Zhu, MD
Chenzi Zhu, Gaithersburg, MD US
Patent application number | Description | Published |
---|---|---|
20100074164 | Communication Systems - A method for transmission of information about downlink and uplink parameters of a intermediate apparatus link in a multi-hop wireless communication system, the system comprising a first node apparatus, a second node apparatus and one or more intermediate apparatuses, each said apparatus being operable to transmit and receive information along a series of links forming a communication path for downlink and uplink communication, the communication path extending between the first node and second node apparatuses via the or each intermediate apparatus, each link comprising either a first node link between the first node apparatus and a said intermediate apparatus or an intermediate apparatus link between a said intermediate apparatus and a said apparatus which is not the first node apparatus, and the system having access to a minimum allocation unit for allocating time and transmission frequency bandwidth, the method comprising: obtaining values of downlink and uplink parameters for a particular intermediate apparatus link; mapping both values onto a single minimum allocation unit and transmitting them towards the first node apparatus. | 03-25-2010 |
Frank Q. Zhu, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20080204966 | Controlled Transport and Assembly of Nanostructures - Systems and methods for manipulating nanostructures, such as nanospheres, nanodisks, nanowires, and nanotubes. The systems and methods permit the construction of nano-scale contacts, scaffolds, and motors using electric fields that do not require the use of toxic nanostructure materials. The electric fields are imposed on the nanostructures using electrodes having specific shapes and driven with voltages having particular amplitudes, frequencies, and phase differences. The electrode shape and voltage characteristics influence the configuration of the electric fields, which in turn influences the ultimate configuration of the nanostructures. The nanostructures retain their configuration after the electric fields and any transport medium, such as deionized water, are removed. | 08-28-2008 |
He Zhu, Timonium, MD US
Patent application number | Description | Published |
---|---|---|
20130211239 | MAGNETIC RESONANCE IMAGING CONCEPTS - A method for producing multiple temporal frames of a time-resolved contrast enhanced magnetic resonance angiogram from a subject using an MR contrast agent by repeatedly applying RF pulses and sampling data in the corresponding image k-space along spiral trajectories that start at the k-space center and spiral outward toward the k-space edge. | 08-15-2013 |
Heng Zhu, Towson, MD US
Patent application number | Description | Published |
---|---|---|
20130288910 | METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES - Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies. | 10-31-2013 |
20160060687 | METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES - Proximity coupling and sequencing methods to screen identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation. | 03-03-2016 |
Heng Zhu, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20100294046 | System and Methods for Sampling Materials - Provided herein are systems and methods for storage, retrieval and sampling of materials. | 11-25-2010 |
20110136692 | PROTEIN MICROARRAYS FOR MASS SPECTROMETRY AND METHODS OF USE THEREFOR - The present invention relates to the use of mass spectrometry to analyze arrays. The present invention provides methods for characterizing solutions comprising one or more proteins using arrays and mass spectrometry. The arrays of the present invention are coated with porous gold and utilize hydrophobic and hydrophilic self-assembled monolayers. | 06-09-2011 |
20110251100 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND RELATED DISORDERS - The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases. | 10-13-2011 |
Jianfeng Zhu, Frederick, MD US
Patent application number | Description | Published |
---|---|---|
20080207555 | HYDROLASE AND METHODS FOR ITS USE - This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein. | 08-28-2008 |
Jianwei S. Zhu, Frederick, MD US
Patent application number | Description | Published |
---|---|---|
20150197734 | REVERSIBLE REGULATION OF INTEIN ACTIVITY THROUGH ENGINEERED NEW ZINC BINDING DOMAIN - Disclosed are compositions comprising an engineered intein designed such that the self-cleaving activity of the intein can be modulated by a zinc-binding motif as well as DNA methods and systems for making and using the compositions. | 07-16-2015 |
Jing Zhu, Ellicott City, MD US
Patent application number | Description | Published |
---|---|---|
20140303203 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS - Compounds and methods for treating or preventing a neurodegenerative disease, disorder or condition associated with the overall activity of hsp90 but not with the ATPase activity of hsp90, including peripheral neuropathy, such as peripheral neuropathy caused by chemotherapy or diabetes, disorders 5 of the central nervous system, such as Alzheimer's disease and Parkinsons disease, and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), in a subject are provided. | 10-09-2014 |
Joshua Zhu, Highland, MD US
Patent application number | Description | Published |
---|---|---|
20160099851 | METHOD AND SYSTEM FOR OPTICAL CONNECTION VALIDATION IN A RECONFIGURABLE OPTICAL ADD-DROP MULTIPLEXER (ROADM) NODE - A method of validating connections in an optical add/drop multiplexer (OADM) that includes a plurality of modules configured to route optical signals through the OADM, and at least one multi-fiber cable connecting modules of the OADM. A light source coupled to a first port of a first module is controlled to emit a test light. A determination is made whether or not the test light is received at a first photo-detector connected to a second port. Continuity of a connection between the first port and the second port is validated when the test light is received at the first photo-detector. | 04-07-2016 |
Peixuan Zhu, Derwood, MD US
Patent application number | Description | Published |
---|---|---|
20100279322 | Direct detection of intracellular fluorescently tagged cells in solution - A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension are introduced to a fluorometer to specifically identify and quantitate the target cells. The target cells can be lysed or whole when introduced to the fluorometer. | 11-04-2010 |
20140302526 | ZAP-70 DETECTION IN CHRONIC LYMPHOCYTIC LEUKEMIA - Detection of ZAP-70 expression provides important information about disease progression and overall survival in patients with chronic lymphocytic leukemia (CLL). The invention provides methods for diagnosing CLL in a subject, as well as methods for clearly distinguishing CLL patients with aggressive form of the disease. A consistent number of B cells from patient blood is isolated and lysed to release all of the intracellular ZAP-70 protein. The released ZAP-70 protein is subsequently extracted by immunomagnetic separation followed by detection with fluorescence immunosandwich assay. The ZAP-70 fluorescence signal is measured with Signalyte™-II spectrofluorometer. The VeriZAP™ assay is a simple, reliable, and reproducible method for quantitative detection of ZAP-70 in patient leukemic cells, and can be used as a prognostic test to distinguish indolent versus aggressive CLL patients. | 10-09-2014 |
20140315295 | POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF - A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells. | 10-23-2014 |
20160021872 | URINE PRESERVATIVE REAGENT FOR MICROFILTRATION - A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents. | 01-28-2016 |
Peixuan Zhu, Potomac, MD US
Patent application number | Description | Published |
---|---|---|
20110182981 | GONOCOCCAL VACCINES - The present invention relates to immunogenic compositions comprising a recombinant | 07-28-2011 |
Ping Zhu, Germantown, MD US
Patent application number | Description | Published |
---|---|---|
20100156601 | LLRP-Based Flexible Reader System And Method - A system includes a host computing device, a first RFID transceiver, and at least one second RFID transceiver. The host computing device executes an application according to a predetermined RFID communication protocol. The predetermined RFID communication protocol supports communication only with a single RFID transceiver. The first RFID transceiver communicates with the host computing device according to the predetermined RFID communication protocol. The at least one second RFID transceiver communicates with the first RFID transceiver. The at least one second RFID transceiver provides data to the host computing device only via the first RFID transceiver. | 06-24-2010 |
Qing Zhu, Bethesda, MD US
Patent application number | Description | Published |
---|---|---|
20100297165 | IMMUNOSTIMULATORY COMBINATIONS OF TLR LIGANDS AND METHODS OF USE - The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions. | 11-25-2010 |
Qing Zhu, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20100017895 | Small animal model for hcv replication - An animal model for HCV replication and/or production of virus or virus like particles is provided. The invention utilizes an HCV replicon present in a cell to deliver HCV nucleic acid and replicate and express HCV proteins in an animal model comprising an animal that has been immunocompromised. The invention further provides a method of treatment or prevention of HCV in a mammal which comprises administering to the mammal a combination which comprises an immunomodulatory compound and another antiviral agent. Also provided are cell lines showing a decreased sensitivity to interferon alpha or some other immunomodulator and methods of making or isolating such cell lines. | 01-21-2010 |
20150125479 | ANTIBODIES AGAINST AND METHODS FOR PRODUCING VACCINES FOR RESPIRATORY SYNCYTIAL VIRUS - The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection. | 05-07-2015 |
Qing Zhu, Gaithersburg, MD US
Patent application number | Description | Published |
---|---|---|
20120156235 | Antibodies Against And Methods For Producing Vaccines For Respiratory Syncytial Virus - The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection. | 06-21-2012 |
Shiqui Zhu, Potomac, MD US
Patent application number | Description | Published |
---|---|---|
20140378389 | T CELL RECEPTORS RECOGNIZING HLA-A1- OR HLA-CW7-RESTRICTED MAGE - The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention. | 12-25-2014 |
Shuren Zhu, Potomac, MD US
Patent application number | Description | Published |
---|---|---|
20100087469 | Natural product derivatives with antimalarial activity - The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria. | 04-08-2010 |
20100292264 | Small molecules with antiprotozoal activity - The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria. | 11-18-2010 |
20130023552 | Small molecules with antimalarial activity - The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria. | 01-24-2013 |
20140100240 | Natural product derivatives with antiprotozoal activity - The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria. | 04-10-2014 |
Weidong Zhu, Elkridge, MD US
Patent application number | Description | Published |
---|---|---|
20080294354 | System and method for detecting structural damage - A system and method for detecting structural damage is provided that utilizes a general order perturbation methodology involving multiple perturbation parameters. The perturbation methodology is used iteratively in conjunction with an optimization method to identify the stiffness parameters of structures using natural frequencies and/or mode shape information. The stiffness parameters are then used to determine the location and extent of damage in a structure. A novel stochastic model is developed to model the random impact series produced manually or to generate a random impact series in a random impact device. The random impact series method or the random impact device can be used to excite a structure and generate vibration information used to obtain the stiffness parameters of the structure. The method or the device can also just be used for modal testing purposes. The random impact device is a high energy, random, and high signal-to-noise ratio system. | 11-27-2008 |
Weidong Zhu, Ellicott City, MD US
Patent application number | Description | Published |
---|---|---|
20140123787 | GEARED INFINITELY VARIABLE TRANSMISSION - An infinitely variable transmission (IVT) to provide a continuous output-to-input speed ratio from zero to a certain value is designed, and its working principle is illustrated. It is a geared IVT (GIVT), since its function to achieve the continuously varied speed ratio is implemented by gears. Crank-slider systems are used in the GIVT; the output-to-input speed ratio is changed with the crank length. Racks and pinions, whose motion is controlled by planetary gear sets, are used to change the crank length when the cranks are rotating. One-way bearings are used to rectify the output speeds from different crank-slider systems to obtain the output speed of the GIVT. Since the crank-slider systems can introduce variations of the instantaneous speed ratio, a pair of noncircular gears is designed to minimize the variations. A direction control system is also designed for the GIVT using planetary gear sets. Finally, a vehicle start-up simulation and a wind turbine simulation to maintain a constant generator speed are developed based on a GIVT module in the Matlab Simulink environment. | 05-08-2014 |
20150214821 | Active Control System for a Variable Electromotive-Force Generator with Applications to Wind Turbines, Ships, and Hybrid Vehicles - This invention relates to an active control system for a variable electromotive-force generator (VEG) for use in wind turbines, ships, hybrid vehicles, and related applications. | 07-30-2015 |
Weizhong Zhu, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20140187645 | PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE - This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease. | 07-03-2014 |
Weizhong Zhu, Cockeysville, MD US
Patent application number | Description | Published |
---|---|---|
20100168245 | PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE - This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease. | 07-01-2010 |
20120157543 | PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE - This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease. | 06-21-2012 |
Xiaoping Zhu, Clarksville, MD US
Patent application number | Description | Published |
---|---|---|
20120213780 | Efficient mucosal vaccination mediated by the neonatal Fc receptor - The present invention relates to methods and compositions for enhancing delivery of vaccine antigens to the mucosal epithelium, the composition comprising an antigen from an infectious agent fused with an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn). The composition is effective in eliciting a protective long-term memory T cell immune response against infection at a distant mucosal site. | 08-23-2012 |
20130108618 | METHODS AND COMPOSITIONS RELATED TO INTRACELLULAR NEUTRALIZATION BY IgG | 05-02-2013 |
20160024187 | METHODS AND COMPOSITIONS RELATED TO INTRACELLULAR NEUTRALIZATION BY IgG - Disclosed are compositions, antibodies, and methods for binding intracellular antigens. | 01-28-2016 |
Yongfei Zhu, Ellicott City, MD US
Patent application number | Description | Published |
---|---|---|
20100073103 | METHODS FOR TUNING AN ADAPTIVE IMPEDANCE MATCHING NETWORK WITH A LOOK-UP TABLE - Methods for generating a look-up table relating a plurality of complex reflection coefficients to a plurality of matched states for a tunable matching network. Typical steps include measuring a plurality of complex reflection coefficients resulting from a plurality of impedance loads while the tunable matching network is in a predetermined state, determining a plurality of matched states for the plurality of impedance loads, with a matched state determined for each of the plurality of impedance loads and providing the determined matched states as a look-up table. A further step is interpolating the measured complex reflection coefficients and the determined matching states into a set of complex reflection coefficients with predetermined step sizes. | 03-25-2010 |
20120056689 | METHODS FOR TUNING AN ADAPTIVE IMPEDANCE MATCHING NETWORK WITH A LOOK-UP TABLE - Methods for generating a look-up table relating a plurality of complex reflection coefficients to a plurality of matched states for a tunable matching network. Typical steps include measuring a plurality of complex reflection coefficients resulting from a plurality of impedance loads while the tunable matching network is in a predetermined state, determining a plurality of matched states for the plurality of impedance loads, with a matched state determined for each of the plurality of impedance loads and providing the determined matched states as a look-up table. A further step is interpolating the measured complex reflection coefficients and the determined matching states into a set of complex reflection coefficients with predetermined step sizes. | 03-08-2012 |
Zhonghua Zhu, Highland, MD US
Patent application number | Description | Published |
---|---|---|
20150098700 | Distributed Optical Switching Architecture for Data Center Networking - A system has a first rack with a first set of servers and a first top of rack switch and a second rack with a second set of servers and a second top of rack switch. A first optical switch is connected to the first top of rack switch. A second optical switch is connected to the second top of rack switch and the first optical switch. The first optical switch and the second optical switch each employ wavelength selective switching. | 04-09-2015 |
Zhonghua Zhu, Essex, MD US
Patent application number | Description | Published |
---|---|---|
20080232738 | SYSTEMS AND METHODS FOR SIDE-LOBE COMPENSATION IN RECONFIGURABLE OPTICAL ADD-DROP MULTIPLEXERS - Systems and methods to reduce passband side-lobes associated with WSS-based ROADMs by applying a filter on each channel are provided. In an exemplary embodiment, a comb filter, such as a thin film filter or an interleaver, is utilized. Additionally, the present invention provides systems and methods to adaptively control amplifier target power and per wavelength target power to maintain signal launching power as per design in networks with WSS-based ROADMs. Accordingly, signal OSNR does not collapse faster than other similar configured system without WSS-based ROADM. In order to correct amplifier target power, the present invention utilizes system information about side-lobe size and OSNR at each amplifier. | 09-25-2008 |
20100183311 | HIGH-DEGREE RECONFIGURABLE OPTICAL ADD-DROP MULTIPLEXING SYSTEMS USING BI-DIRECTIONAL WAVELENGTH SELECTIVE SWITCHES - The present disclosure provides high-degree reconfigurable optical add-drop multiplexing (ROADM) systems using bi-directional wavelength selective switches (WSSs) and optical circulators. A single WSS is utilized on each degree of a node in a bi-directional manner, i.e. both ingress and egress share the same WSS. Advantageously, the present invention eliminates conventional splitters/combiners thereby capping intra-node insertion loss to a certain value regardless of the number of degrees. More importantly, the present invention reduces noise penalty associated with high-degree nodes while minimizing cost. | 07-22-2010 |
Zhongyu Zhu, Frederick, MD US
Patent application number | Description | Published |
---|---|---|
20100055033 | ANTIBODY COMPOSITIONS AND METHODS FOR TREATMENT OF NEOPLASTIC DISEASE - Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided. | 03-04-2010 |
20120064000 | Human Monoclonal Antibodies Against Hendra And Nipah Viruses - The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 03-15-2012 |
20130149246 | Human Monoclonal Antibodies Against Hendra and Nipah Viruses - The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 06-13-2013 |
20140044720 | HUMAN MONOCLONAL ANTIBODIES THAT BIND INSULIN-LIKE GROWTH FACTOR (IGF) I AND II - Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer. | 02-13-2014 |
20140079715 | Human Monoclonal Antibodies Against Hendra and Nipah Viruses - The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 03-20-2014 |
20150071854 | Human Monoclonal Antibodies Against Hendra and Nipah Viruses - The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 03-12-2015 |
20150218255 | CROSS-REACTIVE ANTIBODIES AGAINST DENGUE VIRUS AND USES THEREOF - The invention relates to a human anti-dengue virus antibody (an anti-DENV antibody) that binds to a DENV envelope protein and is cross-reactive with DENV serotype 1, DENV serotype 2, DENV serotype 3, and DENV serotype 4. The disclosure provides an anti-DENV antibody that cross-reacts with and neutralizes all four DENV serotypes. Also provided is a nucleic acid molecule that encodes such an anti-DENV antibody. Also provided is a method to produce and use such an antibody or nucleic acid molecule encoding such an antibody. | 08-06-2015 |
20160024199 | HUMAN MONOCLONAL ANTIBODIES THAT BIND INSULIN-LIKE GROWTH FACTOR (IGF) I AND II - Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer. | 01-28-2016 |
20160053017 | ANTI-CD276 POLYPEPTIDES, PROTEINS, AND CHIMERIC ANTIGEN RECEPTORS - Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. | 02-25-2016 |