Patent application number | Description | Published |
20100280032 | METHOD FOR TREATING INFLAMMATORY DISORDERS - The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof. | 11-04-2010 |
20100298331 | TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS - The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound. | 11-25-2010 |
20110319447 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 12-29-2011 |
20120122869 | TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 05-17-2012 |
20120202813 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 08-09-2012 |
20130072461 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 03-21-2013 |
20130109045 | METHODS OF IDENTIFYING HSP90 INHIBITORS WITH LESS OCULAR TOXICITY | 05-02-2013 |
20130296378 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 11-07-2013 |
20130345219 | TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS - The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound. | 12-26-2013 |
20140127740 | METHODS OF IDENTIFYING HSP90 INHIBITORS WITH LESS OCULAR TOXICITY - Provided is a method of identifying Hsp90 inhibitors with substantially less ocular toxicity or with substantially improved ocular toxicity profile. The method comprises measuring the respective concentrations of an Hsp90 inhibitor in the retina and plasma at certain time points following the administration of the Hsp90 inhibitor in a subject, and determining the concentration ratio of the Hsp90 inhibitor between retina and plasma, where a certain ratio is indicative that the Hsp90 inhibitor has substantially less ocular toxicity. The method also includes identifying an Hsp90 inhibitor with substantially less ocular toxicity, or with a substantially improved ocular toxicity profile, by determining the elimination rate of the Hsp90 inhibitor from the retina following administration of the Hsp90 inhibitor, where a certain elimination rate is indicative that the Hsp90 inhibitor will induce substantially less ocular toxicity. | 05-08-2014 |
20140141511 | METHOD FOR TREATING INFLAMMATORY DISORDERS - The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof. | 05-22-2014 |
20140371222 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 12-18-2014 |
20150183771 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 07-02-2015 |
20150266858 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 09-24-2015 |
Patent application number | Description | Published |
20100151831 | VISUAL VOICEMAIL NETWORK ARCHITECTURE - A system may include a load balancer that includes a receiver configured to receive a first notification of voicemail message information associated with a voicemail mailbox. The system may also include a group of servers and each of the group of servers may include a receiver and a transmitter. The receiver may be configured to receive the first notification of the voicemail message information from the load balancer, and the transmitter may be configured to send a second notification of the voicemail message information to a communication device associated with the voicemail mailbox, wherein the second notification causes the communication device to determine whether to request a list of voicemail messages. The load balancer may also include a processor to select a first one of the plurality of servers and a transmitter to send the first notification to the first one of the plurality of servers. | 06-17-2010 |
20110099488 | METHOD AND APPARATUS FOR PRESENTING VIDEO ASSETS - An approach is provided for presenting video assets. An asset manager determines a plurality of factors for positioning of video assets represented on a graphical user interface. The asset manager then determines weighting of the factors using one or more rules that are based on a search operation or a browse operation relating to the assets. From the determined plurality of factors and weighting of the factors, the asset manager computes a score for ranking of a particular one of the assets with respect to the positioning of other ones of the assets. | 04-28-2011 |
20110131594 | BOOSTING FACTOR FOR TELEVISION CONTENT - A method includes receiving viewership data associated with television contents; calculating one or more local boosting factors and a national boosting factor for each of the television contents based on the viewership data; applying boosting factor assignment heuristics to the one or more local and national boosting factors for each of the television contents; selecting one or more boosting factors based the applying of the boosting factor assignment heuristics for each of the television contents; and publishing the one or more boosting factors to one or more television distribution sites for each of the television contents. | 06-02-2011 |
20110238626 | AUTOMATIC USER DEVICE BACKUP - A user device connects to a global server via a public network and to a local server via a private network. The user device is configured to store information and preferences, where the preferences include information regarding a type of backup permitted by a user of the user device; determine that the preferences permit a local backup to the local server; determine whether a connection, to the local server, can be established, via the private network, based on the determination that the preferences permit the local backup; send at least some of the information to the local server and via the connection through the private network, when the connection to the local server can be established; and send, the at least some of the information to the local server, via the global server and the public network, when the connection to the local server cannot be established. | 09-29-2011 |
Patent application number | Description | Published |
20120117599 | THUMBNAIL PUBLICATION - A video service provider system may include one or more devices. The one or more device may receive thumbnails of programs that are currently airing on a group of television channels and match the received thumbnails with metadata. The metadata may include information relating to at least one of the television channels or the programs. The one or more devices may further provide, to a remote device, a set of thumbnails, of the captured thumbnails, and the metadata matching the set of thumbnails. The remote device may make the set of thumbnails and the metadata available to a user. | 05-10-2012 |
20120159543 | AUTOMATED QUERY GENERATION FOR TELEVISON CONTENT SEARCHING - A system is configured to receive a portion of a word; retrieve a group of words matching the portion of the word; retrieve information associated with a set of words in the group, where the information, for a particular one of the words, indicates a measure of popularity of the particular word, geographic location information associated with the particular word, time information associated with the particular word, or user preference information associated with the particular word; rank the set of words based on the information; present a list of words from the set of words for display based on the ranking; receive selection of a word from the list of words; perform a search for television content based on the selected word to identify a group of television content; receive selection of television content from the group of television content; and present the selected television content for display. | 06-21-2012 |
20130073574 | RULE-BASED METADATA TRANSFORMATION AND AGGREGATION FOR PROGRAMS - A method and devices for obtaining metadata associated with programs from multiple metadata sources. Title metadata is compared to determine if any title metadata match. Transformation rules are applied to the title metadata when title metadata does not match with other title metadata. The transformation rules transform the title metadata into a common format. The title metadata is compared after transformation to determine whether the title metadata matches other title metadata. Title metadata that matches other title metadata, the metadata associated with a program is aggregated. | 03-21-2013 |
20140123180 | Methods and Systems for Facilitating Remote Control of a Television by a Support Technician - An exemplary method includes a remote support management system 1) receiving a television support request from a user of a television, 2) generating, in response to the television support request, a ticket identifier associated with the television support request, and 3) facilitating, in accordance with the ticket identifier, remote control of the television by a support technician by way of a computing device associated with the support technician. Corresponding methods and systems are also disclosed. | 05-01-2014 |
20140289773 | THUMBNAIL PUBLICATION - A video service provider system may include one or more devices. The one or more device may receive thumbnails of programs that are currently airing on a group of television channels and match the received thumbnails with metadata. The metadata may include information relating to at least one of the television channels or the programs. The one or more devices may further provide, to a remote device, a set of thumbnails, of the captured thumbnails, and the metadata matching the set of thumbnails. The remote device may make the set of thumbnails and the metadata available to a user. | 09-25-2014 |
Patent application number | Description | Published |
20090033442 | NON-COPLANAR HIGH-SPEED INTERCONNECTS - In one example embodiment, a high-speed package includes first and second layers and a multi-channel non-coplanar interconnect. The first layer includes first and second sets of coplanar transmission lines. The second layer includes third and fourth sets of coplanar transmission lines. The multi-channel non-coplanar interconnect includes first and second channels. The first channel connects the first set of transmission lines to the third set of transmission lines. The second channel connects the second set of transmission lines to the fourth set of transmission lines. | 02-05-2009 |
20090160583 | HYBRID SURFACE MOUNTABLE PACKAGES FOR VERY HIGH SPEED INTEGRATED CIRCUITS - In one example, a hybrid surface mountable package includes a housing at least partially defining a sealed cavity, two microwave integrated circuits (MIC) chips positioned inside the sealed cavity, and a very-high-speed interconnect connecting the two MIC chips to each other. The very-high-speed interconnect includes strong coupling co-planar waveguide (CPWG) transmission lines. | 06-25-2009 |
20090267712 | FEED THRU WITH FLIPPED SIGNAL PLANE USING GUIDED VIAS - An embodiment of the invention includes a high speed feed thru connecting a first circuit outside a housing to a second circuit inside the housing. The first circuit includes a first high speed integrated circuit chip and the second circuit includes a second high speed integrated circuit chip or optoelectronic device. The high speed feed thru includes an inside coplanar structure positioned at least partially inside the housing, the inside coplanar structure connected to the second circuit. The high speed feed thru also includes an outside coplanar structure positioned at least partially outside the housing, the outside coplanar structure connected to the first circuit. A material separates the inside coplanar structure and the outside coplanar structure. At least one guided via extends through the material, connecting the inside coplanar structure and the outside coplanar structure. | 10-29-2009 |
20100329666 | THERMAL CHIRP COMPENSATION IN A CHIRP MANAGED LASER - Thermal chirp compensation in a chirp managed laser. In one example embodiment, a method for thermal chirp compensation in a chirp managed laser (CML) includes several acts. First, a first bias condition and temperature is selected. Next, a first thermal chirp compensation signal is generated. Then, the laser is driven by biasing a first input drive signal with the first thermal chirp compensation signal. Next, a second bias condition and temperature is selected. Then, a second thermal chirp compensation signal is generated. Finally, the laser is driven by biasing a second input drive signal with the second thermal chirp compensation signal. | 12-30-2010 |
20120032752 | VERTICAL QUASI-CPWG TRANSMISSION LINES - In one example embodiment, a coplanar waveguide signal transition element transitions high-speed signals between vertically stacked coplanar waveguide transmission lines. The signal transition element comprises one or more dielectric layers and a plurality of electrically conductive vias extending through at least a portion of the one or more dielectric layers. The vias include one or more signal vias and one or more ground vias that are configured to transition signals between the vertically stacked coplanar waveguide transmission lines. The signal transition element also comprises a ground plane disposed within the one or more dielectric layers and electrically coupled to the one or more ground vias. The ground plane has one or more openings through which the one or more signal vias respectively pass. | 02-09-2012 |
20120251130 | THERMAL CHIRP COMPENSATION IN A CHIRP MANAGED LASER - Thermal chirp compensation in a chirp managed laser. In one example embodiment, a laser package including a laser and an optical spectrum reshaper configured to convert frequency modulated optical signals from the laser into an amplitude modulated optical signals is provided. A thermal chirp compensation device is in communication with the laser package and a laser driver. The thermal chirp compensation device includes means for generating bias condition and temperature specific thermal chirp compensation signals that each corresponds to a predetermined level of thermal chirp that is induced in the laser by operating the laser at a particular bias condition and temperature. | 10-04-2012 |
Patent application number | Description | Published |
20090100536 | Transgenic plants with enhanced agronomic traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 04-16-2009 |
20110258734 | GENE SEQUENCES AND USES THEREOF IN PLANTS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 10-20-2011 |
20130064823 | COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES - The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof. | 03-14-2013 |
20130074202 | GENE SEQUENCES AND USES THEREOF IN PLANTS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 03-21-2013 |
20130245233 | Multispecific Molecules - The present invention is directed to multi-specific/multivalent molecules of novel formats. The molecules with the formats of the present invention have desired yield and thermostability. The present invention also includes methods of producing and using the molecules described herein. | 09-19-2013 |
20140050725 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 02-20-2014 |
20150030617 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 01-29-2015 |
Patent application number | Description | Published |
20100184145 | ANTIBODY-BASED THERAPEUTICS WITH ENHANCED ADCC ACTIVITY - Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases. | 07-22-2010 |
20110300120 | OLIGOSACCHARIDE-PROTEIN CONJUGATES - Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate. | 12-08-2011 |
20140294867 | SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION THROUGH GLYCOENGINEERING - The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided. | 10-02-2014 |
20150175643 | OLIGOSACCHARIDE-PROTEIN CONJUGATES - Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate. | 06-25-2015 |
Patent application number | Description | Published |
20100276941 | SYSTEM AND METHOD FOR UMBRELLA POWER GENERATION - In accordance with an embodiment of the invention, there is provided a system for power generation from a fluid, such as air or water. The system comprises a rail tether, and a working umbrella movably mounted to the rail tether such that the working umbrella is powered by the fluid in a first direction along the rail tether during a working stroke of the working umbrella. A working tether couples the working umbrella to a generator during at least the working stroke of the working umbrella, and a motor is coupled to the working umbrella during at least a recovery stroke of the working umbrella, the recovery stroke being in an opposite direction to the first direction along the rail tether. | 11-04-2010 |
20120250022 | Hand-Held Color Measurement Device - A hand-held color measurement device is provided that includes a housing with an opto-measurement unit. The latter includes an optics array for receiving measurement light and a sensor array which is exposed to the measurement light, converts the measurement light into electrical measurement signals, and processes them to form digital measurement data. The measurement unit (M) consists of an aspherical input lens (L | 10-04-2012 |
20120253727 | Color Measuring Device Calibration - In a calibrating method for a filter color measuring device that includes at least three color channels, a calibration matrix for transforming output signals of the color channels into tristimulus color values is formed. The calibration is performed spectrally, wherein the spectral sensitivities of the color channels of the color measuring device and the spectral emission properties of typical light sources are measured and stored, and the calibration matrix is calculated from the spectral sensitivities and the spectral emission properties of the light sources and the spectral evaluation functions of the standard observer, e.g., according to CIE 1931. | 10-04-2012 |
20150241632 | SYSTEMS AND METHODS FOR MULTIPLE-BEAM LASER ARRANGEMENTS WITH VARIABLE BEAM PARAMETER PRODUCT - In various embodiments, a beam-parameter adjustment system and focusing system alters a spatial power distribution of a plurality of radiation beams before the beams are coupled into an optical fiber. | 08-27-2015 |
20150251273 | POLARIZATION-ADJUSTED BEAM OPERATION FOR MATERIALS PROCESSING - Systems and techniques for optimizing the operation of a beam emitter during material processing maintain an optimal polarization of the beam with respect to the material throughout processing—e.g., even as the beam path varies or the nature or thickness of the material changes. | 09-10-2015 |
20150331205 | SYSTEMS AND METHODS FOR LASER SYSTEMS WITH VARIABLE BEAM PARAMETER PRODUCT - In various embodiments, a beam-parameter adjustment system and focusing system alters a spatial power distribution of a radiation beams before the beam is coupled into an optical fiber or delivered to a workpiece. | 11-19-2015 |
20150331245 | WAVELENGTH BEAM COMBINING LASER SYSTEMS WITH MICRO-OPTICS - In various embodiments, wavelength beam combining systems feature multiple beam emitters each emitting an individual beam, as well as multiple micro-optics arrangements each disposed optically downstream from a beam emitter to intercept the beam emitted thereby and direct the beam toward a dispersive element for combination into a multi-wavelength output beam. | 11-19-2015 |
20150364900 | STABILIZATION OF WAVELENGTH BEAM COMBINING LASER SYSTEMS IN THE NON-WAVELENGTH BEAM COMBINING DIRECTION - In various embodiments, wavelength beam combining laser systems incorporate optics having optical power along the non-WBC direction (and/or the slow-diverging axis) of the combined multi-wavelength beam proximate to or combined with the partially reflective output coupler in order to correct pointing variation in the non-WBC direction (and/or the slow-diverging axis). | 12-17-2015 |
Patent application number | Description | Published |
20120088766 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES - The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof. | 04-12-2012 |
20120094999 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS - The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate epidermal growth factor receptor (EGFR), including Her-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions. | 04-19-2012 |
20130184287 | INDAZOLE COMPOUNDS AND THEIR USES - The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof. | 07-18-2013 |
20150094315 | FUSED 2-AMINOTHIAZOLE COMPOUNDS - The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof. | 04-02-2015 |
Patent application number | Description | Published |
20140046796 | Digital Commerce Systems and Methods Facilitating Charitable Giving - The invention provides, in some aspects, a digital commerce system that includes first and second digital data devices that are coupled with a server digital data processor via a network supporting at least intermittent communications therebetween. The server digital data processor is responsive to requests by owners/operators of those digital data devices for (i) selling or otherwise transferring ownership of or other rights in an object from an owner/operator of the first digital data device to an owner/operator of the second digital data device, and (ii) transferring any of credits and/or monetary funds (collectively, “funds”) from an owner/operator of the second digital data device to a charity designated by the owner/operator of the first digital data device. | 02-13-2014 |
20140052558 | METHODS AND APPARATUS FOR SHARING DIGITAL BOOKS AND OTHER DIGITAL MEDIA OBJECTS - The invention provides in some aspects a digital data system that includes a first digital data device that, in order to transfer a digital media object to a second digital data device, transfers to that second digital data device a virtual machine embodying that digital media object. Those digital data devices may be, according to aspects of the invention, any of mainframe computers, minicomputers, workstations, desktop computers, portable computers, tablet computers, smart phones, personal digital assistants, eReaders, video consoles, movie players and other dedicated digital data devices. And, according to further aspects of the invention, the digital media object comprises a creative work, such as, by way of nonlimiting example, a song, video, movie, book, story, article, document, still image, video game, software, or combination thereof | 02-20-2014 |
Patent application number | Description | Published |
20090269410 | Inhibition of Neovascularization by Cerium Oxide Nanoparticles - The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject. | 10-29-2009 |
20110111007 | INHIBITION OF RETINAL CELL DEGENERATION OR NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES - The presently claimed and disclosed inventive concept(s) provides methods for reducing, reversing or inhibiting retinal cell degeneration, or neovascularization in tissues of a mammalian subject having a pathological condition involving neovascularization, by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the presently claimed and disclosed inventive concept(s) is useful, for example, for reducing, treating, reversing or inhibiting degeneration of retinal cells such as photoreceptor cells or neovascularization in ocular tissue such as the retina, macula or cornea; or other tissues such as, but not limited to, skin, synovial tissue, intestinal tissue, or bone. In addition, the method of the presently claimed and disclosed inventive concept(s) is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the presently claimed and disclosed inventive concept(s) is directed to using compositions containing nanoceria particles to reduce, treat, reverse or inhibit angiogenesis in a mammalian subject. | 05-12-2011 |
20120093931 | Inhibition of Neovascularization by Cerium Oxide Nanoparticles - The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject. | 04-19-2012 |
Patent application number | Description | Published |
20100047257 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 02-25-2010 |
20130302316 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 11-14-2013 |
20150274824 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferrentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 10-01-2015 |
Patent application number | Description | Published |
20090258352 | Pin1 as a marker for abnormal cell growth - Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels. | 10-15-2009 |
20140242100 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES - The present invention features methods and compositions for the generation of conformation-specific antibodies. | 08-28-2014 |
20150038683 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES - The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof. | 02-05-2015 |
20150044278 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS - The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors. | 02-12-2015 |
20150133442 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 - The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels. | 05-14-2015 |
Patent application number | Description | Published |
20110140075 | LIGHT-EMITTING DEVICE INCLUDING QUANTUM DOTS - A light emitting device including an emissive material comprising quantum dots is disclosed. In one embodiment, the device includes a cathode, a layer comprising a material capable of transporting and injection electrons comprising an inorganic material, an emissive layer comprising quantum dots, a layer comprising a material capable of transporting holes, a layer comprising a hole injection material, and an anode. In certain embodiments, the hole injection material can be a p-type doped hole transport material. In certain preferred embodiments, quantum dots comprise semiconductor nanocrystals. In another aspect of the invention, there is provided a light emitting device wherein the device has an initial turn-on voltage that is not greater than 1240/λ, wherein λ represents the wavelength (nm) of light emitted by the emissive layer. Other light emitting devices and a method are disclosed. | 06-16-2011 |
20120292594 | DEVICE INCLUDING QUANTUM DOTS AND METHOD FOR MAKING SAME - A device comprises an anode; a cathode; a layer therebetween comprising quantum dots; and a first layer comprising a material capable of transporting and injecting electrons in, or forming, contact with the cathode, the material comprising nanoparticles of an inorganic semiconductor material. In one embodiment of the device, quantum dots comprise a core comprising a first semiconductor material that confines holes better than electrons in the core and an outer shell comprising a second semiconductor material that is permeable to electrons. In another embodiment of the device, the nanoparticles comprise n-doped inorganic semiconductor material, and a second layer comprising a material capable of transporting electrons is disposed between the layer including quantum dots and the first layer, wherein the second layer has a lower electron conductivity than the first. In a further embodiment of the device, the first layer is UV treated. A method and other embodiments are also disclosed. | 11-22-2012 |
20140054540 | DEVICE INCLUDING SEMICONDUCTOR NANOCRYSTALS & METHOD - A method of making a device comprising semiconductor nanocrystals comprises forming a first layer capable of transporting charge over a first electrode, wherein forming the first layer comprises disposing a metal layer over the first electrode and oxidizing at least the surface of the metal layer opposite the first electrode to form a metal oxide, disposing a layer comprising semiconductor nanocrystals over the oxidized metal surface, and disposing a second electrode over the layer comprising semiconductor nanocrystals. A device comprises a layer comprising semiconductor nanocrystals disposed between a first electrode and a second electrode, and a first layer capable of transporting charge disposed between the layer comprising semiconductor nanocrystals one of the electrodes, wherein the first layer capable of transporting charge comprises a metal layer wherein at least the surface of the metal layer facing the layer comprising semiconductor nanocrystals is oxidized prior to disposing semiconductor nanocrystals thereover. | 02-27-2014 |
Patent application number | Description | Published |
20140027713 | DEVICE INCLUDING QUANTUM DOTS - A method for making a device, the method comprising: depositing a layer comprising quantum dots over a first electrode, the quantum dots including ligands attached to the outer surfaces thereof; treating the surface of the deposited layer comprising quantum dots to remove the exposed ligands; and forming a device layer thereover. Also disclosed is a device made in accordance with the disclosed method. Another aspect of the invention relates to a device comprising a first electrode and a second electrode, and a layer comprising quantum dots between the two electrodes, the layer comprising quantum dots deposited from a dispersion that have been treated to remove exposed ligands after formation of the layer in the device. Another aspect of the invention relates to a device comprising a first electrode and a second electrode, a layer comprising a first inorganic semiconductor material disposed between the first and second electrodes, and a plurality of quantum dots disposed between the first and second electrodes, the outer surface of the quantum dots comprising a second inorganic semiconductor material, wherein the composition of the first inorganic semiconductor material and the second inorganic semiconductor material is the same (without regard to any ligands on the outer surface of the quantum dot). | 01-30-2014 |
20150179987 | NOVEL SUBSTRATE AND PROCESS FOR HIGH EFFICIENCY OLED DEVICES - A method of fabricating a substrate for an organic light emitting device (OLED), by applying a volume-reducing substrate material onto a mold with topographical features that generates a smooth but non-flat surface on both sides of the substrate which can enhance light extraction of OLEDs that are built on top of the substrate. The resulting substrate includes surface features on a first substrate surface complementary to the surface features of a mold, such as spherical lens features, and surface features on a second substrate surface, such as dimple features, complementary to the curvature of the spherical lens features on the first substrate surface. | 06-25-2015 |
Patent application number | Description | Published |
20090057545 | Downhole Tools with Solid-State Neutron Monitors - A nuclear tool includes a tool housing; a neutron generator disposed in the tool housing; and a solid-state neutron monitor disposed proximate the neutron generator for monitoring the output of the neutron generator. A method for constructing a nuclear tool includes disposing a neutron generator in a tool housing; and disposing a solid-state neutron monitor proximate the neutron generator for monitoring the output of the neutron generator. A method for logging a formation includes disposing a nuclear tool in a wellbore penetrating the formation, wherein the nuclear tool comprises a neutron generator and a solid-state neutron monitor disposed proximate the neutron generator; generating neutrons from the neutron generator; monitoring neutrons generated by the neutron generator using the solid-state neutron monitor; detecting signals generated from the neutrons traveling in the formation; and correcting the detected signals, based on signal strength detected by the solid-state neutron monitor, to produce corrected signals. | 03-05-2009 |
20120175510 | FLUIDIC DENSITY MEASUREMENTS BASED ON BETA PARTICLES DETECTION - Devices, methods and related systems are described for measuring a property of a fluid including density in a subterranean environment. A device includes a pressure housing having one or more window formed in the pressure housing, and a flow device arranged in the pressure housing for the fluid to flow through the flow device. Further, a radiation source mounted within the pressure housing approximate a first source window configured to generate particles into the fluid. A detector supported by the pressure housing and positioned approximate a first detector window of the one or more window, the first detector window located between the detector and the flow device. The detector can be a solid state beta particle detector with a wide band gap such as the diamond detector, and the radiation source can be a beta particle source such as a strontium 90 source. | 07-12-2012 |
20130170592 | DEVICE AND METHOD FOR ION GENERATION - Illustrative embodiments of the present invention are directed to devices and methods for ion generation. One such device includes a substrate. The substrate is disposed within a housing that is configured to contain a gas. The substrate includes an interior surface that at least partially defines an interior volume. The substrate also includes a number of channels with walls. Nano-tips are disposed on the walls of the channels. | 07-04-2013 |
20130214145 | Gamma-Ray Detectors For Downhole Applications - Methods and related systems are described for gamma-ray detection. A gamma-ray detector is made depending on its properties and how those properties are affected by the data analysis. Desirable properties for a downhole detector include; high temperature operation, reliable/robust packaging, good resolution, high countrate capability, high density, high Z, low radioactive background, low neutron cross-section, high light output, single decay time, efficiency, linearity, size availability, etc. Since no single detector has the optimum of all these properties, a downhole tool design preferably picks the best combination of these in existing detectors, which will optimize the performance of the measurement in the required environment and live with the remaining non-optimum properties. A preferable detector choice is one where the required measurement precision (logging speed) is obtained for all of the required inelastic elements and/or minimization of unwanted background signals that complicate the data analysis. | 08-22-2013 |
20130287174 | DEVICE AND METHOD FOR MONITORING X-RAY GENERATION - Illustrative embodiments of the present disclosure are directed to devices and methods for X-ray monitoring. Various embodiments of the present disclosure use a target that incorporates a monitor layer. The monitor layer is disposed adjacent to a target layer so that electrons that pass through the target layer enter the monitor layer. As electrons enter the monitor layer, electrical charge is generated within the monitor layer. This electrical charge is measured and used to determine a characteristic of the X-ray generation within the target layer. | 10-31-2013 |
20140117246 | APPARATUS AND METHOD FOR DETECTING RADIATION - Apparatus and method for detecting radiation-of-interest, such as neutron radiation, employs a gas chamber, a gas that responds to ionizing particles by producing electrons and ions, a cathode that attracts ions, and a supporting layer with a conductive pathway. The conductive pathway collects electrons and responds to electrons that drift towards the conductive pathway by inducing production of further electrons and ions within the gas. The electrons that are collected at the conductive pathway and/or the ions that drift away from the conductive pathway will induce an electrical signal, which can be used to detect the radiation-of-interest. | 05-01-2014 |
20150076337 | Gamma-Ray Detectors For Downhole Applications - Methods and related systems are described for gamma-ray detection. A gamma-ray detector is made depending on its properties and how those properties are affected by the data analysis. Desirable properties for a downhole detector include; high temperature operation, reliable/robust packaging, good resolution, high countrate capability, high density, high Z, low radioactive background, low neutron cross-section, high light output, single decay time, efficiency, linearity, size availability, etc. Since no single detector has the optimum of all these properties, a downhole tool design preferably picks the best combination of these in existing detectors, which will optimize the performance of the measurement in the required environment and live with the remaining non-optimum properties. A preferable detector choice is one where the required measurement precision (logging speed) is obtained for all of the required inelastic elements and/or minimization of unwanted background signals that complicate the data analysis. | 03-19-2015 |
20150241577 | Combined Epithermal And Thermal Neutron Detector And Its Application To Well Logging Instruments - A combined thermal neutron and epithermal neutron radiation detector includes a plurality of neutron detecting elements arranged such that a first set of the detecting elements is disposed closer to a source of neutron flux scatted from a material or formation to be analyzed than a second set of detecting elements. The neutron detecting elements have a material therein susceptible to capture of thermal neutrons for detection. Signal outputs of the first set of are interconnected and signal outputs of the second set are separately interconnected to provide a signal output corresponding to each of thermal neutron flux and epithermal neutron flux entering the detector. | 08-27-2015 |