Wu, MD
Bei Wu, Frederick, MD US
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20100197070 | Methods and Apparatuses for Manufacturing Cast Silicon From Seed Crystals - Methods and apparatuses are provided for casting silicon for photovoltaic cells and other applications. With these methods, an ingot can be grown that is low in carbon and whose crystal growth is controlled to increase the cross-sectional area of seeded material during casting. | 08-05-2010 |
20110158887 | Apparatus and method of use for casting system with independent melting and solidification - This invention relates to a two or three-stage apparatus and method of use to produce high purity silicon, such as for use in solar panels and/or photovoltaics. The device of this invention includes a melting apparatus with a delivery device, a holding apparatus with a tipping or transfer mechanism, and at least one solidification apparatus for receiving a molten feedstock. The optimized designs of individual apparatuses function efficiently in combination to produce high purity silicon. | 06-30-2011 |
Binbin Wu, Odenton, MD US
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20110153547 | SYSTEM AND METHOD FOR SHAPE BASED RETRIEVAL OF PRIOR PATIENTS FOR AUTOMATION AND QUALITY CONTROL OF RADIATION THERAPY TREATMENT PLANS - A system and method for determining at least one new treatment plan for at least one new patient, comprising: providing at least one representation of the at least one new patient's at least one organ at risk relative to at least one target; searching for at least one prior treatment plan for at least one prior patient with at least one similar representation; and reviewing the at least one prior treatment plan for the at least one prior patient in order to determine whether the at least one new treatment plan can be improved based on information in the at least one prior treatment plan. | 06-23-2011 |
20140149335 | SYSTEM AND METHOD FOR SHAPE BASED RETRIEVAL OF PRIOR PATIENTS FOR AUTOMATION AND QUALITY CONTROL OF RADIATION THERAPY TREATMENT PLANS - A system and method for determining at least one new treatment plan for at least one new patient, comprising: providing at least one representation of the at least one new patient's at least one organ at risk relative to at least one target; searching for at least one prior treatment plan for at least one prior patient with at least one similar representation; and reviewing the at least one prior treatment plan for the at least one prior patient in order to determine whether the at least one new treatment plan can be improved based on information in the at least one prior treatment plan. | 05-29-2014 |
Chao-Cheng Wu, Baltimore, MD US
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20130136323 | METHOD OF DETECTING FOREIGN BODIES - A system for detecting post-operative retained foreign bodies has a data storage unit adapted to receive and store a reference image of a surgical object, and a data processor in communication with the data storage unit. The data processor is configured to receive an image of an internal region of a patient and to receive the reference image from the data storage unit, and the data processor is configured to perform operations based on an algorithm to compare the reference image to at least a portion of the image of the internal region of the patient and determine whether a retained foreign body is present in the patient. | 05-30-2013 |
Dong Ho Wu, Olney, MD US
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20090066952 | APPARATUS AND SYSTEM FOR ELECTRO MAGNETIC FIELD MEASUREMENTS AND AUTOMATIC ANALYSES OF PHASE MODULATED OPTICAL SIGNALS FROM ELECTROOPTIC DEVICES - An apparatus, for measuring an electric field while minimally perturbing the electric field being measured, includes an analyzing stage and a sensor head. The sensor head is optically coupled to the analyzing stage by a laser probe beam transmitted from the analyzing stage. The sensor head includes an electro optic crystal disposed between two gradient index lenses, where the first gradient index lens emits a laser beam transmitted from the analyzing stage to the sensor head, where the electric field is applied and where, the electro optic crystal transforms the laser beam probe into a phase modulated laser beam. The second gradient index lens transmits the phase modulated laser beam back to the analyzing stage, where polarization optics and a photodetector convert the phase modulated laser beam into an electrical signal representing field strength and phase of the electric field. | 03-12-2009 |
20100264904 | APPARATUS AND SYSTEM FOR A QUASI LONGITUDINAL MODE ELECTRO OPTIC SENSOR FOR HIGH POWER MICROWAVE TESTING - An apparatus, for measuring an applied electrical field and for reducing perturbation to the electrical field being measured, includes a laser integrated into an electro optic crystal sensor head prior to the output fiber. A probe beam is passed along the crystal direction of low birefringence of nearly circular optical indicatrix, rather than one of high EO modulation. The EO crystal is placed between two crossed polarizers and oriented such that a small tilt angle is subtended between its optic axis and the path of the probe beam. Improved optical coupling is achieved by using a large core multimode fiber at the output, to reduce optical insertion losses. A collimating lens emits the intensity modulated laser beam back to a photodetector, where the intensity modulated laser beam is converted to an electrical signal representing both field strength and phase of the electrical field applied to the sensor head. | 10-21-2010 |
20100290487 | RECYCLING PUMP-BEAM METHOD AND SYSTEM FOR A HIGH-POWER TERAHERTZ PARAMETRIC SOURCE - A method and a system are implemented in the fabrication of a portable high power terahertz beam source that can produce a tunable, high power terahertz beam over the frequency from 0.1 THz to 2.5 THz. The terahertz source employs a recycling pump beam method and a beam quality control device. The beam quality control device may or may not be required for a high power terahertz beam generation. In exemplary embodiments, a lithium niobate (LiNbO | 11-18-2010 |
20120024044 | SYSTEMS AND METHODS FOR DETECTING CONCEALED NUCLEAR MATERIAL - Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of the concealed nuclear material is detected, for each of the one or more locations, based on a characteristic of the measured ionized air density indicative of concealed nuclear materials. | 02-02-2012 |
20120305773 | METHODS AND SYSTEMS FOR REMOTELY DETECTING HAZARDOUS MATERIALS USING ELECTROMAGNETIC ENERGY - Systems and methods for remotely detecting nuclear and non-nuclear materials such as chemical agents and gas-phase explosives are disclosed. Nuclear and non-nuclear materials may be detected by transmitting electromagnetic energy toward a remote target area, collecting scattered electromagnetic energy reflected from the remote target area, analyzing an absorption spectrum of the collected scattered electromagnetic energy, and detecting a presence of at least one nuclear or non-nuclear material in the remote target area based on the analyzed absorption spectrum. | 12-06-2012 |
20130038324 | APPARATUS METHOD AND SYSTEM OF AN ULTRA SENSITIVITY OPTICAL FIBER MAGNETO OPTIC FIELD SENSOR - An apparatus and system, capable of measuring the magnitude and direction of magnetic fields including an ultra-sensitive, wideband magneto optic (MO) sensor having magneto-optic crystals is disclosed herein. The sensor exploits the Faraday Effect and is based on a polarimetric technique. An ultra sensitivity optical-fiber magneto-optic field sensor measures a magnetic field with minimal perturbation to the field, and the sensor can be used for High-power microwave (HPM) test and evaluation; Diagnosis of radar and RF/microwave devices; Detection/measurement of weak magnetic fields (e.g., magnetic resonance imaging); Characterization of very intense magnetic fields (>100 Tesla, for example rail gun characterization); Detection of very low-frequency magnetic fields; Characterization of a magnetic field over an ultra broad frequency band (DC—2 GHz); Submarine detection; and Submarine underwater communication. | 02-14-2013 |
20150325324 | HIGH POWER, BROADBAND TERAHERTZ, PHOTOCONDUCTIVE ANTENNAS WITH CHAOTIC SHAPE ELECTRODES - A photoconductive antenna is described that includes a substrate that includes a pair of trenches. Furthermore, a pair of non-parallel electrodes, which can be designed with a chaotic electrode geometry, can each be deposited in one of the trenches, and can be configured to produce chaotic trajectories of incoherent electric currents. Finally, an insulation layer, which can be either a physical electrical insulation layer or an air gap, can be included between each of the pair of non-parallel electrodes and the trench walls. Overall, the thickness of the substrate, the thickness of the trenches, and the thickness of the non-parallel electrodes can each be optimized to produce a coherent terahertz beam. | 11-12-2015 |
20150338354 | Remote Detection and Identification of Nuclear Materials Using Multiple Ion-Chambers - A system and method for detecting and identifying nuclear materials by detecting and measuring positive and negative ions in multiple ion chambers, wherein each ion chamber comprises a different gas, including oxygen, argon, nitrogen, carbon dioxide, and humid air, and one or more ion counters. The ion data can be transmitted to an isotope identification module. The ion data can include a distinctive pattern data of positive-ion production rates and negative-ion production rates generated from the measured positive and negative ions. The isotope identification module can compare the pattern data of positive-ion production rates and negative-ion production rates to an isotope data library, and identify a detected nuclear isotope with the isotope identification module. A display can show the identified detected nuclear isotope; a probability of the presence of the detected nuclear isotope; and a radioactivity of the detected nuclear isotope. | 11-26-2015 |
Florence Wu, Gaithersburg, MD US
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20090068741 | Methods and Compositions for Improving the Health of Cells in Culture - The invention relates generally to improving the growth properties of cells in culture and more specifically to accumulating beneficial mutations in the genome of cells growing in culture. Methods are disclosed for isolating cells with improved growth properties for a number of different adverse cell culture conditions which develop during prolonged culture of cells. | 03-12-2009 |
Fu-Yuarn Wu, Bethesda, MD US
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20140315664 | Compact Basketball Return Device Designed for Made Shots - A basketball return device that surrounds the net, restricting most made shots to fall beneath the front half of the rim. The back half of the cylinder interior is hard, while the interior of the front half is lined with a cushioning material. Suspended from the cylinder piece so that it is directly below the front half of the cylinder is a ricocheter, a half cone that deflects the basketball forward. In the normal position, the hard side faces the backboard and the device should be able to handle all normal shots except those from or near the sides. To better handle side shots, the movable part of the device should be rotated 90 degrees. The device can be raised and attached to the rim unit by using a rod-like instrument. | 10-23-2014 |
Guanli Wu, Eldersburg, MD US
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20100254904 | Novel therapeutic delivery systems - Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. | 10-07-2010 |
Haitao Wu, Rockville, MD US
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20080233047 | Symmetric and Asymmetric Halogen-Containing Metallocarboranylporphyrins and Uses Thereof - The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. | 09-25-2008 |
20080279781 | Glycosylated Carboranylporphyrins and Uses Thereof - The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity glycosylated carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, and head and neck. The invention is also directed to using these glycosylated carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. | 11-13-2008 |
Hao Fang Wu, Chevy Chase, MD US
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20120166208 | AUTOMATED CLUSTERING FOR PATIENT DISPOSITION - The described concepts relate to automated patient disposition. One example can receive a clinician's disposition for a patient. This implementation can perform parameter-based cluster analysis on the patient and a set of patients to identify a sub-set of the patients with which the patient has a high similarity. This example can also cause a graphical user interface to be generated that conveys parameters from the sub-set of the patients and the patient. | 06-28-2012 |
Herren Wu, Gaithersburg, MD US
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20120034212 | Human Anti-IL-6 Antibodies With Extended In Vivo Half-Life And Their Use In Treatment Of Oncology, Autoimmune Diseases And Inflammatory Diseases - The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors. | 02-09-2012 |
20120134984 | MOLECULES WITH EXTENDED HALF-LIVES AND USES THEREOF - The invention is directed to a molecule comprising an albumin binding domain (ABD) and an FcRn binding moiety, wherein said molecule has enhanced pharmacologic properties in vivo. | 05-31-2012 |
20130231463 | Cell Display Of Antibody Libraries - The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of screening the libraries for antibodies or antibody fragments with desired characteristics. | 09-05-2013 |
20130273071 | Recombinant IL-9 Antibodies And Uses Thereof - The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide. | 10-17-2013 |
20130280251 | Stabilized Angiopoietin-2 Antibodies And Uses Thereof - Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided. | 10-24-2013 |
20130295098 | MULTISPECIFIC EPITOPE BINDING PROTEINS AND USES THEREOF - The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases. | 11-07-2013 |
20140141994 | Protein Scaffolds - The invention provides protein scaffolds and methods of preparing, screening, engineering and using such protein scaffolds. | 05-22-2014 |
20140170142 | Molecules With Extended Half-Lives And Uses Thereof - The invention is directed to a molecule comprising an albumin binding domain (ABD) and an FcRn binding moiety, wherein said molecule has enhanced pharmacologic properties in vivo. | 06-19-2014 |
20140171623 | Modulation Of Antibody Effector Function By Hinge Domain Engineering - The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or C1q. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes. | 06-19-2014 |
20140302058 | HUMAN ANTI IL-6 ANTIBODIES WITH EXTENDED IN VIVO HALF-LIFE AND THEIR USE IN TREATMENT OF ONCOLOGY, AUTOIMMUNE DISEASES AND INFLAMMATORY DISEASES - The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors. | 10-09-2014 |
Hsuan-Chen Wu, Greenbelt, MD US
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20110195860 | FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAME - Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis. | 08-11-2011 |
Iwen Wu, Baltimore, MD US
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20120189588 | Compositions and Methods for Implantation of Processed Adipose Tissue and Processed Adipose Tissue Products - The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue. | 07-26-2012 |
Jianqing Wu, Beltsvile, MD US
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20130283398 | Versatile Log System - A versatile log system is disclosed for producing logs for documents or other objects. The system allows authorized users to configure a log table and at least one coupled table, validate log entries for the log table, and validate data records for the coupled table. When the system is installed with investigative identity data search algorithm, identity data processing algorithm, interactive data entry features, and phrase construction feature, it can significantly improve production efficiency and data accuracy. | 10-24-2013 |
Jianqing Wu, Hyattsville, MD US
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20150317153 | Online Computing System - An online computing system hosting a plurality of computing projects in the form of database records allows users to search computing projects by search keys, project ID or category names, conduct computation for found projects, and create new computing projects at client computers. Each computing job is performed by searching the database, selecting a computing project by clicking on one of the found links on the search result page, and providing data in a computing data input form for submission. A large number of computing projects can be created by a plurality of users on client computers. | 11-05-2015 |
Jianqing Wu, Beltsville, MD US
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20130013996 | Method for Improving Document Review Performance - The present invention is a method for accurately coding documents. The method, if used by experienced and motivated document reviewers, has the potential to dramatically improve adjusted review consistency, reduce coding errors, and produce the best review product. The method will also result in useful case history files, which are useful to litigation attorneys in every phrase of litigation including motion argument, merit trial, appeal, and future litigation. | 01-10-2013 |
20130198521 | Secure File Drawer and Safe - An online file storage system having secure file drawer and safe is disclosed for securely storing and sharing confidential files. The system comprises a web-based user interface, tools for setting up server-side encryption method and client-side encryption method, tools for synchronizing encryption between different computers, tools for uploading files, tools for tracking files, tools for granting the right of access to files to the owner of other safes, and tools for generating authenticity certificate for proving the upload time and the substance of the files in a future time. | 08-01-2013 |
20130346622 | Online computing system - An online computing system hosting a plurality of computing projects in the form of database records allows users to search computing projects by search keys, project ID or category names, conduct computation for found projects, and create new computing projects at client computer; and each computing job was done by searching the database, selecting a computing project by clicking on one of the found links on the search result page, and providing data in a computing data input form for submission. | 12-26-2013 |
20140012922 | Web-based Information Management System - A web-based information management system allows a group of users to collect, validate, and share data of unknown types and volume in real time over the Internet. The project work environment for a group can be created, modified, and reset instantly during any project life and between project life cycles by a plurality of methods without effecting system integrity and core functions such as data validation, searches and sorting, data preservation, data display feature, and productive data entry methods. | 01-09-2014 |
20140222780 | Investigative Identity Data Search Algorithm - An identity search algorithm for identifying a plurality of all identity data such as personal names and entity names that might exist in a table or file containing a large number of identity data in the investigative environment. The algorithm is intended to identify person and entities in the shortest time possible with an overly inclusive results. The core algorithm is used in an environment with a growing number of names in the name table, and implemented with a web-based user interface, it can dramatically improve the identity-searching efficiency and increase the chance to generate useful leads in typical discovery and investigation. | 08-07-2014 |
20140317147 | Method for Improving Document Review Performance - The present invention is a method and process for accurately and efficiently coding documents in electronic discovery. The method, if used by highly experienced and motivated document reviewers in a collegial and harmonic environment, has the potential to increase adjusted review consistency, reduce coding errors, eliminate duplicate efforts, increase review speed, decrease the risks of exposure, and dramatically improve review performance. The method will also result in useful case history files, which are useful in every phrase of litigation, including motion argument, merit trial, appeal, and future litigation. | 10-23-2014 |
20140358518 | Translation Protocol for Large Discovery Projects - The present invention is a server-based protocol for improving translation performance for cases where a large number of documents are generated in a source language context but their controversies are adjudicated in a different language context. The protocol is intended to improve terminology consistency, offset the effects of contextual shift on perceived facts in translations, and improve task-tracking order. If the protocol is used by well trained and motivated document reviewers in a collaborative and harmonic environment, it can reduce unnecessary translations, improve translation accuracy and legibility, minimize the needs for amendments, control translation costs, and help the client significantly improve its litigation position. | 12-04-2014 |
20160094681 | Versatile Information Management System - A versatile information management system allows users to configure web page configuration, navigation system, database tables, personal searchable pads, and can be configured as a static web site, a dynamic web site, a versatile data entry system, a real-time information sharing system, a training and leaning system, an investigative discovery system, and versatile electronic binder. The system is implemented with global editing capability, unique data validating scheme, archival method, interactive search and data-feeding function, standard sorting method, local and global search features, and phrase constructing function. | 03-31-2016 |
Jianwei Wu, Potomac, MD US
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20140113921 | FORMULATIONS OF PYRIMIDINEDIONE DERIVATIVE COMPOUNDS - The present disclosure relates to pharmaceutical compositions of pyrimidinedione derivative compounds and methods of preparing and uses thereof. The disclosure also relates to methods of enhancing bioavailability of pyrimidinedione derivative compounds in pharmaceutical compositions administered to a subject and methods of reducing the amount of a pyrimidinedione derivative compound in a pharmaceutical composition while achieving the same bioavailability in a subject. | 04-24-2014 |
Jian-Young Wu, Gaithersburg, MD US
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20110021885 | SUBDURAL ELECTRO-OPTICAL SENSOR - A subdural electro-optical sensor system may include a substrate to which is attached an array of electrodes, light emitters, and light detectors. The sensor system may be sufficiently thin, flexible, sterile and biocompatible to be positioned subdurally. | 01-27-2011 |
Jin Chu Wu, Frederick, MD US
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20130070977 | STANDARD CALIBRATION TARGET FOR CONTACTLESS FINGERPRINT SCANNERS - A contactless, three-dimensional fingerprint scanner apparatus, method, and system are described. The contactless fingerprint scanner can provide either, or both, topographical contrast of three-dimensional fingerprint features and optical contrast of a three-dimensional fingerprint surface. Data captured from scanning of a target with known geometric features mimicking fingerprint features can be examined as images or surface plots and analyzed for fidelity against the known target feature specifications to evaluate or validate device capture performance as well as interoperability. The target can be used by scanner vendors and designers to validate their devices, as well as to perform type certification. | 03-21-2013 |
Julie Adams Wu, Columbia, MD US
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20100221237 | ENZYME DISRUPTION OF BACTERIAL BIOFILMS - Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied. | 09-02-2010 |
June Wu, North Potomac, MD US
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20150029660 | CONFIGURABLE HEAT CONDUCTING PATH FOR PORTABLE ELECTRONIC DEVICE - A portable electronic device includes at least one energy module which further included thermoelectric materials which may convert heat to electric power. A plurality of heat removers selectively thermal contact to at least one wall of an enclosure of the portable electronic device depended on the configuration of the portable electronic device. | 01-29-2015 |
20150029661 | WEARABLE PORTABLE ELECTRONIC DEVICE WITH HEAT CONDUCTING PATH - A wearable portable electronic device includes at least one energy module which further included thermoelectric materials which may convert heat to electric power. A plurality of heat spreader thermally and electronically contact to at least one wall of an enclosure of the wearable portable electronic device by using graphene layer. | 01-29-2015 |
Katherine Wu, Bel Air, MD US
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20140122048 | System and method for personalized cardiac arrhythmia risk assessment by simulating arrhythmia inducibility - A method of determining a likelihood of an occurrence of a cardiac arrhythmia in a patient includes receiving three-dimensional imaging data of said patient's heart, constructing a whole-heart model for simulating at least one of electrophysiological activity or electromechanical activity of the patient's heart using the three-dimensional imaging data, simulating a response of the patient's heart to each of a plurality of stimulations to a corresponding plurality of different locations within the patient's heart using the whole-heart model, classifying each simulation outcome for each stimulation as one of a normal heart rhythm or a cardiac arrhythmia, calculating a likelihood index based on results of the classifying, and determining the likelihood of the occurrence of the cardiac arrhythmia in the patient based on the likelihood index. Software and data processing systems that implement the above methods are also provided. | 05-01-2014 |
Lan Wu, Bethesda, MD US
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20090214588 | Vaccines against aids comprising cmv/r-nucleic acid constructs - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-27-2009 |
20110200636 | METHOD FOR IMPROVING THE BREADTH OF THE IMMUNE RESPONSE TO DIVERSE STRAINS AND CLADES OF HIV - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-18-2011 |
Lini Wu, Boyds, MD US
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20120303472 | METHODS FOR PLACING, ACCEPTING, AND FILLING ORDERS FOR PRODUCTS AND SERVICES - Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer. | 11-29-2012 |
Peggy Wu, Ellicott City, MD US
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20140372362 | SYSTEMS AND METHODS FOR DETERMINING SOCIAL PERCEPTION SCORES - A system for evaluating communicative acts to determine a social perception network based on communicative acts between a plurality of communicative pairs. Each communicative pair includes two communicating entities. The system includes a patterns database, a scoring processor, and a communications network aggregation processor. The patterns database stores behavior recognition patterns defining particular behaviors and a score associated with each of the particular behaviors. The scoring processor is configured to determine a pairwise social perception score for the communicative pair based on the particular behaviors identified in the communicative acts. The scoring processor is configured to determine a different pairwise social perception score for each one of the plurality of communicative pairs. The communications network aggregation processor is configured to combine the pairwise social perception scores for each of the plurality of communicative pairs into a social perception network. Other embodiments including other systems, methods, and products are also disclosed. | 12-18-2014 |
20150339336 | SYSTEMS AND METHODS FOR DETERMINING SOCIAL PERCEPTION - A system for evaluating communicative acts between communicative pairs to determine a social perception network representation. Each communicative pair includes two entities participating in a communicative act. The system includes a patterns database storing behavior recognition patterns defining particular behaviors that may be used in the communicative acts and a social perception score associated with each of the particular behaviors. The scoring processor determines a first pairwise social perception score for each communicative pair based on the particular behaviors in the communicative acts occurring during a first time frame. The scoring processor determines a different first pairwise social perception score for each of the communicative pairs during a first time frame and determines a different second social perception score for each of the communicative pairs during a second time frame. The communications network aggregation processor combines the pairwise social perception scores into a first social perception network representation. | 11-26-2015 |
20150379401 | SYSTEMS AND METHODS FOR DETERMINING SOCIAL PERCEPTION - A system for evaluating communicative acts to determine a social network perception representation based on communicative acts between a plurality of communicative pairs where each communicative pair includes a first group and an individual or a second group participating in corresponding communicative acts. The system includes a patterns database, a scoring processor, and a communications network aggregation processor. The patterns database stores behavior recognition patterns defining particular behaviors and a score associated with each of the particular behaviors. The scoring processor is configured to determine a pairwise social perception score for each of the communicative pairs based on the particular behaviors identified in the communicative acts. The scoring processor is configured to determine a different pairwise social perception score for each of the communicative pairs. The communications network aggregation processor combines the pairwise social perception scores for each of the plurality of communicative pairs into a social perception network representation. | 12-31-2015 |
20150379402 | SYSTEMS AND METHODS FOR DETERMINING SOCIAL PERCEPTION - A system for evaluating communicative acts, between a plurality of communicative pairs, to determine a social network perception representation. Each communicative pair includes two entities participating in a corresponding one or more of the communicative acts. The system includes a patterns database, a scoring processor, and a communications network aggregation processor. The patterns database stores behavior recognition patterns defining particular behaviors that may be used in the communicative acts and a social perception score associated with each of the particular behaviors. The communicative acts include non-verbal communicative acts. The scoring processor is configured to determine a pairwise social perception score for each communicative pair based on the particular behaviors identified in the communicative acts. The scoring processor is configured to determine a different pairwise social perception score for each of the communicative pairs. The communications network aggregation processor combines the pairwise social perception scores into a social perception network representation. | 12-31-2015 |
Pei-Hsun Wu, Towson, MD US
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20130071003 | SYSTEM AND DEVICE FOR CHARACTERIZING CELLS - A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis. | 03-21-2013 |
20150093779 | SYSTEM AND DEVICE FOR CHARACTERIZING CELLS - A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis. | 04-02-2015 |
Robert Wu, Gaithersburg, MD US
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20160113209 | SHEARING TOOL - A method for operating a shearing tool that includes: operating a first switch to control a drive unit to drive a blade of a blade set; and operating a second switch to cause the drive unit to operate in an anti-binding mode in which a direction of an input to the drive unit is alternated at least twice. A shearing tool is also provided. | 04-28-2016 |
Shanlu Wu, Rockville, MD US
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20130097275 | CLOUD-BASED STORAGE DEPROVISIONING - A device creates a first cloud storage container in a first region of cloud storage, clears a delete flag associated with the first cloud storage container, and stores a first data object in the first cloud storage container in the first region of cloud storage. The device receives a request to delete the first cloud storage container, sets a delete flag associated with the first cloud storage container based on the request to delete the first cloud storage container, and deletes the first cloud storage container if the request to delete has not been rescinded prior to expiration of a time period. | 04-18-2013 |
Shaoguang Wu, Lutherville, MD US
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20120027799 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY BOWEL DISEASE AND COLON CANCER - The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease). | 02-02-2012 |
Shuenn-Jue Wu, Rockville, MD US
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20110306036 | RT-LAMP assay for the detection of pan-serotype dengue virus - The invention relates to a reverse transcription loop-mediated isothermal amplification (LAMP) assay for the detection of dengue virus. The assay is capable of simultaneous detection of dengue 1-4 serotypes in a single reaction. | 12-15-2011 |
Stewart T. Wu, Glen Burnie, MD US
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20130308663 | APPARATUS AND METHOD TO ENABLE PRECISION AND FAST LASER FREQUENCY TUNING - An apparatus and method is provided to enable precision and fast laser frequency tuning. For instance, a fast tunable slave laser may be dynamically offset-locked to a reference laser line using an optical phase-locked loop. The slave laser is heterodyned against a reference laser line to generate a beatnote that is subsequently frequency divided. The phase difference between the divided beatnote and a reference signal may be detected to generate an error signal proportional to the phase difference. The error signal is converted into appropriate feedback signals to phase lock the divided beatnote to the reference signal. The slave laser frequency target may be rapidly changed based on a combination of a dynamically changing frequency of the reference signal, the frequency dividing factor, and an effective polarity of the error signal. Feed-forward signals may be generated to accelerate the slave laser frequency switching through laser tuning ports. | 11-21-2013 |
T.c. Wu, Stevenson, MD US
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20090110702 | Mesothelin Vaccines and Model Systems and Control of Tumors - Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line. | 04-30-2009 |
20150231239 | COMPOSITIONS AND METHODS FOR RENDERING TUMOR CELLS SUSCEPTIBLE TO CD8+ T CELL-MEDIATED KILLING - The present invention provides an immunoconjugate having the formula: T-c-E | 08-20-2015 |
Wai-Hong Wu, Ellicott City, MD US
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20120058466 | DIFFERENTIAL IMMUNOASSAY FOR PRRS VACCINE ANTIBODY - The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA). | 03-08-2012 |
Weimin Wu, Boyds, MD US
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20110060579 | Ultrasound Simulation Apparatus and Method - A method includes receiving data values associated with one of a position and orientation of a simulated scanner relative to an object. Image values are calculated, substantially in realtime, based on the data values. A simulated ultrasound image is rendered in a graphical display based on the image values. The simulated ultrasound image is representative of an interior or a simulated interior of the object on the ultrasound scan plane. Ultrasound simulation systems are also disclosed. | 03-10-2011 |
Wen-Li Wu, Gaithersburg, MD US
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20100315627 | Apparatus and Method for Enhancing the Electromagnetic Signal of a Sample - The present invention is an apparatus and method for enhancing the electromagnetic signal of a sample for ellipsometry which uses at least one auxiliary layer and at least one substrate layer. | 12-16-2010 |
Wen-Li Wu, Rockville, MD US
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20120172485 | DENTAL COMPOSITIONS WITH TITANIUM DIOXIDE NANOPARTICLES - A polymeric composition comprising modified-TiO | 07-05-2012 |
Xiaolin Wu, Gaithersburg, MD US
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20090088331 | INFLUENZA VIRUS NUCLEIC ACID MICROARRAY AND METHOD OF USE - The present invention relates generally to methods of detecting and identifying known and unknown viruses using hybridization microarrays to essentially all known influenza virus nucleotide sequences of at least one type that infect at least one species, the sequencing of nucleotides which hybridize to the microarrays and analysis of the hybridized sequences with existing databases, thus identifying existing or new subtypes of viruses. The present invention also relates to methods of use of the microarrays of the invention for the detection of influenza viruses, including variant influenza viruses. The method includes the use of a non-specific PCR amplification method to amplify sample nucleic acids. | 04-02-2009 |
Xiaoming Wu, North Potomac, MD US
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20130315346 | METHOD AND APPARATUS FOR PARALLEL DEMODULATION OF HIGH SYMBOL RATE DATA STREAMS IN A COMMUNICATIONS SYSTEM - A dynamic and flexible architecture and methods for demodulation of high data-rate streams with high symbol-rates, such as in satellite communications systems or computer network communications systems, is provided. A data stream of a data transmission is received, the data stream corresponding to a plurality of data symbols. A plurality of data samples corresponding to each of the data symbols is generated. Further, one or more representative data samples, corresponding each of the data symbols, are generated based at least in part on timing control signals and the generated data samples for the respective data symbol. The generated data samples corresponding to each of the data symbols other than the representative data samples are dropped. The timing control signals are then adjusted based at least in part on the generated representative data samples. | 11-28-2013 |
Xingjia Wu, Germantown, MD US
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20130103123 | Light-Emitting Devices for Wound Healing - Methods and devices related to wound healing using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring System 1, Ring System 2, Ring System 3, Ring System 4 or Ring System 5. | 04-25-2013 |
Xinyan Wu, Cockeysville, MD US
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20100285031 | Hox Compositions and Methods - The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject. | 11-11-2010 |
20130333059 | HOX COMPOSITIONS AND METHODS - The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject. | 12-12-2013 |
Xueling Wu, Potomac, MD US
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20120237523 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes. | 09-20-2012 |
20120244166 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and uses of these antibodies, are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes. | 09-27-2012 |
20120282264 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes. | 11-08-2012 |
20130251726 | NOVEL HIV -1 BROADLY NEUTRALIZING ANTIBODIES - The present application relates novel HIV-1 broadly neutralizing antibodies. The antibodies of the present invention are further characterized by their ability to bind epitopes from the Env proteins. The invention also provides light and heavy chain variable region sequences. Compositions for prophylaxis, diagnosis and treatment of HIV infection are provided. | 09-26-2013 |
20140322163 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed. | 10-30-2014 |
20140350113 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF - Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556. | 11-27-2014 |
20150044137 | NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE - Neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed. | 02-12-2015 |
Xueling Wu, Bethesda, MD US
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20140205607 | FOCUSED EVOLUTION OF HIV-1 NEUTRALIZING ANTIBODIES REVEALED BY CRYSTAL STRUCTURES AND DEEP SEQUENCING - Antibody VRC01 represents a human immunoglobulin that neutralizes—˜90% of diverse HIV-1 isolates. To understand how such broadly neutralizing HIV-1 antibodies develop and recognize the viral envelope, we used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding of different antibodies to the same CD4-binding-site epitope. Antibody recognition was achieved through the evolution of complementary contact domains that were generated in diverse ways. Phylogenetic analysis of expressed heavy and light chains determined by deep sequencing revealed a common pathway of antibody heavy chain maturation confined to IGHV1-2*02 lineage that could pair with different light chains. The maturation pathway inferred by antibodyomics reveals that diverse antibodies evolve to a highly affinity-matured state to recognize an invariant viral structure, providing insight into the development and evolution of broadly neutralizing HIV-1 immunity. | 07-24-2014 |
Yicong Wu, Bethesda, MD US
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20140126046 | OPTOMECHANICAL MODULE FOR CONVERTING A MICROSCOPE TO PROVIDE SELECTIVE PLANE ILLUMINATION MICROSCOPY - A module for engagement with a conventional microscope to provide selective plane illumination microscopy is disclosed. The module is coupled to the translational base of the microscope and defines a mounting having a mount body in which an excitation objective having a first longitudinal axis is engaged to one portion of the mount body and a detection objective having a second longitudinal axis is engaged to another portion of the mount body such that the first longitudinal axis is in perpendicular geometric relation with the second longitudinal axis. | 05-08-2014 |
Yimin Wu, Frederick, MD US
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20090047303 | Method for improving the immunogenicity of plasmodium antigens - The present invention provides a Malaria antigen-carrier conjugate, which comprises a carrier protein and a plurality of | 02-19-2009 |
20100183678 | CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES - Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against | 07-22-2010 |
20130129777 | CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES - Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against | 05-23-2013 |
20150050314 | CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES - Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against | 02-19-2015 |
Yiming Wu, Greenbelt, MD US
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20120273158 | THERMOELASTIC COOLING - A cooling system based on thermoelastic effect is provided. The system comprises a heat sink, a refrigerated space and a regenerator coupled to the refrigerated space and to the heat sink to pump heat from the refrigerated space to the heat sink. The regenerator comprises solid thermoelastic refrigerant materials capable of absorbing or releasing heat. | 11-01-2012 |
Yin Wu, Silver Spring, MD US
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20110119218 | SYSTEM AND METHOD FOR DETERMINING AN ENTITY'S IDENTITY AND ASSESSING RISKS RELATED THERETO - The invention describes systems and methods of determining an entity's identity and assessing risk related to the entity's identity using a computer. A computer-based system including a tracking module, an information module, a risk assessment module, and a memory is provided. The tracking module records encounters of the entity with the computer-based system. The information module gathers and detects changes in biographic information and biometric information relating to the entity's identity. The risk assessment module evaluates risks associated with the entity. The memory stores the information. | 05-19-2011 |
Yingyun Wu, Rockville, MD US
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20080233150 | RESPIRATORY SYNCYTIAL VIRUS-VIRUS LIKE PARTICLE (VLPS) - The present invention discloses and claims virus like particles (VLPs) that express and/or contains RSV proteins. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing immunity to infections, including RSV. | 09-25-2008 |
20130122032 | RECOMBINANT NANOPARTICLE RSV F VACCINE FOR RESPIRATORY SYNCYTIAL VIRUS - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 05-16-2013 |
Yingyun Wu, Clarksburg, MD US
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20130039938 | HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS - This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs. | 02-14-2013 |
20150307849 | HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS - This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs. | 10-29-2015 |
Yingyun Wu, Gaithersburg, MD US
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20100239617 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 09-23-2010 |
20140294879 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 10-02-2014 |
20150265698 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 09-24-2015 |
20150266930 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 09-24-2015 |
20150306207 | RECOMBINANT NANOPARTICLE RSV F VACCINE FOR RESPIRATORY SYNCYTIAL VIRUS - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 10-29-2015 |
20150335730 | RECOMBINANT NANOPARTICLE RSV F VACCINE FOR RESPIRATORY SYNCYTIAL VIRUS - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 11-26-2015 |
20150359872 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 12-17-2015 |
Zhi-Liang Wu, North Potomac, MD US
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20140315992 | Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism - Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided. | 10-23-2014 |
Zhong Wu, Poolesville, MD US
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20150232926 | GENE EXPRESSION SIGNATURE FOR IL-6/STAT3 SIGNALING PATHWAY AND USE THEREOF - The present invention relates to a set of biomarkers, microarrays that provide for detection thereof, an expression signature comprising 16 genes or a subset thereof, and the use thereof in determining the regulation status of IL-6/STAT3 signaling pathway in a cell sample or subject, as well as compositions for the detection thereof. The regulation status of IL-6/STAT3 signaling pathway in a cell sample or subject may be assayed based on the level of expression of one or more of these genes. The methods and compositions provided herein may be used to evaluate IL-6/STAT3 pathway regulation status in a sample; classify a cell sample as having a deregulated or regulated IL-6/STAT3 signaling pathway; determine whether an agent modulates the IL-6/STAT3 signaling pathway; predict the response of a subject to an agent that modulates the IL-6/STAT3 signaling pathway; assign treatment to a subject; and/or evaluate the pharmacodynamic effects of therapies designed to regulate IL-6/STAT3 pathway signaling. Expression of the biomarkers is preferably determined by RT-PCR using SYBR Green methods, and the expression data analyzed and compared to a control sample by use of the random forest method. | 08-20-2015 |
Zhong Wu, Frederick, MD US
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20120252689 | GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY AND USE THEREOF - The present invention relates to a novel set of 16 biomarkers, microarrays that provide for the detection thereof, an expression signature comprising 16 genes or a subset thereof, and the use thereof in determining the regulation status of Wnt/β-catenin signaling pathway. The regulation status of Wnt/β-catenin signaling pathway may be assayed based on the level of expression of one or more of these genes. The expression of these biomarkers may be used to evaluate Wnt/β-catenin pathway deregulation status; classify a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determine whether an agent modulates the Wnt/β-catenin signaling pathway; predict response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assign treatment to a subject; or evaluate the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. | 10-04-2012 |
Zhongjun Wu, Marriottsville, MD US
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20150352265 | BIOCOMPATIBLE COATING COMPOSITION - Provided herein are hemo-compatible, anti- and non-thrombogenic, heparin-based bioactive coatings for a surface to be contacted with blood, such as a surface of an oxygenator device (e.g., a Hollow Fiber Membrane (HFM) surface) or an artificial lung, which coatings include a quaternary ammonium salt and heparin complex (QUAT). According to example embodiments, the surface is treated with polyvinylpyrrolidone (PVP), followed by a coating layer of said quaternary ammonium salts and heparin complex (QUAT) to form a PVP-QUAT coating. According to other example embodiments, anionic functional groups are created on the one or more surfaces of the HFM by modifying the surface of the HFM using ionic complexes dissolved in a solvent mixture that includes major quantity of alcohol along with a minor quantity of organic dissolving agents. Also provided are methods of making the provided coatings, methods of coating a surface, oxygenator devices and artificial lungs that have been coated, and kits that include such coatings. | 12-10-2015 |
Zhongjun Wu, Woodstock, MD US
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20080199357 | Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system - The invention relates to an integrated centrifugal blood pump-oxygenator ( | 08-21-2008 |
20140037500 | Integrated Centrifugal Blood Pump-Oxygenator, an Extracorporeal Life Support System and a Method of De-Bubbling and Priming an Extracorporeal Life Support System - An integrated centrifugal blood pump-oxygenator ( | 02-06-2014 |