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| 20110046429 | Method for preparing linear alpha-olefins - The present invention relates to a method for preparing linear alpha-olefins (LAO) by oligomerization of ethylene in the presence of solvent and homogenous catalyst, comprising the steps of: (i) feeding ethylene, solvent and catalyst into an oligomerization reactor, (ii) oligomerizing the ethylene in the reactor, (iii) removing a reactor outlet stream comprising solvent, linear alpha-olefins, ethylene, and catalyst from the reactor via a reactor outlet piping system, (iv) transferring the reactor outlet stream to a catalyst deactivation and removal step, and (v) deactivating and removing the catalyst from the reactor outlet stream, characterized in that at least one organic amine is added into the oligomerization reactor and/or into the reactor outlet piping system. | 02-24-2011 |
| 20110054233 | METHOD FOR OLIGOMERIZATION OF ETHYLENE AND REACTOR SYSTEM THEREFOR - The present invention relates to a method and a reactor system, for the oligomerization of ethylene, comprising oligomerizing ethylene in a reactor in the presence of a solvent and a catalyst composition to produce a liquid product stream comprising linear alpha-olefins, solvent and catalyst composition, and deactivating and extracting the catalyst composition in said liquid product stream by mixing it with a polar phase in a dynamic mixing device having rotor and stator elements comprising concentric tool rings. | 03-03-2011 |
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| 20110046429 | Method for preparing linear alpha-olefins - The present invention relates to a method for preparing linear alpha-olefins (LAO) by oligomerization of ethylene in the presence of solvent and homogenous catalyst, comprising the steps of: (i) feeding ethylene, solvent and catalyst into an oligomerization reactor, (ii) oligomerizing the ethylene in the reactor, (iii) removing a reactor outlet stream comprising solvent, linear alpha-olefins, ethylene, and catalyst from the reactor via a reactor outlet piping system, (iv) transferring the reactor outlet stream to a catalyst deactivation and removal step, and (v) deactivating and removing the catalyst from the reactor outlet stream, characterized in that at least one organic amine is added into the oligomerization reactor and/or into the reactor outlet piping system. | 02-24-2011 |
| 20110054233 | METHOD FOR OLIGOMERIZATION OF ETHYLENE AND REACTOR SYSTEM THEREFOR - The present invention relates to a method and a reactor system, for the oligomerization of ethylene, comprising oligomerizing ethylene in a reactor in the presence of a solvent and a catalyst composition to produce a liquid product stream comprising linear alpha-olefins, solvent and catalyst composition, and deactivating and extracting the catalyst composition in said liquid product stream by mixing it with a polar phase in a dynamic mixing device having rotor and stator elements comprising concentric tool rings. | 03-03-2011 |
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| 20120277373 | MOISTURE-CURING FORMULATIONS WITH TIME-MODIFIED PHASES - The invention aims to allow a curable composition to have an extended working phase followed by a short time period in which said compound becomes fully cured. This is achieved by the provision of a curable composition comprising the following components: a) at least one polyether and/or at least one polyacrylic acid ester with at least one reactive silyl group as an end-group; b) at least one organotin compound; and c) at least one compound that does not contain any tin or silicon atoms and that has at least two functional groups. Said groups are selected from the following: carboxy, carbonyl or hydroxy groups, or nitrogen atoms that are part of a ring system with aromatic character. In addition, the invention relates to a method for producing such a composition, and to the use thereof as an adhesive, a sealant or as a coating material. | 11-01-2012 |
| 20130085239 | POLYETHER BLOCK COPOLYMERS AND COMPOSITIONS THAT CAN BE OBTAINED THEREFROM - Polyether block copolymers of the general structure B-(A-OH) | 04-04-2013 |
| 20130172511 | BLOCK COPOLYMERS ON THE BASIS OF (METH)ACRYLATE - The invention relates to block copolymers produced by means of controlled polymerization and that have at least one block A or B comprising (meth)acrylate monomers and copolymerizable monomers, and a block P on the basis of functionalized polymers. | 07-04-2013 |
| 20130274414 | CURABLE COMPOSITION HAVING A SPECIAL CATALYST/SOFTNER SYSTEM - In a curable composition that contains at least one polymer having at least one terminal group of the general formula (I)-A | 10-17-2013 |
| 20130280530 | TWO-COMPONENT CURABLE COMPOSITION - In the context of a curable agent based on at least one silyl-terminated polymer, the adhesion spectrum for bonding plastics, and the speed at which adhesion builds up, are to be improved. This is achieved by making available a curable agent containing two components (1) and (2) that are not in mutual contact, where component (1) contains at least one polymer having at least one terminal group of formula (I) -A | 10-24-2013 |
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| 20120255467 | DEVICE FOR MANAGING VALUABLES INCLUDING MONEY - The invention refers to a device for management, collection, and/or dispensing of valuables, in particular money, with a locked vault area and an operator and service area, wherein all of the valuables as well as the vault area's controlling units are essentially arranged completely within the vault area, preferably in a certified vault, and essentially all control electronics is arranged in the operator and service area, whereby the vault area and the operator and service area exhibit separate locking systems. According the invention, a second vault area is provided in which the control electronics for controlling the controlling units in the first vault area is arranged wherein said second vault area is separated both from the first vault area for collecting the valuables and from the remaining operator and service area, and exhibits a locking system separate from that of the first vault area and of the operator and service area. | 10-11-2012 |
| 20120255468 | CASH MACHINE FOR THE MANAGEMENT, INSERTION OR WITHDRAWAL OF VALUABLES - A cash machine having a device housing with a first door for accessing valuables and a printer housing affixed within the device housing. The printer housing isolates the printer from the device housing. The printer housing has a second door. A printer and a paper roll mount on the second door either directly or with a holding fixture. The second door moves from a closed configuration where the door is closed to an open configuration where the door is open to enable access to the printer and the paper roll. When the second door is in the open configuration at least a portion of the printer and the printer roll extend out from the device housing to facilitate maintenance. | 10-11-2012 |
| 20140216889 | DEVICE FOR THE ACCEPTANCE OF COINS - A device for the acceptance of coins which allows the acceptance of individual coins as well as the acceptance of various coins for further processing of the coins, whereby the device includes a laterally moveable holding fixture. The holding fixture has both a side with a coin insertion slot, and a receptacle area for the reception of a plurality of coins. | 08-07-2014 |
| 20140238280 | CASH MACHINE FOR THE MANAGEMENT, INSERTION OR WITHDRAWAL OF VALUABLES - A cash machine having a device housing with a first door for accessing valuables and a printer housing affixed within the device housing. The printer housing isolates the printer from the device housing. The printer housing has a second door. A printer and a paper roll mount on the second door either directly or with a holding fixture. The second door moves from a closed configuration where the door is closed to an open configuration where the door is open to enable access to the printer and the paper roll. When the second door is in the open configuration at least a portion of the printer and the printer roll extend out from the device housing to facilitate maintenance. | 08-28-2014 |
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| 20130072931 | METHOD FOR TIBIAL NAIL INSERTION - A method for implanting a longitudinal intramedullary nail into the tibia comprises inserting the tibia nail along a plane of symmetry through the tuberositas tibiae. Thereby, the tuberositas tibiae can be used during nail insertion to correctly align the nail and the target arm to the symmetry plane of the bone. This means, that the whole construct, the nail attached to the target arm, has to be inserted in external rotation. | 03-21-2013 |
| 20140214094 | ANGULARLY STABLE FIXATION OF AN IMPLANT - A system and method of angularly stable fixation of an implant on a bone includes the steps of making at least one hole in the bone by means of a bone drill. An implant is placed on the bone in a desired position and joining the implant with the bone, such that the implant is prevented from rotation about its attachment point. A system is provided for use in the above described method. The system comprises a bone drill, an implant and a sonotrode for angularly stable fixation of the implant on the bone. The system can further comprise a joining element to join the implant with the bone. | 07-31-2014 |
| 20150073415 | METHOD FOR TIBIAL NAIL INSERTION - A method for implanting a longitudinal intramedullary nail into the tibia comprises inserting the tibia nail along a plane of symmetry through the tuberositas tibiae. Thereby, the tuberositas tibiae can be used during nail insertion to correctly align the nail and the target arm to the symmetry plane of the bone. This means, that the whole construct, the nail attached to the target arm, has to be inserted in external rotation. | 03-12-2015 |
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| 20080233012 | Method for preventing repeat use of disposable articles in analyzers - The invention concerns the field of automatic analysis instruments (analyzers) and relates to a method for preventing repeat use of disposable articles in analyzers. | 09-25-2008 |
| 20090011520 | Stable D-dimer liquid preparation - The invention is in the field of coagulation diagnosis and relates to a liquid, buffer-based D-dimer composition, which additionally contains fibrinogen and which is suitable as a standard material for control or calibration purposes for D-dimer test procedures. | 01-08-2009 |
| 20100086953 | Blood Coagulation Assays - The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety. | 04-08-2010 |
| 20120156708 | Method For Simultaneously Determining Multiple Coagulation Proteases - The present invention relates to a chromogenic method for simultaneously determining the activity of multiple coagulation proteases or for simultaneously determining the inhibition of multiple coagulation proteases in a single test reaction. For this purpose, use is made of two chromogenic substrates which have different absorption maxima and whose color signals can be separated spectrally. | 06-21-2012 |
| 20120190053 | Method of determining factor XIII with the aid of plasma-based reference material - The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method. | 07-26-2012 |
| 20120202232 | Heparin-insensitive Method for Determining Direct Coagulation Factor Inhibitors - The invention is in the field of coagulation diagnostics and relates to a heparin-insensitive method for determining direct coagulation factor inhibitors in a sample, in particular direct thrombin and factor Xa inhibitors. | 08-09-2012 |
| 20120237960 | Devices and Methods for Determining the Platelet Function in a Centrifugal Analyzer - The invention lies in the field of platelet function diagnostics and relates to devices and methods for determining the platelet function in a centrifugal analyzer. | 09-20-2012 |
| 20120252044 | Controls and kit for thrombocyte activity tests - The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function. | 10-04-2012 |
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| 20130178437 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch (HAS) conjugates and to a method for preparing the hydroxyalkyl starch (HAS) conjugates, the hydroxyalkyl starch (HAS) conjugates comprising a hydroxyalkyl starch derivative and a cytotoxic agent, said conjugate having a structure according the following formula HAS′(-M) | 07-11-2013 |
| 20130184454 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) | 07-18-2013 |
| 20130184455 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 07-18-2013 |
| 20130211060 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 08-15-2013 |
| 20130217871 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch conjugates and a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one primary hydroxyl group, wherein the hydroxyalkyl starch is linked via said primary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) | 08-22-2013 |
| 20140073778 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) | 03-13-2014 |
| 20140073779 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 03-13-2014 |
| 20140088298 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 03-27-2014 |
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| 20100314376 | ROBOT HOLDER FOR FLUID-COOLED JOINING TOOLS - The invention relates to a robot holder for fixing a fluid-cooled joining tool ( | 12-16-2010 |
| 20130298943 | CLEANING STATION FOR CLEANING WELDING TORCHES - A cleaning station and method for cleaning welding torches disposed on welding robots, in particular a cleaning station and method for cleaning the interior of gas nozzles on electrical arc welding torches, which has a simpler and more robust construction, while at the same time having a reliable cleaning effect. The cleaning station has a cleaning wire, one end of which is attached on one side to a base and extends from the base towards a free end, wound in a coil around a longitudinal axis, wherein the outer diameter of the coil formed by the cleaning wire is dimensioned in such a way that the coil at the free end of the cleaning wire is inserable, at least along a section of its length, into a welding torch, especially into a gas nozzle of an electrical arc welding torch. | 11-14-2013 |
| 20130313241 | GAS-COOLED WELDING GUN FOR AN ARC WELDING DEVICE - A gas-cooled welding gun for an arc welding device, comprising an electrically conductive current contact tube disposed concentrically within an electrically conductive outer tube and separated therefrom by an intermediate space. The current contact tube includes a wire guiding channel for a welding wire. A plurality of spacers is disposed at intervals in the intermediate space between the current contact tube and outer tube,. electrically insulating these components from each other. A shielding gas is provided in the intermediate space to cool the system and openings in the spacers allow the gas to flow therethrough. Structures are provided on the current contact tube which increase the overall surface area thereof. Regions of the surface of the current contact tube not covered by spacers are exposed toward the intermediate space and therefore to the shielding gas. | 11-28-2013 |
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| 20110112390 | APPARATUS AND METHOD FOR BLOOD CLOTTING DIAGNOSTICS - In order to be able still more precisely to determine the blood clotting activity in a patient according to the invention there is provided a method of extracorporeal determination of the blood clotting activity of a blood sample of an individual, in which the clotting time which elapses until the blood sample reaches a given degree of clotting or the degree of clotting reached by the blood sample within a given time is measured or in which in a corresponding manner the fibrinolysis time or the degree of fibrinolysis of a blood sample which has previously clotted to a certain degree is measured, the method being characterised in that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air. In addition according to the invention there is proposed a corresponding apparatus for the extracorporeal determination of the blood clotting activity wherein the apparatus has a measurement chamber for measuring the clotting time, the degree of clotting, the fibrinolysis time or the degree of fibrinolysis of a blood sample, the apparatus being characterised in that the measurement chamber is of such a configuration that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air. | 05-12-2011 |
| 20140323573 | METABOLIZABLE SALTS AND USE THEREOF IN DIAGNOSTICS AND THERAPY - The present invention proposes novel salt compounds for use in the diagnosis or therapy of a patient as well as drugs, medical products, diagnostic compositions or blood products containing a salt compound according to the invention. The salt compounds according to the invention comprise the cation of a metabolisable basic amino acid and the anion of a metabolisable carboxylic acid or an anion of carbonic acid. Those salt compounds therefore have the advantage that they are fully metabolisable and thus do not adversely affect the electrolyte balance or the acid-base balance of the patient. The proposed salt compounds are particularly suitable for the therapy of the liquid and electrolyte balance of a patient but also for adjusting the pH-value in a biological or medical sample, for adjusting the osmolality in infusion solutions, as buffer substances, for feeding biocarbonate to a patient and for inhibiting blood coagulation for example in a patient, in extracorporeal blood treatment in the diagnostic determination of blood coagulation or in the production, storage and preparation of blood products. | 10-30-2014 |
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| 20110183864 | METHOD FOR LUNG CANCER EARLY DETECTION AND PROGNOSIS - The present invention provides method for the prognosis or detection of lung cancer, notably for early detection of lung cancer, as well as a kit and a (micro) array suitable for said method. | 07-28-2011 |
| 20110319415 | Susceptibility to HSP90-Inhibitors - The present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to an HSP90 inhibitor. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell to treatment with an HSP90 inhibitor is described herein. In particular, the present invention provides for an in vitro method for the identification of a responder for or a patient sensitive to an HSP90 inhibitor and uses of an oligo- or polynucleotide capable of detecting (an) activating mutation(s) in the KRAS gene are provided. The present invention also relates to a method of monitoring the efficacy of a treatment of a cancer characterized by the presence of at least one activating mutation in the KRAS gene, and. optionally, in the EGFR gene and/or the BRAF gene. In addition, a method of predicting the efficacy of a cancer treatment is described, in particular in a cancer that is characterized by the presence of at least one activating mutation in the KRAS gene. and. optionally, in the EGFR gene and/or the BRAF gene. Also the use of a (transgenic) non-human animal or a (transgenic) cell having at least one activating mutation in the KRAS gene, and, optionally, in the EGFR gene and/or the BRAF gene for screening and/or validation of a medicament for the treatment of said cancer is described and a kit useful for carrying out the methods described herein is provided. | 12-29-2011 |
| 20130023420 | SUSCEPTIBILITY TO HSP90-INHIBITORS - The present invention relates to a combination of cell lines as well as a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to an HSP90 inhibitor anti-tumor agent. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell or collection of cells or cell lines to treatment with a drug such as an HSP90 inhibitor anti-tumor agent is described herein. | 01-24-2013 |
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| 20080213085 | Steam Turbine and Method for Operation of a Steam Turbine - Disclosed is a steam turbine comprising an exterior housing and an interior housing. The exterior housing and the interior housing are provided with a fresh steam supply duct. A rotor that encompasses several impeller blades and a thrust-compensating piston is rotably mounted within the interior housing. Said interior housing is equipped with several guide blades that are disposed such that a flow duct comprising several blade stages, each of which comprises a series of impeller blades and a series of guide blades, is formed along a specific direction of flow. The interior housing is further equipped with a recirculation duct which is embodied as a pipe that communicates between a space located between the interior housing and the exterior housing and the flow duct downstream of a blade stage. The interior housing is additionally equipped with a supply duct that is configured as a pipe which communicates between the space located between the interior housing and the exterior housing and an antechamber of the thrust-compensating piston located between the thrust-compensating piston of the rotor and of the interior housing. | 09-04-2008 |
| 20120257959 | STEAM TURBINE IN A THREE-SHELLED DESIGN - A turbomachine including a rotor and an inner interior housing an outer interior housing and an exterior housing, wherein the turbomachine has a first flow and a second flow arranged opposite the first flow for a high-pressure blading or medium-pressure blading, wherein the inner interior housing is made of a higher quality material tan the outer interior housing and solely accommodates the high-pressure and medium-pressure inflow regions including the balance piston is provided. | 10-11-2012 |
| 20130119116 | METHOD FOR WELDING HALF SHELLS - A method for welding half shells and thus a method for producing large volume components, such as an inner housing for a steam turbine is disclosed. Two half shells are connected to each other forming a tube-like cross section, and are welded by means of a girth weld to two further half shells that are connected to each other. | 05-16-2013 |
| 20130170956 | DISABLING CIRCUIT IN STEAM TURBINES FOR SHUTTING OFF SATURATED STEAM - A cooling option for a steam turbine is provided, wherein the steam turbine includes a high-pressure zone and a medium-pressure zone, wherein the saturated steam streaming out of the high-pressure zone is discharged via a saturated steam conduit to a first pressure chamber in a second flow channel of the medium-pressure zone and thus the possibility of the saturated steam causing damage by corrosion and erosion in the high-pressure zone is prevented. | 07-04-2013 |
| 20140199161 | STEAM TURBINE COMPRISING A THRUST BALANCE PISTON - A cooling mechanism for a steam turbine is provided, which has, in the area of the valve connection a cooling channel, into which cooling steam flows from the flow channel, the steam then being fed as cooling steam in the area of the thrust balance piston. | 07-17-2014 |
