Zipfel
Cyril Zipfel, Norfolk GB
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20080307539 | Methods, Means and Compositions for Enhancing Agrobacterium-Mediated Plant Cell Transformation Efficiency - Higher eukaryotes sense microbes through perception of pathogen-associated molecular patterns (PAMPs). The flagellin receptor FLS2 represents so far the only known pattern recognition receptor (PRR) in | 12-11-2008 |
Cyril B. Zipfel, Norwich GB
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20100122376 | METHODS OF ENHANCING THE RESISTANCE OF PLANTS TO BACTERIAL PATHOGENS - Methods are provided for enhancing the resistance of plants to bacterial pathogens. The methods involve transforming a plant with a polynucleotide molecule comprising a plant promoter operably linked to a nucleotide sequence that encodes a plant receptor that binds specifically with bacterial elongation factor-Tu. Further provided are expression cassettes, transformed plants, seeds, and plant cells that are produced by such methods. | 05-13-2010 |
Greg Zipfel, University City, MO US
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20140377319 | ALTERING PROTEIN CONCENTRATIONS IN CEREBROSPINAL FLUID AND/OR BRAIN INTERSTITIAL FLUID - Devices and methods of altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid are disclosed. Devices include a support having at least one protease attached to the support. The device may further include a housing. Devices may be implantable for use in an in vivo active flow system or for use in an in vivo passive system. Devices may also be used in an ex vivo active flow system. Devices may also be used in a passive system to treat cerebrospinal fluid and/or brain interstitial fluid that is withdrawn, or in a passive system that is implanted surgically. Methods include contacting cerebrospinal fluid and/or brain interstitial fluid with a support including at least one protease attached to the support. Proteins contained in the cerebrospinal fluid and/or brain interstitial fluid are cleaved by the protease resulting in the reduction of protein in cerebrospinal fluid and/or brain interstitial fluid. Additionally, methods are disclosed for treating neurodegenerative diseases and neurological disorders. | 12-25-2014 |
Gregory Zipfel, St. Louis, MO US
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20120035359 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention encompasses phenoxazine derivatives and methods of use thereof. | 02-09-2012 |
20140221647 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention encompasses phenoxazine derivatives and methods of use thereof. | 08-07-2014 |
20150175589 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention encompasses phenoxazine derivatives and methods of use thereof. | 06-25-2015 |
Gregory J. Zipfel, St.louis, MO US
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20090149912 | Method for electrical modulation of neural conduction - Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed. | 06-11-2009 |
Johannes Zipfel, Düsseldorf DE
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20100249007 | Cleaning Agents - Two-phase or multi-phase washing or cleaning agent comprising a) a bleaching agent, b) a bleach activator, c) a bleach catalyst selected from the group of bleach intensifying transition metal salts and transition metal complexes, wherein bleaching agent a) is present together with at least one of the components b) and c) in a phase of the washing or cleaning agent, the agent having improved cleaning performance, particularly for bleachable stains. | 09-30-2010 |
Johannes Zipfel, Hilden DE
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20090194562 | METERING APPARATUS FOR FLOWABLE COMPOSITIONS - A metering apparatus for flowable preparations includes a metering unit having an energy source, a control unit and a sensor unit. A container for a first flowable preparation, such as a detergent, cleaning agent, or fragrance, is removably couplable to the metering unit. A micropump that has a specific delivery quantity of less than 500 l/min is provided in the metering unit. The micropump can be controlled by the control unit to dispense flowable product from the container into a desired system external to the metering apparatus, such as a dishwasher, washing machine, toilet, air freshening system, and the like. | 08-06-2009 |
20090239778 | Cleaning Agent - The invention relates to a combination product comprising a packaging means and two liquid washing or cleaning agents A and B of composition A, which are located in said packaging means while being separated from one another therein. Composition A consists of: 10 to 75% by weight of builder(s); 0.1 to 10% by weight of enzyme(s); 24.9 to 89.9% by weight of water, and composition B consists of: 10 to 74.9% by weight of builder(s); 25 to 89.9% by weight of water, and; 0.1 to 15% by weight of bleaching agent. The invention is characterized in that the liquid cleaning agent A has a pH value (20° C.) ranging from 6 to 9 and is characterized by having an improved cleaning efficiency compared to that of conventional solid or liquid dishwashing cleaning agents. | 09-24-2009 |
Lothar Zipfel, Laatzen DE
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20090286898 | HYDROFLUOROCARBON COMPOSITIONS - A composition which comprises 1,1,1,3,3-pentafluorobutane (HFC-365mfc) and 1,1,1,3,3-pentafluoropropane (HFC-245fa) in a weight ratio HFC-365mfc/HFC-245fa of from 60:40 to 75:25. | 11-19-2009 |
20100174005 | Mixtures Containing 1,1,1,3,3-Pentafluorobutane and 1,1,1,2,3,3,3-Heptafluoropropane - Blowing-agent mixtures containing HFC-365mfc, HFC-227ea and one or both of 1,1,1,3,3-pentafluoropropane and 1,1,1,2-tetrafluoroethane are disclosed; as well as non-combustible polyether polyol and/or polyester polyol premixes for producing foamed products, in particular polyurethane foams. | 07-08-2010 |
20150246997 | HYDROFLUOROCARBON COMPOSITIONS - A composition which comprises 1,1,1,3,3-pentafluorobutane-(HFC-365mfc) and 1,1,3,3-pentafluoropropane (HFC-245fa) in a weight ratio HFC-365mfc/HFC-245fa of from 60:40 to 75:25. | 09-03-2015 |
Marzellinus Zipfel, Freiburg DE
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20140207022 | Method for the mask-etching of a piercing element - A method is disclosed for the mask-etching of a piercing element having an elongate shaft, a distally protruding tip, a proximal holding part, and a laterally open collecting channel that collects bodily fluid and extends along the shaft as far as the area of the tip, wherein a side of a double-sided etching mask is applied respectively to the two sides of a substrate and, under the action of an etching agent, the piercing element is formed as a part made by chemical blanking, wherein a channel side of the etching mask is provided with a channel etching slit for unilateral etching of the collecting channel. | 07-24-2014 |
Peter Zipfel, Jena DE
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20090118163 | Factor H for the Treatment of Chronic Nephropathies and Production thereof - The invention is directed to novel uses of Factor H, in particular in antibody-independent chronic nephropathies, e.g. in tubulointerstitial fibrosis (TIF). The invention is further directed to novel large scale manufacturing processes for Factor H. | 05-07-2009 |
20110046062 | FACTOR H FOR THE TREATMENT OF CHRONIC NEPHROPATHIES AND PRODUCTION THEREOF - The invention relates to the use of Factor H for the manufacture of a medicament to treat both chronic nephropathies which are not causally associated with proteinuria and chronic nephropathies which are causally associated with proteinuria. The invention also relates to large scale purification methods for Factor H. | 02-24-2011 |
20110236455 | Novel Regulators of the Innate Immune System - The present invention relates to the identification of novel regulators of the innate immune system, in particular the complement system. More particularly, the present invention relates to specific C5 convertase inhibitors. These novel inhibitors are particularly useful for treating inflammatory diseases involving the complement system. In a first aspect, the present invention focuses on the use of CFHR proteins and functional fragments or functional derivatives thereof for preventing inflammatory reactions. In a further aspect, the present invention focuses on the use of said CFHR proteins for inactivating complement activation during transplantation and dialysis and for coating devices which come into contact with blood or body fluids, in particular implants. The invention furthermore provides a pharmaceutical composition comprising functional CFHR protein in combination with functional factor H. In a further aspect, the present invention focuses on providing monoclonal antibodies which specifically detect CFHR proteins, and on the use thereof in methods of determining CFHR in body fluids. These methods are particularly suitable for diagnosing inflammatory diseases. | 09-29-2011 |
Robert Zipfel, Augsburg DE
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20140173811 | Unit composed of helmet and protective eye mask - Unit composed of helmet and goggles, comprising a helmet cap and an eye protection element that is configured so as to be placed in front of the wearer's face. The upper edge of the eye protection element is adapted to the profile of the lower front edge of the helmet cap. A magnetic device is arranged on the two edges and has a first series of permanent magnets which are rigidly connected to one of the two edges and interact, by magnetic attraction, with complementary elements that are provided on the opposite edge. This front magnetic connection area between the two edges furthermore comprises tilt orientation means of the goggles for adjusting the contact with the face. | 06-26-2014 |
Sheila Zipfel, Mountain View, CA US
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20100125092 | 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS - The invention relates to compounds of formula I: | 05-20-2010 |
20110230495 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS - The invention relates to compounds of formula I: | 09-22-2011 |
Sheila Zipfel, San Mateo, CA US
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20130030020 | 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS - The invention relates to compounds of formula I: | 01-31-2013 |
20130156732 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 06-20-2013 |
20130164260 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 06-27-2013 |
20130177530 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 07-11-2013 |
20130324550 | 1-(2-PHENOXYMETHYLHETEROARYL) PIPERIDINE AND PIPERAZINE COMPOUNDS - The invention relates to compounds of formula I: | 12-05-2013 |
20140017198 | INHIBITORS OF HEPATITIS C VIRUS - Compounds of Formula I are disclosed | 01-16-2014 |
20140018313 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 01-16-2014 |
20140057944 | 4-[2-(2-FLUOROPHENOXY METHYL)PHENYL]PIPERIDINE COMPOUNDS - The invention relates to compounds of formula I: | 02-27-2014 |
20140112885 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 04-24-2014 |
20140274884 | INHIBITORS OF HEPATITIS C VIRUS - Compounds of formula I: | 09-18-2014 |
20140309432 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 10-16-2014 |
20150038488 | SYK INHIBITORS - The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I | 02-05-2015 |
20150071878 | NOVEL INHIBITORS OF HEPATITIC C VIRUS - The invention provides compounds of formula (I): | 03-12-2015 |
20150141326 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 05-21-2015 |
20150175655 | INHIBITORS OF HEPATITIS C VIRUS - Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed. | 06-25-2015 |
20150299213 | ANTIVIRAL COMPOUNDS - The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 10-22-2015 |
Sheila M. Zipfel, San Mateo, CA US
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20150353529 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 12-10-2015 |
Shella Zipfel, San Mateo, CA US
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20120114600 | NOVEL INHIBITORS OF HEPATITIS C VIRUS - The invention provides compounds of formula (I): | 05-10-2012 |
Toni Zipfel, Meitingen DE
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20140248042 | Vaporizer - A vaporizer for an exhaust system of an internal combustion engine has a vaporizer tube and a holding sleeve in which the vaporizer tube is inserted. A clamping sleeve sits on the vaporizer tube. The vaporizer tube includes two circumferentially surrounding clamping surfaces which protrude in a radial direction and cooperate with the holding sleeve and the clamping sleeve such that the clamping surfaces are clamped between the holding sleeve and the clamping sleeve by an axial clamping force to be gastight. At least one of the holding sleeve and the clamping sleeve includes a surrounding sealing edge which rests against the respective clamping surface via a line contact and forms an annular sealing seat. The vaporizer further includes a device preventing relative rotation between the holding sleeve and the vaporizer tube. A heater of the vaporizer is attached to the vaporizer tube using a resistance welding method. | 09-04-2014 |
Warren Zipfel, Ithaca, NY US
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20120293863 | FLUORESCENCE COLLECTION OBJECTIVE OPTICAL SYSTEM AND METHOD - An optical system particularly suited for non-linear fluorescence collecting includes a front lens system, a rear lens system, and a bulk, dichroic beam splitting component intermediate the front lens system and the rear lens system to direct the fluorescent emission from a target object to a photodetector. A lens housing may have a reflective coating on an interior surface thereof. The objective optical system is particularly advantageous for use in cases where large fields of view and high collection efficiencies are desirable. | 11-22-2012 |
Warren R. Zipfel, Ithaca, NY US
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20130331653 | MICROSCOPE APPARATUS, METHOD AND APPLICATION - A microscope apparatus and a microscopic method that uses the microscope apparatus for examining a sample or a specimen, such as but not limited to a tissue sample or a tissue specimen, includes a convex curved distal exit window at a distal end of the microscope apparatus. Due to the presence of the convex curved distal exit window, the microscope apparatus may readily make contact with the sample or the specimen absent trauma to the sample or the specimen. In addition, an index of refraction matched immersion fluid may be used for focusing the microscope apparatus by hydraulic movement of an objective optic lens assembly interior to the distal exit window with respect to the distal exit window. The convex curved distal exit window and index of refraction matched immersion fluid characteristics may be extended to various microscope apparatuses and methods, and in particular medical microscope apparatuses and methods. | 12-12-2013 |