Patent application number | Description | Published |
20110152258 | Compounds and Methods for Kinase Modulation, and Indications Therefor - Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease. | 06-23-2011 |
20110263595 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors. | 10-27-2011 |
20140128373 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. | 05-08-2014 |
20140128390 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases. | 05-08-2014 |
20140213554 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases. | 07-31-2014 |
20140241247 | IMPLEMENTING A 3G PACKET CORE IN A CLOUD COMPUTER WITH OPENFLOW DATA AND CONTROL PLANES - A control plane device in a cloud computing system executes a plurality of virtual machines for implementing network function virtualization (NFV). The control plane device is operable to manage implementation of a general packet radio service (GPRS) tunnel protocol (GTP) in a packet core (PC) of a third generation (3G) network having a split architecture where a control plane of the PC of the 3G network is in the cloud computing system. The control plane communicates with a data plane of the PC through a control plane protocol. The data plane is implemented in a plurality of network devices of the 3G network. The control plane device and the plurality of virtual machines are operable to communicate with other control plane devices in the cloud computing system and with the plurality of network devices of the data plane. | 08-28-2014 |
20140288070 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR - Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease. | 09-25-2014 |
20140321330 | CONTROLLER PLACEMENT FOR FAST FAILOVER IN THE SPLIT ARCHITECTURE - A method implemented by a network topology design system, the network topology design system including a processing device. The method to determine placement of a controller within a network with a split architecture where control plane components of the split architecture network are executed by a controller and the control plane components are separate from data plane components of the split architecture network. The placement of the controller is selected to minimize disruption of the split architecture network caused by a link failure, a switch failure or a connectivity loss between the controller and the data plane components. | 10-30-2014 |
20140355453 | METHOD AND ARRANGEMENT FOR FAULT ANALYSIS IN A MULTI-LAYER NETWORK - The invention relates to a method for fault analysis in a multi-layer network. The method includes receiving a first set of performance measurements occurring in response to the fault and representing at least a first and a second layer in a multi-layer communications network. A probable set of network elements affected by the fault are localized. The type of fault is inferred from one or more symptoms in the performance measurements. The root cause of the failure is determined from a combination of information on probable set of network elements and inferred type of fault. | 12-04-2014 |
20140379891 | Methods and Apparatuses to Identify User Dissatisfaction from Early Cancelation - In the present disclosure methods and apparatuses for identifying web page transactions causing user dissatisfaction is presented. The description disclose method steps and means for determining at least one network characteristic for all transactions associated with a web page and said user, determining a network characteristics function dependent on said at least one network characteristic using the transactions not associated with cancellations and for each cancelled transaction determining a value indicative of if said cancelled transaction was a result of user dissatisfaction by comparing said at least one network characteristic for said cancelled transaction with a value derived from said network characteristics function. | 12-25-2014 |
20150067170 | METHOD AND SYSTEM TO ALLOCATE BANDWIDTH BASED ON TASK DEADLINE IN CLOUD COMPUTING NETWORKS - A method implemented to provide a virtual network to tenants requiring bandwidth in a cloud computing environment is disclosed. The method starts with receiving a request for a task at a network device, the request including a first parameter indicating VMs required, a second parameter indicating bandwidths the required VMs need, a third parameter indicating a duration of the task, and a fourth parameter indicating a deadline of the task. The network device then selects a starting time and a bandwidth allocation of the task, where the bandwidth allocation is shrank to be smaller than the second parameter indicating, and where the selection aims at minimizing a measurement of cloud resource utilization considering consumptions of both VMs and bandwidth. Then the network device allocates VMs for the request at the starting time with the bandwidth allocated at a particular location in the cloud computing environment. | 03-05-2015 |
20150081855 | SYSTEM AND METHOD FOR ASSIGNING MULTI-INSTANCE SERVICES IN A PROVIDER NETWORK - A system and method for placing inline services having multiple instances in a service provider network. In one implementation, a topology of the service provider network and services to be placed therein are defined, wherein a network node may include a data forwarding functionality and a control plane functionality. Using service chaining policy requirements, the number of service instances, etc. as input, services and their multiple instances are placed within the network such that an overall network metric is optimized for all subscriber data flows. | 03-19-2015 |