Patent application number | Description | Published |
20140342003 | ENZYMATIC SYNTHESIS OF POLY(AMINE-CO-ESTERS) AND METHODS OF USE THEREOF FOR GENE DELIVERY - Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition. | 11-20-2014 |
20150073041 | FORMULATIONS FOR TARGETED RELEASE OF AGENTS TO LOW PH TISSUE ENVIRONMENTS OR CELLULAR COMPARTMENTS AND METHODS OF USE THEREOF - Polyamine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents. | 03-12-2015 |
Patent application number | Description | Published |
20090172696 | SERVICE-BASED CONTENT MANAGEMENT - The present invention leverages and modifies service-oriented architecture and concepts to provide an enterprise content management (ECM) system as a service. This allows organizations (potential customers) to be provided with a service as opposed to purchasing a software product. In the present invention, it is disclosed how to build a reusable enterprise content management ECM as an asset being a brick for business service using SOA methodology. To achieve these goals, this invention has, among other things/components: (1) abstracts the generic portion of individual ECM; (2) introduces a new unique component to allow configuring the data modeling part and workflow of each individual ECM; (3) provides a common UI for the content edit and view; and (4) provides a plug-in component for bulk content processing. | 07-02-2009 |
20090276519 | Method and System for Achieving Better Efficiency in a Client Grid Using Node Resource Usage and Tracking - A system, method and computer program product for distributing task assignments on a computer network comprising a client grid having at least one server coupled to at least one client node and a plurality of client computers coupled to the client node through a plurality of monitoring agents. Each monitoring agent collects data regarding the resources a particular client computer makes available to the grid and transmits the data to the grid server when the client computer requests a grid task. The system generates a resource probability distribution based on the historical computing resource data and employs a scheduling algorithm to distribute grid tasks to the client computers using at least the probability distribution. | 11-05-2009 |
20110004499 | Traceability Management for Aligning Solution Artifacts With Business Goals in a Service Oriented Architecture Environment - A method and system for providing traceability management to align IT solution artifacts with business goals in a service oriented architecture environment. A pattern matching framework is provided for generating patterns and transformation enablers for architectural artifacts based on specific business requirements. Patterns that are applicable to a selected set of artifacts or model are provided to an architect, who may then select a particular subset of the patterns to apply to the set of artifacts or model in the SOA solution design to speed up and simplify the design process. Providing applicable or candidate patterns for selection to the architect in the views reduces the possible ambiguity in architectural artifact-pattern matching and selection. These solution patterns may be used as a guide when configuring and linking architectural artifacts and models. | 01-06-2011 |
20110288902 | COLLABORATION BASED CAPACITY PLANNING IN A MODULAR BUSINESS SETTING - A computer implemented method, system, and/or computer program product collaboratively reallocate resources across business modules. A collaboration vector, which describes primary and second abilities for each of multiple resources, is defined. A decision matrix is created from multiple collaboration vectors, and a pipeline for transferring the multiple resources among multiple business modules is defined based on the decision matrix. A recurring time interval to measure an effectiveness of the multiple business modules is defined, and the multiple resources are reallocated according to a measured effectiveness of the multiple business modules. The collaborative matrix is optimized to reflect reallocation of the multiple resources. | 11-24-2011 |
20120035972 | Optimizing Resources Allocation for Global Service Delivery - Techniques for optimizing resource allocation are provided. The techniques include identifying one or more communication needs for each of one or more communications needed for execution of a project, identifying one or more members of each of the one or more communications and member information for each of the one or more members, using the one or more communication needs and member information to estimate one or more communication costs for each of the one or more communications needed for execution of the project, and comparing the one or more communication costs for each of the one or more communications to optimize resource allocation for executing the project. | 02-09-2012 |
20120278267 | METHODS AND ARRANGEMENTS FOR DYNAMICALLY GENERATING ESTIMATION TRENDLINES - Methods and arrangements for dynamic trendline generation. Input data are assimilated at a capture timepoint from an estimation tool. The input data are filtered, and an estimation-centric map is created from the filtered data ; this creating of a map includes generating an estimation data tree. A trendline is dynamically generated responsive to a request, wherein this generating of a trendline includes applying the estimation data tree to the input data. The dynamically generated trendline is supplied to the estimation tool. | 11-01-2012 |
20130030857 | METHODS AND SYSTEMS FOR DYNAMICALLY FACILITATING PROJECT ASSEMBLY - Methods and arrangements for dynamically facilitating project assembly. A project plan with a chosen set of plan components is submitted and a cloud portal is queried for information on chosen plan components. Information on the chosen plan components is received from the cloud portal. Plan recommendations are generated based on the received information, and a recommended plan is selected. | 01-31-2013 |
20130030858 | DYNAMICALLY FACILITATING PROJECT ASSEMBLY - Methods and arrangements for dynamically facilitating project assembly. A project plan with a chosen set of plan components is submitted and a cloud portal is queried for information on chosen plan components. Information on the chosen plan components is received from the cloud portal. Plan recommendations are generated based on the received information, and a recommended plan is selected. | 01-31-2013 |
20130061203 | Modeling Task-Site Allocation Networks - A method, an apparatus and an article of manufacture for modeling a task-site allocation. The method includes generating a task-site allocation network based on at least one site-task pair and at least one site-centric constraint of at least two sites, wherein generating a task-site allocation network comprises generating a task-specific constraints model based on task context information and generating a task-site pair that satisfies at least one constraint based on the task-specific constraints model, and determining a preferred allocation of task to site by comparing estimated task-site allocation cost between a single site allocation and a distributed site allocation among the at least two sites. | 03-07-2013 |
20130263150 | AUTOMATED ALLOCATION OF RESOURCES TO FUNCTIONAL AREAS OF AN ENTERPRISE ACTIVITY ENVIRONMENT - A computer implemented method, system and/or computer program product automatically allocates resources to functional areas of an enterprise activity environment. A skill level of a resource is determined for multiple functional areas. An affinity index is created and associated with each of the multiple functional areas, wherein the affinity index is based on a level of productivity drop of other resources in a specific functional area if the resource is assigned to another functional area. Expected resource and skill level requirements of a project are identified. The resource is automatically allocated to one or more functional areas based on the affinity index associated with a particular functional area in view of the expected resource and skill level requirements. | 10-03-2013 |
20140222488 | Quantifying the Quality of Trend Lines - Techniques, apparatus and articles of manufacture for quantifying the quality of trend lines. A method includes defining a collection of reference data sets derived from multiple historical projects in a similar subject area as the target project, defining one or more indicators of data set applicability to a target project estimation, said defining based on multiple characteristics of the target project, evaluating applicability of each of the reference data sets based on the one or more indicators, and identifying one or more of the reference data sets as applicable for use in the target project estimation. | 08-07-2014 |
20140222489 | Quantifying the Quality of Trend Lines - Apparatus and articles of manufacture for quantifying the quality of trend lines include defining a collection of reference data sets derived from multiple historical projects in a similar subject area as the target project, defining one or more indicators of data set applicability to a target project estimation, said defining based on multiple characteristics of the target project, evaluating applicability of each of the reference data sets based on the one or more indicators, and identifying one or more of the reference data sets as applicable for use in the target project estimation. | 08-07-2014 |
20140258977 | METHOD AND SYSTEM FOR SELECTING SOFTWARE COMPONENTS BASED ON A DEGREE OF COHERENCE - Disclosed is a novel system and method to select software components. A set of available software components are accessed. Next, one or more dimensions are defined. Each dimension is an attribute to the set of available software components. A set of coherence distances between each pair of the available software components in the set of available software components is calculated for each of the dimensions that have been defined. Each of the coherence distances are combined between each pair of the available software components that has been calculated in the set of the coherence distances into an overall coherence degree for each of the available software components. Using the overall coherence degree, one or more software components are selected to be included in a software bundle. | 09-11-2014 |
20140258980 | SYSTEM FOR SELECTING SOFTWARE COMPONENTS BASED ON A DEGREE OF COHERENCE - Disclosed is a novel system and method to select software components. A set of available software components are accessed. Next, one or more dimensions are defined. Each dimension is an attribute to the set of available software components. A set of coherence distances between each pair of the available software components in the set of available software components is calculated for each of the dimensions that have been defined. Each of the coherence distances are combined between each pair of the available software components that has been calculated in the set of the coherence distances into an overall coherence degree for each of the available software components. Using the overall coherence degree, one or more software components are selected to be included in a software bundle. | 09-11-2014 |
Patent application number | Description | Published |
20090129204 | Apparatus, Systems and Methods For Enhanced Multi-Carrier Based Underwater Acoustic Communications - Advantageous OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. In general, OFDM transmissions over UWA channels encounter frequency-dependent Doppler drifts that destroy the orthogonality among OFDM subcarriers. The disclosed apparatus, systems, and methods use a two-step approach to mitigate frequency-dependent Doppler drifts for zero-padded OFDM transmissions over fast-varying channels: (1) non-uniform Doppler compensation via resampling to convert a “wideband” problem into a “narrowband” problem; and (2) high-resolution uniform compensation on the residual Doppler. The disclosed apparatus, systems and methods are based on block-by-block processing and do not rely on channel dependence across OFDM blocks. Thus, the disclosed apparatus, systems and methods are advantageously applicable for fast-varying UWA channels. | 05-21-2009 |
20110013487 | APPARATUS, SYSTEMS AND METHODS FOR ENHANCED DETECTION, SYNCHRONIZATION AND ONLINE DOPPLER SCALE ESTIMATION FOR UNDERWATER ACOUSTIC COMMUNICATIONS - Advantageous online and/or real-time OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. The apparatus, systems and methods employ a receiver with a bank of parallel branches, with each branch having a self-correlator matched to a different waveform scaling factor. A detection is declared when any of the branches leads to a correlation metric larger than a pre-defined threshold. The branch with the largest metric yields a Doppler scale estimate and a coarse synchronization point. The proposed apparatus, systems and methods use one OFDM preamble, thereby avoiding the need to buffer the whole data packet before data demodulation and enabling online and/or real-time operation. Thus, the disclosed apparatus, systems and methods are advantageously applicable to UWA communications. | 01-20-2011 |
20110029845 | Apparatus, Systems and Methods Including Nonbinary Low Density Parity Check Coding For Enhanced Multicarrier Underwater Acoustic Communications - Advantageous underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. The apparatus, systems and methods employ nonbinary low density parity check (LDPC) codes that achieve excellent performance and match well with the underlying modulation. The nonbinary LDPC codes of the proposed apparatus, systems and methods are formed, at least in part, from a generator matrix that has a high density to reduce the peak-to-average-power ratio (PAPR) with minimal overhead. The disclosed apparatus, systems and methods employ nonbinary regular LDPC cycle codes if the constellation is large and nonbinary irregular LDPC codes if the constellation is small or moderate. The nonbinary irregular and regular LDPC codes enable: i) parallel processing in linear-time encoding; ii) parallel processing in sequential belief propagation decoding; and iii) considerable resource reduction on the code storage for encoding and decoding. | 02-03-2011 |