctcc cttgaccctt aagacttaat aaccactatt cctccttctc tctccctcaa 255120agagaaggag aagacgcagc aaagtattca gtaagaaaga atgggctggg cgcagtggct 255180cacgcctgta atcttaacac tttaggaggc caaggcagga ggattgcttg agcccggaag 255240ttcaagacca gcctgagcaa catagtgaga ccccatctct atgattaaaa aaaaaaagtt 255300ttaattagct gggtgtggtg gtgcacgcct gtagtcccag ctactcagga ggctgaagcg 255360ggaggatcac ttgagtccag gaggtcaagg ctgcagtgag ctgtgattgc actgcactcc 255420agcctgggtg acaaagcaag cccgtgtcaa agaaaaaaaa aaaaaaagga aggagggagg 255480gagggaggga aggaaggaaa tgagagagag aaagaaagga gggagggaag gaaggagata 255540gggaagaagg aatgaagaag aaagaaaggg agcgaaggaa agaaggaaga agagagaaag 255600gaaaggagaa aggggaaagg gtggaaggaa tgaagggaag gaaggaaaaa ggaaagtgaa 255660ggagggaggg aggaaggaag gaaaggaggg agggaaggag ggagggaagg agggagggag 255720ggaaggaggg agggagagaa ggagggaggg agggaaggaa ggagggagga aggaaggaag 255780gagggaggga gcgagggagg gaggaagggg aagaaggatt aggcttcaat ttgatttggc 255840acactcggta gctgtgtcac ctcaggcaag tggtttaacc tttctaagcc tctattttgg 255900tgatctgcaa agtgaggcca ttgatagtac ccacttccca tgtttgtatt agccatgcaa 255960taatggggaa atgtcagtgc aagttttggc agttggtgac

atctcaagca actgtagctg 256020ttgggataag aaagcaatgg tgagaaggaa gagagagccc aggaatcctg gctgggggca 256080agagaggcag agactcaagc agaagcactt gagaaccgcg acgagttaga cagagggtgc 256140ccggtgtaca gccaccttcc tcctgcctct gccgctctca ccactggcct ctctcccgca 256200gagggcctgc attgatttcg ccatcagcgc caagccgctg acccgacaca tgccgcagaa 256260caagcagagc ttccagtacc gcatgtggca gttcgtggtg tctccgcctt tcgagtacac 256320gatcatggcc atgatcgccc tcaacaccat cgtgcttatg atgaaggtaa gtgccccaca 256380ccagccccca gcactactta acccccacct cgttcctgcc tctaccctga taaaatgaaa 256440ccatctgcag tttcccagac agaccacact ctggatcacc tctgagattt tgttcctgct 256500gttccctcta cctgacacac tgttcccacc actcccccgg ccagcttctt cttcccagct 256560gtacctgcag acctcttcct ccagaaagcc ttccctgacc acccaagact gcttgaggtg 256620cccatcttag caggcatcct atctttatgt cgcctgccac aaaaatctgc gtcaggttgc 256680atgacagtgt cccccaccca tttatgatga cctcagccct gaattcctag aggccaacaa 256740ggatctggct cagacggaac aagaagctct ctataaatgt ttgattaatg aaatgagggg 256800gctgggcgcg gtggctcatg cctgtaatcc cagaactttg ggaggccgag gcgggcggat 256860cacctgaggt cacgagttcg agaccagcct gaccaacacg gagaaaccgc atctctacta 256920aaaatacaaa attagccagg cgtggtggtg cgcatctgta atcccagcta ctcgggaggc 256980tgaggcagga gaattgcttg aacccgggag gcggaggttg ccatgagccg agatagcgca 257040attgcactct agcctgggca acaagagcaa gactccatct caaaaaaaaa aagaaaagaa 257100aaagaaagaa atgagggaga aggggtaggt gaggacccta aaatccccag ggctaaggag 257160cggcttccaa aaaaaaactc tgaaaacctt tcaccctgtg ctttggactc caaagcgtgg 257220attcaagccc agctcttcca tttaattcat ttacctttgt acaagcaacc agtgactttc 257280tggggactca gtttccctgt caataaaatg ggaatgataa taagagcaca tttgccccct 257340ccagaggagg tgagaggatt gaatgagaaa gttcatgcaa ggaccttagc tccttctcgg 257400cacttcaaaa acgatcaata gtggccgggc aaggtggctc acacctgtaa tcccagcact 257460ttgggaggtc gaggcaggcg gatcacttga ggccaggtgt tcgggaccaa ctggccaaca 257520tggtgaaatc ccgtctctac taaaaataca aaaattagct gggcgtggtg gcgcatgcct 257580ataataccag ctgcgtgaga ggctgaggca tgagaatcgc ttgaacccag ggggcggaag 257640ttgcagtgag ctgagatcac accactgcac tccagcctgg gtaacagagt gagactccgt 257700ctcaaaaaaa ataaggaagc cggggacggt ggctcacgcc tgtaatccca gcactttggg 257760aggccgagga gggcgatcac aaggttagga gatcaagacc atcctggcta acacggtgaa 257820acgctgtctc tactaaaaat acaaaaagtt agctgggcat ggtggtgggc acctgtagtc 257880ccagctactt gggaggctga ggcaggggaa tggcatgaac ccaggaggtg gagcttgcag 257940tgagccgaga tcgcgccact gcactccagc ccgggtgaca gagtgagact cctcaaaaaa 258000aaaaaaaaaa aaaaagtata attcagccaa gcacaatggc gtatgcctat agtcccgact 258060atcaggaggc taaggtagga ttgtgagttc aagcccagcc tgggcaaaat aggaagaccc 258120cgtctaccaa aaaaaaaaaa aaaaggttgg gggaggtttt tgtttttttg gatgtgaaaa 258180gaagagccta gtccggcgga gagcggggct ttcctgaact gtgcctccta ccagtgaggt 258240tgctcagacc ttgcctgggg ctggagtgtt gcctggagaa cagccatgaa gctgcctccc 258300cacttcccac ttcccacccc tgctcgctga cccctgctac tcctgcttct ttcccctagt 258360tctatggggc ttctgttgct tatgaaaatg ccctgcgggt gttcaacatc gtcttcacct 258420ccctcttctc tctggaatgt gtgctgaaag tcatggcttt tgggattctg gtaagtacca 258480ccttggggct acagctatgg gcttgggaga agcccaaggg ggaacaatgg gtcctggatg 258540atggtctccc aacgtggccc caagaacccc aacctcaagg gtggcttcag tatcctgcca 258600gtggccacag atcctactta ggcattcttg tgtttgccaa ggagtcccag ggagacccaa 258660cctgtgagtg ttaccatatg gctgcttatg tatccagttc ctcaaaatga tgggagtcat 258720catggctggg agtctttagc atccatttta gagataagaa aactgaaatc aggctgggcg 258780aggtgtctca tggctgtaat tccagcactt tgggaggcca aggtgggcgg atcacctgag 258840gtcgggagtt cgagaccagc ctgaccaaca tggagaaact ctgtctctac taaaaataca 258900aaattagccg ggtgtggtgg cgcatgcctg taatcccagc tactcgggag gctgaggcag 258960gagaatcgct tgaacctggg aggcagaggt tgtggtgagc cgagatcaca tcactgcact 259020ccagcctggg caacaagagt gaaactctgt ctcaaaaaaa agaaagaaag aaagaaaact 259080gaaatcaggc tgagcacagt ggctcatgcc tgtaatccta gcacttcagg aggccaaggc 259140aggaggatcg cttgaagcta ggagttctca accagcctgg gcagcaaagc aagcccctgt 259200ccctacaaaa aaaaaaaaaa ttttttttta attagccagg catggtaact cgtgcctgta 259260gtgccagtta ctcaggaggc tgaggtggga agatattttg agcccaggag gtggaggttg 259320cagtgagcta tgatcatgcc actgcacccc agcctgggca acagcaagac tccatcttta 259380aaaaacaaac acagaggtca ggcacagtga ctcacacctg taatcccagc actttgggag 259440gcagaggcag gcaaatcact tgagcctagg agttcgagac caccctggcc aacatggcaa 259500aaccccatct ctactaaaac tacaaaaaat tagcctggcg tgcttgtggg tgcccatgat 259560cccagctact caggaggctg aggcaggaga atcgcttgaa cccacaaagt ggaggttaca 259620gtgagctgag atcacaccac tgcactccag cctgagcaac agagcaagtc tcaaaaaaat 259680aataataata aaaataaata tgtctttatt tttcaccagc cactaactaa attttaacat 259740ttccttccat cttaaaggga gataacaaac ccttagtatt agtattatca acccttaata 259800ttatcaacat gacctgtgtc acttataaac atcagatatt ttcatactgc attataagag 259860ctgcagatac cttaacattt aatttgcatt catcattgct ttaaaatgtt gcttgtgatt 259920aaacctacag ctagaatttg ttactcagtg tttttttgtt gttgttctgt tttgttttgt 259980ttgagacagt ctcgctgttg cccaggctgg agtgcagtgg cgcaatctcg gctcactgaa 260040agctccaccc cctgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta 260100caggtgcctg ccaccacacc tggctaattg tttgtatttt tagtagagat ggggtttcac 260160catgttggcc aggatggtct tgatttcctg acctcatgat ccgcccgcct cggcctccca 260220aagtgctggg attacaggcg ggagccaccg cacccggcct actcagtgtg ttaatggaga 260280agtatattca ttgttagatc gccattttta aaactttttt tttttttttg agacacagtc 260340ttgctctgtt gcccaagctg gagtaccgtg gcacaatctt ggctcactga aacctccacc 260400tcctgggttc aagcgattct cccatctcag ccttctgagt agctgggact acagatgcac 260460accagcatgc caggctaatt tttatatttt tagtagagac ggggtttcac catgttggcc 260520aggctggtct cgaactcctg gcatcaagca atctgcctgc ttcagcctcc caaaatgctg 260580ggattacagg catgagacac tgtgcctagc cttaaaaaat attttgatag ctattttatt 260640acaaaaggta accttgaagc ccttgctatt ttgttatgca tttacaagcc tttatgcata 260700aaataaaata gccagcacta ttctcacatg gccaaggttc atagcacaca cacaaaagta 260760tagttggctg agtgcggtgg ctcacacctg taatcccaac actttgggag acagaggtgg 260820gtggatcatg aggtcaagag atccagacca cccttgccaa catggtgaaa ccccatctct 260880actaaaaagt acaaaaatta gctgggtgtg gtggcgcatg cctgtagtct cagctactcg 260940ggaggctgag gcaggagaat catttgaacg tgggaggcgg aggttgcagt gagccgagat 261000cttgccactg cactccagcc tgggtgacag agtgagactc catctcaata aataaataaa 261060ttaaattaaa ttaaattaaa attatttttt aaaaaattgg gggctgagtg tgatggctca 261120cacctgtaat cccggcagtt tgggagcttg aggagggcag atcccttgag gtcaggagtt 261180caagaccagc ctggacaaca tggtgaaacc ccgtctctac taaaaataca aaaattagcc 261240aggcatggtg gcgtgtgcct gtaatcccag ctactcgtga ggctgaggcc caagcatcgc 261300ttgaacctgt gaggcggagg ttgcagtgag ccaagatggc accagtgcac tccagcctgg 261360gtgacagagt gagactttgt ctcaaaaaaa aaaaaaaatt aaggtgaaga aggcttatac 261420tagtgggctg ggacttgaag tgaagtgaat tcttgaaggt ccccagtgag tggccaaggt 261480gggacttgaa ccaggacatc tgttctcttg accaccagct tagtccatcc ctttgaagag 261540agtgacctac agtctgggtc tcagccaggg tctcaggaaa ccaggttccc accttggctc 261600acggaggtgg ttaggggcat cagctttagc accagagttc agatcttgcc tcgtcctata 261660taagctttgt cacctcccca tcattaaaag gagccatcct ccccctccac ctcagcagag 261720ccctggtaaa cagcaaatgg actaacgtgc atctagaggg ttgaggatga agcctggcct 261780ggcatgggca ctcaataaat gctaggggcc aggcacggtg gctgacacct gtaatcgcag 261840cactttggga ggctgaggca ggtggatcgc ttgagcccag gagtctgaga ccaacctgga 261900caacatagtg agattctgtc tctacaaaaa gtacaaaatt agcctggtgt ggtggcgtgc 261960acctgcagtc ccatctactt aggaggctga ggtgagagga tggattcagc ccaggatgtc 262020agggctgcag tgagtcgtga ttgagccgct gcaccccacc ctgggtgaca gagcaagacc 262080ctgtatcaaa ataaataaat aaatgctagg aaagggatcc tactaatgga cctttttcct 262140ccaaaacagt ggctttcatt tggtggagat gctacttatt agaagcactt gaggccaggt 262200gtggtggctc atgcctgtag tcccagcact ttgggacttc tgccaaggca gaagaattgc 262260ttgaacccag gcgtttcaga ccagcctggg caacatagca agacctcatc tctagaaaac 262320attgaaaaat tagccagcat agtggcacat gactgttgtc ctaactactt aggcgaaggc 262380aggaggatta cttgagctca ggagttcaag gctgcagtga gctgcgatca catcactgcc 262440ctccagcctg agcaacaaca caagacccgg actctaaaaa tcaaaaaaga agcacttagg 262500gaaatttctt aaaattaaat gataccctga gcaaacccct agatgttctg attcatttgg 262560tttggtgagg tgggagggaa tcactgaatc tgtaatttat tattattttt ttttttttga 262620gatggattct cactctgttg cccaggctgg agtgcagtgg tgcaatcttg gctcactgca 262680acctctgctt cccgggttca agcaattgtc ctgcctcagc ctcccgacta gttgggatta 262740caggcgccca ccatcacgcc cggctaattt ttgtattttt agcagagacg gggattcacc 262800acgtcagcca ggttggtctc caactcctga cctcaggtga tccgcctgcc tcggcctccc 262860aaagtgctgg gattataggc atgagccacc gtacctagcc tgcagttatt ttattctgag 262920ttgatcttct gctggtgaag tgagtcttcc actggggcct ggagctgcat ctccctcacc 262980ctgccaatcc tgcaagagcc agcactgagc ttcccctctg ctttctcttt tttttttttt 263040tttttttttt tgagatggga tcttactctg ttgcccagcc tgttcttgaa ctcgtggcct 263100caagcagttc tccctccttg gcctcccaaa gtgctggaat tataggcatg agccaccacg 263160cctggtctcc cctttcagtt ttaaatgaag ccacaagttc cctgtataac atttgggaga 263220tagaggggag ctctctagcc taggggttga ggtctgtgac caaacgccta taaagttgtc 263280tttgtttgga ctcccccaga agcagagcct gagacaagga ttgagtgcaa ggaatttatc 263340tgggatgcag ggcagtaagg gagagaggaa gtgacacagg gacagaaagg caaccaggaa 263400agagtgtatt attaagccag ttcctgctgt gaacaaatgg ggctcagttt cagtggatac 263460ctccaggagg caacagagag cacataccac agagtcatcc cacctcacag ggagggaatt 263520ggagtattta tcctccagtg cccatcagac ataatcacag gccactccca ggggagctat 263580taattcccta acacttgtgc agccacagag agaccctggg caaagtagtg tacctcaggt 263640gtgtagttga gctatgggca gggccccagc aacacctgcc aaaatgccaa aagtgccagt 263700gggacctgaa ttccttttta tttatttatt tatttattta tttattttta tttatttatt 263760tttgacggag tctcgctctg tggcccaggc tggagtgcag tggtgcaatc tctgctcact 263820gcaagctctg cctcccaggt tcacgccatt ctcctgcctc agcctccgga gtagctggga 263880ctacaggcgc gcaccaccac gcctgcctga tttttgtgtg cgtgtatttt tagtagagat 263940ggggattcac catgttatcc aggatggtct tgatctcctg acctcgtgat ccgcccacat 264000cggcctccca aagtgctggg attgcaggcg tgagccaccg cgcccggccc cctgaattcc 264060ttttttaggc agttgtgaaa caacaacatc ccatctgttg ggcacctact gtatattcca 264120tgctcagcga cgcacattca ttgtctgatt gctgtgttac cactgccttc cagagaaggg 264180cgcagaggcc ccaggcactt cgcctaggag ggaagcacag ctctaaggtc aggctccttc 264240tctgtaaggt agaggggcta cttcagggtc acactgaccg ccccaacccc tgacctggcc 264300tctgcttctg cgaagatgct gagaaggccc tgtgttttgt gttttgggtc ccactgaccc 264360cagaggggag ggccatctct ttgacccaga ctcttggatc caaactgggg tgccacccat 264420caccatgtca gtacccggtt gaggggagtc agagatagca ggagaccttg tgggacttga 264480ggctgtgact gttctccaaa caatgtggag tatttccata ttttaacaaa agagaggcca 264540ggcgtggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg atggatcaca 264600acgtcaggag atcaagatca tcctggctaa catggtgaaa ccccgtctct actaaaaaat 264660acaaaaaatt agccaggcgt ggtggtgggc gcctgtagtc ccagctactc aggagactga 264720agcaggagaa tggtgtgaac ccgggaggca gagcttgtag tgagccgaga acgtgccact 264780gcactccagc ctgggcgaca gagtgagact ctgtctcaaa aaaaaaaaac aaacagagag 264840gttatgcttg tgtttcccct tgagccagca cccagcccag gaatgcagca gtcaggatag 264900atcaagtgaa gctgcagtaa caaacagccc ccacatctca gtgacttaaa ttgatgggaa 264960gggtttttta cattcagcag ggaagctgtt tgcctcatag ttacccaggg acccaggctc 265020acagagtagc tgccattcaa aatgttactg gtcgccaagc ccagggttga gaggctagag 265080agtccaacac tgaccagaaa gtgaccacac tgcttccaca cacagcacat cactgcacct 265140agacacacat ggccccatct aaacacaagg ggaccaggaa gtgcgtgtgc ctgaaaggcc 265200ccaaagcccc gtccagtgcc tgttctgcac cctgttactg tccgcctcca gatcaggaaa 265260tggaggccca gagaggttaa gccacttgcc catagccaca cagctgtggt agcagagctg 265320ggatttgaac ccagagtctc ctttctttgc gagtatgctg ccaacctagt ggggacctga 265380acacagactg tgggctctct gaggcctggg ttcaaatcct ggctttacat ctctgtgctg 265440ctagcctcag gcagatgagt ggcttggtta cctcctagaa aatgggtata cctgggagtg 265500gtggctcacg cctataatcc caacactttg gaaggccaaa gtgagcagat cacttgaggt 265560cagaagttcg agaccagcct gaccaacatg gtgaaacccc gtctctacta aaaatacaaa 265620aattagctgg gtgtggtggc atgcacctgt ggtcctacct acttgggagg ctgaggcagg 265680agaatcgctt gaacccagga ggcagaggtt acagtgagcc gagatcgtgc cactgcactc 265740cagcctggat gactgagcga gactccatct caaaaaaaaa aaaaaaaaag agaaagaaag 265800aaaaagaaaa tgggtgataa cccttccctc caggatcttc atgaggagct cagtgatgtc 265860atttataaag cccctggggt ctcgggagcc ctcaaaaatg ctggagagac aggccacagc 265920tctgaagagc agccccagcc ctgtggagct gaagcagggt ctggaggccc cctctggggc 265980caggccaatc atgggaaggc ccccaggagt tcccagggag ggagactcag cacagatgat 266040gtcgaacagc ctttaccgca gcccttcgaa caaccataac tgtcccgggc actccgctga 266100tgggcaactg tgcctctaac atgcacccgg ccagcctagg gggccgggaa ccaagccctc 266160tgttggcatc tctgtcttgt gggtccccat tctagaatta tttccgcgat gcctggaaca 266220tcttcgactt tgtgactgtt ctgggcagca tcaccgatat cctcgtgact gagtttgggg 266280taagtctccc tccagcttct ctctgggtga ctctgggctg gacgaggcag gcggcagggg 266340gcgggggagc ggtcccagag gcagtgtgtc ccggaagcca tagctgcttg agccagcact 266400tggccatgac cagagaggga gaactggggc cccggggaca agggcagccc ctcaggaggg 266460cattgtgggg agatgggggt aaccaaagct tggctgtagg gccagcactg aggggtgggc 266520tttcctgcat cctggcctag gaattaataa tgcagatgag tacactgagg gaactgagac 266580actcaaaagc tctgaaagct gagccggctc ccaaacacca ccctatgtca ggagcccaga 266640aagaatgggt ttcaagtcaa ttctgtttga accaaccctc tcctagttag tgggcaggag 266700agagccacag ccctcaggcc agtgtgggga caccactccc agggccatag aggggtcccc 266760agggtgtctt ccctcctcta gccccgggcc tgggagactc tcaacatggg agtctctgga 266820cctctctgtg gtggccccac aggccacatt gcccttctcc ttttctggaa gactcagggc 266880cccagaggtc ctgtcctaga ccctctcctt ggccatctgc caatgagccc aggcttgggg 266940tccctcagga gattgggggg agggtagaag atccttgcag ggggaagcaa tggtcaaaaa 267000agggtgtcaa agccaagggt caagggtgat accaatgtca tcttactaac aataaaaata 267060acaatagctc acgagaatcg cagccttgct gtgtgccagg gaactgtgcc aagtggttta 267120cgtggattgg ctcagggtag aggtcttggt ctcagctcgt aagagaattc cctcggaggg 267180ttcaactgaa ggcacccaaa tgcagacctc actggtggag gggaagggaa gggtacccac 267240aagggtggca aggtgtccag cgaccaccca ccgtggggag ctgtcacctg cccaggtgct 267300gaagtgggga gggaacctga gccggaggcc aggagaagcc accaagtggg agctgtcctg 267360tcaatgtgga gagacagaga ccagggccca agcaggcaga gagcaatagg ggagaaacac 267420cccaaccttt ctctcccctc atcccttatc tcctgccaga gcctcccatg gcccaaagta 267480aaccggaagc aagctgaata tgatgctcag agcaggcagg gaagtcagga gaatagatct 267540gggtgtggtc gggcctgagg aagagggtgt tgcctcattt cacagatggg aaaactgacc 267600tcagctgggc acggtggctc atgcctgtaa tcccagcact ttgggaggcc gaagccggcg 267660gatcacctga ggccaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta 267720ctgacaatac aaaaaaatta gccaggtgtg gtggtgcatg cctgtaatcc cagctactcg 267780ggaggctgag gcaggaaaat tgcttgaacc cggaaggcgg aggttgcagt gagcgacggt 267840cataccattg cactccagcc tgggtgacaa gagcgaaaac tccatctcaa aaaaaaaaag 267900aaagaaagaa aactgatctt caatgcctgg ggaagtgaga gacactccca aggtcacaaa 267960gccaggcctg ggtgactcct gagagtacac tgacagctcc tggggtgtcc cagtcagatc 268020cccctacaga aaaggatctg tttgcctgct cttccgtcct agaaggccag gaggggctgg 268080ggaactacac aaaagagggg gccattcttt gatatgtcct acggcacccg cacccaagtg 268140atacacactt atttgccttc agctccagtg agccagaatt ttccccttcc cctcacccta 268200tccctgaaac cttcctctag agggttcttg cccacatggg ggctctctcc actggggtgc 268260ccccacctgg tcattctccc ctgtcctgag tttctagaga gggctggagc tccagctggc 268320aatcaaaata tcttgccatc cggctacata caagacagcc ttgaaccaat gtccctttgg 268380gtcaagaggt tagaaggatg gtccagctcc ccagaagggc aggtggggtg gaggaagtta 268440gctgaaacct tcaatcacca gtaagagagc tgtagggaca gactccaaca gcctgttctc 268500ctggctggca ggaagatggg gcatggggtg ttcatgggac atcaggaccc ttgcagtagc 268560caaacagccc ccagccctcc ctaccagctg tttgatcttg gacaacttgc gctatctctt 268620ctcatgtaga gtggggctaa ccattgcaac caacctcaga cacttgcaag actcacagtg 268680atgcatgcac tcaaaagaca ttcattgagc acctactgtg tgcctggtgt gattataagt 268740gctggagaca gaacgagaag gaggggtgcc aaacaaaaca gaccaagaat acagagtgtc 268800tgctcccata gagctgacat tctaaggaga gagacgggaa ctttttacaa gtaaaagcat 268860caacaggccg ggcatggtgg ctcacgcctg taatctcagc actttgggag accaaggcag 268920gtggatcact tgaggtcagg agttcgagac cagcctggcc aacatggtga aactctgtcc 268980ctactaaaaa tacaaaaatt agccgggcac ggtggcaggt gcctgtaatc ccagctactc 269040aggaggctga ggcaagagaa tcacttgatt ctcaggaggc gagaggttgt agtaagccaa 269100gattgtgcca ctgccctcca gcctgggcga cagagtgaaa ctctgtctca aaaagaaaag 269160gaagaaaaag aaagaaagaa acgtgaagtg cttggcacag aacctgccag gaaaccagga 269220gtttgaaaat ggtggttgtt aactattact gctgttgtta ttgttattgt gaatgggtgt 269280gtagttttgt tagccagccc tgagttacag tcaatttgag ggaaagatag ggggtgggtg 269340tttgggtcct tctgggacaa ttaactccca acctggagta gggagaggca tgtcctggca 269400ggcaaggagg tctcagttgc ccctttctgc ctcccaggta agcccactag ttctgaggcc 269460agggcttggc caggctgaga caggaaatgc cagatgcttg ggcgggcagg tccctggggt 269520ttagggggca gagggcatgc ggcagtacta accagtgctg tctcagctgc tgcccccaag 269580tggctggggt gatgtgggtt tgccctgtgt gcaatggata atgactgtgt ttcttgtctt 269640gtctcttttc atgcctgctc ttaaaactgt atattggcgc aacgccgtct gaaaaactca 269700tccaatcaaa atgcactatg aaattcattt gttcatccat gacatggtct gtgtgttcat 269760acaccaatga cttatctccc aacccaccgc caccaccacc cccactcccc gcccgggaac 269820cgaaacccat tggttttttg gcactggtta caaatcaacc taaaaaatgc tgaacacgcc 269880tccccaactg cccccgcccg cccgctcccc ctcatcttca acatctgcat ctagaatccg 269940gttggtctta cttctttctg aagtctaaat gccttacatt aactgtgaac gcatctcctc 270000gcgtcggcat tgcatgccac accctgcctc tccaacgtgg gatgcctgac gctctcctca 270060accctccgct ctcctctgtc tgtctgtcct cccgccccca gcccctgtgc ctcccacttc 270120ctgtagactc tgtctctctg tttttatcgg gttctgaatg ggggttttct gtttggggtg 270180gtttgcgtct tttgcagaga aagggatggg ttttcccagc gcagcacctc tctcttgccc 270240catcccgcac acacatcccc tacactcaga gacaatagag gcaaatccac tcccagccac 270300ctctcaccac tcctgtcccc cattcagctc catggacccc aggccccagg aaagctgcca 270360actgtctcct cgcccctcca gctctctcca tcctgctgtc cccaatcctc catctcaagc 270420ccacaagatc tttggccttg accagcagag acttgactct ccaagtctga taaaggagac 270480ctgaaggcca ggcagtgtgc cggcaaagac tctcaggcag aggaactcag aagtgccaga 270540cttggatctg gtagcttcat gtggggctgg cccactgagg ccctctcctg gagccttgaa 270600ctgtacgtgc acacgcagtc acacagtcac tgcacacaga cactgcacac acagtcactg 270660tgcacacact cagtcactgc gcacacactg tgcacacagt cactgcacac agacgctgca 270720cgcagtcact gcagtcactg cacacagtca ctatgcacac acagtcactg cacacagaca 270780ctgcacacac agtcactatc cacacacaca gtcactgcgc agacactgca cacacactgc 270840acacacacaa tcactgcgca cacacagtca ctgcacgcag aaactggaca cacagtcact 270900atgcacacac tgcacacacc actatgcaca cacactgtgc acagtcacta tgtacacaca 270960ctggcactgc atgtagtcac tatggacaca cactgcacag tcactgtgca cacatacact 271020gcacacactg tcactatgca aacacagtca ctgcacacag

tcactatgca cacacactgc 271080acacacagtc actgcacaca gagccactat gcatgcacac acagtctgca ttcacacatt 271140gaacacacag tcgctataca cacacagtca ctgcacacac agtctatgca cccacacact 271200gaacacacag tcactgcatg tacagacact gcacatagtc atgacctctt ctctttttct 271260cactcattct ccaattctct ctctctctcg ctcttttttt tttttttttt tagacagagt 271320ctcgctctgt cacccaggct ggcgtgcagt ggcacaatgt cagctaactg caacctctgc 271380ctccccgttt caagcaatta tgatgcctca gcctcctgag tacctgggat tacaagcatg 271440taccaccacg ccaggccact tcttgtattt ttagtagaga cagggtttca ccatgttggc 271500caggctggtc tcgaactcct gacctcaagt gatgcacccg cctcagcctc ccaaagtgtt 271560gggattacag gtgtgagcca ctacacctgg cctctaatcc tcattcactg ttcctgtctc 271620tgtgtctctc acatacagtc atgcatgcat gcacgcatgc acacacacac acactggccc 271680tctctgctac atctacccac cctgtacccc cactccagta catactgcac acatctctct 271740ccctccccca cttctcagcc ccttgcacac cccttgttct gttaaatctc aactgcctct 271800gcccctctcc tacccaccaa tgaggccctt agagggacgc cccaatggca tctttgccct 271860ggaatcatcc cttccctgct ggcaatacac atgcattcac ccaccaaaca tttaatgagc 271920ccctatttgg tgccacagat ggaattatgg gcagaagcag acaccattac tgtcccctct 271980taccacatac agtcaggtgg gggaggcagg catcggtcaa ataacccctt gactccactt 272040aaaattatac ctgcactgcg agctgaagga tgagcagcat taacaaggca gagagagatg 272100cacagagcat tccaggccca ggacagcaca tgcaaaggcc ctgtggtggg acggaacctg 272160tgaggggtca ggatctgcaa gcgagggaat gtggctgatg caaagacagc cgagaaaggc 272220tggcctggag acagccgaag aaggcagaag gggacaggac ccggggctgg ggagggcggg 272280gctatattgt ggaatatggg ctttctccta agcaccagga agggcctggg aggataggaa 272340gcaggggagg cgcgactggt catgtgacta gacaagctcg ctctggttgc agggcaggga 272400acagcttgac aggaggctgg gctggaggtg ggcaccagga atcgcagcaa gagatgacag 272460tggaggagag agaacagtgg gagggttgtc ctctgcagga cccagggaaa gatcaggtct 272520gaactgagat gaggtgcctg ggagcagtcg ggtctggctt aaaactggga gataggctga 272580gcacggtgac tcaagcctct aatcccagca ctttgggagg ctgaggcagg aagatcacct 272640gaggtcagga gttcgagacc agcctgacca acatggtgaa accccatctc tcctaaaaaa 272700tacaaaaatt agccaggcgt ggtggcaggt gcctgtaatc ccagatcctc aggaggccga 272760gacaggagaa tcacttaaac ctgggaggtg gaggttgcag tgagccgagg tcgtgccatt 272820gcactccagc ctgggcaaca gagtgagact ctcttaaaaa aaaaatactg ggtgatagag 272880gtgagcgagt gcaaggaaag gaccaggttg ggggaagaga ataggtgtgg gcatagcaag 272940tttgaggtgc ctttaggaca tcccgaaata agtcagatag gcaggtgttg tgggggctgc 273000agcttggagc tgaggtctac aagtagtagg acttttctgg agcccttagg tgggtggtct 273060ccatatcctt ctgagcactt gaggaacatc tgagcacagc actggaaaag aaaagaccac 273120aaggacgctg tcctcatgtc ttccaggggc tgtgtcccac ccccatcaca ttctagccag 273180gaagttcagg ggaggtgttg aagagaggaa gctgcacctc ccaagccatg gattgaaatg 273240tggaaggcag gaagagggaa cttgtcagaa gttctggggg cagtggaaag aattggtact 273300gatgcaggaa gagatggagg gtggatgagg gcagactagt acccttcccc cactgcccca 273360aacccttccc gtctccaccc ctacctgcct catgtgtctc ctcccccact tggctccaag 273420aagggaagca tgttttctgc acgcatctcc ctgccagatc cctggctttt ttgcatggtt 273480gcaagcttcc cctgctctcc tccaaacccc cctcctgagg ctgcttccag ggtccgcctg 273540ccttcgcatg cctggccgag tccacatgtt atgatccgcc ccatgaaagg gatggcttgt 273600actctggggt tgaacgggag ggggctgggg atacctgagc catcggcccc atccccaggt 273660ggagctgggt ggccaggcag ggatgggggt cagggcagca gggcacagag agtgactctg 273720ttagccaagc tgggtttggg gcttgttcga ggcactggag acattctcac agcacttgag 273780cccagtgtgg tcagggtagg atcccccagc ccccttcccc atcctagagg cctaaggacg 273840cactgatgtg tcccagagag catcctagac attgccatca aacccagagg cctcagaaat 273900tccttgaact ccagtccttg cctctcagct cccaggccaa agccagcaca agacacagat 273960ctggcagcca gaaagccctc tggaagccac caagtaggat gcccatgtca cccaaactag 274020gacacttttg aaacaggagg gaggctgtga ctgtatggtc accctgtgcc atttgggggg 274080tgaaggttag accaagttaa atcttgctac gtggcctgta gcaaatccta caaatcccat 274140agaacaagtc tgattaagcc ccttccctta gtgtggagag accctctact cctcctgcct 274200tcaccctgct gggtactggc cagcgaagga gggtttccat gtctgcctga ggctggggtc 274260tcaaactcaa atgcctctgg gggccaggca gacaccagtc aaccaggaaa gcaagtgcca 274320tttctaaaac gtgaggaccc tggaaaactg gagatcatgt ggcctgcttc cagggagcaa 274380tcgcagcagg cctggggttg ccagaaagcc agattggtgg gcaaaatctc ttgattttta 274440aacaatggca ataattttta attaaaaaca aggacaaatg aaaaaacact gctcgggccc 274500aacaaaacag ttttattagc tagatttggc ccactcgtga cttcgagagt cccacccccc 274560ccaccaaggt cccttgaagc cccacaatgg ccacttaact ctagctggtc tcctccctga 274620ctctccaact ctctggcccc ctggttcttc tagcttgggt gggaggaggc agaggcagtg 274680actagacagg gggtttttga gcagaggcag tggccaccca gggaggtcct gggggcaggg 274740atggccccac ctcccggccc ccagcacccg ccccttggtg ggcccgggct gatttctgag 274800ctcacccacc catgggagct gagtgcttcc tgcttcctgc aggcctggtc ccgtgctact 274860ccacccagcc ccagaagctg agaagccatc cctgagaggg gggaaaaggg ccccaaatgc 274920atcttctccg actcagcggg cagcgaggac tcaccctgca gccgaacagt cccagctccc 274980tcccgtcctc cccattcccg ctcgccaagg gggtaagaaa agatgctctt ccgcttctcc 275040caattggctc gagccgctgc tcctcttggc cgtggggtga ggtcagggcg ggcaggagcg 275100ggtgggcagc tcggcagggc agggcagggc agggtgcccg gtgagtcccg tgacagatgc 275160atttctggcc cggagcgtaa catgccctcg gaacccgcac atgtccacca ggcctgactg 275220tgctggcgac ctccaccccc acccccgccc tggtgtttgt gcatcgtaca cgtatgatag 275280attccgcaac ttgaccggct tgtgtccttt cgtctcagtg catttggttg ttgggagaaa 275340caaaaaccat ctcgattttt ttcctgattg gatgattcgg atatattttc tttttcttgt 275400tcttttgtta tttcttcccc atccccgttc ctttttcctc ctttcttttt cttttctttt 275460ccccattgtg ggtggggctg gcagggaggg cttatgcttt tgagttgatg ccttttcctc 275520cctcccaccc tctctctccc aacattattc ctttttcgag tttttcctct gcatcattgc 275580attaatagtg ctttctctct ccctccttat ttggggtctg gcttgctttt ttcctgttgg 275640ttggcttcat gtaggggcct ctgtgagtgg tgacagctct gagccttttg gggtgggtgg 275700atggtcaccc ctcttcctcc atctccccag aataacttca tcaacctgag ctttctccgc 275760ctcttccgag ctgcccggct catcaaactt ctccgtcagg gttacaccat ccgcattctt 275820ctctggacct ttgtgcagtc cttcaaggtg agtcctcgtc cctgctgctg gcccagggct 275880gagaagacag gtgaccctca tgctctggct gaatgtagaa gtcagattgg aagtgcctct 275940gtgatgtagt cgtgcagaga atctgttatc tccaaggctg ttgtcaaact tcctgtccct 276000ggtgtgtctt cagagctgta agggcctcat cctagagccc ccagagatgc ccaccagccc 276060tggaaggact ctggcacgtg gcatatggcc acccaaccca gtggggcaga gcactgggac 276120aagggaggaa gacagtgcgg ctgagggacc cccagcactc ttcttcattg ccttttttcc 276180caccaggccc tgccttatgt ctgtctgctg atcgccatgc tcttcttcat ctatgccatc 276240attgggatgc aggtgagtgt cgtgtcccta aggttcccag agcctcccaa ggagggcagc 276300cacccttaga aaggggtggg tcagaggagc ctggttcaca gaagcagcca tggaggttga 276360gctgggtttc ccagaagcca ctggaggaat ggcagcccct ggtcgtcacc ctccaattcc 276420acaggtgttt ggtaacattg gcatcgacgt ggaggacgag gacagtgatg aagatgagtt 276480ccaaatcact gagcacaata acttccggac cttcttccag gccctcatgc ttctcttccg 276540gtgagaaggg gacctgctct gataattctg tttccgtggg gtggggtgcc tgccttcatc 276600cttctgttcc catagaggat gtaccctcct cttccaatgc aagacgtgcc ctcctccttc 276660tcttctggca ggggcgcgcc ctcacccttc ttttccggta gggggcgtgc ccttctcttc 276720cggtagggga cgtgccggcc ttctcttccg atagggggcg tgccctcctc ctccttttct 276780ggtgtggggg tggccagatg tgctcttatc cttcttttcc cgtgaggctg gaaatgggtg 276840tcgtgggggg cccaggaatc ctagcagggc agaagcagag ggccctggga catagtcatc 276900aaggtcattt tccaggcatt atctctgaat cttcctgacc accctgtgag gaagggattc 276960ttggcagccc tatccgacaa ataagaaaac aggcttacag accgtgaggc ttgattcttt 277020ggttcatcat cttggctgca cacaaaagtt ccttcactcg ttcagtgtag gttttttggg 277080ggggcttttt tttttttttt tttttttttt ggagatggag tctcgctctg ttccccaggc 277140tggagtacag tggcgcgatc tcggctcact gcaagctccg cctcccgggt tcacgccatt 277200ctcctgcctc agcctcccga gtagctggga ctacaggcgc ccgccaccac gcccagataa 277260tttttttgta tttttagtag agtcggggtt tcaccatgtt agccaggatg gtctcgatct 277320cctgacctcg tgatccgccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc 277380accgtgccca gccctttttt tttttttttt ttagatggag tctctctctg ttgcccaggc 277440tggagtgcag tggcgccatc tcggctcact gcaagctcct cttgtggagg tgtattgagc 277500acctacagca tgccaggcag ggctgaaaaa cgaggatgca ccaggaaata gagaaaagag 277560acattttaag cactttggaa gctaacatcc ccatggggaa gacgaataat caggaaacaa 277620attatagagg atgctggaaa aagataaaat tcaagaataa aggggaatag ggccaggtgc 277680agtgactcgt gcctgtaatc ctagcatttt gggaggccga ggtgggagga tcgctttagc 277740ccaggagttt gagaccagcc tgggcaacat agtgagaccc cgtctctaca aaaaaattgt 277800ttttaattaa ctgggcatag tgccacacac ctgtagtccc agctacttgg gaggctgagg 277860caggaggatt gctcgagccc aggagttcca ggctacagta agctatgatt gtgccactgc 277920actccagcct cggcaacaga gcgagactct gtctctaaaa agaaaaatat atttttttaa 277980tttttaaaaa aagttacaga ggtagatagt ggtgatagtt gcataataat gtgagcttac 278040ttaatgctac tgaattgtac acttcaaaat ggttaaattg ataaacttca tgctgtgtgt 278100attttgccac agtaaaaaat aataatgttt ttaatctaac aacaaaaaaa gaatagaggg 278160ccggcaggtt atgcctctct gaaagtgtga catttgagag aaattggcaa gggagggagt 278220cagtgggtat atggggaagg gcaggccaag ccgaggggac tgcctgtgta aaggccctga 278280ggcaggagta tggctggcat gtttgaggac tgtgaggagc ccagcatacc tagaacagag 278340tgatctaggg agaatatagt atgagatgac tgtcaccttc atggagggga gctttttttt 278400ttttttaatc tgagacagag tttcggtctt gttgcccagg ctggagtgca gtggtgcgat 278460ctcggctcgg cgcaacttct gcctcccagg ttcaagcagt tctcctgcct cagcctcccg 278520agtagctgag attataggtg cccgtcacca cgcccagcta atttttgtat ttttagtaga 278580gacggggttt tgccatgttg gtcaggccgt tctcaaactc ctgacctcag gtgatccacc 278640cgcctcagcc acccaaagtg ctgggattac aggcatgagc cactgcaccc ggcctgaagg 278700gagctttttt ttttttttgc ttttttttga gacagaatct ccctctttgt cacccaggct 278760ggagtgcagt ggcgcgatct cagctcactg caacctccgc ctcctgggtt caagcgattt 278820tcctgcctca gcctcccaag tagctgagac tacaggtgag cgccaccaca ccgagcaaat 278880ttttggtatt tttagtagag atagggtttc accatgttag ccaggatggt ctcaatctcc 278940tgacctcgtg atccacccac ctcagcctcc caaagtgctg ggattacagg tgtgagccac 279000cgcgcccagc caagagggga gcttttaaag cataacagtg accagcctga gcaatgcagt 279060gaaaccccat ctctacaaaa aaaaatagtt taaaaattag ccaggagtgg tggcgtgtgc 279120ctgtagtccc cagctactca ggaggccgag gcgggaggat cacctgagcc tgggaagttg 279180aggctgcagt gagcagtgat tgtgccacta cactccaacc tgggtaacag agcaagaccc 279240tgtcaaaaaa aaaaaagaga gagagagaga aaagaaagga aaagaaagag agagagaagg 279300aaaagaaaag aaaaaaacat atcagtgtcc tcaaatccca ccctagacca actgaatcca 279360agtctgctgg ggtggggcac gggcattggt attttttcaa agctctctgt ggacttcagt 279420gcacagccaa gaatgtgaat tcccttctct cagctcccag taaaaggagg tggtccacct 279480ggggcttgcc tggccagctc cagagcccaa gtgctcaacg tgtgtgctcc acctcctggg 279540gaggcgttgg tacccagtca gggctgggtg tccgagtctc tgatttctcc ctgtcctcag 279600gagtgccacc ggggaagctt ggcacaacat catgctttcc tgcctcagcg ggaaaccgtg 279660tgataagaac tctggcatcc tgactcgaga gtgtggcaat gaatttgctt atttttactt 279720tgtttccttc atcttcctct gctcgtttct ggtgagtctg tggacactgt gagggccgtc 279780tgggctccct aagcctggct tcctttcagg ggagtgggtt tctgtggaat gtggctgtgt 279840cgaaggcttg ttccctccaa ggcttctctg aaccagcctg ggatcaggtg accctgagcg 279900tctcaaactc agcactgttg acatttgggg gtggctgatt ctttggggtg gggccatcat 279960gtgcactgca gtgtatggca gcatccctgt cctcccccca ccagatgctg gcagcacacg 280020ccacccgttc ctcctgttgt gacaaccaaa aatgtctccg gacattgcca ggtgccccca 280080gggggtgggg gtggggttgg gagtgggggc cagaattccc ccatttgaga ctcaatgaaa 280140tatttcagct gggcgtagtg gccgatgcct gtaatcccaa cacttcggga ggctgaggtg 280200ggagggtcac ttgagcccag gaatacaaga ccagcctgga cagcatggtg tgaaacccat 280260ctctttaaaa aaaaaaaaaa aaattgaatt agctgcacac gtggtgctgt gcacctgcag 280320tcccagctac tcaggaggct gaggtgggag gatcacttga gccttggagg tcgaggctgc 280380agtgagccat gatcacacca ctgcacccca gccagggcga cagaatgaga tcctgtctca 280440aaaacaaaca aaaacaaaca aaaaaaaaaa aaacattgcg agggaagaaa tacctcactt 280500tggccttgtt gggggcagat gtgggaggat ttggggtcac agtggttctc ttggtgttgg 280560tccctgtttc agaagcctcc cctccctctc actgactctg tttctttcca tcattcttgg 280620tctttgtctc tctctctctt tttttttttt ctttgaaatg gagtctcact ctgttgccca 280680ggctaaagtg cagtggcgag acctcagctc actgcagcct ccacctccca ggttcaaccg 280740attcttcagc ttcaacctcc caagtagctg ggattacagg tgcacatgcc accacaccca 280800gctaattttt gtatttttag tagagacagt gtttcaccat gttgaccagg ctggtctcaa 280860actcctgacc tcaagtgatc tgtccacctc ggcctcccaa agtgctggga ttacaggcgt 280920gatccaccgt gcccggccag tctttgtctc tttgtatctc tctctctcca tctctctctg 280980tttctctctt cctcttcccc atctctccac ttgatctctc tctcactgga cctccttgtg 281040tgagtgagca tcacctctcc attccccagt ctctttctgt ctctgtctca tttcctttcc 281100ccatcttctc tctatccctc tctccatctg ggcctctgtg tacatgtctt tgggtctgtc 281160tgtccgtctg tctgtctgta tccttctcac tcactcattc attccctcgg tctctgcccc 281220cattctctct tggtccccgg ggtccccaca gatgctgaat ctctttgtcg ccgtcatcat 281280ggacaacttt gagtacctca cccgagactc ctccatcctg ggcccccacc acctggatga 281340gtacgtgcgt gtctgggccg agtatgaccc cgcagcttgg taagaagtca ccccgaatcc 281400tccagccaca atactcacct ctccctggaa ctggaacacg ggctaggtca ggccccagac 281460tctggagcac tgaactcctg gggtcctagc aggggtctca caggttcagt caggagagaa 281520gatataagaa tcatcaccct tgcatacccc agattaaaca cgtagggtgc caaccctgcc 281580caaaccctgg actttctggg aaatgaggga gggcgtcaac catgagatgt cctgaagagc 281640cctctcctcc tacgagtctc tcctgtctct cactgtgaag tctccagatg gtgaggatgc 281700attagccagg ctccagggag aaaaccaaca gcatcccagc ctcagttctc ttgagagtgt 281760ggggaggagg gctggcctac ccttggcaga caggattggc agcaacatca gagtagcaga 281820actcagctcc cactgggacc cgtgaacctg ggagtgagag gacatacagg ccaggggagg 281880acgcagagcc tcaggggccc atgcatcttt gtggccacaa agggagtggg cgctcccatc 281940tgggtagaca ccagaggggt ccctctccac tgacgggcaa tggtttcaga gggtgggttc 282000caccttgtgc acgtgtattg agtgcccacc caacaccaag ccttgaagga cactcagagg 282060ctttatctga atacctggaa cccaccagcc actaactgag gatttagttc aggctggtct 282120tggggcctga agaagcatta ctggggggcc ctcagcagcc taagccccat cttcctctgg 282180cctcagcacc agagaggagg ccgtcacgag gaaggtgggc aggaggtggt cttggctatt 282240cccatagcct caaacaagta ctccatgaga ccgagaggct ggggagagcc gtgggtctgg 282300ggctgggctt tggctggttc ctaactcttc ctcttttgat tttaggtcac agcaattgga 282360tgctgtcccc aaggcctcta ttccacaagc ccccccccac ccctgtagcc catgtagact 282420gtggaggagg cagatgcaga gagagcccca ggggaggtgc cctgcagtcc cgaactcgac 282480tgacatccta cacccctggg tctccccagt gtctgggaat gtactgggga ccttcacttg 282540tccccagtct ctcccactcc ttcaagccag ggacacccca gcctcgggca tcatgacctc 282600gctgtgtgcc cagggagccc gtgtgaaccc attgcctgca ctaaccccct ttcttctcct 282660ttcagcggtc ggattcatta taaggatatg tacagtttat tacgagtaat atctccccct 282720ctcggcttag gcaagaaatg tcctcatagg gttgcttgca aggtttgact tccactaaaa 282780cctgctagca tccatggaat gagtgtggct tggggttctt caatatatat atttcatata 282840tatatatata tatatctctc tctctctcta aaaaaacaga gccatctctc tttcttgcat 282900taaactagaa aactctctta gccaacagaa tgcagtcatg tagactcgat aaagcatgga 282960acatatttcc tccttccctt cagccttcag ccatctttgc ttgctcttag ctgaagctgc 283020ccatcctggg gtctccacgg caccccaaat cagatacatc ccctggggga ttgtaacttt 283080gcatttctcc cccaaccatc acctccactc tctccccctc cacccctcac ctcccaaagc 283140ccctagccct cctcccctcc ctggcactgg cccctgctcc ccacctaggc cccctcagag 283200accagcctca gccaaaccag agaacgtgac ccaactgtag aaataacagt gatggccggg 283260cgcagtggct catgcctgta atcccagcac tttgggaggc caaagcagga ggatcgcttg 283320agcccaggag tttgagacca gcctgggcaa catagcaaga acccccttct ctataaaaaa 283380ttagccaggc attgtggcgc atgcctgtag tcccagctac ttgggaggct gaggcagaag 283440gattgcttga gcccaggagg tggaggctgc agtgagctat gatcacacca ctgcactcca 283500acccaggcga cagagagaga ccctgtctct ttaaaaaaaa aaaaaaaaaa aaaaaaaggc 283560aatgaacaaa agcatggctc tacgtcttcc aaagtgagaa ttctccctcc cctccgcatc 283620cctccagaac tgtagctcag agcccacgct gaatctgact tttctctttt ctctctctct 283680ccctgctccc gagcagtgaa gtaatctttt tttactgacc ttttcttcca ttttttttcc 283740tcctcttttc cattgatttg aaatatctat tttatcattc tctgcatctt tctctctcta 283800ttttttcggc tcgtgtggat ttcttttttc tttcttctgt ttctccccac ctctcttcct 283860ttggttctct gttcccattc ccgttttgtt tttttgtttt tgtttttgtt tttttcattt 283920tcggtgctgc caggggccgc atgccttacc tggacatgta tcagatgctg agacacatgt 283980ctccgcccct gggtctgggg aagaagtgtc cggccagagt ggcttacaag gtagactacc 284040cttgccgacc accgacgtcc aggcactggg tttttttttc ttcttcttct tctttttttt 284100tagtgctgac cagaaacacc cggccgactc tctttttcca acgtttctct tcttttttgt 284160ttttgattct tttttttctt ttctcgagtc aactgatcat gaccatccct tgattctaag 284220cagcacactg tgtccgtcct ttctgatgag tgtcttcgtg ttttgagact ccattatggc 284280cgacatgccg gggggagggg gaggggagcg cccaggtccc cttgcacctg gtctcccagg 284340taccaaattg gaaacaaaca cgcttcttca gggagtcaaa acccatgctt cccacttctg 284400cccacccaga gcggccccca tgcccaggct ggggcaggcg ccttgcagag aggggcttta 284460gcccccgaaa gcaggcgagg tcccgggtcc ccgcccctgc cacgcacacc tgaagctgat 284520ctctgaccta gggccttggg gattcgagac cttccaagga gcaccaagaa cctctcttcc 284580cctcccttcc ttcccctgga gtttcgtccc cagcccccgt ccctaatccc cccaagacac 284640cccaacatgc ctctccattg ttccagagtg ggcaggcggc cgcagctgga cccctggacg 284700gtggcacact gatgcaggcc atgcacgctg ccttggcggg gcctggggcg ggcaggcacc 284760atggccgacg gggggtggtg catgctggct gagagagcga gcgtcctgcc gccaagcggc 284820tggcccgggc cacccctcca gatccctgtc ctggaatctc ccttggtgcc caaggacaga 284880tgctctgttc cctccattca tccacaagaa gttcagggat gacctttaaa gattctcccc 284940acccaaaaag tattacccca tcatcctatt ctcccatcca ccttgatctt ccctgcgtcc 285000ctatccatca atgctatttg tacctgcccc gtgttgccac ctcattcctt tccttcctct 285060gtgcacccct cctcacctaa cctatatgtc tcccctcctt ctcaatcaaa gccggggaca 285120aggttgtccc accagcatct cagacaatga gcctctcctg gcacctgtcg ctctgtgccc 285180ctccctgccg cccccccccc cccccccggt tttcctcaag tcgcttctct cagtctctgc 285240ttagatgaat gtgtgcgcat gtgcaagaga gggagggcga gcccttcctc tcctggtctt 285300tgtgcaggac caccatgggt ccataagaca actttgtgca aatttgaaaa aggcaccctt 285360tccacagaac atgcctgttg gaaaattgtt gcaatctacc aatgtggtga gaacaagaca 285420ctttttttct atcacctggg aagctgttat atttaatata caaatcgggg gctgggcgtg 285480gtggctcatg cctgtaatcc tagtgctttg ggaggctgag acgggaggat cacttgagcc 285540cagttcgaga ctagcctggg caacatagcg agaccccatc tctacaaaaa gaaaaaatat 285600tttaattaat aaataagtac ataaatctat catttccaag atgggagccc tttgtgcggt 285660gtacaacctg cacaactgtg cacagtggcc cagtctatgt gtgtttctct atttcccacc 285720tccttcccca ccctaccccc agtgtcccct ccagtgtcct gctctggatt taccataccc 285780ctccccatct tcaactctgt gtttcctgcc cacttgtgtc tgaatcccca cccaagttgc 285840cctcaccccc cttctctgtg ccacttcagc ctgggctggt gcacaccagc ccagcatcct 285900ctcccatgcc accaagcatg gtggacagag cccctgcctg ggacatgggg aatcttttct 285960tccctgggct ggaagggagt gcccctcacc ccttccccct gccattgcac agagagccaa 286020gatctggaca tgcccctgag atacacttcc cacggagcta tgaatgagtc tcgagattcc 286080gtctgcatgc gcccctgtct gtgctgttct gtgtcacagc

ctcgctgcat gcctgcgagg 286140ggcctgcccc gtcagtgggg ggctgcctgc ctgctgcttc tcagaggaat gatgtggtct 286200gtgcccatct gctctgtcct ggtctgggcc aagccaggga ttgggtgtgg ggagccagtg 286260gcacccccca ccagcggctg tggtcctggc cccctcagcc ttggctgttg catgcactgc 286320tcaaatccag cttgtgctct ttttctttgg ggtcagactg aaacggggcc atccagaaga 286380actctggggc agggcggggg tggggcaagg gttgaggcaa accctggaaa tgccagctct 286440caggtcaagc aggtggggga aaaaaggaga gggcagggga ccagaagtac aagagagcct 286500tttgtgccct ccctgcgggc caccaagaga aactgagtac tgggacaggt aacctaagta 286560agagacacct cagccgccac agctttcaga gttcttcctg ggactccctg ggtaggggcg 286620ggcgcggctc acgggagacc caggagggat gcctgggaat gactgcgctt gccttgggtt 286680ttctgtagcg gcttctgcgg atggacctgc ccgtcgcaga tgacaacacc gtccacttca 286740attccaccct catggctctg atccgcacag ccctggacat caagattgcc aagggtaagg 286800aagggacagg ggcgggcaca gacaggcgtg acagggtgga accggggatc tccctcccta 286860ccccaaacta gaggatctgc tgtcaccacc cggatcttca ttcactcttc cattcattcg 286920ttccacaggg ttttttgggg tttggggttt tggtgttttt tttttttttt ttttgagaca 286980gagtcttgct ctgttgccca ggcagcagtg cggtgacatg atcgcaagtc actgcagcct 287040tgacctccca ggctcaagtg atccttccac ctcagcctcc ccagtagctg ggactacagg 287100cacacaccac catactcggc taattttttt ttttttggtg tgacaatttc cctctgtcac 287160ccaggctgaa gtgcagtggt gtgatcttgg ctcattgcta cctccgcctc ccgggttcaa 287220gcgattctcc tgcctcagcc tcccaagtag ctgggattat aggtacccac cagcacaccc 287280ggctaatttt ttatattttg ggtagagatg gggtttcacc atgttggcca ggctggtctc 287340gaactcctga cctctggtct caaactcctg acctcaagtg atccacctgc ctcgacctct 287400caaagtgctg gattacaggc gtgagccacc atgcccaacc taatttttta tattttttat 287460agagatgggg tttcatcagg ttgcccaggc tggtctcaaa ctcctgggct caagcagtcc 287520tcccaccttg gtctcccaaa atgctggtat tacaggcatg agccaccaca cccggcccat 287580ttggcagata tttagtgcac tccttcaatg tgccagagac ccgtccaagc aggggaggac 287640ccagcagctt acactttaga tggatgggga ggccgccact gaggaggtaa ggcagtgtct 287700catggatccc tggggggaag gtgctccagg cagaaggact ggcaaaggcc ctgacagagg 287760ggtgaacaca ggacacccgg ggcattgagc tgactcacct tctgagtgag ggcacgccac 287820gcaggttcag agcagaggag gaacctgacc caactcacat ttgaacaggt tccctccggc 287880cactgagggg atgggagacc gaaaggaggc cagtgtgggg gctgctgata tcatctgggt 287940ggagacaggg cggcagctta gatctagggg taggctcgac gtggtggctc acgcctgtaa 288000tctcagcact ttgggaggcc aaggtgggtg gattacttga ggtcaggatg accagcctgg 288060ccaatgtggt gaaacccccg tctctactaa aaatacaaaa tttagccaga cgtggtggtg 288120ggtactgtag tcccagctac tagggaggat gaggcagaag aatcgcttga acctgggagg 288180cggaggttgc agtgagccga gatcacgcca ctgcactaca gcctgggtga cagagcaaga 288240ctctgtctca aaaattaaat taaattaaat taactggaca tggtggcata tgcctgtggt 288300cccagctact caggaggcag agatgagagt attgcttgaa gccaggagtt tgaggctgca 288360gtgagtcatg atcgcaccac tgcactccag cctgggcgac agaacgagat cctagctcaa 288420aacaacagaa agaaaaagaa aaaaacattt tttttaaagc tgagaagggg ctgggcgcag 288480tggcttacgc ctgtaatccc agcactttgg gaggccaagg tgggtggatc acgaggtcag 288540gagttcaaga ccagcctggc caacatggtg aaaccccatc tctaccaaaa atacaaaaag 288600tagccgggtg tcatggtggg cgcctgtaac cccagctact ccggaggctg aggcaggaga 288660atcacttgaa cctgggagac agaggttgca gtgagccaag atcgcgccac tgaactccag 288720cctggatgac agagcaagac gctgtctcaa aaaaaaaaaa agctgaggcc gggcacgctg 288780gctcacgcct gtaatagcag cactttggga ggccgaggcg ggcagatcat gaggtcaaga 288840aatcgagacc atcctgggta acacggtgaa accccttctc tactaaaaat acaaaaaatt 288900agctgggtgt ggtggcacgc acctgtagtc cctgctactc agaaggctga ggcaggagaa 288960ttgcttgaac ccgagaggca gaggttgcag cgagccgagc ttgtgccact gcactccagc 289020ctgggtgaca gagtgagact tcatctgaaa aaaaaaaaaa aaaaaagccg agaaggctgg 289080acatggtggc tcacacctgt aatctcagca ttttgttgag gccaggcaca gtggttcacg 289140cctgtaatct gagcacgctg ggaggccgag gtgggtggat catttgaggt caggagttcg 289200agatcagcct ggccaacgtg gcaaaaccct gtctctacta aaaatacaaa aattagccgg 289260gtgtcgtggc gtgtgcctgt aatcccagca ctttgggagg ctgaagcggg tggatcactt 289320gaggtcagga gttcaagacc agcctggtca acatggcaaa accctgtctc tactaaaaat 289380acaaaaatta gccaggtgtg gtggcgggta cctgtaatcc cagttactag ggaggctgag 289440gcagaagaat cacttgaacc cgggaggcag agattgcagt gagccgagat cacatcactg 289500cactttagcc tgggcgacag agcaagactc catctcaaaa ataaaaataa aaataaaaaa 289560taccgagaaa ttcccccaaa gacctagctc agggctcact ctccatcatt agggggaaag 289620aagaagagga ggccagggag gcgggcagag accagggcag tgtgggctcc tggaggcagc 289680ttctatgttt aaaagggcgg cttcaggagg aaggggacca accgtgtcag gcactgccca 289740gagaccaagg atgacaagga tcacaagtga ctggtcatca tggtcacttt gaccagtgca 289800gctttggcgg aggggtcagg ggtcccctgt ctggagtgca tttcggaggc ccgaaagggg 289860atgtgatgtg atttggcagc tgattaagga cagcagggca gagagacagg cgcacaattg 289920ccagaagaaa cggggacctg aggctcacgc ctgtaatccc agcactttgg gaggctgagg 289980aaggtggatc acttgaggcc aggaatttga gaccagcctg gccaacatgg cgaaacccca 290040tctccactaa aaatacaaaa attagccagg catggtggtg cacacctata atcccaacaa 290100cttgggaagc tgagcacaag aattacttga acctgggagg cagaggttgc agtgagccga 290160gatcaaacca ttgcactcca gcctggggga cacagcaaga ctctgtctca aaaaaaaaaa 290220aaaaaagaaa gaaagaaaga aaagaaaaaa caaatgggac cagaaaaaag gagtgggtgg 290280gagaggagca ggtggatagt cccacacatg ggaaggtgct gagcccagct gaaaccacta 290340gtaagtcagg aggagggaag actgagcctc gagacatatg tgccttccag ggtcttgagg 290400gaaagaaggg aggaagagcc aaggccacgt ggcaagactc aaggaggaag tggcagggaa 290460ggtgggggac tggaggggtg gaggacagat attgttaatg ccaggaacaa agtgaaggta 290520aagagagcac aaggaagttg ggagcagtgg ctcacacctg taatcccagc actttgggaa 290580gccaaggcag gaggatcact tgaggccagg agttcaagat cagcctggcc aacacagaga 290640gaccccatct ctacagaaaa ttttaaaatt agccaggtgt ggtgatgtgc acctgtagtc 290700ccaactactt gggaggctgg agtgggagga tcactgggga ctgggatgtc aaggctgcag 290760tgagctatat gatgaccaca gacatagcag cttaagacac acctatttgt cagctcacag 290820tcctgtaggt cagaagtcca aaaagctgga ctgggctgtc tgctgagggt ctcacgaggc 290880tgaaatcaag gtgtcagcca agctgggctc ctctctggag gatctggggg agaatctact 290940tccaggttca ttcaggtgtt ggcagaattg aagtccttgt ggctgtagga ctgaggtctt 291000gttttatcac tggcttttta gctttttgct cctggaagtg catgtaatcc tccatgtgct 291060ctcattctct ctgacttccc catctgccac ccagcagaga caatactgtg cttttcaagg 291120gctcacctga ttggggcagg cctaccctga tcatctctgt attttgaggt cagctgactt 291180gatatttttt ttttttcttg agacagaatt tcactcttgt tgccaaggct ggagtataat 291240agtgtgatct cagttcactg caatctccgc ctcccaggtt caagcaattc tcctgcctca 291300gcctcctgag tagctgagat tacaggtgcc caccaccacg cccagctaaa tttttttgta 291360tttttagtag agatggggtt tcacaaggtt ggccaggctg gttttgaact cctgacctca 291420ggtgatccac ccgcctcagc ctcccaaagt gctgggatta caggagtgag ccaccatgcc 291480cagcattttc tttctttttt tttttttttt tgaaacggag tcttgttctg tcacccaggc 291540tggagtgcag tggcgcaatc tcggctcact gcaacctcca tctcccgggt tcaagtgatt 291600ctgcctcagc ctcccaagta ggtgggacta cagatgcgtg ccaccacgcc cggataattt 291660tttgtatttt tagtagaaac ggggtttcac catgatagca ggatggtctc gatctcccaa 291720cctcgtgatc tgcccacctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc 291780accgggcctc cggtatttta attatatctg caaagtccct tcatagcctg ggcaatggtc 291840cctagattag tgtttgaata aacagaatct tggcagaagg gcagcttttg aattctgcct 291900accacagttc cttcgtttgt acaacgggtc taacaacacc cccactcttt gtatgtaatg 291960ccatcgtaac tcagcttctg tggcactctg agaatctgtg ttcaggggtc ccaaaaccac 292020ccacaggttc agtgattccc tggaagaact cagaactgag aaaagttttt atactcacag 292080tttattacag tgaaagaata tagattaaaa tctgcaaagg gccgggcacg gtggctcacg 292140cctgtaatcc cagcactttg ggagggcgag gtaggcagat cacttgaggt cacgagttca 292200agaccagcct gaccaacatg gtgaaaccct gtctctacta aaaatacaaa aattagccag 292260gcgtggtggc tggcgccagt aatcccagct acttggaagg ctaaggtagg agaatcactt 292320gagcccagga ggcagaggtt gcagtgagcc gagatcccgc cacttcactc caggctggac 292380agagtgagac tctattagaa aaaaaaaaaa aaaaaaaatc tgcaaagggc ctggcatggt 292440ggcttacgcc tgtaatcctg gcactttggg agggcaaggc gggcagatca cttgaggtca 292500caagtttgag accagcctgg ccaacatggc gaaaccccgt ctctaccaaa aatacaaaaa 292560ttaggcatgg tgccagaccc ctgtaatccc aactactcag gaggctgagg caggagaatc 292620gcttgaccct gggaggcaga ggttgcagtg agctgagact gtgccattgc actccagcct 292680gtgtgacaag atcaaaactc tgtccaaaaa gaaaattagc caggtgtggt ggcatacacc 292740tgtagtccca gctactccag aggctgaggc acaagaatcc tttcaaccca ggagatagag 292800ctacattaag ccaagatcac gccactgcac tccagcctgg gcaacagagc aagactctgt 292860ctcaaacaaa caaacaaatt ccaaaaacat aaaatgcgca aaggaagggc atctggggaa 292920gggtccagga gacaccaggt gcgagcttcc agttgtctgc ctccagtgga gttgcacaga 292980caacgcttaa ttctccctgc agtgtgtgac aacacgcacc gtgtactgcc aaccagggaa 293040gctcacctga gccttggtgc cccagggttt ttattgaggg tttgtcatat aggcagggct 293100gacgtagtta ctcagtctcc agtccctcca gaggtcaaac tgataccacg tggcccaaga 293160ccccaacgat aaatcgcatt gttagaatga actgtatgga aaattatcca ggcgtggcgg 293220cgggcggctg taatcccagc tactggggaa gctgaggcag gagaatcact tgaaactagg 293280aggccgaggt tgcagtgagc caagatcgca ccattgcact ccagcctggg caatagagca 293340aaaacaccat ctcaaaataa ataaataaat agaatgaact gtattggccg ggtacagtga 293400ctcatgccta taatcccagc actttgggag gctgaggctg gaggatcgtt tgaggccagg 293460agttcgagac cagcctaggc aacatagtga gaccctatct ctttttttta aaaaaaaaaa 293520aaaaaaaaaa aaagaatgaa ctatacagtg tggcccaagg ccccctgcta aataaagaca 293580ctcttcaggc aggacatttc aaaggcttag agatcacctc ccaggagcaa gtcaatgggc 293640cagtcctttc atcggaatgt gcagggtttg gacaacacta gcctactgag ctagtcctta 293700ctgcttagca ccccagcttc tatgacacct actggattcc cttcctgagg gtttcaaaga 293760ctcctggaga tgtctctgaa tttggctgtc acagttgtta cttgtacccc agatgccact 293820cagttccctg aagacaatga tcccccagat ttctcagcca ggagcccctc cacctcttgt 293880cctcagtggg tgccaggcct catcctggag ttccacagct gagccaggct ctcggggtta 293940cggaaggtca agagggtgtg gggacaacaa tggaagagtg ataacagtgg cagccctttg 294000agcagatgcg ggtctcagga gaacataacg cgctttcttt tcatagttca gctcactttc 294060taagcacact gagcttcctt tccagcaggc taaggggctg caaagggggt acagattaac 294120ctcattcttc agattctcaa aaatggtgtc accattcatt gctggagact gggagaaagg 294180gggcaagtcc atctcattct ctctgtctct gtctctctct ctctcttccc tgtccatctg 294240tttctctctc ccacccaccc ctctgttctc tctgcccaga agaatctcta ttttggtttt 294300ggttttgttt gttttgtatt gttttgagac ggagtctcgt tctgtcgccc aggctggagt 294360gcagtggcgc agtctcaact caccactgca gcctccacct cccaggttca agcgattctc 294420atgcctcagc ctcccgagta gttgggatta caggcgcacg ccaccacgcc cagctaattt 294480ttgcattttt actagagact ggtttcacca tgttgaccag gctggaccct atcctctttc 294540aagcccccca ccccaggcat tgagggcaga gccaactacc tgcctgaacc aattagcata 294600ttaaacgtaa acccagttag catatccaaa tagcagccca cagtgacatt ctgactgtca 294660gaatgtggat tgcttgagcc caggagctca aggcttcggt gaacaaagat tgtgccacag 294720cctgggcaac agagtaagtc cctgtcgatc gatagataga tgatagatag atagatagat 294780agatagatag atagatagat agatagatag ataaattttt aaaaaaaata ataggccagg 294840cacagtggct catgcctgta atcccagcac tttgggaggc cgaggcaggc agatcacctg 294900aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccctgtctct acaaaaatat 294960aaaaatagcc aggcagatgt ctgtaatccc agctactcag gaggctgagg taggagaatc 295020gcttgaactc tgaaggtgga ggttgcagtg agccgagatc atgccattgc actccagcct 295080gagtgacaga gcgagactcc atctcaaaaa taataacaat aataaaaata ataataaatg 295140ctctggcccc aaagtggcac attacatggt gcacacccca ttagcaagga ctcatcacat 295200ggccctgcca accacaggag gaaccccccc atgtactcag gtaggagggc caggaaacac 295260cgtcagagag ctttaatgac tcaccccatg actggggtga gggacgaggg actggctgca 295320ggccaagggc atgtccgtgg cagtggagac ttgggaaagg ggaaaagacc tcctctgagc 295380cacgcacagt ggctttcatc tgtaattcca gcactttggg aggctgaggt gggaggatct 295440tgagcccagg aggtcgagac tgcagtgagc tatgtttgtg ccacggcact ctagcctggg 295500cgacagagca aaaccctgtc tcaaaaatca aaataaaacc aaaaccaaaa cttcctctgt 295560tggggatgct ccagggcgtc ccagccttga acagatgggt cactgcagta ataatcctat 295620ggcagacact gtcccaaggc tgcacgcacg ttactttgat catcaaacaa ccaggtgata 295680gccaggcatg gtggtgcgtg cctgtagtcc cagctactca ggaagctgaa gcgggagaat 295740ctcttgaacc tgggaggcgg aggtaacagt gagtcgagat cacatgactg cacttcagcc 295800tgggaacaga gagagactct gtcaaaaaaa aaaaaaaaac aggccagacg cggtggctca 295860cgcatgtaat cgccagcact ttgggaggct gaggagggtg gatcacctga ggtcaggagt 295920ttgagaccag cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaattagtt 295980gggcgtggtg gtgcacacct gtaatcccag ctactcggga ggctgaggca ggagaatcgc 296040ttgaacccag gaggcagagg ttgcagtgag ctgagattgc accattgcac tccagcctgg 296100gcaacaagag tgaaactcca tctcaaaaaa aaaacaaaaa aaaaacaacc agccaggcgc 296160ggtggcttac gcctgtaatc ccagcacttt gggaggccga ggcgtgtgga tcacccgagg 296220ttaggagttc gagaccagct tgaccaacat ggtgaaactc cgtctctact aaaaatacaa 296280aaaattagcc aggcatggtg gtgcatgtct gtaatcccag ctactcggga agctgagaca 296340ggagaattgc ttgaacccag gagtcggagg ttgcagtgag ccaagctcgt gccactgcac 296400tccagcctgg gcaacagagc aagactctgt ctaaaaaaaa aaaaaaaaca cacacacaca 296460cacacaacaa ccaggtgagg caagtactct tgctatcatc tccatttcac agatggagaa 296520actgagttac taagtggtag agtaacctaa gtcatgcagc cgataactgg gagacaagat 296580tgggacccag gtcgcccagc tgttctccat gccgggctgt ctcctgcaca gctgctccat 296640ggtcctggcc ccaccgaaaa ccagagccca caaggtcatt ccagcagcac tgcccagggc 296700ctcctctggg ccaggccgtt ggggaactgg agaccccatg gggaccagaa agattggggt 296760ctcgttctcg ggagcctatg gctttgcagc tgacccagag tccagctgac acccaggcag 296820gcagtcaggg tctgtctaca cccccattgc aggaggagcc gacaaacagc agatggacgc 296880tgagctgcgg aaggagatga tggcgatttg gcccaatctg tcccagaaga cgctagacct 296940gctggtcaca cctcacaagt gtaagagctg agcccagccc tgggatccaa tccaccagga 297000cagatggagg gggagggaaa ggggaggcct ggggagagtg ttggcctggg ctggtataca 297060cagggaccca ggacaagggc cccaaagagg cctgcccttg gtgagctcac cgtgtgtgtg 297120cccccagcca cggacctcac cgtggggaag atctacgcag ccatgatgat catggagtac 297180taccggcaga gcaaggccaa gaagctgcag gccatgcgcg aggagcaggt gcgctgttcg 297240ccgctctggg gacatctggg ctggggacag tggcttgcat gtcaccacgg gaaccaactg 297300gaatatgagg gtggctgagc cccagggcag gtccctgaaa agtaggggct gtgcacagca 297360gctcacacct gcaatctcag tgctttgaga ggccagggca gagggatcgt ttgagaccag 297420gatgagacca ccctgggcaa cacagtgaga ctccatctct acaaaataaa acattagcca 297480ggcatggtgg tgcacacctg tagtcccagc tatttaggag gccaagatgg gaggatcact 297540tgaggccagg agtgggagac cagtctgggc aacatagaaa gacccatatc tctacaaaaa 297600aaaaataaaa ttagctgcat gtggcgccat gcacctgtgg tcccagctac ttgggaggct 297660gaggcaggag aatcacttga acctgggagg tggaggttgc agcaagccaa gatcaagcca 297720ctgcactcca gcccgggtga taagagcagg actctatctc aaaaaaaaaa aaaaaaaaaa 297780aaaaaaaagt tcttgccaag gacacatcat gtggattcat tcttcattca gctgctccac 297840caacacttat tgagtattac tgtgtgcagg gcgctgttct cagtcctcgg ggatgcaccc 297900atggggaaaa taggccagaa tccctgccct cagggagcag acattccaag tggggaaatg 297960ccaatggtag caaatgactg aatcgtgcaa catccagcaa agagaaagaa agtgtcgtgg 298020gggaaagtgg agaagaatcc agaagatagg agtatccagg ggaggagggg atgcggtggg 298080aaatgggtag ttggggagcc tccctgagaa agtgacatgt gagcaaaggc ttgaaggaaa 298140aggggagagg gagtgagcta agcaatacct ggaagggtgt tccaggcaga ggaaacagcc 298200agtgcaaagg ctctgaggct ggaccgtgcc tgggttgttt gggtaacagc aaagaggcca 298260gtgtggtgga aaagagcagg gaggagacaa gggcaaggag gtgacagggc agatccttca 298320gggccatggg agctgcagga aggactctgg ctttttcccc aagcaagtgg gagccatgga 298380gggttctaag caaaggaggg ataggacctg actcaagtgc tcatgggcgc cctctggtgg 298440ctcttgtgga acagtggggt tgaaggtagg agcgggagac ctgggagaag gtgcctgcag 298500tgagagatga ggacgtggga ccaggctggg gctatgactt gggtggagga gtgagaagtg 298560gtccagttct gcgtggaatt ggaagggtct agatggatga gacctgagag agtgtgtgtg 298620tgtgtgtgtg tgtatactgg ggatgtcgca atgccttctg ggtaccaccg tcccaccacc 298680ccacccttgt ccacacactg ctctctgccc cattccccag gaccggacac ccctcatgtt 298740ccagcgcatg gagcccccgt ccccaacgca ggaaggggga cctggccaga acgccctccc 298800ctccacccag ctggacccag gaggagccct gtgagtgtca cccctgccag ggaggtggag 298860tgtgggggtg ccgtggtccc cacgttctgg aagctgccca agcgcccact gctaccccgg 298920cctctgtccc ccatgcagga tggctcacga aagcggcctc aaggagagcc cgtcctgggt 298980gacccagcgt gcccaggaga tgttccagaa gacgggcaca tggagtccgg aacaaggccc 299040ccctaccgac atgcccaaca gccagcctaa ctctcaggtg cctctgtccc ccaactcccc 299100aatggctccc agggcccggg tggttcaggt ggaagggatc tgggcccccc acacacacac 299160acctgcagct ccctccctct gcagacacca gggatctgga ggtcaggccc cagagctcat 299220ctggctttgc catctgctcc gcagtccgtg gagatgcgag agatgggcag agatggctac 299280tccgacagcg agcactacct ccccatggaa ggccagggcc gggctgcctc catgccccgc 299340ctccctgcag agaaccaggt gagggctttc accactgccc tggggctgga cccctcactc 299400tgcactgggt agggccaggc ccccccacaa gcagcccagt gcatcccctc cctgccggac 299460tcaggcctgg gtagggactc cttcagtctc tgaagcagtc tgcaggcccc acccaccacc 299520tggtcacacc tggagcacct gcagaccctc ctccctcaca gaggacagag aggaaagtgc 299580tccccctggg gcagagggca gtggccactg caaaatggtc tctggctgcc ctggttggag 299640gctgcagaca ggggaggttg tggaagattt gtgggtgcag cagggttcaa cagggccagc 299700tgagacctgc cacgaagatc acccctacac aaacacacac acacatgctc aacatacatg 299760cacacacatg tgcagctgtg cgcctactca gatgcttgca tacacacacg tgtgtgcacg 299820tgggcatata cacactgcac atgtactcac acatgcacac atgtacgtgc acacgtgtct 299880gcatatggga acttggcagg tcctaggata cagtagcaga gtctggggtg ggtctggggg 299940cagctgggct cgtattttct gtctggtctc tgtgggagtc attggggggc acaggggtgt 300000gtgcttgatg tgtgtctgtg tgtggccgct tcacccagct gccaggccca cctgcaggtg 300060atcccgttgc cttggactca tgggacagag ggcccagagg catagctggc tgcccacccg 300120gcctgaacag cgggggccca tgcacgcagc ccgcctctgg aggagaacag ggcatggctg 300180tgagagcctg gcccgggtgc gtggcatgtg tggctgtggc gagctttccg tgtgccgtgt 300240gtggcgtctg cacggggcag gaggctgtgc tgtgcctggc tggaccaggg tcacctgagg 300300gcctggcctc tggctgctgg gaacgtgggt tggggagcac ccagcgtgca tgctgctgct 300360ccctcaggac cgagctgctg ggccccagga gagggttggg acaagcccag ctgacggcca 300420ccacatggaa gctttgagca tcggccggag ccaggggttg gggtgtgcat cgcatgaggc 300480agagcccagg gccaggggct cgaggctgcg ccgtcctgtc tttcggtccc atgcctctgc 300540catttgtctg tctgcatctc ctgtctgtct cctctgtacc catgggaata gaggacgccc 300600agccccgggg gcctgggaca cccacccgcc aggactttaa cttttctttt cctccctgcc 300660ttctccctcc gatttctctt gatgccagtg ccactcccct ccttggcttc ttctccatgc 300720accacctcct cactctccct cttgcctttt atatttattt tcttctttct gttttttctg 300780tgtgcaccat cccatggggc tgtgacagag gagaaggggc cggccacgtg ggaataacct 300840cagtgtatgt accgcgcctg cccagcgccc agcagggctc cggccccctc ttcctcccca 300900ccccccctcc agggagtccc gtcatctctc accgtccccg gaccccaccc tttctttggc 300960aatcgcaccc tctcccctcc atggagccca atccttgtgt gtggtgtcct gtgtgtgccc 301020ctcacccata agccctggtg ggcggggcca tccccatcct cacccctacc cccttttctt 301080cagggccccc cacgccggag gacactggct ctccaagagc ctggcccact ctgcacctct 301140ttctgggggg cttcttctcc tgacaccacc accaacccct

ggtcctgcag ctcctacctg 301200gagcagggcc accagcgctc agctgggctg gaccctggga ggcgggcgtc tgccccatct 301260ccctccttcc ctcctctgcc tgctgcagag aaacctgtgt gtcagggctt gacccaggga 301320tgaagcacca gggaaaagag tgggccccca gagcctccag tgcctgggta tcccccaccc 301380ccacccagag ctccctagct tgggcctcac cagaaggact cagacttgtg ggggcagcga 301440gcacagcccc gttagccggg aggacccaaa gctgccatgc cgggcacctg gtcctgagcc 301500cataggtcag ccagccacag tcggaggctt ctcaccctcc caggagagca agctggggca 301560gggatgagtg cggcagtcca gggctcccag gtttgcaccc tggatgtgga gagggcttcc 301620ctctggccag cctgagcctg cccaactgtg gctgggcccc caggactgga gagtgaggat 301680cagatctttc tggtcagaac ccaggatggg ctcaaaagga gcagtcctgt ctctgaggga 301740cagaggaatc ctcaggctcc accctcagag gcctggccac acccagagcc ctgattgatc 301800agggggagcc aaggccccat ggcatcccct ggcccctgcc ccaggatggt cacaccgcag 301860tcaccgaagg ccaccaccag gctgccacaa tggggcagga aggaccggga ccacttggtg 301920ctagctgctg accccagccc accggcctgt cccctccccc agaccatctc agacaccagc 301980cccatgaagc gttcagcctc cgtgctgggc cccaaggccc gacgcctgga cgattactcg 302040ctggagcggg tcccgcccga ggagaaccag cggcaccacc agcggcgccg cgaccgcagc 302100caccgcgcct ctgagcgctc cctgggccgc tacaccgatg tggacacagg tgggcagccc 302160tgtggtgctc agggacaagc agaacagagg agaggagagg ggaggagaag gcagggcgga 302220ggagacacta aggaagaaga aagggagagg cctccatgga gaggggacag agggggccag 302280gcagcagctg caggaacctg ggtactaccc cctcccccca acccactgac ctgcctcggt 302340tcaggggatc tctagggccc ccacaccttc caggtggcct cctgtgtgtg catctgcccc 302400acctctccct cacgaccacc tgtgtgtctg tctgaccctc acccggccca ggcttgggga 302460cagacctgag catgaccacc caatccgggg acctgccgtc gaaggagcgg gaccaggagc 302520ggggccggcc caaggatcgg aagcatcgac agcaccacca ccaccaccac caccaccacc 302580atcccccgcc ccccgacaag gaccgctatg cccaggaacg gccggaccac ggccgggcac 302640gggctcggga ccagcgctgg tcccgctcgc ccagcgaggg ccgagagcac atggcgcacc 302700ggcaggtggg tgcggctgca agtgacccca ggctgggctc ggccgggagg cggggaggag 302760agaaggggat accccatcca acagccactc taggcaaagg tccccggatc ccggctgtga 302820ccacctccca tcctgccccc aagccaccgg ggtgcccggc ggccggagcg gacacggatc 302880cccaccacac cagctgccta tgctgtcccc ccagccccct tgcccacccg ccgccccctc 302940cccgccgccc gcagctgctt gctcctcggt tgtggatcat atttgagttc tgggccgtgc 303000cgcccgacct ttcactttcc tttaacccgg cttctgtttt tgtttcaatt atgatttctg 303060tcctctggac gcctgtgagt aatttttgaa acttctgcta tttttaaccc cgaaacttac 303120aaaactccat ttctcatttc tcttttcact ttgttgtgtt ggttttcgac tcctcccctc 303180cctgtctcac tccccctcct cccctccctc ctccctgtgg ctgttgcttt tttccattca 303240atgtcctgtg tcccccctct cctcctcctc ctcctcctcc ccctccccct cctccctctc 303300ctcccggccc ctctcccttc gctcccctct cttcctccca atcccgtgtc tcctttgatt 303360ttgttgtatc tttttttttg atttcctttg tttcaatttt cgtgtagggc agtagttccg 303420taagtggaag cccagccccc tcaacatctg gtaccagcac tccgcggcgg ggccgccgcc 303480agctccccca gaccccctcc accccccggc cacacgtgtc ctattcccct gtgatccgta 303540aggccggcgg ctcggggccc ccgcagcagc agcagcagca gcagcagcag cagcagcagc 303600aggcggtggc caggccgggc cgggcggcca ccagcggccc tcggaggtac ccaggcccca 303660cggccgagcc tctggccgga gatcggccgc ccacgggggg ccacagcagc ggccgctcgc 303720ccaggatgga gaggcgggtc ccaggcccgg cccggagcga gtcccccagg gcctgtcgac 303780acggcggggc ccggtggccg gcatctggcc cgcacgtgtc cgaggggccc ccgggtcccc 303840ggcaccatgg ctactaccgg ggctccgact acgacgaggc cgatggcccg ggcagcgggg 303900gcggcgagga ggccatggcc ggggcctacg acgcgccacc ccccgtacga cacgcgtcct 303960cgggcgccac cgggcgctcg cccaggactc cccgggcctc gggcccggcc tgcgcctcgc 304020cttctcggca cggccggcga ctccccaacg gctactaccc ggcgcacgga ctggccaggc 304080cccgcgggcc gggctccagg aagggcctgc acgaacccta cagcgagagt gacgatgatt 304140ggtgctaagc ccgggcgagg tggcgcccgc ccggcccccc acgcacccca cgcacacacc 304200ccacccgagg agccgcgcag aggccgcggg ggcccagcac agagggcccg ggagagggcc 304260agccgggaga ccccagactc tggagaggcc agggctgggc cacaagggtg tcccgcagag 304320accctcggcc aaaagagacc ctcctgggca gccacggcgc cccccaacca gccccgatcc 304380ccccacccac gacaggggct ctcgggtggg aggcagggag cagacaaacc acacagccaa 304440gggatttgaa ttaactcagc catttttgga gaactttggg gaacatgaaa aaaaaaaaaa 304500aaaaaaaaaa aaaaaacatt tttaaaagaa aaaacgggga gaaaaaaata gcttctattg 304560atgagtttta tcatctcaat tgaatctttc ctttccctga tgaagacagc tggtggccga 304620gtgcggcaaa gaagccagaa ggaaccagaa tcccagtgcc ctacacccac caccagacac 304680actcacaccc acacacgttc tcagacacac acaagagtgc ttgccggtta taccaaaccc 304740tactattact gcctgcagaa atcaatttaa aaaaataata ataacaataa acaattttaa 304800aaaggacaaa aaaattaatg attgagaaaa gaggcatttt tttctgacat ttggtcctgc 304860ttgaaacaac aaaagaagaa gaaaaaccca ccatcaccac cgattccttt gcttcttttt 304920tccttttttc ctaccttgtt tgaaaaccgt gggcttggga ctgtgaatta ttgcatgaca 304980ttcaaaaaga aaaaaaaaat aaaaaaaagt tgaatcaaag ggcttttgga taggagtggt 305040ctttgtccct tggctaggtg ctgcctgggt gggtctctct tggggaatca tacaaagagg 305100cacttctttg ttagctccta gaagcactgt ttgaaagcga caaggaggcc gggcatcatg 305160cacgcctgta atcccagcac tttgggaggc taaggcagat ggatcacttg aggtcaggag 305220ttcgagacca gcccgaccaa catggcaaaa cctcatctct actaaaaata caaaaaaaat 305280tagccatgcg tggttgcaca aactgtaatc ccagctactc cggaggctga ggcatgagaa 305340tcacctgagc ctgagaggcg gaggttagca gtgagccaag atcccaccac tgcactccag 305400cctgagtgac ggaatgagac tcttgtctca aaataaaaaa aaaaaaggca gggcgcggtg 305460gctcacgcct ataatcccag cactttggga ggccgaggtg ggtggatcac atgaggtcag 305520gagttcacaa ccagcctggc caacatagtg aaacgccgtc tttactacaa atacaaaaat 305580tagccacgcg tggtggtggg tgcctgtaat cccagctact cgggaagctg aggcaggaga 305640attgcttgaa cccaggaggc ggaggttgca gtgaaccaag atcgtgccac tgcactccaa 305700cctgggtgac agagcaagac tccatcttag ataattaata ataataattt ggtctcgtgg 305760acaccaaccc ccgcccccac gaagtgtttc agccatcccc agagtccaat acccctttga 305820gagcttctgt tctcacaaca gtacctgacc catagcaagc tactattgac tatcaccatt 305880actactgtag cattaaggca aacattttga acaggtcttg ttccagacaa caggccctgc 305940ttgagcttac cttgggtaag aaatctgcag actccagata gcaagacagg tgtaagtcct 306000tctaaaataa tggtaagcca aatgtggtgg cacacacctg tagtcccagc tgttcaggag 306060gctgaggcag gaggatcact tgagcccacg aggtcaagac cagctatgat cacacctgtg 306120aataaccatt gcattccagc ctgggtgacg tagaaagatc ccatctctaa aaaaattaaa 306180agtaaaaata aataaataaa ataatggcat ctaggaaaag atcagtccaa cgagaagtca 306240aagttttgag gtcgagtgcg gtgtctgact cttgtaatct caacactttg ggagaatcac 306300ttgaggccag tagttcaaga ccagcctggg caacatagca agacgctgtc tctaaaaaaa 306360aaagtttgtt ttttttaagg ctgggtacag aggctcacgc ctgtaatccc agcactttgg 306420gaggccaagg tgagcagatc accaagtcag gagtttgaga ccagcctggc caacatagtg 306480aaaccctgtc tctactaaaa ataaaaaaat tagccaggtg tggtggtgca tgcctatatt 306540cccagatact tggcaggctg aggcaggaaa atcgcttgaa cctgggaggc agaggttgca 306600gtgagctgag attgcgtcac tgcactgcag cctgggcgac agagtgagac tacgtctcaa 306660aaaaaaaaaa aaaaaaaaat ggaatggaag ggagggaggg aggggtttaa ctttctaacc 306720aggcaatctg gcaaccacca caggcttcta aacaagctgc ccatccattg cagagctggc 306780ctctggtccc cctcccatgg tgctggggtt gagtgtgtcc aggagccact ggagtaagcc 306840agggtttgtg caattccctc tgctgtcaat gaggctgcag ccatctgtcc tcccaggaat 306900gaagttcact accgaagccc cccatgagcc ctgaactcaa aggccaagtc tatgcccgag 306960tgccaagagg tagacccaag gcctccacag tgcacatcat caggctagag tgttagttg 307019

Claims

1-68. (canceled)

69. A method for alleviating and/or treating a channelopathy in a subject in need thereof, comprising administering to the subject a compound of Formula II ##STR00010## wherein Ar is aryl, which is unsubstituted or substituted with at least one electron-donating group and/or at least one electron-withdrawing group; R₁ is alkyl; and R₃ is selected from the group consisting of hydrogen, alkyl, arylalkyl, alkoxy, alkoxyalkyl, aryl, a heterocyclic group, heterocyclic alkyl, N-alkoxy-N-alkylamino, N-alkoxyamino, and N-carbalkoxy; or a pharmaceutically acceptable salt thereof; wherein the channelopathy is an epilepsy syndrome.

70. The method of claim 69, wherein, in the compound of Formula II, R₃ is --CH₂-- alkoxy and/or R₁ is methyl.

71. The method of claim 69, wherein, in the compound of Formula II, Ar is phenyl which is unsubstituted or substituted with at least one halo group.

72. The method of claim 69, wherein said compound is (R)-2-acetamido-N-benzyl-3-methoxypropionamide; (R)-2-acetamido-N-benzyl-3-ethoxypropionamide; O-methyl-N-acetyl-D-serine-m-fluorobenzylamide; or O-methyl-N-acetyl-D-serine-p-fluorobenzylamide.

73. The method of claim 69, wherein the compound is in the R configuration.

74. The method of claim 69, wherein the compound is lacosamide.

75. The method of claim 69, wherein the epilepsy syndrome is a disease associated with dysfunction of a voltage-gated ion channel or a ligand-gated ion channel.

76. The method of claim 69, further comprising administering to the subject at least one further active agent for alleviation and/or treatment of a channelopathy.

77. The method of claim 69, wherein the epilepsy syndrome is associated with a mutation at SCN1A, SCN2A, CACNB4, KCNQ2, KCNQ3 or CHRNA4.

78. The method of claim 69, wherein the epilepsy syndrome is selected from the group consisting of generalized epilepsy with febrile seizures plus, severe myoclonic epilepsy in infancy, benign familial neonatal infantile seizure, intractable childhood epilepsy with generalized tonic-clonic seizure and infantile spasms.

79. The method of claim 69, wherein the epilepsy syndrome is selected from the group consisting of benign familial neonatal convulsions 1, benign familial neonatal convulsions 2 and nocturnal frontal lobe epilepsy.

80. The method of claim 69, wherein the compound of Formula (II) or a pharmaceutically acceptable salt thereof is administered in a dosage amount of 50 mg/day to 1000 mg/day.

81. The method of claim 69, wherein the compound of Formula (II) or a pharmaceutically acceptable salt thereof is administered in a dosage amount of 200 mg/day to 600 mg/day.

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