Patent application number | Description | Published |
20080306099 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful. | 12-11-2008 |
20090041786 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful. | 02-12-2009 |
20100183620 | COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2 - The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. | 07-22-2010 |
20120183548 | IL-27 Antagonists for Treating Inflammatory Diseases - Methods of treatment using IL-27 antagonists are provided. Such methods include, but are not limited to, methods of treating steroid-resistant conditions, such as asthma, chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), and inflammatory bowel disease. Such antagonists include, but are not limited to, antibodies that bind IL-27 and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to its receptor); antibodies that bind the IL-27 receptor, alpha subunit, and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to the receptor); and soluble forms of IL-27RA. | 07-19-2012 |
20130142807 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful. | 06-06-2013 |
20130189262 | IL-27 Antagonists for Treating Inflammatory Diseases - Methods of treatment using IL-27 antagonists are provided. Such methods include, but are not limited to, methods of treating steroid-resistant conditions, such as asthma, chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), and inflammatory bowel disease. Such antagonists include, but are not limited to, antibodies that bind IL-27 and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to its receptor); antibodies that bind the IL-27 receptor, alpha subunit, and inhibit IL-27-mediated signaling (such as, for example, by blocking binding of IL-27 to the receptor); and soluble forms of IL-27RA. | 07-25-2013 |
20130302322 | METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) - Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis and associated conditions, methods of treating systemic lupus erythematosus and associated conditions, and methods of treating multiple sclerosis. | 11-14-2013 |
20140079699 | METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) - Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating inflammatory conditions, such as rheumatoid arthritis. | 03-20-2014 |
20140314785 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful. | 10-23-2014 |
Patent application number | Description | Published |
20120316989 | METHODS AND SYSTEMS FOR FACILITATING COMPARISON SHOPPING WITH GEOGRAPHICALLY-SPECIFIC, REAL-TIME PRODUCT INVENTORY INFORMATION - Consistent with some embodiments of the invention, a web-based comparison shopping and marketplace service enables a user to search for and/or browse products of interest, and then obtain geographically-relevant, real-time product availability and pricing information for a product of interest that is offered by one or more physical retail stores. Additionally, with some embodiments, the service enables a user to conclude a purchase transaction for a product that is located at a retail store, and then provides the user with driving directions from the user's location to the retail store. | 12-13-2012 |
20130054321 | PRODUCT-BASED ADVERTISING - A method and a system that identify seller ads to potential buyers within a network-based commerce system are provided. The method and system may operate to receive a request including a product identification from a seller, and assign to the seller, based on a distance function and the product identification, a matching identification entry included in a set of identification entries. The request may also include financial metrics. The method and system may further include operations to identify one or more seller ads associated with the matching identification entry, as determined by a distance measured between the matching identification entry and at least one extracted identification entry extracted from a selected content page and included in the set of identification entries. The identification of the one or more seller ads may also be determined by a relevance function based on the financial metrics. | 02-28-2013 |
20130246172 | PRODUCT-BASED ADVERTISING - A method and a system that identify seller ads to potential buyers within a network-based commerce system are provided. The method and system may operate to receive a request including a product identification from a seller, and assign to the seller, based on a distance function and the product identification, a matching identification entry included in a set of identification entries. The request may also include financial metrics. The method and system may further include operations to identify one or more seller ads associated with the matching identification entry, as determined by a distance measured between the matching identification entry and at least one extracted identification entry extracted from a selected content page and included in the set of identification entries. The identification of the one or more seller ads may also be determined by a relevance function based on the financial metrics. | 09-19-2013 |
20140278988 | PRODUCT-BASED ADVERTISING - A method and a system that identify seller ads to potential buyers within a network-based commerce system are provided. The method and system may operate to receive a request including a product identification from a seller, and assign to the seller, based on a distance function and the product identification, a matching identification entry included in a set of identification entries. The request may also include financial metrics. The method and system may further include operations to identify one or more seller ads associated with the matching identification entry, as determined by a distance measured between the matching identification entry and at least one extracted identification entry extracted from a selected content page and included in the set of identification entries. The identification of the one or more seller ads may also be determined by a relevance function based on the financial metrics. | 09-18-2014 |
Patent application number | Description | Published |
20140173307 | Interfacing Dynamic Hardware Power Managed Blocks and Software Power Managed Blocks - A method and apparatus for interfacing dynamic hardware power managed blocks and software power managed blocks is disclosed. In one embodiment, and integrated circuit (IC) may include a number of power manageable functional units. The functional units maybe power managed through hardware, software, or both. Each of the functional units may be coupled to at least one other functional unit through a direct communications link. A link state machine may monitor each of the communications links between functional units, and may broadcast indications of link availability to the functional units coupled to the link. Responsive to a software request to shut down a given link, or a hardware initiated shutdown of one of the functional units coupled to the link, the link state machine may broadcast and indication that the link is unavailable. | 06-19-2014 |
20140181571 | MANAGING FAST TO SLOW LINKS IN A BUS FABRIC - Systems and methods for managing fast to slow links in a bus fabric. A pair of link interface units connect agents with a clock mismatch. Each link interface unit includes an asynchronous FIFO for storing transactions that are sent over the clock domain crossing. When the command for a new transaction is ready to be sent while data for the previous transaction is still being sent, the link interface unit prevents the last data beat of the previous transaction from being sent. Instead, after a delay of one or more clock cycles, the last data beat overlaps with the command of the new transaction. | 06-26-2014 |
20140181824 | QOS INBAND UPGRADE - Systems and methods for upgrading QoS levels of older transactions based on the presence of higher level QoS transactions in a given queue. A counter may be maintained to track the number of transactions in a queue that are assigned a corresponding QoS level. Each separate QoS level can have a corresponding counter. When a transaction is received by the queue, the counter corresponding to the QoS level of the transaction is incremented. When a transaction leaves the queue, the transaction is upgraded to the highest QoS level with a non-zero counter. Also, when the transaction leaves the queue, the counter corresponding to the original QoS level of the transaction is decremented. | 06-26-2014 |
20140241376 | Apparatus and Method for Controlling Transaction Flow in Integrated Circuits - Various embodiments of a method and apparatus for controlling transaction flow in a communications fabric is disclosed. In one embodiment, an IC includes a communications fabric connecting multiple agents to one another. Each agent may include an interface coupling itself to at least one other agent. Each interface may include multiple queues for storing information corresponding to pending transactions. Also included in each interface is an arbitration unit and control logic. The control logic may determine which transactions are presented to the arbitration unit for arbitration. In one embodiment, the control logic may inhibit certain transactions from being presented to the arbitration unit so that other higher priority transactions may advance. In another embodiment, the control logic may reduce the priority level of some transactions for arbitration purposes to prevent the blocking of other higher priority transactions. | 08-28-2014 |
20140304441 | PROTOCOL CONVERSION INVOLVING MULTIPLE VIRTUAL CHANNELS - Embodiments of a bridge circuit and system are disclosed that may allow converting transactions from one communication protocol to another. The bridge circuit may be coupled to a first bus employing a first communication protocol, and a second bus employing a second communication protocol. The second bus may include a plurality of virtual channels. The bridge circuit may be configured to receive transactions over the first bus, and convert the transactions to the second communication protocol, and to assign the converted transaction to one of the plurality of virtual channels. The bridge circuit may be further configured store the converted transaction. A plurality of limited throughput signals may be generated by the bridge circuit dependent upon a number of available credits for the plurality of virtual channels. | 10-09-2014 |
20150026041 | TRANSACTION FLOW CONTROL USING CREDIT AND TOKEN MANAGEMENT - Embodiments of a local interface unit are disclosed that may allow for managing credits and tokens as part of flow control method. The local interface unit may include a transmit unit and a receive unit. The transmit unit may be configured to receive credits and tokens, determine an available number of credits based on the number received tokens, determine an available number of tokens based on the number of received tokens, and send the available credits to an arbitration unit. The available credits may then be updated, by the transmit unit in response to receiving a selected transaction from the arbitration, and the transmit unit may then transmit the selected transaction, and update the available credits and the available tokens once the transaction has been sent. The receive unit may be configured to send credits and tokens to a transmit unit, and receive a transaction sent by a transmit unit. | 01-22-2015 |
Patent application number | Description | Published |
20130022069 | HIGH POWER SURFACE MOUNT TECHNOLOGY PACKAGE FOR SIDE EMITTING LASER DIODE - The present invention relates to the packaging of high power laser(s) in a surface mount technology (SMT) configuration at low-cost using wafer-scale processing. A reflective sidewall is used to redirect the output emission from edge-emitting lasers through an optical element (e.g., a diffuser, lens, etc.). A common electrical pad centered inside the package provides p-side connection to multiple laser diodes (i.e. for power scalability). Thick plating (e.g. 75 um to 125 um) with a heat and electrically conductive material, e.g. copper, on a raised bonding area of a substrate provides good heat dissipation and spreading to the substrate layer during operation. The composite CTE of the substrate layer, e.g. AlN, and the heat/electrical conductive plating, e.g. Cu, substantially matches well with the laser substrates, e.g. GaAs-based, without the requirement for an additional submount. | 01-24-2013 |
20130201289 | LOW PROFILE DEPTH CAMERA - The use of one or more angled or curved and diverging light pipes or reflectors placed in a light source's, e.g. diode's, emission path at appropriate distances, angles and divergence, such that a diode's emission spot size is modified and or redirected from the diode's natural emission path to alternative planes at angle to the diode's natural emission path so that a diode emission safe spot size can be achieved on any plane at angle to the original diode natural emission path at minimum distances from the diode's point of emission. | 08-08-2013 |
20140104592 | POWER EFFICIENT PULSED LASER DRIVER FOR TIME OF FLIGHT CAMERAS - A time of flight camera device comprises an light source for illuminating an environment including an object with light of a first wavelength; an image sensor for measuring time the light has taken to travel from the light source to the object and back; optics for gathering reflected light from the object and imaging the environment onto the image sensor; driver electronics for controlling the light source with a high speed signal at a clock frequency; and a controller for calculating the distance between the object and the illumination unit. To minimize power consumption and resulting heat dissipation requirements, the light source/driver electronics are operated at their resonant frequency. Ideally, the driver electronics includes a reactance adjuster for changing a resonant frequency of the illumination unit and driver electronics system. | 04-17-2014 |
20140240692 | TIME-OF-FLIGHT (TOF) SYSTEM, SENSOR PIXEL, AND METHOD - A time-of-flight (TOF) sensor pixel is provided that performs in-pixel subtraction. The TOF sensor pixel includes a photodetector, a capacitor, and circuitry. The photodetector detects light pulses emitted at a clock frequency, after a time of flight, to provide a photocurrent. The capacitor integrates the photocurrent over an integration period, while the circuitry reverses a flow direction of the photocurrent through the capacitor at twice the clock frequency. At the end of the integration period, the capacitor provides a differential photocharge, corresponding to a capacitor voltage. The capacitor voltage is related to the time of flight of the light pulses and may be used to determine a distance to a target. | 08-28-2014 |