Patent application number | Description | Published |
20100086597 | MICROSPHERES FOR THE SUSTAINED RELEASE OF OCTREOTIDE WITH A LOW INITIAL BURST - This disclosure features microspheres and a method of making them. The microspheres are for sustained release of an octreotide compound with a low initial burst, comprising a poly(D,L-lactide-co-glycolide) polymer matrix and an octreotide compound dispersed in the polymer matrix. The microspheres release less than 1% of a total amount of the octreotide compound within 1 hour at 37° C. and pH 7.4. | 04-08-2010 |
20100143479 | METHOD OF MAKING SUSTAINED RELEASE MICROPARTICLES - Various embodiments of a method of preparing sustained release microparticles are described. In one embodiment, the method includes the steps of forming a dispersed phase of an active agent in a polymer and combining the dispersed phase with a continuous phase to form a microparticle dispersion. The method further includes the step of adding a measured amount of a dilution composition to the microparticle dispersion. It has been found herein that the various embodiments for preparing sustained release microparticles using various amounts of the dilution composition alters the release rate of the sustained microparticle for the specific active agent. | 06-10-2010 |
20120021018 | MICROSPHERES FOR THE SUSTAINED RELEASE OF OCTREOTIDE WITH A LOW INITIAL BURST - This disclosure features microspheres and a method of making them. The microspheres are for sustained release of an octreotide compound with a low initial burst, comprising a poly(D,L-lactide-co-glycolide) polymer matrix and an octreotide compound dispersed in the polymer matrix. The microspheres release less than 1% of a total amount of the octreotide compound within 1 hour at 37° C. and pH 7.4. | 01-26-2012 |
20140322336 | SUSTAINED-RELEASE MICROSPHERES AND METHODS OF MAKING AND USING SAME - Provided, among other things, are compositions and methods for making sustained-release microspheres, as well as a microsphere delivery system for the sustained release of an active agent. The microsphere delivery system comprises a homogenous mixture of biodegradable polymer, active agent, and a so-called release-modifying agent (including a pH-stabilizing agent), and provides protected and sustained release of active agents from the microsphere delivery system. According to the invention, the microspheres preferably are produced by an oil-in-water emulsion method that involves the production of a homogeneous oil phase prepared by mixing active agent and a release-modifying agent, such as arginine, with biodegradable polymer, each dissolved in organic solvent. The homogeneous oil phase desirably is then dispersed in an aqueous phase containing an emulsifying agent, followed by solvent removal, to produce the microspheres in which the active agent and release-modifying agent are distributed homogeneously throughout the biodegradable polymer matrix. | 10-30-2014 |
Patent application number | Description | Published |
20110007607 | GEOPHONE HAVING IMPROVED SENSITIVITY - A geophone utilizing an Alnico-9 magnet and having an improved sensitivity over Alnico-9 geophones of prior art through the lengthening of the parasitic air gap between the upper and lower pole pieces which, results in less magnetic flux leakage. The flux concentration through the geophone coils is increased and shifted towards the ends of the magnet. The increase of sensitivity of geophone of the present invention over prior art geophones may exceed 3 dB. The axial length of the coil bobbin is increased, and the positions of the electrical coils are moved towards the ends of the magnet to align with the shifted magnetic flux. | 01-13-2011 |
20110007608 | GEOPHONE HAVING IMPROVED DAMPING CONTROL - A geophone in which a coil bobbin assembly ideally includes a provision for receiving a third coil winding between the upper and lower coils. A third mass-tuning coil is wound around the bobbin whose purpose is to adjust the overall mass of the bobbin assembly with greater accuracy and precision than can be achieved by machining techniques alone. Mass is adjusted by adding or subtracting one or more turns of wire in the tuning coil. The tuning coil is preferably electrically shorted for increasing geophone damping. | 01-13-2011 |
20110007609 | VERTICAL GEOPHONE HAVING IMPROVED DISTORTION CHARACTERISTICS - A vertical geophone that includes a lower frequency spring, which forms part of the geophone electrical circuit, that is positioned directly on the lower end cap This arrangement eliminates the “spring supported by a spring” arrangement of prior art geophones to minimize geophone distortion and simplify tuning of the frequency springs. A contact spring is positioned between the lower frequency spring and the lower pole piece for forming part of the geophone electrical circuit. One surface of contact spring includes a plurality of wiper surfaces that ensure consistent sliding electrical contact against either the bottom surface of the lower pole piece or the upper surface of the lower frequency spring. The obverse surface of the contact spring is preferably spot welded to the other adjacent member. | 01-13-2011 |
20140022866 | MICRO-GEOPHONE - A micro geophone having pole pieces do not extend out around the sides of the magnet, thereby allowing a reduced geophone diameter for a given magnet diameter. The pole pieces are adhesively bonded to the magnet using an adhesive, which may be made suitably electrically conductive by silver or nickel fillers or non-conductive by mica fillers such as borosilicate glass micro-spheres. Axial space is economized by eliminating traditional spider retaining rings. The spider springs are seated directly against the coil form and secured by adhesive fillets disposed on the outward-facing spring circumferences. The spider springs include circumferential notches to receive adhesive. A two-piece bimetallic coil form of aluminum and a heavier material, joined by adhesive, is provided. Headers are affixed to the housing within the seats by adhesive. A straight or rounded chamfer at each of the geophone ends allows the overall geophone dimensions to be maximized. | 01-23-2014 |
20140022867 | MICRO-GEOPHONE - A micro geophone having pole pieces do not extend out around the sides of the magnet, thereby allowing a reduced geophone diameter for a given magnet diameter. The pole pieces are adhesively bonded to the magnet using an adhesive, which may be made suitably electrically conductive by silver or nickel fillers or non-conductive by mica fillers such as borosilicate glass micro-spheres. Axial space is economized by eliminating traditional spider retaining rings. The spider springs are seated directly against the coil form and secured by adhesive fillets disposed on the outward-facing spring circumferences. The spider springs include circumferential notches to receive adhesive. A two-piece bimetallic coil form of aluminum and a heavier material, joined by adhesive, is provided. Headers are affixed to the housing within the seats by adhesive. A straight or rounded chamfer at each of the geophone ends allows the overall geophone dimensions to be maximized. | 01-23-2014 |
20140022868 | MICRO-GEOPHONE - A micro geophone having pole pieces do not extend out around the sides of the magnet, thereby allowing a reduced geophone diameter for a given magnet diameter. The pole pieces are adhesively bonded to the magnet using an adhesive, which may be made suitably electrically conductive by silver or nickel fillers or non-conductive by mica fillers such as borosilicate glass micro-spheres. Axial space is economized by eliminating traditional spider retaining rings. The spider springs are seated directly against the coil form and secured by adhesive fillets disposed on the outward-facing spring circumferences. The spider springs include circumferential notches to receive adhesive. A two-piece bimetallic coil form of aluminum and a heavier material, joined by adhesive, is provided. Headers are affixed to the housing within the seats by adhesive. A straight or rounded chamfer at each of the geophone ends allows the overall geophone dimensions to be maximized. | 01-23-2014 |
20140022869 | MICRO-GEOPHONE - A micro geophone having pole pieces do not extend out around the sides of the magnet, thereby allowing a reduced geophone diameter for a given magnet diameter. The pole pieces are adhesively bonded to the magnet using an adhesive, which may be made suitably electrically conductive by silver or nickel fillers or non-conductive by mica fillers such as borosilicate glass micro-spheres. Axial space is economized by eliminating traditional spider retaining rings. The spider springs are seated directly against the coil form and secured by adhesive fillets disposed on the outward-facing spring circumferences. The spider springs include circumferential notches to receive adhesive. A two-piece bimetallic coil form of aluminum and a heavier material, joined by adhesive, is provided. Headers are affixed to the housing within the seats by adhesive. A straight or rounded chamfer at each of the geophone ends allows the overall geophone dimensions to be maximized. | 01-23-2014 |
Patent application number | Description | Published |
20100194186 | SYSTEM AND METHOD FOR CONTROL OF DISTRIBUTED POWER RAIL VEHICLE - In a system and method for controlling a distributed power rail vehicle consist, each of at least one powered rail vehicle in the rail vehicle consist is designated for operation as a remote trail. Based on the designation, a respective brake pipe valve of each of the at least one powered rail vehicle is automatically operated to a cut-out mode. Upon initiation of a service, an emergency, and/or a penalty brake application in the rail vehicle consist, the respective brake pipe valve of each of the at least one the powered rail vehicle is automatically operated to a cut-in mode. Upon completion of the service, emergency, and/or penalty brake application in the rail vehicle consist, the respective brake pipe valve of each of the at least one powered rail vehicle is automatically operated back to the cut-out mode. | 08-05-2010 |
20140081486 | ROLLBACK PROTECTION SYSTEM AND METHOD - A method for preventing rollback of a rail vehicle from a stopped condition, includes receiving a first signal indicative of the rail vehicle's location, and, in response to the first signal, selecting from a lookup table one of a first plurality of pre-determined values of a braking parameter and selecting from the lookup table one of a second plurality of pre-determined values of a tractive effort parameter. In response to an order for movement, the method includes applying brakes of the rail vehicle, according to the selected value of the braking parameter; establishing tractive effort of the rail vehicle, according to the selected value of the tractive effort parameter; and, then, releasing the brakes of the rail vehicle to establish motion of the rail vehicle from the stopped condition. | 03-20-2014 |
20140277845 | SYSTEM AND METHOD FOR REMOTELY CONTROLLING A VEHICLE CONSIST - A method for remotely controlling a vehicle system includes selectively identifying, among two or more consists in the vehicle system, a selected consist to remotely control. Each of the two or more consists including a propulsion-generating vehicle. The method also includes initiating remote control of the propulsion-generating vehicle in the selected consist and remotely controlling at least one of tractive effort or braking effort provided by the propulsion-generating vehicle in the selected consist using a remote control device. The at least one of tractive effort or braking effort provided by the propulsion-generating vehicle in the selected consist is controlled without remotely controlling tractive effort or braking effort provided by the propulsion-generating vehicle in at least one other consist in the vehicle system. | 09-18-2014 |
20140277846 | SYSTEM AND METHOD FOR CONTROLLING AUTOMATIC SHUT-OFF OF AN ENGINE - A method for controlling automatic shut off of an engine includes determining if a control system of a propulsion-generating vehicle is operating in a remote control mode or an onboard control mode. The operations of the vehicle are remotely controlled from an off-board source when the control system is in the remote control mode. The operations of the vehicle are controlled from onboard the vehicle when the control system is in the onboard control mode. The method also includes deactivating an automatic engine start-stop (AESS) device responsive to the control system being in or switched to the remote control mode. The AESS device automatically turns off an engine of the vehicle when operations of the engine are below one or more designated thresholds for at least a designated period of time. The AESS device is prevented from automatically turning the engine off when the AESS device is deactivated. | 09-18-2014 |
Patent application number | Description | Published |
20080258921 | Footwork Training System and Method - A system and method for evaluating an activity includes an article of clothing provided with a sensor capable of detecting the impact of the article of clothing, such as a shoe, on a surface. A system receives and interprets the pattern of impacts made during the performance of the activity. The system compares these impacts with those of a target routine. Iterations of the same performance may be stored in the system so that ongoing progress may be measured. The system may be used to enhance class teaching, in the home, or for Internet competition. The activity may include dance, yoga, martial arts, or similar activities. | 10-23-2008 |
20100107448 | Article of Footwear for Dancing - An article of footwear with a pivot portion including a plurality of flex grooves is disclosed. The plurality of flex grooves provides increased flexibility in different portions of a sole of the article. In addition, a periphery of the sole includes sole pods to increase the traction on the periphery of the sole. | 05-06-2010 |
20120191229 | Footwork Training System and Method - A system and method for evaluating an activity includes an article of clothing provided with a sensor capable of detecting the impact of the article of clothing, such as a shoe, on a surface. A system receives and interprets the pattern of impacts made during the performance of the activity. The system compares these impacts with those of a target routine. Iterations of the same performance may be stored in the system so that ongoing progress may be measured. The system may be used to enhance class teaching, in the home, or for Internet competition. The activity may include dance, yoga, martial arts, or similar activities. | 07-26-2012 |
20130118038 | Article of Footwear for Dancing - An article of footwear with a pivot portion including a plurality of flex grooves is disclosed. The plurality of flex grooves provides increased flexibility in different portions of a sole of the article. In addition, a periphery of the sole includes sole pods to increase the traction on the periphery of the sole. | 05-16-2013 |
Patent application number | Description | Published |
20120310611 | SYSTEM AND METHOD FOR SIMULATING DEPLOYMENT CONFIGURATION OF AN EXPANDABLE DEVICE - A system, method, computer-readable medium, apparatus, and device for simulating placement of an expandable device in a cavity is provided. For example, a three or more dimensional image of a cavity, e.g., a tubular cavity, geometry is acquired. A centerline of the cavity, and a perimeter of the cavity based on the centerline of the cavity and the three-dimensional image of the cavity geometry, are determined. The length of a wire of the expandable device as the wire rotates along the perimeter of the cavity in a deployment direction is determined. A pitch of the rotation of the wire based on a local diameter at the centerline site of rotation and in-air parameters of the expandable device is determined. A deployed device length of the expandable device along the centerline of the cavity is determined. A processor is usable to determine and/or calculate each of the above. | 12-06-2012 |
20130165871 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 06-27-2013 |
Patent application number | Description | Published |
20110270178 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 11-03-2011 |
20120041459 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 02-16-2012 |
20130066347 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 03-14-2013 |
20130066348 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 03-14-2013 |
20130131703 | METHOD AND APPARATUS FOR INCREASING BLOOD FLOW THROUGH AN OBSTRUCTED BLOOD VESSEL - A method of increasing blood flow through an obstructed blood vessel includes providing an expandable member substantially made of a mesh having a plurality of interstices. The expandable member is inserted into the blood vessel, positioned within the blood vessel with the proximal member end upstream of the distal member end and the member body located radially adjacent at least a portion of an obstruction, and expanded to bring at least a portion of the member body into contact with the obstruction. An outward radial force is exerted on the obstruction to dislodge at least one fragment from the obstruction and to enhance blood flow through the blood vessel past the obstruction. The at least one fragment is passed through at least one interstice of the member body in the radial direction, and is selectively retained within the expandable member. | 05-23-2013 |
Patent application number | Description | Published |
20110245205 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 10-06-2011 |
20120277192 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 11-01-2012 |
20130225577 | BICYCLIC DIAMINES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-29-2013 |
20140235641 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-21-2014 |
20140243290 | Aminopyrimidines as SYK Inhibitors - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 08-28-2014 |
20140349998 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS - The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I. | 11-27-2014 |
Patent application number | Description | Published |
20080233260 | RESISTANT STARCH-HYDROCOLLOID BLENDS AND USES THEREOF - Interacted starch products made up of resistant starch and hydrocolloid are provided which exhibit at least about 20% resistance to α-amylase digestion. The products are prepared by mixing together quantities of resistant starch and hydrocolloid in water with mixing and optional heating, followed by drying. Foods containing the interacted starch products are also disclosed. | 09-25-2008 |
20100034946 | RESISTANT STARCH-HYDROCOLLOID BLENDS AND USES THEREOF - Interacted starch products made up of resistant starch and hydrocolloid are provided which exhibit at least about 20% resistance to α-amylase digestion. The products are prepared by mixing together quantities of resistant starch and hydrocolloid in water with mixing and optional heating, followed by drying. Foods containing the interacted starch products are also disclosed. | 02-11-2010 |
20100255172 | High-Protein, Reduced-Carbohydrate Bakery And Other Food Products - A high-protein, low-carbohydrate bakery product comprising a first proteinaceous ingredient and a second proteinaceous ingredient selected from the group consisting of wheat protein isolate, wheat protein concentrate, devitalized wheat gluten, fractionated wheat protein, deamidated wheat gluten, hydrolyzed wheat protein, and combinations thereof are provided. Preferred bakery products further comprise an amount of resistant starch which replaces a portion of digestible carbohydrate therein. | 10-07-2010 |
20140314932 | EXPANDED PRODUCTS WITH HIGH PROTEIN CONTENT - High protein expanded products are produced by extrusion with unique blends of ingredients, such as wheat protein isolates, modified wheat starch, salts, gums and moisture. The mixture is extruded in a twin-screw extruder with the temperatures in the range of 50 to 140° C., screw speeds of 250 to 450 rpm and with a back pressure of 350 to 1200 psi for different recipes. A range of expanded wheat crisps and other expanded products with wheat protein contents ranging from 30 to 90% are obtained from this process. The expanded products have good cell structure with varying cell sizes when viewed under a microscope. This process can be used to develop a varied range of products such as, wheat crisps, wheat curls, wheat loops etc. The products may be used in nutritional or health bars and other comestible having a high protein and low carbohydrate content. | 10-23-2014 |
Patent application number | Description | Published |
20080226855 | HIGH IMPACT STRENGTH FILM AND NON-PVC CONTAINING CONTAINER AND POUCH AND OVERPPOUCH - A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130° C. | 09-18-2008 |
20080249247 | HIGH IMPACT STRENGTH FILM AND NON-PVC CONTAINING CONTAINER AND POUCH AND OVERPOUCH - A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about | 10-09-2008 |
20090169872 | RADIATION CURABLE COATINGS - Radiation curable coatings and methods of utilizing the coatings are provided. In a general embodiment, the present disclosure provides a coating composition containing about 15% to about 80% by weight of one or more radiation curable compounds such as polycarbonate acrylate oligomers, polyurethane acrylate oligomer, polyester acrylate oligomers, silicone-based acrylate oligomers, or a combination thereof, and about 10% to about 80% by weight of one or more acrylate monomers. | 07-02-2009 |
Patent application number | Description | Published |
20120006751 | Enhanced Clarification Media - Media and devices, such as depth filters including such media, wherein the media is impregnated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 01-12-2012 |
20120006752 | Enhanced Clarification Media - Media and devices, such as nitrocellulose-based filters, wherein the media is coated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 01-12-2012 |
20120168381 | Enhanced Clarification Media - Media and devices, such as depth filters including such media, wherein the media is impregnated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 07-05-2012 |
20120168382 | Enhanced Clarification Media - Media and devices, such as nitrocellulose-based filters, wherein the media is coated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 07-05-2012 |
Patent application number | Description | Published |
20100136004 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS - Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject. | 06-03-2010 |
20120039881 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS - Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject. | 02-16-2012 |
20130224223 | Compositions and Methods for Treating Neurological Disorders - Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject. | 08-29-2013 |
Patent application number | Description | Published |
20090073078 | Systems, Methods and Apparatuses for High Power Complementary Metal Oxide Semiconductor (CMOS) Antenna Switches Using Body Switching and External Component in Multi-Stacking Structure - Embodiments of the invention may provide for a CMOS antenna switch, which may be referred to as a CMOS SPDT switch. The CMOS antenna switch may operate at a plurality of frequencies, perhaps around 900 MHz, 1.9 GHz and 2.1 GHz according to an embodiment of the invention. The CMOS antenna switch may include both a receiver switch and a transmit switch. The receiver switch may utilize a multi-stack transistor with body substrate switching and attachment of external capacitor between drain and gate to block high power signals from the transmit path as well as to maintain low insertion loss at the receiver path. Exemplary embodiments of the CMOS antenna switch may provide for 38 dBm P 0.1 dB at multi bands (e.g., 900 MHz, 1.8 GHz, and 2.1 GHz). In addition, −60 dBc second and third harmonic performance up to 30 dBm input, may be obtained according to example embodiments of the invention. | 03-19-2009 |
20090174473 | Systems, Methods, and Apparatuses for Linear Envelope Elimination and Restoration Transmitters - Systems, methods, and apparatuses are provided for linear envelope elimination and restoration transmitters that are based on the polar modulation operating in conjunction with the orthogonal recursive predistortion technique. The polar modulation technique enhances the battery life by dynamically adjusting the bias level. Further, the analog orthogonal recursive predistortion efficiently corrects amplitude and phase errors in radio frequency (RF) power amplifiers (PA) and enhances the PA output capability. Additionally, even-order distortion components are used to predistort the input signal in a multiplicative manner so that the effective correction bandwidth is greatly enhanced. Also, the predistortion scheme, which uses instantaneously feed-backed envelope distortion signals, allows for correction of any distortion that may occur within the correction loop bandwidth, including envelope memory effects. | 07-09-2009 |
20110068636 | SYSTEMS AND METHODS FOR A SPDT SWITCH OR SPMT SWITCH WITH TRANSFORMER - A SPDT or SPMT switch may include a transformer having a primary winding and a secondary winding, where a first end of the secondary winding is connected to a single pole port, where a first end of the primary winding is connected to a first throw port; a first switch having a first end and a second end, where the first end is connected to ground; and a second switch, where a second end of the secondary winding is connected to both a second end of the first switch and a first end of the second switch, where a second end of the second switch is connected to a second throw port, where the first switch controls a first communication path between the single pole port and the first throw port, and where the second switch controls a second communication path between the second throw port and the single pole port. | 03-24-2011 |
20110221522 | SHARING OF INDUCTOR INTERSTAGE MATCHING IN PARALLEL AMPLIFICATION SYSTEM FOR WIRELESS COMMUNICATION SYSTEMS - A power amplifier system can include a plurality of driver amplifiers and a plurality of power amplifiers, where each driver amplifier and power amplifier includes at least one respective input port and at least one respective output port. The power amplifier system also includes a shared inductive device that provides common interstage matching between the respective output ports of the plurality of driver amplifiers and the respective input ports of the plurality of power amplifiers. The shared inductive device can be a shared inductor or a shared transformer. | 09-15-2011 |
20110285481 | LINEARIZATION SYSTEMS AND METHODS FOR VARIABLE ATTENUATORS - Systems and methods for provided for linearization systems and methods for variable attenuators. The variable attenuators can include series transistors along a main signal path from the input to output, as well as shunt transistors. A bootstrapping body bias circuit can be used with one or of the series transistors to allow the body of a connected transistor to swing responsive to a received RF input signal. As the RF signal increases and affects the gate-to-source voltage difference of a transistor, a bootstrapping body bias circuit can adaptively adjust the threshold voltage of the connected transistor and compensate the channel resistance variation resulting from gate-to-source voltage swing. The bootstrapping body bias circuit can be implemented using passive elements, active elements, or a combination thereof. | 11-24-2011 |
20120286839 | Systems and Methods for a Continuous, Linear, 360-Degree Analog Phase Shifter - Embodiments of the invention may be directed to a continuous analog phase shifter for radio frequency (RF) signals, which can be integrated on a CMOS process or another compatible process where inherent process-dependent passive components such as inductors and capacitors may have low quality factors. Insertion loss degradation for a given amount of phase shift may be compensated by using an active compensation circuit/device that smartly controls negative resistance generated from the compensation circuit/device to cancel out finite resistance of a network, leading to very small insertion loss variation. According to an example aspect of the invention, improved phase linearity and increased phase shift for a given size may be obtained by incorporating the compensation circuit/device. Thus, example analog phase shifters in accordance with example embodiments of the invention may have one or more of low insertion loss variation, small size, and good phase linearity over more than a 360 degree phase shift. | 11-15-2012 |
20120286860 | Systems and Methods for Minimizing Phase Deviation and/or Amplitude Modulation (AM)-to-Phase Modulation (PM) Conversion for Dynamic Range, Radio Frequency (RF) Non-Linear Amplifiers - Embodiments of the invention may provide systems and methods for minimizing phase deviation and/or amplitude modulation (AM)-to-phase modulation (PM) conversion for dynamic range, radio frequency (RF) non-linear amplifiers. In order to provide high dynamic range with reduced phase error, embodiments of the invention may utilize two separate paths for processing a signal. In particular, an input signal may be sampled and divided into each path. The first signal path may be used to shape a signal, and in particular, a voltage waveform at the load. The second signal path may be used for generating negative capacitances corresponding to the voltage waveform at the load. By combining the two signals at the load, a high-dynamic range, high-frequency, non-linear amplifier can be achieved that reduces phase error resulting from amplitude fluctuations with a relatively low unity-gain frequency (f | 11-15-2012 |
Patent application number | Description | Published |
20090309661 | Systems and Methods for Switching Mode Power Amplifier Control - Embodiments of the invention may provide for enhancement systems and methods for a power amplifier output control system. In an example embodiment, driver amplifier control may be provided in conjunction with power amplifier control to improve the power efficiency and/or dynamic range of the transmitter system. Furthermore, control over the driver amplifier may allow for relaxed power control slope, which may lessens the burden of digital to analog converters (DACs) in transmitter systems such as cellular transmitter systems. Also, systems and methods in accordance with example embodiments of the invention may provide a less sensitive solution to operational environment variations such as temperature, battery power voltage and implementation IC process. | 12-17-2009 |
20090309662 | Systems and Methods for Power Amplifier with Integrated Passive Device - Embodiments of the invention may provide for systems and methods for providing a power amplifier with integrated passive device, thereby improving the performance of the power amplifier. The power amplifier may include a signal amplification section, a power combining section, and a coupling device section that interconnects the signal amplification section and the power combining section. The signal amplification section may be implemented on a first substrate, and the power combining section may be implemented on a second substrate, where the first substrate and the second substrate may be different. The power combining section may be implemented by the integrated passive device (IPD) that may have characteristics of high performance passive device with flexibility of implementing diverse functions, including a notch filter, a low pass filter, and/or bypass capacitance for bias network. The power combining section implemented by the integrated passive device may have an improved power combining efficiency. | 12-17-2009 |
20100148866 | Systems and Methods for Power Amplifiers with Voltage Boosting Multi-Primary Transformers - Systems and methods may be provided for a power amplifier system. The systems and methods may include a plurality of power amplifiers, where each power amplifier includes at least one output port. The systems and methods may also include a plurality of primary windings each having a first number of turns, where each primary winding is connected to at least one output port of the plurality of power amplifiers, and a single secondary winding inductively coupled to the plurality of primary windings, where the secondary winding includes a second number of turns greater than the first number of turns. | 06-17-2010 |