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Winkler, US

Barry A. Winkler, Stow, OH US

Patent application numberDescriptionPublished
20100294441METHOD AND APPARATUS FOR CURTAIN BATON WITH POSITIONABLE PIN - A curtain rod system adapted to be used with a window covering includes a baton for selectively positioning the window covering along a track, a stop member selectively engaged with a portion of the track for maintaining the position of the window covering at a selectable location along the track, the stop member operatively connected to the baton, a resilient member for providing a force to engage the stop member with the portion of the track to maintain the window covering at the selected location along the track, the resilient member operatively connected to the stop member, wherein the stop member can be selectively disengaged from the track by a force exerted on the baton, the force acting on the resilient member to disengage the stop member from the track and allow the stop member to slide freely along the track so the baton may selectively position the window covering.11-25-2010

Bernard Winkler, Land O Lakes, FL US

Patent application numberDescriptionPublished
20110185906Height Adjustable Beverage Brewer - A beverage brewer assembly has a base configured to rest on a surface, an upward facing vessel support, and a tower coupled to and extending up from the base. The tower has a stationary lower section and an upper section vertically height adjustable relative to the lower section. A head is coupled to the upper section of the tower and has a cantilevered section extending forward from the tower and spaced above the vessel support. A height adjust mechanism includes a vertically oriented male threaded shaft interconnecting the upper and lower sections of the tower. Relative rotation between the male threaded shaft and a female threaded element carried on a part of the tower selectively raises and lowers the vertical position of the upper section and head relative to the lower section and base.08-04-2011

Brennan Winkler, South Jordan, UT US

Patent application numberDescriptionPublished
20120245100PLASMID FOR EXPRESSION OF TRANSGENES IN PLANTS - A plasmid for use in transferring a chicken anemia virus apoptin coding sequence into a plant includes a binary vector suitable for transferring DNA from 09-27-2012

Bret D. Winkler, South Jordan, UT US

Patent application numberDescriptionPublished
20080212035System and method for aligning RGB light in a single modulator projector - A projection system that includes a singe light modulation device and a plurality of light sources of different wavelengths. Each wavelength of light is incident on the light modulation device at a spatially distinct location and a temporally distinct time. The use of a scanning mirror allows the projection system to sequentially form, in full-color, each of the columns or rows of an image. The projection system is characterized by the reduction of color separation or the rainbow effect due to the rendering of each column or row in full color.09-04-2008
20090002644INVISIBLE SCANNING SAFETY SYSTEM - An invisible scanning safety system for use with laser projection systems that includes sensors monitoring less than the entire laser accessible region such that the region monitored is reduced to almost the absolute minimum, to thereby prevent unwarranted stoppages or disturbances in projection. The system may also monitor a 360 degree region around the lens of the laser projector, a wedge-shaped region, a pyramid-shaped region or a chimney-shaped region.01-01-2009

Patent applications by Bret D. Winkler, South Jordan, UT US

Bruce L. Winkler, Madison, WI US

Patent application numberDescriptionPublished
20120223216STERILIZATION SYSTEM WITH ULTRAVIOLET EMITTER FOR ERADICATING BIOLOGICAL CONTAMINANTS - An exemplary sterilization system includes a self-propelled robotic mobile platform for locating and eradicating infectious bacterial and virus strains on floors (and objects thereon), walls, cabinets, angled structures, etc., using one or more ultraviolet light sources. A controller allows the system to adjust the quantity of ultraviolet light received by a surface by, for example, changing the intensity of energy input to a ultraviolet light source, changing a distance between a ultraviolet light source and a surface being irradiated, changing the speed/movement of the mobile platform to affect time of exposure, and/or by returning to contaminated areas for additional passes. The mobile platform may include a sensor capable of detecting fluorescence of biological contaminants irradiated with ultraviolet light to locate contaminated areas. The system is thus capable of “seek and destroy” functionality by navigating towards contaminated areas and irradiating those areas with ultraviolet light accordingly.09-06-2012

Chad M. Winkler, Glen Cargon, IL US

Patent application numberDescriptionPublished
20080279041FLUIDIC MIXER WITH CONTROLLABLE MIXING - In one embodiment of the disclosure, a fluid mixing device comprises a flow duct, with a wall having an inner surface defining a fluid flow path for a primary flow, and at least one deployable and retractable projection. The projection is adapted to controllably generate at least one secondary flow adjacent the inner surface. In other embodiments, methods are provided of controllably mixing at least one fluid within a fluid mixing device.11-13-2008
20120320709FLUIDIC MIXER WITH CONTROLLABLE MIXING - In one embodiment of the disclosure, a fluid mixing device comprises a flow duct, with a wall having an inner surface defining a fluid flow path for a primary flow, and at least one deployable and retractable projection. The projection is adapted to controllably generate at least one secondary flow adjacent the inner surface, In other embodiments, methods are provided of controllably mixing at least one fluid within a fluid mixing device.12-20-2012

Chad M. Winkler, Glen Carbon, IL US

Patent application numberDescriptionPublished
20120145808METHOD AND APPARATUS FOR VARIABLE EXHAUST NOZZLE EXIT AREA - A nozzle effective exit area control system is created with a convergent-divergent nozzle with a divergent portion of the nozzle having a wall at a predetermined angle of at least 12° from the freestream direction. Disturbance generators are located substantially symmetrically oppositely on the wall to induce flow separation from the wall with the predetermined wall angle inducing flow separation to extend upstream from each disturbance generator substantially to a throat of the nozzle pressurizing the wall and reducing the effective area of the jet flow at the nozzle exit.06-14-2012
20140145001METHOD AND APPARATUS FOR NOZZLE THRUST VECTORING - A thrust vectoring system is created with a convergent-divergent nozzle having a total angle no greater than 150 degrees. A divergent portion of the nozzle has a wall at a predetermined angle of at least 12° from the freestream direction. A disturbance generator is located on the wall to induce flow separation from the wall with the predetermined wall angle sufficient for the induced flow separation to extend upstream from disturbance generator substantially to a throat of the nozzle pressurizing the wall and creating a net vector angle in jet flow through the nozzle.05-29-2014

Cheryl Winkler, Gaithersburg, MD US

Patent application numberDescriptionPublished
20100297660SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH RENAL DISEASE - Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.11-25-2010

Daniel Winkler, Melbourne Beach, FL US

Patent application numberDescriptionPublished
20090213227DIGITAL CAMERA FOR USE IN CONNECTION WITH COMPUTER SYSTEMS AND RELATED METHODS - A computer system includes a server configured to host a website for displaying images having at least one of a plurality of image categories associated therewith, and at least one digital camera operable to capture and communicate the images to the server. The digital camera includes an image sensor, and a processor cooperating with said image sensor and said server for capturing the images based upon a selected image category from among the plurality thereof and communicating the images to said server. The processor sets at least one attribute of the images based upon the selected image category.08-27-2009

Daniel S. Winkler, Mesa, AZ US

Patent application numberDescriptionPublished
20080302500REUSABLE MOLD FORMING TOOL - Embodiments of the disclosure provide methods, apparatus, and articles for making a plurality of molds described by CAD data in machine readable form using a reusable mold-forming device. Various embodiments include configuring a plurality of adjustable actuators fixed to a base of a mold-forming device, where the top surface of the adjustable actuators takes the form of the mold required to make the part described by the CAD data. The adjustable actuators may then be readjusted to form another mold surface.12-11-2008

David Winkler, Palatine, IL US

Patent application numberDescriptionPublished
20110273378MOBILE DEVICE WITH TEMPERATURE SENSING CAPABILITY AND METHOD OF OPERATING SAME - The present invention relates to electronic devices such as mobile devices, and methods of operating such devices. In one embodiment of the invention, the electronic device includes first and second temperature sensors positioned at different respective locations on the electronic device and at least one processing device. The first and second temperature sensors respectively output first and second signals indicative of the respective temperatures experienced at those respective sensors. The at least one processing device (i) receives the first and second signals respectively from the first and second temperature sensors respectively and generates based thereon an indication of a difference or a relationship between the first and second temperatures, and (ii) determines an operational context of the electronic device based at least in part upon the difference. In an additional embodiment, other sensor information from one or more other sensors is taken into account in determining the operational context.11-10-2011

David A. Winkler, Spring Grove, IL US

Patent application numberDescriptionPublished
20120159220Portable Electronic Device and Method for Recovering Power to a Rechargeable Battery Used Therein - A portable electronic device employs a method for recovering power to a rechargeable battery used therein when the battery is in a low state of charge. The portable electronic device includes at least a power management subsystem (PMS), a main processor subsystem, and the battery. When the battery is incapable of supplying boot-up power to the processor subsystem, power is provided from a battery charger to the PMS to power-up the PMS. The PMS then determines the battery's type and a state-of-charge (SOC) parameter for the battery, and compares the SOC parameter to a threshold, which is based on at least the battery type. If the SOC parameter is less than the threshold, power is provided from the battery charger to the battery for use in recharging the battery. Otherwise, power is supplied from the battery to the processor subsystem to facilitate general operation of the portable electronic device.06-21-2012
20140192480MOBILE COMPUTING DEVICE DOCK STATION WITH HEADSET JACK HEAT PIPE INTERFACE - An improved electronic communications system 07-10-2014

David P. Winkler, Palatine, IL US

Patent application numberDescriptionPublished
20120068952USER COMPUTER DEVICE WITH TEMPERATURE SENSING CAPABILITIES AND METHOD OF OPERATING SAME - A user computer device is provided that comprises a temperature sensitive touchscreen having a temperature sensitive user interface comprising multiple thermal energy emitter/detector devices, such as thermocouples. The multiple thermal energy emitter/detector devices are capable both of detecting thermal energy and emitting thermal energy. The temperature sensitive user interface generates thermal patterns that may be transferred to other thermally sensitive electronic devices or that may be used to authenticate the user computer device. The user computer device also can detect and thermally communicate with a thermal energy docking station and, based on thermal recognition, activate applications displayed on the temperature sensitive touchscreen. Further, the user computer device can auto-bias a temperature of the temperature sensitive user interface in order to better assure proper operation of the temperature sensitive user interface in all operating conditions.03-22-2012
20130135220Active Styluses for Interacting with a Mobile Device - An active stylus or a method performed by an active stylus for interacting with a mobile device, wherein the mobile device has at least one sensor (e.g., a thermocouple junction), and wherein the stylus has at least one signal source (e.g., an analog heat source) that produces at least one signal (e.g., at least one analog temperature signal), wherein the at least one signal is configured to be detectable by the at least one sensor of the mobile device. The stylus also has at least one signal adjustment mechanism for changing the at least one signal and also has at least one transmitter (e.g., thermocouple junction) configured to transmit the at least one signal for receipt by the at least one sensor of the mobile device.05-30-2013
20130135262Mobile Device for Interacting with an Active Stylus - A mobile device or a method performed by a mobile device for interacting with a stylus, wherein the stylus has at least one sensor (e.g., a thermocouple junction), and wherein the mobile device has at least one signal source (e.g., an analog heat source) that produces at least one signal (e.g., at least one analog heat signal), wherein the at least one signal is configured to be detectable by the at least one sensor of the stylus. The mobile device also has at least one signal adjustment mechanism for changing the at least one signal and also has at least one transmitter (e.g., thermal active touch screen display) configured to transmit the at least one signal for receipt by the at least one sensor of the stylus.05-30-2013
20130222270Wearable display device, corresponding systems, and method for presenting output on the same - An electronic device can include detectors for altering the presentation of data on one or more displays. In a wearable electronic device, a flexible housing can be configured to enfold about an appendage of a user, such as a user's wrist. A display can disposed along a major face of the flexible housing. A control circuit can be operable with the display. A gaze detector can be included to detect a gaze direction, and optionally a gaze cone. An orientation detector can be configured to detect an orientation of the electronic device relative to the user. The control circuit can alter a presentation of data on the display in response to a detected gaze direction, in response to detected orientation of the wearable electronic device relative to the user, in response to touch or gesture input, or combinations thereof. Secondary displays can be hingedly coupled to the electronic device.08-29-2013
20140141816Method for Managing Notifications in a Communication Device - A method and apparatus of an electronic device for managing notifications is disclosed herewith. The method includes identifying a plurality of notifications associated with one or more electronic devices. The method further determines context data of the plurality of notifications based, at least in part, on their association with at least one remote device. The method then determines an order of display of the plurality of notifications based on the context data. The method further provides the plurality of notifications based on the order of display.05-22-2014
20140162482ELECTRICAL CONNECTOR, METHODS AND SYSTEMS THEREFOR - A connector (06-12-2014

Patent applications by David P. Winkler, Palatine, IL US

David R. Winkler, St. Louis, MO US

Patent application numberDescriptionPublished
20100005827INSULATED COOLER - A cooler is particularly configured for application of any selected design or marking. Any design may be easily applied to a standard cooler configuration. The design can be protected with a cover. The cooler also has structure for ease of mounting to different objects, and can be readily stacked. The lid can selectively retain cold or warm packs to cool or heat the interior.01-14-2010

Duane L. Winkler, Shawnee, KS US

Patent application numberDescriptionPublished
20080254763METHOD FOR MANAGING WIRELESS DEVICES USING EXCEPTION MONITORING - An improved solution for managing use of a plurality of wireless devices is provided. In an embodiment of the invention, a usage policy is obtained for the plurality of wireless devices. Usage data for one or more of the plurality of wireless devices is compared against the usage policy, wherefrom an exception report is derived and created. In another embodiment, the exception report is analyzed for non-compliance and a customer is notified.10-16-2008
20080254786MANAGING WIRELESS DEVICES USING ACCESS CONTROL - An improved solution for managing wireless devices that uses access control is provided. In an embodiment of the invention, a method for managing wireless devices includes receiving a notification for one of the plurality of wireless devices, the notification indicating at least one of: an access attempt threshold is exceeded or the wireless device is displaced; and remotely locking the wireless device based on the notification.10-16-2008
20080255695METHOD FOR MANAGING WIRELESS DEVICES USING LIFECYCLE ANALYSIS - An improved solution for managing wireless devices that uses lifecycle analysis is provided. In an embodiment of the invention, the method for managing wireless devices includes obtaining data regarding at least one new wireless device; automatically evaluating a feasibility of redeploying at least one of a plurality of pre-existing wireless devices, based on the data regarding the at least one new wireless device; and identifying a distribution for the at least one of the plurality of pre-existing wireless devices, based on the automatically evaluating. In another embodiment, the distribution may include cascading and/or retiring the pre-existing wireless device(s).10-16-2008

Edward R. Winkler, St. Peters, MO US

Patent application numberDescriptionPublished
20110180719Radio Frequency Energy Deposition Analysis - Radio frequency energy deposition analysis can include receiving information defining one or more radio frequency sources. Information defining one or more objects interacting with energy from the radio frequency sources may also be received. Ray traces of radio frequency energy from the radio frequency source to the object may be calculated. Ray traces of radio frequency energy reflected off of the object can also be calculated. Finally, the radio frequency energy deposited onto the object from the ray traces can be determined. The deposited energy may be graphically displayed and queried.07-28-2011

Edward R. Winkler, St. Peter, MO US

Patent application numberDescriptionPublished
20100075533RANDOMLY-ACCESSIBLE ELECTRICAL BUSBAR WITH PROTECTIVE COVER AND ASSOCIATED MATING CONNECTOR - Apparatus and systems described herein provide for a randomly-accessible electrical busbar with a protective cover and an associated mating connector. Both the busbar and the associated mating connector have multiple, electrically conductive bristles protruding from a surface. The busbar is protected by a nonconductive fabric cover to reduce the risk of a person from accidentally contacting the electrically conductive bristles. A connection is made between the mating connector and the busbar by the bristles of the mating connector penetrating the protective fabric cover and interdigitating with the bristles of the busbar.03-25-2010

Erwin Winkler, Romeoville, IL US

Patent application numberDescriptionPublished
20090084742Retail Display Stand - A new retail display stand is particularly useful for retailing cosmetics. Product holders are mounted in interchangeable cases that are removably connected to a mounting rack. The cases are stacked on top of each other, and mounted side-by-side on the rack. Mating recesses and projections are shown on the top and bottom of each case to help prevent stacked cases from moving laterally with respect to each other. A forwardly-facing display surface on the front face of the case has a raised rim and a resiliently-mounted transparent overlay sheet that holds a thin, replaceable information sheet in position. A pull-out panel on the bottom of the cases that can be used to hold information about the products.04-02-2009

Felix Winkler, Manchester, NH US

Patent application numberDescriptionPublished
20110011888PRODUCT DISPENSING SYSTEM - A product dispensing system includes a flow control device configured to regulate a first ingredient. A pump module is configured to be coupled to a supply of a second ingredient. A controller is configured to provide a first control signal to the flow control device for controlling the supply of a first quantity of the first ingredient based upon, at least in part, a predetermined recipe. The controller is further configured to provide a second control signal to the pump module for controlling the supply of a first quantity of the second ingredient based upon, at least in part, the predetermined recipe. 01-20-2011

Gary Eugene Winkler, St. Louis, MO US

Patent application numberDescriptionPublished
20090149571METHODS AND SYSTEMS FOR CONVERTING WASTE INTO COMPLEX HYDROCARBONS - A method for receiving animal waste from animal confinements or other concentrated animal waste sources and for converting the waste into a complex hydrocarbon is described. The waste contains both liquids and solids. The method includes separating the liquids and solids into separate waste streams, controlling an amount of moisture in the solids waste stream such that the amount of moisture in the solid waste stream is compatible with a selected energy conversion process, and feeding the moisture controlled solid waste into the energy conversion process. The complex hydrocarbon may be suitable for use as a substitute or additive to petroleum-based asphalt binder.06-11-2009
20100202895MULTI-CHAMBERED PUMP - A multi-chambered pumping system is provided comprising an input cylinder configured to pump a source substance into a vessel and an effluent cylinder configured to receive an effluent from the vessel. The cylinders regulate the pressure of the source substance input into the vessel and recover the pressure of an effluent output from the vessel to pump additional quantities of source substance into the vessel. In each cylinder, a piston creates a boundary between two sections: a fluid section configured to receive working fluid and an effluent or input process section to receive the same. The fluid sections of the cylinders are in fluid communication. A guide rod is attached to each piston and may be operably sized to compensate for a pressure difference between a pressure at which the source substance is pumped into a vessel and the pressure at which an effluent is output from the vessel.08-12-2010
20110257307METHODS AND SYSTEMS FOR CONVERTING WASTE INTO COMPLEX HYDROCARBONS - A method for receiving animal waste from animal confinements or other concentrated animal waste sources and for converting the waste into a complex hydrocarbon is described. The waste contains both liquids and solids. The method includes separating the liquids and solids into separate waste streams, controlling an amount of moisture in the solids waste stream such that the amount of moisture in the solid waste stream is compatible with a selected energy conversion process, and feeding the moisture controlled solid waste into the energy conversion process. The complex hydrocarbon may be suitable for use as a substitute or additive to petroleum-based asphalt binder.10-20-2011

Patent applications by Gary Eugene Winkler, St. Louis, MO US

Hermann Winkler, Malvern, PA US

Patent application numberDescriptionPublished
20090130429Natural Grain Leather - A leather finishing process in which, in pertinent part, a warm water milling step is added after the base coat is applied to “crust” leather and cured. The warm water contains at least one dye fixation agent including but not limited to about 0.1-2.0% by weight of formic acid. Moreover, the base coat itself is an aqueous base coat containing at least two polymers such as an acrylic salt or a polyurethane salt. Between the polymeric constituents of the base coat, the acid fixation agent, and the use of the warm water milling step after the base coat has been applied and dried, a surprisingly natural feel to the leather is attained without loss of excellent adhesion, wear-resistance and other properties when the leather is completely finished.05-21-2009

Hugh Winkler, Dripping Springs, TX US

Patent application numberDescriptionPublished
20140070956Systems and Methods For Processing Drilling Data - Systems and methods for processing drilling data. One embodiment provides a method comprising building user-designed contexts (which can be designated as built-in contexts) for drilling structures. The method also comprises orchestrating module execution within the user-designed contexts. The method further comprises providing data from the user-designed contexts to such modules via an interface. Some methods include monitoring drilling data to detect events (for instance departure from a pseudolog) and orchestrating module execution responsive thereto. The method can include exposing the orchestration of the execution of the module instances as a service. Moreover, some embodiments provide extra-contextual application program interfaces. In addition, or in the alternative, some embodiments schedule the orchestration of the modules based on declarations related to the inputs and/or outputs of the modules.03-13-2014

James V. Winkler, Denver, CO US

Patent application numberDescriptionPublished
20080261991Reducing Side Effects of Tramadol - The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.10-23-2008
20100144644METAL-BINDING COMPOUNDS AND USES THEREFOR - The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.06-10-2010
20100249016METAL-BINDING COMPOUNDS AND USES THEREFOR - The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.09-30-2010
20120018333Reducing Side Effects of Tramadol - The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.01-26-2012
20130090292TREATMENT OF DEGENERATIVE JOINT DISEASE - The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.04-11-2013
20130171670DIAGNOSIS AND MONITORING OF INFLAMMATION, ISCHEMIA AND APPENDICITIS - The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal.07-04-2013
20130338166REDUCING SIDE EFFECTS OF TRAMADOL - The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.12-19-2013
20140256642TREATMENT OF DEGENERATIVE JOINT DISEASE - The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.09-11-2014

Patent applications by James V. Winkler, Denver, CO US

Jeffrey Winkler, Wynnewood, PA US

Patent application numberDescriptionPublished
20140050696NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE - The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.02-20-2014
20140107085Bifunctional AKR1C3 Inhibitors/Androgen Receptor Modulators and Methods of Use Thereof - The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.04-17-2014
20140371228NOVEL THERAPEUTIC AGENTS - The present invention includes a method of treating or preventing a disease or disorder such as a mycobacterial infection, a Gram-positive bacterium infection, a yeast infection, an inflammatory condition, an auto-immune disorder and/or a proliferative disorder in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of at least one compound of the invention, which includes clofazimine derivatives.12-18-2014

Jeffrey D. Winkler, Wynnewood, PA US

Patent application numberDescriptionPublished
20100298281Steroid-Derived Cyclopamine Analogs and Methods for Using the Same in the Prevention or Treatment of Cancer - The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.11-25-2010
20110306662Steroid-Derived Cyclopamine Analogs and Methods for Using the Same in the Prevention or Treatment of Cancer - The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.12-15-2011
20130203794COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER - The present invention relates to compounds for modulating sonic hedgehog signaling and preventing or treating cancer.08-08-2013

Patent applications by Jeffrey D. Winkler, Wynnewood, PA US

Jereld L. Winkler, Gilbert, AZ US

Patent application numberDescriptionPublished
20110311725APPARATUS AND METHODS FOR SAFELY PROVIDING HAZARDOUS REACTANTS - An apparatus for providing a reactant comprises a reactant space and a reservoir space. The reactant space comprises a chemical complex capable of evolving the reactant when heated. The reservoir space, in turn, is in gas communication with the reactant space. The apparatus is operative to heat the chemical complex when a pressure of the reactant in the reservoir space is below a predetermined set-point, and to cool the chemical complex when the pressure of the reactant in the reservoir space is above the predetermined set-point.12-22-2011

Jerry Winkler, Gilbert, AZ US

Patent application numberDescriptionPublished
20130126515RADIATION SHIELDING FOR A SUBSTRATE HOLDER - A reaction chamber including a substrate supporting member positioned within the reaction chamber, the reaction chamber having a first region and a second region, a shield positioned within the second chamber and movable with the substrate supporting member, and wherein the shield is adjacent at least a bottom surface of the substrate supporting member.05-23-2013
20130129577CHAMBER SEALING MEMBER - A reaction chamber including an upper region for processing a substrate, a lower region for loading a substrate, a susceptor movable within the reaction chamber, a first sealing member positioned on a perimeter of the susceptor, a second sealing member positioned between the upper region and the lower region, wherein the first and second sealing members are selectively engaged with one another to limit communication between the upper region and the lower region.05-23-2013
20130230814SUSCEPTOR HEATER SHIM - A substrate supporting assembly in a reaction space includes a heater, a substrate support member, and a shim positioned between the heater and the substrate support member. The shim may be removably secured between the heater and the substrate support member. The shim may further include an inner surface defining a perimeter of a gap. The gap may be further defined by a bottom surface of the substrate support member and a top surface of the heater. The substrate support member may further include a shoulder positioned radially outside of a substrate support position and wherein the shim inner surface is radially aligned with the substrate support member shoulder.09-05-2013
20140000843SUSCEPTOR HEATER AND METHOD OF HEATING A SUBSTRATE01-02-2014

John Winkler, Appleton, WI US

John M. Winkler, Mukwonago, WI US

Patent application numberDescriptionPublished
20080222990Fitting for a T-slot structure - A unitary fitting for mating with and coupling a plurality of T-slot structures. The fitting comprises at least two sections to mate with the T-slot structures, with each of the sections having a first end, a second end, an outer surface circumferentially surrounding said T-slot structure, and an inner surface being capable of mating with one of said T-slot structures. the inner surfaces has at least one rail that extends inwardly into a recess of the T-slot structures. The fitting is formed of one piece construction.09-18-2008

Joseph C. Winkler, Punta Gorda, FL US

Patent application numberDescriptionPublished
20080288202Method and apparatus for automatically testing a railroad interlocking - A railroad signal system interlocking is automatically tested. A control point interface corresponding to a predetermined function of the interlocking has an isolated section and a control section. The isolated section is connected with the interlocking and has a normal, inactivated state during operation of the interlocking, and an activated state for testing the interlocking by detecting an electrical characteristic representing the status of the predetermined function executed by the interlocking. The control section drives the isolated section to its activated state and receiving an output from the isolated section in response to the detected electrical characteristic, and delivers a status report.11-20-2008

Julie Winkler, Naperville, IL US

Patent application numberDescriptionPublished
20130018768PRICING CASH SETTLED ON-THE-RUN TREASURY FUTURES CONTRACTSAANM Sturm; FrederickAACI ChicagoAAST ILAACO USAAGP Sturm; Frederick Chicago IL USAANM Boudreault; JamesAACI PalatineAAST ILAACO USAAGP Boudreault; James Palatine IL USAANM Grombacher; DanielAACI EvanstonAAST ILAACO USAAGP Grombacher; Daniel Evanston IL USAANM Winkler; JulieAACI NapervilleAAST ILAACO USAAGP Winkler; Julie Naperville IL US - The disclosed embodiments relate to determining a listing date, an expiration date and the cash settlement price of a futures contract, i.e. a Treasury Futures, for the delivery of the most recently issued, referred to as an on-the-run, US treasury Note of a particular maturity by reference to the U.S. Treasury Auction cycle and the difference between a resultant industry surveyed swap rate and a resultant industry surveyed swap spread of the respective tenors (time remaining until maturity) of the on-the-run treasury futures.01-17-2013
20130166474PRICING CASH SETTLED ON-THE-RUN TREASURY FUTURES CONTRACTS - The disclosed embodiments relate to determining a listing date, an expiration date and the cash settlement price of a futures contract, i.e. a Treasury Futures, for the delivery of the most recently issued, referred to as an on-the-run, US treasury Note of a particular maturity by reference to the U.S. Treasury Auction cycle and the difference between a resultant industry surveyed swap rate and a resultant industry surveyed swap spread of the respective tenors (time remaining until maturity) of the on-the-run treasury futures.06-27-2013

Kelly P. Winkler, Cartersville, GA US

Patent application numberDescriptionPublished
20100154453LINE SET BOX FOR PROTECTING REFRIGERANT LINES AND METHOD OF USE THEREOF - A line set box, and a method of use thereof, comprising a generally rigid conduit box panel having a removable front cover, wherein the box panel has knockouts and insertable sealing grommets enabling sealed passage of conduits from inside a structure to outside the structure. Thus, the conduit box functions to house and protect end portions of refrigerant lines, drain lines, and/or control lines of an air-conditioning system during construction of a building until the refrigerant lines and the control lines are connected to a compressor of the air-conditioning system located outside the building.06-24-2010

Kenneth William Winkler, Ridgefield, CT US

Patent application numberDescriptionPublished
20090114472MEASURING STANDOFF AND BOREHOLE GEOMETRY - Refracted ultrasonic waves are utilized to calculate tool standoff. An ultrasonic transmitter sends a wave toward (and into) the borehole wall at a critical incidence angle for refracted waves. The refracted wave travels along the borehole wall and continuously radiates energy back into the borehole at the critical angle. The refracted wave is detected by a receiver, and the travel time of the refracted acoustic wave from transmitter to receiver is measured and used to calculate standoff. By making repeated measurements at various azimuths (for instance, as the tool rotates), one or more caliper measurements can be made. The caliper measurements can be combined to yield two-dimensional geometry of the borehole. Measurements made at different azimuths and depths yield three-dimensional borehole geometry. Arrays of transmitter-receiver pairs can be used to obviate the need for varying azimuth.05-07-2009

Marie S. Winkler, Davisburg, MI US

Patent application numberDescriptionPublished
20080269366MICROPOROUS FILMS FROM COMPATIBILIZED POLYMERIC BLENDS - Disclosed herein are microporous films comprising polymer blends comprising at least two polymers and a compatibilizer. The films may also comprise at least one ethylene/α-olefin interpolymer and two different polyolefins which can be homopolymers. The ethylene/α-olefin interpolymers are block copolymers comprising at least a hard block and at least a soft block. In some embodiments, the ethylene/α-olefin interpolymer can function as a compatibilizer between the two polyolefins which may not be otherwise compatible. Methods of making the polymer blends and microporous films made from the polymer blends are also described.10-30-2008

Mark Winkler, Brooklyn, NY US

Patent application numberDescriptionPublished
20110045244ENGINEERING FLAT SURFACES ON MATERIALS DOPED VIA PULSED LASER IRRADIATION - Methods and apparatus for processing a substrate (e.g., a semiconductor substrate) is disclosed that includes irradiating at least a portion of the substrate surface with a plurality of short radiation pulses while the surface portion is exposed to a dopant compound. The pulses are selected to have a fluence at the substrate surface that is greater than a melting fluence threshold (a minimum fluence needed for the radiation pulse to cause substrate melting) and less than an ablation fluence threshold (a minimum fluence needed for the radiation pulse to cause substrate ablation). In this manner a quantity of the dopant can be incorporated into the substrate while ensuring that the roughness of the substrate's surface is significantly less than the wavelength of the plied radiation pulses.02-24-2011
20110100441MULTIJUNCTION PHOTOVOLTAIC DEVICE - Photovoltaic devices (e.g., solar cells) are disclosed that include at least three radiation absorbing layers, each capable of absorbing radiation over a different wavelength range of the solar radiation spectrum. Any two of these three wavelength ranges can be partially overlapping, or alternatively they can be distinct. The layers are disposed relative to one another so as to form two junctions, each of which includes a depletion region. In some cases, the radiation absorbing layers can collectively absorb radiation over a wavelength range that spans at least about 60%, or 70%, or 80%, and preferably 90% of the solar radiation wavelength spectrum. By way of example, in some embodiments, one layer can exhibit significant absorption of solar radiation (e.g., it can absorb at least one radiation wavelength at an absorptance greater than about 90%) at wavelengths less than about 0.7 microns while another layer can exhibit significant absorption of the solar radiation at wavelengths in a range of about 0.7 microns to about 1 micron. The third layer can in turn exhibit a significant absorption of solar radiation at wavelengths greater than about 1 micron.05-05-2011

Mark Alan Winkler, Iowa City, IA US

Patent application numberDescriptionPublished
20090307031SYSTEM AND METHOD FOR DATA COLLECTION, REPORTING, AND ANALYSIS OF FLEET VEHICLE INFORMATION - Presented is a system and method of providing centralized management and analysis of fleet information. The system includes a centralized fleet information management server accessible via a communications network to thin clients. The communications network may be the Internet, and the thin clients are required to have only a web browser application to fully access the functionality of the server. A portable computing device, such as a Windows CE or Palm compatible device, may be used with an installed application program to conduct on-site, off-line inspections. The portable device includes a local database that may be populated with fleet information downloaded from the fleet information management server. Upon completion of the on-site inspection, the data stored in the local database may be uploaded to the server. The server may be used by thin clients to generate various reports based on the fleet data, including the estimation of operating cost savings.12-10-2009

Mark G. Winkler, Ridgefield, CT US

Patent application numberDescriptionPublished
20080230534BAKE PLATE LID CLEANER AND CLEANING METHOD - A method and system for positioning a wafer on a bake plate in a processing module that includes lowering a bake plate cover assembly over the wafer during a baking process, raising the bake plate cover assembly after the baking process, removing the wafer, determining whether the bake plate cover assembly requires cleaning, then either processing another wafer if the cover assembly does not need cleaning or establishing a cleaning process for the bake plate cover assembly if the cover does need cleaning. Automated sensing of the state of the cover assembly may be employed, and cleaning process may be automatically performed in response to the cleaning need determination.09-25-2008

Mark T. Winkler, New York, NY US

Patent application numberDescriptionPublished
20130288463METHOD FOR PRODUCING THIN LAYERS OF CRYSTALLINE OR POLYCRYSTALLINE MATERIALS - Method for making thin crystalline or polycrystalline layers. The method includes electrochemically etching a crystalline silicon template to form a porous double layer thereon, the double layer including a highly porous deeper layer and a less porous shallower layer. The shallower layer is irradiated with a short laser pulse selected to recrystallize the shallower layer resulting in a crystalline layer. Silicon is deposited on the recrystallized shallower layer and the silicon is irradiated with a short laser pulse selected to crystalize the silicon leaving a layer of crystallized silicon on the template. Thereafter, the layer of crystallized silicon is separated from the template. The process of the invention can be used to make optoelectronic devices.10-31-2013
20140144497ATOMIC LAYER DEPOSITION FOR PHOTOVOLTAIC DEVICES - A photovoltaic device and method include a substrate, a conductive layer formed on the substrate and an absorber layer formed on the conductive layer from a Cu—Zn—Sn containing chalcogenide material. An emitter layer is formed on the absorber layer and a buffer layer is formed on the emitter layer including an atomic layer deposition (ALD) layer. A transparent conductor layer is formed on the buffer layer.05-29-2014
20140147958ATOMIC LAYER DEPOSITION FOR PHOTOVOLTAIC DEVICES - A photovoltaic device and method include a substrate, a conductive layer formed on the substrate and an absorber layer formed on the conductive layer from a Cu—Zn—Sn containing chalcogenide material. An emitter layer is formed on the absorber layer and a buffer layer is formed on the emitter layer including an atomic layer deposition (ALD) layer. A transparent conductor layer is formed on the buffer layer.05-29-2014
20150027521LOW REFLECTION ELECTRODE FOR PHOTOVOLTAIC DEVICES - A method for forming a photovoltaic device includes forming a photovoltaic absorption stack on a substrate including one or more of I-III-VI01-29-2015
20150059855TITANIUM INCORPORATION INTO ABSORBER LAYER FOR SOLAR CELL - A method for fabricating a photovoltaic device includes forming a film including titanium on a conductive layer formed on a substrate. An absorber layer is formed including a Cu—Zn—Sn containing chalcogenide compound with a kesterite structure of the formula: Cu03-05-2015
20150059856TITANIUM INCORPORATION INTO ABSORBER LAYER FOR SOLAR CELL - A method for fabricating a photovoltaic device includes forming a film including titanium on a conductive layer formed on a substrate. An absorber layer is formed including a Cu—Zn—Sn containing chalcogenide compound with a kesterite structure of the formula: Cu03-05-2015

Patent applications by Mark T. Winkler, New York, NY US

Martin Winkler, Omaha, NE US

Patent application numberDescriptionPublished
20090076432Compression garment - A compression garment comprises a plurality of longitudinal yarns arranged to form a fabric having a length and generally parallel to the length, and a plurality of transverse elastomeric yarns connecting adjacent longitudinal yarns and equally spaced about a length of the longitudinal yarns. In a stretched state, the longitudinal yarns are spaced from one another and remain generally parallel to the length.03-19-2009
20130014544COMPRESSION GARMENT - A compression garment comprises a plurality of longitudinal wales arranged to form a fabric having a length and generally parallel to the length, and a plurality of secondary transverse elastomeric threads connecting adjacent longitudinal wales and equally spaced about a length of the longitudinal wales. In a stretched state, the longitudinal wales are spaced from one another and remain generally parallel to the length.01-17-2013
20140148742COMPRESSION GARMENT - A compression garment comprises a plurality of longitudinal wales arranged to form a fabric having a length and generally parallel to the length, and a plurality of secondary transverse elastomeric threads connecting adjacent longitudinal wales and equally spaced about a length of the longitudinal wales. In a stretched state, the longitudinal wales are spaced from one another and remain generally parallel to the length.05-29-2014

Patent applications by Martin Winkler, Omaha, NE US

Matthew Winkler, Austin, TX US

Patent application numberDescriptionPublished
20080274458NUCLEIC ACID QUANTITATION METHODS - The invention relates to a method of determining the amount of a target nucleic acid sequence in a sample, the method comprising: obtaining multiple distinguishable amplicons of the target nucleic acid sequence, each comprising a distinguishing tag and a target portion; amplifying the amplicons in a single reaction volume; and detecting nucleic acids amplified from the amplicons. Detection of the distinguishable amplicons can be varied in each of the steps of the method, which expands the dynamic range of the nucleic acid quantification methods and improves the reliability and accuracy of the methods.11-06-2008

Matthew Anderson Winkler, Metamora, IL US

Patent application numberDescriptionPublished
20090114861CONTROL SYSTEM FOR DYNAMIC ORIFICE VALVE APPARATUS AND METHOD - In a fluid transmission line, a valve comprising a housing that establishes a lumen for transmission of a fluid through said valve; a drive mechanism and a drive gear mounted in said housing to be selectively driven in a first or second rotational direction by said drive mechanism. The drive gear has a central throughhole and a plurality of pins around the central throughhole. A plurality of leaves are pivotally mounted on the pins, and oriented to extend radially inward into said central throughhole. A fixed extension has an annular aspect disposed in the drive gear, and has a plurality of engagement members disposed to operatively engage one of said leaves. The engagement members bias the leaves to close an orifice when said drive gear rotates in said first direction and to open the orifice when said drive gear rotates in said second direction. Each of the leaves maintains a substantially sealing engagement with each adjacent leaf throughout a range of motion of the leaves.05-07-2009

Matthew J. Winkler, Liberty Township, OH US

Patent application numberDescriptionPublished
20080243141SURGICAL INSTRUMENT WITH SEPARATE TOOL HEAD AND METHOD OF USE - Surgical instruments are disclosed in which an elongated shaft is used in conjunction with a separate, remotely actuable tool head for performing a procedure on a target tissue. The shaft has a tool engagement member carried at its distal end that is remotely actuable through the shaft to engage and release the tool head.10-02-2008
20100305562Ablation Device With Cooled Electrodes And Methods of Use - An electrosurgical end effector for ablating tissue is provided that comprises at least one electrically-conductive ablation member adapted to be connected to a source of RF energy, with the ablation member having a tissue engaging surface and an internal fluid passageway. Preferably, the end effector includes two electrically conductive ablation members that are electrically isolated from one another.12-02-2010
20120179153SURGICAL INSTRUMENT WITH SEPARATE TOOL HEAD AND METHOD OF USE - Surgical instruments are disclosed in which an elongated shaft is used in conjunction with a separate, remotely actuable tool head for performing a procedure on a target tissue. The shaft has a tool engagement member carried at its distal end that is remotely actuable through the shaft to engage and release the tool head.07-12-2012
20140025058ABLATION DEVICE WITH INTERNALLY COOLED ELECTRODES - An electrosurgical end effector for ablating tissue is provided that comprises at least one electrically-conductive ablation member adapted to be connected to a source of RF energy, with the ablation member having a tissue engaging surface and defining an internal fluid passageway. Preferably, the end effector includes two electrically conductive ablation members that are electrically isolated from one another and have their fluid passageways in fluid communication. Alternatively, the end effector may comprise four electrically conductive ablation members arranged as two pairs of ablation members, all of the ablation members having internal fluid passageways that are electrically isolated from each other, with the fluid passageways of each of the four ablation members being in fluid communication with each other.01-23-2014
20140142597OCCLUSION CLIP - An occlusion clamp comprising: (a) an occlusion tongs including a primary spring coupling a first longitudinal arm to a second longitudinal arm, the first longitudinal arm including a first linear occlusion surface configured to be parallel to and overlap a second linear occlusion surface of the second longitudinal arm, each of the first and second longitudinal arms having a free distal end; and, (b) a secondary spring removably coupled to the occlusion tongs.05-22-2014

Patent applications by Matthew J. Winkler, Liberty Township, OH US

Matthew M. Winkler, Austin, TX US

Patent application numberDescriptionPublished
20090197346COMPOSITIONS AND METHODS FOR PRESERVING RNA IN BIOLOGICAL SAMPLES - The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.08-06-2009
20120305846COMPOSITIONS AND METHODS FOR PRESERVING RNA IN BIOLOGICAL SAMPLES - The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.12-06-2012

Patent applications by Matthew M. Winkler, Austin, TX US

Max Winkler US

Patent application numberDescriptionPublished
20110170998Method and Apparatus for picking articles into order load supports in a completely automated and manless manner - The present invention relates to a system for picking a plurality of different articles in a fully automated manner, which are preferably stored in storage load supports (07-14-2011

Michael F. Winkler, Vicksburg, MS US

Patent application numberDescriptionPublished
20090018774Real time environmental measurement and reporting system for navigable waterways and method of use - COTS devices are integrated into a system employing custom software and custom hardware and software interfaces to collect and communicate data concerning current flows around fixed structure (e.g., inland locks, bridges, harbor structures, etc.) in various bodies of water (e.g., inland waterways, harbors, canals, etc.). Embodiments comprise: sensors and communications equipment, for example wireless systems that transmit sensor data to a lock house; lock house communications equipment that receive sensor data; a processor, e.g., a personal computer, with installed custom software and interface for processing data; an Automatic Identification System (AIS) transponder interfaced to the processor; an AIS installed in vessels to include an electronic vector chart display, such as may be installed in a towboat pilothouse; and an optional web-based database application for lock operators to record dam operation scenarios that may be used in research, investigations, and the like.01-15-2009

Nathan Winkler, New York, NY US

Patent application numberDescriptionPublished
20140030555MICROBIAL FUEL CELL, AND RELATED SYSTEMS AND METHODS - A microbial fuel cell is provided that includes a cell housing, a membrane dividing an internal chamber of the cell housing into an anode compartment and a cathode compartment, an anode including a graphite and first microorganisms contained in the anode compartment, a cathode including graphite and a second microorganisms contained in the cathode compartment, and a watercourse communicating the anode compartment and the cathode compartment with one another. A system including at least one microbial fuel cell and methods of operating the microbial fuel cell and system are also provided.01-30-2014

Patrick Winkler, East Troy, WI US

Patent application numberDescriptionPublished
20100182162Sealed Transmitter Assembly For Subsurface Utility Installations - An assembly (07-22-2010

Paul Winkler, Golden, CO US

Patent application numberDescriptionPublished
20100304426Analytical Methods for Measuring Synthetic Progesterone - Embodiments relating to methods, processes and systems for measuring progesterone are provided. In particular, methods permit measurement and quantification of synthetic and/or endogenous progesterone from a progesterone-containing blood fluid sample by measuring a progesterone carbon isotope ratio by mass spectrometry and calculating the fraction of synthetic progesterone in the sample from the isotope ratio. Also provided are methods of evaluating bioequivalence of a synthetic progesterone composition using any of the methods provided herein. In an embodiment, methods of precise measurements of plasma levels are described for detection of progesterone analytes such as total progesterone, endogenous animal progesterone, and synthetic progesterone. Correcting for fluctuations in endogenous progesterone levels following application of synthetic progesterone allows a significant reduction in the number of test subjects required to evaluate bioequivalence of a synthetic progesterone composition.12-02-2010

Peter Winkler, Hanover, NH US

Patent application numberDescriptionPublished
20130326038MANAGEMENT OF DATACENTERS FOR FAULT TOLERANCE AND BANDWIDTH - Upon receiving a request to improve one or more conditions of a datacenter network, a fault management system may analyze information of the datacenter network including communication patterns among services provided in the network. The fault management system determines one or more logical machines associated with one or more services to be moved from one or more devices to one or more other devices of the network. The fault management system may select these one or more logical machines for migration based on a cost function including factors for fault tolerance, bandwidth usage, number of moves and/or response time latency. The fault management system may improve the fault tolerance of the network without significantly affecting the bandwidth usage of the network.12-05-2013
20140323204DETERMINING GAME SKILL FACTOR - Data characterizing a quantifiable outcome for each of a plurality of game trials can be accessed. Each game trial can be associated with one of a plurality of players and a game. The game can be a digital game played on a computing platform. Using the accessed data, a first variance measure of the quantifiable outcome for all game trials associated with the plurality of players can be computed. For one or more of the plurality of players and using the accessed data, a second variance measure of the quantifiable outcome for the game trials associated with the one or more of the plurality of players can be computed. Based on at least the first variance measure and the second variance measure, a skill factor for the game can be computed. Data characterizing the skill factor can be provided. Related apparatus, systems, techniques, and articles are also described.10-30-2014
20150065226Determining Game Skill Factor - Data characterizing a quantifiable outcome for each of a plurality of game trials can be accessed. Each game trial can be associated with one of a plurality of players and a game. The game can be a digital game played on a computing platform. Using the accessed data, a first variance measure of the quantifiable outcome for all game trials associated with the plurality of players can be computed. For one or more of the plurality of players and using the accessed data, a second variance measure of the quantifiable outcome for the game trials associated with the one or more of the plurality of players can be computed. Based on at least the first variance measure and the second variance measure, a skill factor for the game can be computed. Data characterizing the skill factor can be provided. Related apparatus, systems, techniques, and articles are also described.03-05-2015

Patent applications by Peter Winkler, Hanover, NH US

Ralf Winkler, New Bern, NC US

Patent application numberDescriptionPublished
20110153105HOME APPLIANCE AND METHOD FOR OPERATING A HOME APPLIANCE - A home appliance includes an electronic controller with a trigger port which starts an operating cycle for the home appliance in response to a signal received on the trigger port that indicates availability of an alternative resource.06-23-2011
20110240060VARIABLE SPRAY-PATTERN IN WATER-USING CLEANING APPLIANCES - A dishwasher including a variable spray device operable to spray a liquid into a washing container of the dishwasher, the variable spray device, and a method thereof. The variable spray device may be structured to include a chamber for receiving the liquid therein, such as a dishwashing liquid or water, and a liquid deflector disposed in the chamber. The liquid deflector may have a geometrically shaped perimeter, for example, a conical shape, that allows for the generation of a centrifugal force within the chamber used in directing the spray of the liquid into the washing container. By varying a force or pressure of the liquid as it interacts with the liquid deflector in the chamber, variable spray patterns may be generated.10-06-2011
20110265827DISHWASHER WITH IMPROVED CLEANING EFFECT - A dishwasher, wherein a duct system has a function describing a pressure difference in dependence on the rotational speed of the circulating pump and having a lower rotational speed range in which the pressure difference changes at most in proportion to the rotational speed of the circulating pump and an upper rotational speed range in which the pressure difference changes more than in proportion to the rotational speed of the circulating pump; and wherein the control device has a first rinsing program in which the circulating pump is operated at a normal cleaning rotational speed for normal cleaning of the rinsing stock and a second rinsing program in which the circulating pump is operated at an intensive cleaning rotational speed higher than the normal cleaning rotational speed and lying in the upper rotational speed range for intensive cleaning of the rinsing stock.11-03-2011
20120230049HOUSEHOLD APPLIANCE INCLUDING INFORMATION LIGHT DEVICE - A household appliance including an information light device that allows a user of the household appliance to determine when the household device is in operation, and a method thereof. The information light device may include a light guide structured to indicate an operating status of the household appliance. The light guide may be disposed at a lower portion of the household appliance, and embodied as a wave guide where at least part of the light that exits the light guide is guided in a direction that is perpendicular to the light guide and onto a floor where the household appliance is disposed.09-13-2012

Rance A. Winkler, Atlanta, GA US

Patent application numberDescriptionPublished
20120116146Multi-lumen instrument for providing radiation to a body cavity - A brachytherapy system for treating metastases on and around a patient's spinous process is provided. The device generally includes a catheter member having a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of a patient's spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members, and optionally can include at least one centering mechanism disposed within each of the first and second anchoring elements.05-10-2012

Randal J. Winkler, Overland Park, KS US

Patent application numberDescriptionPublished
20080264076System and method for recovering and liquefying boil-off gas - A system and process to re-liquefy boil-off liquid natural gas in varied amounts by a process using a screw compressor having an effective compression range from about 10 to about 100 percent of its rated capacity.10-30-2008

Sandra L. Winkler, Allen Park, MI US

Patent application numberDescriptionPublished
20130232027Fleet Purchase Planner - A system and method for generating a vehicle fleet configuration for purchase, replacement, and/or deployment of vehicles include an input device configured to receive user input indicative of a number of vehicles to purchase and at least one fleet operational parameter target. A computer in communication with the input device and a database having emissions and fuel economy information for a plurality of available vehicle models and associated powertrain configurations is configured to generate a recommended number of vehicles for each of the available vehicle models with associated powertrain configurations to satisfy the number of vehicles to purchase, wherein the operational parameters associated with the number of vehicles satisfy at least one fleet operational parameter target, which may include one of minimizing cost or minimizing emissions, for example.09-05-2013

Shenlei Elizabeth Winkler, New York, NY US

Patent application numberDescriptionPublished
20090106669METHOD AND APPARATUS FOR VIRTUAL WORLD BASED PRODUCT DESIGN - Systems and methods are provided for conducting the entire development process of new products, such as clothing or fashion designs, from conception through production in a virtual world. The virtual world is a multi-user three-dimensional persistent interactive graphical environment in which a plurality of avatars can interact as if interacting in the physical world to develop a new product. The avatars represent actual individuals that are contributors to the product development process. Each avatar can communicate with other avatars, can interact with and modify the graphical environment and can manipulate three-dimensional objects within the graphical environment for purposes of demonstration, explanation or review. Databases containing the necessary elements for product design are provided and are accessible by the avatars within the graphical environment.04-23-2009

Suzanne T. Winkler, Sellersburg, IN US

Patent application numberDescriptionPublished
20120191593PROVIDING AN INTERFACE TO LOAN INFORMATION - In an exemplary embodiment, a method includes receiving a request from a client access module to access loan information from a loan system, wherein the request is initiated by a selected one of a client and a participant. A processor determines whether the request is initiated by the participant and retrieves loan information associated with the request. The retrieved loan information is communicated through the client access module to the participant if the request is initiated by the participant.07-26-2012

Thomas D. Winkler, Fenton, MO US

Patent application numberDescriptionPublished
20100172543Multiple object speed tracking system - A multiple object speed tracking system that can provide data related to the rate of travel of each object in a set of multiple objects as each object is traveling either toward or away from a predetermined point.07-08-2010

Timothy P. Winkler, Skokie, IL US

Patent application numberDescriptionPublished
20130238716PROVIDING A COLLABORATIVE STATUS MESSAGE IN AN INSTANT MESSAGING SYSTEM - A method, system and computer program product for providing a collaborative status message in an instant messaging system. Instant Messaging (“IM”) users that belong to a group are identified. A collaborative status message (e.g., “In Meeting with User 2 and User 3”) is generated that specifies the IM users of the group (e.g., User 2 and User 3) that are participating in an event (e.g., meeting) with an IM user upon the event occurring. The collaborative status message is broadcasted to other IM users. In this manner, more detailed information can be provided to other IM users regarding the status of the IM user in question.09-12-2013
20130238737PROVIDING A COLLABORATIVE STATUS MESSAGE IN AN INSTANT MESSAGING SYSTEM - A method, system and computer program product for providing a collaborative status message in an instant messaging system. Instant Messaging (“IM”) users that belong to a group are identified. A collaborative status message (e.g., “In Meeting with User 2 and User 3”) is generated that specifies the IM users of the group (e.g., User 2 and User 3) that are participating in an event (e.g., meeting) with an IM user upon the event occurring. The collaborative status message is broadcasted to other IM users. In this manner, more detailed information can be provided to other IM users regarding the status of the IM user in question.09-12-2013
20130304899VIRTUAL MACHINE ALLOCATION AT PHYSICAL RESOURCES - Communications between virtual machines are monitored to identify virtual machines that have an affinity with each other, such as where the virtual machines have greater than a threshold of communication between each other. An affinity table tracks virtual machines having an affinity relationship and is referenced upon start-up or migration of a virtual machine so that a starting-up or migrating virtual machine will run on the same processing resource as virtual machines with which it has an affinity relationship.11-14-2013
20140379666Error Correction in Tables Using Discovered Functional Dependencies - Mechanisms are provided for performing tabular data correction in a document. Tabular data is received and analyzed to identify at least one portion of the tabular data having an erroneous/missing data value. A functional dependency of the at least one portion of the tabular data on one or more other portions of the tabular data is determined. A correct data value for the erroneous or missing data value of the at least one portion of the tabular data is determined based on the functional dependency of the at least one portion. In addition, the tabular data is modified to replace the erroneous or missing data value with the correct data value and thereby generate a modified table data. A processing operation is then performed on the modified table data to generate a resulting output.12-25-2014
20150046785Error Correction in Tables Using Discovered Functional Dependencies - Mechanisms are provided for performing tabular data correction in a document. Tabular data is received and analyzed to identify at least one portion of the tabular data having an erroneous/missing data value. A functional dependency of the at least one portion of the tabular data on one or more other portions of the tabular data is determined. A correct data value for the erroneous or missing data value of the at least one portion of the tabular data is determined based on the functional dependency of the at least one portion. In addition, the tabular data is modified to replace the erroneous or missing data value with the correct data value and thereby generate a modified table data. A processing operation is then performed on the modified table data to generate a resulting output.02-12-2015

Patent applications by Timothy P. Winkler, Skokie, IL US

Tim P. Winkler, Southbury, CT US

Patent application numberDescriptionPublished
20110157090MORPHING TOUCHSCREEN KEYBOARD INTERFACE - Embodiments of the present invention address deficiencies of the art in respect to touch interfaces and provide a novel and non-obvious method, system and computer program product for generating touch interface displays. In one embodiment of the invention, a computer-implemented method for generating touch interface displays at a communication device with a touch interface includes initiating a set of calibration exercises, providing a set of instructions to a user of the communication device, receiving calibration data at the touch interface, analyzing the received calibration data to determine if the calibration is complete, repeating said providing and receiving steps until the calibration is complete and generating a touch interface display based on the received calibration data. The computer-implemented method can further include receiving use data for each key touch of the touch interface, defining a set of averages over time for finger skin touch area, finger size data and finger position and automatically resizing, reshaping and repositioning at least one key of the touch interface display based on the defined set of averages.06-30-2011
20110161329TAG CLOUD BUDDY LIST FOR MESSAGING CONTACTS - Embodiments of the present invention provide a method, system and computer program product for tag cloud buddy lists. In an embodiment of the invention, a method for tag cloud buddy list management can be provided. The method can include loading a list of contacts in a messaging system executing in memory by a processor of a computer, rating each of the contacts in the list according to at least one criteria, and visually emphasizing each of the contacts differently in a buddy cloud for a user interface to the messaging system according to different ratings applied to each of the contacts. Optionally, contacts with ratings failing to exceed a threshold value can be filtered from the buddy cloud. In this regard, the threshold value can be selected with a slider control displayed in the messaging system.06-30-2011

Wade Winkler, Dallas, TX US

Patent application numberDescriptionPublished
20100041742RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.02-18-2010
20100152212PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES - The preQ1 riboswitch is a target for antibiotics and other small molecule therapies. The preQ1riboswitch and portions thereof can be used to regulate the expression or function of RNA molecules and other elements and molecules. The preQ1 riboswitch and portions thereof can be used in a variety of other methods to, for example, identify or detect compounds. Compounds can be used to stimulate, active, inhibit and/or inactivate the preQ1 riboswitch. The preQ1 riboswitch and portions thereof, both alone and in combination with other nucleic acids, can be used in a variety of constructs and RNA molecules and can be encoded by nucleic acids.06-17-2010
20100190244RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen—turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.07-29-2010
20110150854RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen—turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.06-23-2011
20110151471RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen—turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.06-23-2011
20110152213RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen—turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.06-23-2011
20110152215RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen—turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.06-23-2011
20130012527PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES01-10-2013

Patent applications by Wade Winkler, Dallas, TX US

Wayne F. Winkler, De Pere, WI US

Patent application numberDescriptionPublished
20120181237Screen Basket Optimized For Removal Of Stickies From Adhesives-Contaminated Recyclable Fiber - A screen structure which is unusually effective at removing stickies from recyclable fiber but is tolerant of substantial swings in throughput which result in variations in the flow velocity through the screen-slot velocity. One example of the screen structure is created by forming a very large number of similarly shaped vanes then locking them into a ring structure to form a cylindrical screen basket but equivalent surface configurations can also be formed into sheet stock.07-19-2012
20130299104Screen Basket Optimized For Removal Of Stickies From Adhesives-Contaminated Recyclable Fiber - A screen structure which is unusually effective at removing stickies from recyclable fiber but is tolerant of substantial swings in throughput which result in variations in the flow velocity through the screen—slot velocity. One example of the screen structure is created by forming a very large number of similarly shaped vanes then locking them into a ring structure to form a cylindrical screen basket but equivalent surface configurations can also be formed into sheet stock.11-14-2013

Wendi J. Winkler, Minnespolis, MN US

Patent application numberDescriptionPublished
20110064916METHOD OF MAKING ADHESIVE ARTICLE - Methods of making cut adhesive articles are described. The methods involve: providing a crosslinked pressure sensitive adhesive layer disposed on a substrate, embossing a surface of the crosslinked pressure sensitive adhesive layer to form a microstructured crosslinked pressure sensitive adhesive layer having a microstructured adhesive surface, and die cutting the microstructured crosslinked pressure sensitive adhesive layer.03-17-2011

Wendi J. Winkler, Minnepolis, MN US

Patent application numberDescriptionPublished
20110134623LIGHTGUIDE HAVING A VISCOELASTIC LAYER FOR MANAGING LIGHT - Disclosed herein is an optical device including a light source and an optical article. The optical article includes a lightguide and a viscoelastic layer disposed on the lightguide. Light emitted by the light source enters the lightguide and is transported within the lightguide by total internal reflection. The viscoelastic layer manages light, for example, at least about 50%, or less than about 10%, of light that enters the lightguide may be extracted. The optical device can be used in a variety of constructions for signs, markings, display devices, keypad assemblies, tail light assemblies and illumination devices.06-09-2011
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