Patent application number | Description | Published |
20080286881 | COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES - Compositions are disclosed. One embodiment of a composition comprises a first antibody having an affinity for an antigen and a second antibody having an affinity for the first antibody, wherein at least one antibody is conjugated to a marker, and wherein the antigen is not present in the composition. Further disclosed are methods of using compositions according to the invention for analyzing a biological sample by antibody profiling for identifying forensic samples or detecting the presence of an analyte. In embodiments of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, may be coupled to a test for identity such that the results of the assay may be positively correlated to the subject's identity. | 11-20-2008 |
20080298667 | IMAGE PORTION IDENTIFICATION METHODS, IMAGE PARSING METHODS, IMAGE PARSING SYSTEMS, AND ARTICLES OF MANUFACTURE - Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates. | 12-04-2008 |
20080300796 | BIOLOGICAL ANALYSIS METHODS, BIOLOGICAL ANALYSIS DEVICES, AND ARTICLES OF MANUFACTURE - Biological analysis methods, biological analysis devices, and articles of manufacture are described. Biological analysis methods access data regarding one or more images of a plurality of different combinations of biological receptors which individually have reacted with one or more biological indicators of a biological sample, analyze the data, and based on the analysis, create a profile comprising values representative of the biological indicators. Other biological analysis methods first access a plurality of first values individually corresponding to a plurality of biological indicators of a first subject, second access a plurality of second values individually corresponding to a plurality of biological indicators of a second subject, analyze the first and second values with respect to one another, and provide information regarding similarity of the first subject and the second subject using the analysis. | 12-04-2008 |
20090203107 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 08-13-2009 |
20090215168 | Transcriptional control in alicyclobacillus acidocaldarius and associated genes, proteins, and methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 08-27-2009 |
20090253205 | Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 10-08-2009 |
20090263859 | Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 10-22-2009 |
20090269827 | Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldadarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 10-29-2009 |
20100203583 | Alteration and modulation of protein activity by varying post-translational modification - Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins. | 08-12-2010 |
20100311110 | Thermal and acid tolerant beta xylosidases, arabinofuranosidases, genes encoding, related organisms, and methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 12-09-2010 |
20110065594 | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual - A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source. | 03-17-2011 |
20110065601 | IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL - A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source. | 03-17-2011 |
20110081683 | Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes - A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from | 04-07-2011 |
20110136175 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 06-09-2011 |
20110143395 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 06-16-2011 |
20110165625 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 07-07-2011 |
20110250683 | Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 10-13-2011 |
20110275135 | Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 11-10-2011 |
20120015407 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 01-19-2012 |
20120070894 | Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 03-22-2012 |
20120288932 | THERMOPHILIC AND THERMOACIDOPHILIC SUGAR TRANSPORTER GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 11-15-2012 |
20130029400 | GENETIC ELEMENTS, PROTEINS, AND ASSOCIATED METHODS INCLUDING APPLICATION OF ADDIITNAL GENETIC INFORMATION TO GRAM (+) THERMOACIDOPHILES - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 01-31-2013 |
20130171730 | THERMOPHILIC AND THERMOACIDOPHILIC SUGAR TRANSPORTER GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 07-04-2013 |
20130302858 | METHODS OF COMBINED BIOPROCESSING AND RELATED MICROORGANISMS, THERMOPHILIC AND/OR ACIDOPHILIC ENZYMES, AND NUCLEIC ACIDS ENCODING SAID ENZYMES - A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from | 11-14-2013 |
20130316406 | THERMOPHILIC AND THERMOACIDOPHILIC BIOPOLYMER-DEGRADING GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 11-28-2013 |
20140093936 | TYPE II RESTRICTION MODIFICATION SYSTEM METHYLATION SUBUNIT OF ALICYCLOBACILLUS ACIDOCALDARIUS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 04-03-2014 |
20140162323 | METHODS OF COMBINED BIOPROCESSING AND RELATED MICROORGANISMS, THERMOPHILIC AND/OR ACIDOPHILIC ENZYMES, AND NUCLEIC ACIDS ENCODING SAID ENZYMES - A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from | 06-12-2014 |
20140273238 | TRANSCRIPTIONAL CONTROL IN ALICYCLOBACILLUS ACIDOCALDARIUS AND ASSOCIATED GENES, PROTEINS, AND METHODS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 09-18-2014 |
20140274758 | ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL - A sample of a biological material having individual-specific antibodies is contacted with an array of less than about 200 proteins on a support to bind some of the individual-specific antibodies to the proteins of the array to form immune complexes. A detection agent with an interacting protein for conjugation to a marker is applied to the array to detect the immune complexes and obtain an antibody profile, which is compared to a known antibody profile obtained from an individual. The array may further include control spots including human IgG to form control complexes and volume assessment spots including volume determination proteins to form volume complexes. Intensity of the control complexes may be detected to determine if results of the identifying are complete. Intensity of the volume complexes may be detected to determine if a volume of the sample is sufficient for an accurate result. | 09-18-2014 |