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| 20080251234 | REGENERATOR WHEEL APPARATUS - A regenerator wheel is disclosed. The regenerator wheel includes a framework, a plurality of ports disposed within the framework, with at least one port of the plurality of ports separated from another port by the framework. The regenerator wheel also includes a plurality of matrixes aligned individually with the plurality of ports. | 10-16-2008 |
| 20090000761 | REGENERATIVE HEAT EXCHANGER WITH ENERGY-STORING DRIVE SYSTEM - A regenerative heat exchanger having an energy-storing drive system includes a high heat capacity matrix rotable about an axis and a drive system that is in operable communication with the high heat capacity matrix and is capable of rotating the high heat capacity matrix about the axis. An energy-storage mechanism is in operable communication with the drive system. The energy-storage mechanism is capable of controlling an acceleration and/or deceleration of rotation of the high heat capacity matrix thus reducing an amount of energy required to be input into the drive system to rotate the high heat capacity matrix. | 01-01-2009 |
| 20090000762 | BRUSH-SEAL AND MATRIX FOR REGENERATIVE HEAT EXCHANGER, AND METHOD OF ADJUSTING SAME - Disclosed is a regenerative heat exchanger including a brush-seal configuration to prevent mixing of fluid flows. The regenerative heat exchanger includes a regenerator, and at least two conduits, each conduit having a matrix end abutting a face of the regenerator matrix. The at least two conduits carrying at least two fluid flows, the fluid flows which pass through the regenerator matrix. The regenerative heat exchanger includes a plurality of brush-seals, each brush-seal located at a matrix end of each conduit without contacting the matrix, thereby sealing around a periphery of each conduit to prevent mixing of fluid flows. Also disclosed is a method for establishing a minimal gap between a regenerator matrix of a regenerative heat exchanger and a plurality of brush-seals. | 01-01-2009 |
| 20120018955 | INTERMITTENT SEALING DEVICE AND METHOD - An exemplary embodiment disclosed herein relates to an articulatable sealing device. The device includes a plurality of seal elements each of which is urgable against a seal-surface, a fixing member tightenable about a perimeter of the seal elements, and a retractor in operable communication with the plurality of seal elements and able to move the plurality of seal elements in a desired direction. | 01-26-2012 |
| 20130015666 | HORIZONTAL-AXIS WIND TURBINE - Improved wind turbine. The turbine includes a rotor supporting a plurality of blades for receiving wind, and means are provided for supporting magnets or high-permeability iron to rotate with the blades and located at the periphery of the blade tips. Stator stricture is located proximate to the blade tips to interact with the magnets or iron to generate electricity. | 01-17-2013 |
| 20130302163 | METHOD AND APPARATUS FOR CONNECTING TURBINE ROTORS - Connecting rotors in rotary machines, particularly turbines, is generally described. Some aspects of the invention provide for a simplified attachment rotors to each other and/or other components of a turbine assembly, such as, drive shaft, using friction fit. | 11-14-2013 |
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| 20130059784 | COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES - The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine. | 03-07-2013 |
| 20130190244 | METHODS FOR PERFORMING A CORONARY ARTERY BYPASS GRAFT PROCEDURE - The invention provides methods of treating an obstructive coronary artery disease in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof and performing a coronary artery bypass graft procedure on the subject. | 07-25-2013 |
| 20130195837 | METHODS FOR THE PREVENTION OR TREATMENT OF VESSEL OCCLUSION INJURY - This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof, wherein the peptide is D-Arg-2 6-Dmt-Lys-Phe-NH2 (SS-31). | 08-01-2013 |
| 20130196921 | METHODS FOR THE PREVENTION OR TREATMENT OF NO-REFLOW FOLLOWING ISCHEMIA/REPERFUSION INJURY - The invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods provide administering aromatic-cationic peptides in effective amounts to prevent or treat an anatomic zone of no re-flow in mammalian subjects. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 08-01-2013 |
| 20130303436 | PEPTIDE THERAPEUTICS AND METHODS FOR USING SAME - Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of GLP-1, and/or naturally or artificially occurring variants or analogues of GLP-1, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as D-Arg-2′6′-Dmt-Lys-Phe-NH | 11-14-2013 |
| 20140093897 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance. | 04-03-2014 |
| 20140235529 | AROMATIC-CATIONIC PEPTIDES AND METHODS FOR USING SAME - The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis. The methods include administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 08-21-2014 |
| 20140294796 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant. | 10-02-2014 |
| 20140341879 | METHODS FOR THE PREVENTION OR TREATMENT OF VESSEL OCCLUSION INJURY - This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof wherein the peptide is D-Arg-26-Dmt-Lys-Phe-NH2 (SS-31). | 11-20-2014 |
| 20140349941 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, apoptosis inhibition and electrical conductance. | 11-27-2014 |
| 20140364370 | COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES - The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine. | 12-11-2014 |
| 20140378396 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, apoptosis inhibition and electrical conductance. | 12-25-2014 |
| 20150018288 | METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS - The disclosure provides methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. More specifically, the disclosure provides a composition for preventing, treating, or ameliorating the symptoms of diabetic macular edema in a mammalian subject in need thereof, comprising: a therapeutically effective amount of a peptide D-Arg-2′6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof. | 01-15-2015 |
| 20150087595 | METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT NEUROPATHY - The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition. | 03-26-2015 |
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| 20080243981 | Method and apparatus for accelerating processing of adaptive finite impulse response filtering - Finite impulse response filtering is achieved by broadcasting to at least one compute unit an instruction having a plurality of data samples, a conditional field associated with each compute unit, and a set of operator values for operating on each data sample; providing a function of each the data sample in accordance with an associated set of operator values identified by the conditional field; and combining the functions to obtain an intermediate finite impulse response of the data samples. | 10-02-2008 |
| 20080244237 | Compute unit with an internal bit FIFO circuit - A compute unit with an internal bit FIFO circuit includes at least one data register, a lookup table, a configuration register including FIFO base address, length and read/write mode fields for configuring a portion of the lookup table as a bit FIFO circuit and a read/write pointer register responsive to an instruction having a lookup table identification field, length of bits field and register extract/deposit field for selectively transferring in a single cycle between the FIFO circuit and the data register a bit field of specified length. | 10-02-2008 |
| 20080258947 | Programmable compute system for executing an H.264 binary decode symbol instruction - A compute system for executing an h.264 binary decode symbol instruction including a first compute unit having a range normalization circuit and an rLPS update circuit, and operating in a first mode responsive to current rLPS, range, value and current context to generate the next normalized range and next rLPS for the current context; a second compute unit including a value update circuit, a context update circuit, and value normalization circuit responsive to current rLPS, range value and current context to obtain the output bit, normalized value and the updated current context; and a third compute unit or said first compute unit operating in a second mode including a range circuit and a next context rLPS circuit responsive to rLPS range, value and next context to obtain a next context rLPS value. | 10-23-2008 |
| 20090089649 | Programmable compute unit with internal register and bit FIFO for executing Viterbi code - A programmable compute unit with an internal register with a bit FIFO for executing Viterbi code is configured to accumulate in the forward path the best-path to each state in an internal register and store the survivor trace back information bit for each state in each stage in a bit FIFO; and in the trace back, selecting the optimal best-path through the Viterbi trellis by tracing through the bit trace back information survivor bits beginning with the survivor bit of the last stage path; and generating in response to the Viterbi constrain length and a current bit FIFO address, the next bit FIFO address and decoded output bit for the next previous stage. | 04-02-2009 |
| 20090327378 | Instruction-Based Parallel Median Filtering - An instruction-based parallel median filtering processor and method sorts in parallel each combination of pairs of inputs into greater and lesser values; determines from that sorting the minimum, maximum and median filter values of the inputs; processes one of those values and provides the processed value as an input; and applies an instruction for providing one of the values to the processing step, and at least one other instruction for enabling indication of at least one of the maximum, minimum, median filter values. | 12-31-2009 |
| 20110296145 | PIPELINED DIGITAL SIGNAL PROCESSOR - Reducing pipeline stall between a compute unit and address unit in a processor can be accomplished by computing results in a compute unit in response to instructions of an algorithm; storing in a local random access memory array in a compute unit predetermined sets of functions, related to the computed results for predetermined sets of instructions of the algorithm; and providing within the compute unit direct mapping of computed results to related function. | 12-01-2011 |
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| 20130009100 | SYNTHESIS GAS METHOD AND APPARATUS - A method and apparatus for producing a synthesis gas product having one or more oxygen transport membrane elements thermally coupled to one or more catalytic reactors such that heat generated from the oxygen transport membrane element supplies endothermic heating requirements for steam methane reforming reactions occurring within the catalytic reactor through radiation and convention heat transfer. A hydrogen containing stream containing no more than 20 percent methane is combusted within the oxygen transport membrane element to produce the heat and a heated combustion product stream. The heated combustion product stream is combined with a reactant stream to form a combined stream that is subjected to the reforming within the catalytic reactor. The apparatus may include modules in which tubular membrane elements surround a central reactor tube. | 01-10-2013 |
| 20130009102 | OXYGEN TRANSPORT MEMBRANE SYSTEM AND METHOD FOR TRANSFERRING HEAT TO CATALYTIC/PROCESS REACTORS - A method and apparatus for producing heat used in a synthesis gas production process is provided. The disclosed method and apparatus include a plurality of tubular oxygen transport membrane elements adapted to separate oxygen from an oxygen containing stream contacting the retentate side of the membrane elements. The permeated oxygen is combusted with a hydrogen containing synthesis gas stream contacting the permeate side of the tubular oxygen transport membrane elements thereby generating a reaction product stream and radiant heat. The present method and apparatus also includes at least one catalytic reactor containing a catalyst to promote the steam reforming reaction wherein the catalytic reactor is surrounded by the plurality of tubular oxygen transport membrane elements. The view factor between the catalytic reactor and the plurality of tubular oxygen transport membrane elements radiating heat to the catalytic reactor is greater than or equal to 0.5. | 01-10-2013 |
| 20130072374 | CATALYST CONTAINING OXYGEN TRANSPORT MEMBRANE - A composite oxygen transport membrane having a dense layer, a porous support layer and an intermediate porous layer located between the dense layer and the porous support layer. Both the dense layer and the intermediate porous layer are formed from an ionic conductive material to conduct oxygen ions and an electrically conductive material to conduct electrons. The porous support layer has a high permeability, high porosity, and a microstructure exhibiting substantially uniform pore size distribution as a result of using PMMA pore forming materials or a bi-modal particle size distribution of the porous support layer materials. Catalyst particles selected to promote oxidation of a combustible substance are located in the intermediate porous layer and in the porous support adjacent to the intermediate porous layer. The catalyst particles can be formed by wicking a solution of catalyst precursors through the porous support toward the intermediate porous layer. | 03-21-2013 |
| 20130072375 | CATALYST CONTAINING OXYGEN TRANSPORT MEMBRANE - A composite oxygen transport membrane having a dense layer, a porous support layer and an intermediate porous layer located between the dense layer and the porous support layer. Both the dense layer and the intermediate porous layer are formed from an ionic conductive material to conduct oxygen ions and an electrically conductive material to conduct electrons. The porous support layer has a high permeability, high porosity, and a microstructure exhibiting substantially uniform pore size distribution as a result of using PMMA pore forming materials or a bi-modal particle size distribution of the porous support layer materials. Catalyst particles selected to promote oxidation of a combustible substance are located in the intermediate porous layer and in the porous support adjacent to the intermediate porous layer. The catalyst particles can be formed by wicking a solution of catalyst precursors through the porous support toward the intermediate porous layer. | 03-21-2013 |
| 20140056774 | OXYGEN TRANSPORT MEMBRANE SYSTEM AND METHOD FOR TRANSFERRING HEAT TO CATALYTIC/PROCESS REACTORS - A method and apparatus for producing heat used in a synthesis gas production process is provided. The disclosed method and apparatus include a plurality of tubular oxygen transport membrane elements adapted to separate oxygen from an oxygen containing stream contacting the retentate side of the membrane elements. The permeated oxygen is combusted with a hydrogen containing synthesis gas stream contacting the permeate side of the tubular oxygen transport membrane elements thereby generating a reaction product stream and radiant heat. The present method and apparatus also includes at least one catalytic reactor containing a catalyst to promote the steam reforming reaction wherein the catalytic reactor is surrounded by the plurality of tubular oxygen transport membrane elements. The view factor between the catalytic reactor and the plurality of tubular oxygen transport membrane elements radiating heat to the catalytic reactor is greater than or equal to 0.5. | 02-27-2014 |
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| 20080221628 | DEVICES AND METHODS FOR SPINE REPAIR - Surgical methods of repairing defects and deficiencies in the spine are disclosed. The methods involve delivering a single part in-situ polymerizing fluid to (i) close a weakened segment or fissure in the annulus fibrosus, (ii) strengthen the annulus, (iii) replace or augment the disc nucleus, or (iv) localize a disc prosthesis. The methods may include placing a delivery conduit adjacent to the repair site and providing a liquid tissue adhesive to bond to and repair a disc defect or deficiency | 09-11-2008 |
| 20090012462 | REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION - A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk. | 01-08-2009 |
| 20090024107 | Disc annulus closure - Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses. | 01-22-2009 |
| 20090048622 | Apparatus and methods for performing brain surgery - Less invasive surgical techniques for performing brain surgery are disclosed in which a dilating obturator and cannula assembly is inserted into brain tissue until the obturator tip and cannula are adjacent to the target tissue. The obturator is removed and surgery is performed through the cannula. In preferred embodiments the obturator and cannula are placed using image guidance techniques and systems to coordinate placement with pre-operative surgical planning. A stylet with associated image guidance may be inserted prior to insertion of the obturator and cannula assembly to guide insertion of the obturator and cannula assembly. Surgery preferably is performed using an endoscope partially inserted into the cannula with an image of the target tissue projected onto a monitor. Dilating obturator structures having a rounded or semi-spherical tip and/or an optical window for visualizing brain tissue during expansion are contemplated. | 02-19-2009 |
| 20100076486 | DISC ANNULUS CLOSURE - Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses. | 03-25-2010 |
| 20110029084 | FOAM PROSTHESIS FOR SPINAL DISC - Disclosed herein are spinal disc implants comprising a foam adapted to completely or partially replace a nucleus pulposus within a spinal disc cavity, the foam being a nonabsorbable, closed cell and having a Poisson ratio of less than 0.5. Also disclosed are methods of implanting a foam, either as an in-situ curable material or as a preformed foam. | 02-03-2011 |
| 20110306982 | DISC ANNULUS CLOSURE - Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses. | 12-15-2011 |
| 20120179176 | APPARATUS AND METHOD FOR LIMITING SURGICAL ADHESIONS - The present invention relates to a composite prosthesis including a coated mesh having at least one opening through a first surface and a second surface of the coated mesh; the coated mesh comprising a mesh and a biocompatible coating substantially surrounding each filament of the mesh, wherein the biocompatible coating is formed by coating the mesh with a polyol prepolymer and curing the prepolymer, the prepolymer comprising a polyalkylene oxide polyol end capped with isocyanate, the polyalkylene oxide polyol having from about 70% to about 95% ethylene oxide groups and the remainder propylene oxide; and a barrier material comprising a biocompatible membrane constructed and arranged to cover at least one surface of the coated mesh, wherein the barrier material comprises a biologic material. | 07-12-2012 |
| 20140107426 | APPARATUS AND METHODS FOR PERFORMING BRAIN SURGERY - Less invasive surgical techniques for performing brain surgery are disclosed in which a dilating obturator and cannula assembly is inserted into brain tissue until the obturator tip and cannula are adjacent to the target tissue. The obturator is removed and surgery is performed through the cannula. In preferred embodiments the obturator and cannula are placed using image guidance techniques and systems to coordinate placement with pre-operative surgical planning. A stylet with associated image guidance may be inserted prior to insertion of the obturator and cannula assembly to guide insertion of the obturator and cannula assembly. Surgery preferably is performed using an endoscope partially inserted into the cannula with an image of the target tissue projected onto a monitor. Dilating obturator structures having a rounded or semi-spherical tip and/or an optical window for visualizing brain tissue during expansion are contemplated. | 04-17-2014 |
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| 20090048226 | Inhibitors of caspases - The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), or interferon-γ-(“IFN-γ”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-γ production and methods for treating interleukin-1, apoptosis-, and interferon-γ-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention. | 02-19-2009 |
| 20090186394 | Crystallizable JNK complexes - The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets. | 07-23-2009 |
| 20090203702 | INHIBITORS OF p38 - The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. | 08-13-2009 |
| 20110178069 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME - The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds. | 07-21-2011 |
| 20110281878 | INHIBITORS OF p38 - The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. | 11-17-2011 |
| 20120165319 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME - The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds. | 06-28-2012 |
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| 20100234719 | Estimating Visceral Fat By Dual-Energy X-Ray Absorptiometry - A system and a method of using dual-energy absoptiometry to estimate visceral fat metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing visceral fat as well as subcutaneous fat; at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the visceral fat in the slice; and using the resulting estimates. | 09-16-2010 |
| 20100310141 | ESTIMATING RISK OF FUTURE BONE FRACTURE UTILIZING THREE-DIMENSIONAL BONE DENSITY MODEL - A novel approach for analyzing a patient's body part of interest to assess bone strength and/or risk of future fracture includes obtaining a priori information regarding the body part of interest, performing X-ray absorptiometric scans of the patient's body part of interest and collecting X-ray absorptiometry data from the scans, constructing a three-dimensional model of the patient's body part of interest, by utilizing the a priori information along with the X-ray absorptiometric data, and performing measurements of various geometric parameters on the three-dimensional model for determining geometric and structural properties. | 12-09-2010 |
| 20110235886 | VISCERAL FAT MEASUREMENT - Dual-energy absorptiometry is used to estimate visceral fat metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing visceral fat as well as subcutaneous fat, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the visceral fat in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large “abdominal” region and a smaller “abdominal cavity” region. Two boundaries of the “abdominal cavity” region are placed at positions associated with the left and right innermost extent of the abdominal muscle wall by identifying inflection of % Fat values. The regions are combined in an equation that is highly correlated with VAT measured by quantitative computed tomography in order to estimate VAT. | 09-29-2011 |
| 20110311122 | MEASURING INTRAMUSCULAR FAT - Dual-energy absorptiometry is used to estimate intramuscular adipose tissue metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing intramuscular adipose tissue as well as subcutaneous adipose tissue, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the intramuscular adipose tissue in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large region and a smaller region. The regions are combined in an equation that is highly correlated with intramuscular adipose tissue measured by quantitative computed tomography in order to estimate intramuscular adipose tissue. | 12-22-2011 |
| 20150036910 | MEASURING INTRAMUSCULAR FAT - Dual-energy absorptiometry is used to estimate intramuscular adipose tissue metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing intramuscular adipose tissue as well as subcutaneous adipose tissue, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the intramuscular adipose tissue in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large region and a smaller region. The regions are combined in an equation that is highly correlated with intramuscular adipose tissue measured by quantitative computed tomography in order to estimate intramuscular adipose tissue. | 02-05-2015 |
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| 20130096084 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS - The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 04-18-2013 |
| 20130137690 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the 4-carboxybenzylamino derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the 4-carboxybenzylamino derivatives in vivo. | 05-30-2013 |
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| 20090012075 | Fluorinated Arylamide Derivatives - The present invention relates to a novel class of fluorinated arylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 01-08-2009 |
| 20090062297 | Hydroxyalkylarylamide Derivatives - The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-05-2009 |
| 20090082308 | Benzothiophene derivatives - The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-26-2009 |
| 20090270351 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the phosphorus derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the phosphorus derivatives in vivo. | 10-29-2009 |
| 20100324046 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the 4-carboxybenzylamino derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the 4-carboxybenzylamino derivatives in vivo. | 12-23-2010 |
| 20110130361 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the Silicon derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the Silicon derivatives in vivo. | 06-02-2011 |
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| 20090132245 | Denoising Acoustic Signals using Constrained Non-Negative Matrix Factorization - A method and system denoises a mixed signal. A constrained non-negative matrix factorization (NMF) is applied to the mixed signal. The NMF is constrained by a denoising model, in which the denoising model includes training basis matrices of a training acoustic signal and a training noise signal and statistics of weights of the training basis matrices. The applying produces weight of a basis matrix of the acoustic signal, of the mixed signal. A product of the weights of the basis matrix of the acoustic signal and the training basis matrices of the training acoustic signal and the training noise signal is taken to reconstruct the acoustic signal. The mixed signal can be speech and noise. | 05-21-2009 |
| 20100082291 | Monitoring All-Optical Network Performance - A method monitors a performance of an all-optical network by acquiring data from the network in a form of histograms. A dimensionality of the histograms is reduced by fitting Gaussian mixture models to the histograms to produce corresponding 4-dimensional quadruples (μ | 04-01-2010 |
| 20100332186 | Probabilistic Estimation of a Time Interval Between Periodic Events Disturbing a Signal - The embodiments of the invention disclose a method for a probabalistical determination of a time interval between events, wherein the events periodically disturb a signal. The method determines, as a function of time, probabilities of occurrences of the events based on values of the signal, wherein the signal is Jittered, and determines, based on the probabilities of the occurrences of the events, probabilities of correspondence of a set of possible time intervals to the time interval between the events producing a set of probabilities of the possible time intervals suitable for determining the time interval between the events. | 12-30-2010 |
| 20110078224 | Nonlinear Dimensionality Reduction of Spectrograms - Embodiments of the invention disclose a system and a method for reducing a dimensionality of a spectrogram matrix. The method constructs an intermediate time basis matrix and an intermediate frequency basis matrix and applies iteratively a non-negative matrix factorization (NMF) to the intermediate time basis matrix and the intermediate frequency basis matrix until a termination condition is reached, wherein the NMF is subject to a constraint on a an independence regularization term, wherein the constraint is in a form of a gradient of the term. | 03-31-2011 |
| 20110137829 | Method for Selecting Neighborhoods of Training Points for Local Learning - A method selects a subset of training points near a query point from a set of training points. The subset of training points near the query point is determined from a the set of training points such that a cumulative similarity is maximized, wherein the cumulative similarity measures a similarity of the query point to each point in the subset and a similarity of points in the subset to each other. | 06-09-2011 |
| 20110160927 | Method for Prediction for Nonlinear Seasonal Time Series - A method predicts nonlinear seasonal time series data. More particularly, the method predicts short term power demand. The method uses an exponential smoothing technique and dynamic modeling of seasonal time series data with kernels. The kernels are used to predict future values of the time series from past values using nonlinear functions such as a least-squares radial basis function or support vector regression using a Gaussian kernel. | 06-30-2011 |
| 20120143799 | Method for Selecting Features Used in Continuous-Valued Regression Analysis - A method selects features used in continuous-valued regression analysis. Training data input to the method includes features and corresponding target values, wherein the target values are continuous, and there is one target value for each feature. Each threshold value is thresholded and discretized with respect to a threshold value to produce a discretized target value. Then, categorical feature selection is applied to the features, using the discrete target values, to produces selected features. The selected values can be used in any regression analysis. | 06-07-2012 |
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| 20090294991 | FLIP-CHIP INTERCONNECTION WITH FORMED COUPLINGS - A flip-chip electrical coupling between first and second electrical components ( | 12-03-2009 |
| 20100160784 | Wireless Ultrasound Probe With Audible Indicator - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds during use of the probe. The loudspeaker, which may be a piezoelectric loudspeaker, issues an alert when battery power is low or signal strength of the wireless transmission is poor or nonexistent. The loudspeaker can provide user feedback to the actuation of a button or control on the probe. The loudspeaker can provide haptic feedback during use of the probe, and can be used to produce audio Doppler tones or heart sounds during probe use. | 06-24-2010 |
| 20100160785 | Wireless Ultrasound Probe Cable - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver, a power circuit, and a rechargeable battery. The wireless probe also has a cable connector accessible from the exterior of the probe, for connection of a cable providing battery charging potential and/or imaging signal conductors for wire communication with a host system. An example is given of a magnetically attachable cable which requires no openings or indentations that could trap gel and other contaminants. Preferably the remote end of the cable uses a standardized connector, enabling the wireless probe to be recharged from standard devices like computers. | 06-24-2010 |
| 20100168576 | Light Weight Wireless Ultrasound Probe - A wireless ultrasound probe has a probe case enclosing a transducer array stack, a microbeamformer coupled to the transducer array, an acquisition module, an ultra wideband transceiver, a power circuit, and a rechargeable battery with a total weight of 300 grams or less. Preferably the total weight of these components does not exceed 150 grams, and most preferably the total weight of these components does not exceed 130 grams. The transceiver wirelessly transmits echo information signals to an ultrasound system host where the signals may undergo additional ultrasound signal processing such as further beamforming, image processing and display. The battery is preferably a rechargeable battery and the antenna for the transceiver is located at the end of the probe opposite the transducer stack. | 07-01-2010 |
| 20100168581 | WIDE BANDWIDTH MATRIX TRANSDUCER WITH POLYETHYLENE THIRD MATCHING LAYER - An ultrasound transducer comprises a piezoelectric element ( | 07-01-2010 |
| 20100277305 | Wireless Ultrasound Probe Asset Tracking - A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds as a function of the range between the wireless probe and a host system. When the probe is within a near field range of the host system, the loudspeaker is silent. But if the probe is moved to an intermediate or a far field range from the host system, the loudspeaker sounds an alert. This audible alert can be used to locate the probe by transmitting a paging signal which, upon reception by the probe, causes the probe to sound its alert. If the probe is moved to an unauthorized location where it is within range of a transmitter or receiver, the reception of a signal by the probe, the transmitter, or receiver will sound an alert signaling the unauthorized presence of the wireless probe. | 11-04-2010 |
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| 20090099077 | TREATMENT OF RETT SYNDROME AND OTHER DISORDERS - The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules. | 04-16-2009 |
| 20120177630 | TREATMENT OF RETT SYNDROME AND OTHER DISORDERS - The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules. | 07-12-2012 |
| 20130080364 | SYSTEMS AND METHODS FOR PROVIDING RECOMMENDATIONS BASED ON COLLABORATIVE AND/OR CONTENT-BASED NODAL INTERRELATIONSHIPS - In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues. Each interrelationship or link may be positive or negative and may accumulate with other links to provide nodal links the strength of which are based on commonality of attributes among the linked nodes and/or common preferences that one node, such as a reviewer, expresses for other nodes, such as venues. The links may be first order (based on a direct relationship between, for instance, a reviewer and a venue) or higher order (based on, for instance, the fact that two venue are both liked by a given reviewer). The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by aggregating the link matrices and determining the venues which are most strongly coupled to the user. | 03-28-2013 |
| 20130275511 | SYSTEMS AND METHODS FOR PROVIDING RECOMMENDATIONS BASED ON COLLABORATIVE AND/OR CONTENT-BASED NODAL INTERRELATIONSHIPS - In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues. Each interrelationship or link may be positive or negative and may accumulate with other links (or anti-links) to provide nodal links the strength of which are based on commonality of attributes among the linked nodes and/or common preferences that one node, such as a reviewer, expresses for other nodes, such as venues. The links may be first order (based on a direct relationship between, for instance, a reviewer and a venue) or higher order (based on, for instance, the fact that two venue are both liked by a given reviewer). The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by aggregating the link matrices and determining the venues which are most strongly coupled to the user. | 10-17-2013 |
| 20140129371 | SYSTEMS AND METHODS FOR PROVIDING ENHANCED NEURAL NETWORK GENESIS AND RECOMMENDATIONS - In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues which are enhanced by dynamic resonance between source sites. The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by performing geometric contextualization on generated recommendation sets and determining recommendation resonance with past recommendations. Remote businesses may also link with the recommendation generator to receive recommendations custom-tailored to their business. In selected embodiments, interconnectivity augmentation provides for enhanced neural network topology and recommendations for foreign locales. Various user interfaces are also contemplated thereby providing users with a view of the neural network topology as well as the ability to collaboratively determine meeting places. | 05-08-2014 |
| 20140244562 | SYSTEMS AND METHODS FOR PROVIDING RECOMMENDATIONS BASED ON COLLABORATIVE AND/OR CONTENT-BASED NODAL INTERRELATIONSHIPS - In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues. Each interrelationship or link may be positive or negative and may accumulate with other links (or anti-links) to provide nodal links the strength of which are based on commonality of attributes among the linked nodes and/or common preferences that one node, such as a reviewer, expresses for other nodes, such as venues. The links may be first order (based on a direct relationship between, for instance, a reviewer and a venue) or higher order (based on, for instance, the fact that two venue are both liked by a given reviewer). The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by aggregating the link matrices and determining the venues which are most strongly coupled to the user. | 08-28-2014 |
| 20140279196 | SYSTEM AND METHODS FOR PROVIDING SPATIALLY SEGMENTED RECOMMENDATIONS - In certain implementations, data is spatially segmented into a variety of grids having particular keyed location data. Items of interest located within the boundaries of each grid are identified and stored in association with the grid location information. Data with respect to venue attributes is encoded and stored in association with corresponding grid location data. The system will identify a grid location based on a recommendation request or based on the user location and will generate a list of items of interest in that location and neighboring locations. This information is filtered based on the particularities of the user request to form a final filter set. User attribute weights are then applied to the final filter set to determine an overall score for each item of interest. Items of interest are then recommended to the user based on their overall score. | 09-18-2014 |
| 20140280226 | APPARATUS AND METHOD FOR PROVIDING HARMONIZED RECOMMENDATIONS BASED ON AN INTEGRATED USER PROFILE - In certain implementations, a system may receive attribute data corresponding to attributes of a plurality of users and to one or more venues for which the plurality of users has an affinity. A user personality matrix may be calculated for one or more of the plurality of users based on interrelational nodal link strengths between the one or more users and the venues. The user personality matrices may be merged to calculate a combined personality matrix representing a unified taste profile for the one or more users. A candidate list of venues having the highest link strength with the combined personality matrix may be determined. One or more recommended venues from the candidate list of venues that have the strongest links to the combined personality matrix may be determined, and recommendation data corresponding to the recommended venues may be output. | 09-18-2014 |
| 20150066830 | SYSTEMS AND METHODS FOR PROVIDING RECOMMENDATIONS BASED ON COLLABORATIVE AND/OR CONTENT-BASED NODAL INTERRELATIONSHIPS - In selected embodiments a recommendation generator builds a network of interrelationships between venues, reviewers and users based on their attributes and reviewer and user reviews of the venues. Each interrelationship or link may be positive or negative and may accumulate with other links (or anti-links) to provide nodal links the strength of which are based on commonality of attributes among the linked nodes and/or common preferences that one node, such as a reviewer, expresses for other nodes, such as venues. The links may be first order (based on a direct relationship between, for instance, a reviewer and a venue) or higher order (based on, for instance, the fact that two venue are both liked by a given reviewer). The recommendation engine in certain embodiments determines recommended venues based on user attributes and venue preferences by aggregating the link matrices and determining the venues which are most strongly coupled to the user. | 03-05-2015 |
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| 20080317892 | MOLD FOR A GOLF BALL - A golf ball mold having a non-planar parting surface that is formed a computerized modeling system such as CAD or CAE in combination with a CNC machine tool. The mold is comprised of hemispherical upper and lower mold halves being removably mated along the non-planar parting line that is distinct from the position corresponding to an equator line of the spherical cavity. Each mold half having an interior cavity detail for creating a pattern of dimples on the cover of the golf ball, wherein at least one dimple lies across an equator of the ball and the parting line passes around and between interdigitated dimples without intersecting them, therein creating a “seamless” golf ball. The non-planar surface of the upper mold half comprising at least three true sprues for venting of air and excess material; and at least three false sprues for the placement of tabs on the cover for use in aligning the golf ball as it is spun in a buffing machine. | 12-25-2008 |
| 20090039552 | MOLDING OF GOLF BALL COVERS AND INNER LAYERS - A method of molding an inner or cover layer of a thermoset or thermoplastic material around a golf ball core within a compression mold, in which the core is positioned within a mold cavity containing preformed inner hemispherical shells and holding the opposing mold portions in a closed position wherein heat and pressure are applied. Knockout pins engage the core and layer to biasly eject it from the mold cavity, while simultaneously blowing high pressure air into the mold cavity to aid in releasing the core and layer without the need of a release agent coating the cavities. | 02-12-2009 |
| 20090088273 | GOLF BALL - A golf ball that is formed by a mold developed from a computerized modeling system such as CAD or CAE in combination with a CNC machine tool which superimposes a short waveform, or multiple waveforms, onto a longer base waveform to create a non-planar parting line that is functionally dependent on the underlying dimple geometry. The non-planar parting line is comprised of a plurality of peaks and valleys that are offset from the dimple perimeters, as not to bisect any dimple edge. Also, dimples on one side of the parting line interdigitate with dimples on the other side to form a more uniform distribution of dimples over the entire golf ball surface. Still further, the non-planar parting line has a amplitude which is less than 0.02 inch from an axis substantially coincident with the equator of the ball and the length of the parting line is less than 110 percent of the length of a curve defined by the circumference of the equator. Located at a plurality of sites on the non-planar parting line and offset from the equator are tabs which are formed on the ball to aid in the finishing operation wherein flash is removed from the ball parting line. The tabs are created by true sprues (vents) and false sprues on the parting surfaces of the ball mold halves. | 04-02-2009 |
| 20100003357 | GOLF BALL MOLD - An improved mold for making a golf ball comprises a pair of mold cups which are assembled together along mating surfaces that form a parting line. The mold cups are completely without sprues (vents). A lower mold cup has an undercut section of p to 360° in the rim area of the mating surface that allows for a very restricted but controlled flow at the parting line. The undercut section is of a depth of about 0.002 inch or less. This provides for a significant increase in the shear strength that results in a golf ball having less delamination, smaller voids, and a significant increase in impact cover durability. | 01-07-2010 |
| 20100090370 | METHOD FOR MOLDING GOLF BALL COVER OVER SOFT CORE - A method for compression molding a thin cover layer over a large or soft core golf ball, wherein the process includes mold press speed of closure, pressure within the mold cavities, temperature of materials being molded, and the movement of the compression press is controlled by as the mold position rather than any fixed amounts of time. A Ram press is moved in a very controlled fashion during the low pressure stage by a servo controller, and is governed by data fed to a control computer by a linear potentiometer, which allows for a very deliberate movement, especially over the last 0.4 inches of closing. A pressure transducer and thermocouples determine the flow point of the cover layer. Once the cover material starts to flow, the Ram press is triggered into a high pressure close wherein the cover layer is formed and then finally cooled. | 04-15-2010 |
| 20100151971 | METHOD FOR PAINTING GOLF BALLS - The present invention relates to a method for painting dimpled golf balls that are moving along an endless conveyor. The method employs paint guns operating at a relatively low atomizing air pressure, and make contact with the golf ball surface at an angle between about 5° to 60°. The paint guns are continually in the on position and the paint neither coagulates in the gun nozzle nor forms puddles in the dimple cavities. The number of golf ball painted per gallon of paint is dramatically increased as is the number of ball painted per time period. | 06-17-2010 |
| 20110187013 | METHOD FOR MOLDING GOLF BALL COVER OVER SOFT CORE - A method for compression molding a thin cover layer over a large or soft core golf ball, wherein the process includes mold press speed of closure, pressure within the mold cavities, temperature of materials being molded, and the movement of the compression press is controlled by as the mold position rather than any fixed amounts of time. A Ram press is moved in a very controlled fashion during the low pressure stage by a servo controller, and is governed by data fed to a control computer by a linear potentiometer, which allows for a very deliberate movement, especially over the last 0.4 inches of closing. A pressure transducer and thermocouples determine the flow point of the cover layer. Once the cover material starts to flow, the Ram press is triggered into a high pressure close wherein the cover layer is formed and then finally cooled. | 08-04-2011 |
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| 20080260680 | Method of Attenuating Reactions to Skin Irritants - The present invention is directed to a method of inhibiting CDld activation by administering a composition containing a moiety that blocks CDld activation. Compositions of the invention are useful for the attenuation of CDld-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration. | 10-23-2008 |
| 20100035843 | METHODS FOR ATTENUATING ALLERGEN-INDUCED AIRWAY HYPERREACTIVITY USING CD1D DEPENDENT ANTAGONISTS - The present invention is directed to a method of inhibiting allergen-induced airway CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Methods of the invention are useful for treatment and prevention of air-way hyperactivity caused by an allergen, and results in the attenuation of CD1d-restricted immune responses, including treatment of hay fever and asthma are due to air-way hyperactivity, and for systemic administration to attenuate ongoing immune responses. Preferably, these compositions are in a form intended for administration via nasal passages or directly inhaled to the air-ways. | 02-11-2010 |
| 20140286949 | METHOD OF ATTENUATING REACTIONS TO SKIN IRRITANTS - The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration. | 09-25-2014 |
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| 20090326519 | MULTIPLE LUMEN SENSOR ATTACHMENT - A cranial bolt secured to a skull of a patient includes a threaded portion and a lumen portion. Threaded portion has an inner surface forming a central passageway which extends throughout the threaded portion. The inner surface includes a connector mating with the lumen portion. The threaded portion has an outer surface having a plurality of threads for engaging a hole formed in the patient's skull. The lumen portion includes a stem portion that enters the central passageway and engages the mating connector. A fluid tight seal is formed between the inner surface of the threaded portion and the stem portion. At least two lumens are disposed through the stem portion and the base portion. The lumens have a proximal end opening outside the skull and a distal end opening inside the skull. One embodiment includes sensor lumens diverging from the centerline and another allows lumen portion to rotate independent of threaded portion. | 12-31-2009 |
| 20120078159 | MULTI-LUMEN VENTRICULAR DRAINAGE CATHETER - A shunt includes a housing having an inlet, an outlet and a flow control mechanism disposed within the housing. A ventricular catheter is connected to the inlet of the housing. The catheter has a longitudinal length, a proximal end, a distal end, and an inner lumen extending therethrough. The inner lumen of the catheter includes at least two lumens at the distal end and has only one lumen at the proximal end. The catheter has one slit and aperture corresponding to each of the at least two lumens located at the distal end of the catheter. | 03-29-2012 |
| 20140052047 | METHOD AND TOOLS FOR IMPLANTED DEVICE - A method and toolset capable of remotely moving a rotor of an implanted device in a first arcuate direction and detecting a first limit of travel, moving the rotor in a second, opposite direction and detecting a second limit of travel without altering the current performance setting of the implanted device, comparing the first and second limits of travel with known values for a plurality of selectable performance settings, and indicating the current performance setting of the implanted device. | 02-20-2014 |
