Patent application number | Description | Published |
20090157732 | NETWORKED ADDRESS BOOK - A device receives one or more contacts provided in an address book associated with a user, and receives profile information associated with one or more other users. The device also links the profile information with one or more corresponding contacts provided in the address book, and provides the address book with the linked profile information to one or more user devices associated with the user. | 06-18-2009 |
20100153410 | DISTRIBUTING AND SHARING CONTENT IN A NETWORK - A method may include receiving, from a first user device associated with a user profile, a first request for a media file and streaming the media file over a network to the first user device in a first format appropriate for the first device. The method may also include stopping the streaming of the media file and associating a stop time with the stopping, wherein the stop time indicates a position in the media file and receiving, from a second user device different from the first user device, a second request for the media file, the second user device being associated with the user profile. The method may also include streaming, starting at the stop time, the media file over the network to the second user device in a second format appropriate for the second device and different than the first format. | 06-17-2010 |
20110289317 | METHOD AND APPARATUS FOR PROVIDING CONTENT AGGREGATION IN SUPPORT OF VIRTUAL CHANNELS - An approach is provided for content aggregation in support of virtual channels. Query information and authentication information of a user are received from a media application associated with a set-top box. A query request is generated for media content from a content provider using the query information, the authentication information, and an identifier of a service provider. Transmission of the query request is initiated to the content provider system. One or more search results are received in response to the query request. Transmission of the one or more search results is initiated to the media application. | 11-24-2011 |
20120023126 | INTERNET VIDEO CONTENT DELIVERY TO TELEVISION USERS - A method for delivering video content to a user, including accessing a website that hosts a plurality of video content, causing a search to be performed of the website based on a keyword in the set of keywords, identifying, based on a result of the search, a set of video content, of the plurality of video content, related to the keyword, identifying a format of a particular video content in the set of video content, determining whether the format is compatible with a video client device, and outputting identifying information that identifies the particular video content when the format is compatible with the video client device, where the identifying information allows the video client device to access the particular video content. | 01-26-2012 |
20120117599 | THUMBNAIL PUBLICATION - A video service provider system may include one or more devices. The one or more device may receive thumbnails of programs that are currently airing on a group of television channels and match the received thumbnails with metadata. The metadata may include information relating to at least one of the television channels or the programs. The one or more devices may further provide, to a remote device, a set of thumbnails, of the captured thumbnails, and the metadata matching the set of thumbnails. The remote device may make the set of thumbnails and the metadata available to a user. | 05-10-2012 |
20120158713 | RANKING MEDIA CONTENT FOR CLOUD-BASED SEARCHES - A device receives, from a user device, a search query for media content within a content delivery network. The device identifies a group of relevant media content in the content delivery network, where the identifying is based on the search query, access restrictions of particular media content within the content delivery network, and/or a capability of the user device to present particular types of media content. The device associates sub-scores with each piece of media content in the group of relevant media content, and calculates a total score, for each piece of media content in the group of relevant media content, based on the sub-scores. The device ranks each piece of media content in the group of relevant media content, based on the total scores for each piece of media content, and sends, based on the search query, a list of the ranked, relevant media content to the user device. | 06-21-2012 |
20130074168 | STREAMING VIDEO AUTHENTICATION - One or more devices transmit, to a user device, an application for secure mobile streaming, and receive, from the user device, a registration request for the application. The registration request includes a user ID and a unique device identifier (UDID) for the user device. The one or more devices initiate a validation procedure for the user ID or UDID. When the user ID or UDID is validated, the one or more devices generate a device-token for the user device. The device-token includes a hash value based on information in the registration request and an expiration date for the device-token. The one or more devices send the device-token to the user device via a private network. The device-token is required to permit the user device to receive a secure content stream via a public network. | 03-21-2013 |
20130191258 | BILLING AND CREDIT FOR CONTENT IN A CROSS-PLATFORM SYSTEM - A method includes identifying a subscription event for a digital service subscription for digital content. A billing cycle for the digital content is identified. The method includes determining whether an associated credit cycle for physical content is based on the identified billing cycle. The method also includes determining a billing action for the digital content based on the identified subscription event and the identified billing cycle. A credit action for physical content credits is determined based on the identified subscription event and the associated credit cycle in response to a determination that the associated credit cycle is based on the identified billing cycle. The method further includes determining a credit action for the physical content credits based on the identified subscription event and a maximum credit counter in response to a determination that the associated credit cycle is not based on the identified billing cycle. | 07-25-2013 |
20140289773 | THUMBNAIL PUBLICATION - A video service provider system may include one or more devices. The one or more device may receive thumbnails of programs that are currently airing on a group of television channels and match the received thumbnails with metadata. The metadata may include information relating to at least one of the television channels or the programs. The one or more devices may further provide, to a remote device, a set of thumbnails, of the captured thumbnails, and the metadata matching the set of thumbnails. The remote device may make the set of thumbnails and the metadata available to a user. | 09-25-2014 |
Patent application number | Description | Published |
20080279785 | Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications - The invention relates to the therapeutic use of oligonucleotides as immune modulatory agents in immunotherapy applications. More particularly, the invention provides immune modulatory oligonucleotide compositions for use in methods for generating an immune response or for treating a patient in need of immune modulation. The immune modulatory oligonucleotides of the invention preferably comprise novel pyrimidines and purines. | 11-13-2008 |
20090060898 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response - The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen. | 03-05-2009 |
20090081198 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE - The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen. | 03-26-2009 |
20090087388 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE - The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen. | 04-02-2009 |
20090098063 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE - The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus. | 04-16-2009 |
20100035967 | MODULATION OF TOLL-LIKE RECEPTOR 9 EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES - Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR9. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR9. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR9 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR9 expression and for prevention or treatment of diseases wherein modulation of TLR9 expression would be beneficial are provided. | 02-11-2010 |
20100041734 | MODULATION OF TOLL-LIKE RECEPTOR 7 EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES - Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR7. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR7 expression and for prevention or treatment of diseases wherein modulation of TLR7 expression would be beneficial are provided. | 02-18-2010 |
Patent application number | Description | Published |
20110318323 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome. | 12-29-2011 |
20110318324 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF B-GALACTOCEREBROSIDASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an B-Galactocerebrosidase protein, salt, and a polysorbate surfactant for the treatment of GLD Disease. | 12-29-2011 |
20120014936 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF HEPARAN N-SULFATASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A. | 01-19-2012 |
20130295071 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF B-GALACTOCEREBROSIDASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an B-Galactocerebrosidase protein, salt, and a polysorbate surfactant for the treatment of GLD Disease. | 11-07-2013 |
20140271598 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome. | 09-18-2014 |
Patent application number | Description | Published |
20110299311 | Power Generation System, Power Converter System, And Methods Of Converting Power - A power converter system includes an inverter including a first bridge and a second bridge, wherein each of the first bridge and the second bridge includes at least one switch. The power converter system also includes an inductor including a first winding coupled to an output of the first bridge and a second winding coupled to an output of the second bridge. | 12-08-2011 |
20130076135 | High-Power Boost Converter - A high-power boost converter including two or more inductors coupled to an input DC power source and to switches that can be modulated to control the output power of the high-power boost converter. The two or more inductors are further coupled to each other electrically, magnetically, or both electrically and magnetically. | 03-28-2013 |
20130077367 | SYSTEMS AND METHODS FOR USE IN GRID FAULT EVENT CONTROL - System, power modules, and methods for supplying an output voltage to an electric grid are provided. One example power module includes a switching device configured to supply an output from a power generator to an electric grid, a feedback unit configured to provide a feedback signal indicative of a deviation of a parameter associated with the electric grid, and a controller coupled to the feedback unit and the switching device. The controller is configured to adjust a reactive current of the output in response to at least one grid fault event to ride through the at least one grid fault event, to modify the deviation provided from the feedback unit, to control the switching device based on the modified deviation, and to detect an islanding condition based on the parameter associated with the electric grid. | 03-28-2013 |
20130100720 | POWER CONVERTER SYSTEMS AND METHODS OF OPERATING A POWER CONVERTER SYSTEM - A power converter system includes a converter, a DC link, an inverter, a damping circuit, and a control system. The converter includes an input to couple to a power generation unit and an output to provide a direct current (DC) DC power output. The DC link includes a capacitor coupled to the converter output. A voltage across the capacitor defines a DC link voltage. The inverter includes an input coupled to the DC link. The damping circuit is coupled between the converter and the inverter in parallel with the DC link capacitor. The damping circuit includes a normally closed switching device, and a resistor coupled in series with the normally closed switching device. The control system is coupled to the damping circuit and configured to control the normally closed switching device as a function of at least one operating parameter of the power converter system. | 04-25-2013 |
20130119763 | PRECHARGING AND CLAMPING SYSTEM FOR AN ELECTRIC POWER SYSTEM AND METHOD OF OPERATING THE SAME - A power converter includes a plurality of direct current (DC) conduits and a precharging and clamping circuit coupled to the DC conduits. The precharging and clamping circuit includes at least one diode, at least one switching device coupled in parallel with the diode, and at least one contactor device coupled to an alternating current (AC) source and the diode. The at least one contactor device is configured to facilitate alternating said precharging and clamping circuit between precharging operation and voltage clamping operation. | 05-16-2013 |
20130222951 | FAULT PROTECTION CIRCUIT FOR PHOTOVOLTAIC POWER SYSTEM - A fault protection scheme for a photovoltaic power converter system is provided. According to aspects of the present disclosure, a fault protection circuit is coupled between a power converter and a ground reference. The fault protection circuit includes a fuse and a current sensor coupled in series with the fuse. A controller is configured to receive current readings from the current sensor and compare the current readings to a current threshold. The current threshold is selected to be less than the fuse current rating of the fuse. The controller identifies a fault condition if the current flowing through the ground protection circuit exceeds the current threshold value. A contactor can also be provided to temporarily lift the power converter relative to the ground reference to determine the existence of other fault paths in the system. | 08-29-2013 |
20130258732 | SYSTEM AND METHOD FOR REDUCING REACTIVE CURRENT IN POWER CONVERTER BURN-IN TESTS - A system and method for reducing reactive current in burn-in test systems for solar power converters is disclosed. An emulator configured to simulate a DC power source and the power converter subject to the burn-in test can be coupled in a two-unit circulating configuration. An AC feeder line configured to supply power to the two-unit circulating configuration. A controller can be configured to adjust the output of one or more of the emulator and power converter to reduce reactive current flowing in the AC feeder line. For instance, the controller can adjust the modulation of switching devices used in the power converter or emulator to adjust the power factor of various components of the burn-in test system to compensate for the reactive current in the AC feeder line. | 10-03-2013 |
20130279228 | SYSTEM AND METHOD FOR IMPROVING LOW-LOAD EFFICIENCY OF HIGH POWER CONVERTERS - Systems and methods for improving low-load efficiency of power converters are provided. The power converter can include one or more bridge circuits having multiple switching modules, such as insulated gate bipolar transistor (IGBT) modules, connected in parallel within the same bridge circuit. The power converter is configured to convert power from an input power source, such as a photovoltaic array or a wind turbine, into output power at a grid frequency. To avoid excessive switching losses at low load conditions, the power converter can be controlled to selectively operate a subset of the switching modules within the same bridge circuit based on a load condition for the power converter. The remaining switching modules in the bridge circuit can be disabled. | 10-24-2013 |
20130293287 | SYSTEM AND METHOD FOR OPERATING AN ELECTRIC POWER CONVERTER - A regulating system for an insulated gate bipolar transistor (IGBT) includes a clamping circuit coupled to the IGBT. The IGBT is coupled to a gate driver circuit. The regulating system also includes a feedback channel coupled to the clamping circuit. The feedback channel is configured to transmit signals representative of a conduction state of said clamping circuit. The regulating system further includes at least one gate driver controller coupled to the feedback channel and the gate driver circuit. The gate drive controller is configured to regulate temporal periodicities of the IGBT in an on-condition and an off-condition. | 11-07-2013 |
20130301327 | SYSTEM AND METHOD OF PARALLEL CONVERTER CURRENT SHARING - In one aspect, a method of converting power is described. One embodiment of the method comprises receiving direct current (DC) power; channeling the DC power through an inverter including a first bridge and a second bridge, wherein each of the first bridge and the second bridge includes at least one switch; controlling the at least one switch of the first bridge and the at least one switch of the second bridge to convert the DC power to alternating current (AC) power; and, channeling the AC power through an inductor that includes a first winding and a second winding, wherein the first winding is coupled to an output of the first bridge and the second winding is coupled to an output of the second bridge and wherein the inductor is configured to have a first magnetic path for common mode inductance and a second magnetic path for differential mode inductance. | 11-14-2013 |
20140056041 | POWER GENERATION SYSTEM, POWER CONVERTER SYSTEM, AND METHODS OF OPERATING A POWER CONVERTER SYSTEM - A power converter system includes a converter configured to be coupled to a power generation unit for receiving power from the power generation unit, and a bus coupled to the converter, wherein a voltage is generated across the bus when electricity is conducted through the power converter system. The power converter system also includes an inverter coupled to the bus, wherein the inverter is configured to supply power to an electrical distribution network. A control system is coupled to at least one of the converter and the inverter, wherein the control system is configured to adjust an operation of the at least one of the converter and the inverter to reduce the voltage across the bus during at least one of a low voltage event and a high voltage event. | 02-27-2014 |
20140184308 | SYSTEMS AND METHODS FOR CONTROL OF POWER SEMICONDUCTOR DEVICES - A device includes a controller configured to regulate one or more voltages applied to a gate of an insulated gate bipolar transistor (IGBT). The controller is configured to receive one or more voltage values associated with the IGBT, and generate a gating signal and transmit the gating signal to the IGBT. The gating signal is configured to activate or deactivate the IGBT. The controller is configured to generate a voltage clamping signal and transmit the voltage clamping signal to activate or deactivate an active switching device. The active switching device is configured to periodically limit the one or more voltage values associated with the IGBT based at least in part on one or more characteristics of the voltage clamping signal. | 07-03-2014 |
20140293489 | Systems and Methods for Use in Identifying and Responding to Type of Grid Fault Event | 10-02-2014 |
20140301120 | Systems and Methods for Use in Recovering a Converter After Grid Fault Event - Systems, power modules ( | 10-09-2014 |
20150028672 | ISOLATED BATTERY MANAGEMENT SYSTEMS AND METHODS THEREOF - Systems and methods of the invention relate to circuitry that isolates low power circuitry of a battery management system. One or more circuits can be utilized with a battery management system to provide isolation of low power circuitry from at least one of a high voltage, noise interference from a battery, noise interference from a high voltage, sensor signals, control signals, among others. The circuitry further provides high voltage from a grid to be stepped-down to a voltage level usable by circuitry, port(s), and/or a processor. | 01-29-2015 |
20150030901 | BATTERY HEATER SYSTEMS AND METHODS - Systems and methods for supplying power to a battery heater in one or more battery modules. A first DC electrical signal derived from an AC source or a second DC electrical signal derived from a DC bus is used to power a battery heater of one or more battery modules in dependence on a voltage level associated with the first DC electrical signal relative to a voltage level of the second DC electrical signal. | 01-29-2015 |
Patent application number | Description | Published |
20110292980 | DETECTING FAULTS AFFECTING COMMUNICATIONS LINKS - A modem or associated computing or testing device is configured to detect the presence of one or more faults that affect DSL communications, and upon their detection, generate, for example, an indication, communication or message that recommends corrective action. In this context, a fault is generally caused by one or more unfiltered devices, impulsive noises, malfunctioning modems, or other factor that does not affect measured attenuation or measured noise, but does affect the signal-to-noise ratio (SNR) of the link. In addition to being able to generate a message guiding a user through corrective action, the system can estimate the rate impact of the detected fault. | 12-01-2011 |
20120232878 | METHODS AND SYSTEMS FOR DETECTING METALLIC FAULTS AFFECTING COMMUNICATIONS LINKS - One exemplary aspect is to detect the presence of one or more types of faults affecting DSL communications. Upon their detection, a message can be generated that recommends corrective action. Furthermore, another exemplary aspect is to estimate the rate impact of the detected fault in some cases. One exemplary aspect of certain embodiments is to detect the presence of one or more faults that affect DSL communications, and upon their detection, generating, for example, a message that recommends corrective action. In this context, a fault can be one or more metallic faults, malfunctioning modems, or something else that affects the measured attenuation but is not normally attributable to normal DSL transmission lines. | 09-13-2012 |
20140086295 | DETECTING FAULTS AFFECTING COMMUNICATIONS LINKS - A modem or associated computing or testing device is configured to detect the presence of one or more faults that affect DSL communications, and upon their detection, generate, for example, an indication, communication or message that recommends corrective action. In this context, a fault is generally caused by one or more unfiltered devices, impulsive noises, malfunctioning modems, or other factor that does not affect measured attenuation or measured noise, but does affect the signal-to-noise ratio (SNR) of the link. In addition to being able to generate a message guiding a user through corrective action, the system can estimate the rate impact of the detected fault. | 03-27-2014 |
20140269876 | DETECTING FAULTS AFFECTING COMMUNICATIONS LINKS - A modem or associated computing or testing device is configured to detect the presence of one or more faults that affect DSL communications, and upon their detection, generate, for example, an indication, communication or message that recommends corrective action. In this context, a fault is generally caused by one or more unfiltered devices, impulsive noises, malfunctioning modems, or other factor that does not affect measured attenuation or measured noise, but does affect the signal-to-noise ratio (SNR) of the link. In addition to being able to generate a message guiding a user through corrective action, the system can estimate the rate impact of the detected fault. | 09-18-2014 |
Patent application number | Description | Published |
20130096084 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS - The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 04-18-2013 |
20130158020 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS - The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 06-20-2013 |
20130172341 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS - Disclosed are the ERK inhibitors of Formula (I): (Formula (I)) and the pharmaceutically acceptable salts thereof. All substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (I). | 07-04-2013 |
20130237518 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1). | 09-12-2013 |
20130261125 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS - The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R | 10-03-2013 |
20140194404 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES - This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation. | 07-10-2014 |
Patent application number | Description | Published |
20090263347 | ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS - Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues. | 10-22-2009 |
20100133430 | MS METHODS TO EVALUATE GLYCANS - The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans. | 06-03-2010 |
20100196940 | METHODS RELATED TO CELL SURFACE GLYCOSYLATION - The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins. | 08-05-2010 |
20100331266 | ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS - Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. | 12-30-2010 |
20140011727 | Methods of Evaluating Peptide Mixtures - The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying. isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture. | 01-09-2014 |
20140080218 | METHODS OF EVALUATING PEPTIDE MIXTURES - The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture. | 03-20-2014 |
Patent application number | Description | Published |
20100047225 | OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATES THEREOF - The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate. | 02-25-2010 |
20100143297 | METHODS OF ENHANCING LYSOSOMAL STORAGE DISEASE THERAPY BY MODULATION OF CELL SURFACE RECEPTOR DENSITY - Methods of modulating uptake of extracellular lysosomal enzymes by administering a pharmaceutical agent and methods of treating a lysosomal storage disease (such as Gaucher disease, Pompe disease, Fabry disease or Niemann-Pick disease) or enhancing enzyme replacement therapy or gene therapy, comprising administering a pharmaceutical agent such as dexamethasone, glucose or insulin, are provided. | 06-10-2010 |
20100173385 | METHODS FOR INTRODUCING MANNOSE 6-PHOSPHATE AND OTHER OLIGOSACCHARIDES ONTO GLYCOPROTEINS AND ITS APPLICATION THEREOF - Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications. | 07-08-2010 |
20110300120 | OLIGOSACCHARIDE-PROTEIN CONJUGATES - Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate. | 12-08-2011 |
20130177545 | METHODS FOR INTRODUCING MANNOSE 6 PHOSPHATE AND OTHER OLIGOSACCHARIDES ONTO GLYCOPROTEINS AND APPLICATIONS THEREOF - Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications. | 07-11-2013 |
Patent application number | Description | Published |
20090050207 | Photovoltaic Cell - A photovoltaic cell has two electrodes and a hole injection layer. A liquid crystal material and a plurality of particles can be disposed between the electrodes. | 02-26-2009 |
20100032018 | Novel Photoactive Polymers - Novel photoactive polymers, as well as related components, articles, systems, and methods are disclosed. | 02-11-2010 |
20100180944 | Polymers with low band gaps and high charge mobility - Polymers with low band gaps and high charge mobility, as well as related systems, methods and components are disclosed. | 07-22-2010 |
20100307594 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 12-09-2010 |
20100310424 | ORGANIC MATERIALS ABLE TO DETECT ANALYTES - The present invention generally relates to polymers with lasing characteristics that allow the polymers to be useful in detecting analytes. In one aspect, the polymer, upon an interaction with an analyte, may exhibit a change in a lasing characteristic that can be determined in some fashion. For example, interaction of an analyte with the polymer may affect the ability of the polymer to reach an excited state that allows stimulated emission of photons to occur, which may be determined, thereby determining the analyte. In another aspect, the polymer, upon interaction with an analyte, may exhibit a change in stimulated emission that is at least 10 times greater with respect to a change in the spontaneous emission of the polymer upon interaction with the analyte. The polymer may be a conjugated polymer in some cases. In one set of embodiments, the polymer includes one or more hydrocarbon side chains, which may be parallel to the polymer backbone in some instances. In another set of embodiments, the polymer may include one or more pendant aromatic rings. In yet another set of embodiments, the polymer may be substantially encapsulated in a hydrocarbon. In still another set of embodiments, the polymer may be substantially resistant to photobleaching. In certain aspects, the polymer may be useful in the detection of explosive agents, such as 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT). | 12-09-2010 |
20110284080 | Photovoltaic Cell With Silole-Containing Polymer - Photovoltaic cells with silole-containing polymers, as well as related systems, methods and components are disclosed. | 11-24-2011 |
20110290324 | Photovoltaic Cell With Thiazole-Containing Polymer - Photovoltaic cells with thiazole-containing polymers, as well as related components, systems, and methods, are disclosed. | 12-01-2011 |
20120186652 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, field effect transistors, and photodetectors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 07-26-2012 |
20120187385 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain oligomeric and polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide high power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 07-26-2012 |
20130069018 | SEMICONDUCTOR NANOCRYSTALS AND METHODS OF PREPARATION - A method for preparing semiconductor nanocrystals comprises reacting cation precursors and anion precursors in a reaction mixture including one or more acids, one or more phenol compounds, and a solvent to produce semiconductor nanocrystals having a predetermined composition. A method for forming a coating on at least a portion of a population of semiconductor nanocrystals is also disclosed. The method comprises forming a first mixture including a population of semiconductor nanocrystals, one or more amine compounds, and a first solvent; adding cation precursors and anion precursors to the first mixture at a temperature sufficient for growing a semiconductor material on at least a portion of an outer surface of at least a portion of the population of semiconductor nanocrystals; and initiating addition of one or more acids to the first mixture after addition of the cation and anion precursors is initiated. Semiconductor nanocrystals and populations thereof are also disclosed. | 03-21-2013 |
20130098448 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 04-25-2013 |
20130200354 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 08-08-2013 |
20130200355 | Conjugated Polymers and Their Use in Optoelectronic Devices - Disclosed are certain polymeric compounds and their use as organic semiconductors in organic and hybrid optical, optoelectronic, and/or electronic devices such as photovoltaic cells, light emitting diodes, light emitting transistors, and field effect transistors. The disclosed compounds can provide improved device performance, for example, as measured by power conversion efficiency, fill factor, open circuit voltage, field-effect mobility, on/off current ratios, and/or air stability when used in photovoltaic cells or transistors. The disclosed compounds can have good solubility in common solvents enabling device fabrication via solution processes. | 08-08-2013 |
20130271090 | DEVICES AND METHODS INCLUDING POLYACETYLENES - Embodiments described herein relate to compositions, devices, and methods for storage of energy (e.g., electrical energy). In some cases, devices including polyacetylene-containing polymers are provided. | 10-17-2013 |
20130273247 | SEMICONDUCTOR NANOCRYSTALS AND METHODS OF PREPARATION - A method for preparing semiconductor nanocrystals is disclosed. The method comprises adding a precursor mixture comprising one or more cation precursors, one or more anion precursors, and one or more amines to a ligand mixture including one or more acids, one or more phenol compounds, and a solvent to form a reaction mixture, wherein the molar ratio of (the one or more phenol compounds plus the one or more acids plus the one or more amine compounds) to the one or more cations initially included in the reaction mixture is greater than or equal to about 6, and heating the reaction mixture at a temperature and for a period of time sufficient to produce semiconductor nanocrystals having a predetermined composition. Methods for forming a buffer layer and/or an overcoating layer thereover are also disclosed. Semiconductor nanocrystals and compositions including semiconductor nanocrystals of the invention are also disclosed. In certain embodiments, a semiconductor nanocrystal includes one or more Group IIIA and one or more Group VA elements. | 10-17-2013 |
20140034129 | Photovoltaic Cell With Thiazole-Containing Polymer - Photovoltaic cells with thiazole-containing polymers, as well as related components, systems, and methods, are disclosed. | 02-06-2014 |
Patent application number | Description | Published |
20080213860 | Nicking Endonuclease Methods and Compositions - A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. | 09-04-2008 |
20080227133 | KpnI Restriction Endonucleases with Reduced Star Activity - Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity with KpnI are provided and reduced star activity demonstrated. | 09-18-2008 |
20080268507 | Recombinant Dna Nicking Endonuclease and Uses Thereof - Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where the mutation includes deletion of amino acid sequences at the C-terminal end of the protein. The nicking enzymes have been used for a number of purposes including: amplifying DNA from as few cells as can be found in a single bacterial colony in the presence of a strand displacing polymerase; and for removing genomic DNA in a biological preparation where it is deemed to be a contaminant. | 10-30-2008 |
20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
20090029418 | METHOD FOR CLONING AND EXPRESSION OF STUI RESTRICTION ENDONUCLEASE AND STUI METHYLASE IN E. COLI - The present invention relates to compositions including: (1) isolated DNA encoding the Stul restriction endonuclease and isolated DNA encoding cognate and non-cognate methylase; (2) vectors and cells containing the isolated DNA; and (3) methods for producing the Stul restriction endonuclease. | 01-29-2009 |
20090280528 | Method for Cloning and Expression of NruI Restriction Endonuclease - Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes. | 11-12-2009 |
20110076720 | NICKING ENDONUCLEASE METHODS AND COMPOSITIONS - A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. | 03-31-2011 |
20110151450 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-23-2011 |
20120088237 | Engineering a Novel Methylation-Specific Restriction Endonuclease - A restriction endonuclease is provided that has been engineered to have a cleavage specificity for a DNA recognition sequence containing a modified nucleotide. Methods for engineering enzymes to cleave DNA containing modified nucleotides at specific sequences are provided. | 04-12-2012 |
20120301881 | Compositions, Methods and Related Uses for Cleaving Modified DNA - Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3′ of the recognition site to produce a cleavage fragment with a 1-3 base overhang. | 11-29-2012 |
20130115676 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115677 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115678 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115679 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115680 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115681 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130122568 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-16-2013 |
20130130293 | Method for Reducing Star Activity in Restriction Endonucleases - Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity with KpnI are provided and reduced star activity demonstrated. | 05-23-2013 |
20130130935 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-23-2013 |
20130190209 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 07-25-2013 |
20140127678 | Mapping Cytosine Modifications - Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided. | 05-08-2014 |
20140154676 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154778 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154779 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154780 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |