Patent application number | Description | Published |
20120026881 | PACKET CLASSIFICATION IN A NETWORK SECURITY DEVICE - Methods and apparatuses are described for inspecting data packets in a computer network. One or more data packets through the network have associated header data and content. One method includes receiving a data packet, examining the data packet to classify the data packet including classifying the data packet using information included in the header and content, determining flow instructions for processing the packet based on both the header information and the content and processing of the packet using the flow instructions. | 02-02-2012 |
20120166599 | MANAGING NETWORK DEVICES - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for managing network devices. A central management system stores shared configuration objects in a central configuration database. A network device stores shared configuration objects and device-specific configuration objects in a local configuration database. The local configuration database's shared configuration objects correspond to shared configuration objects in the central configuration database. The network device can be configured locally or using the central management system. | 06-28-2012 |
20120324064 | MANAGING NETWORK DEVICES - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for configuring network devices. A central management system stores shared configuration objects in a central configuration database. A network device stores shared configuration objects and device-specific configuration objects in a local configuration database. The local configuration database's shared configuration objects correspond to shared configuration objects in the central configuration database. The central management system determines the network device has received a request to update a shared configuration object, where the request did not originate from the central management system, and updates the central configuration database. | 12-20-2012 |
20130198348 | MANAGING NETWORK DEVICES - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for managing network devices. A central management system stores shared configuration objects in a central configuration database. A network device stores shared configuration objects and device-specific configuration objects in a local configuration database. The local configuration database's shared configuration objects correspond to shared configuration objects in the central configuration database. The network device can be configured locally or using the central management system. | 08-01-2013 |
20130298222 | HIGH AVAILABILITY SECURITY DEVICE - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for processing a first plurality of packets using one or more processors and maintaining one or more flow records associated with the first plurality of packets, and processing a second plurality of packets without maintaining flow records associated with the second plurality of packets and allowing the second plurality of packets to pass to one or more destinations. | 11-07-2013 |
20130318198 | MANAGING NETWORK DEVICES - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for configuring network devices. A central management system stores shared configuration objects in a central configuration database. A network device stores shared configuration objects and device-specific configuration objects in a local configuration database. The local configuration database's shared configuration objects correspond to shared configuration objects in the central configuration database. The central management system determines the network device has received a request to update a shared configuration object, where the request did not originate from the central management system, and updates the central configuration database. | 11-28-2013 |
20140075539 | PACKET CLASSIFICATION IN A NETWORK SECURITY DEVICE - Methods and apparatuses are described for inspecting data packets in a computer network. One or more data packets through the network have associated header data and content. One method includes receiving a data packet, examining the data packet to classify the data packet including classifying the data packet using information included in the header and content, determining flow instructions for processing the packet based on both the header information and the content and processing of the packet using the flow instructions. | 03-13-2014 |
20140119376 | L2/L3 MULTI-MODE SWITCH INCLUDING POLICY PROCESSING - Methods and apparatus for processing data packets in a computer network are described. One general method includes receiving a data packet; examining the data packet to classify the data packet including classifying the data packet as a L2 or L3 packet and including determining at least one zone associated with the packet; processing the packet in accordance with one or more policies associated with the zone; determining forwarding information associated with the data packet; and if one or more policies permit, forwarding the data packet toward an intended destination using the forwarding information. | 05-01-2014 |
20140331311 | SECURITY PROCESSING IN ACTIVE SECURITY DEVICES - Methods, systems, and apparatus, including computer program products, featuring receiving at a first security device a packet. The first security device determines that the packet is associated with a flow assigned to a distinct second security device. The first security device sends the packet to the second security device. After the second security device performs security processing using the packet, the first security device receives from the second security device a message regarding the packet. The first security device transmits the packet. | 11-06-2014 |
20150026794 | PACKET CLASSIFICATION FOR NETWORK ROUTING - Techniques for packet classification for network routing are disclosed. In some embodiments, packet classification for network routing includes receiving packets associated with a new flow at a security controller from a network device, in which the network device performs packet forwarding; classifying the flow; and determining an action for the flow based on a policy (e.g., a security policy). In some embodiments, the network device is a Software Defined Network (SDN) network device (e.g., a packet forwarding device that supports the OpenFlow protocol or another protocol). | 01-22-2015 |
20150055657 | APPLICATION BASED PACKET FORWARDING - Methods, systems, and apparatus, including computer program products, featuring receiving at a network device a plurality of packets associated with a flow, one or more of the plurality of packets having associated header data and content. Based on the content of one or more first packets in the plurality of packets, the network device identifies an application associated with the flow, where none of the first packets is addressed to the network device. For one or more second packets associated with the flow, the network device determines a forwarding destination for the second packets based on the application associated with the flow and forwards the packet according to the determined forwarding destination. | 02-26-2015 |
20150195291 | IDENTIFICATION OF MALWARE SITES USING UNKNOWN URL SITES AND NEWLY REGISTERED DNS ADDRESSES - In some embodiments, identification of malware sites using unknown URL sites and newly registered DNS addresses includes performing a heuristic analysis for information associated with a network site; and assigning a score based on the heuristic analysis, in which the score indicates whether the network site is potentially malicious. In some embodiments, the system includes a security appliance that is in communication with the Internet. In some embodiments, the network site is associated with a network domain and/or a network uniform resource locator (URL). In some embodiments, performing a heuristic analysis for information associated with a network site further includes determining if a network site has recently been registered. In some embodiments, performing a heuristic analysis for information associated with a network site further includes determining if a network site is associated with recently changed DNS information. In some embodiments, performing a heuristic analysis for information associated with a network site further includes determining geographical information as well as an IP network location associated with the network site. | 07-09-2015 |
20160094516 | HIGH AVAILABILITY SECURITY DEVICE - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for processing a first plurality of packets using one or more processors and maintaining one or more flow records associated with the first plurality of packets, and processing a second plurality of packets without maintaining flow records associated with the second plurality of packets and allowing the second plurality of packets to pass to one or more destinations. | 03-31-2016 |
Patent application number | Description | Published |
20080253366 | L2/L3 MULTI-MODE SWITCH INCLUDING POLICY PROCESSING - Methods and apparatus for processing data packets in a computer network are described. One general method includes receiving a data packet; examining the data packet to classify the data packet including classifying the data packet as a L2 or L3 packet and including determining at least one zone associated with the packet; processing the packet in accordance with one or more policies associated with the zone; determining forwarding information associated with the data packet; and if one or more policies permit, forwarding the data packet toward an intended destination using the forwarding information. | 10-16-2008 |
20100220727 | PACKET PROCESSING IN A MULTIPLE PROCESSOR SYSTEM - Packet processing is provided in a multiple processor system including a first processor to processing a packet and to create a tag associated with the packet. The tag includes information about the processing of the packet. A second processor receives the packet subsequent to the first processor and processes the packet using the tag information. | 09-02-2010 |
20100242093 | INTELLIGENT INTEGRATED NETWORK SECURITY DEVICE FOR HIGH-AVAILABILITY APPLICATIONS - Methods and apparatuses for inspecting packets are provided. A primary security system may be configured for processing packets. The primary security system may be operable to maintain flow information for a group of devices to facilitate processing of the packets. A secondary security system may be designated for processing packets upon a failover event. Flow records may be shared from the primary security system with the secondary security system. | 09-23-2010 |
20120084426 | PACKET PROCESSING IN A MULTIPLE PROCESSOR SYSTEM - Packet processing is provided in a multiple processor system including a first processor to processing a packet and to create a tag associated with the packet. The tag includes information about the processing of the packet. A second processor receives the packet subsequent to the first processor and processes the packet using the tag information. | 04-05-2012 |
20130067268 | INTELLIGENT INTEGRATED NETWORK SECURITY DEVICE FOR HIGH-AVAILABILITY APPLICATIONS - Methods and apparatuses for inspecting packets are provided. A primary security system may be configured for processing packets. The primary security system may be operable to maintain flow information for a group of devices to facilitate processing of the packets. A secondary security system may be designated for processing packets upon a failover event. Flow records may be shared from the primary security system with the secondary security system. | 03-14-2013 |
20130074184 | PACKET PROCESSING IN A MULTIPLE PROCESSOR SYSTEM - Packet processing is provided in a multiple processor system including a first processor to processing a packet and to create a tag associated with the packet. The tag includes information about the processing of the packet. A second processor receives the packet subsequent to the first processor and processes the packet using the tag information. | 03-21-2013 |
20140259146 | INTELLIGENT INTEGRATED NETWORK SECURITY DEVICE - Methods, computer program products and apparatus for processing data packets are described. Methods include receiving the data packet, examining the data packet, determining a single flow record associated with the packet and extracting flow instructions for two or more devices from the single flow record. | 09-11-2014 |
Patent application number | Description | Published |
20100132030 | INTELLIGENT INTEGRATED NETWORK SECURITY DEVICE - Methods, computer program products and apparatus for processing data packets are described. Methods include receiving the data packet, examining the data packet, determining a single flow record associated with the packet and extracting flow instructions for two or more devices from the single flow record. | 05-27-2010 |
20110185426 | DETECTION OF NETWORK SECURITY BREACHES BASED ON ANALYSIS OF NETWORK RECORD LOGS - Computer program products and methods of inspecting a log of security records in a computer network are provided. The method includes retrieving a log record, processing the log record including deriving a key to a table, determining a data value from information in the log record and adding the data value to a list of data values associated with the key if the data value is unique. One or more entries of the table are evaluated based on predetermined criteria to detect attempted security breaches. | 07-28-2011 |
20130067560 | MULTI-METHOD GATEWAY-BASED NETWORK SECURITY SYSTEMS AND METHODS - Systems and methods for detecting and preventing network security breaches are described. The systems and methods present a gateway-based packet-forwarding network security solution to not only detect security breaches but also prevent them by directly dropping suspicious packets and connections. The systems and methods employ multiple techniques to detect and prevent network security breaches, including stateful signature detection, traffic signature detection, and protocol anomaly detection. | 03-14-2013 |
20130067561 | INTELLIGENT INTEGRATED NETWORK SECURITY DEVICE - Methods, computer program products and apparatus for processing data packets are described. Methods include receiving the data packet, examining the data packet, determining a single flow record associated with the packet and extracting flow instructions for two or more devices from the single flow record. | 03-14-2013 |
20130067575 | DETECTION OF NETWORK SECURITY BREACHES BASED ON ANALYSIS OF NETWORK RECORD LOGS - Computer program products and methods of inspecting a log of security records in a computer network are provided. The method includes retrieving a log record, processing the log record including deriving a key to a table, determining a data value from information in the log record and adding the data value to a list of data values associated with the key if the data value is unique. One or more entries of the table are evaluated based on predetermined criteria to detect attempted security breaches. | 03-14-2013 |
Patent application number | Description | Published |
20110027879 | Adipose-derived stem cells and lattices - The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 02-03-2011 |
20120208274 | ADIPOSE-DERIVED STEM CELLS AND LATTICES - The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 08-16-2012 |
20130217118 | ADIPOSE-DERIVED STEM CELLS AND LATTICES - The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 08-22-2013 |
20150376572 | ADIPOSE-DERIVED STEM CELLS AND LATTICES - The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 12-31-2015 |
Patent application number | Description | Published |
20090068694 | Enzyme Activity Measurements Using Bio-Layer Interferometry - Disclosed are enzyme assays using biolayer interferometry. Assays may be carried out using immobilized substrate or with a substrate capture format. In certain embodiments, the assays are carried out using unlabeled substrates. The methods are broadly applicable to enzyme assay measurements, can be carried out in vivo or in vitro, and are easily multiplexed. | 03-12-2009 |
20100093106 | Amine-Reactive Biosensor - Described are methods, articles of manufacture, and kits for coupling an analyte-binding molecule to the surface of a biosensor through formation of amide bonds. One amide bond is formed between a first carboxyl group on a polymer and a first reflecting surface comprising an aminoalkyl moiety. A second amide bond is formed between a second carboxyl group on the polymer and an amine group on an analyte-binding molecule to be coupled. The present invention thus provides for covalent attachment of the analyte-binding molecule to the biosensor, thus providing advantages over non-covalent attachment methods of the prior art. These advantages include the ability to couple without using bio tin (which, in some instances can alter functional properties of a molecule) the ability to improve the fidelity with which a binding or dissociation reaction that takes place on the surface of the biosensor represents a solution phase reaction, and the ability to regenerate the sensor by stripping ligands from the covalently bound analyte-binding molecule. | 04-15-2010 |
20100261288 | TIP TRAY ASSEMBLY FOR OPTICAL SENSORS - An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed. | 10-14-2010 |
20110268610 | Tip Tray Assembly For Optical Sensors - An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed. | 11-03-2011 |
Patent application number | Description | Published |
20110305599 | OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER - The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer. | 12-15-2011 |
20110312105 | DETECTION SYSTEM AND METHOD FOR HIGH SENSITIVITY FLUORESCENT ASSAYS - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked Ficoll molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 12-22-2011 |
20130040378 | IMMUNOASSAY CUVETTES - The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound. | 02-14-2013 |
20130041141 | FLUORESCENT POLYMER COMPOSITION - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 02-14-2013 |
20130052081 | DETECTION SYSTEM FOR HIGH SENSITIVITY FLUORESCENT ASSAYS - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 02-28-2013 |
20130071952 | LUMINESCENT POLYMER CYCLIC AMPLIFICATION - The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise. | 03-21-2013 |
20130273667 | WIDE RANGE LUMINESCENT IMMUNOASSAYS - The present invention relates to a method for quantitating an analyte having a wide range concentration in a single assay without having to dilute the sample and repeating the assay. The key feature of the invention is having two cycles of events including sample binding to probe, binding reactions, and detection. After the first cycle of binding and detecting, the probe is dipped into the same sample vessel to bind additional analyte in the sample vessel at a condition that is more favorable to binding than the condition in the first cycle. | 10-17-2013 |
20130295591 | SYSTEMS FOR IMMUNOASSAY TESTS - This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules; (b) a sample well to receive a sample; (c) one or more reagent wells; (d) a plurality of wash wells each containing a first aqueous solution; and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution; wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test. | 11-07-2013 |
20140093432 | OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER - The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer. | 04-03-2014 |
20140128596 | CROSSLINKED POLYSACCHARIDE - This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels. | 05-08-2014 |
20140295578 | SYSTEMS FOR IMMUNOASSAY TESTS - This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules, (b) a sample well to receive a sample, (c) one or more reagent wells, (d) a plurality of wash wells each containing a first aqueous solution, and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution, wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test. | 10-02-2014 |
20150204795 | OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER - The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer. | 07-23-2015 |
20150276724 | LUMINESCENT POLYMER CYCLIC AMPLIFICATION - The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise. | 10-01-2015 |