Patent application number | Description | Published |
20080207666 | Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators - Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness. | 08-28-2008 |
20080249093 | (3,4-Disubstituted)Propanoic Carboxylates as Sip (Edg) Receptor Agonists - The present invention encompasses compounds of Formula I: | 10-09-2008 |
20090042954 | 2-(Aryl)Azacyclylmethyl Carboxylates, Sulfonates, Phosphonates, Phosphinates and Heterocycles as S1p Receptor Antagonists - The present invention encompasses compounds of Formula I: | 02-12-2009 |
20090312307 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION - Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the K | 12-17-2009 |
20100029678 | DIURETICS - A compound having the structure | 02-04-2010 |
20120202845 | DIURETICS - A compound having the structure formula (I) or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension. | 08-09-2012 |
20120208838 | DIURETICS - A compound having the structure (I) wherein R is selected from the group consisting of 1) and 2), or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension. | 08-16-2012 |
20120232039 | PRIMARY AMINE DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES - A compound having the structure | 09-13-2012 |
20130059823 | Diazeniumdiolate Cyclohexyl Derivatives - A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R | 03-07-2013 |
20130289003 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES - A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy. | 10-31-2013 |
20140088048 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES - A compound having the structure | 03-27-2014 |
20150105317 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES - Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A. | 04-16-2015 |
Patent application number | Description | Published |
20130231080 | METHOD AND SYSTEM TO PROVIDE NETWORK STATUS INFORMATION TO A DEVICE - Network status information is provided to a mobile device. The data usage of the mobile device is tracked. A data usage criterion is determined from an account for the mobile device. The account information is stored on at least one server. The data usage is compared with the data usage criterion. Based on the comparison, it is determined whether the data usage meets the data usage criterion. Upon determining that the data usage meets the data usage criterion, a notification message is sent to the mobile device in real time through an information element field within an existing message in a bearer channel of the wireless packet data communication network. The notification message may instruct the mobile device to prevent generation and/or transmission of automatic network access requests while allowing user-initiated network access requests. | 09-05-2013 |
20140045474 | SELF-ACTIVATION THROUGH A NON-ACTIVATED DEVICE - A method of permitting self-activation of a mobile device is presented. The device is able to be activated without accessing the Internet or relying on a customer service representative when a device with a SIM card is initially powered on. A device client resident on the mobile device detects that the SIM card is self-activation capable, and then provides a customized interface to walk the user through a self-activation process. The interface provides various features associated with the communication functionality of the device, whether or not the functionality is dependent on the make and model of the mobile device. | 02-13-2014 |
20140187199 | METHOD AND SYSTEM TO IMPROVE DEVICE PINGING - A method and system are provided for determining the network status of a mobile device. A wireless connection between the mobile device and a wireless packet data communication network is established. The mobile device sends a data packet through the network and monitors for a response via the network one or more times within a period or until a response via the network is received. If no response is received via the network, a test message is sent to a dummy server a predetermined number of times within a period or until a response from the dummy server is received. Upon determining that a response from the dummy server has been received, the mobile device deactivates or blocks network access requests originating from the mobile device to the network, unless initiated by a user of the mobile device. | 07-03-2014 |
20140189790 | PROVIDING MULTIPLE APN CONNECTIONS SUPPORT IN A BROWSER - At a web browser application installed on a device a first Uniform Resource Locator (URL) is received. The web browser application determines a first Access Point Name (APN) network identifier associated with the first URL and establishes a first data connection based on the first APN network identifier between the device and a network. At the web browser application installed on the device a second URL is received. The web browser application determines a second Access Point Name (APN) network identifier associated with the second URL and establishes a second data connection based on the second APN network identifier between the device and a network. | 07-03-2014 |
20150188877 | APN-BASED DNS QUERY RESOLUTION IN WIRELESS DATA NETWORKS - Systems and methods for APN-based DNS query resolution for wireless data networks are disclosed. Some implementations include receiving a domain name system (DNS) query for a domain name from a device having a source IP address, the DNS query being associated with an access point name, determining whether the source IP address is within a predetermined IP address range, upon determining the source IP address is within the predetermined IP address range, updating the DNS query to include an updated domain name unique to the predetermined IP address range, forwarding the updated DNS query to a DNS server for resolution, receiving an IP address corresponding to the updated DNS query from the DNS server, the IP address being different from an IP address associated with the DNS query, and providing the device with the IP address corresponding to the updated DNS query. | 07-02-2015 |
20150356534 | CONTENT PROVIDER CHARGED GATEWAY - Systems and methods for providing content provider charged web content to a mobile device are disclosed. A mobile routing server receives a request for a mobile device to access web content associated with a content provider. The mobile routing server determines whether the request is associated with a provider-charged gateway. If the request is associated with the provider-charged gateway, the mobile routing server provides access to the web content via the provider-charged gateway and signals a billing server to charge an account associated with the content provider for data charges associated with the access to the web content. If the request is not associated with the provider-charged gateway, the mobile routing server provides access to the web content via a regular Internet gateway and signals the billing server to charge an account associated with the mobile device for the data charges associated with the access to the web content. | 12-10-2015 |
Patent application number | Description | Published |
20090262779 | Multi-Core Fiber Grating Sensor - A twin core fiber for sensor applications is developed. It is particularly useful in de-coupling the strain and temperature and thus obtaining both measurement parameters at the same time and location. It is also particularly useful for measuring the temperature in a high humidity environment. The twin core fiber has two cores and each of the cores having a different dopant regime. Also, each of the cores includes a grating having substantially the same grating period. | 10-22-2009 |
20100067858 | Bandwidth-maintaining multimode optical fibers - The specification describes multimode optical fibers with specific design parameters, i.e., controlled refractive index design ratios and dimensions, which render the optical fibers largely immune to moderately severe bends. The modal structure in the optical fibers is also largely unaffected by bending, thus leaving the optical fiber bandwidth essentially unimpaired. Bend performance results were established by DMD measurements of fibers wound on mandrels vs. measurements of fibers with no severe bends. | 03-18-2010 |
20100148383 | Method of controlling longitudinal properties of optical fiber - A method of creating optical fiber to exhibit predetermined length-dependent characteristics (e.g., chromatic dispersion, polarization mode dispersion, cutoff wavelength, birefringence) includes the steps of: characterizing the fiber's selected characteristic(s) as a function of length; and performing a “treatment” which modifies the refractive index over the given length to adjust the defined parameter to fall within a defined tolerance window. These steps may be repeated one or more times until the measure of the parameter falls with the defined tolerance limits. The treatment process may include, for example, a low energy actinic radiation exposure, anneal, mechanical strain, DC voltage, plasma application, etc. Indeed, if the treatment process is repeated, a different technique may be used to adjust the refractive index (“different” processes include, for example, modifying the strength/time of a UV exposure, temperatures for annealing, etc.). | 06-17-2010 |
20100284659 | FILTER FIBER FOR USE IN RAMAN LASING APPLICATIONS AND TECHNIQUES FOR MANUFACTURING SAME - An optical waveguide has a refractive index variation that is structured to provide the fiber, over a wavelength operating range, with an effective area supporting multiple Stokes shifts and with a negative dispersion value at a target wavelength within the wavelength operating range. The refractive index variation is further structured to provide the fiber with a finite LP | 11-11-2010 |
20100287993 | Optical fiber manufacture - The specification describes methods for the manufacture of very large optical fiber preforms wherein the core material is produced by MCVD. Previous limitations on preform size inherent in having the MCVD starting tube as part of the preform process are eliminated by removing the MCVD starting tube material from the collapsed MCVD rod by etching or mechanical grinding. Doped overcladding tubes are used to provide the outer segments of the refractive index profile thus making most effective use of the MCVD produced glass and allowing the production of significantly larger MCVD preforms than previously possible. | 11-18-2010 |
20100290106 | Cascaded Raman Fiber Laser System Based on Filter Fiber - A light generation and amplification system includes a length of laser-active filter fiber having a refractive index profile that suppresses unwanted Stokes orders at wavelengths longer than a target wavelength and that has normal dispersion over its operating wavelength. A nested series of reflectors is provided at the fiber's input and output ends, and are configured to provide a nested series of Raman cavities, separated in wavelength by approximately the respective Stokes shifts. The first cavity in the series is a combined cavity that provides laser oscillation due to a combination of ionic gain and feedback at a selected first wavelength and that provides Raman gain to light at the first Stokes shift of the first wavelength when light at the first wavelength has an energy exceeding a Raman scattering threshold. The Raman cavities provide a stepwise transition between the first wavelength and the target wavelength. | 11-18-2010 |
20110129190 | Techniques for Manipulating Crosstalk in Multicore Fibers - A multicore optical fiber includes a plurality of core regions disposed within a common cladding region. Each of the plurality of core regions is configured, in combination with the common cladding region, to propagate light along a longitudinal axis of the fiber. At least two core regions are configured to inhibit resonant coupling of propagated light therebetween within a selected region of operation. At least one segment of the fiber includes a twist that is configured such that when the twisted segment is subjected to a bend having a selected radius, the twist creates a controlled change in the amount of crosstalk between the at least two core regions, compared with the amount of crosstalk between the at least two core regions when a bend having the selected radius is introduced into a non-twisted segment of the fiber. | 06-02-2011 |
20110243519 | OPTICAL FIBERS WITH TRUNCATED CORES - Optical fiber designs are depicted with a core having an alpha profile inner portion and a steep vertical step between the core and a cladding with no shoulder, referred to herein as a truncated core. A further aspect of this invention can include a trench between the truncated core and cladding. In this embodiment, the core performs as not only as the primary light guiding structure, but now also functions essentially the same as that of a trench structure. Thus, what was formally a trench can now be much less negative or even positive. | 10-06-2011 |
20110274398 | MULTICORE FIBERS AND ASSOCIATED STRUCTURES AND TECHNIQUES - A multicore fiber comprises a plurality of cores extending along the length of a fiber body. Each of the cores is surrounded by a cladding. The plurality of cores and surrounding cladding provide respective index variations, so as to form a respective plurality of waveguides for conducting parallel data transmissions from a first end of the fiber to a second end. The plurality of cores has a cross-sectional geometry in which the plurality of cores is configured in a polygonal array, in which at least some of the cores are positioned at the vertices of the array. The polygonal array is configured such that neighboring cores in the array are separated from each other by a distance that is sufficient to prevent crosstalk therebetween. | 11-10-2011 |
20110274435 | MULTICORE FIBER TRANSMISSION SYSTEMS AND METHODS - An optical data link includes first and second pluralities of transmission devices, at least one of which is configured as an array. A multichannel transmission link has a first end connected to the first plurality of transmission devices and a second end connected to the second plurality of transmission devices so as to form a plurality of parallel transmission channels therebetween. The multichannel transmission link includes a multicore fiber with a plurality of individual cores having a configuration matching the array configuration of the at least one plurality of transmission devices. The multicore fiber has an endface connected directly to the at least one plurality of transmission devices, with the individual cores of the multicore fiber aligned with respective devices in the at least one plurality of transmission devices. Further described are access networks and core networks incorporating a transmission link comprising at least one span of a multicore fiber. | 11-10-2011 |
20110279888 | MULTICORE TRANSMISSION AND AMPLIFIER FIBERS AND SCHEMES FOR LAUNCHING PUMP LIGHT TO AMPLIFIER CORES - An optical transmission and amplification system includes a multichannel transmission span with a length of a multicore transmission fiber having a plurality of individual transmission cores. A first tapered multicore coupler provides connectivity between the plurality of transmission cores of the multicore fiber and a respective plurality of individual transmission leads. A fiber amplifier is provided having a plurality of individual cores including at least one pump core and a plurality of amplifier core. A second tapered multicore coupler provides connectivity between the amplifier cores of the fiber amplifier and a respective plurality of amplifier leads, and between the at least one pump core and a respective pump lead. | 11-17-2011 |
20110280517 | TECHNIQUES AND DEVICES FOR LOW-LOSS, MODEFIELD MATCHED COUPLING TO A MULTICORE FIBER - Devices and techniques are described for connecting each of plurality of terminals to respective individual cores of a multicore fiber. Each of the plurality of terminals is provided with a respective length of a single-core fiber. The single-core fibers are configured to maintain modal properties that arc substantially the same, within a tolerance range, at the front and rear ends, as the single-core fiber is tapered. The single-core fibers are assembled together. The front end of the assembly is tapered to form a front cross-section in which the single-core fiber cores are arranged in a configuration matching that of the cores of the multicore fiber. | 11-17-2011 |
20130188949 | Techniques For Reducing Crosstalk In Multicore Fibers - An optical fiber has two or more core regions disposed within a common cladding region. Each of the core regions is configured to guide a respective light transmission comprising at least one optical mode along the length of the fiber. The cores are arranged within the common cladding region according to a core configuration that substantially prevents crosstalk between modes of neighboring cores in the fiber, in a deployment of the fiber in which cross-coupling between neighboring cores is affected by perturbations arising in the deployed fiber. | 07-25-2013 |
20140036351 | Pump-Combining Systems And Techniques For Multicore Fiber Transmissions - An optical fiber coupler connects transmission multicore optical fiber (TMCF) with an amplifier multicore optical fiber (AMCF) and a plurality of optical pump fibers. The coupler includes a plurality of signal cores extending between a multicore input endface and a coupler output endface, and a plurality of pump cores extending between a pump input and the coupler output endface. The multicore input endface is connectable to the TMCF, and the pump input is connectable to the optical pump fibers. Each pump core is paired with a corresponding signal core to form a core pair that is adiabatically tapered such that signal light carried by the signal core is combined with pump light carried by the pump core. The coupler output endface is connectable to the AMCF such that the combined light output of each core pair is provided as an input to a respective AMCF core. | 02-06-2014 |
20140119694 | Techniques and Devices for Low-Loss Coupling to a Multicore Fiber - An optical pedestal fiber is configured to be taperable to form a tapered fiber having a mode field diameter at the tapered end that differs from the mode field diameter at the untapered end in correspondence with the difference between the cladding diameter at the tapered end and the cladding diameter at the untapered end. A plurality of such pedestal fibers can be used to construct a tapered fiber bundle coupler that provides matching of both core pitch and mode field diameter between a plurality of input fibers and individual cores of a multicore fiber. Further, the tapered fiber bundle coupler can be constructed using a plurality of fibers, in which individual fibers are configured to have different effective refractive indices, thereby suppressing crosstalk therebetween. | 05-01-2014 |
20140270670 | Bandwidth-Maintaining Multimode Optical Fibers - The specification describes multimode optical fibers with specific design parameters, i.e., controlled refractive index design ratios and dimensions, which render the optical fibers largely immune to moderately severe bends. The modal structure in the optical fibers is also largely unaffected by bending, thus leaving the optical fiber bandwidth essentially unimpaired. Bend performance results were established by DMD measurements of fibers wound on mandrels vs. measurements of fibers with no severe bends. | 09-18-2014 |
20150077837 | Gain-Equalized Few-Mode Fiber Amplifier - A few-mode rare-earth-doped amplifier fiber has equalized gain for the supported signal transmission modes. The fiber has a raised-index core surrounded by a lower-index cladding region. The core has a radius a | 03-19-2015 |
20150192733 | FEW MODED FIBER DEVICE EMPLOYING MODE CONVERSION - A few-moded fiber device has several discrete sections of few-moded fibers that are separated by mode converters, with each mode converter accomplishing mode conversion between one or more pairs of modes. The mode conversions can be accomplished using a sequence, such as a periodic or cyclic sequence that would cause (1) a signal wave launched with any mode to assume every other mode for one or more times; (2) the number of times the signal remains in any modal state is substantially the same; and (3) the net signal gain or loss or group delay of the input signal is substantially the same regardless of the state of input mode. A laser few-mode amplifier is provided. An optical transmission system is also provided. | 07-09-2015 |
20150253499 | Broadband Multi-Mode Optical Fibers With Flat-Zone In Dopant Concentration Profile - Described is a design approach to fabricating broadband graded-index multimode fibers where the concentration profile of at least one dopant in the core region includes at least one flat-zone. Designs for use in CWDM applications are also disclosed. | 09-10-2015 |
20150338286 | GRATING-BASED SENSOR - An optical fiber-based sensor is described that is suitable for operation in a gas-rich environment. The sensor comprises a chamber into which are mounted one or more segments of optical fiber, into which are inscribed a plurality of sensor gratings. Each of the plurality of sensor gratings is configured to have the same wavelength shift over time in response to a change in gas diffusion, such that gas diffusion parameters are excluded in the determination of the respective amount of change in temperature, applied strain, and gas diffusion. Also described is a fiber, and techniques for making same, comprising of cores extend through a common cladding. The cores are doped so as to create, in conjunction with the cladding, a plurality of waveguides having the same wavelength shift over time is response to a change in gas diffusion, but different wavelength shifts in response to changes in other parameters. | 11-26-2015 |
20150364897 | Discrete Raman Amplifier - A discrete Raman amplifier comprises a Raman gain fiber, an input port into the Raman gain fiber for receiving optical signals to be Raman amplified, and an output port out of the Raman gain fiber for emitting Raman-amplified optical signals. A pump light input provides pump light to the Raman gain fiber at a plurality of wavelengths so as to provide Raman amplification over the selected signal wavelength range. Within both the pump light wavelength range and the selected signal wavelength range, the Raman gain fiber has only positive chromatic dispersion, and the Raman gain fiber has a moderate effective area. | 12-17-2015 |
Patent application number | Description | Published |
20100142789 | METHOD FOR CORRECTING MOTION ARTIFACTS IN MAGNETIC RESONANCE IMAGES - For resonance image data of an imaged subject, a method that first detects and estimates the dominant motions of k-space data (i.e., the motion vectors) and then constructs a graphical model for each estimated motion vector. The segments of the k-space that are determined to be corrupted by motion are restored by minimizing the energy associated with the corresponding graphical model. Consequently, the MR image of the imaged subject becomes free of motion artifacts. | 06-10-2010 |
20110064285 | SYSTEM AND METHOD FOR MULTI-IMAGE BASED STENT VISIBILITY ENHANCEMENT - A method for enhancing stent visibility in digital medical images includes providing a time series of 2-dimensional (2D) images of a stent in a vessel, estimating motion of the stent in a subset of images of the time series of images, estimating motion of clutter in the subset of images, where clutter comprises anatomical structures other than the stent, estimating a clutter layer in the subset of images from the estimated clutter motion, estimating a stent layer in the subset of images from the clutter layer and the estimated clutter motion, and minimizing a functional of the estimated stent motion, the estimated stent layer, the estimated clutter motion, and the estimated clutter layer to in calculate a refined stent layer image, where the refined stent layer image has enhanced visibility of the stent. | 03-17-2011 |
20110103674 | MARKER DETECTION IN X-RAY IMAGES - A method for detecting markers within X-ray images includes applying directional filters to a sequence of X-ray image frames. Marker candidate pixels are determined based on the output of the directional filters. Candidate pixels are grouped into clusters and distances between each possible pair of clusters is determined and the most frequently occurring distance is considered an estimated distance between markers. A first marker is detected at the cluster that most closely resembles a marker based on certain criteria and a second marker is then detected at a cluster that is the estimated distance from the first marker. The pair of first and second marker detections is scored to determine detection quality. If the detected marker pair has an acceptable score then the detected marker pair is used. | 05-05-2011 |
20120128226 | AUTOMATIC DETECTION OF CONTRAST INJECTION - A method for automatically detecting the presence of contrast in an x-ray image includes acquiring an x-ray image prior to administration of contrast. A background image is estimated based on the x-ray image. The contrast is administered. A set of x-ray images is acquired. The background image is subtracted from the set of images. Image intensity is determined for each of the subtracted images. The subtracted images having highest image intensity are selected. A predefined shape model is fitted to the selected subtracted images. The fitting of the predefined shape model is used to fit the shape model to each of the subtracted images. A feature value is calculated for each image frame based on pixel intensities of each pixel fitted to the shape model for the corresponding subtracted image. An image frame of peak contrast is determined by selecting the image frame with the greatest feature value. | 05-24-2012 |
20120134553 | Spatio-Temporal Analysis for Automatic Contrast Injection Detection on Angiography During Trans-Catheter Aortic Valve Implantation - A method that includes generating a contrast feature curve for a medical image sequence including a plurality of frames, where the contrast feature curve represents contrast feature values of the frames. The method further includes detecting a peak in the contrast feature curve, and determining whether the peak corresponds to at least one of contrast injection in an aortic root, contrast injection in a balloon, and a non-contrast injected region. | 05-31-2012 |
20140064326 | NOISE ROBUST TIME OF FLIGHT ESTIMATION FOR ACOUSTIC PYROMETRY - An acoustic signal traversing a hot gas is sampled at a source and a receiver and is represented in overlapping windows that maximize useable signal content. Samples in each window are processed to represented in different sparsified bins in the frequency domain. Determining a signal delay between the source and the receiver from a summation of maximum smoothed coherence transform cross-correlation values of different data windows wherein a sparseness of a mean smoothed coherence transform cross-correlation of windows is maximized. Determining a set of delay times wherein outliers are deleted to estimate a time of flight from which a temperature of the hot gas is calculated. | 03-06-2014 |
20140221832 | TUNING ULTRASOUND ACQUISITION PARAMETERS - Values for ultrasound acquisition parameters are altered in a manifold space. The number of parameters to be set is reduced using a manifold. Virtual parameters different than the acquisition parameters are used to alter the greater number of acquisition parameters. In a further use, optimum image settings may be obtained in an automated system by measuring image quality for feeding back to virtual parameter adjustment. | 08-07-2014 |
20150063411 | NON-INTRUSIVE MEASURMENT OF HOT GAS TEMPERATURE IN A GAS TURBINE ENGINE - A method and apparatus for operating a gas turbine engine including determining a temperature of a working gas at a predetermined axial location within the engine. An acoustic signal is encoded with a distinct signature defined by a set of predetermined frequencies transmitted as a non-broadband signal. Acoustic signals are transmitted from an acoustic transmitter located at a predetermined axial location along the flow path of the gas turbine engine. A received signal is compared to one or more transmitted signals to identify a similarity of the received signal to a transmitted signal to identify a transmission time for the received signal. A time-of-flight is determined for the signal and the time-of-flight for the signal is processed to determine a temperature in a region of the predetermined axial location. | 03-05-2015 |
Patent application number | Description | Published |
20080214453 | Methods for treating inflammation - The present invention provides a method for treating inflammation in a subject which comprises administering to the subject soluble receptor for advanced glycation endproduct (sRAGE) in an amount effective to inhibit binding of advanced glycation endproducts (AGEs) to RAGE thereby treating inflammation in the subject. The present invention also provides for a method for treating inflammation in a subject which comprises administering to the subject an agent in an amount effective to inhibit the interaction between receptor for advanced glycation endproduct (RAGE) and its ligand thereby treating inflammation in the subject. | 09-04-2008 |
20080260717 | Methods for Reducing Seizure-Induced Neuronal Damage - This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure. | 10-23-2008 |
20080274975 | Methods and Compositions for Inhibiting Abad/Abeta Protein Interaction - This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell. | 11-06-2008 |
20090060925 | Rage Fusion Proteins and Methods of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies. | 03-05-2009 |
20100136002 | METHODS FOR TREATING AND PREVENTING MULTIPLE SCLEROSIS - We have discovered that LRG-47 (also called p47 GTPase), plays a central role in the pathogenesis of multiple sclerosis, and that inhibition of LRG-47 activity by anti-LRG-47 antibodies or of LRG-47 expression by siRNA dramatically reduce the pathology and symptoms of multiple sclerosis. Certain embodiments of the invention are directed to the therapeutic use of anti-LRG-47 antibodies (mouse or rabbit or other antibodies that are humanized or human antibodies to LRG-47, preferably antibodies made against human LRG-47) or siRNA or antisense nucleotides that specifically hybridize with the gene or mRNA or cDNA encoding human LRG-47 to treat or prevent multiple sclerosis and other autoimmune diseases that are T-cell-mediated. Other embodiments are directed to methods for the diagnosis of multiple sclerosis or to determining the aggressiveness of multiple sclerosis by determining the amount of human LRG-47 or LRG-47 mRNA in a biological sample from the patient. | 06-03-2010 |
20100291074 | CYCLOPHILIN D-AMYLOID BETA INTERACTION POTENTIATES MITOCHONDRIAL DYSFUNCTION IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE - The present invention is directed to methods for treating or preventing Alzheimer's disease by administering therapeutically effective amounts of an agent that reduces Cyclophilin D expression in a patient, or that reduce Cyclophilin D activity or its ability to form a complex with Amyloid beta. Such agents include antisense nucleotides and small interfering RNAs, antibodies that selectively bind to Cyclophilin D, and cyclosporine A and D. | 11-18-2010 |
20110171194 | METHODS AND COMPOSITIONS FOR INHIBITING ABAD/ABeta PROTEIN INTERACTION - This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aβ protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell. | 07-14-2011 |