Patent application number | Description | Published |
20090111142 | Method for manufacturing a recombinant polyclonal protein - The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the collection, which encodes a distinct member of a polyclonal protein. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a collection of vectors. The present method is suitable for manufacturing recombinant polyclonal antibodies for therapeutic uses. | 04-30-2009 |
20090136498 | Method for Manufacturing Recombinant Polyclonal Proteins - The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each call in the collection is transfected with and capable of expressing one member of the library, which encodes a distinct member of a polyclonal protein that binds a particular antigen and which is located at the same single site in the genome of individual cells in said collection, wherein said nucleic acid sequence is not naturally associated with said cell in the collection. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence id introduced into the cells by transfection with a library of vectors for site-specific integration. The present method is suitable for manufacturing recombinant polyclonal antibodies, thereby making available a superior replacement of plasma-derived therapeutic immunoglobulin products. | 05-28-2009 |
20090137003 | Methods for recombinant manufacturing of anti-RSV antibodies - The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells are cultured under suitable conditions for expression of the anti-RSV antibody/antibodies. The nucleic acid sequence is introduced into the cells by transfection with expression vectors, which avoid site-specific integration. The present method is suitable for manufacturing recombinant mono- and polyclonal anti-RSV antibodies for therapeutic uses. | 05-28-2009 |
20110117605 | Methods for Manufacturing a Polyclonal Protein - The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein. | 05-19-2011 |
20120009623 | Methods for Recombinant Manufacturing of Anti-RSV Antibodies - The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells are cultured under suitable conditions for expression of the anti-RSV antibody/antibodies. The nucleic acid sequence is introduced into the cells by transfection with expression vectors, which avoid site-specific integration. The present method is suitable for manufacturing recombinant mono- and polyclonal anti-RSV antibodies for therapeutic uses. | 01-12-2012 |
Patent application number | Description | Published |
20130214898 | SYSTEM AND METHOD FOR SECURE ENTRY USING DOOR TOKENS - Secure door entry without a traditional card reader is made possible by tagging the door with an unpowered, unique token which can be read by a user's personal mobile electronic device. The user's device transmits both door and user identification to a remote server, where the decision is made whether to open the door. If so, the server sends an open door signal using the IP suite of protocols to an electronic bridge, which in turn passes the signal on to a door strike, opening the door. Another signal may be sent to an annunciator. Single-use digital tokens may also be used to open the doors. The permissions relating to doors or other physical assets may also be used to grant access to logical assets. | 08-22-2013 |
20130214901 | SYSTEM, STATION AND METHOD FOR MUSTERING - Mustering of persons from a building in an emergency situation is made possible by tagging mustering stations with unpowered, unique tokens which can be read by a user's personal mobile electronic device. The user's device transmits both mustering station identity and user identification to a remote server, where, upon successful validation, the user is removed from a list of persons to be mustered. The system may be part of a physical access security system for the building, in which single-use digital tokens as well as traditional cards may be used to open the doors. The permissions relating to doors or other physical assets may also be used to grant access to logical assets within the building. | 08-22-2013 |
20130214902 | SYSTEMS AND METHODS FOR NETWORKS USING TOKEN BASED LOCATION - Devices are operated dependent on a user's location being confirmed as in the vicinity of an unpowered token, such as an NFC chip or QR code. The tokens may be attached to the devices which will only operate if triggered by a user scanning the corresponding token with a personal mobile device. In other cases, the scanning of a token may cause a remote server to perform an action that depends on the user being in proximity to the token. | 08-22-2013 |
20140009781 | System And Method for Secure Printing - Secure printer operation using a traditional card reader located at the printer. A print job is requested at a computer remote from the printer, the print job is stored at a server, and when a user scans an access card or fob at the reader, a signal is sent to the server, which then commands the printer to start printing. | 01-09-2014 |
20140070002 | SYSTEM AND METHOD FOR PRINTER OPERATION BASED ON USER PROXIMITY - Secure, shared operation of a group printer is made possible by tagging a printer with an unpowered, unique, identifying token which can be read by a user's personal mobile electronic device. The user's device transmits both printer and user identification to a remote server or computer, from which a command to start the printer is issued. Commands may be sent using the IP suite of protocols. The system may also support single-use digital tokens to allow users external to the group to print on an occasional basis. | 03-13-2014 |