Patent application number | Description | Published |
20080318231 | 14-3-3 ZETA OVER-EXPRESSION AS A POOR PROGNOSIS FACTOR, AND A THERAPEUTIC TARGET IN MULTIPLE CANCER TYPE - Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer. | 12-25-2008 |
20110150868 | DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER - Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. | 06-23-2011 |
20120039875 | DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER - Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. | 02-16-2012 |
20130005592 | METHODS AND COMPOSITIONS FOR PREDICTING CANCER THERAPY RESPONSE - The invention generally relates to molecular diagnostics, and particularly to molecular markers for cancer therapy response and methods of use thereof. | 01-03-2013 |
20140112917 | DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER - Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. | 04-24-2014 |
Patent application number | Description | Published |
20080300389 | Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy - The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. | 12-04-2008 |
20090238756 | IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS - Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent. | 09-24-2009 |
20100055035 | BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS - The invention provides, in a general sense, a new labeling strategy employing | 03-04-2010 |
20110087003 | GLYCOPEPTIDE COMPOSITIONS - The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide. | 04-14-2011 |
20130165631 | BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS - The invention provides, in a general sense, a new labeling strategy employing | 06-27-2013 |
20130343995 | EFFICIENT SYNTHESIS OF ETHYLENEDICYSTEINE-SUGAR CONJUGATES FOR IMAGING AND THERAPY - Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia. | 12-26-2013 |
20140200329 | BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS - The invention provides, in a general sense, a new labeling strategy employing | 07-17-2014 |
Patent application number | Description | Published |
20120151384 | SYSTEMS AND METHODS FOR FACILITATING MEDIA CONNECTIONS - A method of connecting consumers with third parties includes providing one or more widgets adjacent a plurality of directory listings of third parties on webpage, with each widget being associated with one of the third parties. An indication can be received that a consumer has executed one of the widgets. The consumer and third party can be connected in a live chat session in response to the execution of the widget. The live chat session can be configured to allow direct communication between the consumer and the third party. | 06-14-2012 |
20130023249 | SYSTEMS AND METHODS FOR FACILITATING MEDIA CONNECTIONS - A method of connecting consumers with third parties includes prompting a user to enter search information on the mobile device about an entity that the user is seeking to contact, conveying information about one or more entities to the user based on retrieved entity information, and initiating a communication connection between the user and the indicated entity. | 01-24-2013 |
20140115683 | SYSTEMS AND METHODS FOR PEER-TO-PEER ONLINE VERIFICATION USING THIRD PARTY AUTHENTICATION - The present disclosure is directed to methods and systems for indicating bias-less trust levels to online users for the purpose of facilitating safe and secure online purchase transactions within an online community. | 04-24-2014 |
20140298479 | SECURE DATA TRANSFER FOR CHAT SYSTEMS - The methods and systems disclosed herein pertain to secure data transfers during live chat sessions. At the conclusion of the chat session, any confidential information exchanged using the secure data transfer can be destroyed to maintain the confidentiality and/or privacy of the content of that information. | 10-02-2014 |
Patent application number | Description | Published |
20120079317 | SYSTEM AND METHOD FOR INFORMATION HANDLING SYSTEM REDUNDANT STORAGE REBUILD - Out-of-order reconstruction of a RAID storage device at a replacement storage device enables the replacement storage device to execute I/O for reconstructed regions during reconstruction of the replacement storage device. In one embodiment, the failed storage device is analyzed to find recoverable information, which is copied to the replacement storage device to reduce the need for reconstruction. In another embodiment, the priority for region's reconstruction is increased upon detection of an I/O to the region. The I/O is queued until reconstruction of the region and then executed after reconstruction of that region so that I/O at the region need not be repeated during reconstruction of the remainder of the replacement storage device. | 03-29-2012 |
20130311683 | SYSTEMS AND METHODS FOR OUT OF BAND NOTIFICATION OF HARD DRIVE STATUS CHANGE - Systems and methods for out of band notification of a hard drive status change may be provided. In accordance with embodiments of the present disclosure, an information handling system may include a processor, a memory communicatively coupled to the processor, a hard disk drive communicatively coupled to the processor via an input/output (I/O) bus for communicating I/O data between the processor and the hard disk drive, and an indicator configured to provide a user-detectable indication of I/O activity occurring on the I/O bus. The hard disk drive may include general purpose input/output (GPIO) terminal independent from the I/O bus and communicatively coupled to the processor, and the hard disk drive may be configured to assert the GPIO terminal in response to an occurrence of a status event of the hard disk drive. | 11-21-2013 |
20130317657 | DRIVE VIBRATION PREVENTION SYSTEM - A drive vibration prevention system includes a fan and a drive. The drive includes a vibration detection device and a vibration notification pin. A management engine is coupled to the drive and the fan. The management engine is operable to determine whether the vibration notification pin is being asserted in response to the vibration detection device detecting a vibration that exceeds a predetermined threshold. In response to determining that the vibration notification pin is being asserted, the management engine retrieves vibration data from the drive. The management engine then modifies a fan speed of the fan using the vibration data. Drives may be grouped into drive groups that output a single vibration notification signal to the management engine, and in response to the assertion of a vibration notification pin in the drive group, the management engine retrieves vibration data from each of the drives in that drive group. | 11-28-2013 |
20140192436 | METHOD AND SYSTEM FOR HARD DISK DRIVE THROUGHPUT OPTIMIZATION USING POSITION ERROR SIGNALING - Systems and methods are provided for throughput optimization of a hard disk drive (HDD) using position error signaling (PES) that includes determining a PES for a HDD mounted in a chassis based on a dynamic disturbance. The method also includes calculating a critical parameter of the PES. The method further includes indicating a mechanical design modification of the HDD or the chassis if the critical parameter of the PES exceeds a pre-defined threshold. | 07-10-2014 |
Patent application number | Description | Published |
20080283725 | Apparatus for Digital Imaging Photodetector Using Gas Electron Multiplier - The present invention provides a digital imaging photodetector with a gas electron multiplier. The digital imaging photodetector comprises a gas electron multiplier detector. The gas electron multiplier detector includes a photoelectric converter for converting incident light into photoelectrons or Compton electrons; a gas electron multiplier (GEM) for receiving the photoelectrons or Compton electrons from the photoelectric converter and multiplying them; and a readout unit for receiving an electrical signal indicating a position where an electron cloud multiplied in the gas electron multiplier arrives on an anode, recognizing coordinates of the electron cloud based on the received signal, and outputting the coordinates of the electron cloud. According to the digital imaging photodetector of the present invention, real-time imaging of image information can be achieved by multiplying photoelectrons or Compton electrons, which are discharged due to a photoelectric effect or a Compton effect induced by visible rays, ultraviolet rays or X-rays, using the gas electron multiplier. | 11-20-2008 |
20090261265 | APPARATUS AND METHOD FOR ARRAY GEM DIGITAL IMAGING RADIATION DETECTOR - An array gas electron multiplier (GEM) digital imaging radiation detector and a control method thereof are disclosed. The array gas electron multiplier (GEM) digital imaging radiation detector includes an array GEM detector. The array GEM detector includes: an ionized electron generation unit for generating ionized electrons in internal filling gas by incident X-rays or gamma rays or by incident charged particles; a gas electron multiplication unit for multiplying the ionized electrons of the ionized electron generation unit in filling gas inside hole of a gas electron multiplier (GEM), through electron avalanche effect, using the GEM, to form electron clouds; a readout for detecting and outputting coordinates of the electron clouds as the readout receives positions through electrical signals, in which the positions of the electron clouds, being multiplied and formed in the gas electron multiplication unit, reach output electrodes. Therefore, the present invention can multiply ionized electrons of internal filling gas as a gas electron multiplier (GEM) generates an electron avalanche effect in the hole thereof, in which the ionized electrons are generated as a photo-electron effect or a Compton effect is induced by high energy incident light, such as X-rays or gamma rays, or which are directly generated by incident charged particles, and can convert image information of the inside or outside of an target object into images of two-dimensions, in real time, such that the detector can be properly used as a security search apparatus in a harbor or an airport, or can be adapted as a core part of industrial nondestructive testing apparatus. | 10-22-2009 |
Patent application number | Description | Published |
20090297043 | PATTERN SCANNER AND EDITOR FOR SECURITY AUDIT SYSTEMS - A pattern scanner is provided for identifying which portions of a security log entry is unrecognizable by currently defined data patterns. Furthermore, an editor is provided for identifying portions of the security log entry that are recognizable by sub-patterns of the currently defined data patterns and portions of the security log entry that are not recognizable. The editor further provides a user interface through which a user may associated sub-patterns with portions of the security log entry that are not recognized. Moreover, a user interface may be provided for defining new sub-patterns that may be applied to recognizing portions of security log entries. A data pattern based on a combination of sub-patterns for the recognized and unrecognized portions of the security log entry may then be automatically generated. | 12-03-2009 |
20110047537 | Updating client node of computing system - During execution of an existing scheduling computer program on a client node, an update computer program and a self-describing automatic installation package are downloaded to the client node from a logical depot node implemented on an existing management server. Therefore, advantageously, no physical depot node or other additional computing device is needed for the client node to update itself. Execution of the update computer program is spawned on the client node from the existing scheduling computer program. As such, the update computer program inherits root access to the client node and security credentials to the management server from the scheduling computer program—advantageously, then, a user does not have to perform any laborious configuration of the client node in order to update the node. The client node ultimately updates itself using the self-describing automatic installation package, which includes all the information needed for the client node to update itself. | 02-24-2011 |
20110154370 | Microblogging Based Dynamic Transaction Tracking for Composite Application Flow - Using microblogging to dynamically track event flow of a composite enterprise application by reporting an enterprise application event. A client server detects an event of the complex enterprise application, and encodes the event data in a microblog compatible format. The client computer creates an event post message containing the event data and uploads the event post to a microblog server via the Internet. The microblog server then displays the post message in a user readable format. | 06-23-2011 |
20120150810 | Backing up data objects identified by search program and corresponding to search query - A backup program running on a computing device receives a search query. The backup program transmits the search query to a search program. The backup program receives search results corresponding to the search query from the search program. The search results include a list of data objects stored on a storage device and that satisfy the search query. The backup program backs up one or more selected data objects of the list of data objects. The backup program can periodically and automatically without user interaction retransmit the search query to the search program, and receive updated search results corresponding to the search query from the search program. The updated search results include an updated list of data objects stored on the storage device that satisfy the search query. The backup program can then back up the data objects within the updated list of data objects. | 06-14-2012 |
20140006498 | Data De-Duplication in Service Oriented Architecture and Web Services Environment | 01-02-2014 |
Patent application number | Description | Published |
20090070779 | MINIMIZING MESSAGE FLOW WAIT TIME FOR MANAGEMENT USER EXITS IN A MESSAGE BROKER APPLICATION - A method for minimizing the message flow wait time for management user exits in a message broker application. A message broker application processes a request in a request and a response message flow. The request message flow generates a request identifier, collects information about the request message flow, and stores the request identifier and information in a global data map. The response message flow uses the request identifier to access the map and read the collected information without having to acquire a lock on the map. The response message flow also collects information about the response message flow, and generates management information about the request based on the information about the request message flow and the information about the response message flow. A dedicated clean up thread in the message broker application is used to remove used items from the global data map. | 03-12-2009 |
20090144714 | AUTOMATIC DEPLOYMENT OF JAVA CLASSES USING BYTE CODE INSTRUMENTATION - A computer implemented method, data processing system, and computer program product for Java class automatic deployment using byte code instrumentation technology. One or more classloaders are instrumented with byte code instrumentation code such that a class loading event is received when a class is loaded. If a determination is made that new byte code instrumentation code needs to be loaded with the loaded class, candidate classloaders that load import classes of the new byte code instrumentation code are determined. A correct classloader from the candidate classloaders to load the new byte code instrumentation code is calculated. The correct classloader is instrumented to have an extended classpath, wherein the new byte code instrumentation code is inserted into the extended classpath of the correct classloader. The class is loaded from the extended classpath and original classpath of the correct classloader. | 06-04-2009 |
20090144751 | AUTOMATIC DISCOVERY OF THE JAVA CLASSLOADER DELEGATION HIERARCHY - A computer implemented method, data processing system, and computer program product for automatic discovery of the Java classloader delegation hierarchy. One or more classloaders are instrumented with byte code instrumentation code such that a delegation event is received each time a classloader delegates a resource finding method to a parent classloader of the classloader. From each delegation event received, the classloader that generated the delegation event and a parent classloader to which the classloader directly delegates the resource finding method is determined. Based on the delegation events received, the classloaders to which a current classloader in the one or more classloaders can directly delegate are determined. The order of delegation to the classloaders may then be determined. | 06-04-2009 |
20090182816 | METHOD AND SYSTEM FOR MANAGING J2EE AND .NET INTEROPERATING APPLICATIONS - A computer implemented method, system, and computer usable program code for managing a transaction between a service client and a service provider is provided. A request from a Web services client application is received. A correlation token and a unique transaction handle associated with the correlation token are extracted from the request, forming an extracted correlation token and an extracted transaction handle. A child correlation token is generated using the extracted correlation token as a parent correlation token. A unique transaction handle associated with the child correlation token is generated. A timer associated with the unique transaction handle and child correlation token is started. The request is performed. The timer associated with the unique transaction handle is stopped. The extracted transaction handle is inserted in a response to the request. The response with the extracted transaction handle is transmitted to a Web services client application. | 07-16-2009 |
Patent application number | Description | Published |
20120273281 | METHODS OF ATTACHING ROLLING CUTTERS IN FIXED CUTTER BITS USING SLEEVE, COMPRESSION SPRING, AND/OR PIN(S)/BALL(S) - A cutting element is disclosed that has a sleeve with a first inner diameter and a second inner diameter, wherein the second inner diameter is larger than the first inner diameter and located at a lower axial position than the first inner diameter, a rotatable cutting element having an axis of rotation extending therethrough, the rotatable cutting element at least partially disposed within the sleeve, wherein the rotatable cutting element has a cutting face and a body extending axially downward from the cutting face, at least one hole extending from an outer surface of the body toward the axis of rotation, and a locking device disposed in each hole, wherein the locking device protrudes from the hole to contact the second inner diameter of the sleeve, thereby retaining the rotatable cutting element within the sleeve. | 11-01-2012 |
20140110181 | METHODS FOR DESIGNING FIXED CUTTER BITS AND BITS MADE USING SUCH METHODS - Embodiments disclosed herein relate to a method for analyzing a fixed cutter drill bit, said method including selecting a cutter; selecting an earth formation; simulating drilling performance of the fixed cutter bit having at least once cutter thereon; performing finite element analysis using outputs from the simulating; and outputting stress on the at least one cutter. | 04-24-2014 |
20140262537 | CUTTING ELEMENT WITH IMPROVED SUBSTRATE MATERIAL - Cutting elements comprise a body and a polycrystalline diamond table disposed thereon, wherein the diamond table has a thickness of greater than about 2 mm. The body is specially formed from WC—Co and has a Co content of equal to or less than about 10 weight percent based on the total weight of the WC—Co, a coefficient of thermal expansion that is less than about 5×10 | 09-18-2014 |
20140345951 | ROLLING CUTTER - A cutting element for a drill bit that includes an outer support element having at least a bottom portion and a side portion; and an inner rotatable cutting element, a portion of which is disposed in the outer support element, wherein the inner rotatable cutting element includes a substrate and a diamond cutting face having a thickness of at least 0.050 inches disposed on an upper surface of the substrate; and wherein a distance from an upper surface of the diamond cutting face to a bearing surface between the inner rotatable cutting element and the outer support element ranges from 0 to about 0.300 inches is disclosed. | 11-27-2014 |
20140353046 | HYBRID BIT WITH ROLLER CONES NEAR THE BIT AXIS - A drill bit includes a bit body having a longitudinal axis extending there through, a plurality of journals extending downward and radially outward from the bit body, each journal having a journal axis extending from a base of the journal through the length of the journal, wherein the journal axis at the base is at a first radial distance from the longitudinal axis, a roller cone rotatably mounted to each of the journals, and at least one blade protruding from the bit body and extending axially and radially along the bit body from a first end to a second end, wherein the first end is at a second radial distance from the longitudinal axis greater than the first radial distance, and wherein the second end is at a gage region of the drill bit. | 12-04-2014 |
Patent application number | Description | Published |
20100219001 | ROLLING CUTTER - A cutting element for a drill bit that includes an outer support element having at least a bottom portion and a side portion; and an inner rotatable cutting element, a portion of which is disposed in the outer support element, wherein the inner rotatable cutting element includes a substrate and a diamond cutting face having a thickness of at least 0.050 inches disposed on an upper surface of the substrate; and wherein a distance from an upper surface of the diamond cutting face to a bearing surface between the inner rotatable cutting element and the outer support element ranges from 0 to about 0.300 inches is disclosed. | 09-02-2010 |
20120073881 | ROLLING CUTTER - A cutting element for a drill bit that includes an outer support element having at least a bottom portion and a side portion; and an inner rotatable cutting element, a portion of which is disposed in the outer support element, wherein the inner rotatable cutting element includes a substrate and a diamond cutting face having a thickness of at least 0.050 inches disposed on an upper surface of the substrate; and wherein a distance from an upper surface of the diamond cutting face to a bearing surface between the inner rotatable cutting element and the outer support element ranges from 0 to about 0.300 inches is disclosed. | 03-29-2012 |
20130220707 | ROLLING CUTTER - A cutting element for a drill bit that includes an outer support element having at least a bottom portion and a side portion; and an inner rotatable cutting element, a portion of which is disposed in the outer support element, wherein the inner rotatable cutting element includes a substrate and a diamond cutting face having a thickness of at least 0.050 inches disposed on an upper surface of the substrate; and wherein a distance from an upper surface of the diamond cutting face to a bearing surface between the inner rotatable cutting element and the outer support element ranges from 0 to about 0.300 inches is disclosed. | 08-29-2013 |
Patent application number | Description | Published |
20120227033 | METHOD AND APPARATUS FOR EVALUATING SOFTWARE PERFORMANCE - A method and apparatus are provided for evaluating called routines in a computer program. The method comprises periodically interrupting execution of a computer program. One or more entries in a call stack is then inspected to identify one or more possible call operations. The one or more possible call operations is then validated as an actual call entry based on the possible call entry being associated with a code segment in a program module. Data regarding each validated call entry identified during each of the periodic interrupts is collected and may be presented to a computer user. | 09-06-2012 |
20130019248 | METHOD AND APPARATUS FOR MONITORING AND SHARING PERFORMANCE RESOURCES OF A PROCESSORAANM Yu; LeiAACI AustinAAST TXAACO USAAGP Yu; Lei Austin TX US - A method and apparatus are described for managing a plurality of performance monitoring resources residing in a plurality of cores of a processor. A plurality of resource queues are maintained. Each resource queue corresponds to a particular one of the performance monitoring resources, and detects conflicts in use of the particular performance monitoring resource by multiple users. The detected conflicts associated with the particular performance monitoring resource are then resolved. A dynamic resource scheduler is used to resolve the detected conflicts, and is driven by an advanced programmable interrupt controller (APIC) timer residing in a particular core of the processor to provide each item, in an items list of a resource queue associated with the particular performance monitoring resource, an equal opportunity to use the particular performance monitoring resource for a predetermined period of time. | 01-17-2013 |
20130227221 | CACHE ACCESS ANALYZER - A performance monitor records performance information for tagged instructions being executed at an instruction pipeline. For instructions resulting in a load or store operation, a cache access analyzer can decompose the address associated with the operation to determine which cache line, if any, of a cache is accessed by the operation, and which portion of the cache line is requested by the operation. The cache access analyzer records the cache line portion in a data record, and, in response to a change in instruction being executed, stores the data record for subsequent analysis. | 08-29-2013 |
Patent application number | Description | Published |
20100115068 | Methods and systems for intelligent reconfiguration of information handling system networks - Methods and systems for automatically and/or intelligently reconfiguring a configuration of networked information handling systems based on change/s in user requirement values. A user may be allowed to adapt a system configuration originally recommended, for example, by a conventional configuration tool in order to meet a given set of user requirement parameters, or to optimize such a recommended configuration for the user. A user may be provided with a recommendation of which user requirement parameter/s needs to be changed (and optionally by how much a value of the user requirement parameter/s needs to be changed) in order to achieve a targeted networked system configuration, i.e., by changing a specific information handling system configuration variable/s. | 05-06-2010 |
20110119251 | System and Method for SQL Query Load Balancing - Systems and methods for SQL query load balancing are disclosed. A method may include establishing a ranking scheme, assigning a rank to an SQL query from the ranking scheme based on a plurality of rank assignment parameters, determining a threshold rank based on a plurality of gathered operational characteristics, comparing the assigned rank to the threshold rank, and, if the assigned rank is greater than the threshold rank, executing the SQL query on a database server. Otherwise, if the assigned rank is not greater than the threshold rank, executing the SQL query on a centralized storage system. | 05-19-2011 |
Patent application number | Description | Published |
20100093974 | Linkers and Co-Coupling Agents for Optimization of Oligonucleotide Synthesis and Purification on Solid Supports - A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications. | 04-15-2010 |
20100210478 | MAKE AND USE OF SURFACE MOLECULES OF VARIED DENSITIES - The present invention relates to quantitative and quantity aspects of array synthesis and array uses as a device for high capacity producing synthetic molecules for off-array surface applications and as an assay device for on-array surface applications. | 08-19-2010 |
20110097762 | LINKERS AND CO-COUPLING AGENTS FOR OPTIMIZATION OF OLIGONUCLEOTIDE SYNTHESIS AND PURIFICATION ON SOLID SUPPORTS - A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications. | 04-28-2011 |
20110288285 | Novel reagent compounds and methods of making same - The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine. | 11-24-2011 |
20120029166 | LINKERS AND CO-COUPLING AGENTS FOR OPTIMIZATION OF OLIGONUCLEOTIDE SYNTHESIS AND PURIFICATION ON SOLID SUPPORTS - A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications. | 02-02-2012 |
Patent application number | Description | Published |
20130226461 | METHOD FOR REAL-TIME DOWNHOLE PROCESSING AND DETECTION OF BED BOUNDARY FOR GEOSTEERING APPLICATION - In some embodiments, an apparatus and a system, as well as a method and an article, may operate to acquire input data to determine properties of a formation, using a combination of down hole transmitters and receivers, to select a portion of the input data using a formation model chosen from a plurality of down hole tool response models in a formation model database, based on a valid sensitive range for the bed boundary distance and a greatest signal-to-noise ratio (SNR), and to solve for at least resistivity formation parameters in the properties using the chosen formation model and the selected portion of the input data. The database may be updated with boundary distance and the resistivity formation parameters. Additional apparatus, systems, and methods are disclosed. | 08-29-2013 |
20150047902 | SYSTEMS AND METHODS OF ROBUST DETERMINATION OF BOUNDARIES - Various embodiments include apparatus and methods to operate a drilling operation relative to formation boundaries. The apparatus and methods can include operating one or more transmitters in a borehole in a formation having a thickness between two boundaries, selecting thickness models based on applying responses from operating the one or more transmitters such that the thickness of the formation is between the two thickness models, and generating a value of a distance to a nearest boundary based on linearization of the thickness models with respect to a long distance investigation parameter and a short distance investigation parameter. Additional apparatus, systems, and methods are disclosed. | 02-19-2015 |