Patent application number | Description | Published |
20080318991 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 - The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases. | 12-25-2008 |
20090291946 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 11-26-2009 |
20100130467 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS - The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 05-27-2010 |
20100137401 | 2-METHYLPROP ANAMIDES AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 06-03-2010 |
20100173901 | Substituted Heterocyclic Compounds - The present invention relates to substituted heterocyclic compounds of Formula I: | 07-08-2010 |
20110136781 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS - The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 06-09-2011 |
20110144113 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS - The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 06-16-2011 |
20120015928 | Amido Compounds And Their Use As Pharmaceuticals - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 01-19-2012 |
20120040964 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 02-16-2012 |
20120122858 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 05-17-2012 |
20120165305 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 - The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases. | 06-28-2012 |
20130018068 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 - The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases. | 01-17-2013 |
20130244999 | Substituted Heterocyclic Compounds - The present invention relates to substituted heterocyclic compounds of Formula I: | 09-19-2013 |
20130324515 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS - The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 12-05-2013 |
20130338134 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS - The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer. | 12-19-2013 |
20140243308 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 - The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases. | 08-28-2014 |
Patent application number | Description | Published |
20110111595 | Chemical mechanical polishing composition and methods relating thereto - A chemical mechanical polishing composition useful for chemical mechanical polishing of a substrate, wherein the substrate comprises a silicon oxide material and a silicon nitride material; and methods of making and using the chemical mechanical polishing composition. The chemical mechanical polishing composition comprises, as initial components: at least one of a first substance and a second substance; wherein the first substance is according to formula I | 05-12-2011 |
20110230048 | Method of polishing a substrate comprising polysilicon, silicon oxide and silicon nitride - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon, silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; an alkyl aryl polyether sulfonate compound, wherein the alkyl aryl polyether sulfonate compound has a hydrophobic portion having an alkyl group bound to an aryl ring and a nonionic acyclic hydrophilic portion having 4 to 100 carbon atoms; and a substance according to formula I | 09-22-2011 |
20110230049 | Method of polishing a substrate comprising polysilicon and at least one of silicon oxide and silicon nitride - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon and at least one of silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and an acyclic organosulfonic acid compound, wherein the acyclic organosulfonic acid compound has an acyclic hydrophobic portion having 6 to 30 carbon atoms and a nonionic acyclic hydrophilic portion having 10 to 300 carbon atoms; providing a chemical mechanical polishing pad with a polishing surface; moving the polishing surface relative to the substrate; dispensing the chemical mechanical polishing composition onto the polishing surface; and, abrading at least a portion of the substrate to polish the substrate; wherein at least some of the polysilicon is removed from the substrate; and, wherein at least some of the at least one of silicon oxide and silicon nitride is removed from the substrate. | 09-22-2011 |
20110230050 | METHOD OF POLISHING A SUBSTRATE COMPRISING POLYSILICON AND AT LEAST ONE OF SILICON OXIDE AND SILICON NITRIDE - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon and at least one of silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and an alkyl aryl polyether sulfonate compound, wherein the alkyl aryl polyether sulfonate compound has a hydrophobic portion having an alkyl group bound to an aryl ring and a nonionic acyclic hydrophilic portion having 4 to 100 carbon atoms; providing a chemical mechanical polishing pad with a polishing surface; moving the polishing surface relative to the substrate; dispensing the chemical mechanical polishing composition onto the polishing surface; and, abrading at least a portion of the substrate to polish the substrate; wherein at least some of the polysilicon is removed from the substrate; and, wherein at least some of the at least one of silicon oxide and silicon nitride is removed from the substrate. | 09-22-2011 |
20110244685 | Method of chemical mechanical polishing a substrate with polishing composition adapted to enhance silicon oxide removal - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises silicon oxide; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and a substance according to formula I | 10-06-2011 |
20110306211 | Stabilized Chemical Mechanical Polishing Composition And Method Of Polishing A Substrate - A chemical mechanical polishing composition, comprising, as initial components: water; 0.1 to 40 wt % abrasive having an average particle size of 5 to 150 nm; 0.001 to 1 wt % of an adamarityl substance according to formula (II); 0 to 1 wt % diquaternary substance according to formula (I); and, 0 to 1 wt % of a quaternary ammonium compound. Also, provided is a method for chemical mechanical polishing using the chemical mechanical polishing composition. | 12-15-2011 |
20120070989 | Stabilized, Concentratable Chemical Mechanical Polishing Composition And Method Of Polishing A Substrate - A chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; a diquaternary substance according to formula (I), wherein each X is independently selected from N and P; wherein R | 03-22-2012 |
20120070990 | Slurry Composition Having Tunable Dielectric Polishing Selectivity And Method Of Polishing A Substrate - A chemical mechanical polishing slurry composition, comprising, as initial components: water; an abrasive; a halogenated quaternary ammonium compound according to formula (I), wherein R | 03-22-2012 |
20120258598 | Stabilized Chemical Mechanical Polishing Composition and Method of Polishing a Substrate - A chemical mechanical polishing composition, comprising, as initial components: water; 0.1 to 20 wt % abrasive having an average particle size of 5 to 50 nm; and, 0.001 to 1 wt % of an adamantyl substance according to formula (II): | 10-11-2012 |
20120276742 | Chemical Mechanical Polishing Composition and Method For Polishing Germanium-Antimony-Tellurium Alloys - A method for chemical mechanical polishing of a substrate comprising a germanium-antimony-tellurium chalcogenide phase change alloy (GST) using a chemical mechanical polishing composition consisting essentially of, as initial components: water; an abrasive; a material selected from ethylene diamine tetra acetic acid and salts thereof; and an oxidizing agent; wherein the chemical mechanical polishing composition facilitates a high GST removal rate with low defectivity. | 11-01-2012 |
20120276819 | Chemical Mechanical Polishing Composition and Method For Polishing Phase Change Alloys - A method for chemical mechanical polishing of a substrate comprising a germanium-antimony-tellurium chalcogenide phase change alloy (GST) using a chemical mechanical polishing composition comprising, as initial components: water; an abrasive; at least one of a phthalic acid, a phthalic anhydride, a phthalate compound and a phthalic acid derivative; a chelating agent; a poly(acrylic acid-co-maleic acid); and an oxidizing agent; wherein the chemical mechanical polishing composition facilitates a high GST removal rate with low defectivity. | 11-01-2012 |
20130045598 | Method for chemical mechanical polishing tungsten - A method for chemical mechanical polishing of a substrate comprising tungsten using a nonselective chemical mechanical polishing composition. | 02-21-2013 |
Patent application number | Description | Published |
20080302703 | CATALYTIC PROCESS FOR THE TREATMENT OF ORGANIC COMPOUNDS - A process for the catalytic reaction of organic compounds, in which the organic compounds are contacted with a catalyst comprising an interstitial metal hydride, having a reaction surface, to produce a catalyst-organic compound mixture, energy is applied, monatomic hydrogen is produced at the reaction surface of the interstitial metal hydride, and the organic compounds are reacted with the monatomic hydrogen. Reactions accomplished by this process include petroleum hydrocracking and hydrotreating processes. The method's performance can be further enhanced using radio frequency (RF) or microwave energy. | 12-11-2008 |
20100089741 | PRODUCTION OF BIOFUELS - A method is provided for the production of biofuels. The method includes contacting at least one of a plant oil, an animal oil and a mixture thereof with a catalyst including an acid or solid acid, thereby producing a catalyst-oil mixture. RF or microwave energy is applied to at least one of the catalyst, the plant oil, the animal oil, the mixture, and the catalyst-oil mixture to produce the biofuel. The process can be adjusted to produce gasoline, kerosene, jet fuel, or diesel range middle distillate products. | 04-15-2010 |
20100264015 | METHODS FOR PRODUCING BIODIESEL - Transesterification, esterification, and esterification-transesterification (both one-step and two-step) for producing biofuels. The process may be enhanced by one or more of the following: 1) applying microwave or RF energy; 2) passing reactants over a heterogeneous catalyst at sufficiently high velocity to achieve high shear conditions; 3) emulsifying reactants with a homogeneous catalyst; or 4) maintaining the reaction at a pressure at or above autogeneous pressure. Enhanced processes using one or more of these steps can result in higher process rates, higher conversion levels, or both. | 10-21-2010 |
20110119991 | INTERSTITIAL METAL HYDRIDE CATALYST ACTIVITY REGENERATION AND HYDROPROCESSING PROCESSES - The present invention relates to new processes for regenerating oxidized interstitial metal hydride containing catalysts prior to the use of such catalysts in a hydroprocessing process. Interstitial metal hydride containing catalysts are easily oxidized in the environment and once oxidized, the hydroprocessing activity of the interstitial metal hydrides is most often severely diminished and this lost activity due to oxidization of the iMeH is not susceptible to recovery under hydroprocessing conditions. As a result, these catalysts in the present art require considerable special handling in inert environments all through processes from fabrication, shipping, loading, use, and maintenance of the catalyst systems to protect the activity of the interstitial metal hydride components. The present invention embodies a process regenerating oxidized interstitial metal hydride containing catalysts prior to their use in a hydroprocessing environment, thereby eliminating the requirement for maintaining the interstitial metal hydride containing catalysts in an inert environment, and allowing the handling of such catalysts in an oxidized condition prior to use. | 05-26-2011 |
20110119992 | OXIDATION RESISTANT INTERSTITIAL METAL HYDRIDE CATALYSTS AND ASSOCIATED PROCESSES - The present invention relates to novel interstitial metal hydrides and catalyst containing interstitial metal hydrides that are resistant to oxidation and resultant loss of catalytic activity. The processes of the present invention include use of these improved, oxidation resistant interstitial metal hydride compositions for improved overall hydrogenation, product conversion, as well as sulfur reduction in hydrocarbon feedstreams. | 05-26-2011 |
20110119993 | HIGH SEVERITY HYDROPROCESSING INTERSTITIAL METAL HYDRIDE CATALYSTS AND ASSOCIATED PROCESSES - The present invention relates to the processing of hydrocarbon-containing feedstreams in the presence of an interstitial metal hydride containing catalyst and hydrogen at process conditions of at least 400 psig pressure and temperatures of at least 200° C. These processes use interstitial metal hydrides that possess significant hydrogen capacities and high hydrogen kinetics rate properties. The catalysts and processes of the present invention may be used with or without radio frequency or microwave energy and are preferably run under conditions of high hydrogen partial pressure above about 350 psia. The catalysts and processes of the present invention can improve overall hydrogenation, product conversion, as well as sulfur reduction in hydrocarbon feedstreams as compared to processes of the prior art operated under similar conditions. | 05-26-2011 |
Patent application number | Description | Published |
20090105375 | Ultrathin Multilayered Films for Controlled Release of Anionic Reagents - Multilayered films, particularly ultrathin multilayered films comprising cationic polymers which are useful for controlled release of anionic species, particularly for controlled release of nucleic acids. The multilayer films herein are useful for temporal controlled released of anionic species, particularly one or more anionic peptides, proteins, nucleic acids or other anionic biological agents. In one aspect, the invention relates to multilayer films which release anionic species (anions) with separate and/or distinct release profiles, particularly wherein the anions are one or more anionic peptides, proteins or nucleic acids or other anionic biological agents | 04-23-2009 |
20090170179 | COVALENT ASSEMBLY OF ULTRATHIN POLYMERIC FILMS - In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films. | 07-02-2009 |
20100048736 | ANIONIC CHARGE-DYNAMIC POLYMERS FOR RELEASE OF CATIONIC AGENTS - Materials and methods for the generation of polyelectrolyte multilayers that can erode to release cationic components. The multilayers comprise layers that contain one or more cations and one or more charge-dynamic anionic polymers. Charge-dynamic anionic polymers contain side chains having removable functional groups. Removal of the functional groups results in a change in the net change in the charge of the polymer which can disrupt interactions between cations and the anionic polymers and facilitate release of cations. | 02-25-2010 |
20120065616 | Ultrathin Multilayered Films for Controlled Release of Anionic Reagents - Multilayered films, particularly ultrathin multilayered films comprising cationic polymers which are useful for controlled release of anionic species, particularly for controlled release of nucleic acids. The multilayer films herein are useful for temporal controlled released of anionic species, particularly one or more anionic peptides, proteins, nucleic acids or other anionic biological agents. In one aspect, the invention relates to multilayer films which release anionic species (anions) with separate and/or distinct release profiles, particularly wherein the anions are one or more anionic peptides, proteins or nucleic acids or other anionic biological agents. | 03-15-2012 |
20130122055 | Anionic Charge-Dynamic Polymers for Release of Cationic Agents - Materials and Methods for the generation of polyelectrolyte multilayers that can erode to release cationic components. The multilayers comprise layers that contain one or more cations and one or more charge-dynamic anionic polymers. Charge-dynamic anionic polymers contain side chains having removable functional groups. Removal of the functional groups results in a change in the net change in the charge of the polymer which can disrupt interactions between cations and the anionic polymers and facilitate release of cations. | 05-16-2013 |
Patent application number | Description | Published |
20080212180 | POLARIZATION INDEPENDENT RAMAN IMAGING WITH LIQUID CRYSTAL TUNABLE FILTER - A high passband transmission ratio in microscopic Raman spectral imaging and other applications is obtained by splitting a light beam from an objective lens into two orthogonal polarized components processed along laterally spaced paths through the same liquid crystal tunable filter (LCTF) and imaging lens. At least one of the beams from a polarizing beam splitter is rotated using a wave plate, to cause both beams to be polarized at the nominal plane polarization angle required at the input to the LCTF. Laterally spaced beams emerge from the LCTF to be focused through a same imaging lens, as a single image on a CCD photosensor array. This arrangement ideally achieves 100% transmission in the passband, compared to 50% if the light beam had been coupled directly to the LCTF. | 09-04-2008 |
20090040519 | Method and apparatus for reconfigurable field of view in a fast-based imaging system - A system and method to obtain a variable field of view (FOV) of a sample without requiring an increase in an imaging CCD array size. In a fiber array spectral translator (FAST) based chemical imaging system, the fibers in the fiber bundle may be organized in different 2D “zones”. Each zone may include a predetermined number of fibers. Each 2D zone of fibers at the signal input end is organized as a separate linear array (1D) at the spectrometer slit input end. Depending on the user-selected FOV, one or more zones of fibers may be selected for signal input (into the spectrometer) by a motorized mobile slit port or linear translating stage, which will sequentially scan output from each selected linear fiber array into the spectrometer slit. The user can switch from one FOV size to another, thereby activating the linear translating stage to gather signals from appropriate linear fiber arrays corresponding to fiber zones associated with the selected FOV. A CCD imager may be used to collect optical data and generate 2D spatially accurate wavelength resolved images of the user-selected FOV. | 02-12-2009 |
20090091754 | Compact Spectrometer - Spectrometers, particularly compact spectrometers, are constructed without sacrificing performance characteristics, but with their instrument/device volume being reduced significantly. The light propagation path, either in transparent media or in free space, of the optical beams emitting from a small input aperture/slit of a spectrometer, is caused to be two-dimensional or unilateralized (propagating within a thin layer of air or media), enabling physical sizes of any optical elements needed thereafter to construct a spectrometer to be reduced significantly in one dimension. As a result, a significant reduction of instrument/device volume is achieved, which is applicable to and beneficial to either a classical dispersion spectrometer or a compact dispersion spectrometer. | 04-09-2009 |
20100265498 | METHOD AND APPARATUS FOR MICROLENS ARRAY/FIBER OPTIC IMAGING - A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fiber bundle of M fibers; a second optical fiber bundle of N fibers; an optical fiber switch; and a charge coupled device, wherein the image comprises plural sub-images, and wherein each sub-image is formed from photons scattered from a predetermined two spatial dimension portion of the sample, and wherein the scattered photons forming each sub-image have a predetermined wavelength different from a predetermined wavelength of scattered photons forming the other sub-images, and wherein the scattered photons for each sub-image are collected substantially simultaneously. | 10-21-2010 |
20100309454 | SPECTROMETERS MINIATURIZED FOR WORKING WITH CELLULAR PHONES AND OTHER PORTABLE ELECTRONIC DEVICES - Based on the present invention, superior compact spectrometers may be constructed and integrated into a cellular phone, or attached to a cellular phone. Such a cellular phone may be a PDA phone, which supplies electrical power to the said spectrometer, provided with data storage, signal processing capability, and real-time display. As a combined standalone system, it allows spectroscopic measurements to be fulfilled in real-time applications in field, and results can be sent out in wireless communication to a remote station or to another cellular phone user in order to share the measurement results right away. When the system is used with a laser to function as a Raman spectrometer system, it can fulfill many daily routine tasks encountered by ordinary civilians, for example, the blood glucose monitoring for diabetes patients at home in a non-invasive manner. | 12-09-2010 |
20130114077 | SPECTROMETER MINIATURIZED FOR WORKING WITH CELLULAR PHONES AND OTHER PORTABLE ELECTRONIC DEVICES - Based on the present invention, superior compact spectrometers may be constructed and integrated into a cellular phone, or attached to a cellular phone. Such a cellular phone may be a PDA phone, which supplies electrical power to the said spectrometer, provided with data storage, signal processing capability, and real-time display. As a combined standalone system, it allows spectroscopic measurements to be fulfilled in real-time applications in field, and results can be sent out in wireless communication to a remote station or to another cellular phone user in order to share the measurement results right away. When the system is used with a laser to function as a Raman spectrometer system, it can fulfill many daily routine tasks encountered by ordinary civilians, for example, the blood glucose monitoring for diabetes patients at home in a non-invasive manner. | 05-09-2013 |
Patent application number | Description | Published |
20090024086 | Micro-steerable catheter - Micro-streerable catheters for use in delivering therapeutic treatment in the body, such as ablation and cauterization, and which exhibit precise movement are disclosed. Embodiments include electrical micro-catheters that comprise of electroactive polymers. A preferred embodiment includes a programmable catheter. | 01-22-2009 |
20090030152 | High Electric Energy Density Polymer Capacitors With Fast Discharge Speed and High Efficiency Based On Unique Poly (Vinylidene Fluoride) Copolymers and Terpolymers as Dielectric Materials - An improved charge or energy storage device having a dielectric charge or energy storage layer including:
| 01-29-2009 |
20100067172 | HIGH ELECTRIC ENERGY DENSITY POLYMERIC COMPOSITIONS, METHODS OF THE MANUFACTURE THEREFOR, AND ARTICLES COMPRISING THE SAME - Examples of the present invention relate generally to high electric energy density polymer film capacitors with high charge-discharge efficiency and fast discharge speed. For example, a high energy density polymer capacitor may be fabricated using a polymer blend comprising one or more high dielectric constant PVDF-based polymers (including homopolymers, copolymers and/or terpolymers) and one or more other polymer with low dielectric loss and high volume resistivity compared to the one or more PVDF-based polymers. An example film capacitor may comprise a high temperature fluoropolymer with dielectric loss lower than 0.2% and good film manufacturability. Polymer films can be stretched and orientated at least in one direction to make thinner films with improved performance. Film capacitors can be made by winding metallized films, plain films with metal foils, or using a hybrid construction where the dielectric films comprise the new compositions. Capacitors can also have a multilayer construction where the films are metallized. | 03-18-2010 |
20110016885 | REFRIGERATION DEVICES BASED ON POLAR-POLYMERS - Cooling devices (i.e., a heat exchanger) based on polymers which exhibits a temperature change upon application or removal of an electrical field or voltage are disclosed. Also disclosed are methods for cooling using such polymers. | 01-27-2011 |
20110038625 | ELECTROMECHANICAL POLYMER ACTUATORS - An adaptive lens comprises an actuator and a lens, the lens being mechanically coupled to the actuator so that energization of the actuator adjusts a focal point of the lens. The actuator may comprise a multilayer stack of electromechanical polymer (EMP) layers, having electrodes configured to apply an electric field across each EMP layer. The actuator may be operable to move and/or deform a lens, so as to adjust the focus properties of the lens. In some examples, the actuator has an annular shape, supporting a lens within the inner radius of the annulus. The lens position may be adjusted in an axial direction. In other examples, the actuator may be mechanically coupled a surface of a deformable lens, either directly or through another element of a lens structure. A strain applied to the lens modifies a curved surface of the lens, hence modifying the focal length of the lens. | 02-17-2011 |
20110110015 | Methods to improve the efficiency and reduce the energy losses in high energy density capacitor films and articles comprising the same - A multilayer film useful for capacitive applications comprises a high energy density layer and a dielectric blocking layer. In some embodiments, a conducting film is located between the high energy density layer and the blocking layer. The high energy density layer may be a fluoropolymer, such as a polymer or copolymer of poly-1,1-difluoroethene or a derivative thereof. The multilayer film may have high energy density (for example,. >8 J/cm | 05-12-2011 |
20110228442 | CAPACITOR HAVING HIGH TEMPERATURE STABILITY, HIGH DIELECTRIC CONSTANT, LOW DIELECTRIC LOSS, AND LOW LEAKAGE CURRENT - Examples of the present invention include high electric energy density polymer film capacitors with high dielectric constant, low dielectric dissipation tangent, and low leakage current in a broad temperature range. More particularly, examples include a polymer film capacitor in which the dielectric layer comprise a copolymer of a first monomer (such as tetrafluoroethylene) and a second polar monomer. The second monomer component may be selected from vinylidene fluoride, trifluoroethylene or their mixtures, and optionally other monomers may be included to adjust the mechanical performance. The capacitors can be made by winding metallized films, plain films with metal foils, or hybrid construction where the films comprise the new compositions. The capacitors can be used in DC bus capacitors and energy storage capacitors in pulsed power systems. | 09-22-2011 |
20120178880 | POLYMER BLENDS ELECTROSTRICTIVE TERPOLYMER WITH OTHER POLYMERS - Polymer blends having improved electromechanical responses and mechanical properties for use in electromechanical application are disclosed. In particular, polymer blend including at least one electrostrictive terpolymer, e.g., poly(vinylidene fluoride-trifluoroethylene-chlorofluoroethylene) (P(VDF-TrFE-CFE)) or a derivative thereof, and at least one fluoropolymer, e.g., PVDF or derivative thereof such as PVD-TrFE are disclosed. The polymer blends advantageously have a transverse strain, i.e., a strain perpendicular to the applied electric field direction, that is about 1.5% or higher (as measured at 100 MV/m) while also having an elastic modulus of no less than about 400 MPa (as measured at 30° C. and 1 Hz by dynamic mechanical analyzer). | 07-12-2012 |
20120239032 | MICRO-STEERABLE CATHETER - Micro-streerable catheters for use in delivering therapeutic treatment in the body, such as ablation and cauterization, and which exhibit precise movement are disclosed. Embodiments include electrical micro-catheters that comprise of electroactive polymers. A preferred embodiment includes a programmable catheter. | 09-20-2012 |
20150027132 | COOLING DEVICE INCLUDING AN ELECTROCALORIC COMPOSITE - Cooling devices, heat pumps, and climate controlling devices employing an electrocaloric composite of high thermal conductivity and significant electrocaloric effect are disclosed. The electrocaloric composites include a combination of one or more EC-fluoropolymers and their blends with one or more electric-insulating fillers of high thermal conductivity. | 01-29-2015 |
20150033762 | REGENERATIVE ELECTROCALORIC COOLING DEVICE - A regenerative electrocaloric (EC) device is provided. The regenerative EC device uses a special configuration to expand the temperature span T | 02-05-2015 |
Patent application number | Description | Published |
20090024086 | Micro-steerable catheter - Micro-streerable catheters for use in delivering therapeutic treatment in the body, such as ablation and cauterization, and which exhibit precise movement are disclosed. Embodiments include electrical micro-catheters that comprise of electroactive polymers. A preferred embodiment includes a programmable catheter. | 01-22-2009 |
20100067172 | HIGH ELECTRIC ENERGY DENSITY POLYMERIC COMPOSITIONS, METHODS OF THE MANUFACTURE THEREFOR, AND ARTICLES COMPRISING THE SAME - Examples of the present invention relate generally to high electric energy density polymer film capacitors with high charge-discharge efficiency and fast discharge speed. For example, a high energy density polymer capacitor may be fabricated using a polymer blend comprising one or more high dielectric constant PVDF-based polymers (including homopolymers, copolymers and/or terpolymers) and one or more other polymer with low dielectric loss and high volume resistivity compared to the one or more PVDF-based polymers. An example film capacitor may comprise a high temperature fluoropolymer with dielectric loss lower than 0.2% and good film manufacturability. Polymer films can be stretched and orientated at least in one direction to make thinner films with improved performance. Film capacitors can be made by winding metallized films, plain films with metal foils, or using a hybrid construction where the dielectric films comprise the new compositions. Capacitors can also have a multilayer construction where the films are metallized. | 03-18-2010 |
20110038625 | ELECTROMECHANICAL POLYMER ACTUATORS - An adaptive lens comprises an actuator and a lens, the lens being mechanically coupled to the actuator so that energization of the actuator adjusts a focal point of the lens. The actuator may comprise a multilayer stack of electromechanical polymer (EMP) layers, having electrodes configured to apply an electric field across each EMP layer. The actuator may be operable to move and/or deform a lens, so as to adjust the focus properties of the lens. In some examples, the actuator has an annular shape, supporting a lens within the inner radius of the annulus. The lens position may be adjusted in an axial direction. In other examples, the actuator may be mechanically coupled a surface of a deformable lens, either directly or through another element of a lens structure. A strain applied to the lens modifies a curved surface of the lens, hence modifying the focal length of the lens. | 02-17-2011 |
20110110015 | Methods to improve the efficiency and reduce the energy losses in high energy density capacitor films and articles comprising the same - A multilayer film useful for capacitive applications comprises a high energy density layer and a dielectric blocking layer. In some embodiments, a conducting film is located between the high energy density layer and the blocking layer. The high energy density layer may be a fluoropolymer, such as a polymer or copolymer of poly-1,1-difluoroethene or a derivative thereof. The multilayer film may have high energy density (for example,. >8 J/cm | 05-12-2011 |
20110228442 | CAPACITOR HAVING HIGH TEMPERATURE STABILITY, HIGH DIELECTRIC CONSTANT, LOW DIELECTRIC LOSS, AND LOW LEAKAGE CURRENT - Examples of the present invention include high electric energy density polymer film capacitors with high dielectric constant, low dielectric dissipation tangent, and low leakage current in a broad temperature range. More particularly, examples include a polymer film capacitor in which the dielectric layer comprise a copolymer of a first monomer (such as tetrafluoroethylene) and a second polar monomer. The second monomer component may be selected from vinylidene fluoride, trifluoroethylene or their mixtures, and optionally other monomers may be included to adjust the mechanical performance. The capacitors can be made by winding metallized films, plain films with metal foils, or hybrid construction where the films comprise the new compositions. The capacitors can be used in DC bus capacitors and energy storage capacitors in pulsed power systems. | 09-22-2011 |
20120239032 | MICRO-STEERABLE CATHETER - Micro-streerable catheters for use in delivering therapeutic treatment in the body, such as ablation and cauterization, and which exhibit precise movement are disclosed. Embodiments include electrical micro-catheters that comprise of electroactive polymers. A preferred embodiment includes a programmable catheter. | 09-20-2012 |
20130123692 | Steerable Medical Guide Wire Device - A steerable guide wire including one or more electroactive polymer layers, wherein each EAP layer is disposed between a layer of a first electrode and a layer of a plurality of second electrodes. | 05-16-2013 |
20140035735 | LOCALIZED MULTIMODAL ELECTROMECHANICAL POLYMER TRANSDUCERS - A localized multimodal haptic system includes one or more electromechanical polymer (EMP) transducers, each including an EMP layer, such as an electrostrictive polymer active layer. In some applications the EMP transducer may perform an actuator function or a sensor function, or both. The EMP polymer layer has a first surface and a second surface on which one or more electrodes are provided. The EMP layer of the EMP actuator may be 5 microns thick or less. The EMP transducers may provide local haptic response to a local a stimulus. In one application, a touch sensor may be associated with each EMP transducer, such that the haptic event at the touch sensor may be responded to by activating only the associated EMP transducer. Furthermore, the EMP transducer may act as its own touch sensor. A variety of haptic responses may be made available. The EMP transducers may be used in various other applications, such as providing complex surface morphology and audio speakers. | 02-06-2014 |
20140139328 | HAPTIC SYSTEM WITH LOCALIZED RESPONSE - A localized multimodal haptic system includes one or more electromechanical polymer (EMP) transducers, each including an EMP layer, such as an electrostrictive polymer active layer. In some applications the EMP transducer may perform an actuator function or a sensor function, or both. The EMP polymer layer has a first surface and a second surface on which one or more electrodes are provided. The EMP layer of the EMP actuator may be 5 microns thick or less. The EMP transducers may provide local haptic response to a local a stimulus. In one application, a touch sensor may be associated with each EMP transducer, such that the haptic event at the touch sensor may be responded to by activating only the associated EMP transducer. Furthermore, the EMP transducer may act as its own touch sensor. A variety of haptic responses may be made available. The EMP transducers may be used in various other applications, such as providing complex surface morphology and audio speakers. | 05-22-2014 |
20140139329 | SYSTEMS INCLUDING ELECTROMECHANICAL POLYMER SENSORS AND ACTUATORS - A localized multimodal haptic system includes one or more electromechanical polymer (EMP) transducers, each including an EMP layer, such as an electrostrictive polymer active layer. In some applications the EMP transducer may perform an actuator function or a sensor function, or both. The EMP polymer layer has a first surface and a second surface on which one or more electrodes are provided. The EMP layer of the EMP actuator may be 5 microns thick or less. The EMP transducers may provide local haptic response to a local a stimulus. In one application, a touch sensor may be associated with each EMP transducer, such that the haptic event at the touch sensor may be responded to by activating only the associated EMP transducer. Furthermore, the EMP transducer may act as its own touch sensor. A variety of haptic responses may be made available. The EMP transducers may be used in various other applications, such as providing complex surface morphology and audio speakers. | 05-22-2014 |
20140139436 | EMP Actuators for Deformable Surface and Keyboard Application - A localized multimodal haptic system includes one or more electromechanical polymer (EMP) transducers, each including an EMP layer, such as an electrostrictive polymer active layer. In some applications the EMP transducer may perform an actuator function or a sensor function, or both. The EMP polymer layer has a first surface and a second surface on which one or more electrodes are provided. The EMP layer of the EMP actuator may be 5 microns thick or less. The EMP transducers may provide local haptic response to a local a stimulus. In one application, a touch sensor may be associated with each EMP transducer, such that the haptic event at the touch sensor may be responded to by activating only the associated EMP transducer. Furthermore, the EMP transducer may act as its own touch sensor. A variety of haptic responses may be made available. The EMP transducers may be used in various other applications, such as providing complex surface morphology, keyboard, braille display, and audio speakers. | 05-22-2014 |
Patent application number | Description | Published |
20100048888 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP). | 02-25-2010 |
20100105933 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP). | 04-29-2010 |
20110092739 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP). | 04-21-2011 |
20110224447 | Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids - The instant invention provides for novel lipid nanoparticles and novel lipid nanoparticle components (specifically cationic lipids) that are useful for the delivery of nucleic acids, specifically siRNA, for therapeutic purposes. | 09-15-2011 |
Patent application number | Description | Published |
20090042893 | KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE - Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. | 02-12-2009 |
20100160316 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS - The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 06-24-2010 |
20110021495 | QUINAZOLES USEFUL AS MODULATORS OF ION CHANNELS - The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 01-27-2011 |
20110245264 | Modulators of G Protein-Coupled Receptor 88 - The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88. | 10-06-2011 |
20110251196 | Modulators of G Protein-Coupled Receptor 88 - The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88. | 10-13-2011 |
20110251204 | Modulators of G Protein-Coupled Receptor 88 - The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88. | 10-13-2011 |
20120040935 | COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED ION CHANNELS - The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 02-16-2012 |
Patent application number | Description | Published |
20090049869 | Thermal Protection Sleeve With Knit Thermal Protection Features And Method Of Construction Thereof - A knit protective sleeve and method of construction thereof provides a continuous and seamless sleeve wall knit from one or more yarns extending between opposite open ends of the sleeve. At least one heat vent opening is integrally knit within the wall between the ends. | 02-26-2009 |
20100084825 | TEXTILE GASKET AND METHOD OF CONSTRUCTION THEREOF - A textile gasket and method of construction thereof for establishing a seal between mating members in a high temperature application is provided. The gasket has a knit, tubular body constructed at least in part of non-metallic, heat-resistant yarns. The body extends between opposite ends with at least one of the ends being rolled toward the other end to form a circumferentially extending rolled portion of a predetermined diameter for receipt between the mating members. | 04-08-2010 |
20110162126 | TRI-LAYER KNIT FABRIC, THERMAL PROTECTIVE MEMBERS FORMED THEREFROM AND METHODS OF CONSTRUCTION THEREOF - A knit fabric, protective sleeve and glove constructed therefrom has three knit layers knit constructed and knit to one another in a single knitting operation to provide the fabric as a single piece of knit material. The fabric includes an outer layer, an inner layer and an intermediate layer sandwiched between the outer and inner layers. The outer layer is knit with a first yarn, the inner layer is knit with a second yarn and the intermediate layer is knit with a third yarn in looped fashion about at least some of the first and second yarns to provide an integrally knit structure having three layers knit stitched together in a single knitting process. | 07-07-2011 |
20120082807 | KNIT SLEEVE WITH KNIT BARRIER EXTENSION HAVING A BARRIER THEREIN AND METHOD OF CONSTRUCTION - A knit sleeve and method of construction thereof is provided. The knit sleeve is constructed including a knit tubular wall and at least one knit tubular extension attached to the wall. Further, a barrier member is disposed in the at least one knit tubular extension. The at least one knit tubular extension and the barrier member are foldable at least partially about the knit tubular wall. | 04-05-2012 |
20130040081 | MULTILAYER TEXTILE SLEEVE AND METHOD OF CONSTRUCTION THEREOF - A multilayer textile sleeve and method of construction thereof is provided. The sleeve includes a textile wall having opposite edges extending lengthwise along a longitudinal axis of the sleeve between opposite ends. The opposite edges are configured to overlap one another to bound a central cavity of the sleeve. The wall has an inner layer with opposite inner and outer faces and an outer layer with opposite inner and outer faces. The inner and outer layers overlap one another and are constructed of interlinked yarn. The inner and outer layers are integrally connected to one another across interlinked portions adjacent the opposite edges by yarn common to each of the inner and outer layers. | 02-14-2013 |
20130299035 | Thermal Textile Sleeve Having An Outer Robust Metallic Layer And Method Of Enhancing The Robustness Of A Thermal Sleeve Therewith - A tubular thermal sleeve assembly for providing protection to an elongate member and method of enhancing the robustness of a thermal sleeve with the assembly is provided. The thermal sleeve assembly includes a tubular wall of insulative material having an outer surface and an inner surface bounding a cavity extending along a longitudinal central axis for receipt of the elongate member. The assembly further includes a flexible outer layer of metallic material extending along the longitudinal central axis between opposite ends with the metallic material having a plurality of openings formed between the opposite ends. | 11-14-2013 |
20140260436 | Corrugated Knit Sleeve and Method of Construction Thereof - A knit tubular sleeve for providing abrasion resistance and expansion restriction to an elastic elongate member extending therethrough and method of construction thereof is provided. The knit tubular sleeve includes a knit tubular wall extending along a longitudinal axis between opposite ends. The knit wall has a plurality of coaxially aligned first regions forming crests spaced axially from one another by intermediate second regions forming troughs between the crests. The first and second regions are knitted over a plurality of courses, with each of the courses comprising a plurality of knit stitches extending circumferentially around the longitudinal axis. The courses of the first regions are formed with a different pattern of knit stitches from the courses of the second regions, wherein the second regions provide the wall with a decreased capacity to expand radially relative to the first regions, thereby inhibiting the elongate member against radial expansion. | 09-18-2014 |
20150056881 | WRAPPABLE MULTI-LAYER HEAT SHIELD - A flexible, wrappable multilayered heat shield is provided. The heat shield includes a reflective metal outermost layer, an innermost layer of high temperature yarn capable of withstanding temperatures up to about | 02-26-2015 |