Zhang, IN
Changchun Zhang, Columbus, IN US
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20080289795 | GEOTHERMAL HEAT EXCHANGER - A pipe for use in a geothermal heat exchange system is disclosed that is insertable into a bore hole having a proximal end and a distal end. The pipe has a proximal end, a distal end and an outer wall member. The outer wall member includes an external surface, and an interior surface defining an interior passageway through which a heat exchange fluid can flow. The pipe also includes a divider extending between opposed points of the interior surface for dividing the interior passageway into an inflow passageway for conducting water from the proximal end to the distal end of the pipe, and an outflow passageway for conducting water from the distal end to the proximal end of the pipe. The divider segregates the water in the outflow passageway from the water in the inflow passageway. | 11-27-2008 |
Dan Zhang, West Lafayette, IN US
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20120185415 | SYSTEM AND METHOD FOR DOMAIN ADAPTION WITH PARTIAL OBSERVATION - System, method and computer program product provides a novel domain adaption/transfer learning approach applied to the problem of classifying abbreviated documents, e.g., short text messages, instant messages, tweets. The proposed method uses a large number of multi-labeled examples (source domain) to improve the learning on the partial observations (target domain). Specifically, a hidden, higher-level abstraction space is learned that is meaningful for the multi-labeled examples in the source domain. This is done by simultaneously minimizing the document reconstruction error and the error in a classification model learned in the hidden space using known labels from the source domain. The partial observations in the target space are then mapped to the same hidden space, and classified into the label space determined by the source domain. Exemplary results provided for a Twitter dataset demonstrate that the method identifies meaningful hidden topics and provides useful classifications of specific tweets. | 07-19-2012 |
20130013539 | SYSTEM AND METHOD FOR DOMAIN ADAPTION WITH PARTIAL OBSERVATION - System, method and computer program product provides a novel domain adaption/transfer learning approach applied to the problem of classifying abbreviated documents, e.g., short text messages, instant messages, tweets. The proposed method uses a large number of multi-labeled examples (source domain) to improve the learning on the partial observations (target domain). Specifically, a hidden, higher-level abstraction space is learned that is meaningful for the multi-labeled examples in the source domain. This is done by simultaneously minimizing the document reconstruction error and the error in a classification model learned in the hidden space using known labels from the source domain. The partial observations in the target space are then mapped to the same hidden space, and classified into the label space determined by the source domain. Exemplary results provided for a Twitter dataset demonstrate that the method identifies meaningful hidden topics and provides useful classifications of specific tweets. | 01-10-2013 |
Dekui Zhang, Columbus, IN US
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20120225138 | PROCESS UTILIZING A COMBINATION OF AN ACID BLEND, PECTIC ENZYME AND YEAST IN A WINE FERMENTATION CONTAINER TO EXTRACT THE BIOLOGICALLY ACTIVE COMPOUNDS FROM MEDICINAL HERBS - A process of preparing herbal medicines according to the present invention comprises the steps of mixing medicinal herb(s) with boiled water, an acid blend, peptic enzyme, yeast nutrients, corn sugar, yeast in a fermentation container; subjecting the mixture to fermentation for a period of time; centrifuging the mixture to remove remaining yeast and non-dissolved materials; subjecting the fluid to reverse osmosis filtration to remove small molecules. The remaining extract is lyophilized to dry powders, which may be further processed into tablets, capsules, and soft capsules. The present invention also relates to the herbal medicines prepared by said process and uses of these herbal medicines in the treatment of human and/or animal diseases. | 09-06-2012 |
Deyi Zhang, Carmel, IN US
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20080214520 | 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists - The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT | 09-04-2008 |
20080300407 | Pyridinoylpiperidines as 5-HT1F agonists - The invention relates to compounds of formula I: | 12-04-2008 |
20090099155 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS - The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzoazepines of Formula I as selective 5-HT | 04-16-2009 |
20110034511 | SUBSTITUTED 2-CARBONYLAMINO-6-PIPERIDINAMINOPYRIDINES AND SUBSTITUTED 1-CARBONYLAMINO-3-PIPERIDINAMINOBENZENES AS 5-HT1F AGONISTS - The present invention relates to compounds of formula I: | 02-10-2011 |
20120028961 | 6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist - The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT | 02-02-2012 |
20120329820 | Pyridinoylpiperidines As 5-HT1F Agonists - The present invention relates to compounds of formula I: | 12-27-2012 |
20150376178 | Pyridinoylpiperidines As 5-HT1F Agonists - The present invention relates to compounds of formula I: | 12-31-2015 |
Fu-Yao Zhang, Carmel, IN US
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20100137602 | PROCESS AND INTERMEDIATES FOR PREPARING ARZOXIFENE - The present invention provides for novel compounds of formula I wherein X is S or S(O); R | 06-03-2010 |
Genqiang Zhang, West Lafayette, IN US
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20130040138 | ULTRATHIN NANOWIRE-BASED AND NANOSCALE HETEROSTRUCTURE BASED THERMOELECTRIC CONVERSION STRUCTURES AND METHOD OF MAKING THE SAME - An ultrathin tellurium nanowire structure is disclosed, including a rod-like crystalline structure of tellurium, wherein the crystalline structure is defined by diameters of between 5-6 nm. In addition, an ultrathin tellurium-based nanowire structure is disclosed including a rod-like crystalline structure of one of lead telluride and bismuth telluride, wherein an ultrathin tellurium nanowire structure is used as a precursor to generate the rod-like crystalline structure. Furthermore, a nanoscale heterostructure tellurium-based nanowire structure is disclosed including a dumbbell-like crystalline heterostructure having a center rod-like portion and one octahedral structure connected to each end of each of the center rod- like portions, wherein the center rod-like portion is a tellurium-based nanowire structure and the octahedral structures are one of lead telluride, cadmium telluride, and bismuth telluride. | 02-14-2013 |
20140261609 | ULTRATHIN NANOWIRE-BASED AND NANOSCALE HETEROSTRUCTURE BASED THERMOELECTRONIC CONVERSION STRUCTURES AND METHOD OF MAKING THE SAME - A nano scale hetero structure tellurium-based nanowire structure is disclosed including a dumbbell-like crystalline heterostructure having a center rod-like portion and one octahedral structure connected to each end of each of the center rod-like portions, wherein the center rod-like portion is a bismuth-telluride nanowire structure and the octahedral structures are lead telluride. | 09-18-2014 |
Genyi Zhang, West Lafayette, IN US
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20140179629 | SLOWLY DIGESTING STARCH AND FERMENTABLE FIBER - Compositions which provide slowly digestible starch and a source of fermentable dietary fiber. Microparticles in which starch is entrapped in a crosslinked matrix to provide dietary benefit. Such microparticles are used to deliver glucose to targeted regions in the small intestine for beneficial physiological effects, and fermentable dietary fiber to the colon to improve colon health and to treat diseases of the colon. Microparticles can be employed to selectively deliver fermentable dietary fiber to targeted portions of the colon. | 06-26-2014 |
Guandong Zhang, Mishawaka, IN US
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20130305881 | METHOD FOR SYNTHESIZING SELF-ASSEMBLING NANOPARTICLES - Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold/gold sulfide nanoparticles by dialyzing samples during the self-assembly process. | 11-21-2013 |
Guoqiang Zhang, Bloomington, IN US
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20100115764 | STRESSED LIQUID CRYSTALS MATERIALS FOR LIGHT MODULATION - A new light modulating material using interconnected unidirectionally oriented microdomains of a liquid crystal, dispersed in a stressed polymer structure, is provided. The light modulating material is prepared by dissolving the liquid crystal in an uncured monomer and then curing the monomer so that the polymer forms a well-developed interpenetrating structure of polymer chains or sheets that is uniformly dispersed through the film. When the film is subjected to stress deformation the liquid crystal undergoes a change in its unidirectional orientation. The concentration of the polymer is high enough to hold the shear stress, but is as low as possible to provide the highest switch of the phase retardation when an electric field is applied. The new materials are optically transparent and provide phase modulation of the incident light opposed to the low driving voltage, linear electro-optical response, and absence of hysteresis. It has been shown that these new materials may be successfully used in display applications, optical modulator, and beam steering devices. | 05-13-2010 |
Haipeng Zhang, Bloomington, IN US
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20140337340 | METHODS AND SYSTEMS FOR ON-DEVICE SOCIAL GROUPING - Methods, systems, and computer readable media for social grouping are provided to perform social grouping of a user's contacts based on the user's interactions with the contacts. A set of attributes associated with interactions between a user and a set of contacts may be determined by a first device. The set of attributes associated with the interactions may be related to the first device. The set of contacts may be organized into a set of groups based on the set of attributes. | 11-13-2014 |
Hong Zhang, Indianapolis, IN US
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20150024939 | STABLE HIGH STRENGTH OIL-IN-WATER EMULSIONS - Novel high-strength herbicidal oil-in-water emulsions containing a water soluble salt of glyphosate and an oil soluble herbicide active ingredient show enhanced stability to oil phase coalescence and active ingredient crystallization by the use of specific surfactants and water immiscible organic solvents. | 01-22-2015 |
Huamin Zhang, West Lafayette, IN US
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20100137383 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS - Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity. | 06-03-2010 |
20110160257 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS - Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity. | 06-30-2011 |
20120202857 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS - Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity. | 08-09-2012 |
20120270911 | NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS - Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity. | 10-25-2012 |
20140030321 | SOLID PHARMACEUTICAL COMPOSITION - The invention described herein pertains to a solid pharmaceutical composition comprising EC145 for reconstitution to provide a solution for intravenous injection, particularly to a lyophilized solid pharmaceutical composition comprising EC145 which has adequate stability for storage at ambient temperature and which is capable of redissolving in an aqueous diluent prior to administration, as well as a process for its manufacture, drug products comprising the composition and methods for using the composition for treating cancer. | 01-30-2014 |
Jian-Ting Zhang, Carmel, IN US
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20110301108 | MATERIALS AND METHODS FOR SENSITIZING MULTIDRUG RESISTANT CELLS - Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that mediate drug efflux found in some types of multidrug resistant caner cells. A series of compounds, including (N-(4-chlorophenyl)-2-[(6-{[4,6-di(4-morpholinyl)-1,3,5-tri-azin-2-yl]amino}-1,3-benzothiazol-2-yl)sulfanyl]acetamide), specifically inhibits ABCG2 and can be used to boost the bio-avail-ability of one or more effective cancer killing drugs, making it possible to use certain widely used chemotherapeutic reagent to treat multidrug resistance cancers. Using these compounds in combination with chemotherapeutic drugs that are substrates for ABCG2 and related proteins may also find utility in treating cancer cells that are not currently identified as multi-drug resistant Additionally, these compounds appear to accelerate the intercellular degradation of ABCG2 and related proteins. They are not toxic to animals at levels at which they effect the activity of ABCG2 expressed in multi-drug resistant cancer lines. | 12-08-2011 |
20150094353 | Inhibitors Targeting the DNA-Binding Domain of Human STAT3 for Treatment of Metastatic Cancers - The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ. | 04-02-2015 |
Jingmin Zhang, West Lafayette, IN US
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20140303365 | Phytoglycogen-Based Compositions, Materials and Methods - The present invention provides methods for treating phytoglycogen-containing materials to generate phytoglycogen compositions with enhanced emulsification attribute. One method comprises contacting a phytoglycogen-containing material with at least one protease. The other method comprises heat treatment of a phytoglycogen-containing material, such as corn kernels. The two methods can be applied independently, or can be applied in combination. Applications of phytoglycogen compositions are also included. | 10-09-2014 |
20150080220 | HIGHLY BRANCHED ALPHA-D-GLUCANS - Compositions including a highly branched alpha-D-glucan or modified forms thereof and a solute compound are described herein. The compositions can provide increased water solubility and/or increased rate of dissolution for the solute compound. The compositions can also provide increased stability for the solute compound. Methods for preparing and using compositions including a solute compound and a highly branched alpha-D-glucan are also described. | 03-19-2015 |
Johnny Zhang, West Lafayette, IN US
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20140165738 | Feedback System and Method for Assessing Fixation and Stability of Implantable Leads - A lead fixation and stability feedback assembly for testing stability and anchoring of a fixation tip of a distal end of an implantable lead to a tissue is disclosed. The assembly includes a first member including a first coupling arrangement configured to couple to a proximal end of an implantable lead, wherein the proximal end of the implantable lead is coupled to a distal end of the implantable lead configured to be anchored to a tissue, and a second member including a second coupling arrangement configured to couple the first member to the second member, the second coupling arrangement configured to decouple the second member from the first member when a predetermined force is applied to pull the second member away from the first member to thereby test the anchoring of the distal end of the implantable lead to the tissue. | 06-19-2014 |
Martin Yi Zhang, West Lafayette, IN US
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20120021559 | HIGH SPEED LASER CRYSTALLIZATION OF PARTICLES OF PHOTOVOLTAIC SOLAR CELLS - A system and method for enhancing the conversion efficiency of thin film photovoltaics. The thin film structure includes a photovoltaic absorbent layer covered by a confinement layer. A laser beam passes through the confinement layer and hits the photovoltaic absorbent layer. The laser can be pulsed to create localized rapid heating and cooling of the photovoltaic absorbent layer. The confinement layer confines the laser induced plasma plume creating a localized high-pressure condition for the photovoltaic absorbent layer. The laser beam can be scanned across specific regions of the thin film structure. The laser beam can be pulsed as a series of short pulses. The photovoltaic absorbent layer can be made of various materials including copper indium diselenide, gallium arsenide, and cadmium telluride. The photovoltaic absorbent layer can be sandwiched between a substrate and the confinement layer, and a molybdenum layer can be between the substrate and the photovoltaic absorbent layer. | 01-26-2012 |
Ruihong Zhang, West Lafayette, IN US
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20160049542 | HOMOGENEOUS PRECURSOR FORMATION METHOD AND DEVICE THEREOF - A direct solution method based on a versatile amine-thiol solvent mixture which dissolves elemental metals, metal salts, organometallic complexes, metal chalcogenides, and metal oxides is described. The metal containing and metal chalcogenide precursors can be prepared by dissolving single or multiple metal sources, chalcogens, and/or metal chalcogenide compounds separately, simultaneously, or stepwise. Multinary metal chalcogenides containing at least one of copper, zinc, tin, indium, gallium, cadmium, germanium, and lead, with at least one of sulfur, selenium, or both are obtained from the above-mentioned metal chalcogenide precursors in the form of thin films, nanoparticles, inks, etc. Furthermore, infiltration of metal containing compounds into a porous structure can be achieved using the amine-thiol based precursors. In addition, due to the appreciable solubility of metal sources, metal chalcogenides, and metal oxides in the mixture of amine(s) and thiol(s), this solvent mixture can be used to remove these materials from a system. | 02-18-2016 |
Ruoqiao Zhang, Lafayette, IN US
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20130343624 | METHODS AND SYSTEMS FOR PERFORMING MODEL-BASED ITERATIVE RECONSTRUCTION - A method for reconstructing image component densities of an object includes acquiring multi-spectral x-ray tomographic data, performing a material decomposition of the multi-spectral x-ray tomographic data to generate a plurality of material sinograms, and reconstructing a plurality of material component density images by iteratively optimizing a functional that includes a joint likelihood term of at least two of the material decomposed sinograms. An x-ray tomography imaging system and a non-transitory computer readable medium are also described herein. | 12-26-2013 |
Ruoqiao Zhang, W. Lafayette, IN US
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20150146845 | METHODS AND SYSTEMS FOR PERFORMING MODEL-BASED IMAGE PROCESSING - Methods and systems for model-based image processing are provided. One method includes selecting at least one reference image from a plurality of reference images, partitioning the at least one reference image into a plurality of patches, generating a probability distribution for each of the patches, and generating a model of a probability distribution for the at least one reference image using the probability distributions for each of the patches. | 05-28-2015 |
Shu Zhang, Columbus, IN US
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20140245722 | SYSTEMS AND TECHNIQUES FOR HEATING UREA INJECTION SYSTEMS - A reductant delivery system is provided for delivery of reductant to an engine exhaust aftertreatment system that is heated during cold temperature conditions. A heat exchange fluid flows through a heat exchange circuit that provides a flow path from the heat source to the doser, from the doser to the reductant storage tank, and from the reductant storage tank to the heat source. A control valve controls the flow of the heat exchange fluid in the heat exchange circuit so that at least one heat exchange cycle includes a circulation period that increases the temperature of the reductant in the doser and storage tank and a termination period where circulation is stopped until reductant temperature in the doser reaches a lower limit. | 09-04-2014 |
20150047727 | DIAPHRAGM PUMP SYSTEM HAVING RE-PRIMING CAPABILITIES - An example system includes a diaphragm pump having a suction port and a discharge port, a urea suction line fluidly coupling a urea supply to the suction port, and a urea discharge line fluidly coupled to the discharge port. A recirculation line fluidly couples the urea discharge line to the urea suction line, and has a flow regulator operationally coupled thereto. A controller is configured to interpret a prime loss condition of the diaphragm pump, and to provide a flow regulator command in response to the prime loss condition. | 02-19-2015 |
20160032805 | Reintroduction of Air in Delivery System Accumulator - According to one embodiment, an apparatus for reintroducing air includes a bypass valve that reduces pressure in an accumulator that stores reductant to less than an air supply pressure of an air supply. The apparatus also includes a metering valve that fills the accumulator with air from the air supply at the air supply pressure, and a pump that pumps reductant into the accumulator. | 02-04-2016 |
20160040575 | PUMP PURGE FOR UREA DOSING SYSTEM - According to one embodiment, a diesel exhaust fluid purging system includes a metering valve with a supply port and a delivery port. The purging system also includes a pump assembly that is fluidly connected to the supply port of the metering valve. The pump assembly includes a pump and a single supply line that is fluidly connectable with a diesel exhaust fluid source. The purging system further includes an injection assembly that is fluidly connected to the delivery port of the metering valve. The injection assembly includes an air supply line that is fluidly connectable with an air supply source. Additionally, the purging system includes a controller in electrical communication with the metering valve, the pump assembly, and the injection assembly. The controller is configured to purge the pump assembly of residual diesel exhaust fluid using air from the air supply line. | 02-11-2016 |
Siyuan Zhang, Granger, IN US
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20150360224 | MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR EVALUATING TISSUE SAMPLES - A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber. | 12-17-2015 |
20150362411 | MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR IMAGING TISSUE SAMPLES - One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel. The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet channel can be fluid communication with the tissue chamber. The liquid outlet channel can be in fluid communication with the tissue chamber. The tissue chamber can be sized and dimensioned to completely immobilize the tissue sample during imaging. | 12-17-2015 |
Xishun Zhang, Carmel, IN US
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20130042793 | ASPHALT MODIFICATION PROCESSING SYSTEM AND METHOD FOR ASPHALT ADDITIVES - A process method for producing modified asphalt binder compositions that involves mixing an asphalt binder and at least one asphalt additive and/or asphalt modifier in a stirred ball mill so as to subject the mixture to mixing, shearing, impacting and grinding. | 02-21-2013 |
Yuetao Zhang, Columbus, IN US
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20080250773 | Control of filter regeneration - A system comprises an engine including an exhaust system with a particle filter operable to collect particulate matter in exhaust produced by the engine, a sensor arrangement, a controller, and one or more engine control devices. The sensor arrangement provides a first sensor signal representative of oxygen in the exhaust and a second sensor signal representative of a temperature of the particle filter. The controller regulates operation of the particle filter in response to the sensor arrangement. The controller is structured to generate one or more output signals corresponding to a minimum exhaust flow rate as a function of the first and second sensor signals. The control devices are responsive to the one or more output signals to provide the minimum exhaust flow rate to the filter. | 10-16-2008 |
20090308052 | METHODS OF INCREASING ACCURACY OF SOOT LOAD ESTIMATES - A method for improving the effectiveness of filters by increasing accuracy of an estimate of particulate matter loading remaining in the filter after cleaning. In one embodiment, the disclosed method includes removing soot from the DPF by cleaning, and measuring parameters for a set of predetermined criteria. The amount of soot present in the DPF is then estimated based on delta pressure. The resulting estimated soot load value accounts for the noise factors such as ash loading after extended operation. The value is then used to adjust for future measurements of soot loading in the DPF after subsequent regeneration treatments and/or used to diagnose the effectiveness of the cleaning. The method can also be applied to diagnostics of the DPF. When discrepancies between DPSLE and model-based soot load estimate are observed in healthy regenerations, failure modes such as plugged filter, extreme ash loading or substrate melting can be detected. | 12-17-2009 |
20110047966 | APPARATUS, SYSTEM, AND METHOD FOR DIESEL EXHAUST FLUID HEATING CONTROL - According to one embodiment, an apparatus for controlling the heating of diesel exhaust fluid (DEF) in a DEF delivery system includes a temperature comparison module that compares a difference between a sensed ambient air temperature and a sensed DEF tank temperature with a predetermined temperature difference threshold. Additionally, the apparatus includes a DEF heating status module that is configured to generate a DEF heating command according to (i) the sensed ambient air temperature if the difference between the sensed ambient air temperature and sensed DEF tank temperature is less than the predetermined temperature threshold; and (ii) the sensed DEF tank temperature if the difference between the sensed ambient air temperature and sensed DEF tank temperature is more than the predetermined temperature threshold. The apparatus also includes a DEF heating control module that is configured to control the heating of the DEF according to the DEF heating command. | 03-03-2011 |
20110113756 | System, method and apparatus for fuel injector diagnostics - A method includes providing a system having a fluid flow, a fuel injector and an oxygen sensor disposed in the fluid flow, where the oxygen sensor is downstream of the fuel injector. The method includes determining a first air fuel ratio, changing an injection rate of the fuel injector and determining a second air fuel ratio, and determining a fault value for the fuel injector from the first air fuel ratio and the second air fuel ratio. The method further includes determining the fault value for the fuel injector by determining a difference between the first air fuel ratio and the second air fuel ratio, and by determining that the fault value is positive in response to the difference being lower than a passing threshold value. The method includes changing injection rates of the fuel injector for specified periods of time short enough to significant disruption of system temperatures. | 05-19-2011 |
20120167554 | HYBRID ENGINE AFTERTREATMENT THERMAL MANAGEMENT STRATEGY - A system includes an internal combustion engine producing exhaust gases as a byproduct of operation and an aftertreatment system that treats the exhaust gases. The system further includes a controller that is structured to functionally execute operations to enhance the temperature of the aftertreatment system. The controller includes an operating condition monitoring module that interprets a temperature value at a position upstream of a catalyst positioned in the aftertreatment system. The controller further includes an operating condition management module that interprets a threshold temperature value, and an engine management module that provides an engine operation command to continue engine operation in response to the temperature value being at least equal to the threshold temperature value. | 07-05-2012 |
20150285172 | HYBRID ENGINE AFTERTREATMENT THERMAL MANAGEMENT STRATEGY - A system includes an internal combustion engine producing exhaust gases as a byproduct of operation and an aftertreatment system that treats the exhaust gases. The system further includes a controller that is structured to functionally execute operations to enhance the temperature of the aftertreatment system. The controller includes an operating condition monitoring module that interprets a temperature value at a position upstream of a catalyst positioned in the aftertreatment system. The controller further includes an operating condition management module that interprets a threshold temperature value, and an engine management module that provides an engine operation command to continue engine operation in response to the temperature value being at least equal to the threshold temperature value. | 10-08-2015 |
Zhaorui Zhang, West Lafayette, IN US
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20140316108 | Protein Chromatography Matrices with Hydrophilic Copolymer Coatings - A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples. | 10-23-2014 |
Zhen-Du Zhang, Carmel, IN US
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20130085109 | METHODS OF CARDIOVASCULAR PATIENT TREATMENT USING SUBSTANCES SUFFICIENT TO REDUCE ACTIN DEPOLYMERIZATION - Methods of cardiovascular patient treatment using substances sufficient to reduce actin depolymerization. In an exemplary embodiment of a method of treating a patient of the present disclosure, the method comprises the step of administering a therapeutically effective dose of a substance that reduces actin depolymerization within a vasculature of a patient to treat a cardiovascular condition of the patient. In at least one embodiment, the substance the substance is selected from the group consisting of jasplakinolide, Jasplaskinolide V, and Amphidinolide H. | 04-04-2013 |
Zhiping Zhang, West Lafayette, IN US
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20150041638 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 02-12-2015 |
Zhongnan Zhang, Zionsville, IN US
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20140007304 | GENES AND SNP MARKERS FOR APHID RESISTANT GENES FROM SOYBEAN LINES PI 567541B, PI567543C, AND PI 567598B | 01-02-2014 |
20140196167 | NEW SOURCES OF APHID RESISTANCE IN SOYBEAN PLANTS - The present invention relates to compositions and methods for identifying and using new germplasm providing aphid resistant in soybean plants, particularly for use in breeding soybean plant lines and cultivars representing specific set(s) of germplasm. In particular, aphid resistant soybean plants comprising new sources of germplasm and stacked germplasm/genes conferring enhanced aphid resistance are provided. These enhanced aphid resistant plants find use in breeding soybean plant lines (cultivars) including lines having superior aphid resistance. Further, the inventions relate to providing new aphid resistant germplasm identified by markers associated with plants having decreased damage from aphid feeding, as well as plants having enhanced tolerance to aphid infestation. Even further, the invention relates to compositions and methods for using genetic markers in breeding methods for producing plants and plant cultivars having increased resistance to aphid damage and increased tolerance to aphids, while retaining and acquiring desired agronomic traits. | 07-10-2014 |
Zhong-Yin Zhang, Carmel, IN US
Patent application number | Description | Published |
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20120088720 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES - Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals. | 04-12-2012 |
20140179735 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS - A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors of | 06-26-2014 |
20150239931 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES - Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds for inhibiting a PTP enzyme (such as PTP-MEG2), as well as treating a disease, disorder, or condition associated with inappropriate activity of a PTP (such as type 2 diabetes), is also provided. | 08-27-2015 |
20160102054 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) - Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of Src homology 2-domain containing protein tyrosine phosphatase-2. | 04-14-2016 |
Zhong-Yin Zhang, Indianapolis, IN US
Patent application number | Description | Published |
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20110281942 | Tautomycetin and Tautomycetin Analog Biosynthesis - The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function. | 11-17-2011 |