Patent application number | Description | Published |
20080237151 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - A centrifugal force-based microfluidic device in which a sample including particles and a fluid is centrifugally separated such that the separated fluid is quantitatively distributed, and a microfluidic system including the centrifugal force-based microfluidic device are provided. The centrifugal force-based microfluidic device includes a microfluidic structure in which, within a rotatable disc-shaped platform, a sample, including particles and a fluid, is quickly centrifugally separated into the particles and the fluid using the rotation of the disc-shaped platform and the fluid having a certain volume of the separated fluid is discharged by rotation of the disc-shaped platform. | 10-02-2008 |
20080269077 | CENTRIFUGAL MICROFLUIDIC DEVICE HAVING SAMPLE DISTRIBUTION STRUCTURE AND CENTRIFUGAL MICROFLUIDIC SYSTEM INCLUDING THE CENTRIFUGAL MICROFLUIDIC DEVICE - Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal microfluidic device includes: a rotatable platform; a sample chamber which is disposed in the rotatable platform and houses a fluid sample; a distribution channel connected to an outlet of the sample chamber; a valve which is disposed in the outlet of the sample chamber; a plurality of non-vented reaction chambers which are disposed in the rotatable platform outside of the distribution channel in the radial direction; and a plurality of inlet channels connecting the distribution channel with the reaction chambers. | 10-30-2008 |
20080273205 | OPTICAL DETECTION APPARATUS AND METHOD USING PHASE SENSITIVE DETECTION METHOD FOR DISK-TYPE MICROFLUIDIC DEVICE - An optical detection apparatus and method using a phase sensitive detection method for a disk-type microfluidic device are provided. The optical detection apparatus includes: a rotation driving unit stopping rotation of the microfluidic device when a detection area of the disk-type microfluidic device reaches a predetermined position; at least one light source turned on and off at a corresponding frequency to emit light to the detection area held at the predetermined position; an optical sensor disposed to face the detection area and generating an electrical signal according to intensity of incident light; and a signal processing unit receiving the electrical signal generated by the optical sensor and outputting only a signal having a same frequency as an on/off frequency of one of the at least one light source. | 11-06-2008 |
20080300148 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 12-04-2008 |
20080305006 | MICROFLUIDIC APPARATUS HAVING FLUID CONTAINER - A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container. | 12-11-2008 |
20080314465 | MICROFLUIDIC VALVE, METHOD OF MANUFACTURING THE SAME, AND MICROFLUIDIC DEVICE COMPRISING THE MICROFLUIDIC VALVE - Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves. | 12-25-2008 |
20090035847 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Provided are a centrifugal force-based microfluidic device for separating and amplifying a nucleic acid of a target cell and a microfluidic system including the same. The microfluidic device includes a rotary platform; a target cell nucleic acid extraction unit; and a polymerase chain reaction (PCR) unit wherein in a microfluidic structure arranged in the platform and connected to the target cell nucleic acid extraction unit. | 02-05-2009 |
20090053108 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR BLOOD CHEMISTRY ANALYSIS - Provided is a microfluidic device that can automatically perform various types of biological blood analysis. In the microfluidic device, a specimen is centrifugally separated and the centrifugally separated specimen is diluted into various dilution ratios. Also, at least two reagents that are required for one reaction and that need to be separately stored are stored in separate chambers, and they are mixed when a reaction is needed. Thus, various conventional blood analyzing reagents can be used as they are or after being minimally processed in the microfluidic device. | 02-26-2009 |
20090099782 | AUTOMATIC ANALYZING METHOD AND APPARATUS FOR MICROFLUIDIC SYSTEM - Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantitation of a test. | 04-16-2009 |
20090143250 | MICROFLUIDIC DEVICE USING MICROFLUIDIC CHIP AND MICROFLUIDIC DEVICE USING BIOMOLECULE MICROARRAY CHIP - Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure. | 06-04-2009 |
20100009457 | MICROFLUIDIC DEVICE, SAMPLE ANALYZING METHOD USING THE SAME, AND DILUTION RATIO MEASURING METHOD - Provided are a microfluidic device, a method of analyzing a sample using the microfluidic device, and a method of measuring dilution ratios. The microfluidic device includes: a sample chamber which accommodates a sample to be tested; a dilution chamber which accommodates a diluent, receives the sample from the sample chamber, and provides a sample diluent; a first concentration detecting chamber which receives the sample from the sample chamber; and a second concentration detecting chamber which receives the sample diluent from the dilution chamber. | 01-14-2010 |
20100015695 | METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS - A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate. | 01-21-2010 |
20100021972 | METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS - A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate. | 01-28-2010 |
20100093105 | MICROFLUIDIC DEVICE USING CENTRIFUGAL FORCE, METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE AND SAMPLE ANALYZING METHOD USING THE MICROFLUIDIC DEVICE - Provided is a microfluidic device including: a sample chamber; at least one analyzing unit receiving a sample from the sample chamber and detecting components contained in the sample according to a reaction of the sample and a reagent; and a denaturation detection chamber determining the storage condition of the microfluidic device, wherein the denaturation detection chamber accommodates a material whose light absorption changes according to the temperature and the water thereof | 04-15-2010 |
20100290955 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR BLOOD CHEMISTRY ANALYSIS - Provided is a microfluidic device that can automatically perform various types of biological blood analysis. In the microfluidic device, a specimen is centrifugally separated and the centrifugally separated specimen is diluted into various dilution ratios. Also, at least two reagents that are required for one reaction and that need to be separately stored are stored in separate chambers, and they are mixed when a reaction is needed. Thus, various conventional blood analyzing reagents can be used as they are or after being minimally processed in the microfluidic device. | 11-18-2010 |
20100311070 | POLYMERASE CHAIN REACTION (PCR) MODULE AND MULTIPLE PCR SYSTEM USING THE SAME - Provided are a PCR module and a multiple PCR system using the same. More particularly, provided are a PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same. | 12-09-2010 |
20110020194 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction. | 01-27-2011 |
20110049398 | VALVE UNIT AND APPARATUS HAVING THE SAME - A valve unit and an apparatus having the same include a plug which includes a phase change material in a solid state at a room temperature and a plurality of fine heat-dissipating particles dispersed in the phase change material. The fine heat-dissipating particles dispersed in the phase change material dissipate heat by absorbing an electromagnetic wave energy generated by electromagnetic wave radiation from the outside and block fluid flow in a path formed by a channel. As an external energy source irradiates an electromagnetic wave on the plug, the plurality of fine heat-dissipating particles dissipate heat and the phase change material becomes molten, thus opening the path to allow the fluid to flow. | 03-03-2011 |
20110085950 | CENTRIFUGAL FORCE BASED MICROFLUIDIC SYSTEM AND BIO CARTRIDGE FOR THE MICROFLUIDIC SYSTEM - A microfluidic system based on centrifugal force and a bio cartridge for the microfluidic system are provided. The system includes a spindle motor, a rotatable frame detachably mounted on the motor and having a plurality of cells separated by partition walls, and the bio cartridge detachably accommodated in one of the plurality of cells. The bio cartridge includes a chamber for storing a fluid, a channel for transporting the fluid, and a valve for controlling the flow of the fluid. The valve may include a phase transition material, and exothermic minute particles dispersed in the material and generating heat when energy is applied thereto. | 04-14-2011 |
20110089034 | DIELECTROPHORESIS APPARATUS INCLUDING CONCENTRATION GRADIENT GENERATING UNIT, METHOD OF SEPARATING MATERIAL USING THE SAME, AND METHOD OF SCREENING CONDITION FOR SEPARATING MATERIAL - A dielectrophoresis (DEP) apparatus including a concentration gradient generating unit, a method of separating a target material in a sample solution using the DEP apparatus, and a method of screening the optimum condition for separating a target material are provided. | 04-21-2011 |
20110201101 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction. | 08-18-2011 |
20110232832 | MICROFLUIDIC VALVE, METHOD OF MANUFACTURING THE SAME, AND MICROFLUIDIC DEVICE COMPRISING THE MICROFLUIDIC VALVE - Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves. | 09-29-2011 |
20110256026 | MICRO-FLUIDIC DEVICE AND SAMPLE TESTING APPARATUS USING THE SAME - A microfluidic device having a delay structure and a sample testing apparatus including the microfluidic device are provided. The microfluidic device includes: a reaction chamber which contains a reagent capable of reacting with a sample; a distribution channel through which the sample is provided to the reaction chamber; an inlet channel through which the at least one reaction chamber is connected with the distribution channel; and a delay structure which is located between the at least one reaction chamber and the distribution channel, and delays movement of contents of the reaction chamber to the distribution channel. | 10-20-2011 |
20110257037 | MICROFLUIDIC DEVICE USING MICROFLUIDIC CHIP AND MICROFLUIDIC DEVICE USING BIOMOLECULE MICROARRAY CHIP - Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure. | 10-20-2011 |
20120028830 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 02-02-2012 |
20120028850 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 02-02-2012 |
20120028851 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 02-02-2012 |
20120028852 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 02-02-2012 |
20120322132 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID EXTRACTION AND MICROFLUIDIC SYSTEM INCLUDING THE MICROFLUIDIC DEVICE - A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves. | 12-20-2012 |