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| 20120202202 | METHODS FOR DETECTING RARE CIRCULATING CANCER CELLS USING DNA METHYLATION BIOMARKERS - Provided are new and improved methods for detecting circulating tumor cells and tumor cell DNA in patient blood or other biofluid samples. Particular aspects comprise three steps: DNA extraction from patient samples, DNA digestion with multiple selected methylation-sensitive enzymes, and target amplification by a conventional or a real-time PCR with specific probe and/or primers. Also provided are a total of 40 tumor-specific DNA methylation loci as biomarkers having substantial utility and specificity in major types of human malignancies including hematopoietic and solid tumors. | 08-09-2012 |
| 20140038194 | Method For Early Detection of Lung Cancer - The invention provides a blood-based noninvasive early lung cancer detection method, which investigates a panel of miRNA levels in a blood or plasma sample. The panel of miRNA includes miR-17, miR-21, miR-24, miR-106a, miR-125b, miR-128, miR-155, miR-182, miR-183, miR-197, miR-199b, miR-203, miR-205, miR-210, miR-221, and a combination thereof. Preferably, the panel of miRNA may include miR-21, miR-128, miR-155, miR-182, miR-183, and miR-197. The inventive method can not only detect stage I lung cancer patients with high accuracy, but also differentiate between all stages of lung cancer patients and lung cancer-free individuals, metastatic and non-metastatic lung cancer patients and monitor the significant changes of miRNA levels during chemotherapy. | 02-06-2014 |
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| 20140070078 | Optical Proximity Sensor With Ambient Light and Temperature Compensation - An electronic device may be provided with a proximity sensor. The proximity sensor may include a light source such as a light-emitting diode and a light detector such as a photodiode. The light-emitting diode may be driven with an alternating current drive signal so that alternating current light is produced. The alternating current light may reflect off of an external object and may be received by the photodiode. The photodiode may receive a direct current light signal associated with the presence of ambient light. The efficiency of the photodiode may be affected by the level of ambient light and the efficiency of the light-emitting diode may be affected by the temperature of the light-emitting diode. Ambient light correction circuitry and temperature correction circuitry may be used to ensure that proximity sensor readings are not adversely affected by changes in operating temperature and ambient lighting conditions. | 03-13-2014 |
| 20140132578 | Ambient Light Sensors with Infrared Compensation - An electronic device may have a display with a brightness that is adjusted based on ambient light data from one or more ambient light sensors. An ambient light sensor may include at least one silicon-based photosensor. The silicon-based photosensor may generate a corresponding raw sensor reading. Processing circuitry associated with the ambient light sensor may analyze the raw sensor reading to determine the type of light source that is present by comparing measurements from at least two different photosensors, by determining the color temperature of the light source, and/or by determining the modulation frequency of the light source. A compensation factor may then be selected by referring to a lookup table. The processing circuitry may compute a compensated sensor reading based on the raw sensor reading and the selected compensation factor. The brightness of the display may be adjusted based on the compensated sensor reading computed in this way. | 05-15-2014 |
| 20140166850 | Electronic Device With Display and Low-Noise Ambient Light Sensor - An electronic device may be provided that has a display. The display may produce stray light when producing images for a user. The electronic device may have an ambient light sensor for measuring ambient light levels. Ambient light data may be used in adjusting display brightness. The display may be periodically disabled to prevent the stray light from interfering with the ambient light sensor. An integrating analog-to-digital converter may be used in gathering sensor data from the ambient light sensor. Control circuitry may be configured to remove background signals from ambient light sensor data. The background signals may be associated with leakage current that arises due to offset voltages in an operational amplifier in the integrating analog-to-digital converter. The operational amplifier may have an analog autozeroing capability or control circuitry may be used to subtract background data from ambient light sensor data. | 06-19-2014 |
| 20140267202 | Ambient Light Sensors with Photodiode Leakage Current Compensation - An electronic device may have a display with a brightness that is adjusted based on data gathered from one or more ambient light sensors (ALSs). In one suitable arrangement, an ALS may include a photodiode, a temperature sensor, a scaler, an analog-to-digital converter (ADC), and a subtractor. The subtractor may have a first input coupled to the photodiode via the ADC, a second input coupled to the temperature sensor via the scaler, and an output on which a leakage-compensated sensor output is provided. In another suitable arrangement, the ALS may include first and second photodiodes, a light blocking layer formed over the second photodiode, a scaler, and a subtractor. The subtractor may have a first input coupled to the first photodiode, a second input coupled to the second photodiode via the scaler, and an output on which a leakage-compensated sensor output is provided. | 09-18-2014 |
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| 20110132220 | POLYMER PEN LITHOGRAPHY - The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes. | 06-09-2011 |
| 20110305996 | Beam Pen Lithography - The disclosure relates to methods of beam pen lithography using a tip array having a plurality of transparent, elastomeric, reversibly-deformable tips coated with a blocking layer and apertures defined in the blocking layer to expose tip ends of the tips in the array. The tip array can be used to perform a photolithography process in which the tips are illuminated with a radiation that is channeled through the tips and out the apertures to expose a photosensitive substrate. Also disclosed are tip arrays formed of polymers and gels, apparatus including the tip arrays and radiation sources, and related apparatus for selectively masking tips in the tip array from radiation emitted from the radiation source. | 12-15-2011 |
| 20120167262 | SILICON PEN NANOLITHOGRAPHY - Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface. | 06-28-2012 |
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| 20120315457 | FIBERGLASS COMPOSITES WITH IMPROVED FLAME RESISTANCE AND METHODS OF MAKING THE SAME - Fiberglass products with increased flame resistance are described. The products may include fiberglass-containing thermal insulation that include a plurality of glass fibers that are at least partially coated with a vermiculite-containing flame retardant. The products may further include fiberglass composites that are about 50 wt. % to about 98 wt. % glass fibers, about 2 wt. % to about 50 wt. % of a binder; and a flame retardant that includes vermiculite. Also described are methods of making fiberglass products with increased flame resistance. These methods may include the steps of contacting glass fibers and/or fiberglass composite with a flame retardant mixture that includes vermiculite. | 12-13-2012 |
| 20120315458 | FIBERGLASS COMPOSITES WITH IMPROVED FLAME RESISTANCE FROM PHOSPHOROUS-CONTAINING MATERIALS AND METHODS OF MAKING THE SAME - Fiberglass products with increased flame resistance are described. The products may include fiberglass-containing thermal insulation that include a plurality of glass fibers coated with a phosphorous-containing flame retardant. The flame retardant may include an organophosphorous compound having a substituted or unsubstituted organophosphorous group bonded to a substituted or unsubstituted amide group by a substituted or unsubstituted alkyl group. The fiberglass products may further include fiberglass composites that are about 50 wt. % to about 98 wt. % glass fibers, about 2 wt. % to about 50 wt. % of a binder; and a phosphorous-containing flame retardant. Also described are methods of making fiberglass products with increased flame resistance. These methods may include the steps of contacting glass fibers and/or fiberglass products with a flame retardant mixture that includes a phosphorous-containing compound. | 12-13-2012 |
| 20130045352 | NON-WOVEN FIRE BARRIER MAT - A burnthrough resistant non-woven mat is made of a glass fibers and includes a binder having a vinyl component and a strengthening component. The vinyl component may be, for example, ethylene vinyl chloride, and the strengthening component may be, for example, melamine formaldehyde. The burnthrough resistant non-woven mat may be used in conjunction with an insulation blanket, and may be especially suited to use in insulating aircraft. Methods of making the burnthrough resistant non-woven mat are discussed. | 02-21-2013 |
| 20130130582 | MODIFIED UREA-FORMALDEHYDE BINDERS FOR NON-WOVEN FIBER GLASS MATS - Urea-formaldehyde (UF) resin binder compositions modified with a starch are described. The binder compositions may include about 1 wt. % to about 10 wt. % of a starch. In addition, fiber reinforced composites are described. The composites may include organic or inorganic fibers and a polymer matrix formed from a binder composition. The binder composition may include a UF resin and about 1 wt. % to about 10 wt. % of a starch. | 05-23-2013 |
| 20140130435 | FIRE RESISTANT COMPOSITE BOARDS AND METHODS - Embodiments of the invention provide roofing boards and roofing systems having improved fire resistance properties and methods related to the same. According to one aspect, a roofing system is provided. The roofing system includes roofing panels positioned atop structural support members to form a roof deck. Roofing boards are positioned atop the roof deck and coupled thereto and a roofing membrane is positioned atop the roofing boards and coupled therewith. The roofing boards include a coating of a mineral based material applied to one or more surfaces in an amount between the range of about 0.10 lbs/ft | 05-15-2014 |
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| 20120217453 | Metallic Nanofiber Ink, Substantially Transparent Conductor, and Fabrication Method - An exemplary printable composition comprises a liquid or gel suspension of a plurality of metallic nanofibers; a first solvent; and a viscosity modifier, resin, or binder. In various embodiments, the metallic nanofibers are between about 10 microns to about 100 microns in length, are between about 10 nm to about 120 nm in diameter, and are typically functionalized with a coating or partial coating of polyvinyl pyrrolidone or a similar compound. An exemplary metallic nanofiber ink which can be printed to produce a substantially transparent conductor comprises a plurality of metallic nanofibers; one or more solvents such as 1-butanol, ethanol, 1-pentanol, n-methylpyrrolidone, cyclohexanone, cyclopentanone, 1-hexanol, acetic acid, cyclohexanol, or mixtures thereof; and a viscosity modifier, resin, or binder such as polyvinyl pyrrolidone or a polyimide, for example. | 08-30-2012 |
| 20140054515 | Metallic Nanowire Ink Composition for a Substantially Transparent Conductor - An exemplary printable composition comprises a liquid or gel suspension of a plurality of metallic nanofibers or nanowires; a first solvent; and a viscosity modifier, resin, or binder. In various embodiments, an exemplary metallic nanowire ink which can be printed to produce a substantially transparent conductor comprises a plurality of metallic nanowires at least partially coated with a first polymer comprising polyvinyl pyrrolidone having a molecular weight less than about 50,000; one or more solvents such as 1-butanol, ethanol, 1-pentanol, n-methylpyrrolidone, cyclohexanone, cyclopentanone, 1-hexanol, acetic acid, cyclohexanol, and mixtures thereof; and a second polymer or polymeric precursor such as polyvinyl pyrrolidone or a polyimide, having a molecular weight greater than about 500,000. | 02-27-2014 |
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| 20120321864 | Metallic Nanofiber Ink, Substantially Transparent Conductor, and Fabrication Method - An exemplary printable composition comprises a liquid or gel suspension of a plurality of metallic nanofibers or nanowires; a first solvent; and a viscosity modifier, resin, or binder. In various embodiments, the metallic nanofibers are between about 10 microns to about 100 microns in length, are between about 10 nm to about 120 nm in diameter, and are typically functionalized with a coating or partial coating of polyvinyl pyrrolidone or a similar compound. An exemplary metallic nanofiber ink which can be printed to produce a substantially transparent conductor comprises a plurality of metallic nanofibers; one or more solvents such as 1-butanol, ethanol, 1-pentanol, n-methylpyrrolidone, cyclohexanone, cyclopentanone, 1-hexanol, acetic acid, cyclohexanol, or mixtures thereof; and a viscosity modifier, resin, or binder such as polyvinyl pyrrolidone or a polyimide, for example. | 12-20-2012 |
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| 20110312050 | CONTINUOUS CATALYTIC GENERATION OF POLYOLS FROM CELLULOSE - A catalytic process for generating at least one polyol from a feedstock comprising cellulose is performed in a continuous manner using a catalyst comprising nickel tungsten carbide. The process involves, contacting, continuously, hydrogen, water, and a feedstock comprising cellulose, with the catalyst to generate an effluent stream comprising at least one polyol and recovering the polyol from the effluent stream. | 12-22-2011 |
| 20110313212 | CONTINUOUS CATALYTIC GENERATION OF POLYOLS FROM CELLULOSE WITH RECYCLE - A catalytic process for generating at least one polyol from a feedstock comprising cellulose is performed in a continuous manner. The process involves, contacting, continuously, hydrogen, water, and a feedstock comprising cellulose, with a catalyst to generate an effluent stream comprising at least one polyol, water, hydrogen, and at least one co-product. The water, hydrogen, and at least one co-product are separated from the effluent stream and recycled to the reaction zone. The polyol is recovered from the effluent stream. | 12-22-2011 |
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| 20090328252 | AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE - Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided. | 12-31-2009 |
| 20110010795 | AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE - Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided. | 01-13-2011 |
| 20110041207 | COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE - Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods of the invention for manipulating oil and/or oleic acid content and/or oleic acid/linoleic acid ratio of a plant or plant part thereof, for marker-assisted selection of a plant, for example, a maize plant, or plant part thereof, having an increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio, and for marker-assisted breeding of the high oil and/or high oleic acid trait. | 02-17-2011 |
| 20110252499 | COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE - Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods of the invention for manipulating oil and/or oleic acid content and/or oleic acid/lineolic acid ratio of a plant or plant part thereof, for marker-assisted selection of a plant, for example, a maize plant, or plant part thereof, having an increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio, and for marker-assisted breeding of the high oil and/or high oleic acid trait. | 10-13-2011 |
| 20120102596 | COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE - Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods for manipulating oil and/or oleic acid content and/or oleic acid/linoleic acid ratio of a plant, for marker-assisted selection of a plant, and for marker-assisted breeding of the high oil and/or high oleic acid trait. | 04-26-2012 |
| 20130198890 | COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE - Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods of the invention for manipulating oil and/or oleic acid content and/or oleic acid/lineolic acid ratio of a plant or plant part thereof, for marker-assisted selection of a plant, for example, a maize plant, or plant part thereof, having an increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio, and for marker-assisted breeding of the high oil and/or high oleic acid trait. | 08-01-2013 |
| 20130254935 | AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE - Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided. | 09-26-2013 |
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| 20120090047 | MAIZE CYTOPLASMIC MALE STERILITY (CMS) C-TYPE RESTORER RF4 GENE, MOLECULAR MARKERS AND THEIR USE - This disclosure concerns high-resolution mapping and candidate gene cloning of Rf4, a maize restorer of fertility gene that restores fertility to C-type cytoplasmic male sterility. The disclosure also relates to molecular markers that are tightly-linked to, or reside within, the Rf4 gene. In some embodiments, methods are provided whereby hybrid seeds may be produced from crosses of a male plant comprising nucleic acid molecular markers that are linked to or that reside within the Rf4 gene and a female plant carrying C-type CMS. | 04-12-2012 |
| 20120174255 | Gene and Variations Associate with BM1 Phenotype, Molecular Markers, and their Use - This disclosure concerns specific naturally-occurring mutant maize cad2 genes, which altered genes contribute to the bm1 maize phenotype in particular maize lines. In some embodiments, compositions and methods are provided that utilize a nucleic acid molecule comprising a mutant cad2 gene, and/or markers linked to a mutant cad2gene. | 07-05-2012 |
| 20140024037 | Endpoint Zygosity Assay To Detect RF4 Gene In Maize - A method is provided for determining the zygosity of an Rf4 gene in a corn plant. A method may include performing a first PCR assay, a second PCR assay, quantifying probes used in the first and second PCR assays, and comparing the quantified probes to determine zygosity. | 01-23-2014 |
| 20140130206 | POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM - The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate dehydrogenase kinase levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. | 05-08-2014 |
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| 20130136941 | FUNCTIONALLY GRADED COATING - In one aspect, composite articles are described comprising multifunctional coatings. A composite article described herein, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising an inner layer and an outer layer, the inner layer comprising a presintered metal or alloy and the outer layer comprising particles disposed in a metal or alloy matrix. | 05-30-2013 |
| 20140057124 | Corrosion And Wear-Resistant Claddings - In one aspect, composite articles are described herein comprising wear-resistant claddings demonstrating improved corrosion resistance. A composite article described herein, in some embodiments, comprises a metal or alloy substrate and a cladding adhered to the substrate, the cladding comprising cemented carbide particles and an alloying additive dispersed in a nickel-based alloy matrix, wherein the alloying additive comprises at least one of copper and molybdenum. | 02-27-2014 |
| 20140271318 | METHODS OF MAKING METAL MATRIX COMPOSITE AND ALLOY ARTICLES - In one aspect, methods of making freestanding metal matrix composite articles and alloy articles are described. A method of making a freestanding composite article described herein comprises disposing over a surface of the temporary substrate a layered assembly comprising a layer of infiltration metal or alloy and a hard particle layer formed of a flexible sheet comprising organic binder and the hard particles. The layered assembly is heated to infiltrate the hard particle layer with metal or alloy providing a metal matrix composite, and the metal matrix composite is separated from the temporary substrate. Further, a method of making a freestanding alloy article described herein comprises disposing over the surface of a temporary substrate a flexible sheet comprising organic binder and powder alloy and heating the sheet to provide a sintered alloy article. The sintered alloy article is then separated from the temporary substrate. | 09-18-2014 |
| 20140271319 | CLADDED ARTICLES AND METHODS OF MAKING THE SAME - In one aspect, methods of making cladded articles are described herein. A method of making a cladded article, in some embodiments, comprises disposing over a surface of a metallic substrate a sheet comprising organic binder and powder metal or powder alloy having a solidus temperature at least 100° C. less than the metallic substrate and heating the powder metal or powder alloy to provide a sintered metal or sintered alloy cladding metallurgically bonded to the metallic substrate. | 09-18-2014 |
| 20140272446 | WEAR-RESISTANT CLADDINGS - In one aspect, articles are described herein comprising wear-resistant claddings. An article described herein, in some embodiments, comprises a metallic substrate and a cladding adhered to the substrate, the cladding including a metal matrix composite layer comprising at least one hard particle tile having a pore structure infiltrated with matrix metal or matrix alloy. Infiltration of the pore structure of the hard particle tile by the matrix metal or alloy can render the tile fully dense or substantially fully dense. | 09-18-2014 |
| 20140342173 | FUNCTIONALLY GRADED COATING - In one aspect, composite articles are described comprising multifunctional coatings. A composite article described herein, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising an inner layer and an outer layer, the inner layer comprising a presintered metal or alloy and the outer layer comprising particles disposed in a metal or alloy matrix. | 11-20-2014 |
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| 20080242123 | Socket for land grid array package - A land grid array socket and a microelectronic assembly including the socket. The socket comprises: a housing; an array of through-contacts on the housing; a solder ball standoff element on a PCB side of the housing; and a seating plane standoff element on a package side of the housing, the seating plane standoff element being aligned with the solder ball standoff element to form a loading force support element therewith. | 10-02-2008 |
| 20080268670 | SELF-BALANCED DUAL L-SHAPED SOCKET - An embodiment of the present invention is a Land Grid Array (LGA) socket. A first L-shaped area has a first center, a first outer long side, and a first outer short side. The first L-shaped area contains a first set of contacts oriented in a first direction. A second L-shaped area has a second center, a second outer long side, and a second outer short side and is located symmetrically to the first L-shaped area. The second L-shaped area contains a second set of contacts oriented in a second direction opposite to the first direction such that pressing a device on the first and second sets of contacts results in approximately zero force and moment. | 10-30-2008 |
| 20090088015 | PICK-AND-PLACE CAP FOR SOCKET ASSEMBLY - Disclosed is a socket assembly for electrically engaging an Integrated Circuit (IC) package with a printed circuit board. The socket assembly includes a socket body and a Pick-and-Place (PnP) cap. The socket body is mounted on the printed circuit board. Further, the PnP cap is capable of detachably mounting on the socket body. An upper surface of the PnP cap includes a raised portion with multiple chamfered portions projecting out from the raised portion. The multiple chamfered portions enable easier detachment of the PnP cap from the socket body. | 04-02-2009 |
| 20090325398 | Land grid array (LGA) socket with cells and method of fabrication and assembly - An LGA socket assembly comprising individual sockets cells, the methods of fabricating and assembling the socket cells into a socket assembly. In an embodiment of the invention, each socket cell comprises an insulative body and a wire. The insulative body is formed around the wire. A first portion of the wire extends from the top surface of the insulative body to form contact tip. A second portion of the wire extends from the bottom surface of the insulative body to form contact paddle. Socket cells are aligned to form a socket assembly. | 12-31-2009 |
| 20140168909 | GAPPED ATTACHMENT STRUCTURES - Attachment structures for electrically coupling a microelectronic package to a microelectronic board/interposer including joint pads formed on the microelectronic board/interposer which provide a gap between respective openings in a solder resist layer of the microelectronic substrate and each of the joint pads. Such attachment structures may reduce or substantially eliminate contact between a solder interconnect and a solder resist layer of the microelectronic board/interposer, which may, in turn, reduce or substantially eliminate the potential of crack initiation and propagation at contact areas between the solder interconnect and a solder resist layer of the microelectronic board/interposer due to stresses induced by a mismatch of thermal expansion between the microelectronic package and the microelectronic board/interposer during thermal cycling. Further, the connection area between the pad and outside circuitry may be maximized, so that the impact to electrical performance due to the pad design may be minimized. | 06-19-2014 |
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| 20100291054 | NOVEL REGULATORY T CELLS AND USES THEREOF - The invention provides isolated regulatory T cells and methods of obtaining regulatory T cells. The invention also provides methods for inhibiting an antigen-specific immune response (e.g., graft rejection, an autoimmune disorder, graft versus host disease, a response to a tumor cell, a response to an infection, and a response to an allergen) in a subject requiring administering an isolated regulatory T cell to the subject. The invention further provides methods for treating or modulating an antigen-specific immune response in a subject requiring administering a regulatory T cell to the subject. | 11-18-2010 |
| 20110045002 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 02-24-2011 |
| 20130195895 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 08-01-2013 |
| 20150079085 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 03-19-2015 |
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| 20120113207 | DETECTION SYSTEM USING HEATING ELEMENT TEMPERATURE OSCILLATIONS - A data storage system includes a recording head and a compensating resistor. The recording head has a heating element. The compensating resistor is in electrical series with the heating element and is external to the recording head. A method includes applying an alternating current at a first angular frequency to a recording head. A voltage drop across the recording head heating element is measured. A component of the voltage drop is extracted. The component has a frequency that is three times the frequency of the first angular frequency. | 05-10-2012 |
| 20120120522 | Head Transducer with Multiple Resistance Temperature Sensors for Head-Medium Spacing and Contact Detection - A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign. | 05-17-2012 |
| 20120201108 | TRANSDUCER HEAD TEMPERATURE MONITORING - Changes in the thermal boundary condition near a close point of an ABS to a media indicate proximity of the ABS with the media. Before contact, heat conduction from the ABS is primarily through convective and/or ballistic heat transfer to air between the ABS and the media. After contact, heat flux primarily flows from the ABS to the media through solid-solid conductive contact. Further, a light source within a HAMR transducer head may create additional thermal variations within the transducer head. These thermal variations create temperature variations within the transducer head. Two resistance temperature sensors on the transducer head at varying distances from the close point and/or light source measure these temperature variations. A temperature difference between the two resistance temperature sensors indicates proximity of the close point to the media and/or light output. | 08-09-2012 |
| 20140023108 | USING FIRST AND SECOND RESISTIVE SENSOR BIAS LEVELS TO DETECT HEAD-TO-DISK CONTACT AND/OR CLEARANCE - A bias signal is applied to a resistive thermal sensor located proximate a magnetic media reading surface of a magnetic sensor. The bias signal is modulated between first and second bias levels. First and second resistances of the resistive thermal sensor corresponding to the first and second bias levels are measured. Based a difference between the first and second resistances caused by in increase in thermal conductivity between the magnetic sensor and a medium as the magnetic head gets closer to the medium, at least one of a spacing and a contact between the magnetic sensor and the medium are determined. | 01-23-2014 |
| 20140029402 | Detection System Using Heating Element Temperature Oscillations - A data storage system includes a recording head and a compensating resistor. The recording head has a heating element. The compensating resistor is in electrical series with the heating element and is external to the recording head. A method includes applying an alternating current at a first angular frequency to a recording head. A voltage drop across the recording head heating element is measured. A component of the voltage drop is extracted. The component has a frequency that is three times the frequency of the first angular frequency. | 01-30-2014 |
| 20140133053 | METHOD AND APPARATUS USED FOR DETERMINING FRICTION BETWEEN SLIDER AND ROTATING DATA STORAGE MEDIUM - A flexible member is coupled between an actuator arm and a slider. The flexible member facilitates relative motion in a tangential direction of a rotating medium. The relative motion is detected via a displacement sensor, and a friction between the slider and the rotating medium is determined based on the sensed relative motion. | 05-15-2014 |
| 20140334275 | TRANSDUCER HEAD TEMPERATURE MONITORING - Changes in the thermal boundary condition near a close point of an ABS to a media indicate proximity of the ABS with the media. Before contact, heat conduction from the ABS is primarily through convective and/or ballistic heat transfer to air between the ABS and the media. After contact, heat flux primarily flows from the ABS to the media through solid-solid conductive contact. Further, a light source within a HAMR transducer head may create additional thermal variations within the transducer head. These thermal variations create temperature variations within the transducer head. Two resistance temperature sensors on the transducer head at varying distances from the close point and/or light source measure these temperature variations. A temperature difference between the two resistance temperature sensors indicates proximity of the close point to the media and/or light output. | 11-13-2014 |
| 20140347760 | HEAD TRANSDUCER WITH MULTIPLE RESISTANCE TEMPERATURE SENSORS FOR HEAD-MEDIUM SPACING AND CONTACT DETECTION - A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign. | 11-27-2014 |
| 20140355150 | HEAD TRANSDUCER WITH MULTIPLE RESISTANCE TEMPERATURE SENSORS FOR HEAD-MEDIUM SPACING AND CONTACT DETECTION - A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign. | 12-04-2014 |
