| Patent application number | Description | Published |
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| 20110093436 | Datacenter Workflow Automation Scenarios using Virtual Databases - Information from multiple databases is retrieved and stored on a database storage system. Multiple point-in-time copies are obtained for each database. A point-in-time copy retrieves data changed in the database since the retrieval of a previous point-in-time copy. A virtual database (VDB) is created by creating a set of files in the data storage system. Each file in the set of files created for a VDB is linked to the database blocks on the database storage system associated with a point-in-time copy of the source database. The set of files associated with the VDB are mounted on a database server allowing the database server to read from and write to the set of files. Workflows based on VDBs allow various usage scenarios based on databases to be implemented efficiently, for example, testing and development, backup and recovery, and data warehouse building. | 04-21-2011 |
| 20120084252 | Datacenter Workflow Automation Scenarios Using Virtual Databases - Information from multiple databases is retrieved and stored on a database storage system. Multiple point-in-time copies are obtained for each database. A point-in-time copy retrieves data changed in the database since the retrieval of a previous point-in-time copy. A virtual database (VDB) is created by creating a set of files in the data storage system. Each file in the set of files created for a VDB is linked to the database blocks on the database storage system associated with a point-in-time copy of the source database. The set of files associated with the VDB are mounted on a database server allowing the database server to read from and write to the set of files. Workflows based on VDBs allow various usage scenarios based on databases to be implemented efficiently, for example, testing and development, backup and recovery, and data warehouse building. | 04-05-2012 |
| 20120089570 | Virtual Database System - Information from multiple databases is retrieved and stored on a database storage system. Multiple point-in-time copies are obtained for each database. A point-in-time copy retrieves data changed in the database since the retrieval of a previous point-in-time copy. A virtual database (VDB) is created by creating a set of files in the data storage system. Each file in the set of files created for a VDB is linked to the database blocks on the database storage system associated with a point-in-time copy of the source database. The set of files associated with the VDB are mounted on a database server allowing the database server to read from and write to the set of files. Workflows based on VDBs allow various usage scenarios based on databases to be implemented efficiently, for example, testing and development, backup and recovery, and data warehouse building. | 04-12-2012 |
| 20150213036 | Datacenter Workflow Automation Scenarios Using Virtual Databases - Information from multiple databases is retrieved and stored on a database storage system. Multiple point-in-time copies are obtained for each database. A point-in-time copy retrieves data changed in the database since the retrieval of a previous point-in-time copy. A virtual database (VDB) is created by creating a set of files in the data storage system. Each file in the set of files created for a VDB is linked to the database blocks on the database storage system associated with a point-in-time copy of the source database. The set of files associated with the VDB are mounted on a database server allowing the database server to read from and write to the set of files. Workflows based on VDBs allow various usage scenarios based on databases to be implemented efficiently, for example, testing and development, backup and recovery, and data warehouse building. | 07-30-2015 |
| 20150248422 | Virtual Database System - Information from multiple databases is retrieved and stored on a database storage system. Multiple point-in-time copies are obtained for each database. A point-in-time copy retrieves data changed in the database since the retrieval of a previous point-in-time copy. A virtual database (VDB) is created by creating a set of files in the data storage system. Each file in the set of files created for a VDB is linked to the database blocks on the database storage system associated with a point-in-time copy of the source database. The set of files associated with the VDB are mounted on a database server allowing the database server to read from and write to the set of files. Workflows based on VDBs allow various usage scenarios based on databases to be implemented efficiently, for example, testing and development, backup and recovery, and data warehouse building. | 09-03-2015 |
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| 20100009866 | Surface Display of Whole Antibodies in Eukaryotes - Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest. | 01-14-2010 |
| 20100331192 | SURFACE DISPLAY OF RECOMBINANT PROTEINS IN LOWER EUKARYOTES - Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening libraries of recombinant proteins in lower eukaryotes to identify particular proteins with desired properties from the array of proteins in the libraries. The methods are particularly useful for constructing and screening antibody libraries in lower eukaryotes. | 12-30-2010 |
| 20110313137 | HER2 ANTIBODY COMPOSITIONS - The invention relates to compositions of Her2 antibody molecules with pre-selected N-linked glycosylation forms. | 12-22-2011 |
| 20120003695 | METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS - Lower eukaryotic cells such as | 01-05-2012 |
| 20120021948 | SURFACE DISPLAY OF WHOLE ANTIBODIES IN EUKARYOTES - Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest. | 01-26-2012 |
| 20130071390 | METHOD FOR PREPARING ANTIBODIES HAVING IMPROVED PROPERTIES - The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region. | 03-21-2013 |
| 20140086916 | METHOD FOR PREPARING Fc CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES - The present invention is directed to methods and compositions for the production of Fc-containing polypeptides comprising mutations at positions 243, 264, 267 and 328 of the Fc region. | 03-27-2014 |
| 20140186334 | SURFACE, ANCHORED FC-BAIT ANTIBODY DISPLAY SYSTEM - The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof. | 07-03-2014 |
| 20140286946 | METHOD FOR PREPARING ANTIBODIES HAVING IMPROVED PROPERTIES - The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties. | 09-25-2014 |
| 20140302028 | FC CONTAINING POLYPEPTIDES HAVING INCREASED ANTI-INFLAMMATORY PROPERTIES AND INCREASED FCRN BINDING - The present invention is directed to methods and compositions for the production of Fc-containing polypeptides which are useful as human or animal therapeutic agents, and which comprise increased anti-inflammatory properties and improved FcRn binding. | 10-09-2014 |
| 20140302556 | CONTROLLING O-GLYCOSYLATION IN LOWER EUKARYOTES - Lower eukaryote host cells in which expression of the endogenous protein mannosyltransferase 2 (PMT2) gene has been disrupted by introducing a nucleic acid molecule encoding a Pmt2p protein having a mutation in a conserved region of the protein. The mutation confers to the host cell resistance to PMT inhibitors, which are used to reduce the amount of O-glycosylation of recombinant proteins produced by the host cells but which also have the effect of reducing the robustness of the host cells during fermentation. When host cells that express the mutated PMT2 gene but not the endogenous Pmt2p are cultivated in the presence of a P MT inhibitor, the host cells display an increase in cellular robustness during fed-batch fermentation and express recombinant pro teins in high yield while the amounts O-glycosylation are similar to that produced under similar conditions by host cells that express only the endogenous P MT2 gene. | 10-09-2014 |
| 20150211000 | SURFACE DISPLAY OF RECOMBINANT PROTEINS IN LOWER EUKARYOTES - Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening libraries of recombinant proteins in lower eukaryotes to identify particular proteins with desired properties from the array of proteins in the libraries. The methods are particularly useful for constructing and screening antibody libraries in lower eukaryotes. | 07-30-2015 |
| 20160083765 | METHOD FOR PREPARING ANTIBODIES HAVING IMPROVED PROPERTIES - The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region. | 03-24-2016 |
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| 20120037751 | SUPERSONIC FLYING WING - A bidirectional flying wing maximizes efficiency and reduces sonic boom during supersonic flight. The flying wing has bilateral symmetry across two perpendicular planes and a substantially isentropic compression bottom surface that minimizes the shock wave projected downward during flight. The flying wing may be rotated to provide a high aspect ratio and a low sweep angle during subsonic flight. The flying wing may be rotated to provide a low aspect ratio and a high sweep angle during supersonic flight. | 02-16-2012 |
| 20130115069 | Vertical Axis Wind Turbine - A vertical axis wind turbine formed from a concentric arrangement of fixed stator blades to provide fluid flow acceleration into an arrangement of rotatable blades secured to a generator for invoking electrical power generation. The stator blades are maintained in a fixed position by use of an upper and lower stator plate. The rotor blades include an upper and lower plate, the upper plate coupled to the upper stator plate, and the lower rotor plate coupled to the generator. The amount of stator and rotor blades may be scaled in number and size depending upon the type of generator to be driven and associated mechanical energy to be obtained. The stator blades are designed for air deflection in a direction for optimal rotor blade rotation by accelerating air flow into a pre-swirl before the flow contacts the rotor blades. Each stator blade is oriented at a sufficient stagger angle so that an angle of the relative velocity does not exceed the stall angle of said rotor blade. | 05-09-2013 |
| 20140233123 | Low Drag Low Noise Devices Using Jet Flow Control - Low drag low noise devices are described herein that use passive jet flow control to reduce the drag and noise created by devices (e.g., motor vehicle side view mirrors) while the devices travel through fluid. The low drag low noise devices described herein comprise a lengthwise axis, an outer body, and an inner body. The outer body and the inner body cooperatively define a channel through which fluid can pass during use. | 08-21-2014 |
| 20150158439 | Low Drag Low Noise Devices Using Jet Flow Control - Low drag low noise devices are described herein that use passive jet flow control to reduce the drag and noise created by motor vehicles (e.g., motor vehicle side view mirrors) while the motor vehicles travel through a fluid. The low drag low noise devices described herein comprise a lengthwise axis, an outer body, and an inner body. The outer body and the inner body cooperatively define a channel through which fluid can pass during use. | 06-11-2015 |
| 20150233346 | VERTICAL AXIS WIND TURBINE - A vertical axis wind turbine formed from an arrangement of fixed stator blades to provide fluid flow acceleration into an arrangement of rotatable blades secured to a generator for invoking electrical power generation. The stator blades are maintained in position by use of a stator plate. Rotor blades are coupled to the generator. The amount of stator and rotor blades may be scaled in number and size depending upon the type of generator to be driven and associated mechanical energy to be obtained. The stator blades are designed for air deflection in a direction for optimal rotor blade rotation by accelerating air flow into a pre-swirl before the flow contacts the rotor blades. Each stator blade is oriented at a sufficient stagger angle so that an angle of the relative velocity does not exceed the stall angle of said rotor blade. | 08-20-2015 |
| 20160031496 | Low Drag Low Noise Devices Using Jet Flow Control - Low drag low noise devices are described herein that use passive jet flow control to reduce the drag and noise created by motor vehicles (e.g., motor vehicle side view mirrors and their main bodies) while the motor vehicles travel through a fluid. The low drag low noise devices described herein comprise a lengthwise axis, an outer body, and an inner body. The outer body and the inner body cooperatively define a channel through which fluid can pass during use. | 02-04-2016 |
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| 20130091258 | COMMUNICATION NETWORK TOPOLOGY MANAGEMENT BASED ON AN ASSOCIATED ELECTRIC GRID TOPOLOGY - In one embodiment, a computer determines a grid topology of an electric grid based on one or more electric grid configuration description files, and also determines a network topology of a computer network used to provide communication to grid devices of the electric grid. By assessing whether the network topology is configured to meet one or more communication requirements of the grid topology (e.g., initially and/or through monitoring for grid changes), the computer may trigger a corrective action (e.g., alarm or reconfiguration) in response to the network topology not being configured to meet the one or more communication requirements of the grid topology. | 04-11-2013 |
| 20150074260 | AUTO DISCOVERY AND TOPOLOGY RENDERING IN SUBSTATION NETWORKS - System, method, and computer program product to capture, at a first network element in a substation network, a first data packet transmitted according to a predefined protocol, compare a MAC address of the first data packet to a MAC address table of at least one of the plurality of network elements, upon determining that the MAC address of the first data packet is defined in the MAC address table as belonging to a first substation power device, identify, from the MAC address table, a first port of a first network element, that the first substation power device is connected to, and retrieve, from a Substation Configuration Language file, a name for the first substation power device based on a logical node name in the first data packet, and generate a visual depiction of a network topology of the plurality of network elements and the first substation power device. | 03-12-2015 |
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| 20100183937 | Fuel cell system having a hydrogen separation member - A fuel cell stack configured to input raw fuel from a fuel source to produce electrical energy includes a fuel cell comprising an anode, an electrolyte, and a cathode. The anode defines an anode chamber, and a hydrogen separation member is disposed within the anode chamber. The hydrogen separation member has a first side and a second side. The first side of the hydrogen separation member defines a raw fuel chamber. The hydrogen separation member transfer hydrogen between the first side and the second side to provide hydrogen fuel to the anode of the fuel cell, while inhibiting the transportation of gas molecules between the first side and the second side. | 07-22-2010 |
| 20100304253 | METHOD OF CONTROLLING A FUEL CELL SYSTEM UTILIZING A FUEL CELL SENSOR - A method for controlling a fuel cell system, the fuel cell system is described in accordance with exemplary embodiments. The method includes measuring an open circuit voltage of the fuel cell. The method further includes determining an air actuator control signal based on the open circuit voltage of the fuel cell. The method further includes controlling the air actuator based on the air actuator control signal. The method further includes determining a fuel actuator control signal based on the open circuit voltage of the fuel cell. The method further includes controlling the fuel actuator based on the fuel actuator control signal. | 12-02-2010 |
| 20100304254 | METHOD FOR CONTROLLING A FUEL CELL UTILIZING A FUEL CELL SENSOR - A method for controlling a fuel cell system including measuring an open circuit voltage of a fuel cell. The method further includes determining an air actuator control signal based on the open circuit voltage of the fuel cell. The method further includes controlling the air actuator based on the air actuator control signal. The method further includes determining a fuel actuator control signal based on the open circuit voltage of the fuel cell. The method further includes controlling the fuel actuator based on the fuel actuator control signal. | 12-02-2010 |
| 20120021314 | SOLID OXIDE FUEL CELL WITH INTERNAL REFORMING MEMBER - A solid oxide fuel cell module includes a fuel cell tube defining a fuel cell tube inner chamber. The fuel cell tube includes a fuel cell tube inlet, a fuel cell tube outlet, and an active portion comprising an anode layer, a cathode layer, and an electrolyte layer. The active portion is configured to react an oxidizing fluid and a reducing fluid to generate an electromotive force. The solid oxide fuel cell module further includes an internal reforming member disposed within the fuel cell tube, the internal reforming member being configured to receive raw fuel and convert raw fuel to reformed fuel. The solid fuel cell tube further includes an anode current collector disposed within the fuel cell tube, the anode current collector connected to the anode layer of the anode current collector and providing support to the internal reforming member such that the internal reforming member retains a desired position within the fuel cell tube. | 01-26-2012 |
| 20120077099 | SOLID OXIDE FUEL CELL WITH MULTIPLE FUEL STREAMS - Disclosed herein is a solid oxide fuel cell including an electrochemical cell, a first fuel reformer, and a first feed tube. The electrochemical cell includes an anode, a cathode, and an electrolyte. The anode at least partially defines an anode chamber. The anode is configured to convert a reformed fuel to an exhaust fluid comprising water. The fuel reformer is configured to receive raw fuel and to convert raw fuel to reformed fuel. The fuel reformer is disposed within the anode chamber. The first feed tube is disposed within the anode chamber. The first feed tube is configured to route raw fuel downstream the first fuel reformer such that raw fuel reacts with water of the exhaust fluid. | 03-29-2012 |
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| 20100031697 | MODULAR CO2 REFRIGERATION SYSTEM - A cascade CO2 refrigeration system includes a medium temperature loop for circulating a medium refrigerant and a low temperature loop for circulating a CO2 refrigerant. The medium temperature loop includes a heat exchanger having a first side and a second side. The first side evaporates the medium temperature refrigerant. The low temperature loop includes a discharge header for circulating the CO2 refrigerant through the second side of the heat exchanger to condense the CO2 refrigerant, a liquid-vapor separator collects liquid CO2 refrigerant and directs vapor CO2 refrigerant to the second side of the heat exchanger. A liquid CO2 supply header receives liquid CO2 refrigerant from the liquid-vapor separator. Medium temperature loads receive liquid CO2 refrigerant from the liquid supply header for use as a liquid coolant at a medium temperature. An expansion device expands liquid CO2 refrigerant from the liquid supply header into a low temperature liquid-vapor mixture for use by the low temperature loads. | 02-11-2010 |
| 20120117996 | CASCADE REFRIGERATION SYSTEM WITH MODULAR AMMONIA CHILLER UNITS - A cascade refrigeration system includes an upper portion having at least one modular chiller unit that provides cooling to at least one of a low temperature subsystem having a plurality of low temperature loads, and a medium temperature subsystem having a plurality of medium temperature loads. The modular chiller unit includes a refrigerant circuit having at least a compressor, a condenser, an expansion device, and an evaporator. An ammonia refrigerant mixed with a soluble oil circulates within the refrigerant circuit. A control device may be programmed to modulate the position of the expansion device so that a superheat temperature of the ammonia refrigerant near an outlet of the evaporator fluctuates within a substantially predetermined superheat temperature range to positively return soluble oil from the evaporator to the compressor. | 05-17-2012 |
| 20130091891 | CASCADE REFRIGERATION SYSTEM WITH MODULAR AMMONIA CHILLER UNITS - A cascade refrigeration system including an upper portion having at least one modular chiller unit that provides cooling to at least one of a low temperature subsystem having a plurality of low temperature loads, and a medium temperature subsystem having a plurality of medium temperature loads. The modular chiller unit includes a refrigerant circuit having at least a compressor, a condenser, an expansion device, and an evaporator. An ammonia refrigerant which may have entrained oil from the compressor circulates within the refrigerant circuit. An oil recycling circuit removes some oil from the ammonia refrigerant for return to the compressor. An oil pot collects oil accumulated in the evaporator and an oil return line drains oil from the oil pot to an ammonia accumulator or directly to the compressor. | 04-18-2013 |
| 20140102132 | MODULAR CO2 REFRIGERATION SYSTEM - A cascade CO2 refrigeration system includes a medium temperature loop for circulating a medium refrigerant and a low temperature loop for circulating a CO2 refrigerant. The medium temperature loop includes a heat exchanger having a first side and a second side. The first side evaporates the medium temperature refrigerant. The low temperature loop includes a discharge header for circulating the CO2 refrigerant through the second side of the heat exchanger to condense the CO2 refrigerant, a liquid-vapor separator collects liquid CO2 refrigerant and directs vapor CO2 refrigerant to the second side of the heat exchanger. A liquid CO2 supply header receives liquid CO2 refrigerant from the liquid-vapor separator. Medium temperature loads receive liquid CO2 refrigerant from the liquid supply header for use as a liquid coolant at a medium temperature. An expansion device expands liquid CO2 refrigerant from the liquid supply header into a low temperature liquid-vapor mixture for use by the low temperature loads. | 04-17-2014 |
| 20150345835 | REFRIGERATION SYSTEM WITH ABSORPTION COOLING - A refrigeration system for use with refrigerated LT and MT display cases in facilities such as supermarkets, has an absorption chiller that uses waste heat from a nearby source to provide cooling to the refrigeration system to take advantage of the synergy and improve overall efficiency of the refrigeration system. The cooling provided by the absorption chiller may be in the form of a coolant (e.g. water, glycol, water-glycol mixture, etc.) that circulates between the chiller and one or more of a pre-cooler, sub-cooler or condenser in the refrigeration system in a manner that uses waste heat from a nearby source to reduce the need for installed condensing capacity in the refrigeration system and improve thermal efficiency and obtain cost savings. | 12-03-2015 |
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| 20110053242 | Immunoaffinity isolation of modified peptides from complex mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 03-03-2011 |
| 20120244594 | Immunoaffinity isolation of modified peptides from complex mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 09-27-2012 |
| 20140094594 | Immunoaffinity Isolation of Modified Peptides From Complex Mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 04-03-2014 |
