Yoshikazu Sugimoto
Yoshikazu Sugimoto, Chiba JP
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20080249036 | Antagonist Against Tolerance to Anticancer Drugs - An ABC transporter protein expression inhibitor comprising, as the active ingredient(s), 0.001 to 100 nM of one or more members selected from among steroid hormones, compounds having a female hormone function, analogous compounds thereof and antagonistic inhibitors therefor; an anticancer composition containing this ABC transporter protein expression inhibitor and an anticancer drug; and cells useful in the development of an anticancer drug. The present invention provides a drug which inhibits the expression of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs. | 10-09-2008 |
20080287374 | BREAST CANCER-RESISTANT PROTEIN INHIBITOR - The invention provides a cancer cell useful in screening BCRP-inhibitors, and a BCRP-inhibitor. | 11-20-2008 |
20090239936 | Prophylactic and Therapeutic Agent for Cancer - A Ras, Raf, MEK, ERK or RSK inhibitor, namely a P-glycoprotein expression inhibitor or a BCRP expression inhibitor, can be screened by utilizing the MAPK signaling activity as an indicator. It becomes possible to provide an anticancer agent which is reduced in resistance acquisition, and also provide an agent for preventing the resistance against an anticancer agent, which can enhance the therapeutic effect of the anticancer agent against cancer. | 09-24-2009 |
20090253656 | BCRP/ABCG2 INHIBITOR - The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. | 10-08-2009 |
20100249089 | ABCG2 INHIBITOR - The present invention relates to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. | 09-30-2010 |
20110097335 | ABC TRANSPORTER PROTEIN EXPRESSION INHIBITOR - Provided is a novel drug which exhibits excellent effect of inhibiting expression of an ABC transporter protein, as well as improved safety. | 04-28-2011 |
Yoshikazu Sugimoto, Osaka JP
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20100309769 | OPTICAL PICKUP - In an optical pickup, a photo receiving portion for receiving returned light reflected by an optical disc is adhered and fixed to an optical base. The photo receiving portion has a photodetector and a plate on which the photodetector is loaded. The plate is fixed onto the optical base by adhesive such that the photo receiving portion is adhered and fixed to the optical base. The plate is in a substantially circular shape in plan view. | 12-09-2010 |
Yoshikazu Sugimoto, Kashiwa-Shi JP
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20100291242 | ANTAGONIST AGAINST TOLERANCE TO ANTICANCER DRUGS - An ABC transporter protein expression inhibitor comprising, as the active ingredient(s), 0.001 to 100 nM of one or more members selected from among steroid hormones, compounds having a female hormone function, analogous compounds thereof and antagonistic inhibitors therefor; an anticancer composition containing this ABC transporter protein expression inhibitor and an anticancer drug; and cells useful in the development of an anticancer drug. The present invention provides a drug which inhibits the expression of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs. | 11-18-2010 |
Yoshikazu Sugimoto, Tokyo JP
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20100240682 | PHOPHYLACTIC OR THERAPEUTIC AGENT FOR INFLAMATORY DISEASE COMPRISING THYMIDINE PHOSPHORYLASE INHIBITOR AS ACTIVE INGREDIENT - To provide an excellent agent for prevention or treatment of an inflammatory disease. | 09-23-2010 |
Yoshikazu Sugimoto, Nishishirakawa-Gun JP
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20090311705 | METHOD OF DETERMINING EFFICIENCY OF OVUM COLLECTION IN BOVINE - The novel means by which an efficiency of ovum collection can be easily determined in bovine at gene level is disclosed. The present inventors performed the genomic linkage analysis using bovine populations with high and low efficiency of ovum collection and to identify GRIA1 gene, which encodes an ion channel protein, as a factor deeply related to an efficiency of ovum collection. Bovines having a mutation (e.g. the amino acid substitution of aa306) in GRIA1 produce significantly fewer ova on superovulatory treatment than those not having the mutation. Therefore, the efficiency of ovum collection can be determined based on the existence of a mutation in GRIA1 gene. | 12-17-2009 |
Yoshikazu Sugimoto, Tokushima JP
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20090208982 | ASSAY METHOD FOR HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE PROTEIN - To establish an immunoassay method for human OPRT. | 08-20-2009 |