Patent application number | Description | Published |
20100052155 | METHODS OF PROMOTING ADHESION BETWEEN TRANSFER MOLDED IC PACKAGES AND INJECTION MOLDED PLASTICS FOR CREATING OVER-MOLDED MEMORY CARDS - A flash memory card and methods of manufacturing same are disclosed. The card includes a semiconductor package fabricated to receive a single-sided or double-sided lid. A surface of the semiconductor package may be formed with holes, trenches and/or pockmarks. After the holes, trenches and/or pockmarks are formed, a lid may be attached to the package surface in an injection molding process. During the injection molding process, the molten plastic flows into the holes, trenches and/or pockmarks to interconnect with the surface of the semiconductor package. Thus, when the molten plastic hardens, the holes, trenches and/or pockmarks ensure that the lid remains firmly attached to semiconductor package. | 03-04-2010 |
20100055836 | METHOD OF STACKING AND INTERCONNECTING SEMICONDUCTOR PACKAGES VIA ELECTRICAL CONNECTORS EXTENDING BETWEEN ADJOINING SEMICONDUCTOR PACKAGES - An electronic component is disclosed including a plurality of stacked semiconductor packages. A first such embodiment includes an internal connector for electrically coupling the stacked semiconductor packages. A second such embodiment includes an external connector for electrically coupling the stacked semiconductor packages. | 03-04-2010 |
20100055847 | METHODS OF PROMOTING ADHESION BETWEEN TRANSFER MOLDED IC PACKAGES AND INJECTION MOLDED PLASTICS FOR CREATING OVER-MOLDED MEMORY CARDS - A flash memory card and methods of manufacturing same are disclosed. The card includes a semiconductor package fabricated to receive a single-sided or double-sided lid. A surface of the semiconductor package may be formed with holes, trenches and/or pockmarks. After the holes, trenches and/or pockmarks are formed, a lid may be attached to the package surface in an injection molding process. During the injection molding process, the molten plastic flows into the holes, trenches and/or pockmarks to interconnect with the surface of the semiconductor package. Thus, when the molten plastic hardens, the holes, trenches and/or pockmarks ensure that the lid remains firmly attached to semiconductor package. | 03-04-2010 |
20100252315 | Printed Circuit Board With Coextensive Electrical Connectors And Contact Pad Areas - A printed circuit board is disclosed having coextensive electrical connectors and contact pad areas. Areas of the contact pads where the traces and/or vias are located may be etched away to ensure electrical isolation between the traces, vias and contact pads. | 10-07-2010 |
20110316164 | CORRUGATED DIE EDGE FOR STACKED DIE SEMICONDUCTOR PACKAGE - A semiconductor die and semiconductor package formed therefrom, and methods of fabricating the semiconductor die and package, are disclosed. The semiconductor die includes an edge formed with a plurality of corrugations defined by protrusions between recesses. Bond pads may be formed on the protrusions. The semiconductor die formed in this manner may be stacked in the semiconductor package in staggered pairs so that the die bond pads on the protrusions of a lower die are positioned in the recesses of the upper die. | 12-29-2011 |
20120025396 | SEMICONDUCTOR DEVICE WITH DIE STACK ARRANGEMENT INCLUDING STAGGERED DIE AND EFFICIENT WIRE BONDING - A semiconductor die package is disclosed. An example of the semiconductor package includes a first group of semiconductor die interspersed with a second group of semiconductor die. The die from the first and second groups are offset from each other along a first axis and staggered with respect to each other along a second axis orthogonal to the first axis. A second example of the semiconductor package includes an irregular shaped edge and a wire bond to the substrate from a semiconductor die above the lowermost semiconductor die in the package. | 02-02-2012 |
20120164828 | HIDDEN PLATING TRACES - A strengthened semiconductor die substrate and package are disclosed. The substrate may include contact fingers formed with nonlinear edges. Providing a nonlinear contour to the contact finger edges reduces the mechanical stress exerted on the semiconductor die which would otherwise occur with straight edges to the contact fingers. The substrate may additionally or alternatively include plating traces extending at an angle from the contact fingers. Extending at an angle, at least the ends of the plating traces at the edge of the substrate are covered beneath a lid in which the semiconductor package is encased. Thus, when in use with a host device, contact between the ends of the plating traces beneath the lid and contact pins of the host device is avoided. | 06-28-2012 |
20130207280 | SEMICONDUCTOR DEVICE WITH DIE STACK ARRANGEMENT INCLUDING STAGGERED DIE AND EFFICIENT WIRE BONDING - A semiconductor die package is disclosed. An example of the semiconductor package includes a first group of semiconductor die interspersed with a second group of semiconductor die. The die from the first and second groups are offset from each other along a first axis and staggered with respect to each other along a second axis orthogonal to the first axis. A second example of the semiconductor package includes an irregular shaped edge and a wire bond to the substrate from a semiconductor die above the lowermost semiconductor die in the package. | 08-15-2013 |
20130299959 | RIGID WAVE PATTERN DESIGN ON CHIP CARRIER SUBSTRATE AND PRINTED CIRCUIT BOARD FOR SEMICONDUCTOR AND ELECTRONIC SUB-SYSTEM PACKAGING - A rigid wave pattern formed on a first side of a substrate in a semiconductor die package. The rigid wave pattern aligns with and overlies the contact fingers formed on the second side of the substrate. The rigid wave pattern includes a first pattern with an etched portion and an unetched portion around the etched portion. When the substrate and dice are encased during the molding process, the rigid wave pattern effectively reduces deformation of and stresses on the dice, therefore substantially alleviating die cracking. | 11-14-2013 |
20150054177 | RIGID WAVE PATTERN DESIGN ON CHIP CARRIER SUBSTRATE AND PRINTED CIRCUIT BOARD FOR SEMICONDUCTOR AND ELECTRONIC SUB-SYSTEM PACKAGING - A rigid wave pattern formed on a first side of a substrate in a semiconductor die package. The rigid wave pattern aligns with and overlies the contact fingers formed on the second side of the substrate. The rigid wave pattern includes a first pattern with an etched portion and an unetched portion around the etched portion. When the substrate and dice are encased during the molding process, the rigid wave pattern effectively reduces deformation of and stresses on the dice, therefore substantially alleviating die cracking. | 02-26-2015 |
Patent application number | Description | Published |
20080233610 | SOMATIC CELL REPROGRAMMING - The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method. | 09-25-2008 |
20100184227 | PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPROGRAMMING - Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed. | 07-22-2010 |
20110028537 | SOMATIC CELL REPROGRAMMING - The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method. | 02-03-2011 |
20110104125 | EPISOMAL REPROGRAMMING WITH CHEMICALS - Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided. | 05-05-2011 |
20130210138 | SOMATIC CELL REPROGRAMMING - The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method. | 08-15-2013 |
20130217117 | PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPROGRAMMING - Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed. | 08-22-2013 |
Patent application number | Description | Published |
20090081784 | GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS - Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed. | 03-26-2009 |
20100015705 | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions - Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed. | 01-21-2010 |
20110280844 | HEPATOCYTE PRODUCTION BY FORWARD PROGRAMMING - The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects. | 11-17-2011 |
20120009618 | ENDOTHELIAL CELL PRODUCTION BY PROGRAMMING - The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects. | 01-12-2012 |
20130251694 | HEPATOCYTE PRODUCTION BY FORWARD PROGRAMMING - The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects. | 09-26-2013 |
20140037600 | HEMATOPOIETIC PRECURSOR CELL PRODUCTION BY PROGRAMMING - The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects. | 02-06-2014 |
20140057355 | SOMATIC CELL REPROGRAMMING - The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method. | 02-27-2014 |
20140242595 | HEPATOCYTE PRODUCTION VIA FORWARD PROGRAMMING BY COMBINED GENETIC AND CHEMICAL ENGINEERING - The present invention provides methods comprising both genetic and chemical means for the production of hepatocytes from a variety of cell sources, particularly pluripotent stem cells. | 08-28-2014 |
20140349398 | ENDOTHELIAL CELL PRODUCTION BY PROGRAMMING - The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects. | 11-27-2014 |
Patent application number | Description | Published |
20080213365 | UNUSUALLY STABLE GLASSES AND METHODS FOR FORMING SAME - The present invention provides vapor deposition-methods that overcome the kinetic restrictions imposed by more conventional vapor deposition processes and liquid-cooling techniques to form amorphous molecular solids with greatly enhanced-stabilities. The present methods produce amorphous molecular solids having stabilities, as measured by fictive temperature, that cannot be achieved using liquid-cooling methods. | 09-04-2008 |
20080233157 | INHIBITING SURFACE ENHANCED CRYSTALLIZATION OF AMORPHOUS PHARMACEUTICALS WITH ULTRATHIN COATINGS - The present invention provides surface-stabilized amorphous pharmaceuticals comprising an amorphous pharmaceutical substrate coated with a biocompatible immobilizing material. Amorphous pharmaceutical substrates that are prone to surface enhanced crystallization benefit from the present coatings. The coated amorphous pharmaceuticals of the present invention maintain their amorphous state and, therefore, their solubility over extended periods of time, relative to uncoated pharmaceuticals. | 09-25-2008 |
20110261857 | METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER - A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices. The method relies on the detection of the dissolution endpoint of a drug/polymer mixture prepared by cryomilling. | 10-27-2011 |
20130199313 | METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER - A method for evaluating the solubility of a crystalline substance in a polymer comprises a) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration; b) annealing the sample at a constant temperature T | 08-08-2013 |
Patent application number | Description | Published |
20080319099 | Multifunctional silicone blends - Generally silicone materials adapted to releasably adhere to human skin don't attach readily to substrates such as fibrous substrates (e.g., woven and nonwoven webs), films, plastic, etc. Disclosed are inventive blends of low-tack materials, such as a low-tack silicone material, and a high-tack silicone material, such as a high-tack, hot-melt, silicone adhesive, that both releasably adhere to skin and join to various substrates, including fibrous substrates. Furthermore, these same blends may be disposed between, and attached to, a silicone adhesive layer and a substrate. In other words, the disclosed silicone blends may be used to join a silicone adhesive layer to a substrate. | 12-25-2008 |
20090069771 | BODY ADHERING ABSORBENT ARTICLE AND METHOD OF ADHERING SUCH ARTICLE TO A WEARER - In a body adhering absorbent article, an absorbent structure is configured for disposition adjacent a female wearer's vaginal region to absorb bodily fluids discharged by the wearer. A shell supports the absorbent structure at the vaginal region and has an adhesive on a body-facing surface thereof for adhering the shell directly to the wearer. A placement aid is disposed on at least one of the absorbent structure and the shell, and is configured for sensory perception by a wearer of the article upon placement of the article on the wearer to facilitate positive alignment of the absorbent article in a target placement region of the wearer with the absorbent structure disposed adjacent the wearer's vaginal region. | 03-12-2009 |
20100121304 | Multifunctional Acrylate Skin-Adhesive Composition - Improved skin-adhesive compositions for bonding a substrate, such as an absorbent article, to skin are disclosed. More particularly, the skin-adhesive composition has an improved, yet gentle, adhesion to the skin of a user, while maintaining strong, effective bonding to various inanimate, non-skin substrates. In one embodiment, the skin-adhesive composition can provide one or more skin benefit agents to the user. The skin-adhesive composition may applied to an absorbent article, such as a panty-liner, sanitary napkin, or an incontinence article, for directly adhering the article to the skin of a user. | 05-13-2010 |
20100152689 | Physical sensation absorbent article - An absorbent article is provided including a liquid impermeable outercover, an absorbent body disposed on the outercover, and a body-facing inner surface including body adhesive disposed thereon. The absorbent article also includes a physical sensation member disposed between the absorbent body and the wearer, the physical sensation member adapted to provide a physical sensation to the wearer when the physical sensation member is contacted by a bodily exudate. The absorbent article is also provided including a liquid impermeable outercover, an absorbent body disposed on the outercover, and a physical sensation member disposed on the absorbent body, the physical sensation member adapted to provide a physical sensation to the wearer. The absorbent article also provides a liquid permeable, wherein the liner includes a body-facing inner surface including body adhesive disposed thereon. | 06-17-2010 |
20110315309 | METHOD OF FORMING A NONWOVEN FABRIC AND FASTENING SYSTEM THAT INCLUDE AN AUTO-ADHESIVE MATERIAL - In some embodiments, a nonwoven fabric includes a first web that is at least partially formed of extruded strands which include an auto-adhesive material. The nonwoven fabric is adapted to be bonded to another item that includes a similar auto-adhesive material. In other embodiments, a method of forming a nonwoven fabric includes extruding a plurality of strands that are formed of an auto-adhesive material. The method further includes routing the plurality of strands toward a moving support, depositing the plurality of strands onto the moving support, and then stabilizing the plurality of strands to form a web. In other embodiments, a fastening system includes a nonwoven fabric that has a web which is formed of a plurality of extruded strands that include an auto-adhesive material. The fastening system further includes a foam layer that has a surface with a plurality of free-standing struts that include a similar auto-adhesive material. | 12-29-2011 |
20120232511 | Personal Care Articles with Tactile Visual Cues - An absorbent article, for example, a diaper, a training pant, a swimming pant, or a feminine care article, and so forth, includes a topsheet, which forms a body-facing surface of the absorbent article, a backsheet disposed distally from the topsheet, which forms a garment-facing surface of the absorbent article, an absorbent core positioned between the topsheet and the backsheet, and a heat-activatable expandable treatment on the garment-facing surface. The heat-activatable expandable treatment is present on the garment-facing surface in a visually distinctive shape or pattern and provides visual and/or tactile cues to a user of the absorbent article. | 09-13-2012 |
Patent application number | Description | Published |
20100129603 | RETRO-PERCUSSIVE TECHNIQUE FOR CREATING NANOSCALE HOLES - A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes. | 05-27-2010 |
20110111179 | LASER DRILLING TECHNIQUE FOR CREATING NANOSCALE HOLES - A method of forming extremely small pores in a substrate that is used, for example, in patch clamp applications is provided that employs an energy absorbing material beyond a back side of the substrate to allow a laser to be focused adjacent the exit side of the substrate so as to generate a pore through the substrate and can also form a crater in the back side of the substrate and in which the pore may propagate from the crater in a drilling direction that can oppose a laser transmission direction. | 05-12-2011 |
20120064628 | TUBULAR SCAFFOLD FOR NEURAL GROWTH - A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the coaxial axons. Steering electrodes at spaces between tubes may be used to selectively promote the growth of interconnections of different axons in a one, two, or three-dimensional fashion. | 03-15-2012 |
20120141729 | Retro-Percussive Technique for Creating Nanoscale Holes - A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes. | 06-07-2012 |
20130249530 | PIEZOELECTRIC SUBSTRATE FOR THE STUDY OF BIOMOLECULES - A method of forming extremely small pores in a substrate may be used to produce, for example, an apparatus for the study of biological molecules, by providing a small pore in a piezoelectric substrate having electrodes, the latter that may be energized to change the pore dimensions. | 09-26-2013 |
Patent application number | Description | Published |
20110142315 | SYSTEM AND METHOD FOR TOMOGRAPHIC DATA ACQUISITION AND IMAGE RECONSTRUCTION - A tomographic system includes a gantry having an opening for receiving an object to be scanned, a radiation source, a detector positioned to receive radiation from the source that passes through the object, and a computer. The computer is programmed to acquire a plurality of projection datasets of the object, define a temporal subset of projection datasets from the plurality of projection datasets, reconstruct a working image of the object using the plurality of projection datasets, identify a region of motion in the working image, and minimize motion artifacts in the region of motion in the working image using the temporal subset of projection datasets. | 06-16-2011 |
20110150308 | SYSTEM AND METHOD OF ITERATIVE IMAGE RECONSTRUCTION FOR COMPUTED TOMOGRAPHY - A system and method include acquisition of a set of image data corresponding to a time period of data acquisition, the set of image data corresponding to a plurality of voxels, wherein each of the plurality of voxels corresponds to a distinct acquisition time within the time period of data acquisition. The system and method further include the modeling of the plurality of voxels as a function of time based on a plurality of kinetic parameters associated therewith and reconstruction of an image from the set of image data based on the modeled plurality of voxels. | 06-23-2011 |
20130010917 | SYSTEM AND METHOD OF ITERATIVE IMAGE RECONSTRUCTION FOR COMPUTED TOMOGRAPHY - A non-transitory computer readable storage medium having stored thereon a computer program having instructions, which, when executed by a computer, cause the computer to acquire a set of projection data corresponding to a plurality of image voxels and to calculate coefficients of a regularizing function configured to penalize differences between pairs of the plurality of voxels that are not immediate neighbors. The instructions also cause the computer to iteratively reconstruct an image from the set of projection data based on the regularizing function. | 01-10-2013 |
20130108128 | METHOD AND APPARATUS FOR ITERATIVE RECONSTRUCTION | 05-02-2013 |
20130170609 | METHOD AND APPARATUS FOR REDUCING NOISE- RELATED IMAGING ARTIFACTS - A method for reconstructing an image of an object includes acquiring a set of measured projection data, reconstructing the measured projection data using a first algorithm to generate a first reconstructed image dataset, reconstructing the measured projection data using a second algorithm to generate a second reconstructed image dataset, the second algorithm being utilized to improve the temporal resolution of the second reconstructed image dataset, and generating a final image dataset using both the first and second image datasets. | 07-04-2013 |
20130343672 | METHOD AND APPARATUS FOR ITERATIVE RECONSTRUCTION - A method is provided for reconstructing an image of an object that includes image elements. The method includes accessing measurement data associated with the image elements, introducing an auxiliary variable to transform an original problem of reconstructing the image to a constrained optimization problem, and solving the constrained optimization problem using a method of multipliers to create a sequence of sub-problems and solve the sequence of sub-problems. Solving the sequence of sub-problems includes reconstructing the image by optimizing a first objective function. The first objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. An inner loop iteratively optimizes a second objective function approximating the first objective function. An outer loop utilizes the solution of the second objective function to optimize the first objective function. | 12-26-2013 |
20130343673 | METHOD AND APPARATUS FOR ITERATIVE RECONSTRUCTION - A method is provided for iteratively reconstructing an image of an object. The method includes accessing measurement data associated with the image, and using a simultaneous algorithm to reconstruct the image. Using the simultaneous algorithm to reconstruct the image includes determining a scaling factor that is voxel-dependent, and applying the voxel-dependent scaling factor to a gradient of an objective function to reconstruct the image. | 12-26-2013 |
20140369580 | ACCELERATED ITERATIVE RECONSTRUCTION - A framework for an iterative reconstruction algorithm is described which combines two or more of an ordered subset method, a preconditioner method, and a nested loop method. In one type of implementation a nested loop (NL) structure is employed where the inner loop sub-problems are solved using ordered subset (OS) methods. The inner loop may be solved using OS and a preconditioner method. In other implementations, the inner loop problems are created by augmented Lagrangian methods and then solved using OS method. | 12-18-2014 |