Patent application number | Description | Published |
20080211500 | Detection and Reduction of Dielectric Breakdown in Semiconductor Devices - Methods for detecting the breakdown potential of a semiconductor device having a thin dielectric layer are disclosed. The method includes measuring a spectroscopy of the thin dielectric layer and determining whether the spectroscopy exhibits the presence of a breakdown precursor (H | 09-04-2008 |
20090005243 | Doped metal organic frameworks for reversible H2 storage at ambient temperature - Metal-organic frameworks (MOFs) are provided. An exemplary MOF includes a plurality of metal clusters, at least one linking ligand, and at least one dopant. Doped MOFs according to embodiments of the present invention have significantly increased H2 uptake capacity, and some embodiments meet the 2010 DOE H2 storage target of 6 wt % at a temperature ranging from −30 to 80° C. and a pressure less than or equal to 100 bar. | 01-01-2009 |
20090020148 | METHODS AND DEVICES FOR CONTROLLING THERMAL CONDUCTIVITY AND THERMOELECTRIC POWER OF SEMICONDUCTOR NANOWIRES - Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled substantially independently of the electrical conductivity of the nanowires by controlling dimensions and doping, respectively, of the nanowires. A thermoelectric device comprising p-doped and n-doped semiconductor nanowire thermocouples is also shown, together with a method to fabricate alternately p-doped and n-doped arrays of silicon nanowires. | 01-22-2009 |
20090029221 | FUNCTIONAL ANCHORS CONNECTING GRAPHENE-LIKE CARBON TO METAL - Functional linkers or anchors interconnecting graphene-like carbon, such as nanotubes or graphite sheets, with a conducting material such as a metal, are shown, together with related structures, devices, methods and systems. | 01-29-2009 |
20090035836 | MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS - The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In that embodiment, the non-natural amino acids preferably have desirable side-chain pKa's, such that at below physiological pH (e.g. about pH 6.3-6.5) the non-natural amino acid confer enhanced binding to tumor antigens in acidic environments. Such non-natural amino acids can be incorporated by any suitable means, such as by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs (e.g. the degenerate codon orthogonal system. | 02-05-2009 |
20090037118 | METHODS FOR PREDICTING THREE-DIMENSIONAL STRUCTURES FOR ALPHA HELICAL MEMBRANE PROTEINS AND THEIR USE IN DESIGN OF SELECTIVE LIGANDS - A method for practical prediction of the three-dimensional structure of α-helical membrane proteins (HMPs) is described. The method allows one to predict the binding site and structure for strongly bound ligands. The method combines a protocol of computational methods enabling a complete ensemble of packings to be sampled and systematically reducing this ensemble to progressively more accurate structures until at the end there remain a few that might be functionally relevant and likely to play a role in all binding and activation processes. This method is well suited to automatic operation making it practical to obtain, for example, the ensemble of important structures for all human GPCRs. With this ensemble of all active GPCR structures in the human body, an infimum method is presented to maximize efficacy toward the selected target while minimizing binding to all other GPCRs to eliminate toxicity arising from cross-reacting with other GPCRs (a most common source of drug failure). This infimum method is broadly applicable to any set of proteins where a ligand is desired to be able to modulate the function of one protein while not affecting the function of other proteins. | 02-05-2009 |
20100022731 | Co-polymer films for sensors - Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed. | 01-28-2010 |
20100069621 | POLYNUCLEOTIDES AND RELATED NANOASSEMBLIES, STRUCTURES, ARRANGEMENTS, METHODS AND SYSTEMS - A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems. | 03-18-2010 |
20100299127 | SYSTEM AND METHODS FOR PREDICTING TRANSMEMBRANE DOMAINS IN MEMBRANE PROTEINS AND MINING THE GENOME FOR RECOGNIZING G-PROTEIN COUPLED RECEPTORS - The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of transmembrane regions in proteins, such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a coarse grain sampling method, such as hydrophobicity analysis, to provide a fast and accurate procedure for predicting transmembrane regions. Methods and apparatus of the invention are useful to screen protein or polynucleotide databases for encoded proteins with transmembrane regions, such as GPCRs. | 11-25-2010 |
20110060114 | Co-Polymer Films for Sensors - Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed. | 03-10-2011 |
20140323542 | TARGETING DOMAIN AND RELATED SIGNAL ACTIVATED MOLECULAR DELIVERY - Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems. | 10-30-2014 |
20140329880 | EXONUCLEASE RESISTANT POLYNUCLEOTIDE AND RELATED DUPLEX POLYNUCLEOTIDES, CONSTRUCTS, COMPOSITIONS, METHODS AND SYSTEMS - Provided herein are exonuclease resistant polynucleotides and related constructs, compositions, methods and systems. | 11-06-2014 |