Yaworsky
Paul Yaworsky, Boston, MA US
Patent application number | Description | Published |
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20090202474 | EXPRESSION OF ORPHAN GPR64 IN INFLAMMATORY DISEASES - Methods of screening for agents for treating inflammatory diseases are provided. The methods involve screening for agents that modulate the activity or expression of GPR64, which has been discovered herein to play a role in inflammatory diseases. Methods for treating an inflammatory disease, as well as methods of modulating the activity or expression of GPR64, methods of screening for an inflammatory disease in a subject, pharmaceutical compositions, a nucleic acid variant, and antibodies are also provided. | 08-13-2009 |
Paul J. Yaworsky, Rockland, MA US
Patent application number | Description | Published |
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20090136507 | HBM variants that modulate bone mass and lipid levels - The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis. | 05-28-2009 |
Paul John Yaworsky, Boston, MA US
Patent application number | Description | Published |
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20090087431 | METHODS OF TREATING BONE DISORDERS WITH MODULATORS OF AXL - The invention provides methods for treating or preventing bone and cartilage disorders comprising administering to a mammal an inhibitor of Axl gene expression or an inhibitor of Axl protein activity. | 04-02-2009 |
20100286071 | Finger-1 Peptide Analogs of the TGF-Beta Superfamily - Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics. | 11-11-2010 |