Patent application number | Description | Published |
20080227749 | CARRAGEENAN-BASED FORMULATIONS AND ASSOCIATED METHODS OF USE - A method is provided for treating a female individual who suffers from or is prone to dyspareunia. The method involves vaginal and/or vulvar administration of a formulation comprising a therapeutically effective amount of a carrageenan and a pharmaceutically acceptable aqueous carrier. In addition, a carrageenan-based formulation is provided as a new composition of matter. Packaged kits for an individual to use in the administration of a carrageenan-based formulation as provided as well. | 09-18-2008 |
20080255093 | COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS - The present invention is drawn to combinations of pharmaceutical agents having similar chemical and/or pharmacological properties, wherein the combinations maximize the therapeutic effect of the drug while minimizing their adverse effects. The methods and compositions of the invention are particularly useful in the treatment of obesity and related conditions which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) or bupropion in combination with an anti-epileptic agent (e.g., topiramate, zonisamide), CB1 antagonists (e.g., rimonabant), or a 5HT | 10-16-2008 |
20080312163 | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors - This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology. | 12-18-2008 |
20090304785 | ESCALATING DOSING REGIMEN FOR EFFECTING WEIGHT LOSS AND TREATING OBESITY - The present invention is drawn to novel topiramate compositions as well as methods for effecting weight loss, e.g., in the treatment of obesity and related conditions, including conditions associated with and/or caused by obesity per se. The present invention features an escalating dosing regimen adapted for the administration of topiramate and optionally a sympathomimetic agent such as phentermine or bupropion, in the treatment of obesity and related conditions. | 12-10-2009 |
20090304789 | NOVEL TOPIRAMATE COMPOSITIONS AND AN ESCALATING DOSING STRATEGY FOR TREATING OBESITY AND RELATED DISORDERS - The present invention is drawn to novel topiramate compositions as well as methods for treating obesity and related conditions, including conditions associated with and/or caused by obesity per se. The present invention also features a pharmaceutical composition that includes, e.g., topiramate alone or in combination with a sympathomimetic agent and a novel escalating dosing strategy for administering such compositions. | 12-10-2009 |
20100087402 | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders - The present invention relates to the treatment of estrogen-dependent hyperproliferative uterine disorders including endometriosis, uterine fibroids, endometrial hyperplasia, uterine cancer, and their related symptoms by intravaginally administering at least two active agents selected from an aromatase inhibitor, an antiinflammatory agent, and a uterine-selective estrogen receptor antagonist. This combination therapy reduces local estrogen production, blocks local estrogen action, and suppresses inflammation locally, resulting in starvation of the estrogen-dependent diseased tissues, relief of related symptoms, and retardation of disease progression. Intravaginal delivery maximizes local inhibition of estrogen production without significantly affecting systemic circulating estrogen levels. This results in enhanced clinical efficacy and reduced side effects. | 04-08-2010 |
20100215739 | LOW DOSE TOPIRAMATE / PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF - A method for effecting weight loss by administering a combination of topiramate and phentermine is provided. The phentermine is generally administered in immediate release form, in a daily dose in the range of 2 mg to 8 mg, in combination with a daily dose of topiramate selected to prevent the loss of effectiveness of phentermine alone. Methods for treating obesity, conditions associated with obesity, and other indications are also provided, as are compositions and dosage forms containing low doses of phentermine and topiramate, e.g., 3.75 mg phentermine and 23 mg topiramate. | 08-26-2010 |
20110224196 | TREATMENT OF OBSTRUCTIVE SLEEP APNEA SYNDROME WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ADDITIONAL ACTIVE AGENT - This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (OSAS). Treatment of OSAS is effected by administering a carbonic anhydrase inhibitor to the patient in combination with at least one additional active agent. Examples of additional active agents include modafinil, eszopiclone, zolpidem, zaleplon, and phentermine. | 09-15-2011 |
20110262535 | Low Dose Topiramate / Phentermine Composition and Methods of Use Thereof - A method for effecting weight loss by administering a combination of topiramate and phentermine is provided. The phentermine is generally administered in immediate release form, in a daily dose in the range of 2 mg to 8 mg, in combination with a daily dose of topiramate selected to prevent the loss of effectiveness of phentermine alone. Methods for treating obesity, conditions associated with obesity, and other indications are also provided, as are compositions and dosage forms containing low doses of phentermine and topiramate, e.g., 3.75 mg phentermine and 23 mg topiramate. | 10-27-2011 |
20120196881 | Treatment Of Pulmonary Hypertension With Carbonic Anhydrase Inhibitors - This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology. | 08-02-2012 |
20140037723 | Low Dose Topiramate/Phentermine Composition And Methods Of Use Thereof - A method for effecting weight loss by administering a combination of topiramate and phentermine is provided. The phentermine is generally administered in immediate release form, in a daily dose in the range of 2 mg to 8 mg, in combination with a daily dose of topiramate selected to prevent the loss of effectiveness of phentermine alone. Methods for treating obesity, conditions associated with obesity, and other indications are also provided, as are compositions and dosage forms containing low doses of phentermine and topiramate, e.g., 3.75 mg phentermine and 23 mg topiramate. | 02-06-2014 |
20140080794 | Methods and Compositions for the Treatment of Estrogen-Dependent Hyperproliferative Uterine Disorders - The present invention relates to the treatment of estrogen-dependent hyperproliferative uterine disorders including endometriosis, uterine fibroids, endometrial hyperplasia, uterine cancer, and their related symptoms by intravaginally administering at least two active agents selected from an aromatase inhibitor, an antiinflammatory agent, and a uterine-selective estrogen receptor antagonist. This combination therapy reduces local estrogen production, blocks local estrogen action, and suppresses inflammation locally, resulting in starvation of the estrogen-dependent diseased tissues, relief of related symptoms, and retardation of disease progression. Intravaginal delivery maximizes local inhibition of estrogen production without significantly affecting systemic circulating estrogen levels. This results in enhanced clinical efficacy and reduced side effects. | 03-20-2014 |
20140088162 | Treatment of Pulmonary Hypertension with Carbonic Anhydrase Inhibitors - This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology. | 03-27-2014 |
20140094511 | Treatment of Obstructive Sleep Apnea Syndrome with a Combination of a Carbonic Anhydrase Inhibitor and an Additional Active Agent - This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (OSAS). Treatment of OSAS is effected by administering a carbonic anhydrase inhibitor to the patient in combination with at least one additional active agent. Examples of additional active agents include modafinil, eszopiclone, zolpidem, zaleplon, and phentermine. | 04-03-2014 |
20140187623 | Escalating Dosing Regimen For Effecting Weight Loss And Treating Obesity - The present invention is drawn to novel topiramate compositions as well as methods for effecting weight loss, e.g., in the treatment of obesity and related conditions, including conditions associated with and/or caused by obesity per se. The present invention features an escalating dosing regimen adapted for the administration of topiramate and optionally a sympathomimetic agent such as phentermine or bupropion, in the treatment of obesity and related conditions. | 07-03-2014 |
Patent application number | Description | Published |
20090322266 | Systems and Methods for Controlling a DC Motor - Various systems and methods for controlling DC motors are disclosed herein. For example, one method provides for controlling a polyphase, brushless DC motor. The method includes providing a DC motor that has a plurality of phases. Such a DC motor operates by inducing a current in the plurality of phases in accordance with a plurality of commutation states. In the example, six commutation states are discussed, but fewer than or more than six commutation states may exist. The method further includes initializing a count, inducing a current in the plurality of phases in accordance with a first commutation state, and incrementing the count until the current achieves a threshold in the first commutation state. Then, a current is induced in the plurality of phases in accordance with a second commutation state, and the count is decremented until the current achieves the threshold in the second commutation state. The sign bit of the count is stored, and a desired initial commutation state is determined based at least in part on the sign bit of the count. | 12-31-2009 |
20120063025 | HIGH SPEED WRITER - An apparatus comprising a control circuit, a driver circuit and a write head. The control circuit may be configured to generate a plurality of control signals in response to a data input signal. The driver circuit may be configured to generate a differential write control signal in response to the plurality of control signals. The driver circuit may receive the plurality of control signals through a flexible bus. The driver circuit may be located remotely from the control circuit. The write head may be configured to write information by physically moving above one of a plurality of tracks on a disk in response to the write control signal. The driver circuit may be configured to move along with the write head. | 03-15-2012 |
20120275278 | Systems and Methods for Data Write Loopback Based Timing Control - Various embodiments of the present invention provide systems and methods for data writing. As an example, a heat assisted loopback circuit is discussed that includes: a read circuit, a magnetic write circuit, a heat write circuit, and a loopback circuit. The read circuit is operable to sense data from a storage medium, and to provide the sensed data as a read output. The magnetic write circuit is operable to provide a write output corresponding to an excitation signal of a write head. The heat write circuit is operable to provide a heat output corresponding to an excitation signal of a heat source. The loopback circuit is operable to selectively couple a derivative of the heat output to the read output and to selectively couple a derivative of the write output to the read output. | 11-01-2012 |
20120275279 | Systems and Methods for Laser Write Control - Various embodiments of the present invention provide systems and methods for data writing. As an example, a heat assisted data write circuit is discussed that includes a heat write output, a magnetic write output, and a variable phase shift circuit operable to modify a relative phase of the heat write output to the magnetic write output. | 11-01-2012 |
20130128375 | Magnetic Recording System With Multi-Level Write Current - Various embodiments of the present invention provide apparatuses, systems and methods for magnetic recording with a multi-level write current waveform. For example, an apparatus for magnetic recording with a multi-level write current waveform is disclosed that includes a pattern detection circuit operable to detect patterns in data to be written by the magnetic write head and to yield a pattern indicator signal, and a write driver operable to generate the multi-level write current waveform for the magnetic write head. At least one electrical characteristic of the multi-level write current waveform is based upon the patterns detected by the pattern detection circuit. | 05-23-2013 |
20140022876 | Systems and Methods for Data Write Loopback Based Timing Control - Various embodiments of the present invention provide systems and methods for data writing. As an example, a heat assisted loopback circuit is discussed that includes: a read circuit, a magnetic write circuit, a heat write circuit, and a loopback circuit. The read circuit is operable to sense data from a storage medium, and to provide the sensed data as a read output. The magnetic write circuit is operable to provide a write output corresponding to an excitation signal of a write head. The heat write circuit is operable to provide a heat output corresponding to an excitation signal of a heat source. The loopback circuit is operable to selectively couple a derivative of the heat output to the read output and to selectively couple a derivative of the write output to the read output. | 01-23-2014 |
20140104716 | PREAMPLIFIER-TO-CHANNEL COMMUNICATION IN A STORAGE DEVICE - An apparatus comprising a preamplifier, a channel, and a controller. The preamplifier may be configured to read/write data to a drive with a read/write head, in response to (i) a plurality of digital control signals multiplexed to be sent/received over a first bus and (ii) one or more analog data signals sent/received over a second bus. The channel may be configured to (i) connect to the first and second bus, and (ii) send/receive the plurality of digital control signals through (a) a plurality of interconnects and (b) the first bus. The controller may be configured to send/receive the digital control signals over the interconnects. The apparatus may be configured to (i) read/write the analog data signals to the drive and (ii) generate the digital control signals, in response to one or more input/output requests received from a drive interface. | 04-17-2014 |
20140118966 | Low Inductance Flex Bond with Low Thermal Resistance - A electronic circuit with low inductance connections is disclosed. The electronic circuit includes a ground plane and a flex circuit. The flex circuit having a first surface generally facing the ground plane and a second surface opposite to the first surface. The flex circuit also having a flexible bridge defined thereof. The electronic circuit further includes a first electronic device communicatively coupled to the second surface of the flex circuit, a second electronic device communicatively coupled to the second surface of the flex circuit, and at least one conductive trace defined on the second surface of the flex circuit and extending along the flexible bridge. One end of the at least one conductive trace is configured for receiving an outbound current from the first electronic device and another end of the at least one conductive trace is communicatively coupled to the second electronic device through a vertical interconnect access. | 05-01-2014 |
20140119164 | Laser Power Control in a Heat-Assisted Magnetic Recording System - A heat-assisted magnetic recording system may include, but is not limited to: at least one magnetic recording read/write head; at least one laser diode configured to illuminate at least a portion of at least one magnetic recording medium; at least one laser power level sensor configured to detect a power level of the at least one laser diode; and a controller configured to modify one or more power level settings associated with the at least one laser diode in response to one or more output signals of the at least one laser power level sensor. | 05-01-2014 |
20140119427 | Method and Apparatus for High Density Pulse Density Modulation - A method and system for high density pulse density modulation is disclosed. In accordance with the present disclosure, a modulation function is split in to two band limited streams using a complementary pair of non-linear functions. More specifically, one bitstream definition contains the peaks of the original function while the other bitstream contains a soft clipping version of the original bitstream. The bitstreams are applied to a pair of switching amplifiers, and the bitstreams can be combined again to reconstruct the original function. The method in accordance with the present disclosure limits the amount of input power necessary to achieve higher output power, lowers operating voltage and improves power amplifier efficiency. | 05-01-2014 |
20140119470 | Digital Radio Frequency Clocking Methods - A method and system for synchronous transfer of bitstream data between a power-driver chip and a digital signal processing chip in a digital radio frequency transmit system is disclosed. A master phase-locked-loop located in the power-driver chip is utilized to provide master clocking control for the digital radio frequency transmit system. Furthermore, the clocking method and system is configurable to secure precise carrier frequency positioning of a digitally-generated radio frequency signal based on predetermined chip frequencies unrelated to the carrier frequency, assuring low bitstream phase noise at the output of the power driver chip. | 05-01-2014 |
20140159991 | SWITCHING POWER AMPLIFIER SYSTEM FOR MULTI-PATH SIGNAL INTERLEAVING - A switching power amplifier for multi-path signal interleaving includes a signal splitter configured to split a multi-bit source signal from a digital source into a plurality of multi-bit signals, one or more fractional delay filters configured to delay one or more signals of the plurality of signals by a selected time, a plurality of bit-stream converters, each bit-stream converter configured to receive one of the multi-bit signals, each bit-stream converter further configured to generate a single-bit signal based on a received multi-bit signal, a plurality of switching power amplifiers, each switching power amplifier configured to receive a single-bit signal from one of the bit-stream converters, and an interleaver configured to generate an interleaved output by interleaving two or more outputs of the switching power amplifiers, wherein a sampling frequency of the interleaved output of the interleaver is greater than the selected sampling frequency of the multi-bit source signal. | 06-12-2014 |
20140168809 | TAG MULTIPLICATION VIA A PREAMPLIFIER INTERFACE - An apparatus having a controller and a preamplifier is disclosed. The controller may be configured to generate information on a serial bus coupled to a preamplifier interface. The preamplifier may be configured to (i) generate a count value in response to a clock signal synchronized to a recording medium and (ii) generate a plurality of tag signals based on the information and the count value. The tag signals may gate a read operation and a write operation of the preamplifier. | 06-19-2014 |
20140184323 | Hybrid Digital/Analog Power Amplifier - The invention may be embodied in radio frequency power amplifier (RF-PA) predriver circuits employing a hybrid analog/digital RF architecture including a resynchronizing digital-to-analog convertor to drive an efficient high-power output stage suitable for driving standard high power amplifier (HPA) output devices. The hybrid analog/digital RF architecture retains the advantages of high digital content integration found in conventional Class-S architecture, while relaxing the performance requirements on the output transistors and on the bitstream generator. The resulting predriver circuit combines the VLSI integration benefits of digital designs with the extensibility to arbitrary output power levels characteristic of analog designs. The hybrid analog/digital driving circuit is well suited for use with analog and Class-S HPAs used in wireless communication systems, such as the Doherty type HPA. | 07-03-2014 |
20140191801 | BICMOS GATE DRIVER FOR CLASS-S RADIO FREQUENCY POWER AMPLIFIER - The invention may be embodied in a resynchronizing, push-pull drive circuit for driving the gate electrodes of a digital Class-S Radio Frequency Power Amplifier (RF-PA). A binary bitstream received from a bitstream generator, such as a sigma-delta modulator, Viterbi-based optimal-bit-pattern modulator sigma-delta, or other suitable modulator, is resynchronized to a low-jitter master clock, then converted to fast-rise, high-swing complementary digital signals to drive the gates of the Class-S RF-PA. The drive circuit provides a high slew-rate, large-swing, quasi-digital gate drive circuit to drive the significant gate capacitance of the RF-PA with sufficient rise times. A combination of bipolar transistor current switches and cascoded CMOS devices is employed to attain requisite performance. For example, the driving circuit is well suited for use with Class-S RF-PAs used in wireless communication systems. | 07-10-2014 |
20140266820 | INTERLEAVED MULTIPATH DIGITAL POWER AMPLIFICATION - In one embodiment, a power amplification system of a radio-frequency transmitter includes a digital signal source that provides a digital input signal to an interleaved-bit-stream generator, which outputs a digital switching signal to a switching power amplifier. The interleaved-bit-stream generator has an eight-path interleaving architecture that helps reduce the effective clock-rate requirements of the interleaved-bit-stream generator. The interleaved-bit-stream generator includes an array of fractional-delay filters for receiving the digital input signal and outputting eight fractionally delayed digital output signals to a bit-stream generation array adapted to output eight corresponding bit streams to a serializer block that interleaves and combines the eight bit-streams into the digital switching signal. The relative phases of the interleaved signals may be adjusted to achieve certain desired effects. | 09-18-2014 |
20140269978 | INTERLEAVED MULTIPATH DIGITAL POWER AMPLIFICATION - In one embodiment, a power amplification system of a radio-frequency transmitter includes a digital signal source that provides a digital input signal to an interleaved-bit-stream generator, which outputs a digital switching signal to a switching power amplifier. The interleaved-bit-stream generator has an eight-path interleaving architecture that helps reduce the effective clock-rate requirements of the interleaved-bit-stream generator. The interleaved-bit-stream generator includes an array of fractional-delay filters for receiving the digital input signal and outputting eight fractionally delayed digital output signals to a bit-stream generation array adapted to output eight corresponding bit streams to a serializer block that interleaves and combines the eight bit-streams into the digital switching signal. The relative phases of the interleaved signals may be adjusted to achieve certain desired effects. | 09-18-2014 |
20150015329 | RADIO FREQUENCY COMPOSITE CLASS-S POWER AMPLIFIER HAVING DISCRETE POWER CONTROL - A composite amplifier providing digitally selectable amplification includes a plurality of channels and a combiner. Each of the channels includes a digitally controllable selector, a Class-S power amplifier, and bandpass filter. The digitally controllable selector selectively couples a digital bitstream to the amplifier. The amplifier receives the digital bitstream and provides an amplified signal. The bandpass filter generates a filtered signal as a function of the amplified signal. The combiner couples filtered signals provided by the channels to form a composite output signal. A method of providing digitally selectable amplification includes steps of: selectively coupling a digital bitstream to a plurality of channels in the amplifier; amplifying the digital bitstream to provide an amplified signal associated with a corresponding one of the channels; filtering amplified signals associated with the channels to provide corresponding filtered signals; and combining the filtered signals to generate a composite output signal. | 01-15-2015 |
20150042403 | High-Voltage Voltage-Switched Class-S Amplifier - A voltage-switched class-S amplifier circuit includes an output stage configured to receive at least one control signal and operative to generate an output signal as a function of the at least one control signal. The amplifier circuit further includes a driver circuit coupled with the output stage. The driver circuit is configured to receive an input bit stream signal and is operative to generate the control signal as a function of the input bit stream signal in such a manner that a common mode component is eliminated from the control signal. | 02-12-2015 |
20150062737 | Adaptive Pattern Detection for Pattern-Dependent Write Current Control in a Magnetic Recording System - The disclosure is directed to a system and method of a system and method for determining fundamental bit cell duration of a data record, which can be used for pattern-dependent write (PDW) current control. According to various embodiments of the disclosure, at least a first portion of a data record is fed through a plurality of delay units. A binary output of each delay unit is stored in at least one register when the delay units have received the first portion of the data record. The register contents are then decoded to determine fundamental bit cell duration of the data record based upon the stored binary outputs. | 03-05-2015 |
20150074501 | Cascaded Viterbi Bitstream Generator - A bitstream generator includes at least first and second bitstream generator stages connected in a cascaded arrangement. The first bitstream generator stage includes a first adder which receives an input signal and generates a first error signal indicative of a difference between the input signal and a first bitstream candidate representing a closest approximation to the input signal among multiple bitstream candidates generated by the first bitstream generator stage. The second bitstream generator stage includes a second adder which receives the first error signal and generates a second error signal indicative of a difference between the first error signal and a second bitstream candidate representing a closest approximation to the input signal among multiple bitstream candidates generated by the second bitstream generator stage. A third adder in the bitstream generator receives the first and second bitstream candidates and generates an output signal more closely approximating the input signal. | 03-12-2015 |