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| 20100267037 | GENOTOXICITY AS A BIOMARKER FOR INFLAMMATION - The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood. | 10-21-2010 |
| 20130323746 | GENOTOXICITY AS A BIOMARKER FOR INFLAMMATION - The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood. | 12-05-2013 |
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| 20090178098 | SYSTEM FOR REMOTELY CONTROLLING CLIENT RECORDING AND STORAGE BEHAVIOR - A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests. | 07-09-2009 |
| 20110047579 | System for remotely controlling client recording and storage behavior - A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests. | 02-24-2011 |
| 20130084058 | SYSTEM FOR REMOTELY CONTROLLING CLIENT RECORDING AND STORAGE BEHAVIOR - A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The viewer may request that certain content be captured. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests. | 04-04-2013 |
| 20150319504 | SYSTEM FOR REMOTELY CONTROLLING CLIENT RECORDING AND STORAGE BEHAVIOR - A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The viewer may request that certain content be captured. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests. | 11-05-2015 |
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| 20120149342 | Priority Inbox Notifications and Synchronization for Mobile Messaging Application - At a client device with a display and in a method for displaying messages at the client device, the client device receives message information from a server system, the message information representing a set of messages. In accordance with a determination that the set of messages include one or more unread priority messages, where priority messages are messages that satisfy predefined message importance criteria, the device presents a new mail notification. In accordance with a determination that the set of messages do not include any unread priority messages, the device foregoes presenting a new mail notification. | 06-14-2012 |
| 20120324381 | GRAPHICAL ICON PRESENTATION - Aspects of this disclosure may be directed to one or more techniques for a mobile device to present a graphical user-interface with different graphical user-interface layouts. The mobile device may present the different graphical user-interface layouts based on whether the mobile device is resting or not resting against a surface. For example, the mobile device may present a graphical user-interface layout that is more conducive for user interface when the mobile device is not held against a surface. The mobile device may present another graphical user-interface layout that is more conducive for user interaction when the mobile device is held against a surface. | 12-20-2012 |
| 20120324384 | GRAPHICAL ICON PRESENTATION - Aspects of this disclosure may be directed to one or more techniques for a mobile device to present a graphical user-interface with different graphical user-interface layouts. The mobile device may present the different graphical user-interface layouts based on whether the mobile device is resting or not resting against a surface. For example, the mobile device may present a graphical user-interface layout that is more conducive for user interface when the mobile device is not held against a surface. The mobile device may present another graphical user-interface layout that is more conducive for user interaction when the mobile device is held against a surface. | 12-20-2012 |
| 20130041968 | PRIORITY INBOX NOTIFICATIONS AND SYNCHRONIZATION FOR MESSAGING APPLICATION - Systems and methods for priority inbox notifications and synchronization are disclosed. In some embodiments, a method includes, at a computer system, obtaining message information from a server system. The message information represents a set of messages and an importance score associated with each message in the set of messages. The importance score is generated based at least in part on a global importance prediction model and a user importance prediction model. A new mail notification is presented when a determination is made that the set of messages include one or more unread priority messages. The priority messages comprise messages with which the associated importance score satisfy one or more predefined message importance criteria: Optionally, presentation of a new mail notification is foregone when there is a determination that the set of messages do not include any unread priority messages. | 02-14-2013 |
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| 20100240982 | System for the Assessment of Sleep Quality in Adults and Children - Systems and methods for assessment of sleep quality in adults and children are provided. These techniques include an apparatus worn above the forehead containing the circuitry for collecting and storing physiological signals. The apparatus integrates with a sensor strip and a nasal mask to obtain the physiological signals for the user. The form factor of this apparatus is comfortable, easy to self-apply, and results in less data artifacts than conventional techniques for capturing physiological data for analyzing sleep quality. Neuro-respiratory signals are analyzed using means to extract more accurate definitions of the frequency and severity of sleep discontinuity, sleep disordered breathing and patterns of sleep architecture. Biological biomarkers and questionnaire responses can also be compared to a database of healthy and chronically diseased patients to provide a more accurate differential diagnosis and to help determine the appropriate disease management recommendations. | 09-23-2010 |
| 20100268096 | Method and Apparatus For Non-Invasive Assessment of Hemodynamic and Functional State of the Brain - A method and apparatus for assessment of hemodynamic and functional state of the brain is disclosed. In one embodiment, the method and apparatus includes non-invasive measurement of intracranial pressure, assessment of the brain's electrical activity, and measurement of cerebral blood flow. In some embodiments, the method and apparatus include measuring the volume change in the intracranial vessels with a near-infrared spectroscopy or other optical method, measuring the volume change in the intracranial vessels with rheoencephalography or other electrical method, and measuring the brain's electrical activity using electroencephalography. | 10-21-2010 |
| 20100292545 | INTERACTIVE PSYCHOPHYSIOLOGICAL PROFILER METHOD AND SYSTEM - An efficient, objective, flexible and easily deployable system for conducting evaluations of mental and physiological state and recommending individualized treatment to improve said state is described. The method and system are based on commensurate measurement of mental functions, levels of stress and anxiety, and/or biologically active molecules such as neurotransmitters, immune markers including cytokines and hormones. The method and system are designed to assess an individual's cognitive function and the underlying physiology in order to delineate various disease processes, injuries, drug states, training stages, fatigue levels, stress levels, aging processes, predict susceptibility to stress and/or sleep deprivation, identify aptitude for training and/or characterize effects of any experimental conditions. The system and method may be used in recommending individualized treatment protocols, as well as to guide the treatment process by assessing the efficacy of such therapies in the clinical trials process. | 11-18-2010 |
| 20110132378 | Systems and Methods For Controlling Position - Systems and methods for controlling the position of a user of a wearable positional therapy device are provided. The wearable position therapy device can be configured to monitor and store physiological signals that can be used to assess sleep quality and sleeping position of a user. The device can be configured to be worn around the head, the neck, or body of the user. The device can be configured to provide feedback to a user if the user is sleeping or is positioned in a target position to induce the user to change positions. The feedback can be provided by one or more haptic motors that can be configured to provide various levels of feedback and the level of feedback can be customized based on the user's reaction to the feedback. | 06-09-2011 |
| 20130131464 | SYSTEM FOR THE ASSESSMENT OF SLEEP QUALITY IN ADULTS AND CHILDREN - Systems and methods for assessment of sleep quality in adults and children are provided. These techniques include an apparatus worn above the forehead containing the circuitry for collecting and storing physiological signals. The apparatus integrates with a sensor strip and a nasal mask to obtain the physiological signals for the user. The form factor of this apparatus is comfortable, easy to self-apply, and results in less data artifacts than conventional techniques for capturing physiological data for analyzing sleep quality. Neuro-respiratory signals are analyzed using means to extract more accurate definitions of the frequency and severity of sleep discontinuity, sleep disordered breathing and patterns of sleep architecture. Biological biomarkers and questionnaire responses can also be compared to a database of healthy and chronically diseased patients to provide a more accurate differential diagnosis and to help determine the appropriate disease management recommendations. | 05-23-2013 |
| 20140309483 | SYSTEMS AND METHODS FOR CONTROLLING POSITION - Systems and methods for assessing compliance with position therapy. In an embodiment, position therapy is provided to a user while the user is wearing a position therapy device. The position therapy comprises, by the device, collecting positional data, determining positions of the user over a time period based on the positional data, and, when it is determined that the user is in a target position, providing feedback to the user to influence the user to change to a non-target position. In addition, the device stores a duration of use in its memory. The duration of use indicates a duration that the user has used the wearable position therapy device in each of one or more positions. An assessment of the user's compliance with the position therapy is then provided based, at least in part, on the duration of use. | 10-16-2014 |
| 20140309502 | SYSTEMS AND METHODS FOR CONTROLLING POSITION - A wearable positional therapy device for influencing a position of a user. In an embodiment, the device comprises a position detector that generates positional data used to determine a position of a user, a feedback generator that generates feedback to the user, and a microcontroller. The microcontroller is configured to receive and analyze the positional data to determine whether the user is in a target position, while, in response to the device being turned on or a reset operation, delaying feedback for a delay period. If it is determined that the user is in the target position during the delay period, no feedback is provided. However, if it is determined that the user is in the target position following the delay period, feedback is provided to the user to induce the user to change to a different, non-target position. | 10-16-2014 |
