Patents - stay tuned to the technology

Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Zhang, CO

Chenxi Zhang, Boulder, CO US

Patent application numberDescriptionPublished
20140301937FULLERENE SEPARATION THROUGH USE OF ORGANIC CAGES - Provided herein are compositions useful in the separation of fullerenes from a mixture comprising fullerenes. Also provided herein are methods of making the compositions, as well as methods of using the compositions for fullerene separation.10-09-2014

Chuang Zhang, Fort Collins, CO US

Patent application numberDescriptionPublished
20160118893CIRCUITS AND METHODS PROVIDING DEAD TIME ADJUSTMENT AT A SYNCHRONOUS BUCK CONVERTER - An apparatus and method are disclosed for efficiently using power at a voltage regulator, such as a synchronous buck converter. The synchronous buck converter includes a first switch and a second switch operated by a first control signal and a second control signal, respectively, where the first and second control signals have a corresponding phase difference. A logic circuit measures a duty cycle of an input pulse width modulated (PWM) signal against iterative changes of the phase difference between the first control signal and the second control signal. The logic circuit selects a phase difference corresponding to a minimum value of the PWM signal, thereby optimizing dead time at the synchronous buck converter. The logic circuit may include a Digital Pulse Width Modulator.04-28-2016

Gan Zhang, Niwot, CO US

Patent application numberDescriptionPublished
20130203681Macrocyclic Compounds Useful as Inhibitors of Histone Deacetylases - The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.08-08-2013
20140057844CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF - The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.02-27-2014
20140194403METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS - Provided herein are methods for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal, which comprises administering to said mammal in need thereof a therapeutically effective amount of a compound of Formula I:07-10-2014
20150238562BOURVADIN DERIVATIVES AND THERAPEUTIC USES THEREOF - The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.08-27-2015
20150343016CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF - The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.12-03-2015

Patent applications by Gan Zhang, Niwot, CO US

Gan Zhang, Longmont, CO US

Patent application numberDescriptionPublished
20090047246NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.02-19-2009

Gan Zhang, Boulder, CO US

Patent application numberDescriptionPublished
20110166122SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS - Compounds of Formula (I): in which R07-07-2011
20110195948Substituted Pyrazolo[1,5-a]Pyrimidine Compounds as TRK Kinase Inhibitors - Compounds of Formula (I) in which R08-11-2011
20130217662METHOD OF TREATMENT USING SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS - Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I08-22-2013
20150133429METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS - Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or 05-14-2015

Patent applications by Gan Zhang, Boulder, CO US

Gongyi Zhang, Denver, CO US

Patent application numberDescriptionPublished
20080306000Three-Dimensional Structures of TALL-1 and its Cognate Receptors and Modified Proteins and Methods Related Thereto - Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods.12-11-2008
20120165274THREE-DIMENSIONAL STRUCTURES OF TALL-1 AND ITS COGNATE RECEPTORS AND MODIFIED PROTEINS AND METHODS RELATED THERETO - Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods.06-28-2012

Patent applications by Gongyi Zhang, Denver, CO US

Haipeng Zhang, Longmont, CO US

Patent application numberDescriptionPublished
20120126122HIGH REPETITION RATE PHOTOCONDUCTIVE TERAHERTZ EMITTER USING A RADIO FREQUENCY BIAS - A terahertz generation system that emits pulsed THz radiation and incorporates a rapidly oscillating, high voltage bias across electrodes insulated from a photoconductive material. The system includes an ultrafast optical pulse source configured to generate an optical pulse having a duration between about ten picoseconds and ten femtoseconds, the pulse further having a repetition rate of about one megahertz or higher. The system further includes a photoconductor configured to receive the optical pulse from the ultrafast optical pulse source and to generate a terahertz frequency pulse, the photoconductor having insulated electrodes. The system still further includes a radio frequency generator configured to apply an electric field to the photoconductor via the insulated electrodes.05-24-2012

Haotian Zhang, Longmont, CO US

Patent application numberDescriptionPublished
20110075718Automatic Filter-Reset Mechanism - In one embodiment, a (hard-drive) read channel has a (DFIR equalization) filter, whose tap coefficients are adaptively updated. A reset controller monitors an (LLR) signal generated downstream of the filter to automatically determine when to reset the filter, e.g., by reloading an initial set of user-specified tap coefficients. For LLR values, the reset controller determines to reset the filter when the reset controller detects that too many recent LLR values have confidence values that are too low. When implemented in a hard-drive read channel, the reset controller can reset the filter one or more times during read operations within a sector of the hard drive.03-31-2011
20120068752Systems and Methods for Low Latency Noise Cancellation - Various embodiments of the present invention provide systems and methods for data processing. For example, a data processing circuit is discussed that includes a data detector circuit, a detector mimicking circuit, and an error calculation circuit. The data detector circuit is operable to perform a data detection process on a first signal derived from a data input to yield a detected output. The data mimicking circuit is operable to process a second signal derived from the data input to yield a mimicked output. The error calculation circuit is operable to calculate a difference between the second signal and a third signal derived from the mimicked output to yield a feedback signal. The feedback signal is operable to modify the data input during a subsequent period.03-22-2012
20120068870Systems and Methods for Semi-Independent Loop Processing - Various embodiments of the present invention provide systems and methods for data processing. For example, a data processing circuit is discussed that includes an analog to digital converter circuit, a digital filter circuit, a data detector circuit, a mimic filter circuit, and a sample clock generation circuit. The analog to digital converter circuit is operable to receive a data input and to provide corresponding digital samples. The digital filter circuit is operable to receive the digital samples and to provide a filtered output. The data detector circuit is operable to perform a data detection process on the filtered output to yield a detected output. The mimic filter circuit is operable to receive the digital samples and to provide a mimicked output. The sample clock generation circuit is operable to provide a sample clock based at least in part on the detected output and the mimicked output.03-22-2012
20120069891Systems and Methods for Filter Constraint Estimation - Various embodiments of the present invention provide systems and methods for calibrating a data processing circuit. For example, a method for calibrating a data processing circuit is discussed that includes providing a digital filter, providing a detector circuit, and providing an analog filter. Operation of the digital filter is at least in part governed by filter taps that correspond to a filter tap constraint value. Operation of the detector circuit is at least in part governed by a target parameter. Operation of the analog filter is at least in part governed by an analog parameter that is one of a plurality of analog parameters. The methods further include selecting a target parameter, and calculating the filter tap constraint value based on the target parameter. Combinations of the target parameter, the calculated filter tap constraint value, and each of the plurality of analog parameters are applied to identify the analog parameter.03-22-2012
20120124454Systems and Methods for ADC Sample Based Timing Recovery - Various embodiments of the present invention provide systems and methods for data processing. For example, a data processing circuit is discussed that includes an analog to digital converter circuit operable to receive a data input and to provide corresponding digital samples, and a digital filter circuit operable to receive the digital samples and to provide a filtered output. A data detector circuit is operable to perform a data detection process on the filtered output to yield a detected output, and a phase detector circuit operable to calculate an error feedback value based at least in part on the detected output and the digital samples.05-17-2012
20120212851Systems and Methods for Medium Contact Detection - Various embodiments of the present invention provide systems and methods for detecting contact. For example, a method for detecting head contact is disclosed that includes: receiving an interface signal operable to indicate a physical contact between a sensing device and a storage medium; band pass filtering a data set derived from the interface signal to yield a band pass filtered output; comparing the band pass filtered output to a level threshold to yield a comparator output; summing the comparator output with at least one prior instance of the comparator output to yield an aggregated value; and comparing the aggregated value to an aggregate threshold to yield a contact output.08-23-2012
20130050005Read Channel With Oversampled Analog To Digital Conversion And Parallel Data Detectors - Methods and apparatus are provided for processing a signal in a read channel using a selective oversampled analog to digital conversion. The disclosed selective oversampled analog to digital conversion simplifies the analog design by transferring at least a portion of the equalization and/or filtering processes to the digital domain. An oversampled analog to digital conversion is applied to an analog input signal to generate a plurality of digital samples for a given bit interval. The plurality of digital samples for a given bit interval are applied to a corresponding plurality of data detectors to obtain a detected output. The plurality of digital samples for a given bit interval may have a phase offset relative to one another. The detected output may be obtained, for example, by summing the outputs of the plurality of data detectors or by aggregating weighted outputs of the plurality of data detectors.02-28-2013
20130097213Nyquist Constrained Digital Finite Impulse Response Filter - Various embodiments of the present invention provide apparatuses and methods for filtering a digital signal with a Nyquist constrained digital finite impulse response filter. For example, an apparatus for filtering digital data is disclosed that includes a digital finite impulse response filter having a plurality of taps. The apparatus also includes a tap weight controller connected to the digital finite impulse response filter, operable to adjust a tap weight for each of a subset of the taps such that a magnitude of a Nyquist response of the digital finite impulse response filter remains within a constraint range.04-18-2013
20130124949Systems and Methods for Post Processing Gain Correction - Various embodiments of the present invention provide circuits, systems and methods for data processing. For example, a data processing system is disclosed that includes: a data detector circuit, a filter circuit, a gain error generation circuit, and a multiplier circuit. The data detector circuit is operable to apply a data detection algorithm to a data set to yield a detected output. The filter circuit is operable to filter the detected output to yield a filtered output. The gain error generation circuit is operable to calculate an error value based upon a combination of an instance of the data set and a corresponding instance of the filtered output. The multiplier circuit operable to multiply the instance of the data set by a gain feedback value to yield a gain corrected output. The gain feedback value is derived from the error value.05-16-2013
20140029128Saturation-Based Loop Control Assistance - The present inventions are related to systems and methods for data processing, and more particularly to data processing using distortion-correction loops with saturation-based assistance.01-30-2014
20140036385ZERO GAIN START BIAS ESTIMATION - A method and system for estimating a zero gain start (ZGS) bias in a read channel is disclosed. The method may include: receiving preamble samples within a fixed-length window selected for ZGS calculation; calculating an energy associated with a 2T frequency in the preamble samples; calculating an energy associated with non-2T frequencies in the preamble samples; and calculating the ZGS bias based on the energy associated with the 2T frequency in the preamble samples and the energy associated with non-2T frequencies in the preamble samples.02-06-2014
20140104717ZERO GAIN START AND GAIN ACQUISITION BASED ON ADAPTIVE ANALOG-TO-DIGITAL CONVERTER TARGET - Aspects of the disclosure pertain to a system and method for providing zero gain start (ZGS) and gain acquisition based on an adaptive analog-to-digital converter (ADC) target. The adaptive ADC target is used to collect channel characteristics and based on the adaptive ADC target, an adjusted 2T amplitude target value is generated.04-17-2014
20140149796Systems and Methods for Controlled Data Processor Operational Marginalization - Systems, methods, devices, circuits for data processing, and more particularly to data processing including operational marginalization capability.05-29-2014
20140160592Systems and Methods for X-Sample Based Data Processor Marginalization - Systems, methods, devices, circuits for data processing, and more particularly to data processing including operational marginalization capability.06-12-2014
20140168810Systems and Methods for Adaptive Threshold Pattern Detection - The present inventions are related to systems and methods for data processing, and more particularly to systems and methods for detecting patterns in a data stream.06-19-2014
20140211336AUTOMATIC GAIN CONTROL LOOP ADAPTATION FOR ENHANCED NYQUIST DATA PATTERN DETECTION - Techniques are provided for automatic gain control loop adaptation in circuitry for processing such data signals. In one example, an apparatus comprises read channel circuitry and signal processing circuitry associated with the read channel circuitry. The signal processing circuitry comprises an amplifier, a detector operatively coupled to the amplifier, and a feedback path operatively coupled between the detector and the amplifier. The amplifier is configured to receive and amplify an input signal received by the read channel circuitry. The detector is configured to detect a data pattern from the amplified input signal. The feedback path is configured to provide a feedback signal to the amplifier to adjust a gain of the amplifier, and to generate the feedback signal in accordance with a value selected to improve detection of the data pattern by increasing an amplitude of the data pattern around a given frequency.07-31-2014
20140254043SAMPLING-PHASE ACQUISITION BASED ON CHANNEL-IMPULSE-RESPONSE ESTIMATION - Embodiments of the invention can be manifested as methods for converting analog waveforms into digital sampled signals. In at least one such embodiment, the method includes (i) sampling, based on a sampling-clock signal, an analog waveform received from a transmission channel to generate a digital sampled signal, (ii) generating a digital target signal by applying a specified reference data pattern to a model of the transmission channel, and (iii) adjusting the sampling-clock signal by comparing the digital sampled signal to the digital target signal. Embodiments of the invention can also be manifested as apparatuses that convert analog waveforms into digital sampled signals.09-11-2014
20150187385Systems and Methods for Multi-Head Balancing in a Storage Device - Systems and method relating generally to data processing, and more particularly to systems and methods for utilizing multiple data streams for data recovery from a storage device.07-02-2015

Patent applications by Haotian Zhang, Longmont, CO US

Jian Zhang, Englewood, CO US

Patent application numberDescriptionPublished
20150357642LiwNixMnyOz SPINELS AND METHOD OF MAKING AND USING THE SAME - A process is provided for synthesizing a lithium, nickel, manganese and oxygen composition, Li12-10-2015

Jieyuan Zhang, Littleton, CO US

Patent application numberDescriptionPublished
20140073541SURFACTANTS FOR ENHANCED OIL RECOVERY - Surfactant compositions useful for oil recovery comprise from 10 to 80 wt. % of a prapoxylated C12-C20 alcohol sulfate, from 10 to 80 wt. % of a C12-C20 internal olefin sulfonate, and from 0.1 to 10 wt. % of an ethoxylated C4-C12 alcohol sulfate. A minor proportion of the ethoxylated alcohol sulfate reduces or eliminates the need to rely on costly cosolvents for achieving good performance in enhanced oil recovery processes. Low interfaoial tensions and low microemulsion viscosities can be achieved when the ethoxylated alcohol sulfate accompanies the propoxytated alcohol sulfate and internal olefin sulfonate. Aqueous concentrates comprising water and the surfactant compositions described above are also disclosed. Dilution of the surfactant composition or aqueous concentrate with water or brine to the desired anionic actives level provides an injectable composition useful for EOR applications. Stable, low-viscosity oil-in-water microemulsions comprising crude oil, water, and the surfactant compositions are also disclosed.03-13-2014

Jingchuan Zhang, Boulder, CO US

Patent application numberDescriptionPublished
20100197005HUMAN MONOCLONAL ANTIBODIES TO ACTIVIN RECEPTOR-LIKE KINASE-1 - The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.08-05-2010

Jiucai Zhang, Arvada, CO US

Patent application numberDescriptionPublished
20160101708SYSTEM AND METHOD FOR CALIBRATING BATTERY STATE OF CHARGE - The present disclosure is directed to a system and method for calibrating state-of-charge (SOC) of an energy storage device. The method includes monitoring, via a battery management system, at least one of an accumulated capacity of the energy storage device after a first SOC calibration or a time period after the first SOC calibration. Another step includes determining, via the battery management system, whether at least one of the accumulated capacity or the time period is above a predetermined threshold. If at least one of the accumulated capacity or the time period is above a predetermined threshold, then the method includes charging, via the battery management system, the energy storage device for a specified duration until the energy storage device reaches a second SOC calibration.04-14-2016

Jordan Zion Zhang, Westminster, CO US

Patent application numberDescriptionPublished
20140304678SYSTEM AND METHOD FOR RESOURCE-DEFINITION-ORIENTED SOFTWARE GENERATION AND DEVELOPMENT - A system and method for productively developing web services and associated client software to access web services across entire development lifecycle is disclosed. In various aspects, collections of resource definitions stored and managed in a repository and configured and published as network addressable/accessible resources, serve as a platform with application programming interfaces and/or user-interfaces to enable software professionals to continuously define, design, construct, test, publish and access web services.10-09-2014

Mingfu Zhang, Highlands Ranch, CO US

Patent application numberDescriptionPublished
20090275699Starch containing formaldehyde-free thermoset binders for fiber products - Binder compositions are described that include a carboxyl-containing polymer, a cross-linking agent, and a starch compound having a molecular weight greater than about 10,000 g/mol. In addition, fiber products are described that include mineral or polymeric fibers and a binder prepared from an aqueous composition that includes a carboxyl-containing polymer, a cross-linking agent, and a starch having a molecular weight greater than 10,000 g/mol.11-05-2009
20110166275FORMALDEHYDE-FREE BINDER COMPOSITIONS CONTAINING METAL-ION CROSSLINKERS AND PRODUCTS MADE THERE FROM - Formaldehyde-free binder compositions are described. The binder compositions may include a polycarboxy compound, and an organic crosslinking agent, and a polyvalent metal compound. The compositions may also optionally include a cure catalyst. In addition, composite materials are described. The composite materials may include a mat of fibers and a binder composition. The binder composition may include a polycarboxy compound, an organic crosslinking agent, and a polyvalent metal compound.07-07-2011
20110189479FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDER COMPOSITIONS - One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.08-04-2011
20110268915FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDER COMPOSITIONS - A wood-containing composite are described that may include a lignocellulosic material, and a formaldehyde-free binder in contact with at least a portion of the lignocellulose material. The binder is formed from a binder composition that includes a soy flour, a polymer, and a crosslinking agent, at least a portion of each of which are covalently crosslinked to each other in the binder. Also described are methods of making wood-containing composites by providing a pre-mixed, one-part binder composition of at least 60 wt. % soy flour, a polymer, and a crosslinking agent. The binder composition is applied to lignocellulosic material, and the combination may be heated at a temperature of about 100° C. or more to cure the binder composition into a binder. The cured binder has the soy protein, polymer, and crosslinking agent covalently bonded to each other.11-03-2011
20120058701FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDERS FOR SPUNBOND PRODUCTS - One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.03-08-2012
20120156953CURABLE FIBERGLASS BINDER COMPRISING SALT OF INORGANIC ACID - A curable formaldehyde-free binding composition for use with fiberglass is provided. Such curable composition comprises an aldehyde or ketone and an amine salt of an inorganic acid. The composition when applied to fiberglass is cured to form a water-insoluble binder which exhibits good adhesion to glass. In a preferred embodiment the composition when applied to fiberglass provides a sufficient blackness required in facer products.06-21-2012
20130130582MODIFIED UREA-FORMALDEHYDE BINDERS FOR NON-WOVEN FIBER GLASS MATS - Urea-formaldehyde (UF) resin binder compositions modified with a starch are described. The binder compositions may include about 1 wt. % to about 10 wt. % of a starch. In addition, fiber reinforced composites are described. The composites may include organic or inorganic fibers and a polymer matrix formed from a binder composition. The binder composition may include a UF resin and about 1 wt. % to about 10 wt. % of a starch.05-23-2013
20130231023FORMALDEHYDE-FREE PROTEINACEOUS BINDER COMPOSITIONS - Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.09-05-2013
20140134497SOY PROTEIN AND CARBOHYDRATE CONTAINING BINDER COMPOSITIONS - Soy protein and carbohydrate containing binder compositions are described. The binder compositions may include a carbohydrate, a nitrogen-containing compound, and a soy protein. The binder compositions may also optionally include thickening agents such as modified celluloses and polysaccharides.05-15-2014
20140134909VISCOSITY MODIFIED FORMALDEHYDE-FREE BINDER COMPOSITIONS - Viscosity-modified carbohydrate binder compositions are described. The binder compositions may include a carbohydrate, a nitrogen-containing compound, and a thickening agent. The binder compositions may have a Brookfield viscosity of 7 to 50 centipoise at 20° C. The thickening agents may include modified celluloses such as hydroxyethyl cellulose (HEC) and carboxymethyl cellulose (CMC), and polysaccharides such as xanthan gum, guar gum, and starches.05-15-2014
20140256201FIBER REINFORCED COMPOSITES MADE WITH COUPLING-ACTIVATOR TREATED FIBERS AND ACTIVATOR CONTAINING REACTIVE RESIN - This invention relates to a process of making a fiber-reinforced composite. Glass fibers may be provided. These glass fibers may be treated with a sizing composition that has a coupling-activator compound with the formula: S—X-(A)09-11-2014
20140329936FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDER COMPOSITIONS - One-part thermosetting binder compositions are described that may include soy protein, a first crosslinking compound, and a second crosslinking compound different from the first crosslinking compound. Upon curing, the first and second crosslinking compounds covalently bond to each other and to the soy protein to form a thermoset binder. Also describe are fiber-containing products that include a plurality of fibers and a formaldehyde-free binder. The formaldehyde-free binder is formed from a one-part, thermosetting binder composition that includes soy protein, a first crosslinking compound, and a second crosslinking compound different from the first crosslinking compound. Upon curing, the first and second crosslinking compounds covalently bond to each other and to the soy protein to form a thermoset binder.11-06-2014
20140364025FIBER-REINFORCED COMPOSITE ARTICLES AND METHODS OF MAKING THEM - Methods of making prepregs are described. The methods include the steps of forming a fiber-containing substrate, and contacting the fiber-containing substrate with a resin mixture. The resin mixture may include polymer particles mixed in a liquid medium, and the polymer particles may be coated on the fiber-containing substrate to form a coated substrate. The liquid medium may be removed from the coated substrate to form the prepreg. The prepregs may be used to make fiber-reinforced articles.12-11-2014
20150017546FORMALDEHYDE FREE BINDER COMPOSITIONS CONTAINING METAL ION CROSSLINKERS AND PRODUCTS MADE THEREFROM - Formaldehyde-free binder compositions are described. The binder compositions may include a polycarboxy compound, and an organic crosslinking agent, and a polyvalent metal compound. The compositions may also optionally include a cure catalyst. In addition, composite materials are described. The composite materials may include a mat of fibers and a binder composition. The binder composition may include a polycarboxy compound, an organic crosslinking agent, and a polyvalent metal compound.01-15-2015
20150024647CURABLE FIBERGLASS BINDER COMPRISING SALT OF INORGANIC ACID - A curable formaldehyde-free binding composition for use with fiberglass is provided. Such curable composition comprises an aldehyde or ketone and an amine salt of an inorganic acid. The composition when applied to fiberglass is cured to form a water-insoluble binder which exhibits good adhesion to glass. In a preferred embodiment the composition when applied to fiberglass provides a sufficient blackness required in facer products.01-22-2015
20150031259FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDER COMPOSITIONS - One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.01-29-2015
20150050857FORMALDEHYDE-FREE PROTEINACEOUS BINDER COMPOSITIONS - Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.02-19-2015
20150087783FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDERS FOR SPUNBOND PRODUCTS - One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.03-26-2015
20150144253FIBER-CONTAINING PREPREGS AND METHODS AND SYSTEMS OF MAKING - Methods of making a fiber-containing prepregs may include drawing unsized fibers from a batch of molten glass. The method may also include applying a sizing composition to the unsized fibers to form a plurality of sized fibers, where the sizing composition includes a first polymerization agent for polymerizing caprolactam. The method may further include weaving the plurality of sized fibers into a fabric. Another step may include melting a reactive resin composition to form a melted reactive resin composition, where the reactive resin composition may include caprolactam. The melted reactive resin composition may be applied to the fabric. The method may further include heating the fabric and the melted reactive resin composition to a polymerization temperature, where the caprolactam polymerizes to form a fiber-resin amalgam including a polyamide. Another step may be to form the fiber-resin amalgam into the fiber-containing prepreg.05-28-2015
20150145165FIBER-CONTAINING PREPREGS AND METHODS AND SYSTEMS OF MAKING - Methods of making fiber-containing prepregs are described. The methods may include the steps of providing a plurality of fibers, and applying a reactive resin composition to the plurality of fibers to make a mixture of the plurality of fibers and the resin composition. The reactive resin composition may include at least one of monomers and oligomers capable of polymerizing into a polymerized resin matrix. The mixture may be heated to a polymerization temperature where the monomers, oligomers, or both polymerize to form a fiber-resin amalgam that includes the polymerized resin matrix. The fiber-resin amalgam may be formed into the fiber-containing prepreg. Also described are methods of forming a fiber-reinforced composite that includes the prepreg.05-28-2015
20150148485FIBER-REINFORCED COMPOSITES MADE WITH REACTIVE RESIN COMPOSITIONS AND FIBERS - Methods of making fiber-resin compositions are described. The method may include the providing of a reactive resin composition to an extruder, where the reactive resin composition may include monomers, oligomers, or both, that are capable of polymerizing into a thermoplastic resin. The method may further include combining the reactive resin composition with a plurality of reactive fibers that are also supplied to the extruder. The plurality of reactive fibers may be sized with at least one polymerization agent and/or coupling agent. The fiber-resin composition may be extruded from the extruder, where the composition includes a thermoplastic resin in contact with the plurality of fibers that is formed by the polymerization of the monomers and/or oligomers of the reactive resin composition. Also described are methods of making fiber-reinforced composite articles from the fiber-resin composition.05-28-2015
20150148498FIBER-REINFORCED COMPOSITES MADE WITH THERMOPLASTIC RESIN COMPOSITIONS AND REACTIVE COUPLING FIBERS - Methods of making fiber-resin compositions are described. The methods may include the providing of a thermoplastic resin to an extruder, where the thermoplastic resin may include at least one reactive moiety capable of forming a covalent bond with a coupling agent on a plurality of reactive fibers. The methods may further include combining the thermoplastic resin with the plurality of reactive fibers also supplied to the extruder. The reactive fibers are sized with the coupling agent that reacts with the thermoplastic resin to form the fiber-resin composition, which may be extruded from the extruder. Methods of making fiber-reinforced composite articles from the fiber-resin composition are also described.05-28-2015
20150283577WATER SPRAY APPLIED LOOSE-FILL INSULATION - According to an embodiment, a method of applying loose-fill insulation within a cavity is provided. The method includes blowing loose-fill insulation particles into a cavity of a structure to install the loose-fill insulation within the cavity and thereby insulate the structure. The method also includes applying water (e.g., water mist) to the loose-fill insulation particles so that a moisture content of the installed loose-fill insulation is between about 2% and 20%. The water aids in retaining the loose-fill insulation particles within the cavity without requiring the use of an enclosure member that encloses the cavity and the loose-fill insulation is substantially free of a water soluble adhesive material that adheres the loose-fill insulation particles together within the cavity.10-08-2015
20160024266FIBER-CONTAINING PREPREGS AND METHODS AND SYSTEMS OF MAKING - Methods of making a fiber-containing prepregs may include drawing unsized fibers from a batch of molten glass. The method may also include applying a sizing composition to the unsized fibers to form a plurality of sized fibers, where the sizing composition includes a first polymerization agent for polymerizing caprolactam. The method may further include weaving the plurality of sized fibers into a fabric. Another step may include melting a reactive resin composition to form a melted reactive resin composition, where the reactive resin composition may include caprolactam. The melted reactive resin composition may be applied to the fabric. The method may further include heating the fabric and the melted reactive resin composition to a polymerization temperature, where the caprolactam polymerizes to form a fiber-resin amalgam including a polyamide. Another step may be to form the fiber-resin amalgam into the fiber-containing prepreg.01-28-2016
20160046107SIZED GLASS FIBERS FOR FIBER-CONTAINING COMPOSITE ARTICLES AND METHODS OF MAKING THEM - Methods of making prepregs are described. The methods include the steps of forming a fiber-containing substrate, and contacting the fiber-containing substrate with a resin mixture. The resin mixture may include polymer particles mixed in a liquid medium, and the polymer particles may be coated on the fiber-containing substrate to form a coated substrate. The liquid medium may be removed from the coated substrate to form the prepreg. The prepregs may be used to make fiber-reinforced articles.02-18-2016
20160102182FIBER-REINFORCED COMPOSITE ARTICLES AND METHODS OF MAKING THEM - Methods of making a prepreg are described. The methods include the steps of forming a fiber-containing substrate, and contacting the fiber-containing substrate with a resin mixture. The resin mixture may include particles of monomers or oligomers mixed in a liquid medium, and the particles may be coated on the fiber-containing substrate to form a coated substrate. The liquid medium may be removed from the coated substrate to form the prepreg. The prepregs may be used to make fiber-reinforced articles.04-14-2016
20160108189FIBER REINFORCED THERMOSET COMPOSITES AND METHODS OF MAKING - Methods of making a fiber-reinforced composite are described. The methods may include applying a sizing composition to a plurality of fibers to make sized fibers, where the sizing composition may include at least one of a curing agent or an accelerator for a resin composition. The sized fibers may be contacted with the resin composition to form a resin-fiber amalgam, where the resin composition includes 50 wt. % or less of a total amount of the curing agent and the accelerator that is also present on the sized fibers. The resin-fiber amalgam may then be cured to form the fiber-reinforced composite.04-21-2016

Patent applications by Mingfu Zhang, Highlands Ranch, CO US

Mingfu Zhang, Highland Ranch, CO US

Patent application numberDescriptionPublished
20120156954CURABLE FIBERGLASS BINDER - A curable formaldehyde-free binding composition for use with fiberglass is provided. Such curable composition comprises an addition product of an amine and a reactant to form an amino-amide intermediate. To the amino-amide is added an aldehyde or ketone to form the curable binder composition. The composition when applied to fiberglass is cured to form a water-insoluble binder which exhibits good adhesion to glass. In a preferred embodiment the composition when applied to fiberglass provides a sufficient blackness required in facer products.06-21-2012
20160108188FIBER REINFORCED THERMOPLASTIC COMPOSITES AND METHODS OF MAKING - Methods of making a fiber-reinforced thermoplastic polyurethane composite are described. The methods may include applying a sizing composition to a plurality of fibers to make sized fibers, where the sizing composition may include at least one curative for a thermoplastic polyurethane prepolymer. The sized fibers may be contacted with a thermoplastic polyurethane prepolymer composition to form a resin-fiber amalgam, where the thermoplastic polyurethane prepolymer composition includes 50 wt. % or less of a total amount of the curative that is also present on the sized fibers. The resin-fiber amalgam may then be cured to form the fiber-reinforced thermoplastic polyurethane composite.04-21-2016

Qinghong Zhang, Englewood, CO US

Patent application numberDescriptionPublished
20130267456THERAPEUTIC APPLICATIONS OF SMAD7 - The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.10-10-2013
20140288006PTD-SMAD7 THERAPEUTICS - The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.09-25-2014
20150290287THERAPEUTIC APPLICATIONS OF SMAD7 - The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systematically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.10-15-2015
20160039894PTD-SMAD7 THERAPEUTICS - The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.02-11-2016

Patent applications by Qinghong Zhang, Englewood, CO US

Ruichong Zhang, Golden, CO US

Patent application numberDescriptionPublished
20130255667SOLID PARTICLE THERMAL ENERGY STORAGE DESIGN FOR A FLUIDIZED-BED CONCENTRATING SOLAR POWER PLANT - A fluidized-bed concentrating solar power plant comprises a particle receiver configured to contain solid state particles, wherein the particle receiver heats the solid state particles by transferring thermal energy from sunlight to the solid state particles. The plant also comprises a first silo configured to receive and store heated solid state particles from the particle receiver; a heat exchanger configured to receive the heated solid state particles from the first silo and generate a fluidized mixture comprising the heated solid state particles suspended in a gas; and a second silo configured to feed cooled solid state particles to the particle receiver, the cooled solid state particle extracted from the fluidized mixture. The first silo and the second silo each comprise a foundation comprising a base supported by a plurality of micropile units. Each micropile unit comprises a plurality of micropile columns coupled to a support block which supports the base.10-03-2013

Tianhua Zhang, Superior, CO US

Patent application numberDescriptionPublished
20110319043Signal Degradation Detection - Implementations are directed to predicting signal degradation at receivers used to display a programming service. The receivers capture signal strength data that is then transmitted to a processing location, which may be associated with a provider of the programming service. A signal degradation detector at the provider operates to predict whether or not a future unacceptable signal quality will occur within a time interval. The prediction may be based on a test quantity calculated from signals captured at the receiver and based on a figure of merit for the geographic locale in which the receiver is located. A maintenance call may be initiated for those receivers that have such a poor signal quality.12-29-2011
20130109336SIGNAL DEGRADATION DETECTION05-02-2013

Tianxi Zhang, Fort Collins, CO US

Patent application numberDescriptionPublished
20110263002COMPOSITIONS AND METHODS FOR CONTINUOUS HARVESTING OF SUSPENSION GROWTH CULTURES - Embodiments herein concern compositions, methods and uses for harvesting suspension cultures or decontaminating waters. In certain embodiments, suspension microorganism cultures can comprise algal cultures. In some embodiments, harvesting suspension cultures may include using a composition capable of interacting with the culture in order to separate the culture from a liquid or media.10-27-2011
20130273630COMPOSITIONS AND METHODS FOR CONTINUOUS HARVESTING OF SUSPENSION GROWTH CULTURES - Embodiments herein concern compositions, methods and uses for harvesting suspension cultures or decontaminating waters. In certain embodiments, suspension microorganism cultures can comprise algal cultures. In some embodiments, harvesting suspension cultures may include using a composition capable of interacting with the culture in order to separate the culture from a liquid or media.10-17-2013

Tina Zhang, Parker, CO US

Patent application numberDescriptionPublished
20110032172NONCONDUCTIVE ANTENNA MOUNT - An antenna mount is disclosed. The antenna mount includes a mast and a foot that are substantially free of electrically conductive elements. The mast has a first end having a circular cross-section configured to be received by a mounting bracket of a satellite dish having a circular interior cross-section. The foot is configured to be secured to a stationary mounting surface and to be pivotally attached to a second end of the mast.02-10-2011

Wei Zhang, Superior, CO US

Patent application numberDescriptionPublished
20110284063HIGH EFFICIENCY DYE-SENSITIZED SOLAR CELL WITH LAYERED STRUCTURES - A dye-sensitized solar cell (DSSC) is provided. The DSSC anode includes a first electron-collecting layer deposited on a substrate and a first electron-transporting layer deposited on the first electron-collecting layer, the first electron-transporting layer containing light-absorbing dye. The DSSC anode also includes a second nanoporous electron-collecting layer deposited on the first electron-transporting layer; and a second electron-transporting layer deposited on the second porous electron-collecting layer, the second electron-transporting layer containing light-absorbing dye. Methods of fabricating the DSSC anode are also provided.11-24-2011
20130261295Highly Active Multidentate Catalysts for Efficient Alkyne Metathesis - The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogues.10-03-2013
20140212575Novel Self-Assembling Nanocomposite Structures and Methods of Preparing Same - The present invention includes a novel self-assembling nanocomposite structure comprising a shape-persistent three-dimensional cage molecule. In one aspect, binding of nanoparticles to metal coordinating groups in the cage molecule allows for the self-assembly of the nanoparticles into a nanocomposite material. The present invention further includes methods of preparing such self-assembling nanocomposite structures.07-31-2014
20140301937FULLERENE SEPARATION THROUGH USE OF ORGANIC CAGES - Provided herein are compositions useful in the separation of fullerenes from a mixture comprising fullerenes. Also provided herein are methods of making the compositions, as well as methods of using the compositions for fullerene separation.10-09-2014
20150259458NOVEL COVALENTLY CROSS-LINKED MALLEABLE POLYMERS AND METHODS OF USE - Disclosed herein are compositions and methods of making novel covalently cross-linked polyimines that non-malleable under standard conditions but yet may be rendered malleable.09-17-2015
20150273457HIGHLY ACTIVE MULTIDENTATE CATALYSTS FOR EFFICIENT ALKYNE METATHESIS - The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogues.10-01-2015

Patent applications by Wei Zhang, Superior, CO US

Weichang Zhang, Greenwood Village, CO US

Patent application numberDescriptionPublished
20120136673METHODS, APPARATUSES AND COMPUTER PROGRAM PRODUCTS FOR DETERMINING CHANGES IN LEVELS OF CARE FOR PATIENTS - An apparatus is provided for determining a change in a level of care for a patient(s). The apparatus includes at least one memory and at least one processor configured to determine that at least one of an admission of a patient to a health care facility, a discharge of the patient from the health care facility, or a transfer of the patient within the health care facility triggered a level of care change event associated with the patient. The processor is also configured to identify a care event(s) for the patient in response to determining that the level of care change event was triggered. The processor is also configured to generate a notification(s) to perform a task(s) associated with the care event(s) for the patient and associate the care event(s) and a task(s) with the triggered level of care change event. Corresponding computer program products and methods are also provided.05-31-2012

Weiming Zhang, Aurora, CO US

Patent application numberDescriptionPublished
20160060701METHODS FOR PREDICTING RISK OF INTERSTITIAL PNEUMONIA - Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.03-03-2016

Xianghua Zhang, Auroroa, CO US

Patent application numberDescriptionPublished
20150093831CONSTRUCTION OF FULLY-DELETED ADENOVIRUS-BASED GENE DELIVERY VECTORS AND USES THEREOF - The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector includes (a) providing an Adenovirus packaging cell line; (b) transfecting a fully-deleted Adenoviral vector construct into the cell line; and optionally (c) transfecting a packaging construct into the cell line, wherein the fully-deleted Adenoviral vector construct and optionally the packaging construct can transfect the Adenovirus packaging cell line resulting in the encapsidation of a fully-deleted Adenoviral vector independent of helper Adenovirus. In an embodiment, a target cell is transduced with the encapsidated fully-deleted Adenoviral vector for treating a condition, disease or a disorder.04-02-2015

Xianghua Zhang, Aurora, CO US

Patent application numberDescriptionPublished
20100120155CONSTRUCTION OF FULLY-DELETED ADENOVIRUS-BASED GENE DELIVERY VECTORS AND USES THEREOF - The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector includes (a) providing an Adenovirus packaging cell line; (b) transfecting a fully-deleted Adenoviral vector construct into the cell line; and optionally (c) transfecting a packaging construct into the cell line, wherein the fully-deleted Adenoviral vector construct and optionally the packaging construct can transfect the Adenovirus packaging cell line resulting in the encapsidation of a fully-deleted Adenoviral vector independent of helper Adenovirus. In an embodiment, a target cell is transduced with the encapsidated fully-deleted Adenoviral vector for treating a condition, disease or a disorder.05-13-2010

Xiaoshi Zhang, Superior, CO US

Patent application numberDescriptionPublished
20120113513SELF-CLEANING OF OPTICAL SURFACES IN LOW-PRESSURE REACTIVE GAS ENVIRONMENTS IN ADVANCED OPTICAL SYSTEMS - Apparatus and methods for self-cleaning of optical elements in sealed environments over a wide range of operating optical frequencies prevent long-term power degradation by introducing low-pressure backfill of a reactive gas such as oxygen into a vacuum chamber containing the optical elements. The backfill pressure is preferably between 1005-10-2012

Ye Zhang, Broomfield, CO US

Patent application numberDescriptionPublished
20090048197Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).02-19-2009
20100063308LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).03-11-2010

Patent applications by Ye Zhang, Broomfield, CO US

Yongqiang Zhang, Longmont, CO US

Patent application numberDescriptionPublished
20120319044ORGANIC IONIC PHENYLPYRIMIDINE COMPOUNDS AND DISPLAYS FORMED THEREOF - Ionic mesogenic compounds of formula (I) can be used to form liquid crystal displays, such as ferroelectric liquid crystal displays, having enhanced anti-image sticking properties. The mesogenic compounds may contain a cationic group such as an ammonium or phosphonium group bonded to an alkyl chain that is terminally bonded to a para-substituted pyrimidyl benzene moiety. The counterion can be an organic or inorganic anion. The compounds can be used either as dopants in art ferroelectric liquid crystal compositions to reduce image sticking, or can be used as the primary or predominant component of a liquid crystal display system. Additional compounds, devices, and methods are disclosed.12-20-2012
20130172558NAPROXEN-BASED CHIRAL COMPOUNDS AND LIQUID CRYSTAL DISPLAY APPLICATIONS - Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compounds, which can be used in liquid crystal compositions useful for electro-optical and display device applications. The liquid crystal can be a ferroelectric liquid crystal. Also provided is a display device that includes the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound. Also provided is a method of preparing a liquid crystal display device on silicon that includes incorporating the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound, into a liquid crystal display on silicon by disposing the compound in a liquid crystal, or the liquid crystal, onto a silicon surface.07-04-2013
20160085148SULFONIC ACID DERIVATIVE COMPOUNDS AS PHOTOACID GENERATORS IN RESIST APPLICATIONS - Novel photoacid generator compounds are provided. Photoresist compositions that include the novel photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.03-24-2016

Patent applications by Yongqiang Zhang, Longmont, CO US

Yuetao Zhang, Fort Collins, CO US

Patent application numberDescriptionPublished
20140058041POLYMERIZATION CATALYSTS, METHODS AND PRODUCTS - The invention provides novel polymer compositions and methods for preparing such compositions. The invention also provides methods for polymerizing various unsaturated monomers, including naturally occurring or plant biomass-derived renewable acrylic monomers. The monomers can be rapidly polymerized using various organic catalysts or organometallic catalysts, as described herein. In one embodiment, nearly perfectly isotactic polymers (mmmm>99%) can be prepared using a C02-27-2014

Zhiyong Zhang, Aurora, CO US

Patent application numberDescriptionPublished
20110091482EXPRESSION OF KIR IN HUMAN CANCER CELLS AS A BIOMARKER FOR IMMUNO-ESCAPE AND CANCER METASTASIS - The present invention is based on the finding that the level of KIR expression in a cancer cell is significant with regard to tumor invasion and metastasis. Therefore, the present invention concerns methods and compositions for evaluating cancer in a patient based on KIR protein or mRNA expression. The invention also provides methods and compositions for treating cancer using a KIR inhibitor and methods of screening for KIR inhibitors.04-21-2011
Website © 2016 Advameg, Inc.